                         SEQUENCE LISTING

<110>  Shattuck Labs Inc.
 
<120>  GAMMA DELTA T-CELL COSTIMULATION

<130>  SHK-042PC/116981-5042

<150>  US 63/161,512
<151>  2021-03-16

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (5)..(8)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (13)..(16)
<223>  Xaa is a  positively charged amino acid such as arginine, 
       histidine or lysine, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa 
            20  


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (5)..(8)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (13)..(16)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  3
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa a spacer amino acid such as serine or glycine

<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine.

<220>
<221>  MISC_FEATURE
<222>  (7)..(10)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is a spacer amino acid such as serine or glycine.

<220>
<221>  MISC_FEATURE
<222>  (12)..(15)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine.

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine , and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is a spacer amino acid such as serine or glycine.

<220>
<221>  MISC_FEATURE
<222>  (22)..(25)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  3

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is a spacer amino acid such as serine or glycine.

<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid.

<220>
<221>  MISC_FEATURE
<222>  (7)..(10)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is a spacer amino acid such as serine or glycine.

<220>
<221>  MISC_FEATURE
<222>  (12)..(15)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid.

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is a spacer amino acid such as serine or glycine.

<220>
<221>  MISC_FEATURE
<222>  (22)..(25)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  4

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (5)..(8)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (10)..(13)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (14)..(17)
<223>  Xaa is a positively charged amino acid such as arginine, 
       histidine or lysine, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (18)..(21)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (5)..(8)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (10)..(13)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (14)..(17)
<223>  Xaa is a negatively charged amino acid such as aspartic acid or 
       glutamic acid, and any of them can be absent.

<220>
<221>  MISC_FEATURE
<222>  (18)..(21)
<223>  Xaa is a spacer amino acid such as serine or glycine, and any of 
       them can be absent.

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa 
            20      


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Gly Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Gly Ser Gly Ser Arg Lys Cys Gly Lys Arg Gly Ser 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10

Gly Ser Gly Ser Asp Glu Cys Gly Glu Asp Gly Ser 
1               5                   10          


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Arg Lys Gly Gly Lys Arg 
1               5       


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Gly Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser 
1               5                   10          


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Asp Glu Gly Gly Glu Asp 
1               5       


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
1               5                   10          


<210>  15
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  15

Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys Ile Glu Gly Arg Met Asp 
225                 230                 


<210>  16
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_charge polarized core domain

<400>  16

Gly Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro 
1               5                   10                  15      


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    50                  55                  60                  


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp 
225                 230                 235                 240 


Glu Gly Gly Glu Asp Gly Ser Gly Ser 
                245                 


<210>  17
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_charge polarized core domain

<400>  17

Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser Lys Tyr Gly Pro 
1               5                   10                  15      


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    50                  55                  60                  


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg 
225                 230                 235                 240 


Lys Gly Gly Lys Arg Gly Ser Gly Ser 
                245                 


<210>  18
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  18

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  19
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  19

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  20
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  20

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  21
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  21

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Ile 
225         


<210>  22
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_core domain

<400>  22

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  23
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_Fc domain

<400>  23

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp 
225                 230                 235             


<210>  24
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_Fc domain

<400>  24

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp 
225                 230                 235             


<210>  25
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_Fc domain

<400>  25

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp 
225                 230                 235             


<210>  26
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_Fc domain

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp 
225                 230                 235             


<210>  27
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly 
1               5                   10                  15      


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
            20                  25                  30          


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
        35                  40                  45              


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
    50                  55                  60                  


Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val 
65                  70                  75                  80  


Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg 
                85                  90                  95      


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu 
            100                 105                 110         


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His 
        115                 120                 125             


Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro 
    130                 135                 140                 


Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala 
145                 150                 155                 160 


Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr 
                165                 170                 175     


Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser 
            180                 185                 190         


Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile 
        195                 200                 205             


Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala 
    210                 215                 220 


<210>  28
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly 
1               5                   10                  15      


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
            20                  25                  30          


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
        35                  40                  45              


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
    50                  55                  60                  


Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val 
65                  70                  75                  80  


Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg 
                85                  90                  95      


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu 
            100                 105                 110         


Val 
    


<210>  29
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly 
1               5                   10                  15      


Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu 
            20                  25                  30          


Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn 
        35                  40                  45              


Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr 
    50                  55                  60                  


Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala 
65                  70                  75                  80  


Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu 
                85                  90                  95      


Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu 
            100                 105                 110         


Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr 
        115                 120                 125             


Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro 
    130                 135                 140                 


Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr 
145                 150                 155                 160 


Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala 
                165                 170                 175     


Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr 
            180                 185                 190         


Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile 
        195                 200                 205             


Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala 
    210                 215                 220                 


Gly 
225 


<210>  30
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val 
1               5                   10                  15      


Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala 
            20                  25                  30          


Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val 
        35                  40                  45              


Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys 
65                  70                  75                  80  


Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr 
                85                  90                  95      


Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu 
            100                 105                 110         


Leu Lys Val Ala 
        115     


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Arg Phe Met Ile Ser Glu Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Pro Ala Gly Thr Thr Asp Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asp 
                85                  90                  95      


Ser Tyr Gly Tyr Arg Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 


<210>  33
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Lys Val 
    210                 215                 220                 


Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  34
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr 
            20                  25                  30          


Tyr Met His Phe Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ile Tyr Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr 
    130                 135                 140                 


Ser Leu Gly Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile 
145                 150                 155                 160 


Tyr Ser Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln 
                165                 170                 175     


Leu Leu Ile Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser 
        195                 200                 205             


Met Gln Thr Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr 
    210                 215                 220                 


Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235             


<210>  35
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
    130                 135                 140                 


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
145                 150                 155                 160 


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
                165                 170                 175     


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
            180                 185                 190         


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
        195                 200                 205             


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    210                 215                 220                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
225                 230                 235                 


<210>  36
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr 
65                  70                  75                  80  


Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
    130                 135                 140                 


Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu 
                165                 170                 175     


Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu 
            180                 185                 190         


Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
225                 230                 235             


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37

Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Gly Gln Thr Val Val Thr 
1               5                   10                  15      


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
            20                  25                  30          


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
        35                  40                  45              


Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
    50                  55                  60                  


Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
65                  70                  75                  80  


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                85                  90                  95      


Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
            100                 105                 110         


Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120 


<210>  38
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  38

Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu 
1               5                   10                  15      


Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe 
            20                  25                  30          


Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu 
    50                  55                  60                  


Glu Lys Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
65                  70                  75                  80  


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
                85                  90                  95      


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
            100                 105                 110         


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
        115                 120                 125             


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
    130                 135                 140                 


Ala Val Tyr Tyr Cys Val Ser Gly Met Lys Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser 
                165     


<210>  39
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asp Thr Ile Arg Gly Pro Asn Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Thr 
    130                 135                 140                 


Thr Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Thr Trp Leu Ala 
                165                 170                 175     


Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Met Tyr Ala 
            180                 185                 190         


Ala Ser Asn Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ser Ile Phe Pro Pro Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Asp Ile Lys 
                245                 


<210>  40
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Arg Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Ser Asp Tyr Asp Tyr Tyr Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu 
                165                 170                 175     


Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
            180                 185                 190         


Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Phe Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  41
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Gly Asp Leu Ala Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Pro Asp Gly Gly Gln Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Phe Asn Ala Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Tyr Val Gly Gly Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
145                 150                 155                 160 


Gly Ile Ser Gln Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Ser Asp Ala Ser Asn Leu Glu Pro Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
        195                 200                 205             


Thr Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Asp Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  42
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Phe 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Asp Gly Ser Asn Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Ala Gly Asp Gly Gly Tyr Asp Val Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu 
            180                 185                 190         


Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Thr Phe Gly 
225                 230                 235                 240 


Pro Gly Thr Lys Val Asp Ile Lys 
                245             


<210>  43
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Thr Asp Tyr Tyr Gly Ser Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Gly Ile Gly Ile Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Arg Ser Gly Lys Pro Pro Gln Leu Leu Ile His Gly Ala Ser Thr Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Ser Tyr 
    210                 215                 220                 


Trp Cys Gln Gln Ser Asn Asn Phe Pro Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  44
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Pro Ser Ser Trp Gly Glu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Arg Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Asp Ile Lys 
                


<210>  45
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Leu Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Val Lys 
                


<210>  46
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asn His Tyr Gly Ser Gly Ser Tyr Tyr Tyr Tyr Gln Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Ala Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
145                 150                 155                 160 


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
                165                 170                 175     


Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Ile 
225                 230                 235                 240 


Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255 


<210>  47
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Arg Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Leu Thr Gly Asp Thr Ser Tyr Asn Gln Lys Ser 
    50                  55                  60                  


Lys Leu Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Val Gly Gly Asp Trp Gln Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Pro Tyr Ile His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Thr Ser 
            180                 185                 190         


Ala Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Trp Leu Ser His Pro Pro Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  48
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Leu Ile Tyr Ala Thr Ser 
            180                 185                 190         


Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  49
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Asp Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
    130                 135                 140                 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145                 150                 155                 160 


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 


<210>  50
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  50

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
        115                 120                 125             


Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Arg Ser His Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ser Ser Ile Ser Ser Asp Ser Thr Tyr Thr Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Gly Gln Trp Lys Tyr Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250 


<210>  51
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  51

Gln Ser Val Val Thr Gln Pro Pro Ser Met Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Gln Val Thr Ile Ser Cys Ser Gly Gly Asn Ser Asn Ile Glu Arg Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Leu Gln Leu Pro Gly Thr Ala Pro Lys Leu Val 
        35                  40                  45              


Ile Phe Asp Asn Asp Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Leu Glu Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asn Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Thr Ile Asn Gly Arg Gly Ser Ser Thr Ile Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Ala Arg Tyr Ile Ser Arg Gly Leu Gly Asp Ser Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val 
                245             


<210>  52
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  53
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  53

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
        115                 120                 125             


Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val 
145                 150                 155                 160 


Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 
                165                 170                 175     


Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe Lys Gly Arg Phe Ala 
            180                 185                 190         


Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser 
        195                 200                 205             


Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Gly Gly Phe 
    210                 215                 220                 


Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  54
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  54

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His 
    130                 135                 140                 


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  55
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  55

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Arg Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Lys 
                165                 170                 175     


Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe 
            180                 185                 190         


Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu 
        195                 200                 205             


Lys Lys Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Gly Gly Tyr Gly 
    210                 215                 220                 


Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  56
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Leu Tyr Phe Gly Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Gly Thr Ser Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg His Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Leu Tyr Arg Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  57
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  57

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Leu Tyr Arg Ser 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ser Ala Ser Gly Phe Asp Phe Thr Thr Tyr Trp Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile His Pro Asp 
                165                 170                 175     


Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Ser Leu Tyr Phe Gly 
    210                 215                 220                 


Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  58
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  58

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Ile Thr Tyr Phe Pro Ser Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Phe Gly Ser Ser Gly Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Glu Asn Ile Phe Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ser Pro Lys Leu Leu Val Tyr Asn Thr Lys Thr Leu Ala Glu Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 
    210                 215                 220                 


His His Tyr Gly Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  59
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Gln Leu Gln Glu Ser 
        115                 120                 125             


Gly Pro Gly Leu Val Lys Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Val Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
145                 150                 155                 160 


Thr Pro Glu Arg Arg Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly 
                165                 170                 175     


Gly Ile Thr Tyr Phe Pro Ser Thr Val Lys Gly Arg Phe Thr Val Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala His Tyr Phe Gly Ser 
    210                 215                 220                 


Ser Gly Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ala 
    


<210>  60
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu 
145                 150                 155                 160 


Arg Arg Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser 
            180                 185                 190         


Asp Lys Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys 
        195                 200                 205             


Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser 
225                 230                 235                 240 


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  61
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  61

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val 
145                 150                 155                 160 


Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu 
            180                 185                 190         


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250         


<210>  62
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Trp Tyr Asn Gly Arg Lys Gln Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Thr Gly Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  63
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ala Ile Trp Tyr Asn 
                165                 170                 175     


Gly Arg Lys Gln Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Gly Thr Gly Tyr 
    210                 215                 220                 


Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  64
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Ser Leu Val Tyr Cys Gly Gly Asp Cys Tyr Ser Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Ser Phe Thr Cys 
145                 150                 155                 160 


Gln Ala Ser Gln Asp Ile Asn Asn Phe Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Gly Asn Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Arg 
                245 


<210>  65
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  65

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Phe Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asn Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
        115                 120                 125             


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr 
    130                 135                 140                 


Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile 
145                 150                 155                 160 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr 
                165                 170                 175     


Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
            180                 185                 190         


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
        195                 200                 205             


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Ser Leu Val Tyr Cys 
    210                 215                 220                 


Gly Gly Asp Cys Tyr Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  66
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Asn Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
145                 150                 155                 160 


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Asn Asp Ala Ser Tyr Leu Glu Thr Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Glu Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  67
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  67

Ala Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Asp Ala Ser Tyr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Asn 
                165                 170                 175     


Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met 
            180                 185                 190         


Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Ser Tyr 
    210                 215                 220                 


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  68
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  68

Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Val Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Thr Ala Pro Lys Trp Tyr Arg Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  69
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  69

Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Trp Tyr 
        35                  40                  45              


Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala Trp Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Lys Ser 
                165                 170                 175     


Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
    210                 215                 220                 


Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp Ser Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  70
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Val Ser 
    130                 135                 140                 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Ser Asn Ile 
145                 150                 155                 160 


Gly Ser Glu Ser Val Asn Trp Tyr Gln Trp Lys Ser Gly Gln Val Pro 
                165                 170                 175     


Val Leu Val Val Ser Asp Thr Thr Asp Pro Arg Ser Gly Ile Pro Gly 
            180                 185                 190         


Arg Phe Thr Gly Thr Arg Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser 
        195                 200                 205             


Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr His Cys Gln Val Trp Asp 
    210                 215                 220                 


Asp Thr Gly Asp His Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  71
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Ser Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Trp Lys Ser Gly Gln Val Pro Val Leu Val Val Ser 
        35                  40                  45              


Asp Thr Thr Asp Pro Arg Ser Gly Ile Pro Gly Arg Phe Thr Gly Thr 
    50                  55                  60                  


Arg Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr His Cys Gln Val Trp Asp Asp Thr Gly Asp His 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                165                 170                 175     


Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Arg 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Asn 
    210                 215                 220                 


Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  72

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  73
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Asp Glu Gly Gly Glu Asp Gly Ser Gln Val Gln Leu Gln 
                485                 490                 495     


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser 
            500                 505                 510         


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn Trp Val 
        515                 520                 525             


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Trp Pro 
    530                 535                 540                 


Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr 
545                 550                 555                 560 


Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                565                 570                 575     


Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Glu Thr 
            580                 585                 590         


Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        595                 600                 605             


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser 
625                 630                 635                 640 


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser 
                645                 650                 655     


Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln 
            660                 665                 670         


Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
        675                 680                 685             


Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Phe Thr Leu Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr 
705                 710                 715                 720 


His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Glu Ile Lys 
            740     


<210>  74
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Asp Glu Gly Gly Glu Asp Gly Ser Asp Ile Gln Met Thr 
                485                 490                 495     


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
            500                 505                 510         


Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln 
        515                 520                 525             


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg 
    530                 535                 540                 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
545                 550                 555                 560 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
                565                 570                 575     


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly 
            580                 585                 590         


Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    610                 615                 620                 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
625                 630                 635                 640 


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
                645                 650                 655     


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
            660                 665                 670         


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
        675                 680                 685             


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
    690                 695                 700                 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
705                 710                 715                 720 


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                725                 730 


<210>  75
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Glu 
465                 470                 475                 480 


Gly Gly Glu Asp Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
                485                 490                 495     


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
            500                 505                 510         


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
        515                 520                 525             


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
    530                 535                 540                 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
545                 550                 555                 560 


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
                565                 570                 575     


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            580                 585                 590         


Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys 
        595                 600                 605             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    610                 615                 620                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
625                 630                 635                 640 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                645                 650                 655     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            660                 665                 670         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        675                 680                 685             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    690                 695                 700                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
705                 710                 715                 720 


Val Thr Val Ser Ser 
                725 


<210>  76
<211>  2178
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Thr Gly Gly Ala Gly Thr Thr Cys Gly Gly Cys Cys Thr Gly Ala 
1               5                   10                  15      


Gly Cys Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Cys Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Cys Cys Ala Gly Thr Thr Cys Ala 
    50                  55                  60                  


Thr Cys Gly Thr Gly Gly Thr Gly Gly Gly Cys Cys Cys Thr Ala Cys 
65                  70                  75                  80  


Cys Gly Ala Cys Cys Cys Ala Ala Thr Cys Cys Thr Gly Gly Cys Cys 
                85                  90                  95      


Ala Cys Ala Gly Thr Gly Gly Gly Cys Gly Ala Gly Ala Ala Cys Ala 
            100                 105                 110         


Cys Cys Ala Cys Ala Cys Thr Gly Ala Gly Gly Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Cys Thr Gly Thr Cys Cys Cys Cys Ala Gly Ala Gly Ala Ala Gly 
    130                 135                 140                 


Ala Ala Thr Gly Cys Cys Gly Ala Gly Gly Ala Thr Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Gly Thr Gly Cys Gly Gly Thr Gly Gly Thr Thr Cys Ala Gly 
                165                 170                 175     


Ala Thr Cys Thr Cys Ala Gly Thr Thr Thr Ala Gly Cys Cys Cys Cys 
            180                 185                 190         


Gly Cys Cys Gly Thr Gly Thr Thr Cys Gly Thr Gly Thr Ala Thr Ala 
        195                 200                 205             


Ala Gly Gly Gly Cys Gly Gly Cys Cys Gly Gly Gly Ala Gly Ala Gly 
    210                 215                 220                 


Ala Ala Cys Cys Gly Ala Gly Gly Ala Gly Cys Ala Gly Ala Thr Gly 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Gly Thr Ala Cys Ala Gly Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Cys Ala Cys Cys Ala Cys Ala Thr Thr Thr Gly Thr Gly Ala Gly 
            260                 265                 270         


Cys Ala Ala Gly Gly Ala Cys Ala Thr Cys Thr Cys Cys Cys Gly Cys 
        275                 280                 285             


Gly Gly Cys Thr Cys Thr Gly Thr Gly Gly Cys Cys Cys Thr Gly Gly 
    290                 295                 300                 


Thr Cys Ala Thr Cys Cys Ala Cys Ala Ala Cys Ala Thr Cys Ala Cys 
305                 310                 315                 320 


Cys Gly Cys Cys Cys Ala Gly Gly Ala Gly Ala Ala Thr Gly Gly Cys 
                325                 330                 335     


Ala Cys Ala Thr Ala Thr Cys Gly Gly Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Thr Cys Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Ala Thr Cys 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Thr Gly Ala Gly Gly Cys Cys Ala Thr Cys 
    370                 375                 380                 


Cys Thr Gly Cys Ala Cys Cys Thr Gly Gly Thr Gly Gly Thr Gly Gly 
385                 390                 395                 400 


Cys Ala Gly Gly Cys Cys Thr Gly Gly Gly Ala Thr Cys Thr Ala Ala 
                405                 410                 415     


Gly Cys Cys Cys Cys Thr Gly Ala Thr Cys Ala Gly Cys Ala Thr Gly 
            420                 425                 430         


Ala Gly Gly Gly Gly Ala Cys Ala Cys Gly Ala Gly Gly Ala Cys Gly 
        435                 440                 445             


Gly Ala Gly Gly Ala Ala Thr Cys Ala Gly Gly Cys Thr Gly Gly Ala 
    450                 455                 460                 


Gly Thr Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Cys Ala Ala Gly Cys Cys Thr Cys 
                485                 490                 495     


Thr Gly Ala Cys Cys Gly Thr Gly Thr Gly Gly Ala Gly Ala Gly Ala 
            500                 505                 510         


Thr Cys Cys Cys Thr Ala Cys Gly Gly Ala Gly Gly Ala Gly Thr Gly 
        515                 520                 525             


Gly Cys Ala Cys Cys Thr Gly Cys Cys Cys Thr Gly Ala Ala Gly Gly 
    530                 535                 540                 


Ala Gly Gly Thr Gly Thr Cys Cys Ala Thr Gly Cys Cys Ala Gly Ala 
545                 550                 555                 560 


Cys Gly Cys Cys Gly Ala Thr Gly Gly Cys Cys Thr Gly Thr Thr Cys 
                565                 570                 575     


Ala Thr Gly Gly Thr Gly Ala Cys Cys Ala Cys Ala Gly Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Cys Cys Gly Gly Gly Ala Cys Ala Ala 
        595                 600                 605             


Gly Thr Cys Thr Gly Thr Gly Ala Gly Ala Ala Ala Thr Ala Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Gly Cys Ala Gly Cys Ala Thr Cys Ala Ala Cys Ala 
625                 630                 635                 640 


Ala Thr Ala Cys Ala Cys Thr Gly Cys Thr Gly Gly Gly Cys Cys Ala 
                645                 650                 655     


Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Ala Gly Cys Gly Thr Gly 
            660                 665                 670         


Ala Thr Cys Thr Thr Cys Ala Thr Cys Cys Cys Cys Gly Ala Gly Thr 
        675                 680                 685             


Cys Cys Thr Thr Thr Ala Thr Gly Cys Cys Ala Thr Cys Cys Gly Thr 
    690                 695                 700                 


Gly Thr Cys Thr Cys Cys Ala Thr Gly Thr Gly Cys Ala Gly Gly Ala 
705                 710                 715                 720 


Ala Gly Cys Gly Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Gly Gly 
                725                 730                 735     


Gly Ala Gly Gly Cys Ala Ala Gly Ala Gly Gly Gly Gly Ala Ala Gly 
            740                 745                 750         


Cys Ala Ala Gly Thr Ala Thr Gly Gly Ala Cys Cys Ala Cys Cys Thr 
        755                 760                 765             


Thr Gly Cys Cys Cys Ala Cys Cys Ala Thr Gly Thr Cys Cys Ala Gly 
    770                 775                 780                 


Cys Ala Cys Cys Ala Gly Ala Gly Thr Thr Thr Cys Thr Gly Gly Gly 
785                 790                 795                 800 


Ala Gly Gly Ala Cys Cys Ala Thr Cys Cys Gly Thr Gly Thr Thr Cys 
                805                 810                 815     


Cys Thr Gly Thr Thr Thr Cys Cys Thr Cys Cys Ala Ala Ala Gly Cys 
            820                 825                 830         


Cys Cys Ala Ala Gly Gly Ala Cys Cys Ala Gly Cys Thr Gly Ala Thr 
        835                 840                 845             


Gly Ala Thr Cys Thr Cys Cys Ala Gly Gly Ala Cys Cys Cys Cys Ala 
    850                 855                 860                 


Gly Ala Gly Gly Thr Gly Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly 
865                 870                 875                 880 


Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Thr Cys Thr Cys Ala 
                885                 890                 895     


Gly Gly Ala Gly Gly Ala Thr Cys Cys Thr Gly Ala Gly Gly Thr Gly 
            900                 905                 910         


Cys Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly 
        915                 920                 925             


Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr 
    930                 935                 940                 


Gly Cys Ala Cys Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Cys 
945                 950                 955                 960 


Ala Ala Gly Cys Cys Cys Ala Gly Gly Gly Ala Gly Gly Ala Gly Cys 
                965                 970                 975     


Ala Gly Thr Thr Thr Ala Ala Cys Thr Cys Cys Ala Cys Cys Thr Ala 
            980                 985                 990         


Thr Cys Gly Cys Gly Thr Gly Gly  Thr Gly Thr Cys Thr  Gly Thr Gly 
        995                 1000                 1005             


Cys Thr  Gly Ala Cys Ala Gly  Thr Gly Cys Thr Gly  Cys Ala Cys 
    1010                 1015                 1020             


Cys Ala  Gly Gly Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Gly Cys 
    1025                 1030                 1035             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1040                 1045                 1050             


Thr Gly  Cys Ala Ala Gly Gly  Thr Gly Ala Gly Cys  Thr Cys Cys 
    1055                 1060                 1065             


Ala Ala  Gly Gly Gly Cys Cys  Thr Gly Cys Cys Thr  Thr Cys Thr 
    1070                 1075                 1080             


Ala Gly  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Gly  Ala Cys Cys 
    1085                 1090                 1095             


Ala Thr  Cys Thr Cys Cys Ala  Ala Cys Gly Cys Cys  Ala Cys Ala 
    1100                 1105                 1110             


Gly Gly  Cys Cys Ala Gly Cys  Cys Cys Ala Gly Ala  Gly Ala Gly 
    1115                 1120                 1125             


Cys Cys  Thr Cys Ala Gly Gly  Thr Gly Thr Ala Thr  Ala Cys Cys 
    1130                 1135                 1140             


Cys Thr  Gly Cys Cys Cys Cys  Cys Thr Ala Gly Cys  Cys Ala Gly 
    1145                 1150                 1155             


Gly Ala  Gly Gly Ala Gly Ala  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1160                 1165                 1170             


Ala Ala  Thr Cys Ala Gly Gly  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1175                 1180                 1185             


Ala Cys  Ala Thr Gly Thr Cys  Thr Gly Gly Thr Gly  Ala Ala Gly 
    1190                 1195                 1200             


Gly Gly  Cys Thr Thr Cys Thr  Ala Cys Cys Cys Thr  Thr Cys Cys 
    1205                 1210                 1215             


Gly Ala  Thr Ala Thr Cys Gly  Cys Cys Gly Thr Gly  Gly Ala Gly 
    1220                 1225                 1230             


Thr Gly  Gly Gly Ala Gly Thr  Cys Thr Ala Ala Cys  Gly Gly Cys 
    1235                 1240                 1245             


Cys Ala  Gly Cys Cys Ala Gly  Ala Gly Ala Ala Cys  Ala Ala Thr 
    1250                 1255                 1260             


Thr Ala  Thr Ala Ala Gly Ala  Cys Cys Ala Cys Ala  Cys Cys Ala 
    1265                 1270                 1275             


Cys Cys  Cys Gly Thr Gly Cys  Thr Gly Gly Ala Cys  Ala Gly Cys 
    1280                 1285                 1290             


Gly Ala  Thr Gly Gly Cys Thr  Cys Cys Thr Thr Cys  Thr Thr Thr 
    1295                 1300                 1305             


Cys Thr  Gly Thr Ala Cys Thr  Cys Thr Ala Gly Gly  Cys Thr Gly 
    1310                 1315                 1320             


Ala Cys  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Gly  Ala Gly Cys 
    1325                 1330                 1335             


Cys Gly  Cys Thr Gly Gly Cys  Ala Gly Gly Ala Gly  Gly Gly Cys 
    1340                 1345                 1350             


Ala Ala  Cys Gly Thr Gly Thr  Thr Thr Thr Cys Thr  Thr Gly Cys 
    1355                 1360                 1365             


Ala Gly  Cys Gly Thr Gly Cys  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1370                 1375                 1380             


Gly Cys  Cys Cys Thr Gly Cys  Ala Cys Ala Ala Thr  Cys Ala Cys 
    1385                 1390                 1395             


Thr Ala  Cys Ala Cys Ala Cys  Ala Gly Ala Ala Gly  Thr Cys Cys 
    1400                 1405                 1410             


Cys Thr  Gly Thr Cys Thr Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1415                 1420                 1425             


Gly Gly  Cys Ala Ala Gly Gly  Ala Thr Gly Ala Gly  Gly Gly Ala 
    1430                 1435                 1440             


Gly Gly  Ala Gly Ala Gly Gly  Ala Cys Gly Gly Ala  Ala Gly Cys 
    1445                 1450                 1455             


Gly Ala  Thr Ala Thr Cys Cys  Ala Gly Ala Thr Gly  Ala Cys Cys 
    1460                 1465                 1470             


Cys Ala  Gly Ala Cys Cys Ala  Cys Ala Thr Cys Cys  Thr Cys Thr 
    1475                 1480                 1485             


Cys Thr  Gly Thr Cys Cys Gly  Cys Cys Thr Cys Thr  Cys Thr Gly 
    1490                 1495                 1500             


Gly Gly  Cys Gly Ala Cys Ala  Gly Gly Gly Thr Gly  Ala Cys Ala 
    1505                 1510                 1515             


Ala Thr  Cys Thr Cys Cys Thr  Gly Thr Cys Gly Cys  Gly Cys Cys 
    1520                 1525                 1530             


Thr Cys  Thr Cys Ala Gly Gly  Ala Thr Ala Thr Cys  Ala Gly Cys 
    1535                 1540                 1545             


Ala Ala  Gly Thr Ala Thr Cys  Thr Gly Ala Ala Thr  Thr Gly Gly 
    1550                 1555                 1560             


Thr Ala  Thr Cys Ala Gly Cys  Ala Gly Ala Ala Gly  Cys Cys Thr 
    1565                 1570                 1575             


Gly Ala  Cys Gly Gly Cys Ala  Cys Cys Gly Thr Gly  Ala Ala Gly 
    1580                 1585                 1590             


Cys Thr  Gly Cys Thr Gly Ala  Thr Cys Thr Ala Thr  Cys Ala Cys 
    1595                 1600                 1605             


Ala Cys  Ala Thr Cys Cys Cys  Gly Gly Cys Thr Gly  Cys Ala Cys 
    1610                 1615                 1620             


Thr Cys  Thr Gly Gly Cys Gly  Thr Gly Cys Cys Ala  Ala Gly Cys 
    1625                 1630                 1635             


Ala Gly  Ala Thr Thr Cys Ala  Gly Cys Gly Gly Ala  Thr Cys Cys 
    1640                 1645                 1650             


Gly Gly  Ala Thr Cys Thr Gly  Gly Cys Ala Cys Cys  Gly Ala Cys 
    1655                 1660                 1665             


Thr Ala  Cys Thr Cys Cys Cys  Thr Gly Ala Cys Ala  Ala Thr Cys 
    1670                 1675                 1680             


Thr Cys  Thr Ala Ala Cys Cys  Thr Gly Gly Ala Gly  Cys Ala Gly 
    1685                 1690                 1695             


Gly Ala  Gly Gly Ala Thr Ala  Thr Cys Gly Cys Cys  Ala Cys Cys 
    1700                 1705                 1710             


Thr Ala  Thr Thr Thr Cys Thr  Gly Cys Cys Ala Gly  Cys Ala Gly 
    1715                 1720                 1725             


Gly Gly  Cys Ala Ala Thr Ala  Cys Cys Cys Thr Gly  Cys Cys Thr 
    1730                 1735                 1740             


Thr Ala  Cys Ala Cys Ala Thr  Thr Thr Gly Gly Cys  Gly Gly Cys 
    1745                 1750                 1755             


Gly Gly  Cys Ala Cys Cys Ala  Ala Gly Cys Thr Gly  Gly Ala Gly 
    1760                 1765                 1770             


Ala Thr  Cys Ala Cys Ala Gly  Gly Cys Gly Gly Ala  Gly Gly Ala 
    1775                 1780                 1785             


Ala Gly  Cys Gly Gly Ala Gly  Gly Ala Gly Gly Ala  Thr Cys Cys 
    1790                 1795                 1800             


Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Gly Ala Gly 
    1805                 1810                 1815             


Gly Thr  Gly Ala Ala Gly Cys  Thr Gly Cys Ala Gly  Gly Ala Gly 
    1820                 1825                 1830             


Ala Gly  Cys Gly Gly Ala Cys  Cys Thr Gly Gly Cys  Cys Thr Gly 
    1835                 1840                 1845             


Gly Thr  Gly Gly Cys Ala Cys  Cys Ala Ala Gly Cys  Cys Ala Gly 
    1850                 1855                 1860             


Thr Cys  Cys Cys Thr Gly Thr  Cys Thr Gly Thr Gly  Ala Cys Cys 
    1865                 1870                 1875             


Thr Gly  Thr Ala Cys Ala Gly  Thr Gly Thr Cys Thr  Gly Gly Cys 
    1880                 1885                 1890             


Gly Thr  Gly Ala Gly Cys Cys  Thr Gly Cys Cys Cys  Gly Ala Thr 
    1895                 1900                 1905             


Thr Ala  Cys Gly Gly Cys Gly  Thr Gly Thr Cys Thr  Thr Gly Gly 
    1910                 1915                 1920             


Ala Thr  Cys Ala Gly Gly Cys  Ala Gly Cys Cys Thr  Cys Cys Ala 
    1925                 1930                 1935             


Ala Gly  Gly Ala Ala Gly Gly  Gly Cys Cys Thr Gly  Gly Ala Gly 
    1940                 1945                 1950             


Thr Gly  Gly Cys Thr Gly Gly  Gly Cys Gly Thr Gly  Ala Thr Cys 
    1955                 1960                 1965             


Thr Gly  Gly Gly Gly Cys Ala  Gly Cys Gly Ala Gly  Ala Cys Ala 
    1970                 1975                 1980             


Ala Cys  Ala Thr Ala Cys Thr  Ala Thr Ala Ala Cys  Ala Gly Cys 
    1985                 1990                 1995             


Gly Cys  Cys Cys Thr Gly Ala  Ala Gly Thr Cys Cys  Cys Gly Gly 
    2000                 2005                 2010             


Cys Thr  Gly Ala Cys Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    2015                 2020                 2025             


Gly Ala  Cys Ala Ala Cys Ala  Gly Cys Ala Ala Gly  Thr Cys Cys 
    2030                 2035                 2040             


Cys Ala  Gly Gly Thr Gly Thr  Thr Cys Cys Thr Gly  Ala Ala Gly 
    2045                 2050                 2055             


Ala Thr  Gly Ala Ala Thr Thr  Cys Cys Cys Thr Gly  Cys Ala Gly 
    2060                 2065                 2070             


Ala Cys  Cys Gly Ala Cys Gly  Ala Thr Ala Cys Ala  Gly Cys Cys 
    2075                 2080                 2085             


Ala Thr  Cys Thr Ala Cys Thr  Ala Thr Thr Gly Thr  Gly Cys Cys 
    2090                 2095                 2100             


Ala Ala  Gly Cys Ala Cys Thr  Ala Cys Thr Ala Thr  Thr Ala Cys 
    2105                 2110                 2115             


Gly Gly  Cys Gly Gly Cys Thr  Cys Thr Thr Ala Thr  Gly Cys Cys 
    2120                 2125                 2130             


Ala Thr  Gly Gly Ala Thr Thr  Ala Cys Thr Gly Gly  Gly Gly Cys 
    2135                 2140                 2145             


Cys Ala  Gly Gly Gly Cys Ala  Cys Cys Ala Gly Cys  Gly Thr Gly 
    2150                 2155                 2160             


Ala Cys  Ala Gly Thr Gly Ala  Gly Cys Thr Cys Cys  Thr Gly Ala 
    2165                 2170                 2175             


<210>  77
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln 
465                 470                 475                 480 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                485                 490                 495     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
            500                 505                 510         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
        515                 520                 525             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    530                 535                 540                 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
545                 550                 555                 560 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
                565                 570                 575     


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
        595                 600                 605             


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
    610                 615                 620                 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
625                 630                 635                 640 


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
                645                 650                 655     


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
            660                 665                 670         


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
        675                 680                 685             


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
    690                 695                 700                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
705                 710                 715     


<210>  78
<211>  2151
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Thr Gly Gly Ala Gly Thr Thr Thr Gly Gly Cys Cys Thr Gly Thr 
1               5                   10                  15      


Cys Thr Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Thr Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Ala 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Thr Cys Ala Gly Thr Thr Cys Ala 
    50                  55                  60                  


Thr Cys Gly Thr Thr Gly Thr Gly Gly Gly Ala Cys Cys Thr Ala Cys 
65                  70                  75                  80  


Cys Gly Ala Thr Cys Cys Thr Ala Thr Cys Thr Thr Gly Gly Cys Thr 
                85                  90                  95      


Ala Cys Ala Gly Thr Gly Gly Gly Cys Gly Ala Gly Ala Ala Thr Ala 
            100                 105                 110         


Cys Ala Ala Cys Cys Cys Thr Gly Ala Gly Ala Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Thr Thr Gly Thr Cys Thr Cys Cys Thr Gly Ala Gly Ala Ala Gly 
    130                 135                 140                 


Ala Ala Cys Gly Cys Cys Gly Ala Gly Gly Ala Thr Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Gly Thr Thr Ala Gly Gly Thr Gly Gly Thr Thr Cys Ala Gly 
                165                 170                 175     


Ala Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Cys Cys Thr 
            180                 185                 190         


Gly Cys Cys Gly Thr Gly Thr Thr Thr Gly Thr Gly Thr Ala Thr Ala 
        195                 200                 205             


Ala Gly Gly Gly Ala Gly Gly Cys Ala Gly Ala Gly Ala Gly Ala Gly 
    210                 215                 220                 


Ala Ala Cys Ala Gly Ala Ala Gly Ala Gly Cys Ala Gly Ala Thr Gly 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Gly Thr Ala Cys Ala Gly Ala Gly Gly Ala Ala 
                245                 250                 255     


Gly Ala Ala Cys Cys Ala Cys Cys Thr Thr Cys Gly Thr Gly Thr Cys 
            260                 265                 270         


Thr Ala Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Gly Ala 
        275                 280                 285             


Gly Gly Cys Thr Cys Thr Gly Thr Gly Gly Cys Thr Cys Thr Gly Gly 
    290                 295                 300                 


Thr Gly Ala Thr Cys Cys Ala Cys Ala Ala Thr Ala Thr Cys Ala Cys 
305                 310                 315                 320 


Ala Gly Cys Thr Cys Ala Gly Gly Ala Gly Ala Ala Thr Gly Gly Cys 
                325                 330                 335     


Ala Cys Cys Thr Ala Cys Ala Gly Ala Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Thr Cys Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Gly Thr Cys 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Thr Gly Ala Gly Gly Cys Thr Ala Thr Thr 
    370                 375                 380                 


Thr Thr Gly Cys Ala Thr Cys Thr Gly Gly Thr Gly Gly Thr Thr Gly 
385                 390                 395                 400 


Cys Thr Gly Gly Ala Cys Thr Gly Gly Gly Ala Thr Cys Thr Ala Ala 
                405                 410                 415     


Ala Cys Cys Thr Cys Thr Gly Ala Thr Cys Ala Gly Cys Ala Thr Gly 
            420                 425                 430         


Ala Gly Gly Gly Gly Ala Cys Ala Cys Gly Ala Gly Gly Ala Thr Gly 
        435                 440                 445             


Gly Ala Gly Gly Ala Ala Thr Thr Ala Gly Ala Cys Thr Gly Gly Ala 
    450                 455                 460                 


Gly Thr Gly Cys Ala Thr Cys Thr Cys Thr Ala Gly Ala Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Thr Ala Ala Ala Cys Cys Ala Cys 
                485                 490                 495     


Thr Gly Ala Cys Ala Gly Thr Gly Thr Gly Gly Ala Gly Ala Gly Ala 
            500                 505                 510         


Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Gly Gly Ala Gly Thr Thr 
        515                 520                 525             


Gly Cys Thr Cys Cys Thr Gly Cys Thr Cys Thr Gly Ala Ala Ala Gly 
    530                 535                 540                 


Ala Gly Gly Thr Gly Thr Cys Thr Ala Thr Gly Cys Cys Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Cys Thr Gly Ala Thr Gly Gly Cys Cys Thr Gly Thr Thr Thr 
                565                 570                 575     


Ala Thr Gly Gly Thr Gly Ala Cys Ala Ala Cys Ala Gly Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Cys Cys Gly Gly Gly Ala Cys Ala Ala 
        595                 600                 605             


Ala Thr Cys Cys Gly Thr Gly Ala Gly Gly Ala Ala Cys Ala Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Gly Cys Thr Cys Cys Ala Thr Cys Ala Ala Cys Ala 
625                 630                 635                 640 


Ala Cys Ala Cys Ala Cys Thr Gly Thr Thr Gly Gly Gly Ala Cys Ala 
                645                 650                 655     


Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Ala Gly Cys Gly Thr Gly 
            660                 665                 670         


Ala Thr Cys Thr Thr Cys Ala Thr Cys Cys Cys Cys Gly Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Thr Gly Cys Cys Thr Ala Gly Cys Gly Thr 
    690                 695                 700                 


Thr Thr Cys Thr Cys Cys Thr Thr Gly Thr Gly Cys Thr Gly Ala Ala 
705                 710                 715                 720 


Cys Cys Thr Ala Ala Gly Thr Cys Thr Thr Gly Cys Gly Ala Cys Ala 
                725                 730                 735     


Ala Gly Ala Cys Cys Cys Ala Thr Ala Cys Ala Thr Gly Cys Cys Cys 
            740                 745                 750         


Thr Cys Cys Thr Thr Gly Thr Cys Cys Thr Gly Cys Thr Cys Cys Thr 
        755                 760                 765             


Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Ala Cys 
    770                 775                 780                 


Cys Thr Thr Cys Thr Gly Thr Gly Thr Thr Thr Thr Thr Gly Thr Thr 
785                 790                 795                 800 


Thr Cys Cys Thr Cys Cys Thr Ala Ala Gly Cys Cys Thr Ala Ala Gly 
                805                 810                 815     


Gly Ala Thr Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Thr 
            820                 825                 830         


Cys Cys Ala Gly Ala Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr 
        835                 840                 845             


Gly Ala Cys Cys Thr Gly Thr Gly Thr Gly Gly Thr Gly Gly Thr Thr 
    850                 855                 860                 


Gly Ala Thr Gly Thr Thr Thr Cys Thr Cys Ala Thr Gly Ala Gly Gly 
865                 870                 875                 880 


Ala Thr Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Ala Gly Thr Thr 
                885                 890                 895     


Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys 
            900                 905                 910         


Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala 
        915                 920                 925             


Ala Cys Gly Cys Thr Ala Ala Gly Ala Cys Ala Ala Ala Ala Cys Cys 
    930                 935                 940                 


Thr Ala Gly Ala Gly Ala Ala Gly Ala Gly Cys Ala Gly Thr Ala Cys 
945                 950                 955                 960 


Ala Ala Cys Thr Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly 
                965                 970                 975     


Thr Gly Gly Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys 
            980                 985                 990         


Cys Gly Thr Gly Cys Thr Gly Cys  Ala Cys Cys Ala Ala  Gly Ala Thr 
        995                 1000                 1005             


Thr Gly  Gly Thr Thr Gly Ala  Ala Thr Gly Gly Ala  Ala Ala Gly 
    1010                 1015                 1020             


Gly Ala  Gly Thr Ala Cys Ala  Ala Gly Thr Gly Cys  Ala Ala Gly 
    1025                 1030                 1035             


Gly Thr  Gly Thr Cys Cys Ala  Ala Cys Ala Ala Gly  Gly Cys Thr 
    1040                 1045                 1050             


Cys Thr  Gly Cys Cys Thr Gly  Cys Cys Cys Cys Thr  Ala Thr Cys 
    1055                 1060                 1065             


Gly Ala  Gly Ala Ala Gly Ala  Cys Cys Ala Thr Cys  Thr Cys Thr 
    1070                 1075                 1080             


Ala Ala  Gly Gly Cys Thr Ala  Ala Ala Gly Gly Ala  Cys Ala Ala 
    1085                 1090                 1095             


Cys Cys  Thr Ala Gly Ala Gly  Ala Ala Cys Cys Thr  Cys Ala Gly 
    1100                 1105                 1110             


Gly Thr  Gly Thr Ala Thr Ala  Cys Cys Cys Thr Gly  Cys Cys Thr 
    1115                 1120                 1125             


Cys Cys  Cys Thr Gly Cys Ala  Gly Ala Gly Ala Thr  Gly Ala Gly 
    1130                 1135                 1140             


Cys Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Thr  Cys Ala Gly 
    1145                 1150                 1155             


Gly Thr  Thr Thr Cys Thr Cys  Thr Gly Thr Gly Gly  Thr Gly Thr 
    1160                 1165                 1170             


Cys Thr  Gly Gly Thr Gly Ala  Ala Gly Gly Gly Cys  Thr Thr Thr 
    1175                 1180                 1185             


Thr Ala  Cys Cys Cys Thr Ala  Gly Cys Gly Ala Cys  Ala Thr Cys 
    1190                 1195                 1200             


Gly Cys  Thr Gly Thr Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly 
    1205                 1210                 1215             


Thr Cys  Thr Ala Ala Thr Gly  Gly Ala Cys Ala Ala  Cys Cys Thr 
    1220                 1225                 1230             


Gly Ala  Gly Ala Ala Cys Ala  Ala Cys Thr Ala Cys  Ala Ala Gly 
    1235                 1240                 1245             


Ala Cys  Cys Ala Cys Ala Cys  Cys Thr Cys Cys Thr  Gly Thr Gly 
    1250                 1255                 1260             


Cys Thr  Gly Gly Ala Cys Thr  Cys Thr Gly Ala Thr  Gly Gly Cys 
    1265                 1270                 1275             


Thr Cys  Cys Thr Thr Cys Thr  Thr Cys Cys Thr Gly  Thr Ala Cys 
    1280                 1285                 1290             


Thr Cys  Thr Ala Ala Gly Cys  Thr Gly Ala Cys Cys  Gly Thr Gly 
    1295                 1300                 1305             


Gly Ala  Thr Ala Ala Gly Thr  Cys Thr Ala Gly Ala  Thr Gly Gly 
    1310                 1315                 1320             


Cys Ala  Ala Cys Ala Gly Gly  Gly Cys Ala Ala Cys  Gly Thr Gly 
    1325                 1330                 1335             


Thr Thr  Cys Thr Cys Cys Thr  Gly Cys Thr Cys Cys  Gly Thr Gly 
    1340                 1345                 1350             


Ala Thr  Gly Cys Ala Thr Gly  Ala Ala Gly Cys Thr  Cys Thr Gly 
    1355                 1360                 1365             


Cys Ala  Cys Ala Ala Cys Cys  Ala Cys Thr Ala Thr  Ala Cys Ala 
    1370                 1375                 1380             


Cys Ala  Gly Ala Ala Gly Thr  Cys Thr Cys Thr Gly  Ala Gly Cys 
    1385                 1390                 1395             


Cys Thr  Gly Thr Cys Thr Cys  Cys Thr Gly Gly Cys  Ala Ala Gly 
    1400                 1405                 1410             


Ala Thr  Cys Gly Ala Gly Gly  Gly Cys Ala Gly Ala  Ala Thr Gly 
    1415                 1420                 1425             


Gly Ala  Cys Gly Ala Thr Ala  Thr Cys Cys Ala Gly  Ala Thr Gly 
    1430                 1435                 1440             


Ala Cys  Ala Cys Ala Gly Ala  Cys Ala Ala Cys Cys  Thr Cys Thr 
    1445                 1450                 1455             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Gly Cys Thr  Thr Cys Thr 
    1460                 1465                 1470             


Cys Thr  Gly Gly Gly Cys Gly  Ala Thr Ala Gly Ala  Gly Thr Gly 
    1475                 1480                 1485             


Ala Cys  Cys Ala Thr Cys Ala  Gly Cys Thr Gly Cys  Ala Gly Ala 
    1490                 1495                 1500             


Gly Cys  Thr Thr Cys Thr Cys  Ala Gly Gly Ala Cys  Ala Thr Cys 
    1505                 1510                 1515             


Ala Gly  Cys Ala Ala Gly Thr  Ala Thr Cys Thr Gly  Ala Ala Cys 
    1520                 1525                 1530             


Thr Gly  Gly Thr Ala Thr Cys  Ala Gly Cys Ala Gly  Ala Ala Gly 
    1535                 1540                 1545             


Cys Cys  Thr Gly Ala Thr Gly  Gly Cys Ala Cys Cys  Gly Thr Gly 
    1550                 1555                 1560             


Ala Ala  Gly Cys Thr Gly Cys  Thr Gly Ala Thr Cys  Thr Ala Cys 
    1565                 1570                 1575             


Cys Ala  Cys Ala Cys Cys Thr  Cys Cys Ala Gly Ala  Thr Thr Gly 
    1580                 1585                 1590             


Cys Ala  Thr Thr Cys Thr Gly  Gly Ala Gly Thr Thr  Cys Cys Thr 
    1595                 1600                 1605             


Thr Cys  Cys Ala Gly Ala Thr  Thr Thr Thr Cys Thr  Gly Gly Cys 
    1610                 1615                 1620             


Thr Cys  Thr Gly Gly Cys Thr  Cys Thr Gly Gly Cys  Ala Cys Cys 
    1625                 1630                 1635             


Gly Ala  Cys Thr Ala Thr Thr  Cys Thr Cys Thr Gly  Ala Cys Cys 
    1640                 1645                 1650             


Ala Thr  Cys Ala Gly Cys Ala  Ala Thr Cys Thr Gly  Gly Ala Ala 
    1655                 1660                 1665             


Cys Ala  Gly Gly Ala Gly Gly  Ala Cys Ala Thr Cys  Gly Cys Thr 
    1670                 1675                 1680             


Ala Cys  Cys Thr Ala Cys Thr  Thr Thr Thr Gly Cys  Cys Ala Gly 
    1685                 1690                 1695             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Ala Cys Ala  Cys Thr Gly 
    1700                 1705                 1710             


Cys Cys  Thr Thr Ala Cys Ala  Cys Ala Thr Thr Thr  Gly Gly Ala 
    1715                 1720                 1725             


Gly Gly  Ala Gly Gly Ala Ala  Cys Ala Ala Ala Gly  Cys Thr Gly 
    1730                 1735                 1740             


Gly Ala  Gly Ala Thr Cys Ala  Cys Ala Gly Gly Ala  Gly Gly Ala 
    1745                 1750                 1755             


Gly Gly  Ala Thr Cys Thr Gly  Gly Ala Gly Gly Ala  Gly Gly Ala 
    1760                 1765                 1770             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    1775                 1780                 1785             


Gly Ala  Ala Gly Thr Thr Ala  Ala Ala Cys Thr Gly  Cys Ala Gly 
    1790                 1795                 1800             


Gly Ala  Ala Thr Cys Thr Gly  Gly Ala Cys Cys Ala  Gly Gly Ala 
    1805                 1810                 1815             


Thr Thr  Ala Gly Thr Gly Gly  Cys Cys Cys Cys Ala  Thr Cys Thr 
    1820                 1825                 1830             


Cys Ala  Gly Thr Cys Thr Cys  Thr Gly Thr Cys Thr  Gly Thr Gly 
    1835                 1840                 1845             


Ala Cys  Cys Thr Gly Thr Ala  Cys Cys Gly Thr Thr  Thr Cys Thr 
    1850                 1855                 1860             


Gly Gly  Ala Gly Thr Thr Thr  Cys Thr Thr Thr Gly  Cys Cys Thr 
    1865                 1870                 1875             


Gly Ala  Thr Thr Ala Cys Gly  Gly Ala Gly Thr Gly  Thr Cys Cys 
    1880                 1885                 1890             


Thr Gly  Gly Ala Thr Cys Ala  Gly Ala Cys Ala Gly  Cys Cys Cys 
    1895                 1900                 1905             


Cys Cys  Thr Ala Gly Ala Ala  Ala Gly Gly Gly Ala  Cys Thr Gly 
    1910                 1915                 1920             


Gly Ala  Ala Thr Gly Gly Thr  Thr Ala Gly Gly Ala  Gly Thr Gly 
    1925                 1930                 1935             


Ala Thr  Thr Thr Gly Gly Gly  Gly Ala Thr Cys Thr  Gly Ala Gly 
    1940                 1945                 1950             


Ala Cys  Cys Ala Cys Cys Thr  Ala Cys Thr Ala Cys  Ala Ala Cys 
    1955                 1960                 1965             


Thr Cys  Thr Gly Cys Cys Cys  Thr Gly Ala Ala Gly  Ala Gly Cys 
    1970                 1975                 1980             


Ala Gly  Ala Cys Thr Gly Ala  Cys Cys Ala Thr Cys  Ala Thr Cys 
    1985                 1990                 1995             


Ala Ala  Gly Gly Ala Cys Ala  Ala Cys Ala Gly Cys  Ala Ala Gly 
    2000                 2005                 2010             


Thr Cys  Thr Cys Ala Gly Gly  Thr Gly Thr Thr Cys  Cys Thr Gly 
    2015                 2020                 2025             


Ala Ala  Gly Ala Thr Gly Ala  Ala Cys Thr Cys Cys  Cys Thr Gly 
    2030                 2035                 2040             


Cys Ala  Gly Ala Cys Cys Gly  Ala Cys Gly Ala Thr  Ala Cys Cys 
    2045                 2050                 2055             


Gly Cys  Cys Ala Thr Cys Thr  Ala Cys Thr Ala Cys  Thr Gly Thr 
    2060                 2065                 2070             


Gly Cys  Thr Ala Ala Gly Cys  Ala Cys Thr Ala Cys  Thr Ala Cys 
    2075                 2080                 2085             


Thr Ala  Thr Gly Gly Cys Gly  Gly Cys Thr Cys Thr  Thr Ala Thr 
    2090                 2095                 2100             


Gly Cys  Cys Ala Thr Gly Gly  Ala Cys Thr Ala Thr  Thr Gly Gly 
    2105                 2110                 2115             


Gly Gly  Ala Cys Ala Gly Gly  Gly Cys Ala Cys Cys  Thr Cys Thr 
    2120                 2125                 2130             


Gly Thr  Gly Ala Cys Ala Gly  Thr Gly Thr Cys Thr  Thr Cys Thr 
    2135                 2140                 2145             


Thr Ala  Ala 
    2150     


<210>  79
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln 
465                 470                 475                 480 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                485                 490                 495     


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
            500                 505                 510         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
        515                 520                 525             


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    530                 535                 540                 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
545                 550                 555                 560 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
                565                 570                 575     


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
        595                 600                 605             


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
    610                 615                 620                 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
625                 630                 635                 640 


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
                645                 650                 655     


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
            660                 665                 670         


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
        675                 680                 685             


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
    690                 695                 700                 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
705                 710                 715     


<210>  80
<211>  2151
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Thr Gly Gly Ala Gly Thr Thr Thr Gly Gly Cys Cys Thr Gly Thr 
1               5                   10                  15      


Cys Thr Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Thr Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Ala 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Thr Cys Ala Gly Thr Thr Cys Ala 
    50                  55                  60                  


Thr Cys Gly Thr Thr Gly Thr Gly Gly Gly Ala Cys Cys Thr Ala Cys 
65                  70                  75                  80  


Cys Gly Ala Thr Cys Cys Thr Ala Thr Cys Thr Thr Gly Gly Cys Thr 
                85                  90                  95      


Ala Cys Ala Gly Thr Gly Gly Gly Cys Gly Ala Gly Ala Ala Thr Ala 
            100                 105                 110         


Cys Ala Ala Cys Cys Cys Thr Gly Ala Gly Ala Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Thr Thr Gly Thr Cys Thr Cys Cys Thr Gly Ala Gly Ala Ala Gly 
    130                 135                 140                 


Ala Ala Cys Gly Cys Cys Gly Ala Gly Gly Ala Thr Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Gly Thr Thr Ala Gly Gly Thr Gly Gly Thr Thr Cys Ala Gly 
                165                 170                 175     


Ala Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Cys Cys Thr 
            180                 185                 190         


Gly Cys Cys Gly Thr Gly Thr Thr Thr Gly Thr Gly Thr Ala Thr Ala 
        195                 200                 205             


Ala Gly Gly Gly Ala Gly Gly Cys Ala Gly Ala Gly Ala Gly Ala Gly 
    210                 215                 220                 


Ala Ala Cys Ala Gly Ala Ala Gly Ala Gly Cys Ala Gly Ala Thr Gly 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Gly Thr Ala Cys Ala Gly Ala Gly Gly Ala Ala 
                245                 250                 255     


Gly Ala Ala Cys Cys Ala Cys Cys Thr Thr Cys Gly Thr Gly Thr Cys 
            260                 265                 270         


Thr Ala Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Gly Ala 
        275                 280                 285             


Gly Gly Cys Thr Cys Thr Gly Thr Gly Gly Cys Thr Cys Thr Gly Gly 
    290                 295                 300                 


Thr Gly Ala Thr Cys Cys Ala Cys Ala Ala Thr Ala Thr Cys Ala Cys 
305                 310                 315                 320 


Ala Gly Cys Thr Cys Ala Gly Gly Ala Gly Ala Ala Thr Gly Gly Cys 
                325                 330                 335     


Ala Cys Cys Thr Ala Cys Ala Gly Ala Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Thr Cys Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Gly Thr Cys 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Thr Gly Ala Gly Gly Cys Thr Ala Thr Thr 
    370                 375                 380                 


Thr Thr Gly Cys Ala Thr Cys Thr Gly Gly Thr Gly Gly Thr Thr Gly 
385                 390                 395                 400 


Cys Thr Gly Gly Ala Cys Thr Gly Gly Gly Ala Thr Cys Thr Ala Ala 
                405                 410                 415     


Ala Cys Cys Thr Cys Thr Gly Ala Thr Cys Ala Gly Cys Ala Thr Gly 
            420                 425                 430         


Ala Gly Gly Gly Gly Ala Cys Ala Cys Gly Ala Gly Gly Ala Thr Gly 
        435                 440                 445             


Gly Ala Gly Gly Ala Ala Thr Thr Ala Gly Ala Cys Thr Gly Gly Ala 
    450                 455                 460                 


Gly Thr Gly Cys Ala Thr Cys Thr Cys Thr Ala Gly Ala Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Thr Ala Ala Ala Cys Cys Ala Cys 
                485                 490                 495     


Thr Gly Ala Cys Ala Gly Thr Gly Thr Gly Gly Ala Gly Ala Gly Ala 
            500                 505                 510         


Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Gly Gly Ala Gly Thr Thr 
        515                 520                 525             


Gly Cys Thr Cys Cys Thr Gly Cys Thr Cys Thr Gly Ala Ala Ala Gly 
    530                 535                 540                 


Ala Gly Gly Thr Gly Thr Cys Thr Ala Thr Gly Cys Cys Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Cys Thr Gly Ala Thr Gly Gly Cys Cys Thr Gly Thr Thr Thr 
                565                 570                 575     


Ala Thr Gly Gly Thr Gly Ala Cys Ala Ala Cys Ala Gly Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Cys Cys Gly Gly Gly Ala Cys Ala Ala 
        595                 600                 605             


Ala Thr Cys Cys Gly Thr Gly Ala Gly Gly Ala Ala Cys Ala Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Gly Cys Thr Cys Cys Ala Thr Cys Ala Ala Cys Ala 
625                 630                 635                 640 


Ala Cys Ala Cys Ala Cys Thr Gly Thr Thr Gly Gly Gly Ala Cys Ala 
                645                 650                 655     


Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Ala Gly Cys Gly Thr Gly 
            660                 665                 670         


Ala Thr Cys Thr Thr Cys Ala Thr Cys Cys Cys Cys Gly Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Thr Gly Cys Cys Thr Ala Gly Cys Gly Thr 
    690                 695                 700                 


Thr Thr Cys Thr Cys Cys Thr Thr Gly Thr Gly Cys Thr Gly Ala Ala 
705                 710                 715                 720 


Cys Cys Thr Ala Ala Gly Thr Cys Thr Thr Gly Cys Gly Ala Cys Ala 
                725                 730                 735     


Ala Gly Ala Cys Cys Cys Ala Thr Ala Cys Ala Thr Gly Cys Cys Cys 
            740                 745                 750         


Thr Cys Cys Thr Thr Gly Thr Cys Cys Thr Gly Cys Thr Cys Cys Thr 
        755                 760                 765             


Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Ala Cys 
    770                 775                 780                 


Cys Thr Thr Cys Thr Gly Thr Gly Thr Thr Thr Thr Thr Gly Thr Thr 
785                 790                 795                 800 


Thr Cys Cys Thr Cys Cys Thr Ala Ala Gly Cys Cys Thr Ala Ala Gly 
                805                 810                 815     


Gly Ala Thr Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Thr 
            820                 825                 830         


Cys Cys Ala Gly Ala Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr 
        835                 840                 845             


Gly Ala Cys Cys Thr Gly Thr Gly Thr Gly Gly Thr Gly Gly Thr Thr 
    850                 855                 860                 


Gly Ala Thr Gly Thr Thr Thr Cys Thr Cys Ala Thr Gly Ala Gly Gly 
865                 870                 875                 880 


Ala Thr Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Ala Gly Thr Thr 
                885                 890                 895     


Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys 
            900                 905                 910         


Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala 
        915                 920                 925             


Ala Cys Gly Cys Thr Ala Ala Gly Ala Cys Ala Ala Ala Ala Cys Cys 
    930                 935                 940                 


Thr Ala Gly Ala Gly Ala Ala Gly Ala Gly Cys Ala Gly Thr Ala Cys 
945                 950                 955                 960 


Ala Ala Cys Thr Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly 
                965                 970                 975     


Thr Gly Gly Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys 
            980                 985                 990         


Cys Gly Thr Gly Cys Thr Gly Cys  Ala Cys Cys Ala Ala  Gly Ala Thr 
        995                 1000                 1005             


Thr Gly  Gly Thr Thr Gly Ala  Ala Thr Gly Gly Ala  Ala Ala Gly 
    1010                 1015                 1020             


Gly Ala  Gly Thr Ala Cys Ala  Ala Gly Thr Gly Cys  Ala Ala Gly 
    1025                 1030                 1035             


Gly Thr  Gly Thr Cys Cys Ala  Ala Cys Ala Ala Gly  Gly Cys Thr 
    1040                 1045                 1050             


Cys Thr  Gly Cys Cys Thr Gly  Cys Cys Cys Cys Thr  Ala Thr Cys 
    1055                 1060                 1065             


Gly Ala  Gly Ala Ala Gly Ala  Cys Cys Ala Thr Cys  Thr Cys Thr 
    1070                 1075                 1080             


Ala Ala  Gly Gly Cys Thr Ala  Ala Ala Gly Gly Ala  Cys Ala Ala 
    1085                 1090                 1095             


Cys Cys  Thr Ala Gly Ala Gly  Ala Ala Cys Cys Thr  Cys Ala Gly 
    1100                 1105                 1110             


Gly Thr  Gly Thr Ala Thr Ala  Cys Cys Cys Thr Gly  Cys Cys Thr 
    1115                 1120                 1125             


Cys Cys  Cys Thr Gly Cys Ala  Gly Ala Gly Ala Thr  Gly Ala Gly 
    1130                 1135                 1140             


Cys Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Thr  Cys Ala Gly 
    1145                 1150                 1155             


Gly Thr  Thr Thr Cys Thr Cys  Thr Gly Thr Gly Gly  Thr Gly Thr 
    1160                 1165                 1170             


Cys Thr  Gly Gly Thr Gly Ala  Ala Gly Gly Gly Cys  Thr Thr Thr 
    1175                 1180                 1185             


Thr Ala  Cys Cys Cys Thr Ala  Gly Cys Gly Ala Cys  Ala Thr Cys 
    1190                 1195                 1200             


Gly Cys  Thr Gly Thr Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly 
    1205                 1210                 1215             


Thr Cys  Thr Ala Ala Thr Gly  Gly Ala Cys Ala Ala  Cys Cys Thr 
    1220                 1225                 1230             


Gly Ala  Gly Ala Ala Cys Ala  Ala Cys Thr Ala Cys  Ala Ala Gly 
    1235                 1240                 1245             


Ala Cys  Cys Ala Cys Ala Cys  Cys Thr Cys Cys Thr  Gly Thr Gly 
    1250                 1255                 1260             


Cys Thr  Gly Gly Ala Cys Thr  Cys Thr Gly Ala Thr  Gly Gly Cys 
    1265                 1270                 1275             


Thr Cys  Cys Thr Thr Cys Thr  Thr Cys Cys Thr Gly  Thr Ala Cys 
    1280                 1285                 1290             


Thr Cys  Thr Ala Ala Gly Cys  Thr Gly Ala Cys Cys  Gly Thr Gly 
    1295                 1300                 1305             


Gly Ala  Thr Ala Ala Gly Thr  Cys Thr Ala Gly Ala  Thr Gly Gly 
    1310                 1315                 1320             


Cys Ala  Ala Cys Ala Gly Gly  Gly Cys Ala Ala Cys  Gly Thr Gly 
    1325                 1330                 1335             


Thr Thr  Cys Thr Cys Cys Thr  Gly Cys Thr Cys Thr  Gly Thr Gly 
    1340                 1345                 1350             


Cys Thr  Gly Cys Ala Thr Gly  Ala Ala Gly Cys Thr  Cys Thr Gly 
    1355                 1360                 1365             


Cys Ala  Cys Thr Cys Thr Cys  Ala Cys Thr Ala Thr  Ala Cys Ala 
    1370                 1375                 1380             


Cys Ala  Gly Ala Ala Gly Thr  Cys Thr Cys Thr Gly  Thr Cys Cys 
    1385                 1390                 1395             


Cys Thr  Gly Thr Cys Thr Cys  Cys Thr Gly Gly Cys  Ala Ala Gly 
    1400                 1405                 1410             


Ala Thr  Cys Gly Ala Gly Gly  Gly Cys Ala Gly Ala  Ala Thr Gly 
    1415                 1420                 1425             


Gly Ala  Cys Gly Ala Thr Ala  Thr Cys Cys Ala Gly  Ala Thr Gly 
    1430                 1435                 1440             


Ala Cys  Ala Cys Ala Gly Ala  Cys Ala Ala Cys Cys  Thr Cys Thr 
    1445                 1450                 1455             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Gly Cys Thr  Thr Cys Thr 
    1460                 1465                 1470             


Cys Thr  Gly Gly Gly Cys Gly  Ala Thr Ala Gly Ala  Gly Thr Gly 
    1475                 1480                 1485             


Ala Cys  Cys Ala Thr Cys Ala  Gly Cys Thr Gly Cys  Ala Gly Ala 
    1490                 1495                 1500             


Gly Cys  Thr Thr Cys Thr Cys  Ala Gly Gly Ala Cys  Ala Thr Cys 
    1505                 1510                 1515             


Ala Gly  Cys Ala Ala Gly Thr  Ala Thr Cys Thr Gly  Ala Ala Cys 
    1520                 1525                 1530             


Thr Gly  Gly Thr Ala Thr Cys  Ala Gly Cys Ala Gly  Ala Ala Gly 
    1535                 1540                 1545             


Cys Cys  Thr Gly Ala Thr Gly  Gly Cys Ala Cys Cys  Gly Thr Gly 
    1550                 1555                 1560             


Ala Ala  Gly Cys Thr Gly Cys  Thr Gly Ala Thr Cys  Thr Ala Cys 
    1565                 1570                 1575             


Cys Ala  Cys Ala Cys Cys Thr  Cys Cys Ala Gly Ala  Thr Thr Gly 
    1580                 1585                 1590             


Cys Ala  Thr Thr Cys Thr Gly  Gly Ala Gly Thr Thr  Cys Cys Thr 
    1595                 1600                 1605             


Thr Cys  Cys Ala Gly Ala Thr  Thr Thr Thr Cys Thr  Gly Gly Cys 
    1610                 1615                 1620             


Thr Cys  Thr Gly Gly Cys Thr  Cys Thr Gly Gly Cys  Ala Cys Cys 
    1625                 1630                 1635             


Gly Ala  Cys Thr Ala Thr Thr  Cys Thr Cys Thr Gly  Ala Cys Cys 
    1640                 1645                 1650             


Ala Thr  Cys Ala Gly Cys Ala  Ala Thr Cys Thr Gly  Gly Ala Ala 
    1655                 1660                 1665             


Cys Ala  Gly Gly Ala Gly Gly  Ala Cys Ala Thr Cys  Gly Cys Thr 
    1670                 1675                 1680             


Ala Cys  Cys Thr Ala Cys Thr  Thr Thr Thr Gly Cys  Cys Ala Gly 
    1685                 1690                 1695             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Ala Cys Ala  Cys Thr Gly 
    1700                 1705                 1710             


Cys Cys  Thr Thr Ala Cys Ala  Cys Ala Thr Thr Thr  Gly Gly Ala 
    1715                 1720                 1725             


Gly Gly  Ala Gly Gly Ala Ala  Cys Ala Ala Ala Gly  Cys Thr Gly 
    1730                 1735                 1740             


Gly Ala  Gly Ala Thr Cys Ala  Cys Ala Gly Gly Ala  Gly Gly Ala 
    1745                 1750                 1755             


Gly Gly  Ala Thr Cys Thr Gly  Gly Ala Gly Gly Ala  Gly Gly Ala 
    1760                 1765                 1770             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    1775                 1780                 1785             


Gly Ala  Ala Gly Thr Thr Ala  Ala Ala Cys Thr Gly  Cys Ala Gly 
    1790                 1795                 1800             


Gly Ala  Ala Thr Cys Thr Gly  Gly Ala Cys Cys Ala  Gly Gly Ala 
    1805                 1810                 1815             


Thr Thr  Ala Gly Thr Gly Gly  Cys Cys Cys Cys Ala  Thr Cys Thr 
    1820                 1825                 1830             


Cys Ala  Gly Thr Cys Thr Cys  Thr Gly Thr Cys Thr  Gly Thr Gly 
    1835                 1840                 1845             


Ala Cys  Cys Thr Gly Thr Ala  Cys Cys Gly Thr Thr  Thr Cys Thr 
    1850                 1855                 1860             


Gly Gly  Ala Gly Thr Thr Thr  Cys Thr Thr Thr Gly  Cys Cys Thr 
    1865                 1870                 1875             


Gly Ala  Thr Thr Ala Cys Gly  Gly Ala Gly Thr Gly  Thr Cys Cys 
    1880                 1885                 1890             


Thr Gly  Gly Ala Thr Cys Ala  Gly Ala Cys Ala Gly  Cys Cys Cys 
    1895                 1900                 1905             


Cys Cys  Thr Ala Gly Ala Ala  Ala Gly Gly Gly Ala  Cys Thr Gly 
    1910                 1915                 1920             


Gly Ala  Ala Thr Gly Gly Thr  Thr Ala Gly Gly Ala  Gly Thr Gly 
    1925                 1930                 1935             


Ala Thr  Thr Thr Gly Gly Gly  Gly Ala Thr Cys Thr  Gly Ala Gly 
    1940                 1945                 1950             


Ala Cys  Cys Ala Cys Cys Thr  Ala Cys Thr Ala Cys  Ala Ala Cys 
    1955                 1960                 1965             


Thr Cys  Thr Gly Cys Cys Cys  Thr Gly Ala Ala Gly  Ala Gly Cys 
    1970                 1975                 1980             


Ala Gly  Ala Cys Thr Gly Ala  Cys Cys Ala Thr Cys  Ala Thr Cys 
    1985                 1990                 1995             


Ala Ala  Gly Gly Ala Cys Ala  Ala Cys Ala Gly Cys  Ala Ala Gly 
    2000                 2005                 2010             


Thr Cys  Thr Cys Ala Gly Gly  Thr Gly Thr Thr Cys  Cys Thr Gly 
    2015                 2020                 2025             


Ala Ala  Gly Ala Thr Gly Ala  Ala Cys Thr Cys Cys  Cys Thr Gly 
    2030                 2035                 2040             


Cys Ala  Gly Ala Cys Cys Gly  Ala Cys Gly Ala Thr  Ala Cys Cys 
    2045                 2050                 2055             


Gly Cys  Cys Ala Thr Cys Thr  Ala Cys Thr Ala Cys  Thr Gly Thr 
    2060                 2065                 2070             


Gly Cys  Thr Ala Ala Gly Cys  Ala Cys Thr Ala Cys  Thr Ala Cys 
    2075                 2080                 2085             


Thr Ala  Thr Gly Gly Cys Gly  Gly Cys Thr Cys Thr  Thr Ala Thr 
    2090                 2095                 2100             


Gly Cys  Cys Ala Thr Gly Gly  Ala Cys Thr Ala Thr  Thr Gly Gly 
    2105                 2110                 2115             


Gly Gly  Ala Cys Ala Gly Gly  Gly Cys Ala Cys Cys  Thr Cys Thr 
    2120                 2125                 2130             


Gly Thr  Gly Ala Cys Ala Gly  Thr Gly Thr Cys Thr  Thr Cys Thr 
    2135                 2140                 2145             


Thr Ala  Ala 
    2150     


<210>  81
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Asp Ile Gln 
                485                 490                 495     


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
            500                 505                 510         


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
        515                 520                 525             


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
    530                 535                 540                 


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
545                 550                 555                 560 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
                565                 570                 575     


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
            580                 585                 590         


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
    610                 615                 620                 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
625                 630                 635                 640 


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
                645                 650                 655     


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
            660                 665                 670         


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
        675                 680                 685             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
    690                 695                 700                 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
705                 710                 715                 720 


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                725                 730         


<210>  82
<211>  2199
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Thr Gly Gly Ala Gly Thr Thr Cys Gly Gly Cys Cys Thr Gly Thr 
1               5                   10                  15      


Cys Cys Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Cys Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Cys Cys Ala Gly Thr Thr Cys Thr 
    50                  55                  60                  


Cys Cys Gly Thr Gly Cys Thr Gly Gly Gly Cys Cys Cys Thr Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Cys Cys Cys Ala Ala Thr Cys Cys Thr Gly Gly Cys Ala 
                85                  90                  95      


Ala Thr Gly Gly Thr Gly Gly Gly Ala Gly Ala Gly Gly Ala Cys Gly 
            100                 105                 110         


Cys Ala Gly Ala Thr Cys Thr Gly Cys Cys Ala Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Cys Thr Gly Thr Thr Thr Cys Cys Cys Ala Cys Cys Ala Thr Gly 
    130                 135                 140                 


Ala Gly Cys Gly Cys Cys Gly Ala Gly Ala Cys Ala Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Cys Thr Gly Ala Ala Gly Thr Gly Gly Gly Thr Gly Ala Gly 
                165                 170                 175     


Cys Thr Cys Cys Thr Cys Thr Cys Thr Gly Cys Gly Gly Cys Ala Gly 
            180                 185                 190         


Gly Thr Gly Gly Thr Gly Ala Ala Cys Gly Thr Gly Thr Ala Cys Gly 
        195                 200                 205             


Cys Cys Gly Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Gly Ala Gly Gly Ala Thr Ala Gly Ala Cys Ala Gly Thr Cys Cys 
225                 230                 235                 240 


Gly Cys Cys Cys Cys Cys Thr Ala Cys Cys Gly Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Ala Ala Cys Cys Thr Cys Thr Ala Thr Cys Cys Thr Gly Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Gly Gly Ala Ala Thr Cys Ala Cys Ala Gly Cys Ala 
        275                 280                 285             


Gly Gly Cys Ala Ala Gly Gly Cys Cys Gly Cys Cys Cys Thr Gly Ala 
    290                 295                 300                 


Gly Ala Ala Thr Cys Cys Ala Cys Ala Ala Cys Gly Thr Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Cys Cys Ala Gly Cys Gly Ala Thr Thr Cys Cys Gly Gly Cys 
                325                 330                 335     


Ala Ala Gly Thr Ala Thr Cys Thr Gly Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Cys Cys Ala Gly Gly Ala Cys Gly Gly Cys Gly Ala Cys Thr Thr 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Gly Cys Cys Cys Thr Gly 
    370                 375                 380                 


Gly Thr Gly Gly Ala Gly Cys Thr Gly Ala Ala Gly Gly Thr Gly Gly 
385                 390                 395                 400 


Cys Cys Gly Cys Cys Cys Thr Gly Gly Gly Ala Ala Gly Cys Gly Ala 
                405                 410                 415     


Cys Cys Thr Gly Cys Ala Thr Gly Thr Gly Gly Ala Thr Gly Thr Gly 
            420                 425                 430         


Ala Ala Gly Gly Gly Cys Thr Ala Thr Ala Ala Gly Gly Ala Cys Gly 
        435                 440                 445             


Gly Cys Gly Gly Cys Ala Thr Cys Cys Ala Cys Cys Thr Gly Gly Ala 
    450                 455                 460                 


Gly Thr Gly Thr Cys Gly Gly Ala Gly Cys Ala Cys Cys Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Cys Cys Ala Gly Cys Cys Thr Cys 
                485                 490                 495     


Ala Gly Ala Thr Cys Cys Ala Gly Thr Gly Gly Thr Cys Cys Ala Ala 
            500                 505                 510         


Cys Ala Ala Thr Ala Ala Gly Gly Gly Cys Gly Ala Gly Ala Ala Thr 
        515                 520                 525             


Ala Thr Cys Cys Cys Thr Ala Cys Ala Gly Thr Gly Gly Ala Gly Gly 
    530                 535                 540                 


Cys Cys Cys Cys Ala Gly Thr Gly Gly Thr Gly Gly Cys Ala Gly Ala 
545                 550                 555                 560 


Thr Gly Gly Ala Gly Thr Gly Gly Gly Cys Cys Thr Gly Thr Ala Cys 
                565                 570                 575     


Gly Cys Ala Gly Thr Gly Gly Cys Cys Gly Cys Cys Thr Cys Thr Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Gly Ala Gly Gly Gly Gly Ala Ala Gly 
        595                 600                 605             


Cys Thr Cys Cys Gly Gly Ala Gly Ala Gly Gly Gly Cys Gly Thr Gly 
    610                 615                 620                 


Ala Gly Cys Thr Gly Cys Ala Cys Cys Ala Thr Cys Cys Gly Cys Thr 
625                 630                 635                 640 


Cys Thr Ala Gly Cys Cys Thr Gly Cys Thr Gly Gly Gly Cys Cys Thr 
                645                 650                 655     


Gly Gly Ala Gly Ala Ala Gly Ala Cys Ala Gly Cys Cys Thr Cys Thr 
            660                 665                 670         


Ala Thr Cys Ala Gly Cys Ala Thr Cys Gly Cys Cys Gly Ala Cys Cys 
        675                 680                 685             


Cys Cys Thr Thr Cys Thr Thr Thr Ala Gly Gly Ala Gly Cys Gly Cys 
    690                 695                 700                 


Cys Cys Ala Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Gly Cys Cys 
705                 710                 715                 720 


Gly Cys Cys Cys Thr Gly Gly Cys Ala Gly Gly Cys Gly Gly Cys Thr 
                725                 730                 735     


Cys Cys Gly Gly Cys Thr Cys Thr Gly Ala Cys Gly Ala Gly Gly Gly 
            740                 745                 750         


Cys Gly Gly Cys Gly Ala Gly Gly Ala Thr Gly Gly Cys Thr Cys Cys 
        755                 760                 765             


Ala Ala Gly Thr Ala Thr Gly Gly Ala Cys Cys Ala Cys Cys Thr Thr 
    770                 775                 780                 


Gly Cys Cys Cys Ala Cys Cys Ala Thr Gly Thr Cys Cys Ala Gly Cys 
785                 790                 795                 800 


Ala Cys Cys Ala Gly Ala Gly Thr Thr Cys Cys Thr Gly Gly Gly Ala 
                805                 810                 815     


Gly Gly Ala Cys Cys Ala Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys 
            820                 825                 830         


Thr Gly Thr Thr Thr Cys Cys Thr Cys Cys Ala Ala Ala Gly Cys Cys 
        835                 840                 845             


Cys Ala Ala Gly Gly Ala Cys Cys Ala Gly Cys Thr Gly Ala Thr Gly 
    850                 855                 860                 


Ala Thr Cys Thr Cys Cys Ala Gly Gly Ala Cys Cys Cys Cys Ala Gly 
865                 870                 875                 880 


Ala Gly Gly Thr Gly Ala Cys Cys Thr Gly Cys Gly Thr Gly Gly Thr 
                885                 890                 895     


Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Thr Cys Thr Cys Ala Gly 
            900                 905                 910         


Gly Ala Gly Gly Ala Thr Cys Cys Thr Gly Ala Gly Gly Thr Gly Cys 
        915                 920                 925             


Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr 
    930                 935                 940                 


Gly Gly Ala Thr Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly 
945                 950                 955                 960 


Cys Ala Cys Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Cys Ala 
                965                 970                 975     


Ala Gly Cys Cys Thr Ala Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala 
            980                 985                 990         


Gly Thr Thr Thr Ala Ala Cys Ala  Gly Cys Ala Cys Cys  Thr Ala Thr 
        995                 1000                 1005             


Cys Gly  Cys Gly Thr Gly Gly  Thr Gly Thr Cys Cys  Gly Thr Gly 
    1010                 1015                 1020             


Cys Thr  Gly Ala Cys Ala Gly  Thr Gly Cys Thr Gly  Cys Ala Cys 
    1025                 1030                 1035             


Cys Ala  Gly Gly Ala Thr Thr  Gly Gly Cys Thr Gly  Thr Cys Cys 
    1040                 1045                 1050             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1055                 1060                 1065             


Thr Gly  Cys Ala Ala Gly Gly  Thr Gly Thr Cys Cys  Thr Cys Thr 
    1070                 1075                 1080             


Ala Ala  Gly Gly Gly Cys Cys  Thr Gly Cys Cys Ala  Ala Gly Cys 
    1085                 1090                 1095             


Thr Cys  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Gly  Ala Cys Cys 
    1100                 1105                 1110             


Ala Thr  Cys Ala Gly Cys Ala  Ala Cys Gly Cys Ala  Ala Cys Ala 
    1115                 1120                 1125             


Gly Gly  Cys Cys Ala Gly Cys  Cys Cys Cys Gly Cys  Gly Ala Gly 
    1130                 1135                 1140             


Cys Cys  Thr Cys Ala Gly Gly  Thr Gly Thr Ala Thr  Ala Cys Cys 
    1145                 1150                 1155             


Cys Thr  Gly Cys Cys Cys Cys  Cys Thr Thr Cys Thr  Cys Ala Gly 
    1160                 1165                 1170             


Gly Ala  Gly Gly Ala Gly Ala  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1175                 1180                 1185             


Ala Ala  Thr Cys Ala Gly Gly  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1190                 1195                 1200             


Ala Cys  Ala Thr Gly Thr Cys  Thr Gly Gly Thr Gly  Ala Ala Gly 
    1205                 1210                 1215             


Gly Gly  Cys Thr Thr Cys Thr  Ala Cys Cys Cys Thr  Ala Gly Cys 
    1220                 1225                 1230             


Gly Ala  Cys Ala Thr Cys Gly  Cys Ala Gly Thr Gly  Gly Ala Gly 
    1235                 1240                 1245             


Thr Gly  Gly Gly Ala Gly Thr  Cys Cys Ala Ala Cys  Gly Gly Ala 
    1250                 1255                 1260             


Cys Ala  Gly Cys Cys Ala Gly  Ala Gly Ala Ala Cys  Ala Ala Thr 
    1265                 1270                 1275             


Thr Ala  Thr Ala Ala Gly Ala  Cys Cys Ala Cys Ala  Cys Cys Ala 
    1280                 1285                 1290             


Cys Cys  Cys Gly Thr Gly Cys  Thr Gly Gly Ala Cys  Thr Cys Thr 
    1295                 1300                 1305             


Gly Ala  Thr Gly Gly Cys Ala  Gly Cys Thr Thr Cys  Thr Thr Thr 
    1310                 1315                 1320             


Cys Thr  Gly Thr Ala Cys Thr  Cys Thr Ala Gly Gly  Cys Thr Gly 
    1325                 1330                 1335             


Ala Cys  Cys Gly Thr Gly Gly  Ala Thr Ala Ala Gly  Ala Gly Cys 
    1340                 1345                 1350             


Cys Gly  Cys Thr Gly Gly Cys  Ala Gly Gly Ala Gly  Gly Gly Cys 
    1355                 1360                 1365             


Ala Ala  Cys Gly Thr Gly Thr  Thr Thr Ala Gly Cys  Thr Gly Cys 
    1370                 1375                 1380             


Thr Cys  Cys Gly Thr Gly Cys  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1385                 1390                 1395             


Gly Cys  Cys Cys Thr Gly Cys  Ala Cys Ala Ala Thr  Cys Ala Cys 
    1400                 1405                 1410             


Thr Ala  Cys Ala Cys Ala Cys  Ala Gly Ala Ala Gly  Thr Cys Thr 
    1415                 1420                 1425             


Cys Thr  Gly Ala Gly Cys Cys  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1430                 1435                 1440             


Gly Gly  Cys Ala Ala Gly Ala  Gly Gly Ala Ala Gly  Gly Gly Ala 
    1445                 1450                 1455             


Gly Gly  Cys Ala Ala Gly Ala  Gly Gly Gly Gly Ala  Thr Cys Thr 
    1460                 1465                 1470             


Gly Gly  Ala Ala Gly Cys Gly  Ala Cys Ala Thr Cys  Cys Ala Gly 
    1475                 1480                 1485             


Ala Thr  Gly Ala Cys Cys Cys  Ala Gly Ala Cys Cys  Ala Cys Ala 
    1490                 1495                 1500             


Thr Cys  Thr Ala Gly Cys Cys  Thr Gly Thr Cys Cys  Gly Cys Cys 
    1505                 1510                 1515             


Thr Cys  Thr Cys Thr Gly Gly  Gly Cys Gly Ala Cys  Cys Gly Gly 
    1520                 1525                 1530             


Gly Thr  Gly Ala Cys Ala Ala  Thr Cys Ala Gly Cys  Thr Gly Thr 
    1535                 1540                 1545             


Ala Gly  Ala Gly Cys Cys Thr  Cys Cys Cys Ala Gly  Gly Ala Thr 
    1550                 1555                 1560             


Ala Thr  Cys Thr Cys Thr Ala  Ala Gly Thr Ala Thr  Cys Thr Gly 
    1565                 1570                 1575             


Ala Ala  Thr Thr Gly Gly Thr  Ala Thr Cys Ala Gly  Cys Ala Gly 
    1580                 1585                 1590             


Ala Ala  Gly Cys Cys Ala Gly  Ala Thr Gly Gly Cys  Ala Cys Cys 
    1595                 1600                 1605             


Gly Thr  Gly Ala Ala Gly Cys  Thr Gly Cys Thr Gly  Ala Thr Cys 
    1610                 1615                 1620             


Thr Ala  Thr Cys Ala Cys Ala  Cys Ala Ala Gly Cys  Ala Gly Gly 
    1625                 1630                 1635             


Cys Thr  Gly Cys Ala Cys Thr  Cys Cys Gly Gly Cys  Gly Thr Gly 
    1640                 1645                 1650             


Cys Cys  Cys Thr Cys Thr Ala  Gly Ala Thr Thr Cys  Ala Gly Cys 
    1655                 1660                 1665             


Gly Gly  Ala Thr Cys Cys Gly  Gly Ala Thr Cys Thr  Gly Gly Cys 
    1670                 1675                 1680             


Ala Cys  Cys Gly Ala Cys Thr  Ala Cys Ala Gly Cys  Cys Thr Gly 
    1685                 1690                 1695             


Ala Cys  Ala Ala Thr Cys Thr  Cys Cys Ala Ala Cys  Cys Thr Gly 
    1700                 1705                 1710             


Gly Ala  Gly Cys Ala Gly Gly  Ala Gly Gly Ala Thr  Ala Thr Cys 
    1715                 1720                 1725             


Gly Cys  Cys Ala Cys Cys Thr  Ala Thr Thr Thr Cys  Thr Gly Cys 
    1730                 1735                 1740             


Cys Ala  Gly Cys Ala Gly Gly  Gly Cys Ala Ala Thr  Ala Cys Cys 
    1745                 1750                 1755             


Cys Thr  Gly Cys Cys Cys Thr  Ala Cys Ala Cys Ala  Thr Thr Thr 
    1760                 1765                 1770             


Gly Gly  Cys Gly Gly Cys Gly  Gly Cys Ala Cys Cys  Ala Ala Gly 
    1775                 1780                 1785             


Cys Thr  Gly Gly Ala Gly Ala  Thr Cys Ala Cys Ala  Gly Gly Cys 
    1790                 1795                 1800             


Gly Gly  Ala Gly Gly Ala Thr  Cys Thr Gly Gly Ala  Gly Gly Ala 
    1805                 1810                 1815             


Gly Gly  Ala Ala Gly Cys Gly  Gly Ala Gly Gly Ala  Gly Gly Cys 
    1820                 1825                 1830             


Thr Cys  Cys Gly Ala Gly Gly  Thr Gly Ala Ala Gly  Cys Thr Gly 
    1835                 1840                 1845             


Cys Ala  Gly Gly Ala Gly Thr  Cys Cys Gly Gly Ala  Cys Cys Ala 
    1850                 1855                 1860             


Gly Gly  Cys Cys Thr Gly Gly  Thr Gly Gly Cys Ala  Cys Cys Thr 
    1865                 1870                 1875             


Ala Gly  Cys Cys Ala Gly Thr  Cys Cys Cys Thr Gly  Thr Cys Thr 
    1880                 1885                 1890             


Gly Thr  Gly Ala Cys Cys Thr  Gly Thr Ala Cys Ala  Gly Thr Gly 
    1895                 1900                 1905             


Thr Cys  Cys Gly Gly Cys Gly  Thr Gly Thr Cys Thr  Cys Thr Gly 
    1910                 1915                 1920             


Cys Cys  Thr Gly Ala Cys Thr  Ala Cys Gly Gly Cys  Gly Thr Gly 
    1925                 1930                 1935             


Thr Cys  Cys Thr Gly Gly Ala  Thr Cys Cys Gly Gly  Cys Ala Gly 
    1940                 1945                 1950             


Cys Cys  Thr Cys Cys Ala Ala  Gly Ala Ala Ala Gly  Gly Gly Cys 
    1955                 1960                 1965             


Cys Thr  Gly Gly Ala Gly Thr  Gly Gly Cys Thr Gly  Gly Gly Cys 
    1970                 1975                 1980             


Gly Thr  Gly Ala Thr Cys Thr  Gly Gly Gly Gly Cys  Ala Gly Cys 
    1985                 1990                 1995             


Gly Ala  Gly Ala Cys Ala Ala  Cys Ala Thr Ala Cys  Thr Ala Thr 
    2000                 2005                 2010             


Ala Ala  Cys Thr Cys Thr Gly  Cys Cys Cys Thr Gly  Ala Ala Gly 
    2015                 2020                 2025             


Ala Gly  Cys Ala Gly Ala Cys  Thr Gly Ala Cys Cys  Ala Thr Cys 
    2030                 2035                 2040             


Ala Thr  Cys Ala Ala Gly Gly  Ala Cys Ala Ala Cys  Ala Gly Cys 
    2045                 2050                 2055             


Ala Ala  Gly Thr Cys Cys Cys  Ala Gly Gly Thr Gly  Thr Thr Thr 
    2060                 2065                 2070             


Cys Thr  Gly Ala Ala Gly Ala  Thr Gly Ala Ala Thr  Ala Gly Cys 
    2075                 2080                 2085             


Cys Thr  Gly Cys Ala Gly Ala  Cys Cys Gly Ala Cys  Gly Ala Thr 
    2090                 2095                 2100             


Ala Cys  Ala Gly Cys Cys Ala  Thr Cys Thr Ala Cys  Thr Ala Thr 
    2105                 2110                 2115             


Thr Gly  Cys Gly Cys Cys Ala  Ala Gly Cys Ala Cys  Thr Ala Cys 
    2120                 2125                 2130             


Thr Ala  Thr Thr Ala Cys Gly  Gly Cys Gly Gly Cys  Thr Cys Cys 
    2135                 2140                 2145             


Thr Ala  Thr Gly Cys Cys Ala  Thr Gly Gly Ala Thr  Thr Ala Cys 
    2150                 2155                 2160             


Thr Gly  Gly Gly Gly Cys Cys  Ala Gly Gly Gly Cys  Ala Cys Cys 
    2165                 2170                 2175             


Thr Cys  Thr Gly Thr Gly Ala  Cys Ala Gly Thr Gly  Thr Cys Cys 
    2180                 2185                 2190             


Thr Cys  Thr Thr Gly Ala 
    2195                 


<210>  83
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met 
465                 470                 475                 480 


Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
                485                 490                 495     


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys 
            500                 505                 510         


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        515                 520                 525             


Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    530                 535                 540                 


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
545                 550                 555                 560 


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                565                 570                 575     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
        595                 600                 605             


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
    610                 615                 620                 


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
625                 630                 635                 640 


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
            660                 665                 670         


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
        675                 680                 685             


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
    690                 695                 700                 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
705                 710                 715                 720 


<210>  84
<211>  2163
<212>  PRT
<213>  Homo sapiens

<400>  84

Ala Thr Gly Gly Ala Gly Thr Thr Thr Gly Gly Cys Cys Thr Gly Thr 
1               5                   10                  15      


Cys Thr Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Thr Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Ala 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Thr Cys Ala Gly Thr Thr Cys Thr 
    50                  55                  60                  


Cys Thr Gly Thr Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Ala Cys Cys Thr Ala Thr Cys Thr Thr Gly Gly Cys Thr 
                85                  90                  95      


Ala Thr Gly Gly Thr Gly Gly Gly Ala Gly Ala Ala Gly Ala Thr Gly 
            100                 105                 110         


Cys Thr Gly Ala Thr Cys Thr Gly Cys Cys Thr Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Cys Thr Gly Thr Thr Thr Cys Cys Thr Ala Cys Cys Ala Thr Gly 
    130                 135                 140                 


Thr Cys Thr Gly Cys Thr Gly Ala Gly Ala Cys Cys Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Cys Thr Gly Ala Ala Ala Thr Gly Gly Gly Thr Gly Thr Cys 
                165                 170                 175     


Cys Thr Cys Thr Thr Cys Thr Cys Thr Gly Ala Gly Ala Cys Ala Gly 
            180                 185                 190         


Gly Thr Gly Gly Thr Gly Ala Ala Thr Gly Thr Gly Thr Ala Cys Gly 
        195                 200                 205             


Cys Thr Gly Ala Thr Gly Gly Ala Ala Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Gly Ala Gly Gly Ala Cys Ala Gly Ala Cys Ala Ala Thr Cys Thr 
225                 230                 235                 240 


Gly Cys Cys Cys Cys Thr Thr Ala Thr Ala Gly Ala Gly Gly Ala Ala 
                245                 250                 255     


Gly Ala Ala Cys Cys Ala Gly Cys Ala Thr Cys Cys Thr Gly Ala Gly 
            260                 265                 270         


Ala Gly Ala Thr Gly Gly Cys Ala Thr Cys Ala Cys Ala Gly Cys Thr 
        275                 280                 285             


Gly Gly Ala Ala Ala Gly Gly Cys Thr Gly Cys Thr Cys Thr Gly Ala 
    290                 295                 300                 


Gly Ala Ala Thr Cys Cys Ala Cys Ala Ala Thr Gly Thr Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Cys Thr Thr Cys Thr Gly Ala Thr Thr Cys Thr Gly Gly Cys 
                325                 330                 335     


Ala Ala Gly Thr Ala Cys Cys Thr Gly Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Cys Cys Ala Gly Gly Ala Thr Gly Gly Cys Gly Ala Cys Thr Thr 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Gly Cys Thr Cys Thr Gly 
    370                 375                 380                 


Gly Thr Thr Gly Ala Gly Cys Thr Gly Ala Ala Ala Gly Thr Thr Gly 
385                 390                 395                 400 


Cys Thr Gly Cys Thr Thr Thr Gly Gly Gly Cys Thr Cys Thr Gly Ala 
                405                 410                 415     


Thr Cys Thr Gly Cys Ala Thr Gly Thr Thr Gly Ala Cys Gly Thr Gly 
            420                 425                 430         


Ala Ala Gly Gly Gly Cys Thr Ala Cys Ala Ala Gly Gly Ala Thr Gly 
        435                 440                 445             


Gly Ala Gly Gly Cys Ala Thr Cys Cys Ala Thr Cys Thr Gly Gly Ala 
    450                 455                 460                 


Ala Thr Gly Thr Ala Gly Ala Thr Cys Thr Ala Cys Cys Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys 
                485                 490                 495     


Ala Gly Ala Thr Thr Cys Ala Gly Thr Gly Gly Ala Gly Cys Ala Ala 
            500                 505                 510         


Cys Ala Ala Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Ala Ala Cys 
        515                 520                 525             


Ala Thr Cys Cys Cys Thr Ala Cys Ala Gly Thr Thr Gly Ala Ala Gly 
    530                 535                 540                 


Cys Cys Cys Cys Thr Gly Thr Thr Gly Thr Gly Gly Cys Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Gly Ala Gly Thr Thr Gly Gly Ala Cys Thr Gly Thr Ala Thr 
                565                 570                 575     


Gly Cys Thr Gly Thr Thr Gly Cys Thr Gly Cys Thr Ala Gly Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Gly Ala Gly Ala Gly Gly Ala Thr Cys 
        595                 600                 605             


Thr Thr Cys Thr Gly Gly Ala Gly Ala Ala Gly Gly Cys Gly Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Gly Cys Ala Cys Cys Ala Thr Cys Ala Gly Ala Thr 
625                 630                 635                 640 


Cys Thr Thr Cys Thr Cys Thr Gly Thr Thr Gly Gly Gly Ala Cys Thr 
                645                 650                 655     


Gly Gly Ala Gly Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala Gly Cys 
            660                 665                 670         


Ala Thr Cys Thr Cys Thr Ala Thr Cys Gly Cys Thr Gly Ala Cys Cys 
        675                 680                 685             


Cys Cys Thr Thr Cys Thr Thr Cys Ala Gly Ala Thr Cys Thr Gly Cys 
    690                 695                 700                 


Thr Cys Ala Ala Ala Gly Ala Thr Gly Gly Ala Thr Thr Gly Cys Thr 
705                 710                 715                 720 


Gly Cys Thr Cys Thr Gly Gly Cys Thr Gly Ala Gly Cys Cys Thr Ala 
                725                 730                 735     


Ala Gly Thr Cys Thr Thr Gly Cys Gly Ala Thr Ala Ala Gly Ala Cys 
            740                 745                 750         


Cys Cys Ala Cys Ala Cys Cys Thr Gly Thr Cys Cys Thr Cys Cys Thr 
        755                 760                 765             


Thr Gly Thr Cys Cys Thr Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly 
    770                 775                 780                 


Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Ala Cys Cys Thr Thr Cys 
785                 790                 795                 800 


Thr Gly Thr Gly Thr Thr Thr Thr Thr Gly Thr Thr Thr Cys Cys Thr 
                805                 810                 815     


Cys Cys Thr Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala Thr Ala 
            820                 825                 830         


Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Thr Cys Cys Ala Gly 
        835                 840                 845             


Ala Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys 
    850                 855                 860                 


Thr Gly Thr Gly Thr Gly Gly Thr Gly Gly Thr Thr Gly Ala Thr Gly 
865                 870                 875                 880 


Thr Thr Thr Cys Thr Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Cys 
                885                 890                 895     


Thr Gly Ala Ala Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala Cys 
            900                 905                 910         


Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly 
        915                 920                 925             


Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys 
    930                 935                 940                 


Thr Ala Ala Gly Ala Cys Ala Ala Ala Ala Cys Cys Thr Ala Gly Ala 
945                 950                 955                 960 


Gly Ala Ala Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Thr 
                965                 970                 975     


Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly Thr 
            980                 985                 990         


Gly Thr Cys Cys Gly Thr Gly Cys  Thr Gly Ala Cys Cys  Gly Thr Gly 
        995                 1000                 1005             


Cys Thr  Gly Cys Ala Cys Cys  Ala Ala Gly Ala Thr  Thr Gly Gly 
    1010                 1015                 1020             


Thr Thr  Gly Ala Ala Thr Gly  Gly Ala Ala Ala Gly  Gly Ala Gly 
    1025                 1030                 1035             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1040                 1045                 1050             


Thr Cys  Cys Ala Ala Cys Ala  Ala Gly Gly Cys Thr  Cys Thr Gly 
    1055                 1060                 1065             


Cys Cys  Thr Gly Cys Cys Cys  Cys Thr Ala Thr Cys  Gly Ala Gly 
    1070                 1075                 1080             


Ala Ala  Gly Ala Cys Cys Ala  Thr Cys Thr Cys Thr  Ala Ala Gly 
    1085                 1090                 1095             


Gly Cys  Thr Ala Ala Ala Gly  Gly Ala Cys Ala Ala  Cys Cys Thr 
    1100                 1105                 1110             


Ala Gly  Ala Gly Ala Ala Cys  Cys Thr Cys Ala Gly  Gly Thr Gly 
    1115                 1120                 1125             


Thr Gly  Thr Ala Cys Ala Cys  Thr Gly Cys Cys Cys  Cys Cys Cys 
    1130                 1135                 1140             


Thr Cys  Thr Ala Gly Ala Gly  Ala Thr Gly Ala Gly  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Ala Ala Gly Ala  Ala Thr Cys Ala Gly  Gly Thr Thr 
    1160                 1165                 1170             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Thr Gly Thr  Gly Cys Thr 
    1175                 1180                 1185             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Thr  Thr Ala Cys 
    1190                 1195                 1200             


Cys Cys  Cys Thr Cys Cys Gly  Ala Cys Ala Thr Cys  Gly Cys Thr 
    1205                 1210                 1215             


Gly Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Ala Gly  Thr Cys Thr 
    1220                 1225                 1230             


Ala Ala  Thr Gly Gly Ala Cys  Ala Ala Cys Cys Thr  Gly Ala Gly 
    1235                 1240                 1245             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1250                 1255                 1260             


Ala Cys  Ala Cys Cys Thr Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1265                 1270                 1275             


Gly Ala  Cys Thr Cys Thr Gly  Ala Cys Gly Gly Cys  Thr Cys Cys 
    1280                 1285                 1290             


Thr Thr  Cys Thr Thr Thr Cys  Thr Gly Gly Thr Gly  Thr Cys Thr 
    1295                 1300                 1305             


Ala Ala  Gly Cys Thr Gly Ala  Cys Ala Gly Thr Gly  Gly Ala Thr 
    1310                 1315                 1320             


Ala Ala  Gly Thr Cys Thr Ala  Gly Ala Thr Gly Gly  Cys Ala Ala 
    1325                 1330                 1335             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1340                 1345                 1350             


Ala Gly  Cys Thr Gly Cys Thr  Cys Cys Gly Thr Gly  Ala Thr Gly 
    1355                 1360                 1365             


Cys Ala  Thr Gly Ala Ala Gly  Cys Thr Cys Thr Gly  Cys Ala Cys 
    1370                 1375                 1380             


Ala Ala  Cys Cys Ala Cys Thr  Ala Thr Ala Cys Ala  Cys Ala Gly 
    1385                 1390                 1395             


Ala Ala  Gly Thr Cys Thr Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1400                 1405                 1410             


Thr Cys  Thr Cys Cys Thr Gly  Gly Cys Ala Ala Gly  Ala Thr Cys 
    1415                 1420                 1425             


Gly Ala  Gly Gly Gly Cys Ala  Gly Ala Ala Thr Gly  Gly Ala Cys 
    1430                 1435                 1440             


Gly Ala  Thr Ala Thr Cys Cys  Ala Gly Ala Thr Gly  Ala Cys Ala 
    1445                 1450                 1455             


Cys Ala  Gly Ala Cys Ala Ala  Cys Cys Thr Cys Thr  Thr Cys Thr 
    1460                 1465                 1470             


Cys Thr  Gly Thr Cys Thr Gly  Cys Thr Thr Cys Thr  Cys Thr Gly 
    1475                 1480                 1485             


Gly Gly  Cys Gly Ala Thr Ala  Gly Ala Gly Thr Gly  Ala Cys Cys 
    1490                 1495                 1500             


Ala Thr  Cys Ala Gly Cys Thr  Gly Cys Ala Gly Ala  Gly Cys Thr 
    1505                 1510                 1515             


Thr Cys  Thr Cys Ala Gly Gly  Ala Cys Ala Thr Cys  Ala Gly Cys 
    1520                 1525                 1530             


Ala Ala  Gly Thr Ala Thr Cys  Thr Gly Ala Ala Cys  Thr Gly Gly 
    1535                 1540                 1545             


Thr Ala  Thr Cys Ala Gly Cys  Ala Gly Ala Ala Gly  Cys Cys Thr 
    1550                 1555                 1560             


Gly Ala  Thr Gly Gly Cys Ala  Cys Cys Gly Thr Gly  Ala Ala Gly 
    1565                 1570                 1575             


Cys Thr  Gly Cys Thr Gly Ala  Thr Cys Thr Ala Cys  Cys Ala Cys 
    1580                 1585                 1590             


Ala Cys  Cys Thr Cys Cys Ala  Gly Ala Thr Thr Gly  Cys Ala Thr 
    1595                 1600                 1605             


Thr Cys  Thr Gly Gly Ala Gly  Thr Thr Cys Cys Thr  Thr Cys Cys 
    1610                 1615                 1620             


Ala Gly  Ala Thr Thr Thr Thr  Cys Thr Gly Gly Cys  Thr Cys Thr 
    1625                 1630                 1635             


Gly Gly  Cys Thr Cys Thr Gly  Gly Cys Ala Cys Cys  Gly Ala Cys 
    1640                 1645                 1650             


Thr Ala  Thr Thr Cys Thr Cys  Thr Gly Ala Cys Cys  Ala Thr Cys 
    1655                 1660                 1665             


Ala Gly  Cys Ala Ala Thr Cys  Thr Gly Gly Ala Ala  Cys Ala Gly 
    1670                 1675                 1680             


Gly Ala  Gly Gly Ala Cys Ala  Thr Cys Gly Cys Thr  Ala Cys Cys 
    1685                 1690                 1695             


Thr Ala  Cys Thr Thr Thr Thr  Gly Cys Cys Ala Gly  Cys Ala Gly 
    1700                 1705                 1710             


Gly Gly  Cys Ala Ala Cys Ala  Cys Ala Cys Thr Gly  Cys Cys Thr 
    1715                 1720                 1725             


Thr Ala  Cys Ala Cys Ala Thr  Thr Thr Gly Gly Ala  Gly Gly Ala 
    1730                 1735                 1740             


Gly Gly  Ala Ala Cys Ala Ala  Ala Gly Cys Thr Gly  Gly Ala Gly 
    1745                 1750                 1755             


Ala Thr  Cys Ala Cys Ala Gly  Gly Ala Gly Gly Ala  Gly Gly Ala 
    1760                 1765                 1770             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    1775                 1780                 1785             


Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Gly Ala Ala 
    1790                 1795                 1800             


Gly Thr  Thr Ala Ala Ala Cys  Thr Gly Cys Ala Gly  Gly Ala Ala 
    1805                 1810                 1815             


Thr Cys  Thr Gly Gly Ala Cys  Cys Ala Gly Gly Ala  Thr Thr Ala 
    1820                 1825                 1830             


Gly Thr  Gly Gly Cys Cys Cys  Cys Ala Thr Cys Thr  Cys Ala Gly 
    1835                 1840                 1845             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Gly Thr Gly  Ala Cys Cys 
    1850                 1855                 1860             


Thr Gly  Thr Ala Cys Cys Gly  Thr Thr Thr Cys Thr  Gly Gly Ala 
    1865                 1870                 1875             


Gly Thr  Thr Thr Cys Thr Thr  Thr Gly Cys Cys Thr  Gly Ala Thr 
    1880                 1885                 1890             


Thr Ala  Cys Gly Gly Ala Gly  Thr Gly Thr Cys Cys  Thr Gly Gly 
    1895                 1900                 1905             


Ala Thr  Cys Ala Gly Ala Cys  Ala Gly Cys Cys Cys  Cys Cys Thr 
    1910                 1915                 1920             


Ala Gly  Ala Ala Ala Gly Gly  Gly Ala Cys Thr Gly  Gly Ala Ala 
    1925                 1930                 1935             


Thr Gly  Gly Thr Thr Ala Gly  Gly Ala Gly Thr Gly  Ala Thr Thr 
    1940                 1945                 1950             


Thr Gly  Gly Gly Gly Ala Thr  Cys Thr Gly Ala Gly  Ala Cys Cys 
    1955                 1960                 1965             


Ala Cys  Cys Thr Ala Cys Thr  Ala Cys Ala Ala Cys  Thr Cys Thr 
    1970                 1975                 1980             


Gly Cys  Cys Cys Thr Gly Ala  Ala Gly Ala Gly Cys  Ala Gly Ala 
    1985                 1990                 1995             


Cys Thr  Gly Ala Cys Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    2000                 2005                 2010             


Gly Ala  Cys Ala Ala Cys Ala  Gly Cys Ala Ala Gly  Thr Cys Thr 
    2015                 2020                 2025             


Cys Ala  Gly Gly Thr Gly Thr  Thr Cys Cys Thr Gly  Ala Ala Gly 
    2030                 2035                 2040             


Ala Thr  Gly Ala Ala Cys Thr  Cys Cys Cys Thr Gly  Cys Ala Gly 
    2045                 2050                 2055             


Ala Cys  Cys Gly Ala Cys Gly  Ala Thr Ala Cys Cys  Gly Cys Cys 
    2060                 2065                 2070             


Ala Thr  Cys Thr Ala Cys Thr  Ala Cys Thr Gly Thr  Gly Cys Thr 
    2075                 2080                 2085             


Ala Ala  Gly Cys Ala Cys Thr  Ala Cys Thr Ala Cys  Thr Ala Thr 
    2090                 2095                 2100             


Gly Gly  Cys Gly Gly Cys Thr  Cys Thr Thr Ala Thr  Gly Cys Cys 
    2105                 2110                 2115             


Ala Thr  Gly Gly Ala Cys Thr  Ala Thr Thr Gly Gly  Gly Gly Ala 
    2120                 2125                 2130             


Cys Ala  Gly Gly Gly Cys Ala  Cys Cys Thr Cys Thr  Gly Thr Gly 
    2135                 2140                 2145             


Ala Cys  Ala Gly Thr Gly Thr  Cys Thr Thr Cys Thr  Thr Ala Ala 
    2150                 2155                 2160             


<210>  85
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met 
465                 470                 475                 480 


Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
                485                 490                 495     


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys 
            500                 505                 510         


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        515                 520                 525             


Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    530                 535                 540                 


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
545                 550                 555                 560 


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                565                 570                 575     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
        595                 600                 605             


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
    610                 615                 620                 


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
625                 630                 635                 640 


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
                645                 650                 655     


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
            660                 665                 670         


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
        675                 680                 685             


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
    690                 695                 700                 


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
705                 710                 715                 720 


<210>  86
<211>  2163
<212>  PRT
<213>  Homo sapiens

<400>  86

Ala Thr Gly Gly Ala Gly Thr Thr Thr Gly Gly Cys Cys Thr Gly Thr 
1               5                   10                  15      


Cys Thr Thr Gly Gly Gly Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Thr Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Gly Ala 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Thr Cys Ala Gly Thr Thr Cys Thr 
    50                  55                  60                  


Cys Thr Gly Thr Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Ala Cys Cys Thr Ala Thr Cys Thr Thr Gly Gly Cys Thr 
                85                  90                  95      


Ala Thr Gly Gly Thr Gly Gly Gly Ala Gly Ala Ala Gly Ala Thr Gly 
            100                 105                 110         


Cys Thr Gly Ala Thr Cys Thr Gly Cys Cys Thr Thr Gly Thr Cys Ala 
        115                 120                 125             


Cys Cys Thr Gly Thr Thr Thr Cys Cys Thr Ala Cys Cys Ala Thr Gly 
    130                 135                 140                 


Thr Cys Thr Gly Cys Thr Gly Ala Gly Ala Cys Cys Ala Thr Gly Gly 
145                 150                 155                 160 


Ala Gly Cys Thr Gly Ala Ala Ala Thr Gly Gly Gly Thr Gly Thr Cys 
                165                 170                 175     


Cys Thr Cys Thr Thr Cys Thr Cys Thr Gly Ala Gly Ala Cys Ala Gly 
            180                 185                 190         


Gly Thr Gly Gly Thr Gly Ala Ala Thr Gly Thr Gly Thr Ala Cys Gly 
        195                 200                 205             


Cys Thr Gly Ala Thr Gly Gly Ala Ala Ala Gly Gly Ala Gly Gly Thr 
    210                 215                 220                 


Gly Gly Ala Gly Gly Ala Cys Ala Gly Ala Cys Ala Ala Thr Cys Thr 
225                 230                 235                 240 


Gly Cys Cys Cys Cys Thr Thr Ala Thr Ala Gly Ala Gly Gly Ala Ala 
                245                 250                 255     


Gly Ala Ala Cys Cys Ala Gly Cys Ala Thr Cys Cys Thr Gly Ala Gly 
            260                 265                 270         


Ala Gly Ala Thr Gly Gly Cys Ala Thr Cys Ala Cys Ala Gly Cys Thr 
        275                 280                 285             


Gly Gly Ala Ala Ala Gly Gly Cys Thr Gly Cys Thr Cys Thr Gly Ala 
    290                 295                 300                 


Gly Ala Ala Thr Cys Cys Ala Cys Ala Ala Thr Gly Thr Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Cys Thr Thr Cys Thr Gly Ala Thr Thr Cys Thr Gly Gly Cys 
                325                 330                 335     


Ala Ala Gly Thr Ala Cys Cys Thr Gly Thr Gly Cys Thr Ala Cys Thr 
            340                 345                 350         


Thr Cys Cys Ala Gly Gly Ala Thr Gly Gly Cys Gly Ala Cys Thr Thr 
        355                 360                 365             


Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Gly Cys Thr Cys Thr Gly 
    370                 375                 380                 


Gly Thr Thr Gly Ala Gly Cys Thr Gly Ala Ala Ala Gly Thr Thr Gly 
385                 390                 395                 400 


Cys Thr Gly Cys Thr Thr Thr Gly Gly Gly Cys Thr Cys Thr Gly Ala 
                405                 410                 415     


Thr Cys Thr Gly Cys Ala Thr Gly Thr Thr Gly Ala Cys Gly Thr Gly 
            420                 425                 430         


Ala Ala Gly Gly Gly Cys Thr Ala Cys Ala Ala Gly Gly Ala Thr Gly 
        435                 440                 445             


Gly Ala Gly Gly Cys Ala Thr Cys Cys Ala Thr Cys Thr Gly Gly Ala 
    450                 455                 460                 


Ala Thr Gly Thr Ala Gly Ala Thr Cys Thr Ala Cys Cys Gly Gly Cys 
465                 470                 475                 480 


Thr Gly Gly Thr Ala Thr Cys Cys Thr Cys Ala Ala Cys Cys Thr Cys 
                485                 490                 495     


Ala Gly Ala Thr Thr Cys Ala Gly Thr Gly Gly Ala Gly Cys Ala Ala 
            500                 505                 510         


Cys Ala Ala Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly Ala Ala Cys 
        515                 520                 525             


Ala Thr Cys Cys Cys Thr Ala Cys Ala Gly Thr Thr Gly Ala Ala Gly 
    530                 535                 540                 


Cys Cys Cys Cys Thr Gly Thr Thr Gly Thr Gly Gly Cys Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Gly Ala Gly Thr Thr Gly Gly Ala Cys Thr Gly Thr Ala Thr 
                565                 570                 575     


Gly Cys Thr Gly Thr Thr Gly Cys Thr Gly Cys Thr Ala Gly Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Ala Thr Gly Ala Gly Ala Gly Gly Ala Thr Cys 
        595                 600                 605             


Thr Thr Cys Thr Gly Gly Ala Gly Ala Ala Gly Gly Cys Gly Thr Gly 
    610                 615                 620                 


Thr Cys Thr Thr Gly Cys Ala Cys Cys Ala Thr Cys Ala Gly Ala Thr 
625                 630                 635                 640 


Cys Thr Thr Cys Thr Cys Thr Gly Thr Thr Gly Gly Gly Ala Cys Thr 
                645                 650                 655     


Gly Gly Ala Gly Ala Ala Gly Ala Cys Cys Gly Cys Thr Ala Gly Cys 
            660                 665                 670         


Ala Thr Cys Thr Cys Thr Ala Thr Cys Gly Cys Thr Gly Ala Cys Cys 
        675                 680                 685             


Cys Cys Thr Thr Cys Thr Thr Cys Ala Gly Ala Thr Cys Thr Gly Cys 
    690                 695                 700                 


Thr Cys Ala Ala Ala Gly Ala Thr Gly Gly Ala Thr Thr Gly Cys Thr 
705                 710                 715                 720 


Gly Cys Thr Cys Thr Gly Gly Cys Thr Gly Ala Gly Cys Cys Thr Ala 
                725                 730                 735     


Ala Gly Thr Cys Thr Thr Gly Cys Gly Ala Thr Ala Ala Gly Ala Cys 
            740                 745                 750         


Cys Cys Ala Cys Ala Cys Cys Thr Gly Thr Cys Cys Thr Cys Cys Thr 
        755                 760                 765             


Thr Gly Thr Cys Cys Thr Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly 
    770                 775                 780                 


Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Ala Cys Cys Thr Thr Cys 
785                 790                 795                 800 


Thr Gly Thr Gly Thr Thr Thr Thr Thr Gly Thr Thr Thr Cys Cys Thr 
                805                 810                 815     


Cys Cys Thr Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala Thr Ala 
            820                 825                 830         


Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Thr Cys Cys Ala Gly 
        835                 840                 845             


Ala Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys 
    850                 855                 860                 


Thr Gly Thr Gly Thr Gly Gly Thr Gly Gly Thr Thr Gly Ala Thr Gly 
865                 870                 875                 880 


Thr Thr Thr Cys Thr Cys Ala Thr Gly Ala Gly Gly Ala Thr Cys Cys 
                885                 890                 895     


Thr Gly Ala Ala Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala Cys 
            900                 905                 910         


Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly 
        915                 920                 925             


Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys 
    930                 935                 940                 


Thr Ala Ala Gly Ala Cys Ala Ala Ala Ala Cys Cys Thr Ala Gly Ala 
945                 950                 955                 960 


Gly Ala Ala Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Thr 
                965                 970                 975     


Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly Thr 
            980                 985                 990         


Gly Thr Cys Cys Gly Thr Gly Cys  Thr Gly Ala Cys Cys  Gly Thr Gly 
        995                 1000                 1005             


Cys Thr  Gly Cys Ala Cys Cys  Ala Ala Gly Ala Thr  Thr Gly Gly 
    1010                 1015                 1020             


Thr Thr  Gly Ala Ala Thr Gly  Gly Ala Ala Ala Gly  Gly Ala Gly 
    1025                 1030                 1035             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1040                 1045                 1050             


Thr Cys  Cys Ala Ala Cys Ala  Ala Gly Gly Cys Thr  Cys Thr Gly 
    1055                 1060                 1065             


Cys Cys  Thr Gly Cys Cys Cys  Cys Thr Ala Thr Cys  Gly Ala Gly 
    1070                 1075                 1080             


Ala Ala  Gly Ala Cys Cys Ala  Thr Cys Thr Cys Thr  Ala Ala Gly 
    1085                 1090                 1095             


Gly Cys  Thr Ala Ala Ala Gly  Gly Ala Cys Ala Ala  Cys Cys Thr 
    1100                 1105                 1110             


Ala Gly  Ala Gly Ala Ala Cys  Cys Thr Cys Ala Gly  Gly Thr Gly 
    1115                 1120                 1125             


Thr Gly  Thr Ala Cys Ala Cys  Thr Gly Cys Cys Cys  Cys Cys Cys 
    1130                 1135                 1140             


Thr Cys  Thr Ala Gly Ala Gly  Ala Thr Gly Ala Gly  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Ala Ala Gly Ala  Ala Thr Cys Ala Gly  Gly Thr Thr 
    1160                 1165                 1170             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Thr Gly Thr  Gly Cys Thr 
    1175                 1180                 1185             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Thr  Thr Ala Cys 
    1190                 1195                 1200             


Cys Cys  Cys Thr Cys Cys Gly  Ala Cys Ala Thr Cys  Gly Cys Thr 
    1205                 1210                 1215             


Gly Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Ala Gly  Thr Cys Thr 
    1220                 1225                 1230             


Ala Ala  Thr Gly Gly Ala Cys  Ala Ala Cys Cys Thr  Gly Ala Gly 
    1235                 1240                 1245             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1250                 1255                 1260             


Ala Cys  Ala Cys Cys Thr Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1265                 1270                 1275             


Gly Ala  Cys Thr Cys Thr Gly  Ala Cys Gly Gly Cys  Thr Cys Cys 
    1280                 1285                 1290             


Thr Thr  Cys Thr Thr Thr Cys  Thr Gly Gly Thr Gly  Thr Cys Thr 
    1295                 1300                 1305             


Ala Ala  Gly Cys Thr Gly Ala  Cys Ala Gly Thr Gly  Gly Ala Thr 
    1310                 1315                 1320             


Ala Ala  Gly Thr Cys Thr Ala  Gly Ala Thr Gly Gly  Cys Ala Ala 
    1325                 1330                 1335             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1340                 1345                 1350             


Ala Gly  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Thr  Cys Thr Gly 
    1355                 1360                 1365             


Cys Ala  Thr Gly Ala Ala Gly  Cys Thr Cys Thr Gly  Cys Ala Thr 
    1370                 1375                 1380             


Thr Cys  Cys Cys Ala Cys Thr  Ala Thr Ala Cys Ala  Cys Ala Gly 
    1385                 1390                 1395             


Ala Ala  Gly Thr Cys Thr Cys  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1400                 1405                 1410             


Thr Cys  Thr Cys Cys Thr Gly  Gly Cys Ala Ala Gly  Ala Thr Cys 
    1415                 1420                 1425             


Gly Ala  Gly Gly Gly Cys Ala  Gly Ala Ala Thr Gly  Gly Ala Thr 
    1430                 1435                 1440             


Gly Ala  Cys Ala Thr Cys Cys  Ala Gly Ala Thr Gly  Ala Cys Ala 
    1445                 1450                 1455             


Cys Ala  Gly Ala Cys Ala Ala  Cys Cys Thr Cys Thr  Thr Cys Thr 
    1460                 1465                 1470             


Cys Thr  Gly Thr Cys Thr Gly  Cys Thr Thr Cys Thr  Cys Thr Gly 
    1475                 1480                 1485             


Gly Gly  Cys Gly Ala Thr Ala  Gly Ala Gly Thr Gly  Ala Cys Cys 
    1490                 1495                 1500             


Ala Thr  Cys Ala Gly Cys Thr  Gly Cys Ala Gly Ala  Gly Cys Thr 
    1505                 1510                 1515             


Thr Cys  Thr Cys Ala Gly Gly  Ala Cys Ala Thr Cys  Ala Gly Cys 
    1520                 1525                 1530             


Ala Ala  Gly Thr Ala Thr Cys  Thr Gly Ala Ala Cys  Thr Gly Gly 
    1535                 1540                 1545             


Thr Ala  Thr Cys Ala Gly Cys  Ala Gly Ala Ala Gly  Cys Cys Thr 
    1550                 1555                 1560             


Gly Ala  Thr Gly Gly Cys Ala  Cys Cys Gly Thr Gly  Ala Ala Gly 
    1565                 1570                 1575             


Cys Thr  Gly Cys Thr Gly Ala  Thr Cys Thr Ala Cys  Cys Ala Cys 
    1580                 1585                 1590             


Ala Cys  Cys Thr Cys Cys Ala  Gly Ala Thr Thr Gly  Cys Ala Thr 
    1595                 1600                 1605             


Thr Cys  Thr Gly Gly Ala Gly  Thr Thr Cys Cys Thr  Thr Cys Cys 
    1610                 1615                 1620             


Ala Gly  Ala Thr Thr Thr Thr  Cys Thr Gly Gly Cys  Thr Cys Thr 
    1625                 1630                 1635             


Gly Gly  Cys Thr Cys Thr Gly  Gly Cys Ala Cys Cys  Gly Ala Cys 
    1640                 1645                 1650             


Thr Ala  Thr Thr Cys Thr Cys  Thr Gly Ala Cys Cys  Ala Thr Cys 
    1655                 1660                 1665             


Ala Gly  Cys Ala Ala Thr Cys  Thr Gly Gly Ala Ala  Cys Ala Gly 
    1670                 1675                 1680             


Gly Ala  Gly Gly Ala Cys Ala  Thr Cys Gly Cys Thr  Ala Cys Cys 
    1685                 1690                 1695             


Thr Ala  Cys Thr Thr Thr Thr  Gly Cys Cys Ala Gly  Cys Ala Gly 
    1700                 1705                 1710             


Gly Gly  Cys Ala Ala Cys Ala  Cys Ala Cys Thr Gly  Cys Cys Thr 
    1715                 1720                 1725             


Thr Ala  Cys Ala Cys Ala Thr  Thr Thr Gly Gly Ala  Gly Gly Ala 
    1730                 1735                 1740             


Gly Gly  Ala Ala Cys Ala Ala  Ala Gly Cys Thr Gly  Gly Ala Gly 
    1745                 1750                 1755             


Ala Thr  Cys Ala Cys Ala Gly  Gly Ala Gly Gly Ala  Gly Gly Ala 
    1760                 1765                 1770             


Thr Cys  Thr Gly Gly Ala Gly  Gly Ala Gly Gly Ala  Thr Cys Thr 
    1775                 1780                 1785             


Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Gly Ala Ala 
    1790                 1795                 1800             


Gly Thr  Thr Ala Ala Ala Cys  Thr Gly Cys Ala Gly  Gly Ala Ala 
    1805                 1810                 1815             


Thr Cys  Thr Gly Gly Ala Cys  Cys Ala Gly Gly Ala  Thr Thr Ala 
    1820                 1825                 1830             


Gly Thr  Gly Gly Cys Cys Cys  Cys Ala Thr Cys Thr  Cys Ala Gly 
    1835                 1840                 1845             


Thr Cys  Thr Cys Thr Gly Thr  Cys Thr Gly Thr Gly  Ala Cys Cys 
    1850                 1855                 1860             


Thr Gly  Thr Ala Cys Cys Gly  Thr Thr Thr Cys Thr  Gly Gly Ala 
    1865                 1870                 1875             


Gly Thr  Thr Thr Cys Thr Thr  Thr Gly Cys Cys Thr  Gly Ala Thr 
    1880                 1885                 1890             


Thr Ala  Cys Gly Gly Ala Gly  Thr Gly Thr Cys Cys  Thr Gly Gly 
    1895                 1900                 1905             


Ala Thr  Cys Ala Gly Ala Cys  Ala Gly Cys Cys Cys  Cys Cys Thr 
    1910                 1915                 1920             


Ala Gly  Ala Ala Ala Gly Gly  Gly Ala Cys Thr Gly  Gly Ala Ala 
    1925                 1930                 1935             


Thr Gly  Gly Thr Thr Ala Gly  Gly Ala Gly Thr Gly  Ala Thr Thr 
    1940                 1945                 1950             


Thr Gly  Gly Gly Gly Ala Thr  Cys Thr Gly Ala Gly  Ala Cys Cys 
    1955                 1960                 1965             


Ala Cys  Cys Thr Ala Cys Thr  Ala Cys Ala Ala Cys  Thr Cys Thr 
    1970                 1975                 1980             


Gly Cys  Cys Cys Thr Gly Ala  Ala Gly Ala Gly Cys  Ala Gly Ala 
    1985                 1990                 1995             


Cys Thr  Gly Ala Cys Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    2000                 2005                 2010             


Gly Ala  Cys Ala Ala Cys Ala  Gly Cys Ala Ala Gly  Thr Cys Thr 
    2015                 2020                 2025             


Cys Ala  Gly Gly Thr Gly Thr  Thr Cys Cys Thr Gly  Ala Ala Gly 
    2030                 2035                 2040             


Ala Thr  Gly Ala Ala Cys Thr  Cys Cys Cys Thr Gly  Cys Ala Gly 
    2045                 2050                 2055             


Ala Cys  Cys Gly Ala Cys Gly  Ala Thr Ala Cys Cys  Gly Cys Cys 
    2060                 2065                 2070             


Ala Thr  Cys Thr Ala Cys Thr  Ala Cys Thr Gly Thr  Gly Cys Thr 
    2075                 2080                 2085             


Ala Ala  Gly Cys Ala Cys Thr  Ala Cys Thr Ala Cys  Thr Ala Thr 
    2090                 2095                 2100             


Gly Gly  Cys Gly Gly Cys Thr  Cys Thr Thr Ala Thr  Gly Cys Cys 
    2105                 2110                 2115             


Ala Thr  Gly Gly Ala Cys Thr  Ala Thr Thr Gly Gly  Gly Gly Ala 
    2120                 2125                 2130             


Cys Ala  Gly Gly Gly Cys Ala  Cys Cys Thr Cys Thr  Gly Thr Gly 
    2135                 2140                 2145             


Ala Cys  Ala Gly Thr Gly Thr  Cys Thr Thr Cys Thr  Thr Ala Ala 
    2150                 2155                 2160             


<210>  87
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  87

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Ala Gln Phe Ser Val Leu 
145                 150                 155                 160 


Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu 
                165                 170                 175     


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys 
            180                 185                 190         


Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly 
        195                 200                 205             


Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser 
    210                 215                 220                 


Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His 
225                 230                 235                 240 


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
                245                 250                 255     


Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met 
            500                 505                 510         


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser 
545                 550                 555                 560 


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            580                 585                 590         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
        595                 600                 605             


Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
625                 630                 635                 640 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                645                 650                 655     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            660                 665                 670         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        675                 680                 685             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    690                 695                 700                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
705                 710                 715                 720 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745         


<210>  88
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  88

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Ala Gln Phe Ser Val Leu 
145                 150                 155                 160 


Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu 
                165                 170                 175     


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys 
            180                 185                 190         


Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly 
        195                 200                 205             


Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser 
    210                 215                 220                 


Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His 
225                 230                 235                 240 


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
                245                 250                 255     


Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                405                 410                 415     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met 
            500                 505                 510         


Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
        515                 520                 525             


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys 
    530                 535                 540                 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
545                 550                 555                 560 


Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser 
                565                 570                 575     


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
            580                 585                 590         


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
        595                 600                 605             


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
625                 630                 635                 640 


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
                645                 650                 655     


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
            660                 665                 670         


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
        675                 680                 685             


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
    690                 695                 700                 


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
705                 710                 715                 720 


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
                725                 730                 735     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745                 750         


<210>  89
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  89

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro 
145                 150                 155                 160 


Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe 
                165                 170                 175     


Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser 
            180                 185                 190         


Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp 
        195                 200                 205             


Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly 
    210                 215                 220                 


Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser 
225                 230                 235                 240 


Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu 
                245                 250                 255     


Lys Ala Leu Val Glu Leu Lys Val Ala Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn 
    370                 375                 380                 


Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly 
                485                 490                 495     


Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            500                 505                 510         


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        515                 520                 525             


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    530                 535                 540                 


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
545                 550                 555                 560 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                565                 570                 575     


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            580                 585                 590         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
    610                 615                 620                 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
625                 630                 635                 640 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
                645                 650                 655     


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
            660                 665                 670         


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
        675                 680                 685             


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
    690                 695                 700                 


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
705                 710                 715                 720 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
                725                 730                 735     


Ser Ser 
        


<210>  90
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  90

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro 
145                 150                 155                 160 


Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe 
                165                 170                 175     


Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser 
            180                 185                 190         


Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp 
        195                 200                 205             


Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly 
    210                 215                 220                 


Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser 
225                 230                 235                 240 


Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu 
                245                 250                 255     


Lys Ala Leu Val Glu Leu Lys Val Ala Glu Pro Lys Ser Cys Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser 
            500                 505                 510         


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        515                 520                 525             


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    530                 535                 540                 


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
545                 550                 555                 560 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                565                 570                 575     


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            580                 585                 590         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        595                 600                 605             


Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    610                 615                 620                 


Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu 
625                 630                 635                 640 


Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
                645                 650                 655     


Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val 
            660                 665                 670         


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg 
        675                 680                 685             


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
    690                 695                 700                 


Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His 
705                 710                 715                 720 


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                725                 730                 735     


Ser Val Thr Val Ser Ser 
            740         


<210>  91
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  91

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro 
145                 150                 155                 160 


Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe 
                165                 170                 175     


Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser 
            180                 185                 190         


Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp 
        195                 200                 205             


Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly 
    210                 215                 220                 


Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser 
225                 230                 235                 240 


Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu 
                245                 250                 255     


Lys Ala Leu Val Glu Leu Lys Val Ala Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro 
    370                 375                 380                 


Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met 
            500                 505                 510         


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
    530                 535                 540                 


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser 
545                 550                 555                 560 


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                565                 570                 575     


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            580                 585                 590         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
        595                 600                 605             


Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
625                 630                 635                 640 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                645                 650                 655     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            660                 665                 670         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        675                 680                 685             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    690                 695                 700                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
705                 710                 715                 720 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                725                 730                 735     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745         


<210>  92
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  92

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly 
145                 150                 155                 160 


Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro 
                165                 170                 175     


Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp 
            180                 185                 190         


Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys 
        195                 200                 205             


Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile 
    210                 215                 220                 


Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn 
225                 230                 235                 240 


Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly 
                245                 250                 255     


Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
305                 310                 315                 320 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
                485                 490                 495     


Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser 
            500                 505                 510         


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        515                 520                 525             


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    530                 535                 540                 


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
545                 550                 555                 560 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                565                 570                 575     


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            580                 585                 590         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        595                 600                 605             


Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    610                 615                 620                 


Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu 
625                 630                 635                 640 


Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
                645                 650                 655     


Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val 
            660                 665                 670         


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg 
        675                 680                 685             


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
    690                 695                 700                 


Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His 
705                 710                 715                 720 


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                725                 730                 735     


Ser Val Thr Val Ser Ser 
            740         


<210>  93
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  93

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly 
145                 150                 155                 160 


Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro 
                165                 170                 175     


Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp 
            180                 185                 190         


Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys 
        195                 200                 205             


Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile 
    210                 215                 220                 


Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn 
225                 230                 235                 240 


Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly 
                245                 250                 255     


Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met Thr 
            500                 505                 510         


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
        515                 520                 525             


Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln 
    530                 535                 540                 


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg 
545                 550                 555                 560 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                565                 570                 575     


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
            580                 585                 590         


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly 
        595                 600                 605             


Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
625                 630                 635                 640 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                645                 650                 655     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            660                 665                 670         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        675                 680                 685             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    690                 695                 700                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
705                 710                 715                 720 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                725                 730                 735     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745     


<210>  94
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  94

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly 
145                 150                 155                 160 


Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro 
                165                 170                 175     


Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp 
            180                 185                 190         


Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys 
        195                 200                 205             


Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile 
    210                 215                 220                 


Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn 
225                 230                 235                 240 


Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly 
                245                 250                 255     


Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser 
    370                 375                 380                 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp 
            500                 505                 510         


Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
        515                 520                 525             


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
    530                 535                 540                 


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
545                 550                 555                 560 


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
                565                 570                 575     


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
            580                 585                 590         


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
        595                 600                 605             


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
625                 630                 635                 640 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                645                 650                 655     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            660                 665                 670         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        675                 680                 685             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    690                 695                 700                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
705                 710                 715                 720 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                725                 730                 735     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745                 750     


<210>  95
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  95

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe 
145                 150                 155                 160 


Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp 
                165                 170                 175     


Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met 
            180                 185                 190         


Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr 
        195                 200                 205             


Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly 
    210                 215                 220                 


Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu 
225                 230                 235                 240 


Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr 
                245                 250                 255     


Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val 
            260                 265                 270         


Ala Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser 
    370                 375                 380                 


Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met Thr 
            500                 505                 510         


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
        515                 520                 525             


Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln 
    530                 535                 540                 


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg 
545                 550                 555                 560 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                565                 570                 575     


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
            580                 585                 590         


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly 
        595                 600                 605             


Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
625                 630                 635                 640 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                645                 650                 655     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            660                 665                 670         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        675                 680                 685             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    690                 695                 700                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
705                 710                 715                 720 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                725                 730                 735     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745     


<210>  96
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  96

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe 
145                 150                 155                 160 


Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp 
                165                 170                 175     


Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met 
            180                 185                 190         


Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr 
        195                 200                 205             


Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly 
    210                 215                 220                 


Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu 
225                 230                 235                 240 


Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr 
                245                 250                 255     


Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val 
            260                 265                 270         


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg Met Asp Asp 
            500                 505                 510         


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        515                 520                 525             


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    530                 535                 540                 


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
545                 550                 555                 560 


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                565                 570                 575     


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            580                 585                 590         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        595                 600                 605             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
625                 630                 635                 640 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                645                 650                 655     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            660                 665                 670         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        675                 680                 685             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    690                 695                 700                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
705                 710                 715                 720 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                725                 730                 735     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745                 750 


<210>  97
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  97

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Gln Phe 
145                 150                 155                 160 


Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp 
                165                 170                 175     


Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met 
            180                 185                 190         


Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr 
        195                 200                 205             


Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly 
    210                 215                 220                 


Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu 
225                 230                 235                 240 


Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr 
                245                 250                 255     


Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val 
            260                 265                 270         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
    290                 295                 300                 


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
305                 310                 315                 320 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                325                 330                 335     


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            340                 345                 350         


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
        355                 360                 365             


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
    370                 375                 380                 


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
385                 390                 395                 400 


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                405                 410                 415     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu 
            500                 505                 510         


Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
        515                 520                 525             


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
    530                 535                 540                 


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
545                 550                 555                 560 


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
            580                 585                 590         


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
        595                 600                 605             


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln 
625                 630                 635                 640 


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
                645                 650                 655     


Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
            660                 665                 670         


Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly 
        675                 680                 685             


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
    690                 695                 700                 


Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
705                 710                 715                 720 


Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
                725                 730                 735     


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            740                 745                 750         


Val Ser Ser 
        755 


<210>  98
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  98

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly 
145                 150                 155                 160 


Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu 
                165                 170                 175     


Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser 
            180                 185                 190         


Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu 
        195                 200                 205             


Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp 
    210                 215                 220                 


Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala 
225                 230                 235                 240 


Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr 
                245                 250                 255     


Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
305                 310                 315                 320 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu 
                485                 490                 495     


Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            500                 505                 510         


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        515                 520                 525             


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    530                 535                 540                 


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
545                 550                 555                 560 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                565                 570                 575     


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            580                 585                 590         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln 
    610                 615                 620                 


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
625                 630                 635                 640 


Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
                645                 650                 655     


Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly 
            660                 665                 670         


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
        675                 680                 685             


Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
    690                 695                 700                 


Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
705                 710                 715                 720 


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
                725                 730                 735     


Val Ser Ser 
            


<210>  99
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  99

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly 
145                 150                 155                 160 


Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu 
                165                 170                 175     


Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser 
            180                 185                 190         


Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu 
        195                 200                 205             


Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp 
    210                 215                 220                 


Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala 
225                 230                 235                 240 


Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr 
                245                 250                 255     


Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ser Lys Tyr Gly Pro Pro 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
305                 310                 315                 320 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu 
                485                 490                 495     


Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            500                 505                 510         


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        515                 520                 525             


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    530                 535                 540                 


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
545                 550                 555                 560 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                565                 570                 575     


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            580                 585                 590         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln 
    610                 615                 620                 


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
625                 630                 635                 640 


Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
                645                 650                 655     


Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly 
            660                 665                 670         


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
        675                 680                 685             


Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
    690                 695                 700                 


Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
705                 710                 715                 720 


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
                725                 730                 735     


Val Ser Ser 
            


<210>  100
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  100

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ala Gln Phe Ser Val Leu Gly Pro Ser Gly 
145                 150                 155                 160 


Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu 
                165                 170                 175     


Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser 
            180                 185                 190         


Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu 
        195                 200                 205             


Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp 
    210                 215                 220                 


Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala 
225                 230                 235                 240 


Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr 
                245                 250                 255     


Glu Lys Ala Leu Val Glu Leu Lys Val Ala Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu 
    370                 375                 380                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Asp Ile Gln 
            500                 505                 510         


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        515                 520                 525             


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    530                 535                 540                 


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
545                 550                 555                 560 


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                565                 570                 575     


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            580                 585                 590         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        595                 600                 605             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
625                 630                 635                 640 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
                645                 650                 655     


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
            660                 665                 670         


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
        675                 680                 685             


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
    690                 695                 700                 


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
705                 710                 715                 720 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
                725                 730                 735     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745             


<210>  101
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  101

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val 
                165                 170                 175     


Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala 
            180                 185                 190         


Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val 
        195                 200                 205             


Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
    210                 215                 220                 


Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr 
                245                 250                 255     


Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu 
            260                 265                 270         


Leu Lys Val Ala Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly 
    370                 375                 380                 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Leu Gly Lys Ile Glu Gly Arg Met Asp Asp Ile 
            500                 505                 510         


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
        515                 520                 525             


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
    530                 535                 540                 


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His 
545                 550                 555                 560 


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                565                 570                 575     


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
            580                 585                 590         


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
625                 630                 635                 640 


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                645                 650                 655     


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            660                 665                 670         


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        675                 680                 685             


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    690                 695                 700                 


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
705                 710                 715                 720 


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                725                 730                 735     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            740                 745                 


<210>  102
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  102

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val 
                165                 170                 175     


Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala 
            180                 185                 190         


Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val 
        195                 200                 205             


Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
    210                 215                 220                 


Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr 
                245                 250                 255     


Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu 
            260                 265                 270         


Leu Lys Val Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Glu Gly Arg 
            500                 505                 510         


Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
        515                 520                 525             


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
    530                 535                 540                 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
            580                 585                 590         


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
        595                 600                 605             


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
625                 630                 635                 640 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                645                 650                 655     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            660                 665                 670         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        675                 680                 685             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    690                 695                 700                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
705                 710                 715                 720 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                725                 730                 735     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            740                 745                 750         


Ser 
    


<210>  103
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  103

Cys Cys Gly Cys Cys Ala Cys Cys Met Glu Phe Gly Leu Ser Trp Val 
1               5                   10                  15      


Phe Leu Val Ala Ile Ile Lys Gly Val Gln Cys Gln Phe Ile Val Val 
            20                  25                  30          


Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr Leu 
        35                  40                  45              


Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val Arg 
    50                  55                  60                  


Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly 
65                  70                  75                  80  


Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr Thr 
                85                  90                  95      


Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile His 
            100                 105                 110         


Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln Glu 
        115                 120                 125             


Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val 
                165                 170                 175     


Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala 
            180                 185                 190         


Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val 
        195                 200                 205             


Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
    210                 215                 220                 


Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr 
                245                 250                 255     


Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu 
            260                 265                 270         


Leu Lys Val Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                325                 330                 335     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            500                 505                 510         


Lys Ile Glu Gly Arg Met Asp Asp Ile Gln Met Thr Gln Thr Thr Ser 
        515                 520                 525             


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
    530                 535                 540                 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
545                 550                 555                 560 


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
                565                 570                 575     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
            580                 585                 590         


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
        595                 600                 605             


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    610                 615                 620                 


Ile Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu 
                645                 650                 655     


Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
            660                 665                 670         


Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val 
        675                 680                 685             


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg 
    690                 695                 700                 


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
705                 710                 715                 720 


Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His 
                725                 730                 735     


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            740                 745                 750         


Ser Val Thr Val Ser Ser 
        755             


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  106

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  107

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  108

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  109

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  110
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  111
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser 
                165                 170                 175     


Ser Gly Ser Gly Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly 
    210                 215                 220                 


Tyr Arg Tyr Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  112
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  112

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln 
    210                 215                 220                 


Val Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  113
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  113

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Glu 
465                 470                 475                 480 


Gly Gly Glu Asp Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Phe 
                485                 490                 495     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            500                 505                 510         


Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        515                 520                 525             


Ala Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
    530                 535                 540                 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
545                 550                 555                 560 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Glu Tyr Phe Cys Gln Gln 
                565                 570                 575     


Tyr Asn Asn Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            580                 585                 590         


Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    610                 615                 620                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
625                 630                 635                 640 


Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                645                 650                 655     


Trp Val Ala Tyr Ile Ser Ser Gly Ser Gly Thr Ile Tyr Tyr Ala Asp 
            660                 665                 670         


Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
        675                 680                 685             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    690                 695                 700                 


Tyr Cys Ala Arg His Gly Tyr Arg Tyr Glu Gly Phe Asp Tyr Trp Gly 
705                 710                 715                 720 


Gln Gly Thr Thr Val Thr Val Ser Ser 
                725                 


<210>  114
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  114

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Asp Ile Gln 
                485                 490                 495     


Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val 
            500                 505                 510         


Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp 
        515                 520                 525             


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile Tyr Ser Ala 
    530                 535                 540                 


Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
545                 550                 555                 560 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                565                 570                 575     


Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe Thr Phe Gly 
            580                 585                 590         


Gln Gly Thr Lys Leu Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    610                 615                 620                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
625                 630                 635                 640 


Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met His Trp Val Arg Gln 
                645                 650                 655     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser 
            660                 665                 670         


Gly Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser 
        675                 680                 685             


Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    690                 695                 700                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly Tyr Arg Tyr 
705                 710                 715                 720 


Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                725                 730                 735     


<210>  115
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  115

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Glu 
465                 470                 475                 480 


Gly Gly Glu Asp Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                485                 490                 495     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            500                 505                 510         


Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
        515                 520                 525             


Lys Gly Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr 
    530                 535                 540                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
545                 550                 555                 560 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                565                 570                 575     


Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp 
            580                 585                 590         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    610                 615                 620                 


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
625                 630                 635                 640 


Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln 
                645                 650                 655     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ile Gly Ala Ser Thr Arg 
            660                 665                 670         


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        675                 680                 685             


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    690                 695                 700                 


Tyr Cys Gln Gln Gly Gln Val Ile Pro Pro Thr Phe Gly Gln Gly Thr 
705                 710                 715                 720 


Lys Val Glu Ile Lys 
                725 


<210>  116
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  116

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Glu Val Gln 
                485                 490                 495     


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
    530                 535                 540                 


Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
545                 550                 555                 560 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                565                 570                 575     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp 
            580                 585                 590         


Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
625                 630                 635                 640 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
                645                 650                 655     


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
            660                 665                 670         


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
        675                 680                 685             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
    690                 695                 700                 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
705                 710                 715                 720 


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                725                 730         


<210>  117
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  117

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Glu 
465                 470                 475                 480 


Gly Gly Glu Asp Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
                485                 490                 495     


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
            500                 505                 510         


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly 
        515                 520                 525             


Gln Gly Leu Glu Trp Met Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
    530                 535                 540                 


Ser Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys 
545                 550                 555                 560 


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
                565                 570                 575     


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp 
            580                 585                 590         


Tyr Phe Asn Val Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Gly 
        595                 600                 605             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
625                 630                 635                 640 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val 
                645                 650                 655     


Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro 
            660                 665                 670         


Leu Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
        675                 680                 685             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
    690                 695                 700                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
705                 710                 715                 720 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                725                 730             


<210>  118
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  118

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Gln Val Gln 
                485                 490                 495     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            500                 505                 510         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Ile 
    530                 535                 540                 


Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Gln Gly Arg 
545                 550                 555                 560 


Val Thr Ile Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu Leu 
                565                 570                 575     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
            580                 585                 590         


Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr 
        595                 600                 605             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln 
625                 630                 635                 640 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                645                 650                 655     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys 
            660                 665                 670         


Pro Gly Lys Ser Pro Lys Pro Leu Ile Tyr Ala Thr Ser Asn Leu Ala 
        675                 680                 685             


Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    690                 695                 700                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
705                 710                 715                 720 


Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                725                 730                 735     


Val Glu Ile Lys 
            740 


<210>  119
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  119

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ile Val Val Gly Pro Thr Asp Pro Ile Leu Ala 
            20                  25                  30          


Thr Val Gly Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys 
        35                  40                  45              


Asn Ala Glu Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro 
    50                  55                  60                  


Ala Val Phe Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met 
65                  70                  75                  80  


Glu Glu Tyr Arg Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg 
                85                  90                  95      


Gly Ser Val Ala Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly 
            100                 105                 110         


Thr Tyr Arg Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile 
        115                 120                 125             


Leu His Leu Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met 
    130                 135                 140                 


Arg Gly His Glu Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly 
145                 150                 155                 160 


Trp Tyr Pro Lys Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val 
                165                 170                 175     


Ala Pro Ala Leu Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe 
            180                 185                 190         


Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met 
        195                 200                 205             


Ser Cys Ser Ile Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val 
    210                 215                 220                 


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Arg Lys Gly Gly Lys Arg Gly Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Glu 
465                 470                 475                 480 


Gly Gly Glu Asp Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Asp 
                485                 490                 495     


Leu Ala Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            500                 505                 510         


Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
        515                 520                 525             


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Pro Asp Gly Gly Gln Lys 
    530                 535                 540                 


Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
545                 550                 555                 560 


Pro Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                565                 570                 575     


Thr Ala Ile Tyr Tyr Cys Val Arg His Phe Asn Ala Trp Asp Tyr Trp 
            580                 585                 590         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    610                 615                 620                 


Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly Gly Arg Val Thr Ile 
625                 630                 635                 640 


Thr Cys Gln Ala Ser Gln Gly Ile Ser Gln Phe Leu Asn Trp Phe Gln 
                645                 650                 655     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Asp Ala Ser Asn 
            660                 665                 670         


Leu Glu Pro Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        675                 680                 685             


Asp Phe Thr Phe Thr Ile Thr Asn Leu Gln Pro Glu Asp Ile Ala Thr 
    690                 695                 700                 


Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Leu Thr Phe Gly Gly Gly 
705                 710                 715                 720 


Thr Lys Val Glu Ile Lys 
                725     


<210>  120
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  120

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Phe Ser Val Leu Gly Pro Ser Gly Pro Ile Leu Ala 
            20                  25                  30          


Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
        35                  40                  45              


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
    50                  55                  60                  


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
65                  70                  75                  80  


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
                85                  90                  95      


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
            100                 105                 110         


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
        115                 120                 125             


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Val Asp Val 
    130                 135                 140                 


Lys Gly Tyr Lys Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
145                 150                 155                 160 


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn 
                165                 170                 175     


Ile Pro Thr Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
            180                 185                 190         


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Glu Gly Val 
        195                 200                 205             


Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
    210                 215                 220                 


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala 
225                 230                 235                 240 


Ala Leu Ala Gly Gly Ser Gly Ser Asp Glu Gly Gly Glu Asp Gly Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Ser Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Asn Ala Thr Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Arg Lys Gly Gly Lys Arg Gly Ser Gly Ser Gln Val Gln 
                485                 490                 495     


Leu Val Gln Ser Gly Gly Asp Leu Ala Gln Pro Gly Arg Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
    530                 535                 540                 


Trp Pro Asp Gly Gly Gln Lys Tyr Tyr Gly Asp Ser Val Lys Gly Arg 
545                 550                 555                 560 


Phe Thr Val Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr Leu Gln Met 
                565                 570                 575     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Val Arg His 
            580                 585                 590         


Phe Asn Ala Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        595                 600                 605             


Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr 
625                 630                 635                 640 


Val Gly Gly Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser 
                645                 650                 655     


Gln Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            660                 665                 670         


Leu Ile Ser Asp Ala Ser Asn Leu Glu Pro Gly Val Pro Ser Arg Phe 
        675                 680                 685             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Thr Asn Leu 
    690                 695                 700                 


Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu 
705                 710                 715                 720 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                725                 730             


