                         SEQUENCE LISTING

<110>  TIBA BIO
 
<120>  ARTIFICIAL APLPHAVIRUS-DERIVED RNA REPLICON EXPRESSION SYSTEM

<130>  TIB-PT012WO

<150>  63/163,475
<151>  2021-03-19

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C01 nsP coding sequence DNA

<400>  1
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaagtacgc ctgcaacaac     6360

gagtactggg agacattcaa agagaacccc atccggctga ccgaggaaaa cgtggtcaac     6420

tacatcacca agctgaaggg ccccaaagcc gccgctctgt ttgccaagac acacaacctg     6480

aacatgctgc aggacatccc catggacaga ttcgtgatgg acctgaagcg ggacgtgaaa     6540

gtgacccctg gcaccaagca caccgaggaa cggcctaagg tgcaagtgat ccaggccgct     6600

gatcctctgg ccacagccta tctgtgtggc atccacagag aactcgtgcg gagactgaat     6660

gccgtgctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgctga tgattctgga agatctcgga     6840

gtggacgccg agctgctgac actgattgaa gccgcctttg gcgagatcag cagcatccat     6900

ctgcctacca agaccaagtt caagttcggc gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

acaggcagcc cttgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  2
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C02 nsP coding sequence DNA

<400>  2
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat atgccgtgga tggccctaca      480

agcctgtacc accaggccaa caagggcgtc agagtggcct actggatcgg cttcgacacc      540

acacctttca tgttcaagaa cctggctggc gcttacccca gctacagcac aaactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  3
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C03 nsP coding sequence DNA

<400>  3
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccctac     3660

aagtaccacc actaccagca gtgcgaggac cacgccatca agctgagcat gctgaccaag     3720

aaggcctgcc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat cggctacgac     3900

agaaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  4
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C04 nsP coding sequence DNA

<400>  4
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa cccctacaag ctgagcagca ccctgaccaa catctacacc     3960

ggcagcagac tgcacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacagcca cagaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  5
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C05 nsP coding sequence DNA

<400>  5
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagc gagaagctga gctgcattca ccctctggcc     1740

gagcaagtga tcgtgatcac acacagcggc cggaagggca gatatgccgt ggaaccttat     1800

cacggcaagg tggtggtgcc tgagggacac gctattccag tgcaggactt tcaggccctg     1860

agcgagtctg ccaccatcgt gtacaacgag cgcgagttcg tgaacagata cctgcaccac     1920

attgccacac acggcggagc cctgaacacc gacgaagagt actacaagac cgtgaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggat agcgtgctgc tgaacggctg caagcacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcctaagca gtgcggcttc     2460

ttcaacatga tgtgcctgaa ggtgcacttc aaccacgaga tctgcaccca ggtgttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  6
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C06 nsP coding sequence DNA

<400>  6
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc cagaaatatc ggcctgtgta gcagcgacgt gatggaaaga      660

tccagacggg gcatgagcat cctgcggaag aagtacctga agcctagcaa caacgtgctg      720

ttcagcgtgg gcagcaccat ctaccacgag aagagggacc tgctgcggag ctggcatctg      780

ccttccgtgt ttcacctgag aggcaagcag aactacacct gtagatgcga gacaatcgtg      840

tcctgcgacg gctacgtggt caagcggatc gccatttctc ctggcctgta cggcaagcct      900

tctggctatg ccgccaccat gcacagagaa ggctttctgt gttgcaaagt gaccgacaca      960

ctgaacggcg agcgggtgtc ctttcctgtg tgtacctatg tgcccgccac actgtgcgat     1020

cagatgacag gcattctggc caccgacgtg tcagccgacg atgcccagaa actgctcgtg     1080

ggcctgaacc agagaatcgt ggtcaacggc agaacccagc ggaacaccaa caccatgaag     1140

aactacctgc tgcctgtggt ggcccaggcc tttgccagat gggccaaaga gtacaaagag     1200

gatcaagagg acgagcggcc cctgggcctg agagatagac aactggtcat gggctgctgc     1260

tgggccttca gaaggcacaa gatcaccagc atctacaagc ggcccgacac acagaccatc     1320

atcaaagtga acagcgactt ccacagcttc gtgctgcctc ggatcggcag caacacactg     1380

gaaatcggcc tgcggacccg gatcagaaag atgctggaag aacacaaaga gccctctcca     1440

ctgatcaccg ccgaggatgt gcaagaggcc aaatgtgccg ccgacgaggc taaagaagtg     1500

cgcgaagccg aggaactgag agccgcactt cctcctctgg ccgccgatgt tgaagaaccc     1560

actctggaag ccgacgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  7
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C07 nsP coding sequence DNA

<400>  7
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aagagcatca gcagacggtg caccaagagc gtgaccagcg tggtgtctac cctgttctac     2580

gacaagaaga tgcggacgac aaaccccaaa gagacaaaga tcgtcatcga caccaccggc     2640

agcaccaagc ctaagcagga cgatctgatc ctgacctgct tcagaggctg ggtcaagcag     2700

ctgcagatcg actacaaggg caacgagatc atgaccgccg ctgcctctca gggcctgaca     2760

agaaaaggcg tgtacgccgt gcggtacaaa gtgaacgaga accctctgta cgcccctacc     2820

agcgagcatg tgaatgtgct gctgacccgg accgaggacc ggatcgtttg gaaaacactg     2880

gccggcgatc cctggatcaa gaccctgaca gccaagtatc ccggcaactt caccgccacc     2940

atcgaggaat ggcaggccga gcacgatgcc atcatgcggc acatcctgga aagacccgat     3000

cctaccgacg tgttccagaa caaggccaac gtgtgctggg ccaaagctct ggtgcctgtg     3060

ctgaaaaccg ccggcatcga tatgaccacc gagcagtgga acaccgtgga ctacttcgag     3120

acagacaagg cccacagcgc cgagatcgtg ctgaatcagc tgtgcgtgcg gttcttcggc     3180

ctggatctgg atagcggcct gttctctgct cctaccgtgc ctctgagcat ccggaacaac     3240

cactgggaca acagcccctc tcctaatatg tacggcctga acaaagaagt cgtgcggcag     3300

ctgagcagaa gatacccaca gctgcctaga gccgtggcca caggcagagt gtacgacatg     3360

aataccggca cactgcggaa ctacgacccc agaatcaatc tggtgcccgt gaacagaagg     3420

ctgccccacg ctctggttct gcaccacaat gagcaccctc agagcgactt cagcagcttc     3480

gtgtccaagc tgaagggcag aaccgtgctg gttgtgggcg agaagctgtc tgtgcctggc     3540

aagatggtgg actggctgag cgatagaccc gaggccacct ttagagccag actggacctt     3600

ggaatccctg gcgacgtgcc caaatacgac atcatcttcg tgaacgtgcg gacgccctac     3660

aagtaccacc actaccagca gtgcgaggac cacgccatca agctgagcat gctgaccaag     3720

aaggcctgcc tgcacctgaa tcctggcggc acctgtgtgt ctatcggcta cggctatgcc     3780

gacagagcca gcgagtctat catcggcgcc attgccagac agttcaagtt cagcagagtg     3840

tgcaagccca agagcagcct ggaagagaca gaggtgctgt tcgtgttcat cggctatgac     3900

cggaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  8
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C08 nsP coding sequence DNA

<400>  8
atggaaaagg tgcacgtgga catcgaagag gacagcccat tcctgagagc cctgcagaga       60

agcttccctc agttcgaggt ggaagccaaa caagtgaccg acaacgatca cgccaacgcg      120

agggccttct ctcacctcgc aagcaagctg atcgagacag aggtggaccc cagcgacacc      180

atcctggata ttggatctgc ccctgccaga agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  9
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C09 nsP coding sequence DNA

<400>  9
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc cagaaatatc ggcctgtgta gcagcgacgt gatggaaaga      660

tccagacggg gcatgagcat cctgcggaag aagtacctga agcctagcaa caacgtgctg      720

ttcagcgtgg gcagcaccat ctaccacgag aagagggacc tgctgcggag ctggcatctg      780

ccttccgtgt ttcacctgag aggcaagcag aactacacct gtagatgcga gacaatcgtg      840

tcctgcgacg gctacgtggt caagcggatc gccatttctc ctggcctgta cggcaagcct      900

tctggctatg ccgccaccat gcacagagaa ggctttctgt gttgcaaagt gaccgacaca      960

ctgaacggcg agcgggtgtc ctttcctgtg tgtacctatg tgcccgccac actgtgcgat     1020

cagatgacag gcattctggc caccgacgtg tcagccgacg atgcccagaa actgctcgtg     1080

ggcctgaacc agagaatcgt ggtcaacggc agaacccagc ggaacaccaa caccatgaag     1140

aactacctgc tgcctgtggt ggcccaggcc tttgccagat gggccaaaga gtacaaagag     1200

gatcaagagg acgagcggcc cctgggcctg agagatagac aactggtcat gggctgctgc     1260

tgggccttca gaaggcacaa gatcaccagc atctacaagc ggcccgacac acagaccatc     1320

atcaaagtga acagcgactt ccacagcttc gtgctgcctc ggatcggcag caacacactg     1380

gaaatcggcc tgcggacccg gatcagaaag atgctggaag aacacaaaga gccctctcca     1440

ctgatcaccg ccgaggatgt gcaagaggcc aaatgtgccg ccgacgaggc taaagaagtg     1500

cgcgaagccg aggaactgag agccgcactt cctcctctgg ccgccgatgt tgaagaaccc     1560

actctggaag ccgacgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aagagcatca gcagacggtg caccaagagc gtgaccagcg tggtgtctac cctgttctac     2580

gacaagaaga tgcggacgac aaaccccaaa gagacaaaga tcgtcatcga caccaccggc     2640

agcaccaagc ctaagcagga cgatctgatc ctgacctgct tcagaggctg ggtcaagcag     2700

ctgcagatcg actacaaggg caacgagatc atgaccgccg ctgcctctca gggcctgaca     2760

agaaaaggcg tgtacgccgt gcggtacaaa gtgaacgaga accctctgta cgcccctacc     2820

agcgagcatg tgaatgtgct gctgacccgg accgaggacc ggatcgtttg gaaaacactg     2880

gccggcgatc cctggatcaa gaccctgaca gccaagtatc ccggcaactt caccgccacc     2940

atcgaggaat ggcaggccga gcacgatgcc atcatgcggc acatcctgga aagacccgat     3000

cctaccgacg tgttccagaa caaggccaac gtgtgctggg ccaaagctct ggtgcctgtg     3060

ctgaaaaccg ccggcatcga tatgaccacc gagcagtgga acaccgtgga ctacttcgag     3120

acagacaagg cccacagcgc cgagatcgtg ctgaatcagc tgtgcgtgcg gttcttcggc     3180

ctggatctgg atagcggcct gttctctgct cctaccgtgc ctctgagcat ccggaacaac     3240

cactgggaca acagcccctc tcctaatatg tacggcctga acaaagaagt cgtgcggcag     3300

ctgagcagaa gatacccaca gctgcctaga gccgtggcca caggcagagt gtacgacatg     3360

aataccggca cactgcggaa ctacgacccc agaatcaatc tggtgcccgt gaacagaagg     3420

ctgccccacg ctctggttct gcaccacaat gagcaccctc agagcgactt cagcagcttc     3480

gtgtccaagc tgaagggcag aaccgtgctg gttgtgggcg agaagctgtc tgtgcctggc     3540

aagatggtgg actggctgag cgatagaccc gaggccacct ttagagccag actggacctt     3600

ggaatccctg gcgacgtgcc caaatacgac atcatcttcg tgaacgtgcg gacgccctac     3660

aagtaccacc actaccagca gtgcgaggac cacgccatca agctgagcat gctgaccaag     3720

aaggcctgcc tgcacctgaa tcctggcggc acctgtgtgt ctatcggcta cggctatgcc     3780

gacagagcca gcgagtctat catcggcgcc attgccagac agttcaagtt cagcagagtg     3840

tgcaagccca agagcagcct ggaagagaca gaggtgctgt tcgtgttcat cggctatgac     3900

cggaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taaattcgga gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

accggatcac catgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  10
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C10 nsP coding sequence DNA

<400>  10
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccctac     3660

aagtaccacc actaccagca gtgcgaggac cacgccatca agctgagcat gctgaccaag     3720

aaggcctgcc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat cggctacgac     3900

agaaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaagtacgc ctgcaacaac     6360

gagtactggg agacattcaa agagaacccc atccggctga ccgaggaaaa cgtggtcaac     6420

tacatcacca agctgaaggg ccccaaagcc gccgctctgt ttgccaagac acacaacctg     6480

aacatgctgc aggacatccc catggacaga ttcgtgatgg acctgaagcg ggacgtgaaa     6540

gtgacccctg gcaccaagca caccgaggaa cggcctaagg tgcaagtgat ccaggccgct     6600

gatcctctgg ccacagccta tctgtgtggc atccacagag aactcgtgcg gagactgaat     6660

gccgtgctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgctga tgattctgga agatctcgga     6840

gtggacgccg agctgctgac actgattgaa gccgcctttg gcgagatcag cagcatccat     6900

ctgcctacca agaccaagtt caagttcggc gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

acaggcagcc cttgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  11
<211>  7482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C11 nsP coding sequence DNA

<400>  11
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat atgccgtgga tggccctaca      480

agcctgtacc accaggccaa caagggcgtc agagtggcct actggatcgg cttcgacacc      540

acacctttca tgttcaagaa cctggctggc gcttacccca gctacagcac aaactgggcc      600

gacgaaaccg tgttaacggc cagaaatatc ggcctgtgta gcagcgacgt gatggaaaga      660

tccagacggg gcatgagcat cctgcggaag aagtacctga agcctagcaa caacgtgctg      720

ttcagcgtgg gcagcaccat ctaccacgag aagagggacc tgctgcggag ctggcatctg      780

ccttccgtgt ttcacctgag aggcaagcag aactacacct gtagatgcga gacaatcgtg      840

tcctgcgacg gctacgtggt caagcggatc gccatttctc ctggcctgta cggcaagcct      900

tctggctatg ccgccaccat gcacagagaa ggctttctgt gttgcaaagt gaccgacaca      960

ctgaacggcg agcgggtgtc ctttcctgtg tgtacctatg tgcccgccac actgtgcgat     1020

cagatgacag gcattctggc caccgacgtg tcagccgacg atgcccagaa actgctcgtg     1080

ggcctgaacc agagaatcgt ggtcaacggc agaacccagc ggaacaccaa caccatgaag     1140

aactacctgc tgcctgtggt ggcccaggcc tttgccagat gggccaaaga gtacaaagag     1200

gatcaagagg acgagcggcc cctgggcctg agagatagac aactggtcat gggctgctgc     1260

tgggccttca gaaggcacaa gatcaccagc atctacaagc ggcccgacac acagaccatc     1320

atcaaagtga acagcgactt ccacagcttc gtgctgcctc ggatcggcag caacacactg     1380

gaaatcggcc tgcggacccg gatcagaaag atgctggaag aacacaaaga gccctctcca     1440

ctgatcaccg ccgaggatgt gcaagaggcc aaatgtgccg ccgacgaggc taaagaagtg     1500

cgcgaagccg aggaactgag agccgcactt cctcctctgg ccgccgatgt tgaagaaccc     1560

actctggaag ccgacgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagc gagaagctga gctgcattca ccctctggcc     1740

gagcaagtga tcgtgatcac acacagcggc cggaagggca gatatgccgt ggaaccttat     1800

cacggcaagg tggtggtgcc tgagggacac gctattccag tgcaggactt tcaggccctg     1860

agcgagtctg ccaccatcgt gtacaacgag cgcgagttcg tgaacagata cctgcaccac     1920

attgccacac acggcggagc cctgaacacc gacgaagagt actacaagac cgtgaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggat agcgtgctgc tgaacggctg caagcacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcctaagca gtgcggcttc     2460

ttcaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aagagcatca gcagacggtg caccaagagc gtgaccagcg tggtgtctac cctgttctac     2580

gacaagaaga tgcggacgac aaaccccaaa gagacaaaga tcgtcatcga caccaccggc     2640

agcaccaagc ctaagcagga cgatctgatc ctgacctgct tcagaggctg ggtcaagcag     2700

ctgcagatcg actacaaggg caacgagatc atgaccgccg ctgcctctca gggcctgaca     2760

agaaaaggcg tgtacgccgt gcggtacaaa gtgaacgaga accctctgta cgcccctacc     2820

agcgagcatg tgaatgtgct gctgacccgg accgaggacc ggatcgtttg gaaaacactg     2880

gccggcgatc cctggatcaa gaccctgaca gccaagtatc ccggcaactt caccgccacc     2940

atcgaggaat ggcaggccga gcacgatgcc atcatgcggc acatcctgga aagacccgat     3000

cctaccgacg tgttccagaa caaggccaac gtgtgctggg ccaaagctct ggtgcctgtg     3060

ctgaaaaccg ccggcatcga tatgaccacc gagcagtgga acaccgtgga ctacttcgag     3120

acagacaagg cccacagcgc cgagatcgtg ctgaatcagc tgtgcgtgcg gttcttcggc     3180

ctggatctgg atagcggcct gttctctgct cctaccgtgc ctctgagcat ccggaacaac     3240

cactgggaca acagcccctc tcctaatatg tacggcctga acaaagaagt cgtgcggcag     3300

ctgagcagaa gatacccaca gctgcctaga gccgtggcca caggcagagt gtacgacatg     3360

aataccggca cactgcggaa ctacgacccc agaatcaatc tggtgcccgt gaacagaagg     3420

ctgccccacg ctctggttct gcaccacaat gagcaccctc agagcgactt cagcagcttc     3480

gtgtccaagc tgaagggcag aaccgtgctg gttgtgggcg agaagctgtc tgtgcctggc     3540

aagatggtgg actggctgag cgatagaccc gaggccacct ttagagccag actggacctt     3600

ggaatccctg gcgacgtgcc caaatacgac atcatcttcg tgaacgtgcg gacgccctac     3660

aagtaccacc actaccagca gtgcgaggac cacgccatca agctgagcat gctgaccaag     3720

aaggcctgcc tgcacctgaa tcctggcggc acctgtgtgt ctatcggcta cggctatgcc     3780

gacagagcca gcgagtctat catcggcgcc attgccagac agttcaagtt cagcagagtg     3840

tgcaagccca agagcagcct ggaagagaca gaggtgctgt tcgtgttcat cggctatgac     3900

cggaaggccc gtacgcacaa cccctacaag ctgagcagca ccctgaccaa catctacacc     3960

ggcagcagac tgcacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacagcca cagaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaagtacgc ctgcaacaac     6360

gagtactggg agacattcaa agagaacccc atccggctga ccgaggaaaa cgtggtcaac     6420

tacatcacca agctgaaggg ccccaaagcc gccgctctgt ttgccaagac acacaacctg     6480

aacatgctgc aggacatccc catggacaga ttcgtgatgg acctgaagcg ggacgtgaaa     6540

gtgacccctg gcaccaagca caccgaggaa cggcctaagg tgcaagtgat ccaggccgct     6600

gatcctctgg ccacagccta tctgtgtggc atccacagag aactcgtgcg gagactgaat     6660

gccgtgctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgctga tgattctgga agatctcgga     6840

gtggacgccg agctgctgac actgattgaa gccgcctttg gcgagatcag cagcatccat     6900

ctgcctacca agaccaagtt caagttcggc gccatgatga aatctggaat gttcctcaca     6960

ctgtttgtga acacagtcat taacattgta atcgcaagca gagtgttgag agaacggcta     7020

acaggcagcc cttgtgcagc attcattgga gatgacaata tcgtgaaagg agtcaaatcg     7080

gacaaattaa tggcagacag gtgcgccacc tggttgaata tggaagtcaa gattatagat     7140

gctgtggtgg gcgagaaagc gccttatttc tgtggagggt ttattttgtg tgactccgtg     7200

accggcacag cgtgccgtgt ggcagacccc ctaaaaaggc tgtttaagct tggcaaacct     7260

ctggcagcag acgatgaaca tgatgatgac aggagaaggg cattgcatga agagtcaaca     7320

cgctggaacc gagtgggtat tctttcagag ctgtgcaagg cagtagaatc aaggtatgaa     7380

accgtaggaa cttccatcat agttatggcc atgactactc tagctagcag tgttaaatca     7440

ttcagctacc tgagaggggc ccctataact ctctacggct aa                        7482


<210>  12
<211>  2513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C16 nsP-2A protein amino acid


<220>
<221>  misc_feature
<222>  (1880)..(1880)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Glu Lys Val His Val Asp Ile Glu Glu Asp Ser Pro Phe Leu Arg 
1               5                   10                  15      


Ala Leu Gln Arg Ser Phe Pro Gln Phe Glu Val Glu Ala Lys Gln Val 
            20                  25                  30          


Thr Asp Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu Ala Ser 
        35                  40                  45              


Lys Leu Ile Glu Thr Glu Val Asp Pro Ser Asp Thr Ile Leu Asp Ile 
    50                  55                  60                  


Gly Ser Ala Pro Ala Arg Arg Met Tyr Ser Lys His Lys Tyr His Cys 
65                  70                  75                  80  


Ile Cys Pro Met Arg Cys Ala Glu Asp Pro Asp Arg Leu Tyr Lys Tyr 
                85                  90                  95      


Ala Thr Lys Leu Lys Lys Asn Cys Lys Glu Ile Thr Asp Lys Glu Leu 
            100                 105                 110         


Asp Lys Lys Met Lys Glu Leu Ala Ala Val Met Ser Asp Pro Asp Leu 
        115                 120                 125             


Glu Thr Glu Thr Met Cys Leu His Asp Asp Glu Ser Cys Arg Tyr Glu 
    130                 135                 140                 


Gly Gln Val Ala Val Tyr Gln Asp Val Tyr Ala Val Asp Gly Pro Thr 
145                 150                 155                 160 


Ser Leu Tyr His Gln Ala Asn Lys Gly Val Arg Val Ala Tyr Trp Ile 
                165                 170                 175     


Gly Phe Asp Thr Thr Pro Phe Met Phe Lys Asn Leu Ala Gly Ala Tyr 
            180                 185                 190         


Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Thr Val Leu Thr Ala Arg 
        195                 200                 205             


Asn Ile Gly Leu Cys Ser Ser Asp Val Met Glu Arg Ser Arg Arg Gly 
    210                 215                 220                 


Met Ser Ile Leu Arg Lys Lys Tyr Leu Lys Pro Ser Asn Asn Val Leu 
225                 230                 235                 240 


Phe Ser Val Gly Ser Thr Ile Tyr His Glu Lys Arg Asp Leu Leu Arg 
                245                 250                 255     


Ser Trp His Leu Pro Ser Val Phe His Leu Arg Gly Lys Gln Asn Tyr 
            260                 265                 270         


Thr Cys Arg Cys Glu Thr Ile Val Ser Cys Asp Gly Tyr Val Val Lys 
        275                 280                 285             


Arg Ile Ala Ile Ser Pro Gly Leu Tyr Gly Lys Pro Ser Gly Tyr Ala 
    290                 295                 300                 


Ala Thr Met His Arg Glu Gly Phe Leu Cys Cys Lys Val Thr Asp Thr 
305                 310                 315                 320 


Leu Asn Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Val Pro Ala 
                325                 330                 335     


Thr Leu Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Asp Val Ser Ala 
            340                 345                 350         


Asp Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val Val 
        355                 360                 365             


Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 
    370                 375                 380                 


Pro Val Val Ala Gln Ala Phe Ala Arg Trp Ala Lys Glu Tyr Lys Glu 
385                 390                 395                 400 


Asp Gln Glu Asp Glu Arg Pro Leu Gly Leu Arg Asp Arg Gln Leu Val 
                405                 410                 415     


Met Gly Cys Cys Trp Ala Phe Arg Arg His Lys Ile Thr Ser Ile Tyr 
            420                 425                 430         


Lys Arg Pro Asp Thr Gln Thr Ile Ile Lys Val Asn Ser Asp Phe His 
        435                 440                 445             


Ser Phe Val Leu Pro Arg Ile Gly Ser Asn Thr Leu Glu Ile Gly Leu 
    450                 455                 460                 


Arg Thr Arg Ile Arg Lys Met Leu Glu Glu His Lys Glu Pro Ser Pro 
465                 470                 475                 480 


Leu Ile Thr Ala Glu Asp Val Gln Glu Ala Lys Cys Ala Ala Asp Glu 
                485                 490                 495     


Ala Lys Glu Val Arg Glu Ala Glu Glu Leu Arg Ala Ala Leu Pro Pro 
            500                 505                 510         


Leu Ala Ala Asp Val Glu Glu Pro Thr Leu Glu Ala Asp Val Asp Leu 
        515                 520                 525             


Met Leu Gln Glu Ala Gly Ala Gly Ser Val Glu Thr Pro Arg Gly Leu 
    530                 535                 540                 


Ile Lys Val Thr Ser Tyr Ala Gly Glu Asp Lys Ile Gly Ser Tyr Ala 
545                 550                 555                 560 


Val Leu Ser Pro Gln Ala Val Leu Lys Ser Glu Lys Leu Ser Cys Ile 
                565                 570                 575     


His Pro Leu Ala Glu Gln Val Ile Val Ile Thr His Ser Gly Arg Lys 
            580                 585                 590         


Gly Arg Tyr Ala Val Glu Pro Tyr His Gly Lys Val Val Val Pro Glu 
        595                 600                 605             


Gly His Ala Ile Pro Val Gln Asp Phe Gln Ala Leu Ser Glu Ser Ala 
    610                 615                 620                 


Thr Ile Val Tyr Asn Glu Arg Glu Phe Val Asn Arg Tyr Leu His His 
625                 630                 635                 640 


Ile Ala Thr His Gly Gly Ala Leu Asn Thr Asp Glu Glu Tyr Tyr Lys 
                645                 650                 655     


Thr Val Lys Pro Ser Glu His Asp Gly Glu Tyr Leu Tyr Asp Ile Asp 
            660                 665                 670         


Arg Lys Gln Cys Val Lys Lys Glu Leu Val Thr Gly Leu Gly Leu Thr 
        675                 680                 685             


Gly Glu Leu Val Asp Pro Pro Phe His Glu Phe Ala Tyr Glu Ser Leu 
    690                 695                 700                 


Arg Thr Arg Pro Ala Ala Pro Tyr Gln Val Pro Thr Ile Gly Val Tyr 
705                 710                 715                 720 


Gly Val Pro Gly Ser Gly Lys Ser Gly Ile Ile Lys Ser Ala Val Thr 
                725                 730                 735     


Lys Lys Asp Leu Val Val Ser Ala Lys Lys Glu Asn Cys Ala Glu Ile 
            740                 745                 750         


Ile Arg Asp Val Lys Lys Met Lys Gly Leu Asp Val Asn Ala Arg Thr 
        755                 760                 765             


Val Asp Ser Val Leu Leu Asn Gly Cys Lys His Pro Val Glu Thr Leu 
    770                 775                 780                 


Tyr Ile Asp Glu Ala Phe Ala Cys His Ala Gly Thr Leu Arg Ala Leu 
785                 790                 795                 800 


Ile Ala Ile Ile Arg Pro Lys Lys Ala Val Leu Cys Gly Asp Pro Lys 
                805                 810                 815     


Gln Cys Gly Phe Phe Asn Met Met Cys Leu Lys Val His Phe Asn His 
            820                 825                 830         


Glu Ile Cys Thr Gln Val Phe His Lys Ser Ile Ser Arg Arg Cys Thr 
        835                 840                 845             


Lys Ser Val Thr Ser Val Val Ser Thr Leu Phe Tyr Asp Lys Lys Met 
    850                 855                 860                 


Arg Thr Thr Asn Pro Lys Glu Thr Lys Ile Val Ile Asp Thr Thr Gly 
865                 870                 875                 880 


Ser Thr Lys Pro Lys Gln Asp Asp Leu Ile Leu Thr Cys Phe Arg Gly 
                885                 890                 895     


Trp Val Lys Gln Leu Gln Ile Asp Tyr Lys Gly Asn Glu Ile Met Thr 
            900                 905                 910         


Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly Val Tyr Ala Val Arg 
        915                 920                 925             


Tyr Lys Val Asn Glu Asn Pro Leu Tyr Ala Pro Thr Ser Glu His Val 
    930                 935                 940                 


Asn Val Leu Leu Thr Arg Thr Glu Asp Arg Ile Val Trp Lys Thr Leu 
945                 950                 955                 960 


Ala Gly Asp Pro Trp Ile Lys Thr Leu Thr Ala Lys Tyr Pro Gly Asn 
                965                 970                 975     


Phe Thr Ala Thr Ile Glu Glu Trp Gln Ala Glu His Asp Ala Ile Met 
            980                 985                 990         


Arg His Ile Leu Glu Arg Pro Asp  Pro Thr Asp Val Phe  Gln Asn Lys 
        995                 1000                 1005             


Ala Asn  Val Cys Trp Ala Lys  Ala Leu Val Pro Val  Leu Lys Thr 
    1010                 1015                 1020             


Ala Gly  Ile Asp Met Thr Thr  Glu Gln Trp Asn Thr  Val Asp Tyr 
    1025                 1030                 1035             


Phe Glu  Thr Asp Lys Ala His  Ser Ala Glu Ile Val  Leu Asn Gln 
    1040                 1045                 1050             


Leu Cys  Val Arg Phe Phe Gly  Leu Asp Leu Asp Ser  Gly Leu Phe 
    1055                 1060                 1065             


Ser Ala  Pro Thr Val Pro Leu  Ser Ile Arg Asn Asn  His Trp Asp 
    1070                 1075                 1080             


Asn Ser  Pro Ser Pro Asn Met  Tyr Gly Leu Asn Lys  Glu Val Val 
    1085                 1090                 1095             


Arg Gln  Leu Ser Arg Arg Tyr  Pro Gln Leu Pro Arg  Ala Val Ala 
    1100                 1105                 1110             


Thr Gly  Arg Val Tyr Asp Met  Asn Thr Gly Thr Leu  Arg Asn Tyr 
    1115                 1120                 1125             


Asp Pro  Arg Ile Asn Leu Val  Pro Val Asn Arg Arg  Leu Pro His 
    1130                 1135                 1140             


Ala Leu  Val Leu His His Asn  Glu His Pro Gln Ser  Asp Phe Ser 
    1145                 1150                 1155             


Ser Phe  Val Ser Lys Leu Lys  Gly Arg Thr Val Leu  Val Val Gly 
    1160                 1165                 1170             


Glu Lys  Leu Ser Val Pro Gly  Lys Met Val Asp Trp  Leu Ser Asp 
    1175                 1180                 1185             


Arg Pro  Glu Ala Thr Phe Arg  Ala Arg Leu Asp Leu  Gly Ile Pro 
    1190                 1195                 1200             


Gly Asp  Val Pro Lys Tyr Asp  Ile Ile Phe Val Asn  Val Arg Thr 
    1205                 1210                 1215             


Pro Tyr  Lys Tyr His His Tyr  Gln Gln Cys Glu Asp  His Ala Ile 
    1220                 1225                 1230             


Lys Leu  Ser Met Leu Thr Lys  Lys Ala Cys Leu His  Leu Asn Pro 
    1235                 1240                 1245             


Gly Gly  Thr Cys Val Ser Ile  Gly Tyr Gly Tyr Ala  Asp Arg Ala 
    1250                 1255                 1260             


Ser Glu  Ser Ile Ile Gly Ala  Ile Ala Arg Gln Phe  Lys Phe Ser 
    1265                 1270                 1275             


Arg Val  Cys Lys Pro Lys Ser  Ser Leu Glu Glu Thr  Glu Val Leu 
    1280                 1285                 1290             


Phe Val  Phe Ile Gly Tyr Asp  Arg Lys Ala Arg Thr  His Asn Pro 
    1295                 1300                 1305             


Tyr Lys  Leu Ser Ser Thr Leu  Thr Asn Ile Tyr Thr  Gly Ser Arg 
    1310                 1315                 1320             


Leu His  Glu Ala Gly Cys Ala  Pro Ser Tyr His Val  Val Arg Gly 
    1325                 1330                 1335             


Asp Ile  Ala Thr Ala Thr Glu  Gly Val Ile Ile Asn  Ala Ala Asn 
    1340                 1345                 1350             


Ser Lys  Gly Gln Pro Gly Gly  Gly Val Cys Gly Ala  Leu Tyr Lys 
    1355                 1360                 1365             


Lys Phe  Pro Glu Ser Phe Asp  Leu Gln Pro Ile Glu  Val Gly Lys 
    1370                 1375                 1380             


Ala Arg  Leu Val Lys Gly Ala  Ala Lys His Ile Ile  His Ala Val 
    1385                 1390                 1395             


Gly Pro  Asn Phe Asn Lys Val  Ser Glu Val Glu Gly  Asp Lys Gln 
    1400                 1405                 1410             


Leu Ala  Glu Ala Tyr Glu Ser  Ile Ala Lys Ile Val  Asn Asp Asn 
    1415                 1420                 1425             


Asn Tyr  Lys Ser Val Ala Ile  Pro Leu Leu Ser Thr  Gly Ile Phe 
    1430                 1435                 1440             


Ser Gly  Asn Lys Asp Arg Leu  Thr Gln Ser Leu Asn  His Leu Leu 
    1445                 1450                 1455             


Thr Ala  Leu Asp Thr Thr Asp  Ala Asp Val Ala Ile  Tyr Cys Arg 
    1460                 1465                 1470             


Asp Lys  Lys Trp Glu Met Thr  Leu Lys Glu Ala Val  Ala Arg Arg 
    1475                 1480                 1485             


Glu Ala  Val Glu Glu Ile Cys  Ile Ser Asp Asp Ser  Ser Val Thr 
    1490                 1495                 1500             


Glu Pro  Asp Ala Glu Leu Val  Arg Val His Pro Lys  Ser Ser Leu 
    1505                 1510                 1515             


Ala Gly  Arg Lys Gly Tyr Ser  Thr Ser Asp Gly Lys  Thr Phe Ser 
    1520                 1525                 1530             


Tyr Leu  Glu Gly Thr Lys Phe  His Gln Ala Ala Lys  Asp Ile Ala 
    1535                 1540                 1545             


Glu Ile  Asn Ala Met Trp Pro  Val Ala Thr Glu Ala  Asn Glu Gln 
    1550                 1555                 1560             


Val Cys  Met Tyr Ile Leu Gly  Glu Ser Met Ser Ser  Ile Arg Ser 
    1565                 1570                 1575             


Lys Cys  Pro Val Glu Glu Ser  Glu Ala Ser Thr Pro  Pro Ser Thr 
    1580                 1585                 1590             


Leu Pro  Cys Leu Cys Ile His  Ala Met Thr Pro Glu  Arg Val Gln 
    1595                 1600                 1605             


Arg Leu  Lys Ala Ser Arg Pro  Glu Gln Ile Thr Val  Cys Ser Ser 
    1610                 1615                 1620             


Phe Pro  Leu Pro Lys Tyr Arg  Ile Thr Gly Val Gln  Lys Ile Gln 
    1625                 1630                 1635             


Cys Ser  Gln Pro Ile Leu Phe  Ser Pro Lys Val Pro  Ala Tyr Ile 
    1640                 1645                 1650             


His Pro  Arg Lys Tyr Leu Val  Glu Thr Pro Pro Val  Asp Glu Thr 
    1655                 1660                 1665             


Pro Glu  Pro Ser Ala Glu Asn  Gln Ser Thr Glu Gly  Thr Pro Glu 
    1670                 1675                 1680             


Gln Pro  Pro Leu Ile Thr Glu  Asp Glu Thr Arg Thr  Arg Thr Pro 
    1685                 1690                 1695             


Glu Pro  Ile Ile Ile Glu Glu  Glu Glu Glu Asp Ser  Ile Ser Leu 
    1700                 1705                 1710             


Leu Ser  Asp Gly Pro Thr His  Gln Val Leu Gln Val  Glu Ala Asp 
    1715                 1720                 1725             


Ile His  Gly Pro Pro Ser Val  Ser Ser Ser Ser Trp  Ser Ile Pro 
    1730                 1735                 1740             


His Ala  Ser Asp Phe Asp Val  Asp Ser Leu Ser Ile  Leu Asp Thr 
    1745                 1750                 1755             


Leu Glu  Gly Ala Ser Val Thr  Ser Gly Ala Thr Ser  Ala Glu Thr 
    1760                 1765                 1770             


Asn Ser  Tyr Phe Ala Lys Ser  Met Glu Phe Leu Ala  Arg Pro Val 
    1775                 1780                 1785             


Pro Ala  Pro Arg Thr Val Phe  Arg Asn Pro Pro His  Pro Ala Pro 
    1790                 1795                 1800             


Arg Thr  Arg Thr Pro Ser Leu  Ala Pro Ser Arg Ala  Cys Ser Arg 
    1805                 1810                 1815             


Thr Ser  Leu Val Ser Thr Pro  Pro Gly Val Asn Arg  Val Ile Thr 
    1820                 1825                 1830             


Arg Glu  Glu Leu Glu Ala Leu  Thr Pro Ser Arg Thr  Pro Ser Arg 
    1835                 1840                 1845             


Ser Val  Ser Arg Thr Ser Leu  Val Ser Asn Pro Pro  Gly Val Asn 
    1850                 1855                 1860             


Arg Val  Ile Thr Arg Glu Glu  Phe Glu Ala Phe Val  Ala Gln Gln 
    1865                 1870                 1875             


Gln Xaa  Arg Phe Asp Ala Gly  Ala Tyr Ile Phe Ser  Ser Asp Thr 
    1880                 1885                 1890             


Gly Gln  Gly His Leu Gln Gln  Lys Ser Val Arg Gln  Thr Val Leu 
    1895                 1900                 1905             


Ser Glu  Val Val Leu Glu Arg  Thr Glu Leu Glu Ile  Ser Tyr Ala 
    1910                 1915                 1920             


Pro Arg  Leu Asp Gln Glu Lys  Glu Glu Leu Leu Arg  Lys Lys Leu 
    1925                 1930                 1935             


Gln Leu  Asn Pro Thr Pro Ala  Asn Arg Ser Arg Tyr  Gln Ser Arg 
    1940                 1945                 1950             


Lys Val  Glu Asn Met Lys Ala  Ile Thr Ala Arg Arg  Ile Leu Gln 
    1955                 1960                 1965             


Gly Leu  Gly His Tyr Leu Lys  Ala Glu Gly Lys Val  Glu Cys Tyr 
    1970                 1975                 1980             


Arg Thr  Leu His Pro Val Pro  Leu Tyr Ser Ser Ser  Val Asn Arg 
    1985                 1990                 1995             


Ala Phe  Ser Ser Pro Lys Val  Ala Val Glu Ala Cys  Asn Ala Met 
    2000                 2005                 2010             


Leu Lys  Glu Asn Phe Pro Thr  Val Ala Ser Tyr Cys  Ile Ile Pro 
    2015                 2020                 2025             


Glu Tyr  Asp Ala Tyr Leu Asp  Met Val Asp Gly Ala  Ser Cys Cys 
    2030                 2035                 2040             


Leu Asp  Thr Ala Ser Phe Cys  Pro Ala Lys Leu Arg  Ser Phe Pro 
    2045                 2050                 2055             


Lys Lys  His Ser Tyr Leu Glu  Pro Thr Ile Arg Ser  Ala Val Pro 
    2060                 2065                 2070             


Ser Ala  Ile Gln Asn Thr Leu  Gln Asn Val Leu Ala  Ala Ala Thr 
    2075                 2080                 2085             


Lys Arg  Asn Cys Asn Val Thr  Gln Met Arg Glu Leu  Pro Val Leu 
    2090                 2095                 2100             


Asp Ser  Ala Ala Phe Asn Val  Glu Cys Phe Lys Lys  Tyr Ala Cys 
    2105                 2110                 2115             


Asn Asn  Glu Tyr Trp Glu Thr  Phe Lys Glu Asn Pro  Ile Arg Leu 
    2120                 2125                 2130             


Thr Glu  Glu Asn Val Val Asn  Tyr Ile Thr Lys Leu  Lys Gly Pro 
    2135                 2140                 2145             


Lys Ala  Ala Ala Leu Phe Ala  Lys Thr His Asn Leu  Asn Met Leu 
    2150                 2155                 2160             


Gln Asp  Ile Pro Met Asp Arg  Phe Val Met Asp Leu  Lys Arg Asp 
    2165                 2170                 2175             


Val Lys  Val Thr Pro Gly Thr  Lys His Thr Glu Glu  Arg Pro Lys 
    2180                 2185                 2190             


Val Gln  Val Ile Gln Ala Ala  Asp Pro Leu Ala Thr  Ala Tyr Leu 
    2195                 2200                 2205             


Cys Gly  Ile His Arg Glu Leu  Val Arg Arg Leu Asn  Ala Val Leu 
    2210                 2215                 2220             


Leu Pro  Asn Ile His Thr Leu  Phe Asp Met Ser Ala  Glu Asp Phe 
    2225                 2230                 2235             


Asp Ala  Ile Ile Ala Glu His  Phe Gln Pro Gly Asp  Cys Val Leu 
    2240                 2245                 2250             


Glu Thr  Asp Ile Ala Ser Phe  Asp Lys Ser Glu Asp  Asp Ala Met 
    2255                 2260                 2265             


Ala Leu  Thr Ala Leu Met Ile  Leu Glu Asp Leu Gly  Val Asp Ala 
    2270                 2275                 2280             


Glu Leu  Leu Thr Leu Ile Glu  Ala Ala Phe Gly Glu  Ile Ser Ser 
    2285                 2290                 2295             


Ile His  Leu Pro Thr Lys Thr  Lys Phe Lys Phe Gly  Ala Met Met 
    2300                 2305                 2310             


Lys Ser  Gly Met Phe Leu Thr  Leu Phe Val Asn Thr  Val Ile Asn 
    2315                 2320                 2325             


Ile Val  Ile Ala Ser Arg Val  Leu Arg Glu Arg Leu  Thr Gly Ser 
    2330                 2335                 2340             


Pro Cys  Ala Ala Phe Ile Gly  Asp Asp Asn Ile Val  Lys Gly Val 
    2345                 2350                 2355             


Lys Ser  Asp Lys Leu Met Ala  Asp Arg Cys Ala Thr  Trp Leu Asn 
    2360                 2365                 2370             


Met Glu  Val Lys Ile Ile Asp  Ala Val Val Gly Glu  Lys Ala Pro 
    2375                 2380                 2385             


Tyr Phe  Cys Gly Gly Phe Ile  Leu Cys Asp Ser Val  Thr Gly Thr 
    2390                 2395                 2400             


Ala Cys  Arg Val Ala Asp Pro  Leu Lys Arg Leu Phe  Lys Leu Gly 
    2405                 2410                 2415             


Lys Pro  Leu Ala Ala Asp Asp  Glu His Asp Asp Asp  Arg Arg Arg 
    2420                 2425                 2430             


Ala Leu  His Glu Glu Ser Thr  Arg Trp Asn Arg Val  Gly Ile Leu 
    2435                 2440                 2445             


Ser Glu  Leu Cys Lys Ala Val  Glu Ser Arg Tyr Glu  Thr Val Gly 
    2450                 2455                 2460             


Thr Ser  Ile Ile Val Met Ala  Met Thr Thr Leu Ala  Ser Ser Val 
    2465                 2470                 2475             


Lys Ser  Phe Ser Tyr Leu Arg  Gly Ala Pro Ile Thr  Leu Tyr Gly 
    2480                 2485                 2490             


Ser Gly  Glu Gly Arg Gly Ser  Leu Leu Thr Cys Gly  Asp Val Glu 
    2495                 2500                 2505             


Glu Asn  Pro Gly Pro 
    2510             


<210>  13
<211>  7539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C16 nsP-2A coding sequence DNA

<400>  13
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taagttcggc gccatgatga agtccggcat gtttctgacc     6960

ctgttcgtga acaccgtgat caacatcgtg atcgccagcc gggtgctgag agagagactg     7020

acaggatctc cttgcgccgc cttcatcggc gacgacaata tcgtgaaggg cgtgaagtcc     7080

gacaagctga tggccgatag atgcgccacc tggctgaaca tggaagtgaa gatcatcgac     7140

gccgtcgtgg gcgagaaggc cccttatttt tgcggcggct tcatcctgtg cgacagcgtg     7200

acaggcacag cctgcagagt tgccgatcct ctgaagcggc tgttcaagct gggaaaacct     7260

ctggccgccg acgacgagca cgacgacgat agacgtagag ccctgcacga ggaatccacc     7320

agatggaaca gagtgggcat cctgagcgag ctgtgcaagg ccgtggaaag cagatacgag     7380

acagtgggca ccagcatcat tgtgatggca atgaccacac tggccagcag cgtgaaaagc     7440

ttcagctacc taaggggcgc ccctatcaca ctgtacggct ctggcgaagg cagaggcagc     7500

cttctgacat gtggcgacgt ggaagagaac cccggacct                            7539


<210>  14
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C16 subgenomic promoter  DNA

<400>  14
acttccatca tagttatggc catgactact ctagctagca gtgttaaatc attcagctac       60

ctgagagggg cccctataac tctctacggc taacctgaat ggactacgac atagtctagt      120

ccgccaag                                                               128


<210>  15
<211>  2751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C16 nsP-2A-eGFP protein


<220>
<221>  misc_feature
<222>  (1880)..(1880)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Glu Lys Val His Val Asp Ile Glu Glu Asp Ser Pro Phe Leu Arg 
1               5                   10                  15      


Ala Leu Gln Arg Ser Phe Pro Gln Phe Glu Val Glu Ala Lys Gln Val 
            20                  25                  30          


Thr Asp Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu Ala Ser 
        35                  40                  45              


Lys Leu Ile Glu Thr Glu Val Asp Pro Ser Asp Thr Ile Leu Asp Ile 
    50                  55                  60                  


Gly Ser Ala Pro Ala Arg Arg Met Tyr Ser Lys His Lys Tyr His Cys 
65                  70                  75                  80  


Ile Cys Pro Met Arg Cys Ala Glu Asp Pro Asp Arg Leu Tyr Lys Tyr 
                85                  90                  95      


Ala Thr Lys Leu Lys Lys Asn Cys Lys Glu Ile Thr Asp Lys Glu Leu 
            100                 105                 110         


Asp Lys Lys Met Lys Glu Leu Ala Ala Val Met Ser Asp Pro Asp Leu 
        115                 120                 125             


Glu Thr Glu Thr Met Cys Leu His Asp Asp Glu Ser Cys Arg Tyr Glu 
    130                 135                 140                 


Gly Gln Val Ala Val Tyr Gln Asp Val Tyr Ala Val Asp Gly Pro Thr 
145                 150                 155                 160 


Ser Leu Tyr His Gln Ala Asn Lys Gly Val Arg Val Ala Tyr Trp Ile 
                165                 170                 175     


Gly Phe Asp Thr Thr Pro Phe Met Phe Lys Asn Leu Ala Gly Ala Tyr 
            180                 185                 190         


Pro Ser Tyr Ser Thr Asn Trp Ala Asp Glu Thr Val Leu Thr Ala Arg 
        195                 200                 205             


Asn Ile Gly Leu Cys Ser Ser Asp Val Met Glu Arg Ser Arg Arg Gly 
    210                 215                 220                 


Met Ser Ile Leu Arg Lys Lys Tyr Leu Lys Pro Ser Asn Asn Val Leu 
225                 230                 235                 240 


Phe Ser Val Gly Ser Thr Ile Tyr His Glu Lys Arg Asp Leu Leu Arg 
                245                 250                 255     


Ser Trp His Leu Pro Ser Val Phe His Leu Arg Gly Lys Gln Asn Tyr 
            260                 265                 270         


Thr Cys Arg Cys Glu Thr Ile Val Ser Cys Asp Gly Tyr Val Val Lys 
        275                 280                 285             


Arg Ile Ala Ile Ser Pro Gly Leu Tyr Gly Lys Pro Ser Gly Tyr Ala 
    290                 295                 300                 


Ala Thr Met His Arg Glu Gly Phe Leu Cys Cys Lys Val Thr Asp Thr 
305                 310                 315                 320 


Leu Asn Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Val Pro Ala 
                325                 330                 335     


Thr Leu Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Asp Val Ser Ala 
            340                 345                 350         


Asp Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val Val 
        355                 360                 365             


Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu Leu 
    370                 375                 380                 


Pro Val Val Ala Gln Ala Phe Ala Arg Trp Ala Lys Glu Tyr Lys Glu 
385                 390                 395                 400 


Asp Gln Glu Asp Glu Arg Pro Leu Gly Leu Arg Asp Arg Gln Leu Val 
                405                 410                 415     


Met Gly Cys Cys Trp Ala Phe Arg Arg His Lys Ile Thr Ser Ile Tyr 
            420                 425                 430         


Lys Arg Pro Asp Thr Gln Thr Ile Ile Lys Val Asn Ser Asp Phe His 
        435                 440                 445             


Ser Phe Val Leu Pro Arg Ile Gly Ser Asn Thr Leu Glu Ile Gly Leu 
    450                 455                 460                 


Arg Thr Arg Ile Arg Lys Met Leu Glu Glu His Lys Glu Pro Ser Pro 
465                 470                 475                 480 


Leu Ile Thr Ala Glu Asp Val Gln Glu Ala Lys Cys Ala Ala Asp Glu 
                485                 490                 495     


Ala Lys Glu Val Arg Glu Ala Glu Glu Leu Arg Ala Ala Leu Pro Pro 
            500                 505                 510         


Leu Ala Ala Asp Val Glu Glu Pro Thr Leu Glu Ala Asp Val Asp Leu 
        515                 520                 525             


Met Leu Gln Glu Ala Gly Ala Gly Ser Val Glu Thr Pro Arg Gly Leu 
    530                 535                 540                 


Ile Lys Val Thr Ser Tyr Ala Gly Glu Asp Lys Ile Gly Ser Tyr Ala 
545                 550                 555                 560 


Val Leu Ser Pro Gln Ala Val Leu Lys Ser Glu Lys Leu Ser Cys Ile 
                565                 570                 575     


His Pro Leu Ala Glu Gln Val Ile Val Ile Thr His Ser Gly Arg Lys 
            580                 585                 590         


Gly Arg Tyr Ala Val Glu Pro Tyr His Gly Lys Val Val Val Pro Glu 
        595                 600                 605             


Gly His Ala Ile Pro Val Gln Asp Phe Gln Ala Leu Ser Glu Ser Ala 
    610                 615                 620                 


Thr Ile Val Tyr Asn Glu Arg Glu Phe Val Asn Arg Tyr Leu His His 
625                 630                 635                 640 


Ile Ala Thr His Gly Gly Ala Leu Asn Thr Asp Glu Glu Tyr Tyr Lys 
                645                 650                 655     


Thr Val Lys Pro Ser Glu His Asp Gly Glu Tyr Leu Tyr Asp Ile Asp 
            660                 665                 670         


Arg Lys Gln Cys Val Lys Lys Glu Leu Val Thr Gly Leu Gly Leu Thr 
        675                 680                 685             


Gly Glu Leu Val Asp Pro Pro Phe His Glu Phe Ala Tyr Glu Ser Leu 
    690                 695                 700                 


Arg Thr Arg Pro Ala Ala Pro Tyr Gln Val Pro Thr Ile Gly Val Tyr 
705                 710                 715                 720 


Gly Val Pro Gly Ser Gly Lys Ser Gly Ile Ile Lys Ser Ala Val Thr 
                725                 730                 735     


Lys Lys Asp Leu Val Val Ser Ala Lys Lys Glu Asn Cys Ala Glu Ile 
            740                 745                 750         


Ile Arg Asp Val Lys Lys Met Lys Gly Leu Asp Val Asn Ala Arg Thr 
        755                 760                 765             


Val Asp Ser Val Leu Leu Asn Gly Cys Lys His Pro Val Glu Thr Leu 
    770                 775                 780                 


Tyr Ile Asp Glu Ala Phe Ala Cys His Ala Gly Thr Leu Arg Ala Leu 
785                 790                 795                 800 


Ile Ala Ile Ile Arg Pro Lys Lys Ala Val Leu Cys Gly Asp Pro Lys 
                805                 810                 815     


Gln Cys Gly Phe Phe Asn Met Met Cys Leu Lys Val His Phe Asn His 
            820                 825                 830         


Glu Ile Cys Thr Gln Val Phe His Lys Ser Ile Ser Arg Arg Cys Thr 
        835                 840                 845             


Lys Ser Val Thr Ser Val Val Ser Thr Leu Phe Tyr Asp Lys Lys Met 
    850                 855                 860                 


Arg Thr Thr Asn Pro Lys Glu Thr Lys Ile Val Ile Asp Thr Thr Gly 
865                 870                 875                 880 


Ser Thr Lys Pro Lys Gln Asp Asp Leu Ile Leu Thr Cys Phe Arg Gly 
                885                 890                 895     


Trp Val Lys Gln Leu Gln Ile Asp Tyr Lys Gly Asn Glu Ile Met Thr 
            900                 905                 910         


Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly Val Tyr Ala Val Arg 
        915                 920                 925             


Tyr Lys Val Asn Glu Asn Pro Leu Tyr Ala Pro Thr Ser Glu His Val 
    930                 935                 940                 


Asn Val Leu Leu Thr Arg Thr Glu Asp Arg Ile Val Trp Lys Thr Leu 
945                 950                 955                 960 


Ala Gly Asp Pro Trp Ile Lys Thr Leu Thr Ala Lys Tyr Pro Gly Asn 
                965                 970                 975     


Phe Thr Ala Thr Ile Glu Glu Trp Gln Ala Glu His Asp Ala Ile Met 
            980                 985                 990         


Arg His Ile Leu Glu Arg Pro Asp  Pro Thr Asp Val Phe  Gln Asn Lys 
        995                 1000                 1005             


Ala Asn  Val Cys Trp Ala Lys  Ala Leu Val Pro Val  Leu Lys Thr 
    1010                 1015                 1020             


Ala Gly  Ile Asp Met Thr Thr  Glu Gln Trp Asn Thr  Val Asp Tyr 
    1025                 1030                 1035             


Phe Glu  Thr Asp Lys Ala His  Ser Ala Glu Ile Val  Leu Asn Gln 
    1040                 1045                 1050             


Leu Cys  Val Arg Phe Phe Gly  Leu Asp Leu Asp Ser  Gly Leu Phe 
    1055                 1060                 1065             


Ser Ala  Pro Thr Val Pro Leu  Ser Ile Arg Asn Asn  His Trp Asp 
    1070                 1075                 1080             


Asn Ser  Pro Ser Pro Asn Met  Tyr Gly Leu Asn Lys  Glu Val Val 
    1085                 1090                 1095             


Arg Gln  Leu Ser Arg Arg Tyr  Pro Gln Leu Pro Arg  Ala Val Ala 
    1100                 1105                 1110             


Thr Gly  Arg Val Tyr Asp Met  Asn Thr Gly Thr Leu  Arg Asn Tyr 
    1115                 1120                 1125             


Asp Pro  Arg Ile Asn Leu Val  Pro Val Asn Arg Arg  Leu Pro His 
    1130                 1135                 1140             


Ala Leu  Val Leu His His Asn  Glu His Pro Gln Ser  Asp Phe Ser 
    1145                 1150                 1155             


Ser Phe  Val Ser Lys Leu Lys  Gly Arg Thr Val Leu  Val Val Gly 
    1160                 1165                 1170             


Glu Lys  Leu Ser Val Pro Gly  Lys Met Val Asp Trp  Leu Ser Asp 
    1175                 1180                 1185             


Arg Pro  Glu Ala Thr Phe Arg  Ala Arg Leu Asp Leu  Gly Ile Pro 
    1190                 1195                 1200             


Gly Asp  Val Pro Lys Tyr Asp  Ile Ile Phe Val Asn  Val Arg Thr 
    1205                 1210                 1215             


Pro Tyr  Lys Tyr His His Tyr  Gln Gln Cys Glu Asp  His Ala Ile 
    1220                 1225                 1230             


Lys Leu  Ser Met Leu Thr Lys  Lys Ala Cys Leu His  Leu Asn Pro 
    1235                 1240                 1245             


Gly Gly  Thr Cys Val Ser Ile  Gly Tyr Gly Tyr Ala  Asp Arg Ala 
    1250                 1255                 1260             


Ser Glu  Ser Ile Ile Gly Ala  Ile Ala Arg Gln Phe  Lys Phe Ser 
    1265                 1270                 1275             


Arg Val  Cys Lys Pro Lys Ser  Ser Leu Glu Glu Thr  Glu Val Leu 
    1280                 1285                 1290             


Phe Val  Phe Ile Gly Tyr Asp  Arg Lys Ala Arg Thr  His Asn Pro 
    1295                 1300                 1305             


Tyr Lys  Leu Ser Ser Thr Leu  Thr Asn Ile Tyr Thr  Gly Ser Arg 
    1310                 1315                 1320             


Leu His  Glu Ala Gly Cys Ala  Pro Ser Tyr His Val  Val Arg Gly 
    1325                 1330                 1335             


Asp Ile  Ala Thr Ala Thr Glu  Gly Val Ile Ile Asn  Ala Ala Asn 
    1340                 1345                 1350             


Ser Lys  Gly Gln Pro Gly Gly  Gly Val Cys Gly Ala  Leu Tyr Lys 
    1355                 1360                 1365             


Lys Phe  Pro Glu Ser Phe Asp  Leu Gln Pro Ile Glu  Val Gly Lys 
    1370                 1375                 1380             


Ala Arg  Leu Val Lys Gly Ala  Ala Lys His Ile Ile  His Ala Val 
    1385                 1390                 1395             


Gly Pro  Asn Phe Asn Lys Val  Ser Glu Val Glu Gly  Asp Lys Gln 
    1400                 1405                 1410             


Leu Ala  Glu Ala Tyr Glu Ser  Ile Ala Lys Ile Val  Asn Asp Asn 
    1415                 1420                 1425             


Asn Tyr  Lys Ser Val Ala Ile  Pro Leu Leu Ser Thr  Gly Ile Phe 
    1430                 1435                 1440             


Ser Gly  Asn Lys Asp Arg Leu  Thr Gln Ser Leu Asn  His Leu Leu 
    1445                 1450                 1455             


Thr Ala  Leu Asp Thr Thr Asp  Ala Asp Val Ala Ile  Tyr Cys Arg 
    1460                 1465                 1470             


Asp Lys  Lys Trp Glu Met Thr  Leu Lys Glu Ala Val  Ala Arg Arg 
    1475                 1480                 1485             


Glu Ala  Val Glu Glu Ile Cys  Ile Ser Asp Asp Ser  Ser Val Thr 
    1490                 1495                 1500             


Glu Pro  Asp Ala Glu Leu Val  Arg Val His Pro Lys  Ser Ser Leu 
    1505                 1510                 1515             


Ala Gly  Arg Lys Gly Tyr Ser  Thr Ser Asp Gly Lys  Thr Phe Ser 
    1520                 1525                 1530             


Tyr Leu  Glu Gly Thr Lys Phe  His Gln Ala Ala Lys  Asp Ile Ala 
    1535                 1540                 1545             


Glu Ile  Asn Ala Met Trp Pro  Val Ala Thr Glu Ala  Asn Glu Gln 
    1550                 1555                 1560             


Val Cys  Met Tyr Ile Leu Gly  Glu Ser Met Ser Ser  Ile Arg Ser 
    1565                 1570                 1575             


Lys Cys  Pro Val Glu Glu Ser  Glu Ala Ser Thr Pro  Pro Ser Thr 
    1580                 1585                 1590             


Leu Pro  Cys Leu Cys Ile His  Ala Met Thr Pro Glu  Arg Val Gln 
    1595                 1600                 1605             


Arg Leu  Lys Ala Ser Arg Pro  Glu Gln Ile Thr Val  Cys Ser Ser 
    1610                 1615                 1620             


Phe Pro  Leu Pro Lys Tyr Arg  Ile Thr Gly Val Gln  Lys Ile Gln 
    1625                 1630                 1635             


Cys Ser  Gln Pro Ile Leu Phe  Ser Pro Lys Val Pro  Ala Tyr Ile 
    1640                 1645                 1650             


His Pro  Arg Lys Tyr Leu Val  Glu Thr Pro Pro Val  Asp Glu Thr 
    1655                 1660                 1665             


Pro Glu  Pro Ser Ala Glu Asn  Gln Ser Thr Glu Gly  Thr Pro Glu 
    1670                 1675                 1680             


Gln Pro  Pro Leu Ile Thr Glu  Asp Glu Thr Arg Thr  Arg Thr Pro 
    1685                 1690                 1695             


Glu Pro  Ile Ile Ile Glu Glu  Glu Glu Glu Asp Ser  Ile Ser Leu 
    1700                 1705                 1710             


Leu Ser  Asp Gly Pro Thr His  Gln Val Leu Gln Val  Glu Ala Asp 
    1715                 1720                 1725             


Ile His  Gly Pro Pro Ser Val  Ser Ser Ser Ser Trp  Ser Ile Pro 
    1730                 1735                 1740             


His Ala  Ser Asp Phe Asp Val  Asp Ser Leu Ser Ile  Leu Asp Thr 
    1745                 1750                 1755             


Leu Glu  Gly Ala Ser Val Thr  Ser Gly Ala Thr Ser  Ala Glu Thr 
    1760                 1765                 1770             


Asn Ser  Tyr Phe Ala Lys Ser  Met Glu Phe Leu Ala  Arg Pro Val 
    1775                 1780                 1785             


Pro Ala  Pro Arg Thr Val Phe  Arg Asn Pro Pro His  Pro Ala Pro 
    1790                 1795                 1800             


Arg Thr  Arg Thr Pro Ser Leu  Ala Pro Ser Arg Ala  Cys Ser Arg 
    1805                 1810                 1815             


Thr Ser  Leu Val Ser Thr Pro  Pro Gly Val Asn Arg  Val Ile Thr 
    1820                 1825                 1830             


Arg Glu  Glu Leu Glu Ala Leu  Thr Pro Ser Arg Thr  Pro Ser Arg 
    1835                 1840                 1845             


Ser Val  Ser Arg Thr Ser Leu  Val Ser Asn Pro Pro  Gly Val Asn 
    1850                 1855                 1860             


Arg Val  Ile Thr Arg Glu Glu  Phe Glu Ala Phe Val  Ala Gln Gln 
    1865                 1870                 1875             


Gln Xaa  Arg Phe Asp Ala Gly  Ala Tyr Ile Phe Ser  Ser Asp Thr 
    1880                 1885                 1890             


Gly Gln  Gly His Leu Gln Gln  Lys Ser Val Arg Gln  Thr Val Leu 
    1895                 1900                 1905             


Ser Glu  Val Val Leu Glu Arg  Thr Glu Leu Glu Ile  Ser Tyr Ala 
    1910                 1915                 1920             


Pro Arg  Leu Asp Gln Glu Lys  Glu Glu Leu Leu Arg  Lys Lys Leu 
    1925                 1930                 1935             


Gln Leu  Asn Pro Thr Pro Ala  Asn Arg Ser Arg Tyr  Gln Ser Arg 
    1940                 1945                 1950             


Lys Val  Glu Asn Met Lys Ala  Ile Thr Ala Arg Arg  Ile Leu Gln 
    1955                 1960                 1965             


Gly Leu  Gly His Tyr Leu Lys  Ala Glu Gly Lys Val  Glu Cys Tyr 
    1970                 1975                 1980             


Arg Thr  Leu His Pro Val Pro  Leu Tyr Ser Ser Ser  Val Asn Arg 
    1985                 1990                 1995             


Ala Phe  Ser Ser Pro Lys Val  Ala Val Glu Ala Cys  Asn Ala Met 
    2000                 2005                 2010             


Leu Lys  Glu Asn Phe Pro Thr  Val Ala Ser Tyr Cys  Ile Ile Pro 
    2015                 2020                 2025             


Glu Tyr  Asp Ala Tyr Leu Asp  Met Val Asp Gly Ala  Ser Cys Cys 
    2030                 2035                 2040             


Leu Asp  Thr Ala Ser Phe Cys  Pro Ala Lys Leu Arg  Ser Phe Pro 
    2045                 2050                 2055             


Lys Lys  His Ser Tyr Leu Glu  Pro Thr Ile Arg Ser  Ala Val Pro 
    2060                 2065                 2070             


Ser Ala  Ile Gln Asn Thr Leu  Gln Asn Val Leu Ala  Ala Ala Thr 
    2075                 2080                 2085             


Lys Arg  Asn Cys Asn Val Thr  Gln Met Arg Glu Leu  Pro Val Leu 
    2090                 2095                 2100             


Asp Ser  Ala Ala Phe Asn Val  Glu Cys Phe Lys Lys  Tyr Ala Cys 
    2105                 2110                 2115             


Asn Asn  Glu Tyr Trp Glu Thr  Phe Lys Glu Asn Pro  Ile Arg Leu 
    2120                 2125                 2130             


Thr Glu  Glu Asn Val Val Asn  Tyr Ile Thr Lys Leu  Lys Gly Pro 
    2135                 2140                 2145             


Lys Ala  Ala Ala Leu Phe Ala  Lys Thr His Asn Leu  Asn Met Leu 
    2150                 2155                 2160             


Gln Asp  Ile Pro Met Asp Arg  Phe Val Met Asp Leu  Lys Arg Asp 
    2165                 2170                 2175             


Val Lys  Val Thr Pro Gly Thr  Lys His Thr Glu Glu  Arg Pro Lys 
    2180                 2185                 2190             


Val Gln  Val Ile Gln Ala Ala  Asp Pro Leu Ala Thr  Ala Tyr Leu 
    2195                 2200                 2205             


Cys Gly  Ile His Arg Glu Leu  Val Arg Arg Leu Asn  Ala Val Leu 
    2210                 2215                 2220             


Leu Pro  Asn Ile His Thr Leu  Phe Asp Met Ser Ala  Glu Asp Phe 
    2225                 2230                 2235             


Asp Ala  Ile Ile Ala Glu His  Phe Gln Pro Gly Asp  Cys Val Leu 
    2240                 2245                 2250             


Glu Thr  Asp Ile Ala Ser Phe  Asp Lys Ser Glu Asp  Asp Ala Met 
    2255                 2260                 2265             


Ala Leu  Thr Ala Leu Met Ile  Leu Glu Asp Leu Gly  Val Asp Ala 
    2270                 2275                 2280             


Glu Leu  Leu Thr Leu Ile Glu  Ala Ala Phe Gly Glu  Ile Ser Ser 
    2285                 2290                 2295             


Ile His  Leu Pro Thr Lys Thr  Lys Phe Lys Phe Gly  Ala Met Met 
    2300                 2305                 2310             


Lys Ser  Gly Met Phe Leu Thr  Leu Phe Val Asn Thr  Val Ile Asn 
    2315                 2320                 2325             


Ile Val  Ile Ala Ser Arg Val  Leu Arg Glu Arg Leu  Thr Gly Ser 
    2330                 2335                 2340             


Pro Cys  Ala Ala Phe Ile Gly  Asp Asp Asn Ile Val  Lys Gly Val 
    2345                 2350                 2355             


Lys Ser  Asp Lys Leu Met Ala  Asp Arg Cys Ala Thr  Trp Leu Asn 
    2360                 2365                 2370             


Met Glu  Val Lys Ile Ile Asp  Ala Val Val Gly Glu  Lys Ala Pro 
    2375                 2380                 2385             


Tyr Phe  Cys Gly Gly Phe Ile  Leu Cys Asp Ser Val  Thr Gly Thr 
    2390                 2395                 2400             


Ala Cys  Arg Val Ala Asp Pro  Leu Lys Arg Leu Phe  Lys Leu Gly 
    2405                 2410                 2415             


Lys Pro  Leu Ala Ala Asp Asp  Glu His Asp Asp Asp  Arg Arg Arg 
    2420                 2425                 2430             


Ala Leu  His Glu Glu Ser Thr  Arg Trp Asn Arg Val  Gly Ile Leu 
    2435                 2440                 2445             


Ser Glu  Leu Cys Lys Ala Val  Glu Ser Arg Tyr Glu  Thr Val Gly 
    2450                 2455                 2460             


Thr Ser  Ile Ile Val Met Ala  Met Thr Thr Leu Ala  Ser Ser Val 
    2465                 2470                 2475             


Lys Ser  Phe Ser Tyr Leu Arg  Gly Ala Pro Ile Thr  Leu Tyr Gly 
    2480                 2485                 2490             


Ser Gly  Glu Gly Arg Gly Ser  Leu Leu Thr Cys Gly  Asp Val Glu 
    2495                 2500                 2505             


Glu Asn  Pro Gly Pro Val Ser  Lys Gly Glu Glu Leu  Phe Thr Gly 
    2510                 2515                 2520             


Val Val  Pro Ile Leu Val Glu  Leu Asp Gly Asp Val  Asn Gly His 
    2525                 2530                 2535             


Lys Phe  Ser Val Ser Gly Glu  Gly Glu Gly Asp Ala  Thr Tyr Gly 
    2540                 2545                 2550             


Lys Leu  Thr Leu Lys Phe Ile  Cys Thr Thr Gly Lys  Leu Pro Val 
    2555                 2560                 2565             


Pro Trp  Pro Thr Leu Val Thr  Thr Leu Thr Tyr Gly  Val Gln Cys 
    2570                 2575                 2580             


Phe Ser  Arg Tyr Pro Asp His  Met Lys Gln His Asp  Phe Phe Lys 
    2585                 2590                 2595             


Ser Ala  Met Pro Glu Gly Tyr  Val Gln Glu Arg Thr  Ile Phe Phe 
    2600                 2605                 2610             


Lys Asp  Asp Gly Asn Tyr Lys  Thr Arg Ala Glu Val  Lys Phe Glu 
    2615                 2620                 2625             


Gly Asp  Thr Leu Val Asn Arg  Ile Glu Leu Lys Gly  Ile Asp Phe 
    2630                 2635                 2640             


Lys Glu  Asp Gly Asn Ile Leu  Gly His Lys Leu Glu  Tyr Asn Tyr 
    2645                 2650                 2655             


Asn Ser  His Asn Val Tyr Ile  Met Ala Asp Lys Gln  Lys Asn Gly 
    2660                 2665                 2670             


Ile Lys  Val Asn Phe Lys Ile  Arg His Asn Ile Glu  Asp Gly Ser 
    2675                 2680                 2685             


Val Gln  Leu Ala Asp His Tyr  Gln Gln Asn Thr Pro  Ile Gly Asp 
    2690                 2695                 2700             


Gly Pro  Val Leu Leu Pro Asp  Asn His Tyr Leu Ser  Thr Gln Ser 
    2705                 2710                 2715             


Lys Leu  Ser Lys Asp Pro Asn  Glu Lys Arg Asp His  Met Val Leu 
    2720                 2725                 2730             


Leu Glu  Phe Val Thr Ala Ala  Gly Ile Thr Leu Gly  Met Asp Glu 
    2735                 2740                 2745             


Leu Tyr  Lys 
    2750     


<210>  16
<211>  8256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C16 nsP-2A-eGFP coding sequence DNA

<400>  16
atggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttggaagtgc gcccgcccgc agaatgtatt ctaagcacaa gtatcattgt      240

atctgtccga tgagatgtgc ggaagatccg gacagattgt ataagtatgc aactaagctg      300

aagaaaaact gtaaggaaat aactgataag gaattggaca agaaaatgaa ggagctcgcc      360

gccgtcatga gcgaccctga cctggaaact gagactatgt gcctccacga cgacgagtcg      420

tgtcgctacg aagggcaagt cgctgtttac caggatgtat acgcggttga cggaccgaca      480

agtctctatc accaagccaa taagggagtt agagtcgcct actggatagg ctttgacacc      540

acccctttta tgtttaagaa cttggctgga gcatatccat catactctac caactgggcc      600

gacgaaaccg tgttaacggc tcgtaacata ggcctatgca gctctgacgt tatggagcgg      660

tcacgtagag ggatgtccat tcttagaaag aagtatttga aaccatccaa caatgttcta      720

ttctctgttg gctcgaccat ctaccacgag aagagggact tactgaggag ctggcacctg      780

ccgtctgtat ttcacttacg tggcaagcaa aattacacat gtcggtgtga gactatagtt      840

agttgcgacg ggtacgtcgt taaaagaata gctatcagtc caggcctgta tgggaagcct      900

tcaggctatg ctgctacgat gcaccgcgag ggattcttgt gctgcaaagt gacagacaca      960

ttgaacgggg agagggtctc ttttcccgtg tgcacgtatg tgccagctac attgtgtgac     1020

caaatgactg gcatactggc aacagatgtc agtgcggacg acgcgcaaaa actgctggtt     1080

gggctcaacc agcgtatagt cgtcaacggt cgcacccaga gaaacaccaa taccatgaaa     1140

aattaccttt tgcccgtagt ggcccaggca tttgctaggt gggcaaagga atataaggaa     1200

gatcaagaag atgaaaggcc actaggacta cgagatagac agttagtcat ggggtgttgt     1260

tgggctttta gaaggcacaa gataacatct atttataagc gcccggatac ccaaaccatc     1320

atcaaagtga acagcgattt ccactcattc gtgctgccca ggataggcag taacacattg     1380

gagatcgggc tgagaacaag aatcaggaaa atgttagagg agcacaagga gccgtcacct     1440

ctcattaccg ccgaggacgt acaagaagct aagtgcgcag ccgatgaggc taaggaggtg     1500

cgtgaagccg aggagttgcg cgcagctcta ccacctttgg cagctgatgt tgaggagccc     1560

actctggaag ccgatgtcga cttgatgtta caagaggctg gggccggctc agtggagaca     1620

cctcgtggct tgataaaggt taccagctac gctggcgagg acaagatcgg ctcttacgct     1680

gtgctttctc cgcaggctgt actcaagagt gaaaaattat cttgcatcca ccctctcgct     1740

gaacaagtca tagtgataac acactctggc cgaaaagggc gttatgccgt ggaaccatac     1800

catggtaaag tagtggtgcc agagggacat gcaatacccg tccaggactt tcaagctctg     1860

agtgaaagtg ccaccattgt gtacaacgaa cgtgagttcg taaacaggta cctgcaccat     1920

attgccacac atggaggagc gctgaacact gatgaagaat attacaaaac tgtcaagccc     1980

agcgagcacg acggcgaata cctgtacgac atcgacagga aacagtgcgt caagaaagaa     2040

ctagtcactg ggctagggct cacaggcgag ctggtggatc ctcccttcca tgaattcgcc     2100

tacgagagtc tgagaacacg accagccgct ccttaccaag taccaaccat aggggtgtat     2160

ggcgtgccag gatcaggcaa gtctggcatc attaaaagcg cagtcaccaa aaaagatcta     2220

gtggtgagcg ccaagaaaga aaactgtgca gaaattataa gggacgtcaa gaaaatgaaa     2280

gggctggacg tcaatgccag aactgtggac tcagtgctct tgaatggatg caaacacccc     2340

gtagagaccc tgtatattga cgaagctttt gcttgtcatg caggtactct cagagcgctc     2400

atagccatta taagacctaa aaaggcagtg ctctgcgggg atcccaaaca gtgcggtttt     2460

tttaacatga tgtgcctgaa agtgcatttt aaccacgaga tttgcacaca agtcttccac     2520

aaaagcatct ctcgccgttg cactaaatct gtgacttcgg tcgtctcaac cttgttttac     2580

gacaaaaaaa tgagaacgac gaatccgaaa gagactaaga ttgtgattga cactaccggc     2640

agtaccaaac ctaagcagga cgatctcatt ctcacttgtt tcagagggtg ggtgaagcag     2700

ttgcaaatag attacaaagg caacgaaata atgacggcag ctgcctctca agggctgacc     2760

cgtaaaggtg tgtatgccgt tcggtacaag gtgaatgaaa atcctctgta cgcacccacc     2820

tcagaacatg tgaacgtcct actgacccgc acggaggacc gcatcgtgtg gaaaacacta     2880

gccggcgacc catggataaa aacactgact gccaagtacc ctgggaattt cactgccacg     2940

atagaggagt ggcaagcaga gcatgatgcc atcatgaggc acatcttgga gagaccggac     3000

cctaccgacg tcttccagaa taaggcaaac gtgtgttggg ccaaggcttt agtgccggtg     3060

ctgaagaccg ctggcataga catgaccact gaacaatgga acactgtgga ttattttgaa     3120

acggacaaag ctcactcagc agagatagta ttgaaccaac tatgcgtgag gttctttgga     3180

ctcgatctgg actccggtct attttctgca cccactgttc cgttatccat taggaataat     3240

cactgggata actccccgtc gcctaacatg tacgggctga ataaagaagt ggtccgtcag     3300

ctctctcgca ggtacccaca actgcctcgg gcagttgcca ctggaagagt ctatgacatg     3360

aacactggta cactgcgcaa ttatgatccg cgcataaacc tagtacctgt aaacagaaga     3420

ctgcctcatg ctttagtcct ccaccataat gaacacccac agagtgactt ttcttcattc     3480

gtcagcaaat tgaagggcag aactgtcctg gtggtcgggg aaaagttgtc cgtcccaggc     3540

aaaatggttg actggttgtc agaccggcct gaggctacct tcagagctcg gctggattta     3600

ggcatcccag gtgatgtgcc caaatatgac ataatatttg ttaatgtgag gaccccatat     3660

aaataccatc actatcagca gtgtgaagac catgccatta agcttagcat gttgaccaag     3720

aaagcttgtc tgcatctgaa tcccggcgga acctgtgtca gcataggtta tggttacgct     3780

gacagggcca gcgaaagcat cattggtgct atagcgcggc agttcaagtt ttcccgggta     3840

tgcaaaccga aatcctcact tgaagagacg gaagttctgt ttgtattcat tgggtacgat     3900

cgcaaggccc gtacgcacaa tccttacaag ctttcatcaa ccttgaccaa catttataca     3960

ggttccagac tccacgaagc cggatgtgca ccctcatatc atgtggtgcg aggggatatt     4020

gccacggcca ccgaaggagt gattataaat gctgctaaca gcaaaggaca acctggcgga     4080

ggggtgtgcg gagcgctgta taagaaattc ccggaaagct tcgatttaca gccgatcgaa     4140

gtaggaaaag cgcgactggt caaaggtgca gctaaacata tcattcatgc cgtaggacca     4200

aacttcaaca aagtttcgga ggttgaaggt gacaaacagt tggcagaggc ttatgagtcc     4260

atcgctaaga ttgtcaacga taacaattac aagtcagtag cgattccact gttgtccacc     4320

ggcatctttt ccgggaacaa agatcgacta acccaatcat tgaaccattt gctgacagct     4380

ttagacacca ctgatgcaga tgtagccata tactgcaggg acaagaaatg ggaaatgact     4440

ctcaaggaag cagtggctag gagagaagca gtggaggaga tatgcatatc cgacgactct     4500

tcagtgacag aacctgatgc agagctggtg agggtgcatc cgaagagttc tttggctgga     4560

aggaagggct acagcacaag cgatggcaaa actttctcat atttggaagg gaccaagttt     4620

caccaggcgg ccaaggatat agcagaaatt aatgccatgt ggcccgttgc aacggaggcc     4680

aatgagcagg tatgcatgta tatcctcgga gaaagcatga gcagtattag gtcgaaatgc     4740

cccgtcgaag agtcggaagc ctccacacca cctagcacgc tgccttgctt gtgcatccat     4800

gccatgactc cagaaagagt acagcgccta aaagcctcac gtccagaaca aattactgtg     4860

tgctcatcct ttccattgcc gaagtataga atcactggtg tgcagaagat ccaatgctcc     4920

cagcctatat tgttctcacc gaaagtgcct gcgtatattc atccaaggaa gtatctcgtg     4980

gaaacaccac cggtagacga gactccggag ccatcggcag agaaccaatc cacagagggg     5040

acacctgaac aaccaccact tataaccgag gatgagacca ggactagaac gcctgagccg     5100

atcatcatcg aagaggaaga agaggatagc ataagtttgc tgtcagatgg cccgacccac     5160

caggtgctgc aagtcgaggc agacattcac gggccgccct ctgtatctag ctcatcctgg     5220

tccattcctc atgcatccga ctttgatgtg gacagtttat ccatacttga caccctggag     5280

ggagctagcg tgaccagcgg ggcaacgtca gccgagacta actcttactt cgcaaagagt     5340

atggagtttc tggcgcgacc ggtgcctgcg cctcgaacag tattcaggaa ccctccacat     5400

cccgctccgc gcacaagaac accgtcactt gcacccagca gggcctgctc gagaaccagc     5460

ctagtttcca ccccgccagg cgtgaatagg gtgatcacta gagaggagct cgaggcgctt     5520

accccgtcac gcactcctag caggtcggtc tcgagaacca gcctggtctc caacccgcca     5580

ggcgtaaata gggtgattac aagagaggag tttgaggcgt tcgtagcaca acaacaatga     5640

cggtttgatg cgggtgcata catcttttcc tccgacaccg gtcaagggca tttacaacaa     5700

aaatcagtaa ggcaaacggt gctatccgaa gtggtgttgg agaggaccga attggagatt     5760

tcgtatgccc cgcgcctcga ccaagaaaaa gaagaattac tacgcaagaa attacagtta     5820

aatcccacac ctgctaacag aagcagatac cagtccagga aggtggagaa catgaaagcc     5880

ataacagcta gacgtattct gcaaggccta gggcattatt tgaaggcaga aggaaaagtg     5940

gagtgctacc gaaccctgca tcctgttcct ttgtattcat ctagtgtgaa ccgtgccttt     6000

tcaagcccca aggtcgcagt ggaagcctgt aacgccatgt tgaaagagaa ctttccgact     6060

gtggcttctt actgtattat tccagagtac gatgcctatt tggacatggt tgacggagct     6120

tcatgctgct tagacactgc cagtttttgc cctgcaaagc tgcgcagctt tccaaagaaa     6180

cactcctatt tggaacccac aatacgatcg gcagtgcctt cagcgatcca gaacacgctc     6240

cagaacgtcc tggcagctgc cacaaaaaga aattgcaatg tcacgcaaat gagagaattg     6300

cccgtattgg attcggcggc ctttaatgtg gaatgcttca agaaatatgc gtgtaataat     6360

gaatattggg aaacgtttaa agaaaacccc atcaggctta ctgaagaaaa cgtggtaaat     6420

tacattacca aattaaaagg accaaaagct gctgctcttt ttgcgaagac acataatttg     6480

aatatgttgc aggacatacc aatggacagg tttgtaatgg acttaaagag agacgtgaaa     6540

gtgactccag gaacaaaaca tactgaagaa cggcccaagg tacaggtgat ccaggctgcc     6600

gatccgctag caacagcgta tctgtgcgga atccaccgag agctggttag gagattaaat     6660

gcggtcctgc ttccgaacat tcatacactg tttgatatgt cggctgaaga ctttgacgct     6720

attatagccg agcacttcca gcctggggat tgtgttctgg aaactgacat cgcgtcgttt     6780

gataaaagtg aggacgacgc catggctctg accgcgttaa tgattctgga agacttaggt     6840

gtggacgcag agctgttgac gctgattgag gcggctttcg gcgaaatttc atcaatacat     6900

ttgcccacta aaactaaatt taagttcggc gccatgatga agtccggcat gtttctgacc     6960

ctgttcgtga acaccgtgat caacatcgtg atcgccagcc gggtgctgag agagagactg     7020

acaggatctc cttgcgccgc cttcatcggc gacgacaata tcgtgaaggg cgtgaagtcc     7080

gacaagctga tggccgatag atgcgccacc tggctgaaca tggaagtgaa gatcatcgac     7140

gccgtcgtgg gcgagaaggc cccttatttt tgcggcggct tcatcctgtg cgacagcgtg     7200

acaggcacag cctgcagagt tgccgatcct ctgaagcggc tgttcaagct gggaaaacct     7260

ctggccgccg acgacgagca cgacgacgat agacgtagag ccctgcacga ggaatccacc     7320

agatggaaca gagtgggcat cctgagcgag ctgtgcaagg ccgtggaaag cagatacgag     7380

acagtgggca ccagcatcat tgtgatggca atgaccacac tggccagcag cgtgaaaagc     7440

ttcagctacc taaggggcgc ccctatcaca ctgtacggct ctggcgaagg cagaggcagc     7500

cttctgacat gtggcgacgt ggaagagaac cccggacctg tgtctaaggg cgaagaactg     7560

tttaccggcg tggtgcccat cctggtggaa ctggatgggg atgtgaacgg ccacaagttc     7620

agcgttagcg gagaaggcga aggcgacgcc acatacggaa agctgaccct gaagttcatc     7680

tgcaccaccg gcaagctgcc tgtgccatgg cctacactgg tcaccacact gacatacggc     7740

gtgcagtgct tcagcagata ccccgaccat atgaagcagc acgacttctt caagagcgcc     7800

atgcctgagg gctacgtgca agagcggacc atcttcttta aggacgacgg caactacaag     7860

accagggccg aagtgaagtt cgagggcgac accctggtca accggatcga gctgaagggc     7920

atcgacttca aagaggacgg caatatcctg ggccacaagc tcgagtacaa ctacaacagc     7980

cacaacgtgt acatcatggc cgacaagcag aaaaacggca tcaaagtgaa cttcaagatc     8040

cggcacaaca tcgaggacgg ctctgtgcag ctggccgatc actaccagca gaacacaccc     8100

atcggagatg gccctgtgct gctgcccgat aaccactacc tgagcaccca gagcaagctg     8160

agcaaggacc ccaacgagaa gcgggaccac atggtgctgc tggaatttgt gacagccgcc     8220

ggaatcaccc tcggcatgga tgagctgtac aagtga                               8256


<210>  17
<211>  11447
<212>  DNA
<213>  Venezuelan equine encephalitis virus


<220>
<221>  misc_feature
<222>  (1)..(11447)
<223>  VEEV genome L01442.2

<400>  17
atgggcggcg catgagagaa gcccagacca attacctacc caaaatggag aaagttcacg       60

ttgacatcga ggaagacagc ccattcctca gagctttgca gcggagcttc ccgcagtttg      120

aggtagaagc caagcaggtc actgataatg accatgctaa tgccagagcg ttttcgcatc      180

tggcttcaaa actgatcgaa acggaggtgg acccatccga cacgatcctt gacattggaa      240

gtgcgcccgc ccgcagaatg tattctaagc acaagtatca ttgtatctgt ccgatgagat      300

gtgcggaaga tccggacaga ttgtataagt atgcaactaa gctgaagaaa aactgtaagg      360

aaataactga taaggaattg gacaagaaaa tgaaggagct cgccgccgtc atgagcgacc      420

ctgacctgga aactgagact atgtgcctcc acgacgacga gtcgtgtcgc tacgaagggc      480

aagtcgctgt ttaccaggat gtatacgcgg ttgacggacc gacaagtctc tatcaccaag      540

ccaataaggg agttagagtc gcctactgga taggctttga caccacccct tttatgttta      600

agaacttggc tggagcatat ccatcatact ctaccaactg ggccgacgaa accgtgttaa      660

cggctcgtaa cataggccta tgcagctctg acgttatgga gcggtcacgt agagggatgt      720

ccattcttag aaagaagtat ttgaaaccat ccaacaatgt tctattctct gttggctcga      780

ccatctacca cgagaagagg gacttactga ggagctggca cctgccgtct gtatttcact      840

tacgtggcaa gcaaaattac acatgtcggt gtgagactat agttagttgc gacgggtacg      900

tcgttaaaag aatagctatc agtccaggcc tgtatgggaa gccttcaggc tatgctgcta      960

cgatgcaccg cgagggattc ttgtgctgca aagtgacaga cacattgaac ggggagaggg     1020

tctcttttcc cgtgtgcacg tatgtgccag ctacattgtg tgaccaaatg actggcatac     1080

tggcaacaga tgtcagtgcg gacgacgcgc aaaaactgct ggttgggctc aaccagcgta     1140

tagtcgtcaa cggtcgcacc cagagaaaca ccaataccat gaaaaattac cttttgcccg     1200

tagtggccca ggcatttgct aggtgggcaa aggaatataa ggaagatcaa gaagatgaaa     1260

ggccactagg actacgagat agacagttag tcatggggtg ttgttgggct tttagaaggc     1320

acaagataac atctatttat aagcgcccgg atacccaaac catcatcaaa gtgaacagcg     1380

atttccactc attcgtgctg cccaggatag gcagtaacac attggagatc gggctgagaa     1440

caagaatcag gaaaatgtta gaggagcaca aggagccgtc acctctcatt accgccgagg     1500

acgtacaaga agctaagtgc gcagccgatg aggctaagga ggtgcgtgaa gccgaggagt     1560

tgcgcgcagc tctaccacct ttggcagctg atgttgagga gcccactctg gaagccgatg     1620

tcgacttgat gttacaagag gctggggccg gctcagtgga gacacctcgt ggcttgataa     1680

aggttaccag ctacgctggc gaggacaaga tcggctctta cgctgtgctt tctccgcagg     1740

ctgtactcaa gagtgaaaaa ttatcttgca tccaccctct cgctgaacaa gtcatagtga     1800

taacacactc tggccgaaaa gggcgttatg ccgtggaacc ataccatggt aaagtagtgg     1860

tgccagaggg acatgcaata cccgtccagg actttcaagc tctgagtgaa agtgccacca     1920

ttgtgtacaa cgaacgtgag ttcgtaaaca ggtacctgca ccatattgcc acacatggag     1980

gagcgctgaa cactgatgaa gaatattaca aaactgtcaa gcccagcgag cacgacggcg     2040

aatacctgta cgacatcgac aggaaacagt gcgtcaagaa agaactagtc actgggctag     2100

ggctcacagg cgagctggtg gatcctccct tccatgaatt cgcctacgag agtctgagaa     2160

cacgaccagc cgctccttac caagtaccaa ccataggggt gtatggcgtg ccaggatcag     2220

gcaagtctgg catcattaaa agcgcagtca ccaaaaaaga tctagtggtg agcgccaaga     2280

aagaaaactg tgcagaaatt ataagggacg tcaagaaaat gaaagggctg gacgtcaatg     2340

ccagaactgt ggactcagtg ctcttgaatg gatgcaaaca ccccgtagag accctgtata     2400

ttgacgaagc ttttgcttgt catgcaggta ctctcagagc gctcatagcc attataagac     2460

ctaaaaaggc agtgctctgc ggggatccca aacagtgcgg tttttttaac atgatgtgcc     2520

tgaaagtgca ttttaaccac gagatttgca cacaagtctt ccacaaaagc atctctcgcc     2580

gttgcactaa atctgtgact tcggtcgtct caaccttgtt ttacgacaaa aaaatgagaa     2640

cgacgaatcc gaaagagact aagattgtga ttgacactac cggcagtacc aaacctaagc     2700

aggacgatct cattctcact tgtttcagag ggtgggtgaa gcagttgcaa atagattaca     2760

aaggcaacga aataatgacg gcagctgcct ctcaagggct gacccgtaaa ggtgtgtatg     2820

ccgttcggta caaggtgaat gaaaatcctc tgtacgcacc cacctcagaa catgtgaacg     2880

tcctactgac ccgcacggag gaccgcatcg tgtggaaaac actagccggc gacccatgga     2940

taaaaacact gactgccaag taccctggga atttcactgc cacgatagag gagtggcaag     3000

cagagcatga tgccatcatg aggcacatct tggagagacc ggaccctacc gacgtcttcc     3060

agaataaggc aaacgtgtgt tgggccaagg ctttagtgcc ggtgctgaag accgctggca     3120

tagacatgac cactgaacaa tggaacactg tggattattt tgaaacggac aaagctcact     3180

cagcagagat agtattgaac caactatgcg tgaggttctt tggactcgat ctggactccg     3240

gtctattttc tgcacccact gttccgttat ccattaggaa taatcactgg gataactccc     3300

cgtcgcctaa catgtacggg ctgaataaag aagtggtccg tcagctctct cgcaggtacc     3360

cacaactgcc tcgggcagtt gccactggaa gagtctatga catgaacact ggtacactgc     3420

gcaattatga tccgcgcata aacctagtac ctgtaaacag aagactgcct catgctttag     3480

tcctccacca taatgaacac ccacagagtg acttttcttc attcgtcagc aaattgaagg     3540

gcagaactgt cctggtggtc ggggaaaagt tgtccgtccc aggcaaaatg gttgactggt     3600

tgtcagaccg gcctgaggct accttcagag ctcggctgga tttaggcatc ccaggtgatg     3660

tgcccaaata tgacataata tttgttaatg tgaggacccc atataaatac catcactatc     3720

agcagtgtga agaccatgcc attaagctta gcatgttgac caagaaagct tgtctgcatc     3780

tgaatcccgg cggaacctgt gtcagcatag gttatggtta cgctgacagg gccagcgaaa     3840

gcatcattgg tgctatagcg cggcagttca agttttcccg ggtatgcaaa ccgaaatcct     3900

cacttgaaga gacggaagtt ctgtttgtat tcattgggta cgatcgcaag gcccgtacgc     3960

acaatcctta caagctttca tcaaccttga ccaacattta tacaggttcc agactccacg     4020

aagccggatg tgcaccctca tatcatgtgg tgcgagggga tattgccacg gccaccgaag     4080

gagtgattat aaatgctgct aacagcaaag gacaacctgg cggaggggtg tgcggagcgc     4140

tgtataagaa attcccggaa agcttcgatt tacagccgat cgaagtagga aaagcgcgac     4200

tggtcaaagg tgcagctaaa catatcattc atgccgtagg accaaacttc aacaaagttt     4260

cggaggttga aggtgacaaa cagttggcag aggcttatga gtccatcgct aagattgtca     4320

acgataacaa ttacaagtca gtagcgattc cactgttgtc caccggcatc ttttccggga     4380

acaaagatcg actaacccaa tcattgaacc atttgctgac agctttagac accactgatg     4440

cagatgtagc catatactgc agggacaaga aatgggaaat gactctcaag gaagcagtgg     4500

ctaggagaga agcagtggag gagatatgca tatccgacga ctcttcagtg acagaacctg     4560

atgcagagct ggtgagggtg catccgaaga gttctttggc tggaaggaag ggctacagca     4620

caagcgatgg caaaactttc tcatatttgg aagggaccaa gtttcaccag gcggccaagg     4680

atatagcaga aattaatgcc atgtggcccg ttgcaacgga ggccaatgag caggtatgca     4740

tgtatatcct cggagaaagc atgagcagta ttaggtcgaa atgccccgtc gaagagtcgg     4800

aagcctccac accacctagc acgctgcctt gcttgtgcat ccatgccatg actccagaaa     4860

gagtacagcg cctaaaagcc tcacgtccag aacaaattac tgtgtgctca tcctttccat     4920

tgccgaagta tagaatcact ggtgtgcaga agatccaatg ctcccagcct atattgttct     4980

caccgaaagt gcctgcgtat attcatccaa ggaagtatct cgtggaaaca ccaccggtag     5040

acgagactcc ggagccatcg gcagagaacc aatccacaga ggggacacct gaacaaccac     5100

cacttataac cgaggatgag accaggacta gaacgcctga gccgatcatc atcgaagagg     5160

aagaagagga tagcataagt ttgctgtcag atggcccgac ccaccaggtg ctgcaagtcg     5220

aggcagacat tcacgggccg ccctctgtat ctagctcatc ctggtccatt cctcatgcat     5280

ccgactttga tgtggacagt ttatccatac ttgacaccct ggagggagct agcgtgacca     5340

gcggggcaac gtcagccgag actaactctt acttcgcaaa gagtatggag tttctggcgc     5400

gaccggtgcc tgcgcctcga acagtattca ggaaccctcc acatcccgct ccgcgcacaa     5460

gaacaccgtc acttgcaccc agcagggcct gctcgagaac cagcctagtt tccaccccgc     5520

caggcgtgaa tagggtgatc actagagagg agctcgaggc gcttaccccg tcacgcactc     5580

ctagcaggtc ggtctcgaga accagcctgg tctccaaccc gccaggcgta aatagggtga     5640

ttacaagaga ggagtttgag gcgttcgtag cacaacaaca atgacggttt gatgcgggtg     5700

catacatctt ttcctccgac accggtcaag ggcatttaca acaaaaatca gtaaggcaaa     5760

cggtgctatc cgaagtggtg ttggagagga ccgaattgga gatttcgtat gccccgcgcc     5820

tcgaccaaga aaaagaagaa ttactacgca agaaattaca gttaaatccc acacctgcta     5880

acagaagcag ataccagtcc aggaaggtgg agaacatgaa agccataaca gctagacgta     5940

ttctgcaagg cctagggcat tatttgaagg cagaaggaaa agtggagtgc taccgaaccc     6000

tgcatcctgt tcctttgtat tcatctagtg tgaaccgtgc cttttcaagc cccaaggtcg     6060

cagtggaagc ctgtaacgcc atgttgaaag agaactttcc gactgtggct tcttactgta     6120

ttattccaga gtacgatgcc tatttggaca tggttgacgg agcttcatgc tgcttagaca     6180

ctgccagttt ttgccctgca aagctgcgca gctttccaaa gaaacactcc tatttggaac     6240

ccacaatacg atcggcagtg ccttcagcga tccagaacac gctccagaac gtcctggcag     6300

ctgccacaaa aagaaattgc aatgtcacgc aaatgagaga attgcccgta ttggattcgg     6360

cggcctttaa tgtggaatgc ttcaagaaat atgcgtgtaa taatgaatat tgggaaacgt     6420

ttaaagaaaa ccccatcagg cttactgaag aaaacgtggt aaattacatt accaaattaa     6480

aaggaccaaa agctgctgct ctttttgcga agacacataa tttgaatatg ttgcaggaca     6540

taccaatgga caggtttgta atggacttaa agagagacgt gaaagtgact ccaggaacaa     6600

aacatactga agaacggccc aaggtacagg tgatccaggc tgccgatccg ctagcaacag     6660

cgtatctgtg cggaatccac cgagagctgg ttaggagatt aaatgcggtc ctgcttccga     6720

acattcatac actgtttgat atgtcggctg aagactttga cgctattata gccgagcact     6780

tccagcctgg ggattgtgtt ctggaaactg acatcgcgtc gtttgataaa agtgaggacg     6840

acgccatggc tctgaccgcg ttaatgattc tggaagactt aggtgtggac gcagagctgt     6900

tgacgctgat tgaggcggct ttcggcgaaa tttcatcaat acatttgccc actaaaacta     6960

aatttaaatt cggagccatg atgaaatctg gaatgttcct cacactgttt gtgaacacag     7020

tcattaacat tgtaatcgca agcagagtgt tgagagaacg gctaaccgga tcaccatgtg     7080

cagcattcat tggagatgac aatatcgtga aaggagtcaa atcggacaaa ttaatggcag     7140

acaggtgcgc cacctggttg aatatggaag tcaagattat agatgctgtg gtgggcgaga     7200

aagcgcctta tttctgtgga gggtttattt tgtgtgactc cgtgaccggc acagcgtgcc     7260

gtgtggcaga ccccctaaaa aggctgttta agcttggcaa acctctggca gcagacgatg     7320

aacatgatga tgacaggaga agggcattgc atgaagagtc aacacgctgg aaccgagtgg     7380

gtattctttc agagctgtgc aaggcagtag aatcaaggta tgaaaccgta ggaacttcca     7440

tcatagttat ggccatgact actctagcta gcagtgttaa atcattcagc tacctgagag     7500

gggcccctat aactctctac ggctaacctg aatggactac gacatagtct agtccgccaa     7560

gatgttcccg ttccagccaa tgtatccgat gcagccaatg ccctatcgca acccgttcgc     7620

ggccccgcgc aggccctggt tccccagaac cgaccctttt ctggcgatgc aggtgcagga     7680

attaacccgc tcgatggcta acctgacgtt caagcaacgc cgggacgcgc cacctgaggg     7740

gccatccgct aagaaaccga agaaggaggc ctcgcaaaaa cagaaagggg gaggccaagg     7800

gaagaagaag aagaaccaag ggaagaagaa ggctaagaca gggccgccta atccgaaggc     7860

acagaatgga aacaagaaga agaccaacaa gaaaccaggc aagagacagc gcatggtcat     7920

gaaattggaa tctgacaaga cgttcccaat catgttggaa gggaagataa acggctacgc     7980

ttgtgtggtc ggagggaagt tattcaggcc gatgcatgtg gaaggcaaga tcgacaacga     8040

cgttctggcc gcgcttaaga cgaagaaagc atccaaatac gatcttgagt atgcagatgt     8100

gccacagaac atgcgggccg atacattcaa atacacccat gagaaacccc aaggctatta     8160

cagctggcat catggagcag tccaatatga aaatgggcgt ttcacggtgc cgaaaggagt     8220

tggggccaag ggagacagcg gacgacccat tctggataac cagggacggg tggtcgctat     8280

tgtgctggga ggtgtgaatg aaggatctag gacagccctt tcagtcgtca tgtggaacga     8340

gaagggagtt accgtgaagt atactccgga gaactgcgag caatggtcac tagtgaccac     8400

catgtgtctg ctcgccaatg tgacgttccc atgtgctcaa ccaccaattt gctacgacag     8460

aaaaccagca gagactttgg ccatgctcag cgttaacgtt gacaacccgg gctacgatga     8520

gctgctggaa gcagctgtta agtgccccgg aaggaaaagg agatccaccg aggagctgtt     8580

taaggagtat aagctaacgc gcccttacat ggccagatgc atcagatgtg cagttgggag     8640

ctgccatagt ccaatagcaa tcgaggcagt aaagagcgac gggcacgacg gttatgttag     8700

acttcagact tcctcgcagt atggcctgga ttcctccggc aacttaaagg gcaggaccat     8760

gcggtatgac atgcacggga ccattaaaga gataccacta catcaagtgt cactccatac     8820

atctcgcccg tgtcacattg tggatgggca cggttatttc ctgcttgcca ggtgcccggc     8880

aggggactcc atcaccatgg aatttaagaa agattccgtc acacactcct gctcggtgcc     8940

gtatgaagtg aaatttaatc ctgtaggcag agaactctat actcatcccc cagaacacgg     9000

agtagagcaa gcgtgccaag tctacgcaca tgatgcacag aacagaggag cttatgtcga     9060

gatgcacctc ccgggctcag aagtggacag cagtttggtt tccttgagcg gcagttcagt     9120

caccgtgaca cctcctgttg ggactagcgc cctggtggaa tgcgagtgtg gcggcacaaa     9180

gatctccgag accatcaaca agacaaaaca gttcagccag tgcacaaaga aggagcagtg     9240

cagagcatat cggctgcaga acgataagtg ggtgtataat tctgacaaac tgcccaaagc     9300

agcgggagcc accttaaaag gaaaactgca tgtcccattc ttgctggcag acggcaaatg     9360

caccgtgcct ctagcaccag aacctatgat aacctttggt ttcagatcag tgtcactgaa     9420

actgcaccct aagaatccca catatctaac cacccgccaa cttgctgatg agcctcacta     9480

cacgcacgag ctcatatctg aaccagctgt taggaatttt accgtcaccg aaaaagggtg     9540

ggagtttgta tggggaaacc acccgccgaa aaggttttgg gcacaggaaa cagcacccgg     9600

aaatccacat gggctaccgc acgaggtgat aactcattat taccacagat accctatgtc     9660

caccatcctg ggtttgtcaa tttgtgccgc cattgcaacc gtttccgttg cagcgtctac     9720

ctggctgttt tgcagatcta gagttgcgtg cctaactcct taccggctaa cacctaacgc     9780

taggatacca ttttgtctgg ctgtgctttg ctgcgcccgc actgcccggg ccgagaccac     9840

ctgggagtcc ttggatcacc tatggaacaa taaccaacag atgttctgga ttcaattgct     9900

gatccctctg gccgccttga tcgtagtgac tcgcctgctc aggtgcgtgt gctgtgtcgt     9960

gcctttttta gtcatggccg gcgccgcagg cgccggcgcc tacgagcacg cgaccacgat    10020

gccgagccaa gcgggaatct cgtataacac tatagtcaac agagcaggct acgcaccact    10080

ccctatcagc ataacaccaa caaagatcaa gctgatacct acagtgaact tggagtacgt    10140

cacctgccac tacaaaacag gaatggattc accagccatc aaatgctgcg gatctcagga    10200

atgcactcca acttacaggc ctgatgaaca gtgcaaagtc ttcacagggg tttacccgtt    10260

catgtggggt ggtgcatatt gcttttgcga cactgagaac acccaagtca gcaaggccta    10320

cgtaatgaaa tctgacgact gccttgcgga tcatgctgaa gcatataaag cgcacacagc    10380

ctcagtgcag gcgttcctca acatcacagt gggagaacac tctattgtga ctaccgtgta    10440

tgtgaatgga gaaactcctg tgaatttcaa tggggtcaaa ttaactgcag gtccgctttc    10500

cacagcttgg acaccctttg atcgcaaaat cgtgcagtat gccggggaga tctataatta    10560

tgattttcct gagtatgggg caggacaacc aggagcattt ggagatatac aatccagaac    10620

agtctcaagc tcagatctgt atgccaatac caacctagtg ctgcagagac ccaaagcagg    10680

agcgatccac gtgccataca ctcaggcacc ttcgggtttt gagcaatgga agaaagataa    10740

agctccatca ttgaaattta ccgccccttt cggatgcgaa atatatacaa accccattcg    10800

cgccgaaaac tgtgctgtag ggtcaattcc attagccttt gacattcccg acgccttgtt    10860

caccagggtg tcagaaacac cgacactttc agcggccgaa tgcactctta acgagtgcgt    10920

gtattcttcc gactttggtg ggatcgccac ggtcaagtac tcggccagca agtcaggcaa    10980

gtgcgcagtc catgtgccat cagggactgc taccctaaaa gaagcagcag tcgagctaac    11040

cgagcaaggg tcggcgacta tccatttctc gaccgcaaat atccacccgg agttcaggct    11100

ccaaatatgc acatcatatg ttacgtgcaa aggtgattgt caccccccga aagaccatat    11160

tgtgacacac cctcagtatc acgcccaaac atttacagcc gcggtgtcaa aaaccgcgtg    11220

gacgtggtta acatccctgc tgggaggatc agccgtaatt attataattg gcttggtgct    11280

ggctactatt gtggccatgt acgtgctgac caaccagaaa cataattgaa tacagcagca    11340

attggcaagc tgcttacata gaactcgcgg cgattggcat gccgccttaa aatttttatt    11400

ttattttttc ttttcttttc cgaatcggat tttgttttta atatttc                  11447


<210>  18
<211>  558
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, VEEV rep RNA nt 6966-7523 with silent 
       mutations

<400>  18
aaguucggcg ccaugaugaa guccggcaug uuucugaccc uguucgugaa caccgugauc       60

aacaucguga ucgccagccg ggugcugaga gagagacuga caggaucucc uugcgccgcc      120

uucaucggcg acgacaauau cgugaagggc gugaaguccg acaagcugau ggccgauaga      180

ugcgccaccu ggcugaacau ggaagugaag aucaucgacg ccgucguggg cgagaaggcc      240

ccuuauuuuu gcggcggcuu cauccugugc gacagcguga caggcacagc cugcagaguu      300

gccgauccuc ugaagcggcu guucaagcug ggaaaaccuc uggccgccga cgacgagcac      360

gacgacgaua gacguagagc ccugcacgag gaauccacca gauggaacag agugggcauc      420

cugagcgagc ugugcaaggc cguggaaagc agauacgaga cagugggcac cagcaucauu      480

gugauggcaa ugaccacacu ggccagcagc gugaaaagcu ucagcuaccu aaggggcgcc      540

ccuaucacac uguacggc                                                    558


<210>  19
<211>  1821
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, RNA nsP4 engineered RNA +silent mutations

<400>  19
uacaucuuuu ccuccgacac cggucaaggg cauuuacaac aaaaaucagu aaggcaaacg       60

gugcuauccg aagugguguu ggagaggacc gaauuggaga uuucguaugc cccgcgccuc      120

gaccaagaaa aagaagaauu acuacgcaag aaauuacagu uaaaucccac accugcuaac      180

agaagcagau accaguccag gaagguggag aacaugaaag ccauaacagc uagacguauu      240

cugcaaggcc uagggcauua uuugaaggca gaaggaaaag uggagugcua ccgaacccug      300

cauccuguuc cuuuguauuc aucuagugug aaccgugccu uuucaagccc caaggucgca      360

guggaagccu guaacgccau guugaaagag aacuuuccga cuguggcuuc uuacuguauu      420

auuccagagu acgaugccua uuuggacaug guugacggag cuucaugcug cuuagacacu      480

gccaguuuuu gcccugcaaa gcugcgcagc uuuccaaaga aacacuccua uuuggaaccc      540

acaauacgau cggcagugcc uucagcgauc cagaacacgc uccagaacgu ccuggcagcu      600

gccacaaaaa gaaauugcaa ugucacgcaa augagagaau ugcccguauu ggauucggcg      660

gccuuuaaug uggaaugcuu caagaaauau gcguguaaua augaauauug ggaaacguuu      720

aaagaaaacc ccaucaggcu uacugaagaa aacgugguaa auuacauuac caaauuaaaa      780

ggaccaaaag cugcugcucu uuuugcgaag acacauaauu ugaauauguu gcaggacaua      840

ccaauggaca gguuuguaau ggacuuaaag agagacguga aagugacucc aggaacaaaa      900

cauacugaag aacggcccaa gguacaggug auccaggcug ccgauccgcu agcaacagcg      960

uaucugugcg gaauccaccg agagcugguu aggagauuaa augcgguccu gcuuccgaac     1020

auucauacac uguuugauau gucggcugaa gacuuugacg cuauuauagc cgagcacuuc     1080

cagccugggg auuguguucu ggaaacugac aucgcgucgu uugauaaaag ugaggacgac     1140

gccauggcuc ugaccgcguu aaugauucug gaagacuuag guguggacgc agagcuguug     1200

acgcugauug aggcggcuuu cggcgaaauu ucaucaauac auuugcccac uaaaacuaaa     1260

uuuaaguucg gcgccaugau gaaguccggc auguuucuga cccuguucgu gaacaccgug     1320

aucaacaucg ugaucgccag ccgggugcug agagagagac ugacaggauc uccuugcgcc     1380

gccuucaucg gcgacgacaa uaucgugaag ggcgugaagu ccgacaagcu gauggccgau     1440

agaugcgcca ccuggcugaa cauggaagug aagaucaucg acgccgucgu gggcgagaag     1500

gccccuuauu uuugcggcgg cuucauccug ugcgacagcg ugacaggcac agccugcaga     1560

guugccgauc cucugaagcg gcuguucaag cugggaaaac cucuggccgc cgacgacgag     1620

cacgacgacg auagacguag agcccugcac gaggaaucca ccagauggaa cagagugggc     1680

auccugagcg agcugugcaa ggccguggaa agcagauacg agacaguggg caccagcauc     1740

auugugaugg caaugaccac acuggccagc agcgugaaaa gcuucagcua ccuaaggggc     1800

gccccuauca cacuguacgg c                                               1821


<210>  20
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C01 nsP1-4 ORF and SGP RNA

<400>  20
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaagu acgccugcaa caacgaguac ugggagacau     6420

ucaaagagaa ccccauccgg cugaccgagg aaaacguggu caacuacauc accaagcuga     6480

agggccccaa agccgccgcu cuguuugcca agacacacaa ccugaacaug cugcaggaca     6540

uccccaugga cagauucgug auggaccuga agcgggacgu gaaagugacc ccuggcacca     6600

agcacaccga ggaacggccu aaggugcaag ugauccaggc cgcugauccu cuggccacag     6660

ccuaucugug uggcauccac agagaacucg ugcggagacu gaaugccgug cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg cugaugauuc uggaagaucu cggaguggac gccgagcugc     6900

ugacacugau ugaagccgcc uuuggcgaga ucagcagcau ccaucugccu accaagacca     6960

aguucaaguu cggcgccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaacaggc agcccuugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  21
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C02 nsP1-4 ORF and SGP RNA

<400>  21
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauaugccg uggauggccc uacaagccug uaccaccagg      540

ccaacaaggg cgucagagug gccuacugga ucggcuucga caccacaccu uucauguuca      600

agaaccuggc uggcgcuuac cccagcuaca gcacaaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  22
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C03 nsP1-4 ORF and SGP RNA

<400>  22
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc cuacaaguac caccacuacc     3720

agcagugcga ggaccacgcc aucaagcuga gcaugcugac caagaaggcc ugccugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucaucggcua cgacagaaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  23
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C04 nsP1-4 ORF and SGP RNA

<400>  23
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaaccccua caagcugagc agcacccuga ccaacaucua caccggcagc agacugcacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccaca gccacagaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  24
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C05 nsP1-4 ORF and SGP RNA

<400>  24
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagcgagaag cugagcugca uucacccucu ggccgagcaa gugaucguga     1800

ucacacacag cggccggaag ggcagauaug ccguggaacc uuaucacggc aagguggugg     1860

ugccugaggg acacgcuauu ccagugcagg acuuucaggc ccugagcgag ucugccacca     1920

ucguguacaa cgagcgcgag uucgugaaca gauaccugca ccacauugcc acacacggcg     1980

gagcccugaa caccgacgaa gaguacuaca agaccgugaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggauagcgug cugcugaacg gcugcaagca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccua agcagugcgg cuucuucaac augaugugcc     2520

ugaaggugca cuucaaccac gagaucugca cccagguguu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  25
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C06 nsP1-4 ORF and SGP RNA

<400>  25
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggccagaaa uaucggccug uguagcagcg acgugaugga aagauccaga cggggcauga      720

gcauccugcg gaagaaguac cugaagccua gcaacaacgu gcuguucagc gugggcagca      780

ccaucuacca cgagaagagg gaccugcugc ggagcuggca ucugccuucc guguuucacc      840

ugagaggcaa gcagaacuac accuguagau gcgagacaau cguguccugc gacggcuacg      900

uggucaagcg gaucgccauu ucuccuggcc uguacggcaa gccuucuggc uaugccgcca      960

ccaugcacag agaaggcuuu cuguguugca aagugaccga cacacugaac ggcgagcggg     1020

uguccuuucc uguguguacc uaugugcccg ccacacugug cgaucagaug acaggcauuc     1080

uggccaccga cgugucagcc gacgaugccc agaaacugcu cgugggccug aaccagagaa     1140

ucguggucaa cggcagaacc cagcggaaca ccaacaccau gaagaacuac cugcugccug     1200

ugguggccca ggccuuugcc agaugggcca aagaguacaa agaggaucaa gaggacgagc     1260

ggccccuggg ccugagagau agacaacugg ucaugggcug cugcugggcc uucagaaggc     1320

acaagaucac cagcaucuac aagcggcccg acacacagac caucaucaaa gugaacagcg     1380

acuuccacag cuucgugcug ccucggaucg gcagcaacac acuggaaauc ggccugcgga     1440

cccggaucag aaagaugcug gaagaacaca aagagcccuc uccacugauc accgccgagg     1500

augugcaaga ggccaaaugu gccgccgacg aggcuaaaga agugcgcgaa gccgaggaac     1560

ugagagccgc acuuccuccu cuggccgccg auguugaaga acccacucug gaagccgacg     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  26
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C07 nsP1-4 ORF and SGP RNA

<400>  26
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaagagc aucagcagac     2580

ggugcaccaa gagcgugacc agcguggugu cuacccuguu cuacgacaag aagaugcgga     2640

cgacaaaccc caaagagaca aagaucguca ucgacaccac cggcagcacc aagccuaagc     2700

aggacgaucu gauccugacc ugcuucagag gcugggucaa gcagcugcag aucgacuaca     2760

agggcaacga gaucaugacc gccgcugccu cucagggccu gacaagaaaa ggcguguacg     2820

ccgugcggua caaagugaac gagaacccuc uguacgcccc uaccagcgag caugugaaug     2880

ugcugcugac ccggaccgag gaccggaucg uuuggaaaac acuggccggc gaucccugga     2940

ucaagacccu gacagccaag uaucccggca acuucaccgc caccaucgag gaauggcagg     3000

ccgagcacga ugccaucaug cggcacaucc uggaaagacc cgauccuacc gacguguucc     3060

agaacaaggc caacgugugc ugggccaaag cucuggugcc ugugcugaaa accgccggca     3120

ucgauaugac caccgagcag uggaacaccg uggacuacuu cgagacagac aaggcccaca     3180

gcgccgagau cgugcugaau cagcugugcg ugcgguucuu cggccuggau cuggauagcg     3240

gccuguucuc ugcuccuacc gugccucuga gcauccggaa caaccacugg gacaacagcc     3300

ccucuccuaa uauguacggc cugaacaaag aagucgugcg gcagcugagc agaagauacc     3360

cacagcugcc uagagccgug gccacaggca gaguguacga caugaauacc ggcacacugc     3420

ggaacuacga ccccagaauc aaucuggugc ccgugaacag aaggcugccc cacgcucugg     3480

uucugcacca caaugagcac ccucagagcg acuucagcag cuucgugucc aagcugaagg     3540

gcagaaccgu gcugguugug ggcgagaagc ugucugugcc uggcaagaug guggacuggc     3600

ugagcgauag acccgaggcc accuuuagag ccagacugga ccuuggaauc ccuggcgacg     3660

ugcccaaaua cgacaucauc uucgugaacg ugcggacgcc cuacaaguac caccacuacc     3720

agcagugcga ggaccacgcc aucaagcuga gcaugcugac caagaaggcc ugccugcacc     3780

ugaauccugg cggcaccugu gugucuaucg gcuacggcua ugccgacaga gccagcgagu     3840

cuaucaucgg cgccauugcc agacaguuca aguucagcag agugugcaag cccaagagca     3900

gccuggaaga gacagaggug cuguucgugu ucaucggcua ugaccggaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  27
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C08 nsP1-4 ORF and SGP RNA

<400>  27
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggaa aaggugcacg       60

uggacaucga agaggacagc ccauuccuga gagcccugca gagaagcuuc ccucaguucg      120

agguggaagc caaacaagug accgacaacg aucacgccaa cgcgagggcc uucucucacc      180

ucgcaagcaa gcugaucgag acagaggugg accccagcga caccauccug gauauuggau      240

cugccccugc cagaagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  28
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C09 nsP1-4 ORF and SGP RNA

<400>  28
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggccagaaa uaucggccug uguagcagcg acgugaugga aagauccaga cggggcauga      720

gcauccugcg gaagaaguac cugaagccua gcaacaacgu gcuguucagc gugggcagca      780

ccaucuacca cgagaagagg gaccugcugc ggagcuggca ucugccuucc guguuucacc      840

ugagaggcaa gcagaacuac accuguagau gcgagacaau cguguccugc gacggcuacg      900

uggucaagcg gaucgccauu ucuccuggcc uguacggcaa gccuucuggc uaugccgcca      960

ccaugcacag agaaggcuuu cuguguugca aagugaccga cacacugaac ggcgagcggg     1020

uguccuuucc uguguguacc uaugugcccg ccacacugug cgaucagaug acaggcauuc     1080

uggccaccga cgugucagcc gacgaugccc agaaacugcu cgugggccug aaccagagaa     1140

ucguggucaa cggcagaacc cagcggaaca ccaacaccau gaagaacuac cugcugccug     1200

ugguggccca ggccuuugcc agaugggcca aagaguacaa agaggaucaa gaggacgagc     1260

ggccccuggg ccugagagau agacaacugg ucaugggcug cugcugggcc uucagaaggc     1320

acaagaucac cagcaucuac aagcggcccg acacacagac caucaucaaa gugaacagcg     1380

acuuccacag cuucgugcug ccucggaucg gcagcaacac acuggaaauc ggccugcgga     1440

cccggaucag aaagaugcug gaagaacaca aagagcccuc uccacugauc accgccgagg     1500

augugcaaga ggccaaaugu gccgccgacg aggcuaaaga agugcgcgaa gccgaggaac     1560

ugagagccgc acuuccuccu cuggccgccg auguugaaga acccacucug gaagccgacg     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaagagc aucagcagac     2580

ggugcaccaa gagcgugacc agcguggugu cuacccuguu cuacgacaag aagaugcgga     2640

cgacaaaccc caaagagaca aagaucguca ucgacaccac cggcagcacc aagccuaagc     2700

aggacgaucu gauccugacc ugcuucagag gcugggucaa gcagcugcag aucgacuaca     2760

agggcaacga gaucaugacc gccgcugccu cucagggccu gacaagaaaa ggcguguacg     2820

ccgugcggua caaagugaac gagaacccuc uguacgcccc uaccagcgag caugugaaug     2880

ugcugcugac ccggaccgag gaccggaucg uuuggaaaac acuggccggc gaucccugga     2940

ucaagacccu gacagccaag uaucccggca acuucaccgc caccaucgag gaauggcagg     3000

ccgagcacga ugccaucaug cggcacaucc uggaaagacc cgauccuacc gacguguucc     3060

agaacaaggc caacgugugc ugggccaaag cucuggugcc ugugcugaaa accgccggca     3120

ucgauaugac caccgagcag uggaacaccg uggacuacuu cgagacagac aaggcccaca     3180

gcgccgagau cgugcugaau cagcugugcg ugcgguucuu cggccuggau cuggauagcg     3240

gccuguucuc ugcuccuacc gugccucuga gcauccggaa caaccacugg gacaacagcc     3300

ccucuccuaa uauguacggc cugaacaaag aagucgugcg gcagcugagc agaagauacc     3360

cacagcugcc uagagccgug gccacaggca gaguguacga caugaauacc ggcacacugc     3420

ggaacuacga ccccagaauc aaucuggugc ccgugaacag aaggcugccc cacgcucugg     3480

uucugcacca caaugagcac ccucagagcg acuucagcag cuucgugucc aagcugaagg     3540

gcagaaccgu gcugguugug ggcgagaagc ugucugugcc uggcaagaug guggacuggc     3600

ugagcgauag acccgaggcc accuuuagag ccagacugga ccuuggaauc ccuggcgacg     3660

ugcccaaaua cgacaucauc uucgugaacg ugcggacgcc cuacaaguac caccacuacc     3720

agcagugcga ggaccacgcc aucaagcuga gcaugcugac caagaaggcc ugccugcacc     3780

ugaauccugg cggcaccugu gugucuaucg gcuacggcua ugccgacaga gccagcgagu     3840

cuaucaucgg cgccauugcc agacaguuca aguucagcag agugugcaag cccaagagca     3900

gccuggaaga gacagaggug cuguucgugu ucaucggcua ugaccggaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  29
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C10 nsP1-4 ORF and SGP RNA

<400>  29
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc cuacaaguac caccacuacc     3720

agcagugcga ggaccacgcc aucaagcuga gcaugcugac caagaaggcc ugccugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucaucggcua cgacagaaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaagu acgccugcaa caacgaguac ugggagacau     6420

ucaaagagaa ccccauccgg cugaccgagg aaaacguggu caacuacauc accaagcuga     6480

agggccccaa agccgccgcu cuguuugcca agacacacaa ccugaacaug cugcaggaca     6540

uccccaugga cagauucgug auggaccuga agcgggacgu gaaagugacc ccuggcacca     6600

agcacaccga ggaacggccu aaggugcaag ugauccaggc cgcugauccu cuggccacag     6660

ccuaucugug uggcauccac agagaacucg ugcggagacu gaaugccgug cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg cugaugauuc uggaagaucu cggaguggac gccgagcugc     6900

ugacacugau ugaagccgcc uuuggcgaga ucagcagcau ccaucugccu accaagacca     6960

aguucaaguu cggcgccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaacaggc agcccuugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  30
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C11 nsP1-4 ORF and SGP RNA

<400>  30
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauaugccg uggauggccc uacaagccug uaccaccagg      540

ccaacaaggg cgucagagug gccuacugga ucggcuucga caccacaccu uucauguuca      600

agaaccuggc uggcgcuuac cccagcuaca gcacaaacug ggccgacgaa accguguuaa      660

cggccagaaa uaucggccug uguagcagcg acgugaugga aagauccaga cggggcauga      720

gcauccugcg gaagaaguac cugaagccua gcaacaacgu gcuguucagc gugggcagca      780

ccaucuacca cgagaagagg gaccugcugc ggagcuggca ucugccuucc guguuucacc      840

ugagaggcaa gcagaacuac accuguagau gcgagacaau cguguccugc gacggcuacg      900

uggucaagcg gaucgccauu ucuccuggcc uguacggcaa gccuucuggc uaugccgcca      960

ccaugcacag agaaggcuuu cuguguugca aagugaccga cacacugaac ggcgagcggg     1020

uguccuuucc uguguguacc uaugugcccg ccacacugug cgaucagaug acaggcauuc     1080

uggccaccga cgugucagcc gacgaugccc agaaacugcu cgugggccug aaccagagaa     1140

ucguggucaa cggcagaacc cagcggaaca ccaacaccau gaagaacuac cugcugccug     1200

ugguggccca ggccuuugcc agaugggcca aagaguacaa agaggaucaa gaggacgagc     1260

ggccccuggg ccugagagau agacaacugg ucaugggcug cugcugggcc uucagaaggc     1320

acaagaucac cagcaucuac aagcggcccg acacacagac caucaucaaa gugaacagcg     1380

acuuccacag cuucgugcug ccucggaucg gcagcaacac acuggaaauc ggccugcgga     1440

cccggaucag aaagaugcug gaagaacaca aagagcccuc uccacugauc accgccgagg     1500

augugcaaga ggccaaaugu gccgccgacg aggcuaaaga agugcgcgaa gccgaggaac     1560

ugagagccgc acuuccuccu cuggccgccg auguugaaga acccacucug gaagccgacg     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagcgagaag cugagcugca uucacccucu ggccgagcaa gugaucguga     1800

ucacacacag cggccggaag ggcagauaug ccguggaacc uuaucacggc aagguggugg     1860

ugccugaggg acacgcuauu ccagugcagg acuuucaggc ccugagcgag ucugccacca     1920

ucguguacaa cgagcgcgag uucgugaaca gauaccugca ccacauugcc acacacggcg     1980

gagcccugaa caccgacgaa gaguacuaca agaccgugaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggauagcgug cugcugaacg gcugcaagca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccua agcagugcgg cuucuucaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaagagc aucagcagac     2580

ggugcaccaa gagcgugacc agcguggugu cuacccuguu cuacgacaag aagaugcgga     2640

cgacaaaccc caaagagaca aagaucguca ucgacaccac cggcagcacc aagccuaagc     2700

aggacgaucu gauccugacc ugcuucagag gcugggucaa gcagcugcag aucgacuaca     2760

agggcaacga gaucaugacc gccgcugccu cucagggccu gacaagaaaa ggcguguacg     2820

ccgugcggua caaagugaac gagaacccuc uguacgcccc uaccagcgag caugugaaug     2880

ugcugcugac ccggaccgag gaccggaucg uuuggaaaac acuggccggc gaucccugga     2940

ucaagacccu gacagccaag uaucccggca acuucaccgc caccaucgag gaauggcagg     3000

ccgagcacga ugccaucaug cggcacaucc uggaaagacc cgauccuacc gacguguucc     3060

agaacaaggc caacgugugc ugggccaaag cucuggugcc ugugcugaaa accgccggca     3120

ucgauaugac caccgagcag uggaacaccg uggacuacuu cgagacagac aaggcccaca     3180

gcgccgagau cgugcugaau cagcugugcg ugcgguucuu cggccuggau cuggauagcg     3240

gccuguucuc ugcuccuacc gugccucuga gcauccggaa caaccacugg gacaacagcc     3300

ccucuccuaa uauguacggc cugaacaaag aagucgugcg gcagcugagc agaagauacc     3360

cacagcugcc uagagccgug gccacaggca gaguguacga caugaauacc ggcacacugc     3420

ggaacuacga ccccagaauc aaucuggugc ccgugaacag aaggcugccc cacgcucugg     3480

uucugcacca caaugagcac ccucagagcg acuucagcag cuucgugucc aagcugaagg     3540

gcagaaccgu gcugguugug ggcgagaagc ugucugugcc uggcaagaug guggacuggc     3600

ugagcgauag acccgaggcc accuuuagag ccagacugga ccuuggaauc ccuggcgacg     3660

ugcccaaaua cgacaucauc uucgugaacg ugcggacgcc cuacaaguac caccacuacc     3720

agcagugcga ggaccacgcc aucaagcuga gcaugcugac caagaaggcc ugccugcacc     3780

ugaauccugg cggcaccugu gugucuaucg gcuacggcua ugccgacaga gccagcgagu     3840

cuaucaucgg cgccauugcc agacaguuca aguucagcag agugugcaag cccaagagca     3900

gccuggaaga gacagaggug cuguucgugu ucaucggcua ugaccggaag gcccguacgc     3960

acaaccccua caagcugagc agcacccuga ccaacaucua caccggcagc agacugcacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccaca gccacagaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaagu acgccugcaa caacgaguac ugggagacau     6420

ucaaagagaa ccccauccgg cugaccgagg aaaacguggu caacuacauc accaagcuga     6480

agggccccaa agccgccgcu cuguuugcca agacacacaa ccugaacaug cugcaggaca     6540

uccccaugga cagauucgug auggaccuga agcgggacgu gaaagugacc ccuggcacca     6600

agcacaccga ggaacggccu aaggugcaag ugauccaggc cgcugauccu cuggccacag     6660

ccuaucugug uggcauccac agagaacucg ugcggagacu gaaugccgug cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg cugaugauuc uggaagaucu cggaguggac gccgagcugc     6900

ugacacugau ugaagccgcc uuuggcgaga ucagcagcau ccaucugccu accaagacca     6960

aguucaaguu cggcgccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaacaggc agcccuugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  31
<211>  8428
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C13 nsP1-4_GFP ORF and SGP RNA

<400>  31
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaguu cggcgccaug augaaguccg gcauguuucu gacccuguuc gugaacaccg     7020

ugaucaacau cgugaucgcc agccgggugc ugagagagag acugacagga ucuccuugcg     7080

ccgccuucau cggcgacgac aauaucguga agggcgugaa guccgacaag cugauggccg     7140

auagaugcgc caccuggcug aacauggaag ugaagaucau cgacgccguc gugggcgaga     7200

aggccccuua uuuuugcggc ggcuucaucc ugugcgacag cgugacaggc acagccugca     7260

gaguugccga uccucugaag cggcuguuca agcugggaaa accucuggcc gccgacgacg     7320

agcacgacga cgauagacgu agagcccugc acgaggaauc caccagaugg aacagagugg     7380

gcauccugag cgagcugugc aaggccgugg aaagcagaua cgagacagug ggcaccagca     7440

ucauugugau ggcaaugacc acacuggcca gcagcgugaa aagcuucagc uaccuaaggg     7500

gcgccccuau cacacuguac ggcucuggcg aaggcagagg cagccuucug acauguggcg     7560

acguggaaga gaaccccgga ccugugucua agggcgaaga acuguuuacc ggcguggugc     7620

ccauccuggu ggaacuggau ggggauguga acggccacaa guucagcguu agcggagaag     7680

gcgaaggcga cgccacauac ggaaagcuga cccugaaguu caucugcacc accggcaagc     7740

ugccugugcc auggccuaca cuggucacca cacugacaua cggcgugcag ugcuucagca     7800

gauaccccga ccauaugaag cagcacgacu ucuucaagag cgccaugccu gagggcuacg     7860

ugcaagagcg gaccaucuuc uuuaaggacg acggcaacua caagaccagg gccgaaguga     7920

aguucgaggg cgacacccug gucaaccgga ucgagcugaa gggcaucgac uucaaagagg     7980

acggcaauau ccugggccac aagcucgagu acaacuacaa cagccacaac guguacauca     8040

uggccgacaa gcagaaaaac ggcaucaaag ugaacuucaa gauccggcac aacaucgagg     8100

acggcucugu gcagcuggcc gaucacuacc agcagaacac acccaucgga gauggcccug     8160

ugcugcugcc cgauaaccac uaccugagca cccagagcaa gcugagcaag gaccccaacg     8220

agaagcggga ccacauggug cugcuggaau uugugacagc cgccggaauc acccucggca     8280

uggaugagcu guacaaguga acuuccauca uaguuauggc caugacuacu cuagcuagca     8340

guguuaaauc auucagcuac cugagagggg ccccuauaac ucucuacggc uaaccugaau     8400

ggacuacgac auagucuagu ccgccaag                                        8428


<210>  32
<211>  8353
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct,  nsP1-4_3Cpro and SGP_VEEVrep-nsP4[3C]

<400>  32
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaguu cggcgccaug augaaguccg gcauguuucu gacccuguuc gugaacaccg     7020

ugaucaacau cgugaucgcc agccgggugc ugagagagag acugacagga ucuccuugcg     7080

ccgccuucau cggcgacgac aauaucguga agggcgugaa guccgacaag cugauggccg     7140

auagaugcgc caccuggcug aacauggaag ugaagaucau cgacgccguc gugggcgaga     7200

aggccccuua uuuuugcggc ggcuucaucc ugugcgacag cgugacaggc acagccugca     7260

gaguugccga uccucugaag cggcuguuca agcugggaaa accucuggcc gccgacgacg     7320

agcacgacga cgauagacgu agagcccugc acgaggaauc caccagaugg aacagagugg     7380

gcauccugag cgagcugugc aaggccgugg aaagcagaua cgagacagug ggcaccagca     7440

ucauugugau ggcaaugacc acacuggcca gcagcgugaa aagcuucagc uaccuaaggg     7500

gcgccccuau cacacuguac ggcucuggcg aaggcagagg cagccuucug acauguggcg     7560

acguggaaga gaaccccgga ccuaguggug ccccaccgac cgacuugcaa aagaugguca     7620

ugggcaacac aaagccuguu gagcucaucc uugacgggaa gacaguagcc aucuguugug     7680

cuacuggagu guuuggcacu gcuuaccucg ugccucguca ucuuuucgca gagaaguaug     7740

acaagaucau gcuggauggc agagccauga cagacaguga cuacagagug uuugaguuug     7800

agauuaaagu aaaaggacag gacaugcucu cagacgcugc gcucauggug cuccaccgug     7860

ggaaccgcgu gagagauauc acgaaacacu uucgugauac agcaagaaug aagaaaggca     7920

cccccgucgu cggugugguc aacaacgccg acguugggag acugauuuuc ucuggugagg     7980

cccucaccua caaggauauu guagugugca uggacggaga caccaugccu agccucuuug     8040

ccuacaaagc cgccaccaag gcaggcuacu guggaggagc cguucucgcc aaggacgggg     8100

ccgacacuuu caucgucggc acucacuccg caggaggcaa uggaguugga uacugcucau     8160

gcguuuccaa guccaugcuu cucagaauga aggcacacgu ugacccugaa ccacaacacg     8220

aguagacuuc caucauaguu auggccauga cuacucuagc uagcaguguu aaaucauuca     8280

gcuaccugag aggggccccu auaacucucu acggcuaacc ugaauggacu acgacauagu     8340

cuaguccgcc aag                                                        8353


<210>  33
<211>  2322
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, 01 Manisa P1 pr _ RNA coding sequence (SG 
       ORF)

<400>  33
augggagcug gacagagcuc cccugcuacc ggcagccaga aucaguccgg caacaccggc       60

uccaucauca acaacuacua caugcagcag uaccagaaca gcauggacac ccagcugggc      120

gacaacgcua ccagcggcgg cuccaacgag ggaagcaccg acaccaccuc cacccacacc      180

accaacaccc agaacaacga cugguucucc aagcuggcca gcagcgccuu cagcggccug      240

uucggagccc ugcuggccga caagaagacc gaggagacaa cccugcugga ggaccggauc      300

cugaccacca gaaacggaca cacuaccucc accacccaga gcuccguggg agugaccuac      360

ggauacgcua ccgcugagga cuucgugucc ggaccaaaca ccuccggccu ggagacaagg      420

guggcucagg cugagagauu cuucaagacc caccuguucg acugggugac cagcgaccca      480

uucggaagau gccaccugcu ggagcugccc accgaccaca agggcgugua cggcagccug      540

accgacuccu acgccuacau gagaaacgga ugggacgugg aggugaccgc ugugggaaac      600

caguucaacg gcggaugccu gcugguggcu auggugcccg agcugugcuc cauccagaag      660

agggagcugu accagcugac ccuguucccc caccaguuca ucaaccccag aaccaacaug      720

accgcucaca ucaccgugcc cuucguggga gugaaccggu acgaccagua caaggugcac      780

aagcccugga cccugguggu caugguggug gccccacuga ccgugaacag cgagggagcc      840

ccacagauca agguguacgc caacaucgcu ccaaccaacg ugcacguggc uggagaguuc      900

cccuccaaag agggcaucuu cccuguggcu ugcagcgacg gauacggcgg ccuggugacc      960

accgacccaa agaccgcuga cccagccuac ggcaaggugu ucaacccacc ccggaacaug     1020

cugccuggac gcuucaccaa cuuccuggac guggcugagg ccugcccaac cuuccugcac     1080

uucgagggcg acgugcccua cgugaccacc aagaccgacu ccgacagagu gcuggcccag     1140

uucgaccugu cccuggccgc caagcacaug agcaacaccu uccuggccgg ccuggcccag     1200

uacuacaccc aguacagcgg caccaucaac cugcacuuca uguucaccgg accaaccgac     1260

gcuaaggcua gguacaugau cgcuuacgcc ccacccggaa uggagccccc aaagaccccu     1320

gaggcugcug cucacugcau ccacgccgag ugggacaccg gccugaacag caaguucacc     1380

uucuccaucc ccuaccugag cgcugcugac uacgcuuaca ccgccuccga caccgcugag     1440

acaaccaacg ugcagggcug ggugugccug uuccagauca cccacggcaa ggcugacggc     1500

gacgcucugg uggugcuggc cagcgccggc aaggacuucg agcugaggcu gcccguggac     1560

gcuagaaccc agaccaccag cgcuggagag uccgcugacc cagugaccgc caccguggag     1620

aacuacggcg gcgagacaca ggugcagcgg aggcagcaca ccgacguguc cuucauccug     1680

gacagauucg ugaaggugac ccccaaggac cagaucaacg ugcuggaccu gaugcagacc     1740

ccugcucaca cccugguggg agcccugcug cggaccgcca ccuacuacuu cgccgaccug     1800

gagguggccg ugaagcacga gggcaaccug accugggugc ccaacggagc uccugaggcu     1860

gcccuggaca acaccaccaa ccccaccgcu uaccauaagg ccccacugac ccggcuggcc     1920

cugcccuaca ccgccccaca ccgcgugcug gccaccgugu acaacggcaa cugcaaguac     1980

ggcgacggca ccguggccaa cgugcggggc gaccugcagg ugcuggccca gaaggcugcu     2040

agagcccugc ccaccagcuu caacuacggc gccaucaagg ccaccagagu gaccgagcug     2100

cuguacagga ugaagagagc cgagacauac ugccccaggc cccugcuggc cauccaccca     2160

gaccaggcca gacacaagca gaagaucgug gcccccguga agcagcugcu gaacuucgac     2220

cugcugaagc uggccggcga cguggagucc aacccuggac ccuucuucuu cagcgacgug     2280

cgcagcaacu ucuccaagcu gguggagaca aucaaccagu ga                        2322


<210>  34
<211>  8848
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, nsP1-4-STING pr ORF, and 
       SGP_VEEVrep-nsP4[STING]

<400>  34
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaguu cggcgccaug augaaguccg gcauguuucu gacccuguuc gugaacaccg     7020

ugaucaacau cgugaucgcc agccgggugc ugagagagag acugacagga ucuccuugcg     7080

ccgccuucau cggcgacgac aauaucguga agggcgugaa guccgacaag cugauggccg     7140

auagaugcgc caccuggcug aacauggaag ugaagaucau cgacgccguc gugggcgaga     7200

aggccccuua uuuuugcggc ggcuucaucc ugugcgacag cgugacaggc acagccugca     7260

gaguugccga uccucugaag cggcuguuca agcugggaaa accucuggcc gccgacgacg     7320

agcacgacga cgauagacgu agagcccugc acgaggaauc caccagaugg aacagagugg     7380

gcauccugag cgagcugugc aaggccgugg aaagcagaua cgagacagug ggcaccagca     7440

ucauugugau ggcaaugacc acacuggcca gcagcgugaa aagcuucagc uaccuaaggg     7500

gcgccccuau cacacuguac ggcucuggcg aaggcagagg cagccuucug acauguggcg     7560

acguggaaga gaaccccgga ccuccucaca gcucucugca cccuagcauc ccuuguccua     7620

gaggacacgg cgcccagaaa gcugcucugg uucugcuguc ugccugccug guuacacugu     7680

ggggacuggg agagccuccu gagcacacac ugagauaccu ggugcugcac cuggcuucuc     7740

ugcagcuggg acugcugcug aacggcgugu guucucuggc cgaggaacug agacacaucc     7800

acagcagaua caggggcagc uacuggcgga cagucagagc uugucugggc ugcccucuua     7860

gaagaggcgc ucugcugcug cuguccaucu acuucuacua cagccugccu aacgcugugg     7920

gcccuccuuu cacauggaug cuggcucugc ugggccuguc ucaggcucug aauauccugc     7980

uggggcugaa aggccuggcu ccugcugaaa ucucugccgu gugcgagaag ggcaacuucu     8040

cuguggcuca cggccuggcc ugguccuacu acaucggaua ccugagacug auccugccug     8100

agcugcaggc cagaaucaga accuacaacc agcacuacaa caaccugcug agaggcgcug     8160

ugucccagag acuguacauc cugcugccuc uggacugugg cgugccagac aaccugucua     8220

uggccgaucc uaacauccgg uuucuggaca agcugccuca gcagacaggc gaucacgccg     8280

gcaucaagga cagaguguac agcaacagca ucuacgagcu gcuggaaaac ggccagcgag     8340

ccggaacaug cgugcuggaa uaugccacac cucugcagac ccuguucgcc augagccagu     8400

acucucaggc cggcuucagc cgcgaggaua ugcuggaaca ggccaagcug uucugcagga     8460

cccucgagga cauccuggcu gaugcuccag agagccagaa caacugcaga cugaucgccu     8520

accaagagcc ugccgacgac agcagcuuua gccugagcca agaggugcug agacaccuga     8580

gacaagaaga gaaagaggaa gucaccgucg gcagccugaa aaccagcgcc gugccuagca     8640

ccagcaccau gucucaagaa cccgaacugc ugaucuccgg cauggaaaag ccccugccuc     8700

ugagaaccga cuucagcuga acuuccauca uaguuauggc caugacuacu cuagcuagca     8760

guguuaaauc auucagcuac cugagagggg ccccuauaac ucucuacggc uaaccugaau     8820

ggacuacgac auagucuagu ccgccaag                                        8848


<210>  35
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C12_nsP1-4 ORF, and SGP

<400>  35
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggccagaaa caucggccug ugcagcagcg acgugaugga acggucuaga cggggcauga      720

gcauccugcg gaagaaguac cugaagccua gcaacaacgu gcuguucagc gugggcagca      780

ccaucuacca cgagaagagg gaccugcugc ggagcuggca ucugccuucc guguuucacc      840

ugagaggcaa gcagaacuac accuguagau gcgagacaau cguguccugc gacggcuacg      900

uggucaagcg gaucgccauu ucuccuggcc uguacggcaa gccuucuggc uaugccgcca      960

ccaugcacag agaaggcuuu cuguguugca aagugaccga cacacugaac ggcgagcggg     1020

uguccuuucc uguguguacc uaugugcccg ccacacugug cgaucagaug acaggcauuc     1080

uggccaccga cgugucagcc gacgaugccc agaaacugcu cgugggccug aaccagagaa     1140

ucguggucaa cggcagaacc cagcggaaca ccaacaccau gaagaacuac cugcugccug     1200

ugguggccca ggccuuugcc agaugggcca aagaguacaa agaggaucaa gaggacgagc     1260

ggccccuggg ccugagagau agacaacugg ucaugggcug cugcugggcc uucagaaggc     1320

acaagaucac cagcaucuac aagcggcccg acacacagac caucaucaaa gugaacagcg     1380

acuuccacag cuucgugcug ccucggaucg gcagcaacac acuggaaauc ggccugcgga     1440

cccggaucag aaagaugcug gaagaacaca aagagcccuc uccacugauc accgccgagg     1500

augugcaaga ggccaaaugu gccgccgacg aggcuaaaga agugcgcgaa gccgaggaac     1560

ugagagccgc acuuccuccu cuggccgccg auguugaaga acccacucug gaagccgacg     1620

uggaccugau gcuucaagaa gccggcgcug gcagcgugga aacaccuaga ggacugauca     1680

aagucaccag cuacgccggc gaggacaaga ucggaucuua ugccgugcug agcccucagg     1740

cugugcugaa gucugagaag cugagcugca uucacccacu ggccgagcaa gugaucguga     1800

ucacacacag cggccggaag ggcagauaug ccguggaacc uuaucacggc aagguggugg     1860

ugccugaggg acacgcuauu ccagugcagg acuuucaggc ccugagcgag ucugccacca     1920

ucguguacaa cgagcgcgag uucgugaaca gauaccugca ccacauugcc acacacggcg     1980

gagcccugaa uaccgacgaa gaguacuaca agaccgugaa gcccagcgag cacgacggcg     2040

aguaccugua cgacaucgac agaaagcagu gcgugaagaa agagcugguc accggcuugg     2100

gacugacagg cgaacuggug gauccuccau uccacgaguu ugccuacgag agccugagaa     2160

ccagaccugc cgcuccuuac caggugccaa caaucggagu guauggcgug ccaggcucug     2220

gcaagagcgg caucauuaag agcgccguga ccaaaaagga ccugguggug uccgccaaga     2280

aagagaacug cgccgagauc auccgggacg ugaagaagau gaagggccuc gacgugaacg     2340

ccagaaccgu ggauagcgug cugcugaacg gaugcaagca ccccguggaa acccuguaca     2400

ucgaugaggc cuucgccugc caugccggaa cacugagagc acugaucgcc aucaucagac     2460

ccaagaaagc cgugcugugc ggcgacccua agcagugugg cuucuucaau augaugugcc     2520

ugaaggugca cuucaaccac gagaucugca cccagguguu ccacaagagc aucagcagac     2580

ggugcaccaa gagcgugacc agcguggugu cuacccuguu cuacgacaag aagaugcgga     2640

cgacaaaccc caaagagacu aagaucguca ucgacaccac cggcuccacc aagccuaagc     2700

aggacgaucu gauccugacc ugcuucagag gcugggucaa gcagcugcag aucgacuaca     2760

agggcaacga gaucaugacc gcugccgcuu cucagggacu gaccagaaaa ggcguguacg     2820

ccgugcggua caaagugaau gagaacccuc uguacgcccc uaccuccgag caugugaaug     2880

uccugcugac caggaccgag gaccggaucg uguggaaaac acuggcuggc gaccccugga     2940

ucaagacccu gacagccaag uaucccggca acuucaccgc cacaaucgag gaauggcagg     3000

ccgagcacga ugccauuaug cggcacaucc uggaacggcc cgauccuacc gauguguucc     3060

agaacaaggc caacgugugc ugggcuaaag cccuggugcc agugcugaaa accgccggca     3120

ucgauaugac caccgagcag uggaauaccg uggacuacuu cgagacagac aaggcccacu     3180

cugccgagau cgugcugaau cagcugugcg ugcgguucuu cggccuggau cuggauagcg     3240

gccuguuuag cgcuccuacc gugccucuga gcauccggaa caaccacugg gacaacagcc     3300

ccucuccuaa uauguacggc cugaacaaag aaguugugcg gcagcugagc agaagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  36
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C13_nsP1-4 ORF, and SGP

<400>  36
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggccagaaa caucggccug ugcagcagcg acgugaugga acggagcaga cggggcauga      720

gcauccugcg gaagaaguac cugaagccca gcaacaacgu gcuguucagc gugggcagca      780

ccaucuacca cgagaagagg gaccugcugc ggagcuggca ccugcccagc guguuccacc      840

ugagaggcaa gcagaacuac accugcagau gcgagacaau cgugagcugc gacggcuacg      900

uggucaagcg gaucgccaua agccccggcc uguacggcaa gcccagcggc uacgccgcca      960

ccaugcacag agaaggcuuc cugugcugca aagugaccga cacacugaac ggcgagcggg     1020

ugagcuuccc cgugugcacc uacgugcccg ccacacugug cgaccagaug acaggcauac     1080

uggccaccga cgugagcgcc gacgacgccc agaaacugcu cgugggccug aaccagagaa     1140

ucguggucaa cggcagaacc cagcggaaca ccaacaccau gaagaacuac cugcugccag     1200

ugguggccca ggccuucgcc agaugggcca aagaguacaa agaggaccaa gaggacgagc     1260

ggccccuggg ccugagagac agacaacugg ucaugggcug cugcugggcc uucagaaggc     1320

acaagaucac cagcaucuac aagcggcccg acacacagac caucaucaaa gugaacagcg     1380

acuuccacag cuucgugcug ccacggaucg gcagcaacac acuggaaauc ggccugcgga     1440

cccggaucag aaagaugcug gaagaacaca aagagcccag cccacugauc accgccgagg     1500

acgugcaaga ggccaaaugc gccgccgacg aggcaaaaga agugcgcgaa gccgaggaac     1560

ugagagccgc acucccccca cuggccgccg acguagaaga acccacccug gaagccgacg     1620

uggaccugau gcuccaagaa gccggcgcag gcagcgugga aacaccgaga ggacugauca     1680

aagucaccag cuacgccggc gaggacaaga ucggaagcua cgccgugcug agcccccagg     1740

ccgugcugaa aagcgagaag cugagcugca uccacccacu ggccgagcaa gugaucguga     1800

ucacacacag cggccggaag ggcagauacg ccguggaacc cuaccacggc aagguggugg     1860

ugccagaggg acacgcaauc ccagugcagg acuuccaggc ccugagcgag agcgccacca     1920

ucguguacaa cgagcgcgag uucgugaaca gauaccugca ccacauagcc acacacggcg     1980

gagcccugaa caccgacgaa gaguacuaca agaccgugaa gcccagcgag cacgacggcg     2040

aguaccugua cgacaucgac agaaagcagu gcgugaagaa agagcugguc accggccuag     2100

gacugacagg cgaacuggug gacccacccu uccacgaguu cgccuacgag agccugagaa     2160

ccagaccagc cgcacccuac caggugccaa caaucggagu guacggcgug ccaggcagcg     2220

gcaagagcgg caucauaaag agcgccguga ccaaaaagga ccugguggug agcgccaaga     2280

aagagaacug cgccgagauc auccgggacg ugaagaagau gaagggccuc gacgugaacg     2340

ccagaaccgu ggacagcgug cugcugaacg gaugcaagca ccccguggaa acccuguaca     2400

ucgacgaggc cuucgccugc cacgccggaa cacugagagc acugaucgcc aucaucagac     2460

ccaagaaagc cgugcugugc ggcgacccca agcagugcgg cuucuucaac augaugugcc     2520

ugaaggugca cuucaaccac gagaucugca cccagguguu ccacaagagc aucagcagac     2580

ggugcaccaa gagcgugacc agcgugguga gcacccuguu cuacgacaag aagaugcgga     2640

cgacaaaccc caaagagacc aagaucguca ucgacaccac cggcagcacc aagccaaagc     2700

aggacgaccu gauccugacc ugcuucagag gcugggucaa gcagcugcag aucgacuaca     2760

agggcaacga gaucaugacc gccgccgcaa gccagggacu gaccagaaaa ggcguguacg     2820

ccgugcggua caaagugaac gagaacccac uguacgcccc caccagcgag cacgugaacg     2880

uccugcugac caggaccgag gaccggaucg uguggaaaac acuggccggc gaccccugga     2940

ucaagacccu gacagccaag uaccccggca acuucaccgc cacaaucgag gaauggcagg     3000

ccgagcacga cgccauaaug cggcacaucc uggaacggcc cgacccaacc gacguguucc     3060

agaacaaggc caacgugugc ugggcaaaag cccuggugcc agugcugaaa accgccggca     3120

ucgacaugac caccgagcag uggaacaccg uggacuacuu cgagacagac aaggcccaca     3180

gcgccgagau cgugcugaac cagcugugcg ugcgguucuu cggccuggac cuggacagcg     3240

gccuguucag cgcacccacc gugccccuga gcauccggaa caaccacugg gacaacagcc     3300

ccagcccaaa cauguacggc cugaacaaag aagucgugcg gcagcugagc agaagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagcgc     4140

uguauaagaa auucccggaa agcuucgauu uacagccgau cgaaguagga aaagcgcgac     4200

uggucaaagg ugcagcuaaa cauaucauuc augccguagg accaaacuuc aacaaaguuu     4260

cggagguuga aggugacaaa caguuggcag aggcuuauga guccaucgcu aagauuguca     4320

acgauaacaa uuacaaguca guagcgauuc cacuguuguc caccggcauc uuuuccggga     4380

acaaagaucg acuaacccaa ucauugaacc auuugcugac agcuuuagac accacugaug     4440

cagauguagc cauauacugc agggacaaga aaugggaaau gacucucaag gaagcagugg     4500

cuaggagaga agcaguggag gagauaugca uauccgacga cucuucagug acagaaccug     4560

augcagagcu ggugagggug cauccgaaga guucuuuggc uggaaggaag ggcuacagca     4620

caagcgaugg caaaacuuuc ucauauuugg aagggaccaa guuucaccag gcggccaagg     4680

auauagcaga aauuaaugcc auguggcccg uugcaacgga ggccaaugag cagguaugca     4740

uguauauccu cggagaaagc augagcagua uuaggucgaa augccccguc gaagagucgg     4800

aagccuccac accaccuagc acgcugccuu gcuugugcau ccaugccaug acuccagaaa     4860

gaguacagcg ccuaaaagcc ucacguccag aacaaauuac ugugugcuca uccuuuccau     4920

ugccgaagua uagaaucacu ggugugcaga agauccaaug cucccagccu auauuguucu     4980

caccgaaagu gccugcguau auucauccaa ggaaguaucu cguggaaaca ccaccgguag     5040

acgagacucc ggagccaucg gcagagaacc aauccacaga ggggacaccu gaacaaccac     5100

cacuuauaac cgaggaugag accaggacua gaacgccuga gccgaucauc aucgaagagg     5160

aagaagagga uagcauaagu uugcugucag auggcccgac ccaccaggug cugcaagucg     5220

aggcagacau ucacgggccg cccucuguau cuagcucauc cugguccauu ccucaugcau     5280

ccgacuuuga uguggacagu uuauccauac uugacacccu ggagggagcu agcgugacca     5340

gcggggcaac gucagccgag acuaacucuu acuucgcaaa gaguauggag uuucuggcgc     5400

gaccggugcc ugcgccucga acaguauuca ggaacccucc acaucccgcu ccgcgcacaa     5460

gaacaccguc acuugcaccc agcagggccu gcucgagaac cagccuaguu uccaccccgc     5520

caggcgugaa uagggugauc acuagagagg agcucgaggc gcuuaccccg ucacgcacuc     5580

cuagcagguc ggucucgaga accagccugg ucuccaaccc gccaggcgua aauaggguga     5640

uuacaagaga ggaguuugag gcguucguag cacaacaaca augacgguuu gaugcgggug     5700

cauacaucuu uuccuccgac accggucaag ggcauuuaca acaaaaauca guaaggcaaa     5760

cggugcuauc cgaaguggug uuggagagga ccgaauugga gauuucguau gccccgcgcc     5820

ucgaccaaga aaaagaagaa uuacuacgca agaaauuaca guuaaauccc acaccugcua     5880

acagaagcag auaccagucc aggaaggugg agaacaugaa agccauaaca gcuagacgua     5940

uucugcaagg ccuagggcau uauuugaagg cagaaggaaa aguggagugc uaccgaaccc     6000

ugcauccugu uccuuuguau ucaucuagug ugaaccgugc cuuuucaagc cccaaggucg     6060

caguggaagc cuguaacgcc auguugaaag agaacuuucc gacuguggcu ucuuacugua     6120

uuauuccaga guacgaugcc uauuuggaca ugguugacgg agcuucaugc ugcuuagaca     6180

cugccaguuu uugcccugca aagcugcgca gcuuuccaaa gaaacacucc uauuuggaac     6240

ccacaauacg aucggcagug ccuucagcga uccagaacac gcuccagaac guccuggcag     6300

cugccacaaa aagaaauugc aaugucacgc aaaugagaga auugcccgua uuggauucgg     6360

cggccuuuaa uguggaaugc uucaagaaau augcguguaa uaaugaauau ugggaaacgu     6420

uuaaagaaaa ccccaucagg cuuacugaag aaaacguggu aaauuacauu accaaauuaa     6480

aaggaccaaa agcugcugcu cuuuuugcga agacacauaa uuugaauaug uugcaggaca     6540

uaccaaugga cagguuugua auggacuuaa agagagacgu gaaagugacu ccaggaacaa     6600

aacauacuga agaacggccc aagguacagg ugauccaggc ugccgauccg cuagcaacag     6660

cguaucugug cggaauccac cgagagcugg uuaggagauu aaaugcgguc cugcuuccga     6720

acauucauac acuguuugau augucggcug aagacuuuga cgcuauuaua gccgagcacu     6780

uccagccugg ggauuguguu cuggaaacug acaucgcguc guuugauaaa agugaggacg     6840

acgccauggc ucugaccgcg uuaaugauuc uggaagacuu agguguggac gcagagcugu     6900

ugacgcugau ugaggcggcu uucggcgaaa uuucaucaau acauuugccc acuaaaacua     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  37
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C14_nsP1-4 ORF, and SGP

<400>  37
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggagggguu ugcggagccc     4140

uguacaagaa guuccccgag agcuucgacc ugcagccuau cgaagugggc aaagccagac     4200

ugguuaaggg cgcugccaag cacaucaucc augccguggg acccaacuuc aacaaggugu     4260

ccgaggugga aggcgacaag cagcuggccg aggccuauga gucuaucgcc aagaucguga     4320

acgacaacaa cuacaagagc guggccauuc cucugcugag caccggcauc uucagcggca     4380

acaaggacag acugacccag agccugaacc aucugcugac agcccuggau accaccgaug     4440

ccgauguggc caucuacugc cgggacaaga aaugggagau gacccugaaa gaagccgugg     4500

ccagacgcga ggccguggaa gagaucugua ucagcgacga cagcagcgug accgagccug     4560

augccgaacu cguuagagug caccccaagu cuagccuggc cggcagaaag ggcuacagca     4620

ccucugaugg caagaccuuc agcuaccugg aaggcaccaa guuccaccag gccgccaagg     4680

auaucgccga gaucaacgcu auguggcccg uggccaccga ggccaaugaa caagugugca     4740

uguacauccu gggcgagagc augagcagca uccgcagcaa guguccugug gaagaguccg     4800

aggccagcac accuccuagc acacugccuu gccugugcau ccacgccaug acaccugaga     4860

gagugcagcg gcugaaggcc ucuagaccug agcagaucac cgugugcagc agcuucccac     4920

ugccuaagua cagaaucacc ggcgugcaga aaauccagug cagccagccu auccuguuca     4980

gcccuaaggu gcccgccuac auucacccca gaaaguaucu gguggaaacc ccaccugugg     5040

acgagacacc ugaaccuagc gccgagaauc agagcaccga gggaacacca gaacagccuc     5100

cacugaucac cgaggacgaa accaggacca gaacacccga gccuaucauc aucgaggaag     5160

aagaagagga cagcaucagc cugcugagcg acggaccuac acaccaggug cugcaagugg     5220

aagccgacau ccauggaccu ccaagcgugu ccagcagcag cuggucuauu ccucacgcca     5280

gcgacuucga cguggacagc cugagcaucc uggacacacu ggaaggcgcc ucugugacau     5340

cuggcgccac auccgccgag acaaacagcu acuucgccaa gagcauggaa uuucuggcca     5400

ggccugugcc ugcuccucgg accguguuua gaaacccucc ucauccugcu ccuagaacca     5460

ggacaccuuc ucuggccccu agcagagccu guagcagaac cagccuggug ucuacaccuc     5520

cuggcgugaa cagagugauc accagagagg aacuggaagc ccugacaccu agcaggaccc     5580

caagcagauc cgugucuaga acaucccugg uguccaaucc uccaggcguc aaccggguca     5640

ucacccggga agaguuugag gccuuugugg cucagcagca gugaagauuc gacgcaggcg     5700

ccuacaucuu cuccagcgau acaggccagg gccaucugca gcagaaaagc gucagacaga     5760

ccgugcuguc cgaaguggug cuggaaagaa ccgagcugga aaucagcuac gccccucggc     5820

uggaccaaga gaaagaagaa cugcugcgga agaaacugca gcugaacccc acaccagcca     5880

acagaagcag auaccagagc cggaaggugg aaaacaugaa ggccaucacc gccagacgga     5940

uccugcaagg ccugggccau uaucugaagg ccgagggcaa aguggaaugc uacagaacac     6000

ugcaccccgu gccucuguac agcagcuccg ugaauagggc cuuuagcagc ccaaaggugg     6060

ccgucgaagc cugcaacgcc augcugaaag aaaacuuccc uaccguggcc uccuacugca     6120

ucauccccga guacgacgcc uaccuggaca ugguggaugg cgcuagcugu ugucuggaua     6180

ccgccagcuu cugccccgcc aagcugagaa gcuuccccaa gaagcacagc uaucuggaac     6240

ccaccaucag auccgccgug ccuuccgcca uucagaauac ccugcagaac gugcuggccg     6300

cugccaccaa gaggaauugc aacgugaccc agaugcgcga gcugcccguu cuggauagcg     6360

ccgccuucaa cguggaaugu uucaagaagu acgccugcaa caacgaguac ugggagacau     6420

ucaaagagaa ccccauccgg cugaccgagg aaaacguggu caacuacauc accaagcuga     6480

agggccccaa agccgccgcu cuguuugcca agacacacaa ccugaacaug cugcaggaca     6540

uccccaugga cagauucgug auggaccuga agcgggacgu gaaagugacc ccuggcacca     6600

agcacaccga ggaacggccu aaagugcaag ugauccaggc cgcugauccu cuggccacag     6660

ccuaucugug uggcauccac agagaacucg ugcggagacu gaaugccgug cugcugccca     6720

acauccacac acuguucgac augagcgccg aggacuucga ugccaucauu gccgagcacu     6780

uccagccugg cgauugcgug cucgagacag auaucgccuc cuucgacaag agcgaggacg     6840

acgccauggc ucugacugcc cugaugaucc uggaagaucu gggcguugac gccgagcugc     6900

ugacacugau ugaagccgcc uuuggcgaga ucagcuccau ccaucugccu accaagacca     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  38
<211>  7561
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, C15_nsP1-4 ORF, and SGP

<400>  38
augggcggcg caugagagaa gcccagacca auuaccuacc caaaauggag aaaguucacg       60

uugacaucga ggaagacagc ccauuccuca gagcuuugca gcggagcuuc ccgcaguuug      120

agguagaagc caagcagguc acugauaaug accaugcuaa ugccagagcg uuuucgcauc      180

uggcuucaaa acugaucgaa acggaggugg acccauccga cacgauccuu gacauuggaa      240

gugcgcccgc ccgcagaaug uauucuaagc acaaguauca uuguaucugu ccgaugagau      300

gugcggaaga uccggacaga uuguauaagu augcaacuaa gcugaagaaa aacuguaagg      360

aaauaacuga uaaggaauug gacaagaaaa ugaaggagcu cgccgccguc augagcgacc      420

cugaccugga aacugagacu augugccucc acgacgacga gucgugucgc uacgaagggc      480

aagucgcugu uuaccaggau guauacgcgg uugacggacc gacaagucuc uaucaccaag      540

ccaauaaggg aguuagaguc gccuacugga uaggcuuuga caccaccccu uuuauguuua      600

agaacuuggc uggagcauau ccaucauacu cuaccaacug ggccgacgaa accguguuaa      660

cggcucguaa cauaggccua ugcagcucug acguuaugga gcggucacgu agagggaugu      720

ccauucuuag aaagaaguau uugaaaccau ccaacaaugu ucuauucucu guuggcucga      780

ccaucuacca cgagaagagg gacuuacuga ggagcuggca ccugccgucu guauuucacu      840

uacguggcaa gcaaaauuac acaugucggu gugagacuau aguuaguugc gacggguacg      900

ucguuaaaag aauagcuauc aguccaggcc uguaugggaa gccuucaggc uaugcugcua      960

cgaugcaccg cgagggauuc uugugcugca aagugacaga cacauugaac ggggagaggg     1020

ucucuuuucc cgugugcacg uaugugccag cuacauugug ugaccaaaug acuggcauac     1080

uggcaacaga ugucagugcg gacgacgcgc aaaaacugcu gguugggcuc aaccagcgua     1140

uagucgucaa cggucgcacc cagagaaaca ccaauaccau gaaaaauuac cuuuugcccg     1200

uaguggccca ggcauuugcu aggugggcaa aggaauauaa ggaagaucaa gaagaugaaa     1260

ggccacuagg acuacgagau agacaguuag ucauggggug uuguugggcu uuuagaaggc     1320

acaagauaac aucuauuuau aagcgcccgg auacccaaac caucaucaaa gugaacagcg     1380

auuuccacuc auucgugcug cccaggauag gcaguaacac auuggagauc gggcugagaa     1440

caagaaucag gaaaauguua gaggagcaca aggagccguc accucucauu accgccgagg     1500

acguacaaga agcuaagugc gcagccgaug aggcuaagga ggugcgugaa gccgaggagu     1560

ugcgcgcagc ucuaccaccu uuggcagcug auguugagga gcccacucug gaagccgaug     1620

ucgacuugau guuacaagag gcuggggccg gcucagugga gacaccucgu ggcuugauaa     1680

agguuaccag cuacgcuggc gaggacaaga ucggcucuua cgcugugcuu ucuccgcagg     1740

cuguacucaa gagugaaaaa uuaucuugca uccacccucu cgcugaacaa gucauaguga     1800

uaacacacuc uggccgaaaa gggcguuaug ccguggaacc auaccauggu aaaguagugg     1860

ugccagaggg acaugcaaua cccguccagg acuuucaagc ucugagugaa agugccacca     1920

uuguguacaa cgaacgugag uucguaaaca gguaccugca ccauauugcc acacauggag     1980

gagcgcugaa cacugaugaa gaauauuaca aaacugucaa gcccagcgag cacgacggcg     2040

aauaccugua cgacaucgac aggaaacagu gcgucaagaa agaacuaguc acugggcuag     2100

ggcucacagg cgagcuggug gauccucccu uccaugaauu cgccuacgag agucugagaa     2160

cacgaccagc cgcuccuuac caaguaccaa ccauaggggu guauggcgug ccaggaucag     2220

gcaagucugg caucauuaaa agcgcaguca ccaaaaaaga ucuaguggug agcgccaaga     2280

aagaaaacug ugcagaaauu auaagggacg ucaagaaaau gaaagggcug gacgucaaug     2340

ccagaacugu ggacucagug cucuugaaug gaugcaaaca ccccguagag acccuguaua     2400

uugacgaagc uuuugcuugu caugcaggua cucucagagc gcucauagcc auuauaagac     2460

cuaaaaaggc agugcucugc ggggauccca aacagugcgg uuuuuuuaac augaugugcc     2520

ugaaagugca uuuuaaccac gagauuugca cacaagucuu ccacaaaagc aucucucgcc     2580

guugcacuaa aucugugacu ucggucgucu caaccuuguu uuacgacaaa aaaaugagaa     2640

cgacgaaucc gaaagagacu aagauuguga uugacacuac cggcaguacc aaaccuaagc     2700

aggacgaucu cauucucacu uguuucagag ggugggugaa gcaguugcaa auagauuaca     2760

aaggcaacga aauaaugacg gcagcugccu cucaagggcu gacccguaaa gguguguaug     2820

ccguucggua caaggugaau gaaaauccuc uguacgcacc caccucagaa caugugaacg     2880

uccuacugac ccgcacggag gaccgcaucg uguggaaaac acuagccggc gacccaugga     2940

uaaaaacacu gacugccaag uacccuggga auuucacugc cacgauagag gaguggcaag     3000

cagagcauga ugccaucaug aggcacaucu uggagagacc ggacccuacc gacgucuucc     3060

agaauaaggc aaacgugugu ugggccaagg cuuuagugcc ggugcugaag accgcuggca     3120

uagacaugac cacugaacaa uggaacacug uggauuauuu ugaaacggac aaagcucacu     3180

cagcagagau aguauugaac caacuaugcg ugagguucuu uggacucgau cuggacuccg     3240

gucuauuuuc ugcacccacu guuccguuau ccauuaggaa uaaucacugg gauaacuccc     3300

cgucgccuaa cauguacggg cugaauaaag aagugguccg ucagcucucu cgcagguacc     3360

cacaacugcc ucgggcaguu gccacuggaa gagucuauga caugaacacu gguacacugc     3420

gcaauuauga uccgcgcaua aaccuaguac cuguaaacag aagacugccu caugcuuuag     3480

uccuccacca uaaugaacac ccacagagug acuuuucuuc auucgucagc aaauugaagg     3540

gcagaacugu ccuggugguc ggggaaaagu uguccguccc aggcaaaaug guugacuggu     3600

ugucagaccg gccugaggcu accuucagag cucggcugga uuuaggcauc ccaggugaug     3660

ugcccaaaua ugacauaaua uuuguuaaug ugaggacccc auauaaauac caucacuauc     3720

agcaguguga agaccaugcc auuaagcuua gcauguugac caagaaagcu ugucugcauc     3780

ugaaucccgg cggaaccugu gucagcauag guuaugguua cgcugacagg gccagcgaaa     3840

gcaucauugg ugcuauagcg cggcaguuca aguuuucccg gguaugcaaa ccgaaauccu     3900

cacuugaaga gacggaaguu cuguuuguau ucauugggua cgaucgcaag gcccguacgc     3960

acaauccuua caagcuuuca ucaaccuuga ccaacauuua uacagguucc agacuccacg     4020

aagccggaug ugcacccuca uaucaugugg ugcgagggga uauugccacg gccaccgaag     4080

gagugauuau aaaugcugcu aacagcaaag gacaaccugg cggaggggug ugcggagccc     4140

uguacaagaa guuccccgag agcuucgacc ugcagccaau cgaagugggc aaagccagac     4200

uggucaaggg cgcagccaag cacaucaucc acgccguggg acccaacuuc aacaagguga     4260

gcgaggugga aggcgacaag cagcuggccg aggccuacga gagcaucgcc aagaucguga     4320

acgacaacaa cuacaagagc guggccauac cccugcugag caccggcauc uucagcggca     4380

acaaggacag acugacccag agccugaacc accugcugac agcccuggac accaccgacg     4440

ccgacguggc caucuacugc cgggacaaga aaugggagau gacccugaaa gaagccgugg     4500

ccagacgcga ggccguggaa gagaucugca ucagcgacga cagcagcgug accgagccag     4560

acgccgaacu cgucagagug caccccaaga gcagccuggc cggcagaaag ggcuacagca     4620

ccagcgacgg caagaccuuc agcuaccugg aaggcaccaa guuccaccag gccgccaagg     4680

acaucgccga gaucaacgca auguggcccg uggccaccga ggccaacgaa caagugugca     4740

uguacauccu gggcgagagc augagcagca uccgcagcaa gugccccgug gaagagagcg     4800

aggccagcac accacccagc acacugcccu gccugugcau ccacgccaug acaccagaga     4860

gagugcagcg gcugaaggcc agcagacccg agcagaucac cgugugcagc agcuucccac     4920

ugcccaagua cagaaucacc ggcgugcaga aaauccagug cagccagcca auccuguuca     4980

gccccaaggu gcccgccuac auacacccca gaaaguaccu gguggaaacc ccacccgugg     5040

acgagacacc cgaaccaagc gccgagaacc agagcaccga gggaacacca gaacagcccc     5100

cacugaucac cgaggacgaa accaggacca gaacacccga gccaaucauc aucgaggaag     5160

aagaagagga cagcaucagc cugcugagcg acggacccac acaccaggug cugcaagugg     5220

aagccgacau ccacggaccc ccaagcguga gcagcagcag cuggagcauc ccccacgcca     5280

gcgacuucga cguggacagc cugagcaucc uggacacacu ggaaggcgcc agcgugacaa     5340

gcggcgccac aagcgccgag acaaacagcu acuucgccaa gagcauggaa uuccuggcca     5400

ggcccgugcc agcaccccgg accguguuca gaaacccccc ucacccagcc cccagaacca     5460

ggacacccag ccuggcccca agcagagccu gcagcagaac cagccuggug agcacacccc     5520

ccggcgugaa cagagugauc accagagagg aacuggaagc ccugacaccc agcaggaccc     5580

caagcagaag cgugagcaga acaagccugg ugagcaaccc accaggcguc aaccggguca     5640

ucacccggga agaguucgag gccuucgugg cacagcagca gugaagauuc gacgcaggcg     5700

ccuacaucuu cagcagcgac acaggccagg gccaccugca gcagaaaagc gucagacaga     5760

ccgugcugag cgaaguggug cuggaaagaa ccgagcugga aaucagcuac gccccccggc     5820

uggaccaaga gaaagaagaa cugcugcgga agaaacugca gcugaacccc acaccagcca     5880

acagaagcag auaccagagc cggaaggugg aaaacaugaa ggccaucacc gccagacgga     5940

uccugcaagg ccugggccac uaccugaagg ccgagggcaa aguggaaugc uacagaacac     6000

ugcaccccgu gccacuguac agcagcagcg ugaacagggc cuucagcagc ccaaaggugg     6060

ccgucgaagc cugcaacgcc augcugaaag aaaacuuccc caccguggcc agcuacugca     6120

ucauccccga guacgacgcc uaccuggaca ugguggacgg cgcaagcugc ugccuggaca     6180

ccgccagcuu cugccccgcc aagcugagaa gcuuccccaa gaagcacagc uaccuggaac     6240

ccaccaucag aagcgccgug ccaagcgcca uucagaacac ccugcagaac gugcuggccg     6300

cagccaccaa gaggaacugc aacgugaccc agaugcgcga gcugcccguc cuggacagcg     6360

ccgccuucaa cguggaaugc uucaagaagu acgccugcaa caacgaguac ugggagacau     6420

ucaaagagaa ccccauccgg cugaccgagg aaaacguggu caacuacauc accaagcuga     6480

agggccccaa agccgcagcc cuguucgcca agacacacaa ccugaacaug cugcaggaca     6540

uccccaugga cagauucgug auggaccuga agcgggacgu gaaagugacc ccaggcacca     6600

agcacaccga ggaacggccc aaagugcaag ugauccaggc cgcagacccc cuggccacag     6660

ccuaccugug cggcauccac agagaacucg ugcggagacu gaacgccgug cugcugccca     6720

acauccacac acuguucgac augagcgccg aggacuucga cgccaucaua gccgagcacu     6780

uccagccagg cgacugcgug cucgagacag acaucgccag cuucgacaag agcgaggacg     6840

acgccauggc acugaccgcc cugaugaucc uggaagaccu gggcguggac gccgagcugc     6900

ugacacugau agaagccgcc uucggcgaga ucagcagcau ccaccugccc accaagacca     6960

aauuuaaauu cggagccaug augaaaucug gaauguuccu cacacuguuu gugaacacag     7020

ucauuaacau uguaaucgca agcagagugu ugagagaacg gcuaaccgga ucaccaugug     7080

cagcauucau uggagaugac aauaucguga aaggagucaa aucggacaaa uuaauggcag     7140

acaggugcgc caccugguug aauauggaag ucaagauuau agaugcugug gugggcgaga     7200

aagcgccuua uuucugugga ggguuuauuu ugugugacuc cgugaccggc acagcgugcc     7260

guguggcaga cccccuaaaa aggcuguuua agcuuggcaa accucuggca gcagacgaug     7320

aacaugauga ugacaggaga agggcauugc augaagaguc aacacgcugg aaccgagugg     7380

guauucuuuc agagcugugc aaggcaguag aaucaaggua ugaaaccgua ggaacuucca     7440

ucauaguuau ggccaugacu acucuagcua gcaguguuaa aucauucagc uaccugagag     7500

gggccccuau aacucucuac ggcuaaccug aauggacuac gacauagucu aguccgccaa     7560

g                                                                     7561


<210>  39
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, VEEV nsP4-2A polyprotein

<400>  39

Tyr Ile Phe Ser Ser Asp Thr Gly Gln Gly His Leu Gln Gln Lys Ser 
1               5                   10                  15      


Val Arg Gln Thr Val Leu Ser Glu Val Val Leu Glu Arg Thr Glu Leu 
            20                  25                  30          


Glu Ile Ser Tyr Ala Pro Arg Leu Asp Gln Glu Lys Glu Glu Leu Leu 
        35                  40                  45              


Arg Lys Lys Leu Gln Leu Asn Pro Thr Pro Ala Asn Arg Ser Arg Tyr 
    50                  55                  60                  


Gln Ser Arg Lys Val Glu Asn Met Lys Ala Ile Thr Ala Arg Arg Ile 
65                  70                  75                  80  


Leu Gln Gly Leu Gly His Tyr Leu Lys Ala Glu Gly Lys Val Glu Cys 
                85                  90                  95      


Tyr Arg Thr Leu His Pro Val Pro Leu Tyr Ser Ser Ser Val Asn Arg 
            100                 105                 110         


Ala Phe Ser Ser Pro Lys Val Ala Val Glu Ala Cys Asn Ala Met Leu 
        115                 120                 125             


Lys Glu Asn Phe Pro Thr Val Ala Ser Tyr Cys Ile Ile Pro Glu Tyr 
    130                 135                 140                 


Asp Ala Tyr Leu Asp Met Val Asp Gly Ala Ser Cys Cys Leu Asp Thr 
145                 150                 155                 160 


Ala Ser Phe Cys Pro Ala Lys Leu Arg Ser Phe Pro Lys Lys His Ser 
                165                 170                 175     


Tyr Leu Glu Pro Thr Ile Arg Ser Ala Val Pro Ser Ala Ile Gln Asn 
            180                 185                 190         


Thr Leu Gln Asn Val Leu Ala Ala Ala Thr Lys Arg Asn Cys Asn Val 
        195                 200                 205             


Thr Gln Met Arg Glu Leu Pro Val Leu Asp Ser Ala Ala Phe Asn Val 
    210                 215                 220                 


Glu Cys Phe Lys Lys Tyr Ala Cys Asn Asn Glu Tyr Trp Glu Thr Phe 
225                 230                 235                 240 


Lys Glu Asn Pro Ile Arg Leu Thr Glu Glu Asn Val Val Asn Tyr Ile 
                245                 250                 255     


Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys Thr His 
            260                 265                 270         


Asn Leu Asn Met Leu Gln Asp Ile Pro Met Asp Arg Phe Val Met Asp 
        275                 280                 285             


Leu Lys Arg Asp Val Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu 
    290                 295                 300                 


Arg Pro Lys Val Gln Val Ile Gln Ala Ala Asp Pro Leu Ala Thr Ala 
305                 310                 315                 320 


Tyr Leu Cys Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn Ala Val 
                325                 330                 335     


Leu Leu Pro Asn Ile His Thr Leu Phe Asp Met Ser Ala Glu Asp Phe 
            340                 345                 350         


Asp Ala Ile Ile Ala Glu His Phe Gln Pro Gly Asp Cys Val Leu Glu 
        355                 360                 365             


Thr Asp Ile Ala Ser Phe Asp Lys Ser Glu Asp Asp Ala Met Ala Leu 
    370                 375                 380                 


Thr Ala Leu Met Ile Leu Glu Asp Leu Gly Val Asp Ala Glu Leu Leu 
385                 390                 395                 400 


Thr Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Ile His Leu Pro 
                405                 410                 415     


Thr Lys Thr Lys Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met Phe 
            420                 425                 430         


Leu Thr Leu Phe Val Asn Thr Val Ile Asn Ile Val Ile Ala Ser Arg 
        435                 440                 445             


Val Leu Arg Glu Arg Leu Thr Gly Ser Pro Cys Ala Ala Phe Ile Gly 
    450                 455                 460                 


Asp Asp Asn Ile Val Lys Gly Val Lys Ser Asp Lys Leu Met Ala Asp 
465                 470                 475                 480 


Arg Cys Ala Thr Trp Leu Asn Met Glu Val Lys Ile Ile Asp Ala Val 
                485                 490                 495     


Val Gly Glu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu Cys Asp 
            500                 505                 510         


Ser Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu Lys Arg Leu 
        515                 520                 525             


Phe Lys Leu Gly Lys Pro Leu Ala Ala Asp Asp Glu His Asp Asp Asp 
    530                 535                 540                 


Arg Arg Arg Ala Leu His Glu Glu Ser Thr Arg Trp Asn Arg Val Gly 
545                 550                 555                 560 


Ile Leu Ser Glu Leu Cys Lys Ala Val Glu Ser Arg Tyr Glu Thr Val 
                565                 570                 575     


Gly Thr Ser Ile Ile Val Met Ala Met Thr Thr Leu Ala Ser Ser Val 
            580                 585                 590         


Lys Ser Phe Ser Tyr Leu Arg Gly Ala Pro Ile Thr Leu Tyr Gly Ser 
        595                 600                 605             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    610                 615                 620                 


Pro Gly Pro 
625         


<210>  40
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, VEEV nsP4-2A-3Cpro

<400>  40

Tyr Ile Phe Ser Ser Asp Thr Gly Gln Gly His Leu Gln Gln Lys Ser 
1               5                   10                  15      


Val Arg Gln Thr Val Leu Ser Glu Val Val Leu Glu Arg Thr Glu Leu 
            20                  25                  30          


Glu Ile Ser Tyr Ala Pro Arg Leu Asp Gln Glu Lys Glu Glu Leu Leu 
        35                  40                  45              


Arg Lys Lys Leu Gln Leu Asn Pro Thr Pro Ala Asn Arg Ser Arg Tyr 
    50                  55                  60                  


Gln Ser Arg Lys Val Glu Asn Met Lys Ala Ile Thr Ala Arg Arg Ile 
65                  70                  75                  80  


Leu Gln Gly Leu Gly His Tyr Leu Lys Ala Glu Gly Lys Val Glu Cys 
                85                  90                  95      


Tyr Arg Thr Leu His Pro Val Pro Leu Tyr Ser Ser Ser Val Asn Arg 
            100                 105                 110         


Ala Phe Ser Ser Pro Lys Val Ala Val Glu Ala Cys Asn Ala Met Leu 
        115                 120                 125             


Lys Glu Asn Phe Pro Thr Val Ala Ser Tyr Cys Ile Ile Pro Glu Tyr 
    130                 135                 140                 


Asp Ala Tyr Leu Asp Met Val Asp Gly Ala Ser Cys Cys Leu Asp Thr 
145                 150                 155                 160 


Ala Ser Phe Cys Pro Ala Lys Leu Arg Ser Phe Pro Lys Lys His Ser 
                165                 170                 175     


Tyr Leu Glu Pro Thr Ile Arg Ser Ala Val Pro Ser Ala Ile Gln Asn 
            180                 185                 190         


Thr Leu Gln Asn Val Leu Ala Ala Ala Thr Lys Arg Asn Cys Asn Val 
        195                 200                 205             


Thr Gln Met Arg Glu Leu Pro Val Leu Asp Ser Ala Ala Phe Asn Val 
    210                 215                 220                 


Glu Cys Phe Lys Lys Tyr Ala Cys Asn Asn Glu Tyr Trp Glu Thr Phe 
225                 230                 235                 240 


Lys Glu Asn Pro Ile Arg Leu Thr Glu Glu Asn Val Val Asn Tyr Ile 
                245                 250                 255     


Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys Thr His 
            260                 265                 270         


Asn Leu Asn Met Leu Gln Asp Ile Pro Met Asp Arg Phe Val Met Asp 
        275                 280                 285             


Leu Lys Arg Asp Val Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu 
    290                 295                 300                 


Arg Pro Lys Val Gln Val Ile Gln Ala Ala Asp Pro Leu Ala Thr Ala 
305                 310                 315                 320 


Tyr Leu Cys Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn Ala Val 
                325                 330                 335     


Leu Leu Pro Asn Ile His Thr Leu Phe Asp Met Ser Ala Glu Asp Phe 
            340                 345                 350         


Asp Ala Ile Ile Ala Glu His Phe Gln Pro Gly Asp Cys Val Leu Glu 
        355                 360                 365             


Thr Asp Ile Ala Ser Phe Asp Lys Ser Glu Asp Asp Ala Met Ala Leu 
    370                 375                 380                 


Thr Ala Leu Met Ile Leu Glu Asp Leu Gly Val Asp Ala Glu Leu Leu 
385                 390                 395                 400 


Thr Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Ile His Leu Pro 
                405                 410                 415     


Thr Lys Thr Lys Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met Phe 
            420                 425                 430         


Leu Thr Leu Phe Val Asn Thr Val Ile Asn Ile Val Ile Ala Ser Arg 
        435                 440                 445             


Val Leu Arg Glu Arg Leu Thr Gly Ser Pro Cys Ala Ala Phe Ile Gly 
    450                 455                 460                 


Asp Asp Asn Ile Val Lys Gly Val Lys Ser Asp Lys Leu Met Ala Asp 
465                 470                 475                 480 


Arg Cys Ala Thr Trp Leu Asn Met Glu Val Lys Ile Ile Asp Ala Val 
                485                 490                 495     


Val Gly Glu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu Cys Asp 
            500                 505                 510         


Ser Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu Lys Arg Leu 
        515                 520                 525             


Phe Lys Leu Gly Lys Pro Leu Ala Ala Asp Asp Glu His Asp Asp Asp 
    530                 535                 540                 


Arg Arg Arg Ala Leu His Glu Glu Ser Thr Arg Trp Asn Arg Val Gly 
545                 550                 555                 560 


Ile Leu Ser Glu Leu Cys Lys Ala Val Glu Ser Arg Tyr Glu Thr Val 
                565                 570                 575     


Gly Thr Ser Ile Ile Val Met Ala Met Thr Thr Leu Ala Ser Ser Val 
            580                 585                 590         


Lys Ser Phe Ser Tyr Leu Arg Gly Ala Pro Ile Thr Leu Tyr Gly Ser 
        595                 600                 605             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    610                 615                 620                 


Pro Gly Pro Ser Gly Ala Pro Pro Thr Asp Leu Gln Lys Met Val Met 
625                 630                 635                 640 


Gly Asn Thr Lys Pro Val Glu Leu Ile Leu Asp Gly Lys Thr Val Ala 
                645                 650                 655     


Ile Cys Cys Ala Thr Gly Val Phe Gly Thr Ala Tyr Leu Val Pro Arg 
            660                 665                 670         


His Leu Phe Ala Glu Lys Tyr Asp Lys Ile Met Leu Asp Gly Arg Ala 
        675                 680                 685             


Met Thr Asp Ser Asp Tyr Arg Val Phe Glu Phe Glu Ile Lys Val Lys 
    690                 695                 700                 


Gly Gln Asp Met Leu Ser Asp Ala Ala Leu Met Val Leu His Arg Gly 
705                 710                 715                 720 


Asn Arg Val Arg Asp Ile Thr Lys His Phe Arg Asp Thr Ala Arg Met 
                725                 730                 735     


Lys Lys Gly Thr Pro Val Val Gly Val Val Asn Asn Ala Asp Val Gly 
            740                 745                 750         


Arg Leu Ile Phe Ser Gly Glu Ala Leu Thr Tyr Lys Asp Ile Val Val 
        755                 760                 765             


Cys Met Asp Gly Asp Thr Met Pro Ser Leu Phe Ala Tyr Lys Ala Ala 
    770                 775                 780                 


Thr Lys Ala Gly Tyr Cys Gly Gly Ala Val Leu Ala Lys Asp Gly Ala 
785                 790                 795                 800 


Asp Thr Phe Ile Val Gly Thr His Ser Ala Gly Gly Asn Gly Val Gly 
                805                 810                 815     


Tyr Cys Ser Cys Val Ser Lys Ser Met Leu Leu Arg Met Lys Ala His 
            820                 825                 830         


Val Asp Pro Glu Pro Gln His Glu 
        835                 840 


<210>  41
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, VEEV nsP4-2A-GFP

<400>  41

Tyr Ile Phe Ser Ser Asp Thr Gly Gln Gly His Leu Gln Gln Lys Ser 
1               5                   10                  15      


Val Arg Gln Thr Val Leu Ser Glu Val Val Leu Glu Arg Thr Glu Leu 
            20                  25                  30          


Glu Ile Ser Tyr Ala Pro Arg Leu Asp Gln Glu Lys Glu Glu Leu Leu 
        35                  40                  45              


Arg Lys Lys Leu Gln Leu Asn Pro Thr Pro Ala Asn Arg Ser Arg Tyr 
    50                  55                  60                  


Gln Ser Arg Lys Val Glu Asn Met Lys Ala Ile Thr Ala Arg Arg Ile 
65                  70                  75                  80  


Leu Gln Gly Leu Gly His Tyr Leu Lys Ala Glu Gly Lys Val Glu Cys 
                85                  90                  95      


Tyr Arg Thr Leu His Pro Val Pro Leu Tyr Ser Ser Ser Val Asn Arg 
            100                 105                 110         


Ala Phe Ser Ser Pro Lys Val Ala Val Glu Ala Cys Asn Ala Met Leu 
        115                 120                 125             


Lys Glu Asn Phe Pro Thr Val Ala Ser Tyr Cys Ile Ile Pro Glu Tyr 
    130                 135                 140                 


Asp Ala Tyr Leu Asp Met Val Asp Gly Ala Ser Cys Cys Leu Asp Thr 
145                 150                 155                 160 


Ala Ser Phe Cys Pro Ala Lys Leu Arg Ser Phe Pro Lys Lys His Ser 
                165                 170                 175     


Tyr Leu Glu Pro Thr Ile Arg Ser Ala Val Pro Ser Ala Ile Gln Asn 
            180                 185                 190         


Thr Leu Gln Asn Val Leu Ala Ala Ala Thr Lys Arg Asn Cys Asn Val 
        195                 200                 205             


Thr Gln Met Arg Glu Leu Pro Val Leu Asp Ser Ala Ala Phe Asn Val 
    210                 215                 220                 


Glu Cys Phe Lys Lys Tyr Ala Cys Asn Asn Glu Tyr Trp Glu Thr Phe 
225                 230                 235                 240 


Lys Glu Asn Pro Ile Arg Leu Thr Glu Glu Asn Val Val Asn Tyr Ile 
                245                 250                 255     


Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys Thr His 
            260                 265                 270         


Asn Leu Asn Met Leu Gln Asp Ile Pro Met Asp Arg Phe Val Met Asp 
        275                 280                 285             


Leu Lys Arg Asp Val Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu 
    290                 295                 300                 


Arg Pro Lys Val Gln Val Ile Gln Ala Ala Asp Pro Leu Ala Thr Ala 
305                 310                 315                 320 


Tyr Leu Cys Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn Ala Val 
                325                 330                 335     


Leu Leu Pro Asn Ile His Thr Leu Phe Asp Met Ser Ala Glu Asp Phe 
            340                 345                 350         


Asp Ala Ile Ile Ala Glu His Phe Gln Pro Gly Asp Cys Val Leu Glu 
        355                 360                 365             


Thr Asp Ile Ala Ser Phe Asp Lys Ser Glu Asp Asp Ala Met Ala Leu 
    370                 375                 380                 


Thr Ala Leu Met Ile Leu Glu Asp Leu Gly Val Asp Ala Glu Leu Leu 
385                 390                 395                 400 


Thr Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Ile His Leu Pro 
                405                 410                 415     


Thr Lys Thr Lys Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met Phe 
            420                 425                 430         


Leu Thr Leu Phe Val Asn Thr Val Ile Asn Ile Val Ile Ala Ser Arg 
        435                 440                 445             


Val Leu Arg Glu Arg Leu Thr Gly Ser Pro Cys Ala Ala Phe Ile Gly 
    450                 455                 460                 


Asp Asp Asn Ile Val Lys Gly Val Lys Ser Asp Lys Leu Met Ala Asp 
465                 470                 475                 480 


Arg Cys Ala Thr Trp Leu Asn Met Glu Val Lys Ile Ile Asp Ala Val 
                485                 490                 495     


Val Gly Glu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu Cys Asp 
            500                 505                 510         


Ser Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu Lys Arg Leu 
        515                 520                 525             


Phe Lys Leu Gly Lys Pro Leu Ala Ala Asp Asp Glu His Asp Asp Asp 
    530                 535                 540                 


Arg Arg Arg Ala Leu His Glu Glu Ser Thr Arg Trp Asn Arg Val Gly 
545                 550                 555                 560 


Ile Leu Ser Glu Leu Cys Lys Ala Val Glu Ser Arg Tyr Glu Thr Val 
                565                 570                 575     


Gly Thr Ser Ile Ile Val Met Ala Met Thr Thr Leu Ala Ser Ser Val 
            580                 585                 590         


Lys Ser Phe Ser Tyr Leu Arg Gly Ala Pro Ile Thr Leu Tyr Gly Ser 
        595                 600                 605             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    610                 615                 620                 


Pro Gly Pro Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
625                 630                 635                 640 


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
                645                 650                 655     


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
            660                 665                 670         


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
        675                 680                 685             


Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
    690                 695                 700                 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
705                 710                 715                 720 


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
                725                 730                 735     


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
            740                 745                 750         


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
        755                 760                 765             


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
    770                 775                 780                 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
785                 790                 795                 800 


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
                805                 810                 815     


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
            820                 825                 830         


Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
        835                 840                 845             


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
    850                 855                 860                 


Lys 
865 


<210>  42
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, VEEV nsP4-2A-STING

<400>  42

Tyr Ile Phe Ser Ser Asp Thr Gly Gln Gly His Leu Gln Gln Lys Ser 
1               5                   10                  15      


Val Arg Gln Thr Val Leu Ser Glu Val Val Leu Glu Arg Thr Glu Leu 
            20                  25                  30          


Glu Ile Ser Tyr Ala Pro Arg Leu Asp Gln Glu Lys Glu Glu Leu Leu 
        35                  40                  45              


Arg Lys Lys Leu Gln Leu Asn Pro Thr Pro Ala Asn Arg Ser Arg Tyr 
    50                  55                  60                  


Gln Ser Arg Lys Val Glu Asn Met Lys Ala Ile Thr Ala Arg Arg Ile 
65                  70                  75                  80  


Leu Gln Gly Leu Gly His Tyr Leu Lys Ala Glu Gly Lys Val Glu Cys 
                85                  90                  95      


Tyr Arg Thr Leu His Pro Val Pro Leu Tyr Ser Ser Ser Val Asn Arg 
            100                 105                 110         


Ala Phe Ser Ser Pro Lys Val Ala Val Glu Ala Cys Asn Ala Met Leu 
        115                 120                 125             


Lys Glu Asn Phe Pro Thr Val Ala Ser Tyr Cys Ile Ile Pro Glu Tyr 
    130                 135                 140                 


Asp Ala Tyr Leu Asp Met Val Asp Gly Ala Ser Cys Cys Leu Asp Thr 
145                 150                 155                 160 


Ala Ser Phe Cys Pro Ala Lys Leu Arg Ser Phe Pro Lys Lys His Ser 
                165                 170                 175     


Tyr Leu Glu Pro Thr Ile Arg Ser Ala Val Pro Ser Ala Ile Gln Asn 
            180                 185                 190         


Thr Leu Gln Asn Val Leu Ala Ala Ala Thr Lys Arg Asn Cys Asn Val 
        195                 200                 205             


Thr Gln Met Arg Glu Leu Pro Val Leu Asp Ser Ala Ala Phe Asn Val 
    210                 215                 220                 


Glu Cys Phe Lys Lys Tyr Ala Cys Asn Asn Glu Tyr Trp Glu Thr Phe 
225                 230                 235                 240 


Lys Glu Asn Pro Ile Arg Leu Thr Glu Glu Asn Val Val Asn Tyr Ile 
                245                 250                 255     


Thr Lys Leu Lys Gly Pro Lys Ala Ala Ala Leu Phe Ala Lys Thr His 
            260                 265                 270         


Asn Leu Asn Met Leu Gln Asp Ile Pro Met Asp Arg Phe Val Met Asp 
        275                 280                 285             


Leu Lys Arg Asp Val Lys Val Thr Pro Gly Thr Lys His Thr Glu Glu 
    290                 295                 300                 


Arg Pro Lys Val Gln Val Ile Gln Ala Ala Asp Pro Leu Ala Thr Ala 
305                 310                 315                 320 


Tyr Leu Cys Gly Ile His Arg Glu Leu Val Arg Arg Leu Asn Ala Val 
                325                 330                 335     


Leu Leu Pro Asn Ile His Thr Leu Phe Asp Met Ser Ala Glu Asp Phe 
            340                 345                 350         


Asp Ala Ile Ile Ala Glu His Phe Gln Pro Gly Asp Cys Val Leu Glu 
        355                 360                 365             


Thr Asp Ile Ala Ser Phe Asp Lys Ser Glu Asp Asp Ala Met Ala Leu 
    370                 375                 380                 


Thr Ala Leu Met Ile Leu Glu Asp Leu Gly Val Asp Ala Glu Leu Leu 
385                 390                 395                 400 


Thr Leu Ile Glu Ala Ala Phe Gly Glu Ile Ser Ser Ile His Leu Pro 
                405                 410                 415     


Thr Lys Thr Lys Phe Lys Phe Gly Ala Met Met Lys Ser Gly Met Phe 
            420                 425                 430         


Leu Thr Leu Phe Val Asn Thr Val Ile Asn Ile Val Ile Ala Ser Arg 
        435                 440                 445             


Val Leu Arg Glu Arg Leu Thr Gly Ser Pro Cys Ala Ala Phe Ile Gly 
    450                 455                 460                 


Asp Asp Asn Ile Val Lys Gly Val Lys Ser Asp Lys Leu Met Ala Asp 
465                 470                 475                 480 


Arg Cys Ala Thr Trp Leu Asn Met Glu Val Lys Ile Ile Asp Ala Val 
                485                 490                 495     


Val Gly Glu Lys Ala Pro Tyr Phe Cys Gly Gly Phe Ile Leu Cys Asp 
            500                 505                 510         


Ser Val Thr Gly Thr Ala Cys Arg Val Ala Asp Pro Leu Lys Arg Leu 
        515                 520                 525             


Phe Lys Leu Gly Lys Pro Leu Ala Ala Asp Asp Glu His Asp Asp Asp 
    530                 535                 540                 


Arg Arg Arg Ala Leu His Glu Glu Ser Thr Arg Trp Asn Arg Val Gly 
545                 550                 555                 560 


Ile Leu Ser Glu Leu Cys Lys Ala Val Glu Ser Arg Tyr Glu Thr Val 
                565                 570                 575     


Gly Thr Ser Ile Ile Val Met Ala Met Thr Thr Leu Ala Ser Ser Val 
            580                 585                 590         


Lys Ser Phe Ser Tyr Leu Arg Gly Ala Pro Ile Thr Leu Tyr Gly Ser 
        595                 600                 605             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    610                 615                 620                 


Pro Gly Pro Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg 
625                 630                 635                 640 


Gly His Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu 
                645                 650                 655     


Val Thr Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr 
            660                 665                 670         


Leu Val Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly 
        675                 680                 685             


Val Cys Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg 
    690                 695                 700                 


Gly Ser Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg 
705                 710                 715                 720 


Arg Gly Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro 
                725                 730                 735     


Asn Ala Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu 
            740                 745                 750         


Ser Gln Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala 
        755                 760                 765             


Glu Ile Ser Ala Val Cys Glu Lys Gly Asn Phe Ser Val Ala His Gly 
    770                 775                 780                 


Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu 
785                 790                 795                 800 


Leu Gln Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu 
                805                 810                 815     


Arg Gly Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys 
            820                 825                 830         


Gly Val Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu 
        835                 840                 845             


Asp Lys Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg 
    850                 855                 860                 


Val Tyr Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala 
865                 870                 875                 880 


Gly Thr Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala 
                885                 890                 895     


Met Ser Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Met Leu Glu 
            900                 905                 910         


Gln Ala Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala 
        915                 920                 925             


Pro Glu Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala 
    930                 935                 940                 


Asp Asp Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg 
945                 950                 955                 960 


Gln Glu Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala 
                965                 970                 975     


Val Pro Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser 
            980                 985                 990         


Gly Met Glu Lys Pro Leu Pro Leu  Arg Thr Asp Phe Ser  
        995                 1000                 1005 


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, thosea asigna virus 2A protein

<400>  43

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct, porcine teschovirus -1_2A protein

<400>  44

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  45
<211>  22
<212>  PRT
<213>  Foot-and-mouth disease virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  FMDV 2A protein

<400>  45

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic construct, equine rhinitis A virus 2A protein

<400>  46

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


