                               SEQUENCE LISTING

<110> TENZA, INC.
 
<120> SYNTHETIC PRE-PROTEIN SIGNAL PEPTIDES FOR DIRECTING SECRETION OF
      HETEROLOGOUS PROTEINS IN BACILLUS BACTERIA

<130> 257723.000502

<140> PCT/US2022/020905
<141> 2022-03-18

<150> 63/163,561
<151> 2021-03-19

<160> 62    

<170> PatentIn version 3.5

<210> 1
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Met Lys Lys Thr Leu Leu Leu Leu Leu Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Val Leu Ala Ala Cys Gly Ser Ala Ser Ala 
            20                  25      


<210> 2
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
atgaaaaaga ctttgttact cttactcgtc ttgttggcat ccttgctcgt tcttgctgcc       60

tgcgggagcg cctctgcc                                                     78


<210> 3
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Met Lys Lys Lys Leu Leu Leu Ala Leu Leu Leu Ser Leu Ala Leu Leu 
1               5                   10                  15      


Leu Ser Leu Ala Ala Ser Ala Ala Ser Ala Ala 
            20                  25          


<210> 4
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
atgaagaaga agctgttact tgcattactg ttatccttgg ccttgttgct gtcccttgcc       60

gcctgtagtg cagcctctgc ggca                                              84


<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Leu Glu Ile Ser Ser Thr Cys Asp Ala 
1               5                   


<210> 6
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ttggaaatct cctcaacatg cgatgcc                                           27


<210> 7
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Phe Cys Thr Phe Phe Glu Lys His His Arg Lys Trp Asp Ile Leu Leu 
1               5                   10                  15      


Glu Lys Ser Thr Gly Val Met Glu Ala 
            20                  25  


<210> 8
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ttctgtactt ttttcgagaa acatcaccgg aagtgggaca tacttttaga gaaatccact       60

ggggtgatgg aagcg                                                        75


<210> 9
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Phe Ala Lys Arg Phe Lys Thr Ser Leu Leu Pro Leu Phe Ala Gly 
1               5                   10                  15      


Phe Leu Leu Leu Phe His Leu Val Leu Ala Gly Pro Ala Ala Ala Ser 
            20                  25                  30          


Ala Glu Thr Ala 
        35      


<210> 10
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Val Ser Ile Arg Arg Ser Phe Glu Ala Tyr Val Asp Asp Met Asn 
1               5                   10                  15      


Ile Ile Thr Val Leu Ile Pro Ala Glu Gln Lys Glu Ile Met 
            20                  25                  30  


<210> 11
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Met Lys Lys Leu Leu Leu Ile Leu Leu Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Val Gly Ala Ser Ala Ala Gln 
            20              


<210> 12
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
atgaagaaga ttcttcttgg attgttggtt ctattactga tcctcttgtt agcgggctgc       60


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Met Lys Lys Leu Val Leu Ile Leu Phe Ser Ala Leu Ala Cys Ala Ala 
1               5                   10                  15      


<210> 14
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
atgaagaaac tggttcttat cttattttcc gctctggcat gtgctgcg                    48


<210> 15
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Met Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Thr Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Ser Asn Met Ser Ala Gln Ala 
            20                  25                  


<210> 16
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid except Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid except Cys

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
Lys Lys Ala Ala Ala Xaa Ala Ala Ala Ala Ala Xaa Ala Ala Trp Ala 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Lys Lys Lys Lys 
            20                  25  


<210> 17
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln Ile Pro Ala 
1               5                   10                  15      


Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe Asp Val Ala 
            20                  25                  30          


Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu Phe Ile Asn 
        35                  40                  45              


Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Asp 
    50                  55                  60                  


Lys Arg Glu Glu Gly Glu Pro Lys Ser Met Thr Asn Glu Thr Ser Asp 
65                  70                  75                  80  


Arg Pro Leu Val His Phe Thr Pro Asn Lys Gly Trp Met Asn Asp Pro 
                85                  90                  95      


Asn Gly Leu Trp Tyr Asp Glu Lys Asp Ala Lys Trp His Leu Tyr Phe 
            100                 105                 110         


Gln Tyr Asn Pro Asn Asp Thr Val Trp Gly Thr Pro Leu Phe Trp Gly 
        115                 120                 125             


His Ala Thr Ser Asp Asp Leu Thr Asn Trp Glu Asp Gln Pro Ile Ala 
    130                 135                 140                 


Ile Ala Pro Lys Arg Asn Asp Ser Gly Ala Phe Ser Gly Ser Met Val 
145                 150                 155                 160 


Val Asp Tyr Asn Asn Thr Ser Gly Phe Phe Asn Asp Thr Ile Asp Pro 
                165                 170                 175     


Arg Gln Arg Cys Val Ala Ile Trp Thr Tyr Asn Thr Pro Glu Ser Glu 
            180                 185                 190         


Glu Gln Tyr Ile Ser Tyr Ser Leu Asp Gly Gly Tyr Thr Phe Thr Glu 
        195                 200                 205             


Tyr Gln Lys Asn Pro Val Leu Ala Ala Asn Ser Thr Gln Phe Arg Asp 
    210                 215                 220                 


Pro Lys Val Phe Trp Tyr Glu Pro Ser Gln Lys Trp Ile Met Thr Ala 
225                 230                 235                 240 


Ala Lys Ser Gln Asp Tyr Lys Ile Glu Ile Tyr Ser Ser Asp Asp Leu 
                245                 250                 255     


Lys Ser Trp Lys Leu Glu Ser Ala Phe Ala Asn Glu Gly Phe Leu Gly 
            260                 265                 270         


Tyr Gln Tyr Glu Cys Pro Gly Leu Ile Glu Val Pro Thr Glu Gln Asp 
        275                 280                 285             


Pro Ser Lys Ser Tyr Trp Val Met Phe Ile Ser Ile Asn Pro Gly Ala 
    290                 295                 300                 


Pro Ala Gly Gly Ser Phe Asn Gln Tyr Phe Val Gly Ser Phe Asn Gly 
305                 310                 315                 320 


Thr His Phe Glu Ala Phe Asp Asn Gln Ser Arg Val Val Asp Phe Gly 
                325                 330                 335     


Lys Asp Tyr Tyr Ala Leu Gln Thr Phe Phe Asn Thr Asp Pro Thr Tyr 
            340                 345                 350         


Gly Ser Ala Leu Gly Ile Ala Trp Ala Ser Asn Trp Glu Tyr Ser Ala 
        355                 360                 365             


Phe Val Pro Thr Asn Pro Trp Arg Ser Ser Met Ser Leu Val Arg Lys 
    370                 375                 380                 


Phe Ser Leu Asn Thr Glu Tyr Gln Ala Asn Pro Glu Thr Glu Leu Ile 
385                 390                 395                 400 


Asn Leu Lys Ala Glu Pro Ile Leu Asn Ile Ser Asn Ala Gly Pro Trp 
                405                 410                 415     


Ser Arg Phe Ala Thr Asn Thr Thr Leu Thr Lys Ala Asn Ser Tyr Asn 
            420                 425                 430         


Val Asp Leu Ser Asn Ser Thr Gly Thr Leu Glu Phe Glu Leu Val Tyr 
        435                 440                 445             


Ala Val Asn Thr Thr Gln Thr Ile Ser Lys Ser Val Phe Ala Asp Leu 
    450                 455                 460                 


Ser Leu Trp Phe Lys Gly Leu Glu Asp Pro Glu Glu Tyr Leu Arg Met 
465                 470                 475                 480 


Gly Phe Glu Val Ser Ala Ser Ser Phe Phe Leu Asp Arg Gly Asn Ser 
                485                 490                 495     


Lys Val Lys Phe Val Lys Glu Asn Pro Tyr Phe Thr Asn Arg Met Ser 
            500                 505                 510         


Val Asn Asn Gln Pro Phe Lys Ser Glu Asn Asp Leu Ser Tyr Tyr Lys 
        515                 520                 525             


Val Tyr Gly Leu Leu Asp Gln Asn Ile Leu Glu Leu Tyr Phe Asn Asp 
    530                 535                 540                 


Gly Asp Val Val Ser Thr Asn Thr Tyr Phe Met Thr Thr Gly Asn Ala 
545                 550                 555                 560 


Leu Gly Ser Val Asn Met Thr Thr Gly Val Asp Asn Leu Phe Tyr Ile 
                565                 570                 575     


Asp Lys Phe Gln Val Arg Glu Val Lys 
            580                 585 


<210> 18
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ser Met Thr Asn Glu Thr Ser Asp Arg Pro Leu Val His Phe Thr Pro 
1               5                   10                  15      


Asn Lys Gly Trp Met Asn Asp Pro Asn Gly Leu Trp Tyr Asp Glu Lys 
            20                  25                  30          


Asp Ala Lys Trp His Leu Tyr Phe Gln Tyr Asn Pro Asn Asp Thr Val 
        35                  40                  45              


Trp Gly Thr Pro Leu Phe Trp Gly His Ala Thr Ser Asp Asp Leu Thr 
    50                  55                  60                  


Asn Trp Glu Asp Gln Pro Ile Ala Ile Ala Pro Lys Arg Asn Asp Ser 
65                  70                  75                  80  


Gly Ala Phe Ser Gly Ser Met Val Val Asp Tyr Asn Asn Thr Ser Gly 
                85                  90                  95      


Phe Phe Asn Asp Thr Ile Asp Pro Arg Gln Arg Cys Val Ala Ile Trp 
            100                 105                 110         


Thr Tyr Asn Thr Pro Glu Ser Glu Glu Gln Tyr Ile Ser Tyr Ser Leu 
        115                 120                 125             


Asp Gly Gly Tyr Thr Phe Thr Glu Tyr Gln Lys Asn Pro Val Leu Ala 
    130                 135                 140                 


Ala Asn Ser Thr Gln Phe Arg Asp Pro Lys Val Phe Trp Tyr Glu Pro 
145                 150                 155                 160 


Ser Gln Lys Trp Ile Met Thr Ala Ala Lys Ser Gln Asp Tyr Lys Ile 
                165                 170                 175     


Glu Ile Tyr Ser Ser Asp Asp Leu Lys Ser Trp Lys Leu Glu Ser Ala 
            180                 185                 190         


Phe Ala Asn Glu Gly Phe Leu Gly Tyr Gln Tyr Glu Cys Pro Gly Leu 
        195                 200                 205             


Ile Glu Val Pro Thr Glu Gln Asp Pro Ser Lys Ser Tyr Trp Val Met 
    210                 215                 220                 


Phe Ile Ser Ile Asn Pro Gly Ala Pro Ala Gly Gly Ser Phe Asn Gln 
225                 230                 235                 240 


Tyr Phe Val Gly Ser Phe Asn Gly Thr His Phe Glu Ala Phe Asp Asn 
                245                 250                 255     


Gln Ser Arg Val Val Asp Phe Gly Lys Asp Tyr Tyr Ala Leu Gln Thr 
            260                 265                 270         


Phe Phe Asn Thr Asp Pro Thr Tyr Gly Ser Ala Leu Gly Ile Ala Trp 
        275                 280                 285             


Ala Ser Asn Trp Glu Tyr Ser Ala Phe Val Pro Thr Asn Pro Trp Arg 
    290                 295                 300                 


Ser Ser Met Ser Leu Val Arg Lys Phe Ser Leu Asn Thr Glu Tyr Gln 
305                 310                 315                 320 


Ala Asn Pro Glu Thr Glu Leu Ile Asn Leu Lys Ala Glu Pro Ile Leu 
                325                 330                 335     


Asn Ile Ser Asn Ala Gly Pro Trp Ser Arg Phe Ala Thr Asn Thr Thr 
            340                 345                 350         


Leu Thr Lys Ala Asn Ser Tyr Asn Val Asp Leu Ser Asn Ser Thr Gly 
        355                 360                 365             


Thr Leu Glu Phe Glu Leu Val Tyr Ala Val Asn Thr Thr Gln Thr Ile 
    370                 375                 380                 


Ser Lys Ser Val Phe Ala Asp Leu Ser Leu Trp Phe Lys Gly Leu Glu 
385                 390                 395                 400 


Asp Pro Glu Glu Tyr Leu Arg Met Gly Phe Glu Val Ser Ala Ser Ser 
                405                 410                 415     


Phe Phe Leu Asp Arg Gly Asn Ser Lys Val Lys Phe Val Lys Glu Asn 
            420                 425                 430         


Pro Tyr Phe Thr Asn Arg Met Ser Val Asn Asn Gln Pro Phe Lys Ser 
        435                 440                 445             


Glu Asn Asp Leu Ser Tyr Tyr Lys Val Tyr Gly Leu Leu Asp Gln Asn 
    450                 455                 460                 


Ile Leu Glu Leu Tyr Phe Asn Asp Gly Asp Val Val Ser Thr Asn Thr 
465                 470                 475                 480 


Tyr Phe Met Thr Thr Gly Asn Ala Leu Gly Ser Val Asn Met Thr Thr 
                485                 490                 495     


Gly Val Asp Asn Leu Phe Tyr Ile Asp Lys Phe Gln Val Arg Glu Val 
            500                 505                 510         


Lys 
    


<210> 19
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly 
1               5                   10                  15      


Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala 
            20                  25                  30          


Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly 
        35                  40                  45              


Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp 
    50                  55                  60                  


Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys Gln Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala 
                85                  90                  95      


Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp 
            100                 105                 110         


Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys 
        115                 120                 125             


Gly Val 
    130 


<210> 20
<211> 985
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Ile Lys His Arg Leu Asn Gly Phe Thr Ile Leu Glu His Pro Asp Pro 
1               5                   10                  15      


Ala Lys Arg Asp Leu Leu Gln Asp Ile Val Thr Trp Asp Asp Lys Ser 
            20                  25                  30          


Leu Phe Ile Asn Gly Glu Arg Ile Met Leu Phe Ser Gly Glu Val His 
        35                  40                  45              


Pro Phe Arg Leu Pro Val Pro Ser Leu Trp Leu Asp Ile Phe His Lys 
    50                  55                  60                  


Ile Arg Ala Leu Gly Phe Asn Cys Val Ser Phe Tyr Ile Asp Trp Ala 
65                  70                  75                  80  


Leu Leu Glu Gly Lys Pro Gly Asp Tyr Arg Ala Glu Gly Ile Phe Ala 
                85                  90                  95      


Leu Glu Pro Phe Phe Asp Ala Ala Lys Glu Ala Gly Ile Tyr Leu Ile 
            100                 105                 110         


Ala Arg Pro Gly Ser Tyr Ile Asn Ala Glu Val Ser Gly Gly Gly Phe 
        115                 120                 125             


Pro Gly Trp Leu Gln Arg Val Asn Gly Thr Leu Arg Ser Ser Asp Glu 
    130                 135                 140                 


Pro Phe Leu Lys Ala Thr Asp Asn Tyr Ile Ala Asn Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Lys Ala Gln Ile Thr Asn Gly Gly Pro Val Ile Leu Tyr Gln 
                165                 170                 175     


Pro Glu Asn Glu Tyr Ser Gly Gly Cys Cys Gly Val Lys Tyr Pro Asp 
            180                 185                 190         


Ala Asp Tyr Met Gln Tyr Val Met Asp Gln Ala Arg Lys Ala Asp Ile 
        195                 200                 205             


Val Val Pro Phe Ile Ser Asn Asp Ala Ser Pro Ser Gly His Asn Ala 
    210                 215                 220                 


Pro Gly Ser Gly Thr Ser Ala Val Asp Ile Tyr Gly His Asp Ser Tyr 
225                 230                 235                 240 


Pro Leu Gly Phe Asp Cys Ala Asn Pro Ser Val Trp Pro Glu Gly Lys 
                245                 250                 255     


Leu Pro Asp Asn Phe Arg Thr Leu His Leu Glu Gln Ser Pro Ser Thr 
            260                 265                 270         


Pro Tyr Ser Leu Leu Glu Phe Gln Ala Gly Ala Phe Asp Pro Trp Gly 
        275                 280                 285             


Gly Pro Gly Phe Glu Lys Cys Tyr Ala Leu Val Asn His Glu Phe Ser 
    290                 295                 300                 


Arg Val Phe Tyr Arg Asn Asp Leu Ser Phe Gly Val Ser Thr Phe Asn 
305                 310                 315                 320 


Leu Tyr Met Thr Phe Gly Gly Thr Asn Trp Gly Asn Leu Gly His Pro 
                325                 330                 335     


Gly Gly Tyr Thr Ser Tyr Asp Tyr Gly Ser Pro Ile Thr Glu Thr Arg 
            340                 345                 350         


Asn Val Thr Arg Glu Lys Tyr Ser Asp Ile Lys Leu Leu Ala Asn Phe 
        355                 360                 365             


Val Lys Ala Ser Pro Ser Tyr Leu Thr Ala Thr Pro Arg Asn Leu Thr 
    370                 375                 380                 


Thr Gly Val Tyr Thr Asp Thr Ser Asp Leu Ala Val Thr Pro Leu Ile 
385                 390                 395                 400 


Gly Asp Ser Pro Gly Ser Phe Phe Val Val Arg His Thr Asp Tyr Ser 
                405                 410                 415     


Ser Gln Glu Ser Thr Ser Tyr Lys Leu Lys Leu Pro Thr Ser Ala Gly 
            420                 425                 430         


Asn Leu Thr Ile Pro Gln Leu Glu Gly Thr Leu Ser Leu Asn Gly Arg 
        435                 440                 445             


Asp Ser Lys Ile His Val Val Asp Tyr Asn Val Ser Gly Thr Asn Ile 
    450                 455                 460                 


Ile Tyr Ser Thr Ala Glu Val Phe Thr Trp Lys Lys Phe Asp Gly Asn 
465                 470                 475                 480 


Lys Val Leu Val Leu Tyr Gly Gly Pro Lys Glu His His Glu Leu Ala 
                485                 490                 495     


Ile Ala Ser Lys Ser Asn Val Thr Ile Ile Glu Gly Ser Asp Ser Gly 
            500                 505                 510         


Ile Val Ser Thr Arg Lys Gly Ser Ser Val Ile Ile Gly Trp Asp Val 
        515                 520                 525             


Ser Ser Thr Arg Arg Ile Val Gln Val Gly Asp Leu Arg Val Phe Leu 
    530                 535                 540                 


Leu Asp Arg Asn Ser Ala Tyr Asn Tyr Trp Val Pro Glu Leu Pro Thr 
545                 550                 555                 560 


Glu Gly Thr Ser Pro Gly Phe Ser Thr Ser Lys Thr Thr Ala Ser Ser 
                565                 570                 575     


Ile Ile Val Lys Ala Gly Tyr Leu Leu Arg Gly Ala His Leu Asp Gly 
            580                 585                 590         


Ala Asp Leu His Leu Thr Ala Asp Phe Asn Ala Thr Thr Pro Ile Glu 
        595                 600                 605             


Val Ile Gly Ala Pro Thr Gly Ala Lys Asn Leu Phe Val Asn Gly Glu 
    610                 615                 620                 


Lys Ala Ser His Thr Val Asp Lys Asn Gly Ile Trp Ser Ser Glu Val 
625                 630                 635                 640 


Lys Tyr Ala Ala Pro Glu Ile Lys Leu Pro Gly Leu Lys Asp Leu Asp 
                645                 650                 655     


Trp Lys Tyr Leu Asp Thr Leu Pro Glu Ile Lys Ser Ser Tyr Asp Asp 
            660                 665                 670         


Ser Ala Trp Val Ser Ala Asp Leu Pro Lys Thr Lys Asn Thr His Arg 
        675                 680                 685             


Pro Leu Asp Thr Pro Thr Ser Leu Tyr Ser Ser Asp Tyr Gly Phe His 
    690                 695                 700                 


Thr Gly Tyr Leu Ile Tyr Arg Gly His Phe Val Ala Asn Gly Lys Glu 
705                 710                 715                 720 


Ser Glu Phe Phe Ile Arg Thr Gln Gly Gly Ser Ala Phe Gly Ser Ser 
                725                 730                 735     


Val Trp Leu Asn Glu Thr Tyr Leu Gly Ser Trp Thr Gly Ala Asp Tyr 
            740                 745                 750         


Ala Met Asp Gly Asn Ser Thr Tyr Lys Leu Ser Gln Leu Glu Ser Gly 
        755                 760                 765             


Lys Asn Tyr Val Ile Thr Val Val Ile Asp Asn Leu Gly Leu Asp Glu 
    770                 775                 780                 


Asn Trp Thr Val Gly Glu Glu Thr Met Lys Asn Pro Arg Gly Ile Leu 
785                 790                 795                 800 


Ser Tyr Lys Leu Ser Gly Gln Asp Ala Ser Ala Ile Thr Trp Lys Leu 
                805                 810                 815     


Thr Gly Asn Leu Gly Gly Glu Asp Tyr Gln Asp Lys Val Arg Gly Pro 
            820                 825                 830         


Leu Asn Glu Gly Gly Leu Tyr Ala Glu Arg Gln Gly Phe His Gln Pro 
        835                 840                 845             


Gln Pro Pro Ser Glu Ser Trp Glu Ser Gly Ser Pro Leu Glu Gly Leu 
    850                 855                 860                 


Ser Lys Pro Gly Ile Gly Phe Tyr Thr Ala Gln Phe Asp Leu Asp Leu 
865                 870                 875                 880 


Pro Lys Gly Trp Asp Val Pro Leu Tyr Phe Asn Phe Gly Asn Asn Thr 
                885                 890                 895     


Gln Ala Ala Arg Ala Gln Leu Tyr Val Asn Gly Tyr Gln Tyr Gly Lys 
            900                 905                 910         


Phe Thr Gly Asn Val Gly Pro Gln Thr Ser Phe Pro Val Pro Glu Gly 
        915                 920                 925             


Ile Leu Asn Tyr Arg Gly Thr Asn Tyr Val Ala Leu Ser Leu Trp Ala 
    930                 935                 940                 


Leu Glu Ser Asp Gly Ala Lys Leu Gly Ser Phe Glu Leu Ser Tyr Thr 
945                 950                 955                 960 


Thr Pro Val Leu Thr Gly Tyr Gly Asn Val Glu Ser Pro Glu Gln Pro 
                965                 970                 975     


Lys Tyr Glu Gln Arg Lys Gly Ala Tyr 
            980                 985 


<210> 21
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr Lys Tyr Pro Asp Ser Val 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Pro Ser Gly Phe Asn Arg Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 22
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr 
1               5                   10                  15      


Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile 
            20                  25                  30          


Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln 
        35                  40                  45              


Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp 
    50                  55                  60                  


Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro 
65                  70                  75                  80  


Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val 
                85                  90                  95      


Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu 
            100                 105                 110         


Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp 
        115                 120                 125             


Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser 
    130                 135                 140                 


Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile 
145                 150                 155                 160 


Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp 
                165                 170                 175     


Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr 
            180                 185                 190         


Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
        195                 200                 205             


Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr 
    210                 215                 220                 


Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn 
225                 230                 235                 240 


Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro 
                245                 250                 255     


Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys 
            260                 265                 270         


Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly 
        275                 280                 285             


Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys 
    290                 295                 300                 


Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met 
305                 310                 315                 320 


Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser 
                325                 330                 335     


Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly 
            340                 345                 350         


Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Arg Ile Thr 
        355                 360                 365             


Lys 
    


<210> 23
<211> 411
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Ala Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser 
1               5                   10                  15      


Arg His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp 
            20                  25                  30          


Val Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu 
        35                  40                  45              


Thr Pro Arg Gly Gly Glu Leu Leu Ala Tyr Leu Gly His Tyr Trp Arg 
    50                  55                  60                  


Gln Arg Leu Val Ala Asp Gly Leu Leu Pro Lys Cys Gly Cys Pro Gln 
65                  70                  75                  80  


Ser Gly Gln Val Ala Ile Leu Ala Asp Val Asp Glu Arg Thr Arg Lys 
                85                  90                  95      


Thr Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr 
            100                 105                 110         


Val His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro 
        115                 120                 125             


Leu Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala 
    130                 135                 140                 


Ile Leu Glu Arg Ala Gly Gly Ser Leu Ala Asp Phe Thr Gly His Tyr 
145                 150                 155                 160 


Gln Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser 
                165                 170                 175     


Asn Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr 
            180                 185                 190         


Gln Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Cys Val Ser Leu 
        195                 200                 205             


Thr Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu 
    210                 215                 220                 


Gln Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp 
225                 230                 235                 240 


Ser His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp 
                245                 250                 255     


Leu Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu 
            260                 265                 270         


Leu Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln 
        275                 280                 285             


Ala Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Leu Ala Gly His 
    290                 295                 300                 


Asp Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr 
305                 310                 315                 320 


Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe 
                325                 330                 335     


Glu Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser 
            340                 345                 350         


Leu Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser 
        355                 360                 365             


Leu Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu 
    370                 375                 380                 


Glu Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile 
385                 390                 395                 400 


Val Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410     


<210> 24
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Glu Trp Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn 
    50              


<210> 25
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Thr Lys Ala Ala Arg Ser Ile Arg Ala Gln Arg His Thr Asp 
65                  70                  75                  80  


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Thr Ser Arg Gly 
                85                  90                  95      


Ser Ala Gly Asn Lys Thr Tyr Arg Met 
            100                 105 


<210> 26
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly 
1               5                   10                  15      


Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala 
            20                  25                  30          


Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly 
        35                  40                  45              


Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp 
    50                  55                  60                  


Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys Gln Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala 
                85                  90                  95      


Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp 
            100                 105                 110         


Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys 
        115                 120                 125             


Gly Val 
    130 


<210> 27
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Lys Arg Ser Ile Ser Ile Phe Ile Thr Cys Leu Leu Ile Thr Leu 
1               5                   10                  15      


Leu Thr Met Gly Gly Met Ile Ala Ser Pro Ala Ser Ala Ala Gly Thr 
            20                  25                  30          


Lys Thr Pro Val Ala Lys Asn Gly Gln Leu Ser Ile Lys Gly Thr Gln 
        35                  40                  45              


Leu Val Asn Arg Asp Gly Lys Ala Val Gln Leu Lys Gly Ile Ser Ser 
    50                  55                  60                  


His Gly Leu Gln Trp Tyr Gly Glu Tyr Val Asn Lys Asp Ser Leu Lys 
65                  70                  75                  80  


Trp Leu Arg Asp Asp Trp Gly Ile Thr Val Phe Arg Ala Ala Met Tyr 
                85                  90                  95      


Thr Ala Asp Gly Gly Tyr Ile Asp Asn Pro Ser Val Lys Asn Lys Val 
            100                 105                 110         


Lys Glu Ala Val Glu Ala Ala Lys Glu Leu Gly Ile Tyr Val Ile Ile 
        115                 120                 125             


Asp Trp His Ile Leu Asn Asp Gly Asn Pro Asn Gln Asn Lys Glu Lys 
    130                 135                 140                 


Ala Lys Glu Phe Phe Lys Glu Met Ser Ser Leu Tyr Gly Asn Thr Pro 
145                 150                 155                 160 


Asn Val Ile Tyr Glu Ile Ala Asn Glu Pro Asn Gly Asp Val Asn Trp 
                165                 170                 175     


Lys Arg Asp Ile Lys Pro Tyr Ala Glu Glu Val Ile Ser Val Ile Arg 
            180                 185                 190         


Lys Asn Asp Pro Asp Asn Ile Ile Ile Val Gly Thr Gly Thr Trp Ser 
        195                 200                 205             


Gln Asp Val Asn Asp Ala Ala Asp Asp Gln Leu Lys Asp Ala Asn Val 
    210                 215                 220                 


Met Tyr Ala Leu His Phe Tyr Ala Gly Thr His Gly Gln Phe Leu Arg 
225                 230                 235                 240 


Asp Lys Ala Asn Tyr Ala Leu Ser Lys Gly Ala Pro Ile Phe Val Thr 
                245                 250                 255     


Glu Trp Gly Thr Ser Asp Ala Ser Gly Asn Gly Gly Val Phe Leu Asp 
            260                 265                 270         


Gln Ser Arg Glu Trp Leu Lys Tyr Leu Asp Ser Lys Thr Ile Ser Trp 
        275                 280                 285             


Val Asn Trp Asn Leu Ser Asp Lys Gln Glu Ser Ser Ser Ala Leu Lys 
    290                 295                 300                 


Pro Gly Ala Ser Lys Thr Gly Gly Trp Arg Leu Ser Asp Leu Ser Ala 
305                 310                 315                 320 


Ser Gly Thr Phe Val Arg Glu Asn Ile Leu Gly Thr Lys Asp Ser Thr 
                325                 330                 335     


Lys Asp Ile Pro Glu Thr Pro Ser Lys Asp Lys Pro Thr Gln Glu Asn 
            340                 345                 350         


Gly Ile Ser Val Gln Tyr Arg Ala Gly Asp Gly Ser Met Asn Ser Asn 
        355                 360                 365             


Gln Ile Arg Pro Gln Leu Gln Ile Lys Asn Asn Gly Asn Thr Thr Val 
    370                 375                 380                 


Asp Leu Lys Asp Val Thr Ala Arg Tyr Trp Tyr Lys Ala Lys Asn Lys 
385                 390                 395                 400 


Gly Gln Asn Phe Asp Cys Asp Tyr Ala Gln Ile Gly Cys Gly Asn Val 
                405                 410                 415     


Thr His Lys Phe Val Thr Leu His Lys Pro Lys Gln Gly Ala Asp Thr 
            420                 425                 430         


Tyr Leu Glu Leu Gly Phe Lys Asn Gly Thr Leu Ala Pro Gly Ala Ser 
        435                 440                 445             


Thr Gly Asn Ile Gln Leu Arg Leu His Asn Asp Asp Trp Ser Asn Tyr 
    450                 455                 460                 


Ala Gln Ser Gly Asp Tyr Ser Phe Phe Lys Ser Asn Thr Phe Lys Thr 
465                 470                 475                 480 


Thr Lys Lys Ile Thr Leu Tyr Asp Gln Gly Lys Leu Ile Trp Gly Thr 
                485                 490                 495     


Glu Pro Asn 
            


<210> 28
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Lys Gln Gln Lys Arg Leu Tyr Ala Arg Leu Leu Thr Leu Leu Phe 
1               5                   10                  15      


Ala Leu Ile Phe Leu Leu Pro His Ser Ala Ala Ala Ala Ala Asn Leu 
            20                  25                  30          


Asn Gly Thr Leu Met Gln Tyr Phe Glu Trp Tyr Met Pro Asn Asp Gly 
        35                  40                  45              


Gln His Trp Lys Arg Leu Gln Asn Asp Ser Ala Tyr Leu Ala Glu His 
    50                  55                  60                  


Gly Ile Thr Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln 
65                  70                  75                  80  


Ala Asp Val Gly Tyr Gly Ala Tyr Asp Leu Tyr Asp Leu Gly Glu Phe 
                85                  90                  95      


His Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Thr Lys Gly Glu Leu 
            100                 105                 110         


Gln Ser Ala Ile Lys Ser Leu His Ser Arg Asp Ile Asn Val Tyr Gly 
        115                 120                 125             


Asp Val Val Ile Asn His Lys Gly Gly Ala Asp Ala Thr Glu Asp Val 
    130                 135                 140                 


Thr Ala Val Glu Val Asp Pro Ala Asp Arg Asn Arg Val Ile Ser Gly 
145                 150                 155                 160 


Glu His Arg Ile Lys Ala Trp Thr His Phe His Phe Pro Gly Arg Gly 
                165                 170                 175     


Ser Thr Tyr Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr 
            180                 185                 190         


Asp Trp Asp Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Gln Gly 
        195                 200                 205             


Lys Ala Trp Asp Trp Glu Val Ser Asn Glu Asn Gly Asn Tyr Asp Tyr 
    210                 215                 220                 


Leu Met Tyr Ala Asp Ile Asp Tyr Asp His Pro Asp Val Ala Ala Glu 
225                 230                 235                 240 


Ile Lys Arg Trp Gly Thr Trp Tyr Ala Asn Glu Leu Gln Leu Asp Gly 
                245                 250                 255     


Phe Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe Leu Arg Asp 
            260                 265                 270         


Trp Val Asn His Val Arg Glu Lys Thr Gly Lys Glu Met Phe Thr Val 
        275                 280                 285             


Ala Glu Tyr Trp Gln Asn Asp Leu Gly Ala Leu Glu Asn Tyr Leu Asn 
    290                 295                 300                 


Lys Thr Asn Phe Asn His Ser Val Phe Asp Val Pro Leu His Tyr Gln 
305                 310                 315                 320 


Phe His Ala Ala Ser Thr Gln Gly Gly Gly Tyr Asp Met Arg Lys Leu 
                325                 330                 335     


Leu Asn Ser Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe 
            340                 345                 350         


Val Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val 
        355                 360                 365             


Gln Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu 
    370                 375                 380                 


Ser Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly 
385                 390                 395                 400 


Asp Ser Gln Arg Glu Ile Pro Ala Leu Lys His Lys Ile Glu Pro Ile 
                405                 410                 415     


Leu Lys Ala Arg Lys Gln Tyr Ala Tyr Gly Ala Gln His Asp Tyr Phe 
            420                 425                 430         


Asp His His Asp Ile Val Gly Trp Thr Arg Glu Gly Asp Ser Ser Val 
        435                 440                 445             


Ala Asn Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ala 
    450                 455                 460                 


Lys Arg Met Tyr Val Gly Arg Gln Asn Ala Gly Glu Thr Trp His Asp 
465                 470                 475                 480 


Ile Thr Gly Asn Arg Ser Glu Pro Val Val Ile Asn Ser Glu Gly Trp 
                485                 490                 495     


Gly Glu Phe His Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510         


<210> 29
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Phe Lys Phe Lys Lys Asn Phe Leu Val Gly Leu Ser Ala Ala Leu 
1               5                   10                  15      


Met Ser Ile Ser Leu Phe Ser Ala Thr Ala Ser Ala Ala Ser Thr Asp 
            20                  25                  30          


Tyr Trp Gln Asn Trp Thr Asp Gly Gly Gly Ile Val Asn Ala Val Asn 
        35                  40                  45              


Gly Ser Gly Gly Asn Tyr Ser Val Asn Trp Ser Asn Thr Gly Asn Phe 
    50                  55                  60                  


Val Val Gly Lys Gly Trp Thr Thr Gly Ser Pro Phe Arg Thr Ile Asn 
65                  70                  75                  80  


Tyr Asn Ala Gly Val Trp Ala Pro Asn Gly Asn Gly Tyr Leu Thr Leu 
                85                  90                  95      


Tyr Gly Trp Thr Arg Ser Pro Leu Ile Glu Tyr Tyr Val Val Asp Ser 
            100                 105                 110         


Trp Gly Thr Tyr Arg Pro Thr Gly Thr Tyr Lys Gly Thr Val Lys Ser 
        115                 120                 125             


Asp Gly Gly Thr Tyr Asp Ile Tyr Thr Thr Thr Arg Tyr Asn Ala Pro 
    130                 135                 140                 


Ser Ile Asp Gly Asp Arg Thr Thr Phe Thr Gln Tyr Trp Ser Val Arg 
145                 150                 155                 160 


Gln Ser Lys Arg Pro Thr Gly Ser Asn Ala Thr Ile Thr Phe Ser Asn 
                165                 170                 175     


His Val Asn Ala Trp Lys Ser His Gly Met Asn Leu Gly Ser Asn Trp 
            180                 185                 190         


Ala Tyr Gln Val Met Ala Thr Glu Gly Tyr Gln Ser Ser Gly Ser Ser 
        195                 200                 205             


Asn Val Thr Val Trp 
    210             


<210> 30
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Pro Tyr Leu Lys Arg Val Leu Leu Leu Leu Val Thr Gly Leu Phe 
1               5                   10                  15      


Met Ser Leu Phe Ala Val Thr Ala Thr Ala Ser Ala Gln Thr Gly Gly 
            20                  25                  30          


Ser Phe Phe Asp Pro Phe Asn Gly Tyr Asn Ser Gly Phe Trp Gln Lys 
        35                  40                  45              


Ala Asp Gly Tyr Ser Asn Gly Asn Met Phe Asn Cys Thr Trp Arg Ala 
    50                  55                  60                  


Asn Asn Val Ser Met Thr Ser Leu Gly Glu Met Arg Leu Ala Leu Thr 
65                  70                  75                  80  


Ser Pro Ala Tyr Asn Lys Phe Asp Cys Gly Glu Asn Arg Ser Val Gln 
                85                  90                  95      


Thr Tyr Gly Tyr Gly Leu Tyr Glu Val Arg Met Lys Pro Ala Lys Asn 
            100                 105                 110         


Thr Gly Ile Val Ser Ser Phe Phe Thr Tyr Thr Gly Pro Thr Asp Gly 
        115                 120                 125             


Thr Pro Trp Asp Glu Ile Asp Ile Glu Phe Leu Gly Lys Asp Thr Thr 
    130                 135                 140                 


Lys Val Gln Phe Asn Tyr Tyr Thr Asn Gly Ala Gly Asn His Glu Lys 
145                 150                 155                 160 


Ile Val Asp Leu Gly Phe Asp Ala Ala Asn Ala Tyr His Thr Tyr Ala 
                165                 170                 175     


Phe Asp Trp Gln Pro Asn Ser Ile Lys Trp Tyr Val Asp Gly Gln Leu 
            180                 185                 190         


Lys His Thr Ala Thr Asn Gln Ile Pro Thr Thr Pro Gly Lys Ile Met 
        195                 200                 205             


Met Asn Leu Trp Asn Gly Thr Gly Val Asp Glu Trp Leu Gly Ser Tyr 
    210                 215                 220                 


Asn Gly Val Asn Pro Leu Tyr Ala His Tyr Asp Trp Val Arg Tyr Thr 
225                 230                 235                 240 


Lys Lys 
        


<210> 31
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Lys Phe Val Lys Arg Arg Ile Ile Ala Leu Val Thr Ile Leu Met 
1               5                   10                  15      


Leu Ser Val Thr Ser Leu Phe Ala Leu Gln Pro Ser Ala Lys Ala Ala 
            20                  25                  30          


Glu His Asn Pro Val Val Met Val His Gly Ile Gly Gly Ala Ser Phe 
        35                  40                  45              


Asn Phe Ala Gly Ile Lys Ser Tyr Leu Val Ser Gln Gly Trp Ser Arg 
    50                  55                  60                  


Asp Lys Leu Tyr Ala Val Asp Phe Trp Asp Lys Thr Gly Thr Asn Tyr 
65                  70                  75                  80  


Asn Asn Gly Pro Val Leu Ser Arg Phe Val Gln Lys Val Leu Asp Glu 
                85                  90                  95      


Thr Gly Ala Lys Lys Val Asp Ile Val Ala His Ser Met Gly Gly Ala 
            100                 105                 110         


Asn Thr Leu Tyr Tyr Ile Lys Asn Leu Asp Gly Gly Asn Lys Val Ala 
        115                 120                 125             


Asn Val Val Thr Leu Gly Gly Ala Asn Arg Leu Thr Thr Gly Lys Ala 
    130                 135                 140                 


Leu Pro Gly Thr Asp Pro Asn Gln Lys Ile Leu Tyr Thr Ser Ile Tyr 
145                 150                 155                 160 


Ser Ser Ala Asp Met Ile Val Met Asn Tyr Leu Ser Arg Leu Asp Gly 
                165                 170                 175     


Ala Arg Asn Val Gln Ile His Gly Val Gly His Ile Gly Leu Leu Tyr 
            180                 185                 190         


Ser Ser Gln Val Asn Ser Leu Ile Lys Glu Gly Leu Asn Gly Gly Gly 
        195                 200                 205             


Gln Asn Thr Asn 
    210         


<210> 32
<211> 341
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Lys Lys Leu Ile Ser Ile Ile Phe Ile Phe Val Leu Gly Val Val 
1               5                   10                  15      


Gly Ser Leu Thr Ala Ala Val Ser Ala Glu Ala Ala Ser Ala Leu Asn 
            20                  25                  30          


Ser Gly Lys Val Asn Pro Leu Ala Asp Phe Ser Leu Lys Gly Phe Ala 
        35                  40                  45              


Ala Leu Asn Gly Gly Thr Thr Gly Gly Glu Gly Gly Gln Thr Val Thr 
    50                  55                  60                  


Val Thr Thr Gly Asp Gln Leu Ile Ala Ala Leu Lys Asn Lys Asn Ala 
65                  70                  75                  80  


Asn Thr Pro Leu Lys Ile Tyr Val Asn Gly Thr Ile Thr Thr Ser Asn 
                85                  90                  95      


Thr Ser Ala Ser Lys Ile Asp Val Lys Asp Val Ser Asn Val Ser Ile 
            100                 105                 110         


Val Gly Ser Gly Thr Lys Gly Glu Leu Lys Gly Ile Gly Ile Lys Ile 
        115                 120                 125             


Trp Arg Ala Asn Asn Ile Ile Ile Arg Asn Leu Lys Ile His Glu Val 
    130                 135                 140                 


Ala Ser Gly Asp Lys Asp Ala Ile Gly Ile Glu Gly Pro Ser Lys Asn 
145                 150                 155                 160 


Ile Trp Val Asp His Asn Glu Leu Tyr His Ser Leu Asn Val Asp Lys 
                165                 170                 175     


Asp Tyr Tyr Asp Gly Leu Phe Asp Val Lys Arg Asp Ala Glu Tyr Ile 
            180                 185                 190         


Thr Phe Ser Trp Asn Tyr Val His Asp Gly Trp Lys Ser Met Leu Met 
        195                 200                 205             


Gly Ser Ser Asp Ser Asp Asn Tyr Asn Arg Thr Ile Thr Phe His His 
    210                 215                 220                 


Asn Trp Phe Glu Asn Leu Asn Ser Arg Val Pro Ser Phe Arg Phe Gly 
225                 230                 235                 240 


Glu Gly His Ile Tyr Asn Asn Tyr Phe Asn Lys Ile Ile Asp Ser Gly 
                245                 250                 255     


Ile Asn Ser Arg Met Gly Ala Arg Ile Arg Ile Glu Asn Asn Leu Phe 
            260                 265                 270         


Glu Asn Ala Lys Asp Pro Ile Val Ser Trp Tyr Ser Ser Ser Pro Gly 
        275                 280                 285             


Tyr Trp His Val Ser Asn Asn Lys Phe Val Asn Ser Arg Gly Ser Met 
    290                 295                 300                 


Pro Thr Thr Ser Thr Thr Thr Tyr Asn Pro Pro Tyr Ser Tyr Ser Leu 
305                 310                 315                 320 


Asp Asn Val Asp Asn Val Lys Ser Ile Val Lys Gln Asn Ala Gly Val 
                325                 330                 335     


Gly Lys Ile Asn Pro 
            340     


<210> 33
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Lys Asn Val Lys Lys Arg Val Gly Val Val Leu Leu Ile Leu Ala 
1               5                   10                  15      


Val Leu Gly Val Tyr Met Leu Ala Met Pro Ala Asn Thr Val Ser Ala 
            20                  25                  30          


Ala Gly Val Pro Phe Asn Thr Lys Tyr Pro Tyr Gly Pro Thr Ser Ile 
        35                  40                  45              


Ala Asp Asn Gln Ser Glu Val Thr Ala Met Leu Lys Ala Glu Trp Glu 
    50                  55                  60                  


Asp Trp Lys Ser Lys Arg Ile Thr Ser Asn Gly Ala Gly Gly Tyr Lys 
65                  70                  75                  80  


Arg Val Gln Arg Asp Ala Ser Thr Asn Tyr Asp Thr Val Ser Glu Gly 
                85                  90                  95      


Met Gly Tyr Gly Leu Leu Leu Ala Val Cys Phe Asn Glu Gln Ala Leu 
            100                 105                 110         


Phe Asp Asp Leu Tyr Arg Tyr Val Lys Ser His Phe Asn Gly Asn Gly 
        115                 120                 125             


Leu Met His Trp His Ile Asp Ala Asn Asn Asn Val Thr Ser His Asp 
    130                 135                 140                 


Gly Gly Asp Gly Ala Ala Thr Asp Ala Asp Glu Asp Ile Ala Leu Ala 
145                 150                 155                 160 


Leu Ile Phe Ala Asp Lys Leu Trp Gly Ser Ser Gly Ala Ile Asn Tyr 
                165                 170                 175     


Gly Gln Glu Ala Arg Thr Leu Ile Asn Asn Leu Tyr Asn His Cys Val 
            180                 185                 190         


Glu His Gly Ser Tyr Val Leu Lys Pro Gly Asp Arg Trp Gly Gly Ser 
        195                 200                 205             


Ser Val Thr Asn Pro Ser Tyr Phe Ala Pro Ala Trp Tyr Lys Val Tyr 
    210                 215                 220                 


Ala Gln Tyr Thr Gly Asp Thr Arg Trp Asn Gln Val Ala Asp Lys Cys 
225                 230                 235                 240 


Tyr Gln Ile Val Glu Glu Val Lys Lys Tyr Asn Asn Gly Thr Gly Leu 
                245                 250                 255     


Val Pro Asp Trp Cys Thr Ala Ser Gly Thr Pro Ala Ser Gly Gln Ser 
            260                 265                 270         


Tyr Asp Tyr Lys Tyr Asp Ala Thr Arg Tyr Gly Trp Arg Thr Ala Val 
        275                 280                 285             


Asp Tyr Ser Trp Phe Gly Asp Gln Arg Ala Lys Ala Asn Cys Asp Met 
    290                 295                 300                 


Leu Thr Lys Phe Phe Ala Arg Asp Gly Ala Lys Gly Ile Val Asp Gly 
305                 310                 315                 320 


Tyr Thr Ile Gln Gly Ser Lys Ile Ser Asn Asn His Asn Ala Ser Phe 
                325                 330                 335     


Ile Gly Pro Val Ala Ala Ala Ser Met Thr Gly Tyr Asp Leu Asn Phe 
            340                 345                 350         


Ala Lys Glu Leu Tyr Arg Glu Thr Val Ala Val Lys Asp Ser Glu Tyr 
        355                 360                 365             


Tyr Gly Tyr Tyr Gly Asn Ser Leu Arg Leu Leu Thr Leu Leu Tyr Ile 
    370                 375                 380                 


Thr Gly Asn Phe Pro Asn Pro Leu Ser Asp Leu Ser Gly Gln Pro Thr 
385                 390                 395                 400 


Pro Pro Ser Asn Pro Thr Pro Ser Leu Pro Pro Gln Val Val Tyr Gly 
                405                 410                 415     


Asp Val Asn Gly Asp Gly Asn Val Asn Ser Thr Asp Leu Thr Met Leu 
            420                 425                 430         


Lys Arg Tyr Leu Leu Lys Ser Val Thr Asn Ile Asn Arg Glu Ala Ala 
        435                 440                 445             


Asp Val Asn Arg Asp Gly Ala Ile Asn Ser Ser Asp Met Thr Ile Leu 
    450                 455                 460                 


Lys Arg Tyr Leu Ile Lys Ser Ile Pro His Leu Pro Tyr 
465                 470                 475         


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Leu Phe Ser Leu Phe Ser Leu Phe Ser 
1               5                   


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Leu Phe Ser Gly Met Thr Lys Pro Ala 
1               5                   


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Leu Leu Leu Leu Leu Val Leu Leu Ala Ser Leu Leu Val Leu Ala Ala 
1               5                   10                  15      


<210> 37
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Leu Leu Leu Ala Leu Leu Leu Ser Leu Ala Leu Leu Leu Ser Leu Ala 
1               5                   10                  15      


Ala Ser 
        


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Leu Leu Leu Ile Leu Leu Leu Leu Leu Leu Leu Leu Ala Val Gly 
1               5                   10                  15  


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Leu Val Leu Ile Leu Phe Ser Ala Leu 
1               5                   


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Gly Gly Gly Gly Ser 
1               5   


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 42
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(20)
<223> This sequence may encompass 1-4 "Gly Gly Gly Gly Ser"
      repeating units

<400> 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 45
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210> 46
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(12)
<223> This sequence may encompass 1-3 "Glu Ala Ala Lys"
      repeating units

<400> 46
Glu Ala Ala Lys Glu Ala Ala Lys Glu Ala Ala Lys 
1               5                   10          


<210> 47
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Pro Ala Pro Ala Pro 
1               5   


<210> 50
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(34)
<223> This sequence may encompass 5-17 "Glu Ala Pro"
      repeating units

<400> 50
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro 
        


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
1               5                   10                  15      


Val 
    


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Pro Leu Gly Leu Trp Ala 
1               5       


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Arg Val Leu Ala Glu Ala 
1               5       


<210> 54
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Glu Asp Val Val Cys Cys Ser Met Ser Tyr 
1               5                   10  


<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Gly Gly Ile Glu Gly Arg Gly Ser 
1               5               


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
1               5                   10  


<210> 57
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ala Gly Asn Arg Val Arg Arg Ser Val Gly 
1               5                   10  


<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 59
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gly Phe Leu Gly 
1               


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 60
His His His His His His 
1               5       


<210> 61
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Leu Phe Ser Leu Phe Ser 
1               5       


<210> 62
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Leu Phe Ser Gly Met Thr 
1               5       


