                         SEQUENCE LISTING

<110>  ARTHRITIS RECHERCHE & DEVELOPPEMENT
       UNIVERSITE DE TOULOUSE III
       INSERM
       CENTRE HOSPITALER UNIVERSITAIRE DE TOULOUSE
       CENTRE HOSPITALER UNIVERSITAIRE DE MONTPELLIER
       UNIVERSITE DE MONTPELLIER
 
<120>  Cellule immunitaire comprenant un rcepteur Fc  sa surface, et 
       sur lequel est greff une molcule hybride comprenant un fragment 
       Fc d'anticorps et au moins un peptide citrullin driv de la 
       fibrine, et ses utilisations

<130>  B2020832FRWO

<150>  FR2102805
<151>  2021-03-19

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (1)..(1)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (15)..(15)
<223>  X = rsidu citrullyl ou arginyl

<400>  1

Xaa Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Xaa Ala Xaa 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (3)..(3)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (7)..(7)
<223>  X = rsidu citrullyl ou arginyl

<400>  2

Gly Pro Xaa Val Val Glu Xaa His Gln Ser Ala Cys Lys Asp Ser 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (10)..(10)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (12)..(12)
<223>  X = rsidu citrullyl ou arginyl

<400>  3

Ser Gly Ile Gly Thr Leu Asp Gly Phe Xaa His Xaa His Pro Asp 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (8)..(8)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (11)..(11)
<223>  X = rsidu citrullyl ou arginyl

<400>  4

Val Asp Ile Asp Ile Lys Ile Xaa Ser Cys Xaa Gly Ser Cys Ser 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (3)..(3)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (7)..(7)
<223>  X = rsidu citrullyl

<400>  5

Gly Pro Xaa Val Val Glu Xaa His Gln Ser Ala Cys Lys Asp Ser 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (8)..(8)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (11)..(11)
<223>  X = rsidu citrullyl

<400>  6

Val Asp Ile Asp Ile Lys Ile Xaa Ser Cys Xaa Gly Ser Cys Ser 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  x
<222>  (4)..(4)
<223>  X = rsidu citrullyl

<220>
<221>  x
<222>  (8)..(8)
<223>  X = rsidu citrullyl

<400>  7

Ser Cys Ser Xaa Ala Leu Ala Xaa Glu Val Asp Leu Lys Asp Tyr 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl

<400>  8

Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln Met Xaa Met Glu 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (5)..(5)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl

<400>  9

Met Glu Leu Glu Xaa Pro Gly Gly Asn Glu Ile Thr Xaa Gly Gly 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (2)..(2)
<223>  X = rsidu citrullyl

<400>  10

Glu Xaa Gly Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (9)..(9)
<223>  X = rsidu citrullyl

<400>  11

Asp Ser Pro Gly Ser Gly Asn Ala Xaa Pro Asn Asn Pro Asp Trp 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (1)..(1)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (7)..(7)
<223>  X = rsidu citrullyl ou arginyl

<220>
<221>  X
<222>  (10)..(10)
<223>  X = rsidu citrullyl ou arginyl

<400>  12

Xaa Gly His Ala Lys Ser Xaa Pro Val Xaa Gly Ile His Thr Ser 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (15)..(15)
<223>  X = rsidu citrullyl

<400>  13

Gly Thr Phe Glu Glu Val Ser Gly Asn Val Ser Pro Gly Thr Xaa 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (10)..(10)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (12)..(12)
<223>  X = rsidu citrullyl

<400>  14

Ser Gly Ile Gly Thr Leu Asp Gly Phe Xaa His Xaa His Pro Asp 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (2)..(2)
<223>  X = rsidu citrullyl

<400>  15

Ser Xaa Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl

<400>  16

Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Xaa Gly Lys 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (4)..(4)
<223>  X = rsidu citrullyl

<400>  17

Ser Tyr Asn Xaa Gly Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (1)..(1)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (7)..(7)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (10)..(10)
<223>  X = rsidu citrullyl

<400>  18

Xaa Gly His Ala Lys Ser Xaa Pro Val Xaa Gly Ile His Thr Ser 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (1)..(1)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (15)..(15)
<223>  X = rsidu citrullyl

<400>  19

Xaa Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Xaa Ala Xaa 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X = rsidu citrullyl
<222>  (15)..(15)
<223>  X = rsidu citrullyl

<400>  20

Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Xaa 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (5)..(5)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (14)..(14)
<223>  X = rsidu citrullyl

<400>  21

Val Ile Gln Asn Xaa Gln Asp Gly Ser Val Asp Phe Gly Xaa Lys 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (2)..(2)
<223>  X = rsidu citrullyl

<400>  22

Pro Xaa Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp Trp Tyr 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide citrullin


<220>
<221>  X
<222>  (4)..(4)
<223>  X = rsidu citrullyl

<220>
<221>  X
<222>  (13)..(13)
<223>  X = rsidu citrullyl

<400>  23

Trp Tyr Asn Xaa Cys His Ala Ala Asn Pro Asn Gly Xaa Tyr Tyr 
1               5                   10                  15  


<210>  24
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  25
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment Fc + Qtag

<400>  25

Leu Leu Gln Gly Ala Arg Ser Asp Ala Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    130                 135                 140                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 


<210>  26
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fragment Fc + Qtag

<400>  26

Ala His Gly His Gly His Gly Leu Leu Gln Gly Ala Arg Ser Asp Ala 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys 
    


<210>  27
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys Asp Ser Asp 
1               5                   10                  15      


Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys Pro Ser Gly 
            20                  25                  30          


Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp Phe Thr Asn 
        35                  40                  45              


Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln Lys Asn Asn 
    50                  55                  60                  


Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile Leu Arg Gly 
65                  70                  75                  80  


Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn Arg Val Ser 
                85                  90                  95      


Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys Val Ile Glu 
            100                 105                 110         


Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg Ala Gln Leu 
        115                 120                 125             


Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys Ile Arg Ser 
    130                 135                 140                 


Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys 
145                 150                 155                 160 


Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile Ala Lys Asp 
                165                 170                 175     


Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile Lys Met Lys 
            180                 185                 190         


Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln Leu Gln Lys 
        195                 200                 205             


Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln Met Arg Met 
    210                 215                 220                 


Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly Gly Ser Thr 
225                 230                 235                 240 


Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn Pro Ser Ser 
                245                 250                 255     


Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser Thr Gly Asn 
            260                 265                 270         


Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr Trp Lys Pro 
        275                 280                 285             


Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser Gly Ser Ser 
    290                 295                 300                 


Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro Arg Pro Gly 
305                 310                 315                 320 


Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly Ser Ala Gly 
                325                 330                 335     


His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly Gln Trp His 
            340                 345                 350         


Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser Gly Asn Ala 
        355                 360                 365             


Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val Ser Gly Asn 
    370                 375                 380                 


Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu Val Thr 
385                 390                 395                 400 


Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys Val Thr Ser 
                405                 410                 415     


Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr Val Thr Lys 
            420                 425                 430         


Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys Glu Val Val 
        435                 440                 445             


Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp Leu Gly Thr 
    450                 455                 460                 


Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp 
465                 470                 475                 480 


Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr Phe Pro Gly 
                485                 490                 495     


Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr Glu Ser Arg 
            500                 505                 510         


Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser Ser Ser His 
        515                 520                 525             


His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser Ser Ser Tyr 
    530                 535                 540                 


Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr 
545                 550                 555                 560 


Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly Ser Glu Ala 
                565                 570                 575     


Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala Lys Ser Arg 
            580                 585                 590         


Pro Val Arg Gly Ile His Thr Ser 
        595                 600 


<210>  28
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg 
1               5                   10                  15      


Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala 
            20                  25                  30          


Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala 
        35                  40                  45              


Gly Gly Cys Leu His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr 
    50                  55                  60                  


Gly Cys Gln Leu Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg 
65                  70                  75                  80  


Asn Ser Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr 
                85                  90                  95      


Ser Ser Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln 
            100                 105                 110         


Lys Arg Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr 
        115                 120                 125             


Ser Ser Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn 
    130                 135                 140                 


Ser Asn Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn 
145                 150                 155                 160 


Leu Arg Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met 
                165                 170                 175     


Glu Tyr Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val 
            180                 185                 190         


Ser Gly Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser 
        195                 200                 205             


Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val 
    210                 215                 220                 


Tyr Cys Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn 
225                 230                 235                 240 


Arg Gln Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys 
                245                 250                 255     


Gln Gly Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys 
            260                 265                 270         


Gly Leu Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu 
        275                 280                 285             


Thr Arg Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys 
    290                 295                 300                 


Gly Asp Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu 
305                 310                 315                 320 


Ala Asn Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly 
                325                 330                 335     


Asn Ala Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr 
            340                 345                 350         


Met Thr Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn 
        355                 360                 365             


Asp Gly Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp 
    370                 375                 380                 


Gly Gly Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly 
385                 390                 395                 400 


Arg Tyr Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly 
                405                 410                 415     


Thr Asp Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser 
            420                 425                 430         


Met Arg Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
        435                 440                 445         


<210>  29
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Qtag

<400>  29

Leu Leu Gln Gly 
1               


<210>  30
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser 
625                 630                 635 


<210>  31
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


