                         б

<110>  Ϻѱ¹＼޹˾
 
<120>  ͨǶϿԭTϸӦ

<130>  P11079-PCT

<160>  82    

<170>  PatentIn version 3.3

<210>  1
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA12-21nt   DNA

<400>  1
tctacatcat cactgaatac a                                               21


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA12-20nt   DNA

<400>  2
ctacatcatc actgaataca                                                 20


<210>  3
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA12-19nt   DNA

<400>  3
tacatcatca ctgaataca                                                  19


<210>  4
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA12-18nt  DNA

<400>  4
acatcatcac tgaataca                                                   18


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA16-21nt   DNA

<400>  5
catcactgaa tacatggaga a                                               21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA16-20nt   DNA

<400>  6
atcactgaat acatggagaa                                                 20


<210>  7
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA16-19nt   DNA

<400>  7
tcactgaata catggagaa                                                  19


<210>  8
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA16-18nt   DNA

<400>  8
cactgaatac atggagaa                                                   18


<210>  9
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  LCK-T316Iͻ䵰

<400>  9

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Ile Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  10
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>   LCK-T316Aͻ䵰

<400>  10

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Ala Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  11
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  LCK-T316Mͻ䵰

<400>  11

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Met Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-saCas9-sgRNA1	DNA

<400>  12
ctacatcatc actgaataca tg                                              22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-saCas9-sgRNA2	DNA

<400>  13
atcactgaat acatggagaa tg                                              22


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA1    DNA

<400>  14
gctacccgag tcggctacca                                                 20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA11    DNA

<400>  15
gctctacgct gtggtcaccc                                                 20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA8    DNA

<400>  16
gtattcagtg atgatgtaga                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA9    DNA

<400>  17
tattcagtga tgatgtagat                                                 20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  LCK-sgRNA12    DNA

<400>  18
ctacatcatc actgaataca                                                 20


<210>  19
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316I-for-sgRNA8   Ϊ޸ģDNA

<400>  19
acgccttcct ggccgaggcc aacctcatga agcagctgca acaccagcgg ctggttcggc     60

tctacgctgt ggtcacccag gagcccatct acatcatcat tgaatacatg gagaatggtg    120

ggtgctaccc gagtc                                                     135


<210>  20
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316I-for-sgRNA9  Ϊ޸ģDNA

<400>  20
gacgccttcc tggccgaggc caacctcatg aagcagctgc aacaccagcg gctggttcgg     60

ctctacgctg tggtcaccca ggagcccatc tacatcatca ttgaatacat ggagaatggt    120

gggtgctacc cgagt                                                     135


<210>  21
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316I-for-sgRNA12  Ϊ޸ģDNA

<400>  21
aaaaggtgta tttccaccct ctggcaggga cagcagggag agcagtatcc cctggtagcc     60

gactcgggta gcacccacca ttctccatgt attcaatgat gatgtagatg ggctcctggg    120

tgaccacagc gtaga                                                     135


<210>  22
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>   ssDNA-T316M-for-sgRNA8  Ϊ޸ģDNA

<400>  22
acgccttcct ggccgaggcc aacctcatga agcagctgca acaccagcgg ctggttcggc     60

tctacgctgt ggtcacccag gagcccatct acatcatcat ggaatacatg gagaatggtg    120

ggtgctaccc gagtc                                                     135


<210>  23
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>   ssDNA-T316M-for-sgRNA9  Ϊ޸ģDNA

<400>  23
gacgccttcc tggccgaggc caacctcatg aagcagctgc aacaccagcg gctggttcgg     60

ctctacgctg tggtcaccca ggagcccatc tacatcatca tggaatacat ggagaatggt    120

gggtgctacc cgagt                                                     135


<210>  24
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316M-for-sgRNA12  Ϊ޸ģDNA

<400>  24
aaaaggtgta tttccaccct ctggcaggga cagcagggag agcagtatcc cctggtagcc     60

gactcgggta gcacccacca ttctccatgt attccatgat gatgtagatg ggctcctggg    120

tgaccacagc gtaga                                                     135


<210>  25
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316A-for-sgRNA8  Ϊ޸ģDNA

<400>  25
acgccttcct ggccgaggcc aacctcatga agcagctgca acaccagcgg ctggttcggc     60

tctacgctgt ggtcacccag gagcccatct acatcatcgc cgaatacatg gagaatggtg    120

ggtgctaccc gagtc                                                     135


<210>  26
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316A-for-sgRNA9  Ϊ޸ģDNA

<400>  26
gacgccttcc tggccgaggc caacctcatg aagcagctgc aacaccagcg gctggttcgg     60

ctctacgctg tggtcaccca ggagcccatc tacatcatcg ccgaatacat ggagaatggt    120

gggtgctacc cgagt                                                     135


<210>  27
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316A-for-sgRNA12  Ϊ޸ģDNA

<400>  27
aaaaggtgta tttccaccct ctggcaggga cagcagggag agcagtatcc cctggtagcc     60

gactcgggta gcacccacca ttctccatgt attccgggat gatgtagatg ggctcctggg    120

tgaccacagc gtaga                                                     135


<210>  28
<211>  265
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316I-for-sgRNA1+sgRNA11  Ϊ޸ģDNA

<400>  28
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattca atgatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaaggcgt    240

ccggggacat gctgccctgc ttcag                                          265


<210>  29
<211>  265
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316M-for-sgRNA1+sgRNA11  Ϊ޸ģDNA

<400>  29
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattcc atgatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaaggcgt    240

ccggggacat gctgccctgc ttcag                                          265


<210>  30
<211>  265
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316A-for-sgRNA1+sgRNA11  Ϊ޸ģDNA

<400>  30
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattcc gggatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaaggcgt    240

ccggggacat gctgccctgc ttcag                                          265


<210>  31
<211>  235
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316I-for-sgRNA1+sgRNA12  Ϊ޸ģDNA

<400>  31
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattca atgatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaa         235


<210>  32
<211>  235
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316M-for-sgRNA1+sgRNA12  Ϊ޸ģDNA

<400>  32
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattcc atgatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaa         235


<210>  33
<211>  235
<212>  DNA
<213>  Artificial

<220>
<223>  ssDNA-T316A-for-sgRNA1+sgRNA12  Ϊ޸ģDNA

<400>  33
aggaaagctc aagaaaccct ccttgcttga gctttgggcc agaagaaaag gtgtatttcc     60

accctctggc agggacagca gggagagcag tatcccctgg tagccgactc gggtagcacc    120

caccattctc catgtattcc gggatgatgt agatgggctc ctgggtgacc acagcgtaga    180

gccgaaccag ccgctggtgt tgcagctgct tcatgaggtt ggcctcggcc aggaa         235


<210>  34
<211>  1690
<212>  PRT
<213>  Escherichia coli

<400>  34

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  His His His 
    1670                 1675                 1680             


His His  His His His His His  
    1685                 1690 


<210>  35
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-78 VL

<400>  35
caggctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc     60

tcctgttctg gaagcagctc caacatcgga aataatgctg taagctggta ccagcagctc    120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctcccctc aggggtctct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg    300

ttcggcggag ggaccaaggt caccgtccta ggt                                 333


<210>  36
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-78 VL

<400>  36

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110     


<210>  37
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-78 VH

<400>  37
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac    240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gcgcctgtct    300

tactcttggt cttcttggta ctgggatttc tggggtcaag gtactctggt gaccgtctcc    360

tca                                                                  363


<210>  38
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-78 VH

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  39
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-Linker1 

<400>  39
ggtggtggtg gtagcggcgg cggcggctct ggtggtggtg gatcc                     45


<210>  40
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-Linker1 

<400>  40

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  41
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CD8a hinge

<400>  41
actactaccc ctgcacctag gcctcccacc ccagccccaa caatcgccag ccagcctctg     60

tctctgcggc ccgaagcctg tagacctgct gccggcggag ccgtgcacac cagaggcctg    120

gacttcgcct gcgac                                                     135


<210>  42
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>   CD19-CD8a hinge

<400>  42

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  43
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CD8a TM

<400>  43
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgag cctggtgatc     60

accctgtact gc                                                         72


<210>  44
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-CD8a TM

<400>  44

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  45
<211>  123
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CD28ڽṹ(IC)

<400>  45
agaagcaagc ggagccggct gctgcacagc gactacatga acatgacccc aagacggcct     60

ggccccaccc ggaagcacta ccagccttac gcccctccca gagacttcgc cgcctaccgg    120

tcc                                                                  123


<210>  46
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-CD28ڽṹ(IC)

<400>  46

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  47
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CD3zźŽṹ

<400>  47
agagtgaagt tcagcagatc cgccgacgcc cctgcctacc agcagggaca gaaccagctg     60

tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa gcggagaggc    120

cgggaccccg agatgggcgg aaagcccaga cggaagaacc cccaggaagg cctgtataac    180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg    240

aggcgcggca agggccacga tggcctgtac cagggcctga gcaccgccac caaggacacc    300

tacgacgccc tgcacatgca ggccctgccc cccaga                              336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-CD3zźŽṹ򵰰

<400>  48

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  49
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-T2A

<400>  49
gagggaaggg gcagcttatt aacatgtggc gatgtggaag agaaccccgg tccc           54


<210>  50
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-T2A

<400>  50

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  51
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CSF2RA signal

<400>  51
atgctgctgc tcgtgacctc tttactgtta tgtgagctgc cccaccccgc ttttttactg     60

atccct                                                                66


<210>  52
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-CSF2RA signal

<400>  52

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  53
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-tEGFR

<400>  53
cgtaaggtgt gtaacggaat cggcattggc gagttcaagg actctttaag catcaacgcc     60

acaaacatca agcacttcaa gaattgtacc tccatcagcg gcgatttaca cattctcccc    120

gtggcttttc gtggcgattc cttcacccac accccccctc tggaccccca agagctggac    180

attttaaaaa ccgtgaagga gatcaccggc tttctgctga tccaagcttg gcccgagaat    240

cgtaccgacc tccacgcctt cgagaattta gagattattc gtggaaggac caagcagcac    300

ggccagttct ctttagccgt cgtgtcttta aacattacca gcctcggttt aaggtcttta    360

aaggagatta gcgacggcga cgtgatcatc tccggcaaca agaacctctg ctacgccaac    420

accatcaact ggaagaagct gttcggaacc agcggccaaa agaccaagat catcagcaat    480

cgtggagaga actcttgtaa ggccactggt caagtttgcc acgccctctg tagccccgaa    540

ggatgttggg gccccgagcc tagggactgt gttagctgca gaaacgtgag cagaggcaga    600

gagtgtgtgg acaaatgcaa tttactggaa ggagagccta gggagttcgt ggagaacagc    660

gaatgtatcc agtgccaccc cgagtgttta cctcaagcca tgaacatcac ttgtaccgga    720

aggggccccg ataactgcat ccaatgcgcc cactacatcg acggacccca ctgcgtgaaa    780

acttgtcccg ccggagtgat gggagagaat aacactttag tgtggaagta cgccgacgct    840

ggccacgtct gccatctgtg ccaccccaac tgtacctacg gctgcactgg tcccggttta    900

gagggatgtc ctaccaacgg ccccaagatc ccctccatcg ccaccggaat ggtgggcgct    960

ctgttattac tgctggtggt ggctctgggc atcggtttat tcatg                   1005


<210>  54
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-tEGFR

<400>  54

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  55
<211>  2649
<212>  DNA
<213>  Artificial

<220>
<223>  CD19-CD28z-CAR

<400>  55
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

ccccaggctg tgctgactca gccaccctcg gtgtctgaag cccccaggca gagggtcacc    120

atctcctgtt ctggaagcag ctccaacatc ggaaataatg ctgtaagctg gtaccagcag    180

ctcccaggaa aggctcccaa actcctcatc tattatgatg atctgctccc ctcaggggtc    240

tctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc    300

cagtctgagg atgaggctga ttattactgt gcagcatggg atgacagcct gaatggttgg    360

gtgttcggcg gagggaccaa ggtcaccgtc ctaggtggtg gtggtggtag cggcggcggc    420

ggctctggtg gtggtggatc cgaggtgcag ctggtgcagt ctggagcaga ggtgaaaaag    480

cccggggagt ctctgaagat ctcctgtaag ggttctggat acagctttac cagctactgg    540

atcggctggg tgcgccagat gcccgggaaa ggcctggagt ggatggggat catctatcct    600

ggtgactctg ataccagata cagcccgtcc ttccaaggcc aggtcaccat ctcagccgac    660

aagtccatca gcaccgccta cctgcagtgg agcagcctga aggcctcgga caccgccatg    720

tattactgtg cgcgcctgtc ttactcttgg tcttcttggt actgggattt ctggggtcaa    780

ggtactctgg tgaccgtctc ctcattcgtg cccgtgttcc tgcccgccaa acctactact    840

acccctgcac ctaggcctcc caccccagcc ccaacaatcg ccagccagcc tctgtctctg    900

cggcccgaag cctgtagacc tgctgccggc ggagccgtgc acaccagagg cctggacttc    960

gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct gctgctgagc   1020

ctggtgatca ccctgtactg caaccaccgg aacagaagca agcggagccg gctgctgcac   1080

agcgactaca tgaacatgac cccaagacgg cctggcccca cccggaagca ctaccagcct   1140

tacgcccctc ccagagactt cgccgcctac cggtccagag tgaagttcag cagatccgcc   1200

gacgcccctg cctaccagca gggacagaac cagctgtaca acgagctgaa cctgggcaga   1260

cgggaagagt acgacgtgct ggacaagcgg agaggccggg accccgagat gggcggaaag   1320

cccagacgga agaaccccca ggaaggcctg tataacgaac tgcagaaaga caagatggcc   1380

gaggcctaca gcgagatcgg catgaagggc gagcggaggc gcggcaaggg ccacgatggc   1440

ctgtaccagg gcctgagcac cgccaccaag gacacctacg acgccctgca catgcaggcc   1500

ctgcccccca gaggatccgg agagggaagg ggcagcttat taacatgtgg cgatgtggaa   1560

gagaaccccg gtcccatgct gctgctcgtg acctctttac tgttatgtga gctgccccac   1620

cccgcttttt tactgatccc tcgtaaggtg tgtaacggaa tcggcattgg cgagttcaag   1680

gactctttaa gcatcaacgc cacaaacatc aagcacttca agaattgtac ctccatcagc   1740

ggcgatttac acattctccc cgtggctttt cgtggcgatt ccttcaccca caccccccct   1800

ctggaccccc aagagctgga cattttaaaa accgtgaagg agatcaccgg ctttctgctg   1860

atccaagctt ggcccgagaa tcgtaccgac ctccacgcct tcgagaattt agagattatt   1920

cgtggaagga ccaagcagca cggccagttc tctttagccg tcgtgtcttt aaacattacc   1980

agcctcggtt taaggtcttt aaaggagatt agcgacggcg acgtgatcat ctccggcaac   2040

aagaacctct gctacgccaa caccatcaac tggaagaagc tgttcggaac cagcggccaa   2100

aagaccaaga tcatcagcaa tcgtggagag aactcttgta aggccactgg tcaagtttgc   2160

cacgccctct gtagccccga aggatgttgg ggccccgagc ctagggactg tgttagctgc   2220

agaaacgtga gcagaggcag agagtgtgtg gacaaatgca atttactgga aggagagcct   2280

agggagttcg tggagaacag cgaatgtatc cagtgccacc ccgagtgttt acctcaagcc   2340

atgaacatca cttgtaccgg aaggggcccc gataactgca tccaatgcgc ccactacatc   2400

gacggacccc actgcgtgaa aacttgtccc gccggagtga tgggagagaa taacacttta   2460

gtgtggaagt acgccgacgc tggccacgtc tgccatctgt gccaccccaa ctgtacctac   2520

ggctgcactg gtcccggttt agagggatgt cctaccaacg gccccaagat cccctccatc   2580

gccaccggaa tggtgggcgc tctgttatta ctgctggtgg tggctctggg catcggttta   2640

ttcatgtga                                                           2649


<210>  56
<211>  882
<212>  PRT
<213>  Artificial

<220>
<223>  CD19-CD28z-CAR

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Asn Asn Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
            100                 105                 110         


Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
                165                 170                 175     


Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
        195                 200                 205             


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Leu Ser Tyr Ser Trp Ser Ser Trp Tyr Trp Asp 
                245                 250                 255     


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val 
            260                 265                 270         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        275                 280                 285             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    290                 295                 300                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
305                 310                 315                 320 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                325                 330                 335     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser 
            500                 505                 510         


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu 
        515                 520                 525             


Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
    530                 535                 540                 


Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys 
545                 550                 555                 560 


Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys 
                565                 570                 575     


Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly 
            580                 585                 590         


Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile 
        595                 600                 605             


Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp 
    610                 615                 620                 


Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile 
625                 630                 635                 640 


Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser 
                645                 650                 655     


Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp 
            660                 665                 670         


Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr 
        675                 680                 685             


Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile 
    690                 695                 700                 


Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys 
705                 710                 715                 720 


His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp 
                725                 730                 735     


Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
            740                 745                 750         


Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
        755                 760                 765             


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr 
    770                 775                 780                 


Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile 
785                 790                 795                 800 


Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu 
                805                 810                 815     


Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
            820                 825                 830         


Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu 
        835                 840                 845             


Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met 
    850                 855                 860                 


Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu 
865                 870                 875                 880 


Phe Met 
        


<210>  57
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-Ab20001-61-VH

<400>  57
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc aactatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcct acaatggtga cacaaaatat    180

gcacagaggc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac    240

atggagctga ggaacctaag atctgacgac acggccgtgt attactgtgc gcgctacgaa    300

tctatgtctg gtcaggatat ctggggtcaa ggtactctgg tgaccgtctc ctca          354


<210>  58
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-Ab20001-61-VH

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Lys Tyr Ala Gln Arg Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Glu Ser Met Ser Gly Gln Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  59
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-Ab20001-42-VH

<400>  59
gaagttcagc tgctggaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg     60

agctgtgcag caagcggttt tacctttagc catagcgcca tgggttgggt tcgtcaggca    120

cctggtaaag gtctggaatg ggttagcagc atctatgccc gcggcggcta tacctattat    180

gcagatagcg ttaaaggtcg ttttaccatt agccgtgata acagcaaaaa taccctgtac    240

ctgcagatga atagtctgcg tgcagaggat accgcagtgt attattgtgc gcgcggttac    300

catctggaat acatggtttc tcaggatgtt tggggtcaag gtactctggt gaccgtctcc    360

tca                                                                  363


<210>  60
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-Ab20001-42-VH

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Ser 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ala Arg Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr His Leu Glu Tyr Met Val Ser Gln Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  61
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-Linker1 

<400>  61
ggtggtggtg gtagcggcgg cggcggctct ggtggtggtg gatcc                     45


<210>  62
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-Linker1 

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  381
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-CD8a

<400>  63
tttgtgcctg tatttctgcc tgccaagccc accacaacac ctgcccctag accacccacc     60

cctgccccca ccattgcttc tcagcccctt agcttaagac ctgaagcctg tagacctgct    120

gctggggggg ctgtgcacac aagaggcctg gactttgcct gtactactac ccctgcacct    180

aggcctccca ccccagcccc aacaatcgcc agccagcctc tgtctctgcg gcccgaagcc    240

tgtagacctg ctgccggcgg agccgtgcac accagaggcc tggacttcgc ctgcgacatc    300

tacatctggg cccccctggc tggcacctgt ggggtgctgc tgctgagcct ggtgatcacc    360

ctgtactgca accacagaaa c                                              381


<210>  64
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-CD8a

<400>  64

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    50                  55                  60                  


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
65                  70                  75                  80  


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                85                  90                  95      


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            100                 105                 110         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
        115                 120                 125         


<210>  65
<211>  123
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-CD28ڽṹ(IC)

<400>  65
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  66
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-CD28ڽṹ(IC)

<400>  66

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  67
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-CD3zźŽṹ

<400>  67
agagtgaagt tcagcagatc tgctgatgcc cctgcctatc agcaagggca gaatcagctg     60

tacaatgagc tgaatctggg cagaagagag gagtatgatg tgctggacaa gagaagaggc    120

agagaccctg agatgggggg caagcctaga agaaagaacc cccaagaggg cctgtataat    180

gagctgcaga aggacaagat ggctgaggcc tactctgaga ttggcatgaa gggggagaga    240

agaagaggca agggccatga tggcctgtac caaggcctga gcacagccac caaggacacc    300

tatgatgccc tacacatgca agctctgcct cctaga                              336


<210>  68
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-CD3zźŽṹ򵰰

<400>  68

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  69
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-T2A

<400>  69
gaaggaaggg gcagcctact gacctgtggg gatgtggagg agaaccctgg cccc           54


<210>  70
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-T2A

<400>  70

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  71
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-CSF2RA signal

<400>  71
atgttgctat tagtaaccag cctgctgctg tgtgagctgc cccaccctgc cttcctgtta     60

atccca                                                                66


<210>  72
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-CSF2RA signal

<400>  72

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  73
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-tEGFR

<400>  73
cgaaaggtat gtaatggcat tggcattggg gagtttaagg acagcctgag catcaatgcc     60

accaacatca agcacttcaa gaactgcaca agcatcagtg gggacttgca catcctgcct    120

gtggccttca gaggggacag cttcacccac accccccccc tggaccccca agagctggac    180

atcctgaaga cagtgaagga gatcactggc ttcttgctga tccaagcctg gcctgagaac    240

agaacagacc tgcatgcctt tgagaacctg gagatcatca gaggcagaac caagcagcat    300

gggcagttca gcctggctgt ggtgagcctg aacatcacaa gcctgggcct gagaagctta    360

aaggagatct ctgatgggga tgtgatcatc tctggcaaca agaacctgtg ctatgccaac    420

accatcaact ggaagaagct gtttggcacc tctgggcaga agaccaagat catcagcaac    480

agaggggaga actcctgtaa ggccactggc caagtgtgtc atgccctatg cagccctgag    540

gggtgctggg gccctgagcc tagagactgt gtgagctgca gaaatgtgag cagaggcaga    600

gagtgtgtgg acaagtgcaa cctgctggag ggggagccta gagagtttgt ggagaactct    660

gagtgtattc agtgtcatcc tgagtgcctg ccccaagcca tgaacatcac ctgcactggc    720

agaggccctg acaactgcat tcagtgtgcc cactacattg atggccccca ctgtgtgaag    780

acctgccctg ctggggtgat gggggagaac aacaccctgg tgtggaagta tgctgatgct    840

ggccatgtgt gtcacctgtg ccatcccaac tgcacctatg gctgcactgg ccctggcctg    900

gagggctgcc ccaccaatgg tcccaagatt cctagcattg ccactggcat ggtgggggcc    960

ctgctcctac ttctggtggt tgccctgggc attggcctgt tcatg                   1005


<210>  74
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-tEGFR

<400>  74

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  75
<211>  2670
<212>  DNA
<213>  Artificial

<220>
<223>  CD5-VHH-CD28z-CAR

<400>  75
atggccctac ctgtgacagc cctactgtta cccctggccc tccttctgca tgctgctaga     60

cctcaggtgc agctggtgca gtctggggct gaggtgaaga agcctgggtc ctcggtgaag    120

gtctcctgca aggcttctgg aggcaccttc agcaactatg ctatcagctg ggtgcgacag    180

gcccctggac aagggcttga gtggatggga tggatcagcg cctacaatgg tgacacaaaa    240

tatgcacaga ggctccaggg cagagtcacc atgaccacag acacatccac gagcacagcc    300

tacatggagc tgaggaacct aagatctgac gacacggccg tgtattactg tgcgcgctac    360

gaatctatgt ctggtcagga tatctggggt caaggtactc tggtgaccgt ctcctcaggg    420

ggggggggct ctgggggggg tggctcaggt ggcggtggct ctgaagttca gctgctggaa    480

agcggtggtg gtctggttca gcctggtggt agcctgcgtc tgagctgtgc agcaagcggt    540

tttaccttta gccatagcgc catgggttgg gttcgtcagg cacctggtaa aggtctggaa    600

tgggttagca gcatctatgc ccgcggcggc tatacctatt atgcagatag cgttaaaggt    660

cgttttacca ttagccgtga taacagcaaa aataccctgt acctgcagat gaatagtctg    720

cgtgcagagg ataccgcagt gtattattgt gcgcgcggtt accatctgga atacatggtt    780

tctcaggatg tttggggtca aggtactctg gtgaccgtct cctcatttgt gcctgtattt    840

ctgcctgcca agcccaccac aacacctgcc cctagaccac ccacccctgc ccccaccatt    900

gcttctcagc cccttagctt aagacctgaa gcctgtagac ctgctgctgg gggggctgtg    960

cacacaagag gcctggactt tgcctgtgac atctacatct gggcccccct ggctggcacc   1020

tgtggggtgc tgctgctgag cctggtgatc accctgtact gcaaccacag aaacaggagt   1080

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc   1140

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga   1200

gtgaagttca gcagatctgc tgatgcccct gcctatcagc aagggcagaa tcagctgtac   1260

aatgagctga atctgggcag aagagaggag tatgatgtgc tggacaagag aagaggcaga   1320

gaccctgaga tggggggcaa gcctagaaga aagaaccccc aagagggcct gtataatgag   1380

ctgcagaagg acaagatggc tgaggcctac tctgagattg gcatgaaggg ggagagaaga   1440

agaggcaagg gccatgatgg cctgtaccaa ggcctgagca cagccaccaa ggacacctat   1500

gatgccctac acatgcaagc tctgcctcct agaggctctg gggaaggaag gggcagccta   1560

ctgacctgtg gggatgtgga ggagaaccct ggccccatgt tgctattagt aaccagcctg   1620

ctgctgtgtg agctgcccca ccctgccttc ctgttaatcc cacgaaaggt atgtaatggc   1680

attggcattg gggagtttaa ggacagcctg agcatcaatg ccaccaacat caagcacttc   1740

aagaactgca caagcatcag tggggacttg cacatcctgc ctgtggcctt cagaggggac   1800

agcttcaccc acaccccccc cctggacccc caagagctgg acatcctgaa gacagtgaag   1860

gagatcactg gcttcttgct gatccaagcc tggcctgaga acagaacaga cctgcatgcc   1920

tttgagaacc tggagatcat cagaggcaga accaagcagc atgggcagtt cagcctggct   1980

gtggtgagcc tgaacatcac aagcctgggc ctgagaagct taaaggagat ctctgatggg   2040

gatgtgatca tctctggcaa caagaacctg tgctatgcca acaccatcaa ctggaagaag   2100

ctgtttggca cctctgggca gaagaccaag atcatcagca acagagggga gaactcctgt   2160

aaggccactg gccaagtgtg tcatgcccta tgcagccctg aggggtgctg gggccctgag   2220

cctagagact gtgtgagctg cagaaatgtg agcagaggca gagagtgtgt ggacaagtgc   2280

aacctgctgg agggggagcc tagagagttt gtggagaact ctgagtgtat tcagtgtcat   2340

cctgagtgcc tgccccaagc catgaacatc acctgcactg gcagaggccc tgacaactgc   2400

attcagtgtg cccactacat tgatggcccc cactgtgtga agacctgccc tgctggggtg   2460

atgggggaga acaacaccct ggtgtggaag tatgctgatg ctggccatgt gtgtcacctg   2520

tgccatccca actgcaccta tggctgcact ggccctggcc tggagggctg ccccaccaat   2580

ggtcccaaga ttcctagcat tgccactggc atggtggggg ccctgctcct acttctggtg   2640

gttgccctgg gcattggcct gttcatgtga                                    2670


<210>  76
<211>  889
<212>  PRT
<213>  Artificial

<220>
<223>  CD5-VHH-CD28z-CAR

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly 
        35                  40                  45              


Thr Phe Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Lys 
65                  70                  75                  80  


Tyr Ala Gln Arg Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                85                  90                  95      


Thr Ser Thr Ala Tyr Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Tyr Glu Ser Met Ser Gly Gln Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser His Ser Ala Met Gly Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Ala Arg 
        195                 200                 205             


Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr His Leu 
                245                 250                 255     


Glu Tyr Met Val Ser Gln Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
            500                 505                 510         


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
        515                 520                 525             


Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
    530                 535                 540                 


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
545                 550                 555                 560 


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
                565                 570                 575     


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
            580                 585                 590         


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
        595                 600                 605             


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
    610                 615                 620                 


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
625                 630                 635                 640 


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
                645                 650                 655     


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
            660                 665                 670         


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
        675                 680                 685             


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
    690                 695                 700                 


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
705                 710                 715                 720 


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
                725                 730                 735     


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
            740                 745                 750         


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
        755                 760                 765             


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
785                 790                 795                 800 


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
                805                 810                 815     


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
            820                 825                 830         


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
        835                 840                 845             


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile 
    850                 855                 860                 


Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val 
865                 870                 875                 880 


Val Ala Leu Gly Ile Gly Leu Phe Met 
                885                 


<210>  77
<211>  1464
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA-CAR

<400>  77
tacccatacg atgttccaga ttacgctgac atccagatga cccagtctcc atcctccctg     60

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagag cattagcagc    120

tatttaaatt ggtatcagca gaaaccaggg aaagccccta agctcctgat ctatgctgca    180

tccagtttgc aaagtggggt cccatcaagg ttcagtggca gtggatctgg gacagatttc    240

actctcacca tcagcagtct gcaacctgaa gattttgcaa cttactactg tcagcaaaaa    300

tacgacctcc tcacttttgg cggagggacc aaggttgaga tcaaaggcag caccagcggc    360

tccggcaagc ctggctctgg cgagggcagc acaaagggac agctgcagct gcaggagtcg    420

ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcactgt ctctggtggc    480

tccatcagca gtagtagtta ctactggggc tggatccgcc agcccccagg gaaggggctg    540

gagtggattg ggagtatctc ctatagtggg agcacctact acaacccgtc cctcaagagt    600

cgagtcacca tatccgtaga cacgtccaag aaccagttct ccctgaagct gagttctgtg    660

accgccgcag acacggcggt gtactactgc gccagagatc gtggagacac catactagac    720

gtatggggtc agggtacaat ggtcaccgtc agctcattcg tgcccgtgtt cctgcccgcc    780

aaacctacca ccacccctgc ccctagacct cccaccccag ccccaacaat cgccagccag    840

cctctgtctc tgcggcccga agcctgtaga cctgctgccg gcggagccgt gcacaccaga    900

ggcctggact tcgcctgcga catctacatc tgggcccctc tggccggcac ctgtggcgtg    960

ctgctgctga gcctggtgat caccctgtac tgcaaccacc ggaacagaag caagcggagc   1020

cggctgctgc acagcgacta catgaacatg accccaagac ggcctggccc cacccggaag   1080

cactaccagc cttacgcccc tcccagagac ttcgccgcct accggtccag agtgaagttc   1140

agcagatccg ccgacgcccc tgcctaccag cagggacaga accagctgta caacgagctg   1200

aacctgggca gacgggaaga gtacgacgtg ctggacaagc ggagaggccg ggaccccgag   1260

atgggcggaa agcccagacg gaagaacccc caggaaggcc tgtataacga actgcagaaa   1320

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcgcggcaag   1380

ggccacgatg gcctgtacca gggcctgagc accgccacca aggacaccta cgacgccctg   1440

cacatgcagg ccctgccccc caga                                          1464


<210>  78
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA-CAR

<400>  78

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Ile Gln Met Thr Gln Ser 
1               5                   10                  15      


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
            20                  25                  30          


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
    50                  55                  60                  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Gln Gln Lys Tyr Asp Leu Leu Thr Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
        115                 120                 125             


Gly Ser Thr Lys Gly Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu 
    130                 135                 140                 


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr 
            180                 185                 190         


Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Asp Thr Ile Leu Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Phe Val Pro Val 
                245                 250                 255     


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  79
<211>  177
<212>  PRT
<213>  Artificial

<220>
<223>  hIL7İ

<400>  79

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  80
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  CCL19İ

<400>  80

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  81
<211>  206
<212>  PRT
<213>  Artificial

<220>
<223>  IL2RB-CD3zİ

<400>  81

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val 
                85                  90                  95      


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            100                 105                 110         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        115                 120                 125             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    130                 135                 140                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
145                 150                 155                 160 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                165                 170                 175     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            180                 185                 190         


Asp Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
        195                 200                 205     


<210>  82
<211>  462
<212>  PRT
<213>  Artificial

<220>
<223>  IL7RaMutİ

<400>  82

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Cys Pro Thr Ile Ser Ile Leu Ser Phe Phe Ser Val 
                245                 250                 255     


Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys 
            260                 265                 270         


Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His 
        275                 280                 285             


Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu 
    290                 295                 300                 


Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg 
305                 310                 315                 320 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
                325                 330                 335     


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
            340                 345                 350         


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
        355                 360                 365             


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
    370                 375                 380                 


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
385                 390                 395                 400 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
                405                 410                 415     


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
            420                 425                 430         


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
        435                 440                 445             


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 460         


