                         SEQUENCE LISTING

<110>  ALECTOR LLC
 
<120>  ANTI-TMEM106B ANTIBODIES AND METHODS OF USE THEREOF

<130>  4503.014PC01

<150>  63/162,849
<151>  2021-03-18

<160>  267   

<170>  PatentIn version 3.5

<210>  1
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TMEM106B

<400>  1

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  2
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse TMEM106B

<400>  2

Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Asn Lys Glu Asp Gly 
1               5                   10                  15      


Tyr Asp Gly Val Thr Ser Thr Asp Asn Met Arg Asn Gly Leu Val Ser 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Glu Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Ala Glu Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Asn Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Leu Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Ala Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Ala Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  3
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus TMEM106B

<400>  3

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Arg Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ala Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr His Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-54 Antibody Variable Heavy Chain

<400>  4

Gln Val Gln Met Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asp Leu Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Gly Gly Ser Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Tyr Ser Ile Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-56 Antibody Variable Heavy Chain

<400>  5

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Lys Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Tyr Ala Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-59 Antibody Variable Heavy Chain

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asn Pro Ser Ser Gly Tyr Thr Lys Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-60 Antibody Variable Heavy Chain

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asn Thr Gln Tyr Ile Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Ile Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-61 Antibody Variable Heavy Chain

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Gly Ser Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-62 Antibody Variable Heavy Chain

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr Gln Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Thr Leu Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-63 Antibody Variable Heavy Chain

<400>  10

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Phe Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Asn Trp Asp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-64 ANTIBODY VARIABLE HEAVY CHAIN

<400>  11

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Phe Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Thr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-65 ANTIBODY VARIABLE HEAVY CHAIN

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Lys Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Pro Thr Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-66 ANTIBODY VARIABLE HEAVY CHAIN

<400>  13

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Val Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Glu Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-68 ANTIBODY VARIABLE HEAVY CHAIN

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Pro Gln Thr Ala Thr Thr Cys Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-69 ANTIBODY VARIABLE HEAVY CHAIN

<400>  15

Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Glu Ala Gly Pro Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-70 ANTIBODY VARIABLE HEAVY CHAIN

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Tyr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-71 ANTIBODY VARIABLE HEAVY CHAIN

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-72 ANTIBODY VARIABLE HEAVY CHAIN

<400>  18

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Lys Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-73 ANTIBODY VARIABLE HEAVY CHAIN

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Lys His Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr His Gly Ser Gly Pro Pro Phe Ala His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-74 ANTIBODY VARIABLE HEAVY CHAIN

<400>  20

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Asn Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Asp Tyr Glu Gly Tyr Thr Met Asp Tyr Gly Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-75 ANTIBODY VARIABLE HEAVY CHAIN

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-76 ANTIBODY VARIABLE HEAVY CHAIN

<400>  22

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Lys Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Trp Asp Asp Asp Lys Arg Tyr Asn Leu Phe 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Met Ile Thr Ser Val Asp Thr Thr Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Gly Arg Gln Arg Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-77 ANTIBODY VARIABLE HEAVY CHAIN

<400>  23

Gln Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Tyr Gly Ile Glu Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-78 ANTIBODY VARIABLE HEAVY CHAIN

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn His Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Ile Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-79 ANTIBODY VARIABLE HEAVY CHAIN

<400>  25

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Leu Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala His Ile Thr Pro His Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gln Phe Gly Arg Gly Asp Tyr Phe His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-80 ANTIBODY VARIABLE HEAVY CHAIN

<400>  26

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Glu Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Asn Trp Asp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Val Thr Val Ser Ser 
        115             


<210>  27
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-81 ANTIBODY VARIABLE HEAVY CHAIN

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Ile His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Ala Gly Gln Ile Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-82 ANTIBODY VARIABLE HEAVY CHAIN

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Ile Thr Asp Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Arg Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser Pro Phe Ile Thr Thr Val Val Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-83 ANTIBODY VARIABLE HEAVY CHAIN

<400>  29

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Asn Thr Lys Asn Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Asp Tyr Tyr Gly Thr Ser Tyr Pro Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-84 ANTIBODY VARIABLE HEAVY CHAIN

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Tyr Gly Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  31
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-85 ANTIBODY VARIABLE HEAVY CHAIN

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Ala Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Gly Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Ser Gly Asp Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Leu Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-86 ANTIBODY VARIABLE HEAVY CHAIN

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Arg Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Pro Tyr Asn Asp Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Tyr Tyr Ser Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-87 ANTIBODY VARIABLE HEAVY CHAIN

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gly Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Gly Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  34
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-88 ANTIBODY VARIABLE HEAVY CHAIN

<400>  34

Glu Ala Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Ser Gly Ala Thr Tyr Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Gln Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Tyr Gly His Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-89 ANTIBODY VARIABLE HEAVY CHAIN

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Ser Lys Tyr Val His Tyr Pro Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-90 ANTIBODY VARIABLE HEAVY CHAIN

<400>  36

Gln Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asn Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asn Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Ser Asp Tyr His Gly Gly Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-91 ANTIBODY VARIABLE HEAVY CHAIN

<400>  37

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asp Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Tyr Ser Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  38
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-92 ANTIBODY VARIABLE HEAVY CHAIN

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Pro Asn Asp Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Tyr Tyr Tyr Gly Ile Ser Tyr Glu Gly Gly Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-93 ANTIBODY VARIABLE HEAVY CHAIN

<400>  39

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Glu 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Pro Pro Lys Ile Phe Tyr Asp Tyr Leu Met Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  40
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-94 ANTIBODY VARIABLE HEAVY CHAIN

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Gly Thr Leu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Ser Leu Thr Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr His Gly Thr Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-54 ANTIBODY VARIABLE LIGHT CHAIN

<400>  41

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-56 ANTIBODY VARIABLE LIGHT CHAIN

<400>  42

Asp Ile Glu Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Gln Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-59 ANTIBODY VARIABLE LIGHT CHAIN

<400>  43

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Ser Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-60 VARIABLE LIGHT CHAIN

<400>  44

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-61 ANTIBODY VARIABLE LIGHT CHAIN

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Ser Asn Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Met 
            100                 105                 110         


Lys 
    


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-62 ANTIBODY VARIABLE LIGHT CHAIN

<400>  46

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ala Gly Ser Ser Pro Lys Pro Trp Ile His 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Arg Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Val Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  47
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-63 ANTIBODY VARIABLE LIGHT CHAIN

<400>  47

Asp Ile Val Met Thr Gln Ala Ser Pro Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Arg Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Gln Tyr Pro Phe Ser Phe Gly Ser Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-64 ANTIBODY VARIABLE LIGHT CHAIN

<400>  48

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Arg Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-65 ANTIBODY VARIABLE LIGHT CHAIN

<400>  49

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Ile Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Gly Gln Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Gly Ile Lys 
            100                 105         


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-66 ANTIBODY VARIABLE LIGHT CHAIN

<400>  50

Asp Val Val Val Thr Gln Thr Pro Pro Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asn Ser 
            20                  25                  30          


Tyr Gly Lys Thr Phe Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  51
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-68 ANTIBODY VARIABLE LIGHT CHAIN

<400>  51

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Val Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      


Leu Glu Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-69 ANTIBODY VARIABLE LIGHT CHAIN

<400>  52

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  53
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-70 ANTIBODY VARIABLE LIGHT CHAIN

<400>  53

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Asp Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Ala Ile Lys 
            100                 105                 110     


<210>  54
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-71 & TM-72 ANTIBODY VARIABLE LIGHT CHAIN

<400>  54

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Ile Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Arg Lys Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  55
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-73 ANTIBODY VARIABLE LIGHT CHAIN

<400>  55

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Ile Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Glu Thr Ser Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Trp Arg Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105     


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-74 ANTIBODY VARIABLE LIGHT CHAIN

<400>  56

Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Glu 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Lys Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-75 ANTIBODY VARIABLE LIGHT CHAIN

<400>  57

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Phe Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  58
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-76 ANTIBODY VARIABLE LIGHT CHAIN

<400>  58

Gln Ile Ile Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Leu Ser Ile Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ile Tyr Arg Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105 


<210>  59
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-77 ANTIBODY VARIABLE LIGHT CHAIN

<400>  59

Asp Val Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Met Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-78 ANTIBODY VARIABLE LIGHT CHAIN

<400>  60

Asp Ile Val Met Thr Gln Ala Thr Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  61
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-79 ANTIBODY VARIABLE LIGHT CHAIN

<400>  61

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Ser Ile Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys 
            100                 105                 110     


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-80 ANTIBODY VARIABLE LIGHT CHAIN

<400>  62

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly His Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  63
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-81 ANTIBODY VARIABLE LIGHT CHAIN

<400>  63

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Lys Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Phe Leu Val Tyr Phe Ala Phe Phe Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  64
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-82 ANTIBODY VARIABLE LIGHT CHAIN

<400>  64

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asn Thr 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu His Thr Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Pro Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  65
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-83 ANTIBODY VARIABLE LIGHT CHAIN

<400>  65

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-84 ANTIBODY VARIABLE LIGHT CHAIN

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Gly Trp Tyr His Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Leu Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-85 ANTIBODY VARIABLE LIGHT CHAIN

<400>  67

Asp Ile Ala Met Ser Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105         


<210>  68
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-86 ANTIBODY VARIABLE LIGHT CHAIN

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp His Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-87 ANTIBODY VARIABLE LIGHT CHAIN

<400>  69

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Arg Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-88 ANTIBODY VARIABLE LIGHT CHAIN

<400>  70

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Ser Asp Ile Asp Asp His 
            20                  25                  30          


Met Asn Trp Tyr Arg Gln Lys Pro Gly Glu Pro Pro Glu Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ala Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Ile Phe Thr Ile Glu Asn Ile Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-89 ANTIBODY VARIABLE LIGHT CHAIN

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-90 ANTIBODY VARIABLE LIGHT CHAIN

<400>  72

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Phe Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser His Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Asn 
                85                  90                  95      


Ser His Val Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-91 ANTIBODY VARIABLE LIGHT CHAIN

<400>  73

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Tyr Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  74
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-92 ANTIBODY VARIABLE LIGHT CHAIN

<400>  74

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-93 ANTIBODY VARIABLE LIGHT CHAIN

<400>  75

Asp Ile Val Met Thr Gln Ser His Lys Leu Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ser Ser Thr Arg Leu Pro Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Val Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  76
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM-94 ANTIBODY VARIABLE LIGHT CHAIN

<400>  76

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  77

Thr Tyr Asp Leu Asn 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  78

Ser Tyr Trp Met His 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  79

Ser Tyr Asp Ile Asn 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  80

Asn Tyr Trp Met Asn 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  81

Arg Tyr Trp Met His 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  82

Ser Phe Trp Met His 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  83

Ser Ser Trp Met His 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  84

Asn Tyr Ala Met Ser 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  85

Asp Asp Tyr Met His 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  86

Ser Tyr Gly Val His 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  87

Asn Tyr Trp Met His 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  88

Ser His Trp Met His 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  89

Ser Tyr Val Ile His 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  90

Ser Tyr Val Met His 
1               5   


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  91

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  92

Asp Tyr Glu Met His 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  93

Asn His Trp Met His 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  94

Asn Tyr Val Met His 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  95

Thr Phe Trp Met His 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  96

Asn Tyr Leu Ile Glu 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  97

Thr Tyr Trp Ile His 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  98

Thr Phe Pro Ile Glu 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  99

Gly Tyr Trp Met His 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  100

Asp Tyr Tyr Ile His 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  101

Asp Tyr Tyr Met Asn 
1               5   


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  102

Asp Tyr Tyr Ile Asn 
1               5   


<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  103

Ser Gly Tyr Tyr Trp Asp 
1               5       


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  104

Asp Tyr Thr Met Asp 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  105

Ser Tyr Gly Ile Ser 
1               5   


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H1

<400>  106

Asp Tyr Asn Met Asp 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  107

Trp Ile Tyr Pro Arg Gly Gly Ser Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  108

Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Lys Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  109

Tyr Val Asn Pro Ser Ser Gly Tyr Thr Lys Asn Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  110

Trp Ile Tyr Pro Arg Asp Gly Asn Thr Gln Tyr Ile Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  111

Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Lys Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  112

Asn Ile Asp Pro Ser Asp Ser Glu Thr Gln Tyr Asn Pro Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  113

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  114

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Asn Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  115

Glu Ile Asn Pro Lys Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  116

Thr Ile Gly Ser Val Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  117

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  118

Ile Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  119

Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  120

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  121

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  122

Phe Ile Asn Pro Asn Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  123

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  124

His Ile Phe Trp Asp Asp Asp Lys Arg Tyr Asn Leu Phe Leu Lys Ser 
1               5                   10                  15      


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  125

Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  126

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn His Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  127

His Ile Thr Pro His Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  128

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Glu Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  129

Asn Ile Asp Pro Ser Asp Ser Glu Ile His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  130

Val Ile Asn Pro Gly Ser Gly Ile Thr Asp Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  131

Asn Ile Asn Pro Ser Asn Gly Asn Thr Lys Asn Asn Glu Arg Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  132

Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  133

Arg Ile Asp Pro Tyr Ser Gly Asp Thr Arg Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  134

Val Ile Ser Pro Tyr Asn Asp Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  135

Val Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  136

Val Ile Asn Pro Tyr Ser Gly Ala Thr Tyr Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  137

Val Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  138

Trp Ile Tyr Pro Arg Asp Gly Asn Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  139

Tyr Ile Ser Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  140

His Ile Asn Pro Asn Asp Gly Gly Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  141

Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Glu Ser 
1               5                   10                  15      


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H2

<400>  142

Asp Ile Asn Pro Tyr Asn Gly Gly Thr Leu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  143

Tyr Ser Ile Tyr Ala Met Asp Tyr 
1               5               


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  144

Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  145

Trp Ile Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  146

Trp Gly Gly Ser Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  147

Leu Thr Thr Leu Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  148

Ser Ser Asn Trp Asp Asn Phe Asp Tyr 
1               5                   


<210>  149
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  149

Ser Arg Gly Gly Thr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
1               5                   10                  


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  150

Pro Thr Trp Phe Thr Tyr 
1               5       


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  151

Gln Glu Gly Ser Ser His Phe Asp Tyr 
1               5                   


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  152

Pro Gln Thr Ala Thr Thr Cys 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  153

Glu Ala Gly Pro Tyr Gly Met Asp Tyr 
1               5                   


<210>  154
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  154

Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr 
1               5                   10          


<210>  155
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  155

Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
1               5                   10                  


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  156

Asn Tyr His Gly Ser Gly Pro Pro Phe Ala His 
1               5                   10      


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  157

Pro Tyr Tyr Asp Tyr Glu Gly Tyr Thr Met Asp Tyr 
1               5                   10          


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  158

Gly Gly Trp Phe Pro Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  159

Met Gly Arg Gln Arg Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  160

Tyr Gly Ile Glu Gly Tyr 
1               5       


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  161

Ser Gly Gln Phe Gly Arg Gly Asp Tyr Phe His Tyr 
1               5                   10          


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  162

Ser Pro Ala Gly Gln Ile Leu Asp Tyr 
1               5                   


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  163

Ser Pro Phe Ile Thr Thr Val Val Ala Asp Tyr 
1               5                   10      


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  164

Gly Asp Tyr Tyr Gly Thr Ser Tyr Pro Phe 
1               5                   10  


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  165

Tyr Phe Tyr Gly Gly Met Asp Tyr 
1               5               


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  166

Tyr Gly Leu Gly His Ala Met Asp Tyr 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  167

Thr Tyr Tyr Ser Asn Tyr Phe Asp Tyr 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  168

Gly Asn Tyr Asp Trp Tyr Phe Asp Val 
1               5                   


<210>  169
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  169

Gly Gly Tyr Asp Tyr Gly His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  170

Asp Pro Tyr Ser Lys Tyr Val His Tyr Pro Met Asp Tyr 
1               5                   10              


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  171

Val Ser Asp Tyr His Gly Gly Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  172

Ala Val Tyr Ser Val Gly Phe Ala Tyr 
1               5                   


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  173

Trp Val Tyr Tyr Tyr Gly Ile Ser Tyr Glu Gly Gly Ala Met Asp Tyr 
1               5                   10                  15      


<210>  174
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  174

Asn Pro Pro Lys Ile Phe Tyr Asp Tyr Leu Met Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-H3

<400>  175

Val Gly Tyr His Gly Thr Pro Asp Tyr 
1               5                   


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  176

Arg Ser Ser Gln Ser Ile Val His Gly Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  177
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  177

Arg Ser Ser Lys Ser Leu Leu Gln Asn Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  178
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  178

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Ser Tyr 
1               5                   10                  15      


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  179

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    

<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  180

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  181
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  181

Arg Ser Ser Gln Ser Leu Leu His Val Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  182
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  182

Arg Ser Ser Lys Ser Leu Leu His Thr Asn Gly Asn Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  183
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  183

Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser 
1               5                   10      


<210>  184
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  184

Arg Ser Ser Gln Ser Leu Val Asn Ser Tyr Gly Lys Thr Phe Leu Ser 
1               5                   10                  15      


<210>  185
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  185

Ser Ser Ser Lys Ser Leu Leu His Ser Ser Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  186
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  186

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  187
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  187

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  188

Ser Ala Ser Ser Gly Ile Ser Tyr Ile Tyr 
1               5                   10  


<210>  189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  189

Lys Ala Ser Gln Asn Val Arg Ser Ala Val Ala 
1               5                   10      


<210>  190
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  190

Arg Ala Ser Gln Ser Val Asp Tyr Asn Gly Ile Ser Tyr Met His 
1               5                   10                  15  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  191

Ser Ala Ser Leu Ser Ile Ser Tyr Val His 
1               5                   10  


<210>  192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  192

Lys Ser Ser Gln Ser Leu Phe His Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  193
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  193

Arg Ser Ser Lys Ser Leu Leu His Val Asn Gly Asn Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  194
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  194

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Ser Ile Tyr Ile His 
1               5                   10                  15  


<210>  195
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  195

Arg Ser Ser Gln Ser Leu Leu His Val Asn Gly His Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  196

Lys Ser Ser Gln Ser Leu Leu Asn Ser Lys Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    

<210>  197
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  197

Arg Ser Ser Gln Ser Leu Ala Asn Thr Tyr Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  198
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  198

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Thr Tyr Leu His 
1               5                   10                  15      


<210>  199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  199

Arg Ala Ser Glu Asn Ile Tyr Ser Ser Leu Gly 
1               5                   10      


<210>  200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  200

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  201

Arg Ala Ser Arg Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  202

Ile Thr Ser Ser Asp Ile Asp Asp His Met Asn 
1               5                   10      


<210>  203
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  203

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  204
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  204

Arg Ser Ser Gln Ser Phe Val His Gly Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  205

Lys Ala Ser Gln Asn Val Tyr Thr Asn Val Ala 
1               5                   10      


<210>  206
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  206

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  207

Lys Ala Ser Gln Asp Val Gly Ser Ala Val Ala 
1               5                   10      


<210>  208
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L1

<400>  208

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  209

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  210

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  211

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  212

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  213

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  214

Gly Ile Ser Asn Arg Phe Ser 
1               5           


<210>  215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  215

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  216

Arg Lys Ser Asn Leu Ala Ser 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  217

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  218

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  219

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  220

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  221

Met Val Ser Lys Leu Glu Ser 
1               5           


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  222

Leu Thr Ser Asn Leu Glu Ser 
1               5           


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  223

Phe Ala Phe Phe Arg Glu Ser 
1               5           


<210>  224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  224

Gly Ile Ser Asn Arg Phe Ser 
1               5       


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  225

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  226

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  227

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  228

Glu Gly Asn Ala Leu Arg Pro 
1               5           


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  229

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  230

Lys Val Ser His Arg Phe Ser 
1               5           


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L2

<400>  231

Trp Ser Ser Thr Arg Leu Pro 
1               5           


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  232

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  233

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  234

Phe Gln Gly Ser His Leu Pro Tyr Thr 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  235

Gln Asn Asp Ser Asn Tyr Pro Phe Thr 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  236

Gln Gln Tyr His Ser Tyr Pro Pro Thr 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  237

Met Gln His Leu Gln Tyr Pro Phe Ser 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  238

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  239
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  239

Leu Gln Gly Gln Ser Tyr Pro Tyr Thr 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  240

Leu Gln Gly Thr His Pro Pro Leu Thr 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  241

Ala Gln Met Leu Glu Arg Pro Trp Thr 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  242

Ser Gln Asn Thr His Val Pro Leu Thr 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  243

Gln Gln Ser Lys Asp Val Pro Trp Thr 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  244

His Gln Trp Arg Ser Tyr Pro Pro Thr 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  245

Leu Gln His Trp Lys Tyr Pro Phe Thr 
1               5                   


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  246

Gln Gln Ser Ile Glu Asp Pro Trp Thr 
1               5                   


<210>  247
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  247

His Gln Trp Ser Ile Tyr Arg Thr 
1               5               


<210>  248
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  248

Leu Gln Val Thr His Phe Pro Leu Thr 
1               5                   


<210>  249
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  249

Gln His Ser Gly Glu Leu Pro Trp Thr 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  250

Met Gln His Leu Gln Tyr Pro Phe Thr 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  251

Gln Gln His Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  252

Leu Gln Gly Thr His Pro Pro Arg Thr 
1               5                   


<210>  253
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  253

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  254

Gln His Leu Trp Ser Val Pro Trp Thr 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  255

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  256

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  257
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  257

Gln Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   


<210>  258
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  258

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  259

Leu Gln Tyr Ala Ser Ser Pro Arg Thr 
1               5                   


<210>  260
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  260

Phe Gln Asn Ser His Val Pro His Thr 
1               5                   


<210>  261
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  261

Gln Gln His Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  262
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  262

Gln Gln Tyr Thr Ser Tyr Pro Leu Thr 
1               5                   


<210>  263
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTIBODY CDR-L3

<400>  263

Ser Gln Ser Thr His Val Tyr Thr 
1               5               


<210>  264
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region primer

<400>  264
agctgggaag gtgtgcaca                                                    19


<210>  265
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light constant region primer 

<400>  265
ccattttgtc gttcactgcc a                                                 21


<210>  266
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST FUSION HUMAN TMEM106B ECD (truncated)

<400>  266

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile 
            20                  25                  30          


Lys Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu 
        35                  40                  45              


Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg 
    50                  55                  60                  


Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr 
65                  70                  75                  80  


Ile Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr 
                85                  90                  95      


Ile Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala 
            100                 105                 110         


Glu Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val 
        115                 120                 125             


Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe 
    130                 135                 140                 


Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys 
145                 150                 155                 160 


His Lys Thr Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met 
                165                 170                 175     


Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu 
            180                 185                 190         


Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile 
        195                 200                 205             


Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro 
    210                 215                 220                 


Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
225                 230                 235                 240 


Ser Asp Pro Arg Glu Phe Ile Val Thr Asp Asp Ile Glu Gly Arg Met 
                245                 250                 255     


Asp Pro Asp Val Lys Tyr Ile Gly Val Lys Ser Ala Tyr Val Ser Tyr 
            260                 265                 270         


Asp Val Gln Lys Arg Thr Ile Tyr Leu Asn Ile Thr Asn Thr Leu Asn 
        275                 280                 285             


Ile Thr Asn Asn Asn Tyr Tyr Ser Val Glu Val Glu Asn Ile Thr Ala 
    290                 295                 300                 


Gln Val Gln Phe Ser Lys Thr Val Ile Gly Lys Ala Arg Leu Asn Asn 
305                 310                 315                 320 


Ile Thr Ile Ile Gly Pro Leu Asp Met Lys Gln Ile Asp Tyr Thr Val 
                325                 330                 335     


Pro Thr Val Ile Ala Glu Glu Met Ser Tyr Met 
            340                 345         


<210>  267
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST FUSION HUMAN TMEM106B ECD

<400>  267

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile 
            20                  25                  30          


Lys Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu 
        35                  40                  45              


Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg 
    50                  55                  60                  


Asn Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr 
65                  70                  75                  80  


Ile Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr 
                85                  90                  95      


Ile Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala 
            100                 105                 110         


Glu Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val 
        115                 120                 125             


Ser Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe 
    130                 135                 140                 


Leu Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys 
145                 150                 155                 160 


His Lys Thr Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met 
                165                 170                 175     


Leu Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu 
            180                 185                 190         


Asp Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile 
        195                 200                 205             


Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro 
    210                 215                 220                 


Leu Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
225                 230                 235                 240 


Ser Asp Pro Arg Glu Phe Ile Val Thr Asp Asp Ile Glu Gly Arg Met 
                245                 250                 255     


Asp Pro Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val Lys Ser Ala 
            260                 265                 270         


Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu Asn Ile Thr 
        275                 280                 285             


Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val Glu Val Glu 
    290                 295                 300                 


Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile Gly Lys Ala 
305                 310                 315                 320 


Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met Lys Gln Ile 
                325                 330                 335     


Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser Tyr Met Tyr 
            340                 345                 350         


Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile Val Leu Met 
        355                 360                 365             


Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser Glu Gln Ile 
    370                 375                 380                 


Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn Thr Thr Tyr 
385                 390                 395                 400 


Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro Gln Gln 
                405                 410                 415 


