                         SEQUENCE LISTING

<110>  T3 Pharmaceuticals AG
 
<120>  Pharmaceutical Combinations for Treating Cancer

<130>  P6182PC00

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human RIG1 CARD domains1-245

<400>  1

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile Arg Lys 
145                 150                 155                 160 


Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp Phe Arg 
                165                 170                 175     


Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu Gln Glu 
        195                 200                 205             


Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala Gly Tyr 
    210                 215                 220                 


Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro Glu Phe 
                245                 250                 255     


Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser Thr Lys 
        275                 280                 285             


Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu Lys Glu 
305                 310                 315                 320 


Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile Lys Asp 
                325                 330                 335     


Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp Ile Gln 
            340                 345                 350         


Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu Asn Ser 
        355                 360                 365             


Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro Phe Lys 
    370                 375                 380                 


Pro Arg Asn 
385         


<210>  2
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human RIG1 CARD domains1-228

<400>  2

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile Arg Lys 
145                 150                 155                 160 


Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp Phe Arg 
                165                 170                 175     


Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu Gln Glu 
        195                 200                 205             


Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala Gly Tyr 
    210                 215                 220                 


Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro Glu Phe 
                245                 250                 255     


Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser Thr Lys 
        275                 280                 285             


Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu Lys Glu 
305                 310                 315                 320 


Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile Lys Asp 
                325                 330                 335     


Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp Ile Gln 
            340                 345                 350         


Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu Asn Ser 
        355                 360                 365             


Cys Pro 
    370 


<210>  3
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 -  human RIG1 CARD domains1-217

<400>  3

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile Arg Lys 
145                 150                 155                 160 


Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp Phe Arg 
                165                 170                 175     


Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu Gln Glu 
        195                 200                 205             


Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala Gly Tyr 
    210                 215                 220                 


Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro Glu Phe 
                245                 250                 255     


Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser Thr Lys 
        275                 280                 285             


Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu Lys Glu 
305                 310                 315                 320 


Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile Lys Asp 
                325                 330                 335     


Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp Ile Gln 
            340                 345                 350         


Ile Phe Tyr Gln Glu Asp Pro 
        355                 


<210>  4
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 -  murine RIG1 CARD domains1-246

<400>  4

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Ala Glu Gln Arg Gln Asn Leu Gln Ala Phe Arg Asp Tyr Ile Lys Lys 
145                 150                 155                 160 


Ile Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ser Ser Trp Leu Glu 
                165                 170                 175     


Asp Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Ser Leu Phe Leu Gln Tyr Leu Leu Lys Leu Gln Ser 
        195                 200                 205             


Glu Gly Trp Phe Gln Ala Phe Leu Asp Ala Leu Tyr His Ala Gly Tyr 
    210                 215                 220                 


Cys Gly Leu Cys Glu Ala Ile Glu Ser Trp Asp Phe Gln Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu His Arg Leu Leu Leu Arg Arg Leu Glu Pro Glu Phe 
                245                 250                 255     


Lys Ala Thr Val Asp Pro Asn Asp Ile Leu Ser Glu Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Arg Gln Ile Arg Asp Thr Lys 
        275                 280                 285             


Gly Arg Met Ala Gly Ala Glu Lys Met Ala Glu Cys Leu Ile Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Val Leu Gln Leu Ala Leu Glu Lys Asp 
305                 310                 315                 320 


Asn Ser Lys Phe Ser Glu Leu Trp Ile Val Asp Lys Gly Phe Lys Arg 
                325                 330                 335     


Ala Glu Ser Lys Ala Asp Glu Asp Asp Gly Ala Glu Ala Ser Ser Ile 
            340                 345                 350         


Gln Ile Phe Ile Gln Glu Glu Pro Glu Cys Gln Asn Leu Ser Gln Asn 
        355                 360                 365             


Pro Gly Pro Pro Ser Glu Ala Ser Ser Asn Asn Leu His Ser Pro Leu 
    370                 375                 380                 


Lys Pro Arg Asn 
385             


<210>  5
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine RIG1 CARD domains1-229

<400>  5

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Ala Glu Gln Arg Gln Asn Leu Gln Ala Phe Arg Asp Tyr Ile Lys Lys 
145                 150                 155                 160 


Ile Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ser Ser Trp Leu Glu 
                165                 170                 175     


Asp Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Ser Leu Phe Leu Gln Tyr Leu Leu Lys Leu Gln Ser 
        195                 200                 205             


Glu Gly Trp Phe Gln Ala Phe Leu Asp Ala Leu Tyr His Ala Gly Tyr 
    210                 215                 220                 


Cys Gly Leu Cys Glu Ala Ile Glu Ser Trp Asp Phe Gln Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu His Arg Leu Leu Leu Arg Arg Leu Glu Pro Glu Phe 
                245                 250                 255     


Lys Ala Thr Val Asp Pro Asn Asp Ile Leu Ser Glu Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Arg Gln Ile Arg Asp Thr Lys 
        275                 280                 285             


Gly Arg Met Ala Gly Ala Glu Lys Met Ala Glu Cys Leu Ile Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Val Leu Gln Leu Ala Leu Glu Lys Asp 
305                 310                 315                 320 


Asn Ser Lys Phe Ser Glu Leu Trp Ile Val Asp Lys Gly Phe Lys Arg 
                325                 330                 335     


Ala Glu Ser Lys Ala Asp Glu Asp Asp Gly Ala Glu Ala Ser Ser Ile 
            340                 345                 350         


Gln Ile Phe Ile Gln Glu Glu Pro Glu Cys Gln Asn Leu Ser Gln Asn 
        355                 360                 365             


Pro Gly Pro 
    370     


<210>  6
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine RIG1 CARD domains1-218

<400>  6

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Ala Glu Gln Arg Gln Asn Leu Gln Ala Phe Arg Asp Tyr Ile Lys Lys 
145                 150                 155                 160 


Ile Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ser Ser Trp Leu Glu 
                165                 170                 175     


Asp Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys Gly Pro 
            180                 185                 190         


Met Glu Ala Ala Ser Leu Phe Leu Gln Tyr Leu Leu Lys Leu Gln Ser 
        195                 200                 205             


Glu Gly Trp Phe Gln Ala Phe Leu Asp Ala Leu Tyr His Ala Gly Tyr 
    210                 215                 220                 


Cys Gly Leu Cys Glu Ala Ile Glu Ser Trp Asp Phe Gln Lys Ile Glu 
225                 230                 235                 240 


Lys Leu Glu Glu His Arg Leu Leu Leu Arg Arg Leu Glu Pro Glu Phe 
                245                 250                 255     


Lys Ala Thr Val Asp Pro Asn Asp Ile Leu Ser Glu Leu Ser Glu Cys 
            260                 265                 270         


Leu Ile Asn Gln Glu Cys Glu Glu Ile Arg Gln Ile Arg Asp Thr Lys 
        275                 280                 285             


Gly Arg Met Ala Gly Ala Glu Lys Met Ala Glu Cys Leu Ile Arg Ser 
    290                 295                 300                 


Asp Lys Glu Asn Trp Pro Lys Val Leu Gln Leu Ala Leu Glu Lys Asp 
305                 310                 315                 320 


Asn Ser Lys Phe Ser Glu Leu Trp Ile Val Asp Lys Gly Phe Lys Arg 
                325                 330                 335     


Ala Glu Ser Lys Ala Asp Glu Asp Asp Gly Ala Glu Ala Ser Ser Ile 
            340                 345                 350         


Gln Ile Phe Ile Gln Glu Glu Pro 
        355                 360 


<210>  7
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human MAVS CARD domain1-100

<400>  7

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Pro 
    130                 135                 140                 


Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn 
145                 150                 155                 160 


Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu 
                165                 170                 175     


Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly 
            180                 185                 190         


Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro 
        195                 200                 205             


Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val 
    210                 215                 220                 


Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Glu Ser Tyr Gln Pro Arg 
225                 230                 235                 240 


Thr Ser 
        


<210>  8
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine MAVS CARD domain1-101

<400>  8

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Arg Asp Asn His Ser Lys 
145                 150                 155                 160 


Phe Cys Cys Val Asp Val Leu Glu Ile Leu Pro Tyr Leu Ser Cys Leu 
                165                 170                 175     


Thr Ala Ser Asp Gln Asp Arg Leu Arg Ala Ser Tyr Arg Gln Ile Gly 
            180                 185                 190         


Asn Arg Asp Thr Leu Trp Gly Leu Phe Asn Asn Leu Gln Arg Arg Pro 
        195                 200                 205             


Gly Trp Val Glu Val Phe Ile Arg Ala Leu Gln Ile Cys Glu Leu Pro 
    210                 215                 220                 


Gly Leu Ala Asp Gln Val Thr Arg Val Tyr Gln Ser Tyr Leu Pro Pro 
225                 230                 235                 240 


Gly Thr Ser 
            


<210>  9
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - N. vectensis cGAS

<400>  9

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ala 
    130                 135                 140                 


Thr Leu Glu Arg Leu Leu Asp Leu Leu Arg Glu Tyr His Leu Asp Asp 
145                 150                 155                 160 


Val Leu Phe His Asn Ser Thr Pro Glu Leu Gly Ile Gln His Arg Ser 
                165                 170                 175     


Arg Pro Lys Gln Lys Arg Ile Ile Arg Gly Lys Lys Gln Gln Lys Ser 
            180                 185                 190         


Lys Lys Leu Lys Arg Asn Glu Gln Gln Gln Pro Phe Pro Lys Gly Asp 
        195                 200                 205             


Leu Glu Thr Leu Arg Arg Phe Ser Val Thr Asp Val Lys Ile Ser Lys 
    210                 215                 220                 


Gln Ser Thr Lys Trp Ala Lys Lys Met Ala Asp Lys His Leu Glu Ile 
225                 230                 235                 240 


Ile Arg Lys His Cys Lys Thr Asn Ser Ile Lys Leu Phe Asn His Phe 
                245                 250                 255     


Glu Tyr Thr Gly Ser Phe Tyr Glu His Leu Lys Thr Ile Asp Ala Asp 
            260                 265                 270         


Glu Leu Asp Ile Met Val Ala Leu Ser Ile Lys Met Asp Glu Leu Glu 
        275                 280                 285             


Val Glu Gln Val Thr Pro Gly Tyr Ala Gly Leu Lys Leu Arg Asp Thr 
    290                 295                 300                 


Pro Ser Asn Arg Asn Lys Tyr Asn Asp Leu Thr Ile Ala Asp Asn Tyr 
305                 310                 315                 320 


Gly Arg Tyr Leu Ser Pro Glu Lys Val Ser Arg Trp Phe Phe Ser Leu 
                325                 330                 335     


Val Gln Lys Ala Val Asn Thr Tyr Lys Asp Glu Ile Pro Gln Thr Glu 
            340                 345                 350         


Val Lys Leu Thr Asp Asn Gly Pro Ala Thr Thr Leu Val Ile Thr Tyr 
        355                 360                 365             


Arg Glu Gly Asp Lys Pro Gln Glu Lys Asn Arg Arg Leu Ser Ile Asp 
    370                 375                 380                 


Leu Val Pro Ala Leu Leu Phe Lys Asp Lys Thr Lys Pro Ala Gly Asp 
385                 390                 395                 400 


Asp Leu Arg Ala Trp His Tyr Val Ala Lys Thr Ile Pro Lys Gly Ala 
                405                 410                 415     


Arg Leu Lys Glu Pro Leu Pro Phe Arg Ser Glu Leu Leu Trp Arg Gln 
            420                 425                 430         


Ser Phe Ser Leu Lys Glu Lys His Leu Met Asp Lys Leu Asp Lys Asp 
        435                 440                 445             


Asp Asn Gly Cys Arg Arg Glu Met Val Arg Ile Val Lys Thr Ile Val 
    450                 455                 460                 


Lys Lys Asp Pro Thr Leu Ala Gln Leu Ser Ser Tyr His Ile Lys Thr 
465                 470                 475                 480 


Ala Phe Leu Gln Tyr Asn Phe Ser Asp Val Lys Leu Asp Trp Glu Gly 
                485                 490                 495     


Lys Lys Leu Ala Glu Arg Phe Leu His Phe Leu Glu Phe Leu Arg Asp 
            500                 505                 510         


Arg Val Lys Asp Lys Thr Leu Asn Asn Tyr Phe Ile Thr Asp Leu Asn 
        515                 520                 525             


Leu Leu Asp Asp Leu Asn Asp Ser Asn Ile Asp Asn Ile Ala Asn Arg 
    530                 535                 540                 


Leu Asp Lys Ile Ile Gln Asn Glu Thr Glu Arg Ala Lys Ile Phe Thr 
545                 550                 555                 560 


Thr Gln Arg Gln 
                


<210>  10
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human cGAS161-522

<400>  10

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Gly Ala 
    130                 135                 140                 


Ser Lys Leu Arg Ala Val Leu Glu Lys Leu Lys Leu Ser Arg Asp Asp 
145                 150                 155                 160 


Ile Ser Thr Ala Ala Gly Met Val Lys Gly Val Val Asp His Leu Leu 
                165                 170                 175     


Leu Arg Leu Lys Cys Asp Ser Ala Phe Arg Gly Val Gly Leu Leu Asn 
            180                 185                 190         


Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn Glu Phe 
        195                 200                 205             


Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Gln Leu Glu Glu Tyr 
    210                 215                 220                 


Ser Asn Thr Arg Ala Tyr Tyr Phe Val Lys Phe Lys Arg Asn Pro Lys 
225                 230                 235                 240 


Glu Asn Pro Leu Ser Gln Phe Leu Glu Gly Glu Ile Leu Ser Ala Ser 
                245                 250                 255     


Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Ile Asn Asp 
            260                 265                 270         


Ile Lys Asp Thr Asp Val Ile Met Lys Arg Lys Arg Gly Gly Ser Pro 
        275                 280                 285             


Ala Val Thr Leu Leu Ile Ser Glu Lys Ile Ser Val Asp Ile Thr Leu 
    290                 295                 300                 


Ala Leu Glu Ser Lys Ser Ser Trp Pro Ala Ser Thr Gln Glu Gly Leu 
305                 310                 315                 320 


Arg Ile Gln Asn Trp Leu Ser Ala Lys Val Arg Lys Gln Leu Arg Leu 
                325                 330                 335     


Lys Pro Phe Tyr Leu Val Pro Lys His Ala Lys Glu Gly Asn Gly Phe 
            340                 345                 350         


Gln Glu Glu Thr Trp Arg Leu Ser Phe Ser His Ile Glu Lys Glu Ile 
        355                 360                 365             


Leu Asn Asn His Gly Lys Ser Lys Thr Cys Cys Glu Asn Lys Glu Glu 
    370                 375                 380                 


Lys Cys Cys Arg Lys Asp Cys Leu Lys Leu Met Lys Tyr Leu Leu Glu 
385                 390                 395                 400 


Gln Leu Lys Glu Arg Phe Lys Asp Lys Lys His Leu Asp Lys Phe Ser 
                405                 410                 415     


Ser Tyr His Val Lys Thr Ala Phe Phe His Val Cys Thr Gln Asn Pro 
            420                 425                 430         


Gln Asp Ser Gln Trp Asp Arg Lys Asp Leu Gly Leu Cys Phe Asp Asn 
        435                 440                 445             


Cys Val Thr Tyr Phe Leu Gln Cys Leu Arg Thr Glu Lys Leu Glu Asn 
    450                 455                 460                 


Tyr Phe Ile Pro Glu Phe Asn Leu Phe Ser Ser Asn Leu Ile Asp Lys 
465                 470                 475                 480 


Arg Ser Lys Glu Phe Leu Thr Lys Gln Ile Glu Tyr Glu Arg Asn Asn 
                485                 490                 495     


Glu Phe Pro Val Phe Asp Glu Phe 
            500                 


<210>  11
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine cGAS146-507

<400>  11

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Pro 
    130                 135                 140                 


Asp Lys Leu Lys Lys Val Leu Asp Lys Leu Arg Leu Lys Arg Lys Asp 
145                 150                 155                 160 


Ile Ser Glu Ala Ala Glu Thr Val Asn Lys Val Val Glu Arg Leu Leu 
                165                 170                 175     


Arg Arg Met Gln Lys Arg Glu Ser Glu Phe Lys Gly Val Glu Gln Leu 
            180                 185                 190         


Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn Glu 
        195                 200                 205             


Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Glu Leu Gln Glu 
    210                 215                 220                 


Tyr Tyr Glu Thr Gly Ala Phe Tyr Leu Val Lys Phe Lys Arg Ile Pro 
225                 230                 235                 240 


Arg Gly Asn Pro Leu Ser His Phe Leu Glu Gly Glu Val Leu Ser Ala 
                245                 250                 255     


Thr Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Val Lys 
            260                 265                 270         


Glu Ile Lys Asp Ile Asp Val Ser Val Glu Lys Glu Lys Pro Gly Ser 
        275                 280                 285             


Pro Ala Val Thr Leu Leu Ile Arg Asn Pro Glu Glu Ile Ser Val Asp 
    290                 295                 300                 


Ile Ile Leu Ala Leu Glu Ser Lys Gly Ser Trp Pro Ile Ser Thr Lys 
305                 310                 315                 320 


Glu Gly Leu Pro Ile Gln Gly Trp Leu Gly Thr Lys Val Arg Thr Asn 
                325                 330                 335     


Leu Arg Arg Glu Pro Phe Tyr Leu Val Pro Lys Asn Ala Lys Asp Gly 
            340                 345                 350         


Asn Ser Phe Gln Gly Glu Thr Trp Arg Leu Ser Phe Ser His Thr Glu 
        355                 360                 365             


Lys Tyr Ile Leu Asn Asn His Gly Ile Glu Lys Thr Cys Cys Glu Ser 
    370                 375                 380                 


Ser Gly Ala Lys Cys Cys Arg Lys Glu Cys Leu Lys Leu Met Lys Tyr 
385                 390                 395                 400 


Leu Leu Glu Gln Leu Lys Lys Glu Phe Gln Glu Leu Asp Ala Phe Cys 
                405                 410                 415     


Ser Tyr His Val Lys Thr Ala Ile Phe His Met Trp Thr Gln Asp Pro 
            420                 425                 430         


Gln Asp Ser Gln Trp Asp Pro Arg Asn Leu Ser Ser Cys Phe Asp Lys 
        435                 440                 445             


Leu Leu Ala Phe Phe Leu Glu Cys Leu Arg Thr Glu Lys Leu Asp His 
    450                 455                 460                 


Tyr Phe Ile Pro Lys Phe Asn Leu Phe Ser Gln Glu Leu Ile Asp Arg 
465                 470                 475                 480 


Lys Ser Lys Glu Phe Leu Ser Lys Lys Ile Glu Tyr Glu Arg Asn Asn 
                485                 490                 495     


Gly Phe Pro Ile Phe Asp Lys Leu 
            500                 


<210>  12
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - N. vectensis cGAS60-422

<400>  12

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Gln Pro 
    130                 135                 140                 


Phe Pro Lys Gly Asp Leu Glu Thr Leu Arg Arg Phe Ser Val Thr Asp 
145                 150                 155                 160 


Val Lys Ile Ser Lys Gln Ser Thr Lys Trp Ala Lys Lys Met Ala Asp 
                165                 170                 175     


Lys His Leu Glu Ile Ile Arg Lys His Cys Lys Thr Asn Ser Ile Lys 
            180                 185                 190         


Leu Phe Asn His Phe Glu Tyr Thr Gly Ser Phe Tyr Glu His Leu Lys 
        195                 200                 205             


Thr Ile Asp Ala Asp Glu Leu Asp Ile Met Val Ala Leu Ser Ile Lys 
    210                 215                 220                 


Met Asp Glu Leu Glu Val Glu Gln Val Thr Pro Gly Tyr Ala Gly Leu 
225                 230                 235                 240 


Lys Leu Arg Asp Thr Pro Ser Asn Arg Asn Lys Tyr Asn Asp Leu Thr 
                245                 250                 255     


Ile Ala Asp Asn Tyr Gly Arg Tyr Leu Ser Pro Glu Lys Val Ser Arg 
            260                 265                 270         


Trp Phe Phe Ser Leu Val Gln Lys Ala Val Asn Thr Tyr Lys Asp Glu 
        275                 280                 285             


Ile Pro Gln Thr Glu Val Lys Leu Thr Asp Asn Gly Pro Ala Thr Thr 
    290                 295                 300                 


Leu Val Ile Thr Tyr Arg Glu Gly Asp Lys Pro Gln Glu Lys Asn Arg 
305                 310                 315                 320 


Arg Leu Ser Ile Asp Leu Val Pro Ala Leu Leu Phe Lys Asp Lys Thr 
                325                 330                 335     


Lys Pro Ala Gly Asp Asp Leu Arg Ala Trp His Tyr Val Ala Lys Thr 
            340                 345                 350         


Ile Pro Lys Gly Ala Arg Leu Lys Glu Pro Leu Pro Phe Arg Ser Glu 
        355                 360                 365             


Leu Leu Trp Arg Gln Ser Phe Ser Leu Lys Glu Lys His Leu Met Asp 
    370                 375                 380                 


Lys Leu Asp Lys Asp Asp Asn Gly Cys Arg Arg Glu Met Val Arg Ile 
385                 390                 395                 400 


Val Lys Thr Ile Val Lys Lys Asp Pro Thr Leu Ala Gln Leu Ser Ser 
                405                 410                 415     


Tyr His Ile Lys Thr Ala Phe Leu Gln Tyr Asn Phe Ser Asp Val Lys 
            420                 425                 430         


Leu Asp Trp Glu Gly Lys Lys Leu Ala Glu Arg Phe Leu His Phe Leu 
        435                 440                 445             


Glu Phe Leu Arg Asp Arg Val Lys Asp Lys Thr Leu Asn Asn Tyr Phe 
    450                 455                 460                 


Ile Thr Asp Leu Asn Leu Leu Asp Asp Leu Asn Asp Ser Asn Ile Asp 
465                 470                 475                 480 


Asn Ile Ala Asn Arg Leu Asp Lys Ile Ile Gln Asn Glu Thr Glu Arg 
                485                 490                 495     


Ala Lys Ile Phe Thr Thr Gln Arg Gln 
            500                 505 


<210>  13
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 -  murine MDA51-294

<400>  13

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Ile Val Cys Ser Ala Glu Asp Ser Phe Arg Asn Leu Ile Leu Phe Phe 
145                 150                 155                 160 


Arg Pro Arg Leu Lys Met Tyr Ile Gln Val Glu Pro Val Leu Asp His 
                165                 170                 175     


Leu Ile Phe Leu Ser Ala Glu Thr Lys Glu Gln Ile Leu Lys Lys Ile 
            180                 185                 190         


Asn Thr Cys Gly Asn Thr Ser Ala Ala Glu Leu Leu Leu Ser Thr Leu 
        195                 200                 205             


Glu Gln Gly Gln Trp Pro Leu Gly Trp Thr Gln Met Phe Val Glu Ala 
    210                 215                 220                 


Leu Glu His Ser Gly Asn Pro Leu Ala Ala Arg Tyr Val Lys Pro Thr 
225                 230                 235                 240 


Leu Thr Asp Leu Pro Ser Pro Ser Ser Glu Thr Ala His Asp Glu Cys 
                245                 250                 255     


Leu His Leu Leu Thr Leu Leu Gln Pro Thr Leu Val Asp Lys Leu Leu 
            260                 265                 270         


Ile Asn Asp Val Leu Asp Thr Cys Phe Glu Lys Gly Leu Leu Thr Val 
        275                 280                 285             


Glu Asp Arg Asn Arg Ile Ser Ala Ala Gly Asn Ser Gly Asn Glu Ser 
    290                 295                 300                 


Gly Val Arg Glu Leu Leu Arg Arg Ile Val Gln Lys Glu Asn Trp Phe 
305                 310                 315                 320 


Ser Thr Phe Leu Asp Val Leu Arg Gln Thr Gly Asn Asp Ala Leu Phe 
                325                 330                 335     


Gln Glu Leu Thr Gly Gly Gly Cys Pro Glu Asp Asn Thr Asp Leu Ala 
            340                 345                 350         


Asn Ser Ser His Arg Asp Gly Pro Ala Ala Asn Glu Cys Leu Leu Pro 
        355                 360                 365             


Ala Val Asp Glu Ser Ser Leu Glu Thr Glu Ala Trp Asn Val Asp Asp 
    370                 375                 380                 


Ile Leu Pro Glu Ala Ser Cys Thr Asp Ser Ser Val Thr Thr Glu Ser 
385                 390                 395                 400 


Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Phe Asp Glu Ser Leu 
                405                 410                 415     


Gly His Asn Ser Asn Met Gly Arg Asp Ser Gly Thr Met Gly Ser Asp 
            420                 425                 430         


Ser Asp Glu Ser 
        435     


<210>  14
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine MDA51-231

<400>  14

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Ile Val Cys Ser Ala Glu Asp Ser Phe Arg Asn Leu Ile Leu Phe Phe 
145                 150                 155                 160 


Arg Pro Arg Leu Lys Met Tyr Ile Gln Val Glu Pro Val Leu Asp His 
                165                 170                 175     


Leu Ile Phe Leu Ser Ala Glu Thr Lys Glu Gln Ile Leu Lys Lys Ile 
            180                 185                 190         


Asn Thr Cys Gly Asn Thr Ser Ala Ala Glu Leu Leu Leu Ser Thr Leu 
        195                 200                 205             


Glu Gln Gly Gln Trp Pro Leu Gly Trp Thr Gln Met Phe Val Glu Ala 
    210                 215                 220                 


Leu Glu His Ser Gly Asn Pro Leu Ala Ala Arg Tyr Val Lys Pro Thr 
225                 230                 235                 240 


Leu Thr Asp Leu Pro Ser Pro Ser Ser Glu Thr Ala His Asp Glu Cys 
                245                 250                 255     


Leu His Leu Leu Thr Leu Leu Gln Pro Thr Leu Val Asp Lys Leu Leu 
            260                 265                 270         


Ile Asn Asp Val Leu Asp Thr Cys Phe Glu Lys Gly Leu Leu Thr Val 
        275                 280                 285             


Glu Asp Arg Asn Arg Ile Ser Ala Ala Gly Asn Ser Gly Asn Glu Ser 
    290                 295                 300                 


Gly Val Arg Glu Leu Leu Arg Arg Ile Val Gln Lys Glu Asn Trp Phe 
305                 310                 315                 320 


Ser Thr Phe Leu Asp Val Leu Arg Gln Thr Gly Asn Asp Ala Leu Phe 
                325                 330                 335     


Gln Glu Leu Thr Gly Gly Gly Cys Pro Glu Asp Asn Thr Asp Leu Ala 
            340                 345                 350         


Asn Ser Ser His Arg Asp Gly Pro Ala Ala Asn Glu Cys Leu Leu Pro 
        355                 360                 365             


Ala Val Asp Glu Ser 
    370             


<210>  15
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human MDA51-294

<400>  15

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser Cys Phe 
145                 150                 155                 160 


Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu Asp Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg Thr Val 
            180                 185                 190         


Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val Glu Ala 
    210                 215                 220                 


Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn Pro Glu 
225                 230                 235                 240 


Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp Glu Tyr 
                245                 250                 255     


Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys Leu Leu 
            260                 265                 270         


Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu Thr Ile 
        275                 280                 285             


Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn Glu Ser 
    290                 295                 300                 


Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn Trp Phe 
305                 310                 315                 320 


Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu Leu Val 
                325                 330                 335     


Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu Ile Glu 
            340                 345                 350         


Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu Leu Ser 
        355                 360                 365             


Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met Glu Asn 
    370                 375                 380                 


Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser Glu Ser 
385                 390                 395                 400 


Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu Ser Leu 
                405                 410                 415     


Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly Ser Asp 
            420                 425                 430         


Ser Asp Glu Glu 
        435     


<210>  16
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human MDA51-231

<400>  16

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser Cys Phe 
145                 150                 155                 160 


Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu Asp Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg Thr Val 
            180                 185                 190         


Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser Thr Leu 
        195                 200                 205             


Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val Glu Ala 
    210                 215                 220                 


Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn Pro Glu 
225                 230                 235                 240 


Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp Glu Tyr 
                245                 250                 255     


Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys Leu Leu 
            260                 265                 270         


Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu Thr Ile 
        275                 280                 285             


Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn Glu Ser 
    290                 295                 300                 


Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn Trp Phe 
305                 310                 315                 320 


Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu Leu Val 
                325                 330                 335     


Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu Ile Glu 
            340                 345                 350         


Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu Leu Ser 
        355                 360                 365             


Thr Thr Val Gln Pro 
    370             


<210>  17
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp 
1               5                   10                  15      


Ser Met Asp Arg 
            20  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp Arg Ser 
1               5                   10                  15  


<210>  19
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp 
1               5                   10                  15      


Glu Met Asp His 
            20  


<210>  20
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  20

Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu Met Asp His 
1               5                   10                  


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Lys Leu Ser Glu Cys Leu Lys Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  15      


Asn 
    


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Leu Ser Glu Cys Leu Lys Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  


<210>  23
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  23

Lys Lys Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  15      


Asn 
    


<210>  24
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  24

Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  


<210>  25
<211>  138
<212>  PRT
<213>  Yersinia enterocolitica

<400>  25

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr 
    130                 135             


<210>  26
<211>  81
<212>  PRT
<213>  Salmonella enterica

<400>  26

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys 
    


<210>  27
<211>  105
<212>  PRT
<213>  Salmonella enterica

<400>  27

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala 
            100                 105 


<210>  28
<211>  210
<212>  PRT
<213>  Salmonella enterica

<400>  28

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr 
    210 


<210>  29
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBR322 ori

<400>  29
tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc       60

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc      120

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt      180

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc      240

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact      300

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac      360

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag      420

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg      480

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg      540

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga      600

gcctatggaa aaacgccagc aacgcggcc                                        629


<210>  30
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ColE1 ori

<400>  30
tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc       60

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc      120

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt      180

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc      240

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact      300

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac      360

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag      420

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg      480

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg      540

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga      600

gcctatggaa aaacgccagc aacgcggcc                                        629


<210>  31
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rop

<400>  31
atgaacagaa atccccctta cacggaggca tcagtgacca aacaggaaaa aaccgccctt       60

aacatggccc gctttatcag aagccagaca ttaacgcttc tggagaaact caacgagctg      120

gacgcggatg aacaggcaga catctgtgaa tcgcttcacg accacgctga tgagctttac      180

cgcagctgcc tcgcgcgttt cggtgatgac ggtgaaaacc tctga                      225


<210>  32
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer-T3T_887

<400>  32
cacatgtggt cgacgaatag acagcgaaag ttgttgaaat aattg                       45


<210>  33
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer-T3T_955

<400>  33
cactaccccc ttgtttttat ccatattaat tgcgcggttt aaacggg                     47


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - T3T_956

<400>  34
tatggataaa aacaaggggg tagtg                                             25


<210>  35
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer - T3T_888

<400>  35
catgcgaatg ggcccgtttt cagtataaaa agcacggtat atac                        44


<210>  36
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Multiple cloning site directly following the yopE1-138 fragment 
       on pBad_Si2 plasmid

<400>  36
gttcgccacg ctcgagtcta gattcgaaaa gcttgggccc gaacaaaaac tcatctcaga       60

agaggatctg aatagcgccg tcgaccatca tcatcatcat cattgagttt aaacggtctc      120

cagcttggct gttttggc                                                    138


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by Enterokinase (light chain) / 
       Enteropeptidase

<400>  37

Asp Asp Asp Asp Lys 
1               5   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by PreScission Protease/human 
       Rhinovirusprotease (HRV 3C)

<400>  38

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by TEV protease (tobacco etch virus)

<400>  39

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified amino acid motifs based on the Glu-X-X-Tyr-X-Gln/Gly or 
       Ser (where X is any amino acid) recognized by TEV protease 
       (tobacco etch virus)


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be serine or glycine

<400>  40

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by TVMV protease

<400>  41

Glu Thr Val Arg Phe Gln Ser 
1               5           


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by FactorXa protease


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be glutamic acid or aspartic acid

<400>  42

Ile Xaa Gly Arg 
1               


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid motif recognized by Thrombin

<400>  43

Leu Val Pro Arg Gly Ser 
1               5       


<210>  44
<211>  8
<212>  PRT
<213>  Simian virus 40

<400>  44

Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


