                               SEQUENCE LISTING

<110> BEAM THERAPEUTICS INC.
 
<120> NOVEL CRISPR ENZYMES, METHODS, SYSTEMS AND USES THEREOF

<130> BEM-004WO1

<140> PCT/US2022/021523
<141> 2022-03-23

<150> 63/164,798
<151> 2021-03-23

<160> 182   

<170> PatentIn version 3.5

<210> 1
<211> 1345
<212> PRT
<213> Streptococcus constellatus

<400> 1
Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asp Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Arg Ile Glu  Lys Asp Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210> 2
<211> 1399
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Pro Lys Lys Lys Arg Lys Val Gly Gly Lys Pro Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp Asp 
            20                  25                  30          


Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp Lys 
        35                  40                  45              


Gln Ser Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu Ile Phe Thr Gly 
                85                  90                  95      


Glu Met Asn Lys Val Asp Glu Asn Phe Phe Gln Arg Leu Asp Asp Ser 
            100                 105                 110         


Phe Leu Val Asp Glu Asp Lys Arg Gly Glu His His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Ala Ala Glu Val Lys Tyr His Asp Asp Phe Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Arg His Leu Ala Asp Thr Ser Lys Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Tyr Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp Val Gln Ala Leu 
            180                 185                 190         


Phe Lys Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile Glu Glu Ser His 
        195                 200                 205             


Leu Ser Glu Ile Thr Val Asp Ala Leu Ser Ile Leu Thr Glu Lys Val 
    210                 215                 220                 


Ser Lys Ser Ser Arg Leu Glu Asn Leu Ile Ala His Tyr Pro Thr Glu 
225                 230                 235                 240 


Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Asp Leu 
                245                 250                 255     


His Pro Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu Gly Phe Leu Gly 
        275                 280                 285             


Glu Val Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser Ala Lys Asn Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu Thr Val Asp Asp Asn Ser 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Glu Glu His 
                325                 330                 335     


Gln Lys Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys Val Asn Ala Pro 
            340                 345                 350         


Asp Gln Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys Lys Gly Tyr Ala 
        355                 360                 365             


Ser Tyr Ile Glu Ser Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu 
    370                 375                 380                 


Lys Gly Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp Phe Leu Asp Lys 
385                 390                 395                 400 


Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp Glu Lys 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys Ser Ala 
                485                 490                 495     


Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Ala Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly Glu Ala 
    530                 535                 540                 


Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His Val Phe 
545                 550                 555                 560 


Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr Leu Asn 
                565                 570                 575     


Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu Asp Lys 
            580                 585                 590         


Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr His Asp Leu Arg 
        595                 600                 605             


Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala Asn Glu Lys Thr 
    610                 615                 620                 


Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys Ala Gln 
                645                 650                 655     


Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe Met Gln 
    690                 695                 700                 


Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Arg Ala 
705                 710                 715                 720 


Gln Ile Ile Asp Asp Val Asp Asp Ile Ala Asn Val Val His Asp Leu 
                725                 730                 735     


Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile 
            740                 745                 750         


Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn Ile Ile 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg Arg Asn 
    770                 775                 780                 


Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn Leu Asp 
785                 790                 795                 800 


Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu 
    850                 855                 860                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu Ser Val 
                885                 890                 895     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Glu 
    930                 935                 940                 


Arg Phe Asn Thr Glu Phe Asp Gly Asn Lys Arg Arg Ile Arg Asn Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Asn Ala Leu Leu  Leu Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Glu Pro Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Tyr Arg Ser Arg Lys  Ser Ala Thr Glu Lys  Phe Leu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Leu Arg Phe  Phe Lys Lys Glu Asp  Ile Gln Thr 
    1040                 1045                 1050             


Asn Glu  Asp Gly Glu Ile Ala  Trp Asn Lys Glu Lys  His Ile Lys 
    1055                 1060                 1065             


Ile Leu  Arg Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1085                 1090                 1095             


Pro Lys  Gly Glu Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Asn 
    1100                 1105                 1110             


Ser Tyr  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Val 
    1115                 1120                 1125             


Val Ala  Tyr Ser Ile Leu Val  Phe Ala Asp Val Glu  Lys Gly Lys 
    1130                 1135                 1140             


Ser Lys  Lys Leu Arg Lys Val  Gln Asp Met Val Gly  Ile Thr Ile 
    1145                 1150                 1155             


Met Glu  Lys Lys Arg Phe Glu  Lys Asn Pro Val Asp  Phe Leu Glu 
    1160                 1165                 1170             


Gln Arg  Gly Tyr Arg Asn Val  Arg Leu Glu Lys Ile  Ile Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Lys Arg  Arg Arg Leu 
    1190                 1195                 1200             


Leu Ala  Ser Ala Lys Glu Leu  Gln Lys Gly Asn Glu  Leu Val Ile 
    1205                 1210                 1215             


Pro Gln  Arg Phe Thr Thr Leu  Leu Tyr His Ser Tyr  Arg Ile Glu 
    1220                 1225                 1230             


Lys Asp  Tyr Glu Pro Glu His  Arg Glu Tyr Val Glu  Lys His Lys 
    1235                 1240                 1245             


Asp Glu  Phe Lys Glu Leu Leu  Glu Tyr Ile Ser Val  Phe Ser Arg 
    1250                 1255                 1260             


Lys Tyr  Val Leu Ala Asp Asn  Asn Leu Thr Lys Ile  Glu Met Leu 
    1265                 1270                 1275             


Phe Ser  Lys Asn Lys Asp Ala  Glu Val Ser Ser Leu  Ala Lys Ser 
    1280                 1285                 1290             


Phe Ile  Ser Leu Leu Thr Phe  Thr Ala Phe Gly Ala  Pro Ala Ala 
    1295                 1300                 1305             


Phe Asn  Phe Phe Gly Glu Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1310                 1315                 1320             


Val Thr  Glu Cys Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1325                 1330                 1335             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asp 
    1340                 1345                 1350             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1355                 1360                 1365             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1370                 1375                 1380             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1385                 1390                 1395             


Ala 
    


<210> 3
<211> 92
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
guuuuagagc ugugcuguuu aaacaacaca gcaaguuaaa auaaggcuuu guccguacuc       60

aagcuugcaa aagcgugcac cgauucggug cu                                     92


<210> 4
<211> 1326
<212> PRT
<213> Sharpea sp.

<400> 4
Met Ala Lys Asn Lys Asp Ile Arg Tyr Ser Ile Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Ala Val Met Asp Glu His Tyr Glu Leu Leu 
            20                  25                  30          


Lys Lys Gly Asn His His Met Trp Gly Ser Arg Leu Phe Asp Ala Ala 
        35                  40                  45              


Glu Pro Ala Ala Thr Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr 
    50                  55                  60                  


Asn Lys Arg Arg Glu Arg Ile Arg Leu Leu Arg Asp Leu Leu Gly Asp 
65                  70                  75                  80  


Met Val Met Glu Val Asp Pro Thr Phe Phe Ile Arg Leu Leu Asn Val 
                85                  90                  95      


Ser Phe Leu Asp Glu Glu Asp Lys Gln Lys Asn Leu Gly Asn Asp Tyr 
            100                 105                 110         


Lys Asp Asn Tyr Asn Leu Phe Ile Glu Lys Asp Phe Asn Asp Lys Thr 
        115                 120                 125             


Tyr Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Cys 
    130                 135                 140                 


Glu Asn Lys Glu Lys Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His 
145                 150                 155                 160 


His Ile Val Lys Tyr Arg Gly Asn Phe Leu Lys Glu Gly Gln Ser Phe 
                165                 170                 175     


Ala Lys Val Tyr Glu Asp Ile Glu Glu Lys Leu Asp Asn Thr Leu Lys 
            180                 185                 190         


Lys Phe Met Ser Leu Asn Asp Leu Asp Asn Leu Phe Val Asp Asn Asp 
        195                 200                 205             


Ile Asn Ser Met Ile Thr Val Leu Ser Lys Ile Tyr Gln Arg Ser Lys 
    210                 215                 220                 


Lys Ala Asp Asp Leu Leu Lys Ile Met Asn Pro Thr Lys Glu Glu Arg 
225                 230                 235                 240 


Ala Ala Tyr Lys Glu Phe Thr Lys Ala Leu Val Gly Leu Lys Phe Asn 
                245                 250                 255     


Val Ser Lys Met Ile Leu Ala Gln Glu Val Lys Lys Asp Asp Lys Asp 
            260                 265                 270         


Ile Glu Leu Asp Phe Ser Asn Val Asp Tyr Asp Ser Thr Val Asp Gly 
        275                 280                 285             


Leu Gln Ala Glu Leu Gly Glu Tyr Ile Glu Phe Ile Glu Met Leu His 
    290                 295                 300                 


Ser Ile Asn Ser Trp Val Glu Leu Gln Asp Ile Leu Gly Asn Asn Ser 
305                 310                 315                 320 


Thr Ile Ser Ala Ala Met Val Glu Arg Tyr Glu Glu His Lys Asn Asp 
                325                 330                 335     


Leu Arg Val Leu Lys Lys Val Ile Arg Glu Glu Leu Pro Asp Lys Tyr 
            340                 345                 350         


Asn Glu Val Phe Arg Glu Asp Asn Pro Lys Leu His Asn Tyr Leu Gly 
        355                 360                 365             


Tyr Ile Lys Tyr Pro Lys Asn Thr Pro Val Glu Glu Phe Tyr Glu Tyr 
    370                 375                 380                 


Ile Lys Arg Leu Leu Ala Lys Val Asp Thr Gly Glu Ala Arg Glu Ile 
385                 390                 395                 400 


Leu Glu Arg Ile Asp Leu Glu Lys Phe Met Leu Lys Gln Asn Ser Arg 
                405                 410                 415     


Thr Asn Gly Ser Ile Pro Tyr Gln Met Gln Lys Asp Glu Met Ile Gln 
            420                 425                 430         


Ile Ile Asp Asn Gln Ser Val Tyr Tyr Pro Gln Leu Lys Glu Asn Arg 
        435                 440                 445             


Glu Lys Leu Ile Ser Ile Leu Glu Phe Arg Ile Pro Tyr Tyr Phe Gly 
    450                 455                 460                 


Pro Leu Asn Thr His Ser Glu Phe Ala Trp Ile Lys Lys Phe Glu Asp 
465                 470                 475                 480 


Lys Gln Lys Glu Arg Ile Leu Pro Trp Asn Tyr Asp Gln Ile Val Asp 
                485                 490                 495     


Ile Asp Ala Thr Ala Glu Gly Phe Ile Glu Arg Met Gln Asn Thr Gly 
            500                 505                 510         


Thr Tyr Phe Pro Asp Lys Pro Val Met Ala Lys Asn Ser Leu Thr Val 
        515                 520                 525             


Ser Lys Phe Glu Val Leu Asn Glu Leu Asn Lys Ile Arg Ile Asn Gly 
    530                 535                 540                 


Lys Leu Ile Pro Val Glu Thr Lys Lys Glu Leu Leu Ser Asp Leu Phe 
545                 550                 555                 560 


Met Lys Asn Lys Thr Ile Thr Asp Lys Lys Leu Lys Asp Trp Leu Val 
                565                 570                 575     


Thr His Gln Tyr Tyr Asp Thr Asn Glu Glu Leu Lys Ile Glu Gly Tyr 
            580                 585                 590         


Gln Lys Asp Leu Gln Phe Ser Thr Ser Leu Ala Pro Trp Ile Asp Phe 
        595                 600                 605             


Thr Lys Ile Phe Gly Glu Ile Asn Ala Ser Asn Tyr Gln Leu Ile Glu 
    610                 615                 620                 


Lys Ile Ile Tyr Asp Ile Ser Ile Phe Glu Asp Lys Lys Ile Leu Lys 
625                 630                 635                 640 


Arg Arg Leu Lys Lys Val Tyr Gln Leu Asp Asp Leu Leu Val Asp Lys 
                645                 650                 655     


Ile Leu Lys Leu Asn Tyr Thr Gly Trp Ser Arg Leu Ser Glu Lys Leu 
            660                 665                 670         


Leu Thr Gly Ile Lys Ser Lys Asn Ser Lys Glu Thr Ile Leu Ser Ile 
        675                 680                 685             


Leu Glu Asn Ser Asn Met Asn Leu Met Glu Ile Ile Asn Asp Glu Ser 
    690                 695                 700                 


Leu Gly Phe Lys Gln Ile Ile Glu Glu Ser Asn Lys Lys Asp Ile Glu 
705                 710                 715                 720 


Gly Pro Phe Arg Tyr Asp Glu Val Lys Lys Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Arg Gly Ile Trp Gln Ala Leu Leu Val Val Gln Glu Ile Thr 
            740                 745                 750         


Lys Phe Met Lys His Glu Pro Ser His Ile Tyr Ile Glu Phe Ala Arg 
        755                 760                 765             


Glu Glu Gln Glu Lys Val Arg Thr Glu Ser Arg Ile Ala Lys Leu Gln 
    770                 775                 780                 


Lys Ile Tyr Lys Asp Leu Asn Leu Gln Thr Lys Glu Asp Gln Leu Val 
785                 790                 795                 800 


Tyr Glu Ser Leu Lys Lys Glu Asp Ala Lys Lys Lys Ile Asp Thr Asp 
                805                 810                 815     


Ala Leu Tyr Leu Tyr Tyr Leu Gln Met Gly Lys Ser Met Tyr Ser Gly 
            820                 825                 830         


Lys Pro Leu Asp Ile Asp Lys Leu Ser Thr Tyr His Ile Asp His Ile 
        835                 840                 845             


Leu Pro Arg Ser Leu Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu 
    850                 855                 860                 


Val Leu Pro Lys Glu Asn Glu Trp Lys Leu Asp Ser Glu Thr Val Pro 
865                 870                 875                 880 


Phe Glu Ile Arg Asn Lys Met Met Gly Phe Trp Gln Lys Leu His Glu 
                885                 890                 895     


Asn Gly Leu Met Ser Asn Lys Lys Phe Phe Ser Leu Ile Arg Thr Asp 
            900                 905                 910         


Phe Asn Glu Lys Asp Lys Lys Arg Phe Ile Asn Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Ile Lys Asn Val Ala Val Ile Ile Asn Asp His Tyr 
    930                 935                 940                 


Thr Asn Thr Asn Val Val Thr Val Arg Ala Glu Leu Ser His Gln Phe 
945                 950                 955                 960 


Arg Glu Arg Tyr Lys Ile Tyr Lys Asn Arg Asp Leu Asn Asp Leu His 
                965                 970                 975     


His Ala His Asp Ala Tyr Ile Ala Cys Ile Leu Gly Gln Phe Ile His 
            980                 985                 990         


Gln Asn Phe Gly Asn Met Asp Val  Asn Met Ile Tyr Gly  Gln Tyr Lys 
        995                 1000                 1005             


Lys Asn  Tyr Lys Lys Asp Val  Gln Glu His Asn Asn  Tyr Gly Phe 
    1010                 1015                 1020             


Ile Leu  Asn Ser Met Asn His  Ile His Phe Asn Asp  Asp Asn Ser 
    1025                 1030                 1035             


Val Ile  Trp Asp Pro Ser Tyr  Ile Gly Lys Ile Lys  Ser Cys Phe 
    1040                 1045                 1050             


Cys Tyr  Lys Asp Val Tyr Val  Thr Lys Lys Leu Glu  Gln Asn Asp 
    1055                 1060                 1065             


Ala Lys  Leu Phe Asp Leu Thr  Ile Leu Pro Ser Asp  Lys Asn Ser 
    1070                 1075                 1080             


Glu Asn  Gly Val Thr Lys Ala  Lys Ile Pro Val Asn  Lys Tyr Arg 
    1085                 1090                 1095             


Lys Asp  Val Asn Lys Tyr Gly  Gly Phe Ser Gly Asp  Ala Pro Ile 
    1100                 1105                 1110             


Met Leu  Ala Ile Glu Ala Asp  Lys Gly Lys Lys His  Val Arg Gln 
    1115                 1120                 1125             


Val Ile  Ala Phe Pro Leu Arg  Leu Lys Asn Tyr Asn  Asp Glu Glu 
    1130                 1135                 1140             


Arg Ile  Lys Phe Ile Glu Lys  Glu Lys Asn Leu Lys  Asn Val Lys 
    1145                 1150                 1155             


Ile Leu  Thr Glu Val Lys Lys  Asn Gln Leu Ile Leu  Ile Asn His 
    1160                 1165                 1170             


Gln Tyr  Phe Phe Ile Thr Gly  Thr Asn Glu Leu Val  Asn Ala Thr 
    1175                 1180                 1185             


Gln Leu  Lys Leu Ser Ala Lys  Asn Thr Lys Asn Leu  Phe Asn Leu 
    1190                 1195                 1200             


Val Asp  Ala Asn Lys His Asn  Lys Leu Glu Ser Ile  Asp Asp Ala 
    1205                 1210                 1215             


Asn Phe  Asn Glu Val Ile Gln  Glu Leu Ile Cys Lys  Leu Gln Glu 
    1220                 1225                 1230             


Pro Ile  Tyr Ser Arg Tyr Asn  Ser Ile Gly Lys Glu  Phe Glu Asp 
    1235                 1240                 1245             


Ser Tyr  Glu Lys Ile Asn Ala  Val Thr Lys Gln Asp  Lys Leu Tyr 
    1250                 1255                 1260             


Ile Ile  Glu Tyr Leu Ile Ala  Ile Met Ser Ala Lys  Ala Thr Gln 
    1265                 1270                 1275             


Gly Tyr  Ile Lys Pro Glu Leu  Ala Arg Glu Ile Gly  Thr Asn Gly 
    1280                 1285                 1290             


Lys Asn  Lys Gly Arg Ile Lys  Ser Phe Thr Ile Asp  Leu Asn Lys 
    1295                 1300                 1305             


Thr Thr  Phe Ile Ser Thr Ser  Val Thr Gly Leu Phe  Ser Lys Lys 
    1310                 1315                 1320             


Tyr Lys  Leu 
    1325     


<210> 5
<211> 1380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Pro Lys Lys Lys Arg Lys Val Gly Ala Lys Asn Lys Asp Ile Arg 
1               5                   10                  15      


Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            20                  25                  30          


Met Asp Glu His Tyr Glu Leu Leu Lys Lys Gly Asn His His Met Trp 
        35                  40                  45              


Gly Ser Arg Leu Phe Asp Ala Ala Glu Pro Ala Ala Thr Arg Arg Ala 
    50                  55                  60                  


Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg Glu Arg Ile Arg 
65                  70                  75                  80  


Leu Leu Arg Asp Leu Leu Gly Asp Met Val Met Glu Val Asp Pro Thr 
                85                  90                  95      


Phe Phe Ile Arg Leu Leu Asn Val Ser Phe Leu Asp Glu Glu Asp Lys 
            100                 105                 110         


Gln Lys Asn Leu Gly Asn Asp Tyr Lys Asp Asn Tyr Asn Leu Phe Ile 
        115                 120                 125             


Glu Lys Asp Phe Asn Asp Lys Thr Tyr Tyr Asp Lys Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Glu Leu Cys Glu Asn Lys Glu Lys Ala Asp Pro 
145                 150                 155                 160 


Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr Arg Gly Asn 
                165                 170                 175     


Phe Leu Lys Glu Gly Gln Ser Phe Ala Lys Val Tyr Glu Asp Ile Glu 
            180                 185                 190         


Glu Lys Leu Asp Asn Thr Leu Lys Lys Phe Met Ser Leu Asn Asp Leu 
        195                 200                 205             


Asp Asn Leu Phe Val Asp Asn Asp Ile Asn Ser Met Ile Thr Val Leu 
    210                 215                 220                 


Ser Lys Ile Tyr Gln Arg Ser Lys Lys Ala Asp Asp Leu Leu Lys Ile 
225                 230                 235                 240 


Met Asn Pro Thr Lys Glu Glu Arg Ala Ala Tyr Lys Glu Phe Thr Lys 
                245                 250                 255     


Ala Leu Val Gly Leu Lys Phe Asn Val Ser Lys Met Ile Leu Ala Gln 
            260                 265                 270         


Glu Val Lys Lys Asp Asp Lys Asp Ile Glu Leu Asp Phe Ser Asn Val 
        275                 280                 285             


Asp Tyr Asp Ser Thr Val Asp Gly Leu Gln Ala Glu Leu Gly Glu Tyr 
    290                 295                 300                 


Ile Glu Phe Ile Glu Met Leu His Ser Ile Asn Ser Trp Val Glu Leu 
305                 310                 315                 320 


Gln Asp Ile Leu Gly Asn Asn Ser Thr Ile Ser Ala Ala Met Val Glu 
                325                 330                 335     


Arg Tyr Glu Glu His Lys Asn Asp Leu Arg Val Leu Lys Lys Val Ile 
            340                 345                 350         


Arg Glu Glu Leu Pro Asp Lys Tyr Asn Glu Val Phe Arg Glu Asp Asn 
        355                 360                 365             


Pro Lys Leu His Asn Tyr Leu Gly Tyr Ile Lys Tyr Pro Lys Asn Thr 
    370                 375                 380                 


Pro Val Glu Glu Phe Tyr Glu Tyr Ile Lys Arg Leu Leu Ala Lys Val 
385                 390                 395                 400 


Asp Thr Gly Glu Ala Arg Glu Ile Leu Glu Arg Ile Asp Leu Glu Lys 
                405                 410                 415     


Phe Met Leu Lys Gln Asn Ser Arg Thr Asn Gly Ser Ile Pro Tyr Gln 
            420                 425                 430         


Met Gln Lys Asp Glu Met Ile Gln Ile Ile Asp Asn Gln Ser Val Tyr 
        435                 440                 445             


Tyr Pro Gln Leu Lys Glu Asn Arg Glu Lys Leu Ile Ser Ile Leu Glu 
    450                 455                 460                 


Phe Arg Ile Pro Tyr Tyr Phe Gly Pro Leu Asn Thr His Ser Glu Phe 
465                 470                 475                 480 


Ala Trp Ile Lys Lys Phe Glu Asp Lys Gln Lys Glu Arg Ile Leu Pro 
                485                 490                 495     


Trp Asn Tyr Asp Gln Ile Val Asp Ile Asp Ala Thr Ala Glu Gly Phe 
            500                 505                 510         


Ile Glu Arg Met Gln Asn Thr Gly Thr Tyr Phe Pro Asp Lys Pro Val 
        515                 520                 525             


Met Ala Lys Asn Ser Leu Thr Val Ser Lys Phe Glu Val Leu Asn Glu 
    530                 535                 540                 


Leu Asn Lys Ile Arg Ile Asn Gly Lys Leu Ile Pro Val Glu Thr Lys 
545                 550                 555                 560 


Lys Glu Leu Leu Ser Asp Leu Phe Met Lys Asn Lys Thr Ile Thr Asp 
                565                 570                 575     


Lys Lys Leu Lys Asp Trp Leu Val Thr His Gln Tyr Tyr Asp Thr Asn 
            580                 585                 590         


Glu Glu Leu Lys Ile Glu Gly Tyr Gln Lys Asp Leu Gln Phe Ser Thr 
        595                 600                 605             


Ser Leu Ala Pro Trp Ile Asp Phe Thr Lys Ile Phe Gly Glu Ile Asn 
    610                 615                 620                 


Ala Ser Asn Tyr Gln Leu Ile Glu Lys Ile Ile Tyr Asp Ile Ser Ile 
625                 630                 635                 640 


Phe Glu Asp Lys Lys Ile Leu Lys Arg Arg Leu Lys Lys Val Tyr Gln 
                645                 650                 655     


Leu Asp Asp Leu Leu Val Asp Lys Ile Leu Lys Leu Asn Tyr Thr Gly 
            660                 665                 670         


Trp Ser Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile Lys Ser Lys Asn 
        675                 680                 685             


Ser Lys Glu Thr Ile Leu Ser Ile Leu Glu Asn Ser Asn Met Asn Leu 
    690                 695                 700                 


Met Glu Ile Ile Asn Asp Glu Ser Leu Gly Phe Lys Gln Ile Ile Glu 
705                 710                 715                 720 


Glu Ser Asn Lys Lys Asp Ile Glu Gly Pro Phe Arg Tyr Asp Glu Val 
                725                 730                 735     


Lys Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly Ile Trp Gln Ala 
            740                 745                 750         


Leu Leu Val Val Gln Glu Ile Thr Lys Phe Met Lys His Glu Pro Ser 
        755                 760                 765             


His Ile Tyr Ile Glu Phe Ala Arg Glu Glu Gln Glu Lys Val Arg Thr 
    770                 775                 780                 


Glu Ser Arg Ile Ala Lys Leu Gln Lys Ile Tyr Lys Asp Leu Asn Leu 
785                 790                 795                 800 


Gln Thr Lys Glu Asp Gln Leu Val Tyr Glu Ser Leu Lys Lys Glu Asp 
                805                 810                 815     


Ala Lys Lys Lys Ile Asp Thr Asp Ala Leu Tyr Leu Tyr Tyr Leu Gln 
            820                 825                 830         


Met Gly Lys Ser Met Tyr Ser Gly Lys Pro Leu Asp Ile Asp Lys Leu 
        835                 840                 845             


Ser Thr Tyr His Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp 
    850                 855                 860                 


Asp Ser Leu Asp Asn Arg Val Leu Val Leu Pro Lys Glu Asn Glu Trp 
865                 870                 875                 880 


Lys Leu Asp Ser Glu Thr Val Pro Phe Glu Ile Arg Asn Lys Met Met 
                885                 890                 895     


Gly Phe Trp Gln Lys Leu His Glu Asn Gly Leu Met Ser Asn Lys Lys 
            900                 905                 910         


Phe Phe Ser Leu Ile Arg Thr Asp Phe Asn Glu Lys Asp Lys Lys Arg 
        915                 920                 925             


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val 
    930                 935                 940                 


Ala Val Ile Ile Asn Asp His Tyr Thr Asn Thr Asn Val Val Thr Val 
945                 950                 955                 960 


Arg Ala Glu Leu Ser His Gln Phe Arg Glu Arg Tyr Lys Ile Tyr Lys 
                965                 970                 975     


Asn Arg Asp Leu Asn Asp Leu His His Ala His Asp Ala Tyr Ile Ala 
            980                 985                 990         


Cys Ile Leu Gly Gln Phe Ile His  Gln Asn Phe Gly Asn  Met Asp Val 
        995                 1000                 1005             


Asn Met  Ile Tyr Gly Gln Tyr  Lys Lys Asn Tyr Lys  Lys Asp Val 
    1010                 1015                 1020             


Gln Glu  His Asn Asn Tyr Gly  Phe Ile Leu Asn Ser  Met Asn His 
    1025                 1030                 1035             


Ile His  Phe Asn Asp Asp Asn  Ser Val Ile Trp Asp  Pro Ser Tyr 
    1040                 1045                 1050             


Ile Gly  Lys Ile Lys Ser Cys  Phe Cys Tyr Lys Asp  Val Tyr Val 
    1055                 1060                 1065             


Thr Lys  Lys Leu Glu Gln Asn  Asp Ala Lys Leu Phe  Asp Leu Thr 
    1070                 1075                 1080             


Ile Leu  Pro Ser Asp Lys Asn  Ser Glu Asn Gly Val  Thr Lys Ala 
    1085                 1090                 1095             


Lys Ile  Pro Val Asn Lys Tyr  Arg Lys Asp Val Asn  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Ser Gly Asp Ala Pro  Ile Met Leu Ala Ile  Glu Ala Asp 
    1115                 1120                 1125             


Lys Gly  Lys Lys His Val Arg  Gln Val Ile Ala Phe  Pro Leu Arg 
    1130                 1135                 1140             


Leu Lys  Asn Tyr Asn Asp Glu  Glu Arg Ile Lys Phe  Ile Glu Lys 
    1145                 1150                 1155             


Glu Lys  Asn Leu Lys Asn Val  Lys Ile Leu Thr Glu  Val Lys Lys 
    1160                 1165                 1170             


Asn Gln  Leu Ile Leu Ile Asn  His Gln Tyr Phe Phe  Ile Thr Gly 
    1175                 1180                 1185             


Thr Asn  Glu Leu Val Asn Ala  Thr Gln Leu Lys Leu  Ser Ala Lys 
    1190                 1195                 1200             


Asn Thr  Lys Asn Leu Phe Asn  Leu Val Asp Ala Asn  Lys His Asn 
    1205                 1210                 1215             


Lys Leu  Glu Ser Ile Asp Asp  Ala Asn Phe Asn Glu  Val Ile Gln 
    1220                 1225                 1230             


Glu Leu  Ile Cys Lys Leu Gln  Glu Pro Ile Tyr Ser  Arg Tyr Asn 
    1235                 1240                 1245             


Ser Ile  Gly Lys Glu Phe Glu  Asp Ser Tyr Glu Lys  Ile Asn Ala 
    1250                 1255                 1260             


Val Thr  Lys Gln Asp Lys Leu  Tyr Ile Ile Glu Tyr  Leu Ile Ala 
    1265                 1270                 1275             


Ile Met  Ser Ala Lys Ala Thr  Gln Gly Tyr Ile Lys  Pro Glu Leu 
    1280                 1285                 1290             


Ala Arg  Glu Ile Gly Thr Asn  Gly Lys Asn Lys Gly  Arg Ile Lys 
    1295                 1300                 1305             


Ser Phe  Thr Ile Asp Leu Asn  Lys Thr Thr Phe Ile  Ser Thr Ser 
    1310                 1315                 1320             


Val Thr  Gly Leu Phe Ser Lys  Lys Tyr Lys Leu Gly  Lys Arg Pro 
    1325                 1330                 1335             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Gly Ser 
    1340                 1345                 1350             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Tyr Pro Tyr  Asp Val Pro 
    1355                 1360                 1365             


Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  
    1370                 1375                 1380 


<210> 6
<211> 1576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Ala Lys Asn 
        195                 200                 205             


Lys Asp Ile Arg Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
    210                 215                 220                 


Gly Trp Ala Val Met Asp Glu His Tyr Glu Leu Leu Lys Lys Gly Asn 
225                 230                 235                 240 


His His Met Trp Gly Ser Arg Leu Phe Asp Ala Ala Glu Pro Ala Ala 
                245                 250                 255     


Thr Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg 
            260                 265                 270         


Glu Arg Ile Arg Leu Leu Arg Asp Leu Leu Gly Asp Met Val Met Glu 
        275                 280                 285             


Val Asp Pro Thr Phe Phe Ile Arg Leu Leu Asn Val Ser Phe Leu Asp 
    290                 295                 300                 


Glu Glu Asp Lys Gln Lys Asn Leu Gly Asn Asp Tyr Lys Asp Asn Tyr 
305                 310                 315                 320 


Asn Leu Phe Ile Glu Lys Asp Phe Asn Asp Lys Thr Tyr Tyr Asp Lys 
                325                 330                 335     


Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Cys Glu Asn Lys Glu 
            340                 345                 350         


Lys Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys 
        355                 360                 365             


Tyr Arg Gly Asn Phe Leu Lys Glu Gly Gln Ser Phe Ala Lys Val Tyr 
    370                 375                 380                 


Glu Asp Ile Glu Glu Lys Leu Asp Asn Thr Leu Lys Lys Phe Met Ser 
385                 390                 395                 400 


Leu Asn Asp Leu Asp Asn Leu Phe Val Asp Asn Asp Ile Asn Ser Met 
                405                 410                 415     


Ile Thr Val Leu Ser Lys Ile Tyr Gln Arg Ser Lys Lys Ala Asp Asp 
            420                 425                 430         


Leu Leu Lys Ile Met Asn Pro Thr Lys Glu Glu Arg Ala Ala Tyr Lys 
        435                 440                 445             


Glu Phe Thr Lys Ala Leu Val Gly Leu Lys Phe Asn Val Ser Lys Met 
    450                 455                 460                 


Ile Leu Ala Gln Glu Val Lys Lys Asp Asp Lys Asp Ile Glu Leu Asp 
465                 470                 475                 480 


Phe Ser Asn Val Asp Tyr Asp Ser Thr Val Asp Gly Leu Gln Ala Glu 
                485                 490                 495     


Leu Gly Glu Tyr Ile Glu Phe Ile Glu Met Leu His Ser Ile Asn Ser 
            500                 505                 510         


Trp Val Glu Leu Gln Asp Ile Leu Gly Asn Asn Ser Thr Ile Ser Ala 
        515                 520                 525             


Ala Met Val Glu Arg Tyr Glu Glu His Lys Asn Asp Leu Arg Val Leu 
    530                 535                 540                 


Lys Lys Val Ile Arg Glu Glu Leu Pro Asp Lys Tyr Asn Glu Val Phe 
545                 550                 555                 560 


Arg Glu Asp Asn Pro Lys Leu His Asn Tyr Leu Gly Tyr Ile Lys Tyr 
                565                 570                 575     


Pro Lys Asn Thr Pro Val Glu Glu Phe Tyr Glu Tyr Ile Lys Arg Leu 
            580                 585                 590         


Leu Ala Lys Val Asp Thr Gly Glu Ala Arg Glu Ile Leu Glu Arg Ile 
        595                 600                 605             


Asp Leu Glu Lys Phe Met Leu Lys Gln Asn Ser Arg Thr Asn Gly Ser 
    610                 615                 620                 


Ile Pro Tyr Gln Met Gln Lys Asp Glu Met Ile Gln Ile Ile Asp Asn 
625                 630                 635                 640 


Gln Ser Val Tyr Tyr Pro Gln Leu Lys Glu Asn Arg Glu Lys Leu Ile 
                645                 650                 655     


Ser Ile Leu Glu Phe Arg Ile Pro Tyr Tyr Phe Gly Pro Leu Asn Thr 
            660                 665                 670         


His Ser Glu Phe Ala Trp Ile Lys Lys Phe Glu Asp Lys Gln Lys Glu 
        675                 680                 685             


Arg Ile Leu Pro Trp Asn Tyr Asp Gln Ile Val Asp Ile Asp Ala Thr 
    690                 695                 700                 


Ala Glu Gly Phe Ile Glu Arg Met Gln Asn Thr Gly Thr Tyr Phe Pro 
705                 710                 715                 720 


Asp Lys Pro Val Met Ala Lys Asn Ser Leu Thr Val Ser Lys Phe Glu 
                725                 730                 735     


Val Leu Asn Glu Leu Asn Lys Ile Arg Ile Asn Gly Lys Leu Ile Pro 
            740                 745                 750         


Val Glu Thr Lys Lys Glu Leu Leu Ser Asp Leu Phe Met Lys Asn Lys 
        755                 760                 765             


Thr Ile Thr Asp Lys Lys Leu Lys Asp Trp Leu Val Thr His Gln Tyr 
    770                 775                 780                 


Tyr Asp Thr Asn Glu Glu Leu Lys Ile Glu Gly Tyr Gln Lys Asp Leu 
785                 790                 795                 800 


Gln Phe Ser Thr Ser Leu Ala Pro Trp Ile Asp Phe Thr Lys Ile Phe 
                805                 810                 815     


Gly Glu Ile Asn Ala Ser Asn Tyr Gln Leu Ile Glu Lys Ile Ile Tyr 
            820                 825                 830         


Asp Ile Ser Ile Phe Glu Asp Lys Lys Ile Leu Lys Arg Arg Leu Lys 
        835                 840                 845             


Lys Val Tyr Gln Leu Asp Asp Leu Leu Val Asp Lys Ile Leu Lys Leu 
    850                 855                 860                 


Asn Tyr Thr Gly Trp Ser Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
865                 870                 875                 880 


Lys Ser Lys Asn Ser Lys Glu Thr Ile Leu Ser Ile Leu Glu Asn Ser 
                885                 890                 895     


Asn Met Asn Leu Met Glu Ile Ile Asn Asp Glu Ser Leu Gly Phe Lys 
            900                 905                 910         


Gln Ile Ile Glu Glu Ser Asn Lys Lys Asp Ile Glu Gly Pro Phe Arg 
        915                 920                 925             


Tyr Asp Glu Val Lys Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
    930                 935                 940                 


Ile Trp Gln Ala Leu Leu Val Val Gln Glu Ile Thr Lys Phe Met Lys 
945                 950                 955                 960 


His Glu Pro Ser His Ile Tyr Ile Glu Phe Ala Arg Glu Glu Gln Glu 
                965                 970                 975     


Lys Val Arg Thr Glu Ser Arg Ile Ala Lys Leu Gln Lys Ile Tyr Lys 
            980                 985                 990         


Asp Leu Asn Leu Gln Thr Lys Glu  Asp Gln Leu Val Tyr  Glu Ser Leu 
        995                 1000                 1005             


Lys Lys  Glu Asp Ala Lys Lys  Lys Ile Asp Thr Asp  Ala Leu Tyr 
    1010                 1015                 1020             


Leu Tyr  Tyr Leu Gln Met Gly  Lys Ser Met Tyr Ser  Gly Lys Pro 
    1025                 1030                 1035             


Leu Asp  Ile Asp Lys Leu Ser  Thr Tyr His Ile Asp  His Ile Leu 
    1040                 1045                 1050             


Pro Arg  Ser Leu Ile Lys Asp  Asp Ser Leu Asp Asn  Arg Val Leu 
    1055                 1060                 1065             


Val Leu  Pro Lys Glu Asn Glu  Trp Lys Leu Asp Ser  Glu Thr Val 
    1070                 1075                 1080             


Pro Phe  Glu Ile Arg Asn Lys  Met Met Gly Phe Trp  Gln Lys Leu 
    1085                 1090                 1095             


His Glu  Asn Gly Leu Met Ser  Asn Lys Lys Phe Phe  Ser Leu Ile 
    1100                 1105                 1110             


Arg Thr  Asp Phe Asn Glu Lys  Asp Lys Lys Arg Phe  Ile Asn Arg 
    1115                 1120                 1125             


Gln Leu  Val Glu Thr Arg Gln  Ile Ile Lys Asn Val  Ala Val Ile 
    1130                 1135                 1140             


Ile Asn  Asp His Tyr Thr Asn  Thr Asn Val Val Thr  Val Arg Ala 
    1145                 1150                 1155             


Glu Leu  Ser His Gln Phe Arg  Glu Arg Tyr Lys Ile  Tyr Lys Asn 
    1160                 1165                 1170             


Arg Asp  Leu Asn Asp Leu His  His Ala His Asp Ala  Tyr Ile Ala 
    1175                 1180                 1185             


Cys Ile  Leu Gly Gln Phe Ile  His Gln Asn Phe Gly  Asn Met Asp 
    1190                 1195                 1200             


Val Asn  Met Ile Tyr Gly Gln  Tyr Lys Lys Asn Tyr  Lys Lys Asp 
    1205                 1210                 1215             


Val Gln  Glu His Asn Asn Tyr  Gly Phe Ile Leu Asn  Ser Met Asn 
    1220                 1225                 1230             


His Ile  His Phe Asn Asp Asp  Asn Ser Val Ile Trp  Asp Pro Ser 
    1235                 1240                 1245             


Tyr Ile  Gly Lys Ile Lys Ser  Cys Phe Cys Tyr Lys  Asp Val Tyr 
    1250                 1255                 1260             


Val Thr  Lys Lys Leu Glu Gln  Asn Asp Ala Lys Leu  Phe Asp Leu 
    1265                 1270                 1275             


Thr Ile  Leu Pro Ser Asp Lys  Asn Ser Glu Asn Gly  Val Thr Lys 
    1280                 1285                 1290             


Ala Lys  Ile Pro Val Asn Lys  Tyr Arg Lys Asp Val  Asn Lys Tyr 
    1295                 1300                 1305             


Gly Gly  Phe Ser Gly Asp Ala  Pro Ile Met Leu Ala  Ile Glu Ala 
    1310                 1315                 1320             


Asp Lys  Gly Lys Lys His Val  Arg Gln Val Ile Ala  Phe Pro Leu 
    1325                 1330                 1335             


Arg Leu  Lys Asn Tyr Asn Asp  Glu Glu Arg Ile Lys  Phe Ile Glu 
    1340                 1345                 1350             


Lys Glu  Lys Asn Leu Lys Asn  Val Lys Ile Leu Thr  Glu Val Lys 
    1355                 1360                 1365             


Lys Asn  Gln Leu Ile Leu Ile  Asn His Gln Tyr Phe  Phe Ile Thr 
    1370                 1375                 1380             


Gly Thr  Asn Glu Leu Val Asn  Ala Thr Gln Leu Lys  Leu Ser Ala 
    1385                 1390                 1395             


Lys Asn  Thr Lys Asn Leu Phe  Asn Leu Val Asp Ala  Asn Lys His 
    1400                 1405                 1410             


Asn Lys  Leu Glu Ser Ile Asp  Asp Ala Asn Phe Asn  Glu Val Ile 
    1415                 1420                 1425             


Gln Glu  Leu Ile Cys Lys Leu  Gln Glu Pro Ile Tyr  Ser Arg Tyr 
    1430                 1435                 1440             


Asn Ser  Ile Gly Lys Glu Phe  Glu Asp Ser Tyr Glu  Lys Ile Asn 
    1445                 1450                 1455             


Ala Val  Thr Lys Gln Asp Lys  Leu Tyr Ile Ile Glu  Tyr Leu Ile 
    1460                 1465                 1470             


Ala Ile  Met Ser Ala Lys Ala  Thr Gln Gly Tyr Ile  Lys Pro Glu 
    1475                 1480                 1485             


Leu Ala  Arg Glu Ile Gly Thr  Asn Gly Lys Asn Lys  Gly Arg Ile 
    1490                 1495                 1500             


Lys Ser  Phe Thr Ile Asp Leu  Asn Lys Thr Thr Phe  Ile Ser Thr 
    1505                 1510                 1515             


Ser Val  Thr Gly Leu Phe Ser  Lys Lys Tyr Lys Leu  Gly Lys Arg 
    1520                 1525                 1530             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys Gly 
    1535                 1540                 1545             


Ser Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val 
    1550                 1555                 1560             


Pro Asp  Tyr Ala Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala 
    1565                 1570                 1575     


<210> 7
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
guuuuagagu uguguuauug aaaaauaaca caacgaguua aaauaaagcu uaugcuuaaa       60

ugccagcuuu gcugguguca uuuagaugac uuuacuaagg uugcuucggc aaccuuuuu       119


<210> 8
<211> 1409
<212> PRT
<213> Veillonella parvula

<400> 8
Met Ser Ile Ile Asn Phe Gln Arg Arg Gly Leu Met Glu Thr Gln Ala 
1               5                   10                  15      


Ser Asn Gln Leu Ile Ser Ser His Leu Lys Gly Tyr Pro Ile Lys Asp 
            20                  25                  30          


Tyr Phe Val Gly Leu Asp Ile Gly Thr Ser Ser Val Gly Trp Ala Val 
        35                  40                  45              


Thr Asn Lys Ala Tyr Glu Leu Leu Lys Phe Arg Ser His Lys Met Trp 
    50                  55                  60                  


Gly Ser Arg Leu Phe Asp Glu Gly Glu Ser Ala Val Ala Arg Arg Gly 
65                  70                  75                  80  


Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg Lys Leu Arg Leu Lys 
                85                  90                  95      


Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala Gln Val Asp Pro Thr 
            100                 105                 110         


Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His Tyr Glu Asp Lys Thr 
        115                 120                 125             


Thr Gly His Ser Ser Lys His Ile Leu Phe Ile Asp Lys Asn Tyr Asn 
    130                 135                 140                 


Asp Gln Asp Tyr Phe Lys Glu Tyr Pro Thr Val Tyr His Leu Arg Ser 
145                 150                 155                 160 


Glu Leu Met Lys Ser Gly Thr Asp Asp Ile Arg Lys Leu Phe Leu Ala 
                165                 170                 175     


Val His His Ile Leu Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Ala 
            180                 185                 190         


Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp Val Ile Lys Gln Ala 
        195                 200                 205             


Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Cys Asn Ser Ala Ile Ser 
    210                 215                 220                 


Ser Ile Gly Gln Ile Leu Met Glu Ala Gly Lys Thr Lys Ser Asp Lys 
225                 230                 235                 240 


Ala Lys Ala Ile Glu His Leu Val Asp Thr Tyr Ile Ala Thr Asp Thr 
                245                 250                 255     


Val Asp Thr Ser Ser Lys Thr Gln Lys Asp Gln Val Lys Glu Asp Lys 
            260                 265                 270         


Lys Arg Leu Lys Ala Phe Ala Asn Leu Val Leu Gly Leu Asn Ala Ser 
        275                 280                 285             


Leu Ile Asp Leu Phe Gly Ser Val Glu Glu Leu Glu Glu Asp Leu Lys 
    290                 295                 300                 


Lys Leu Gln Ile Thr Gly Asp Thr Tyr Asp Asp Lys Arg Asp Glu Leu 
305                 310                 315                 320 


Ala Lys Ala Trp Ser Asp Glu Ile Tyr Ile Ile Asp Asp Cys Lys Ser 
                325                 330                 335     


Val Tyr Asp Ala Ile Ile Leu Leu Ser Ile Lys Glu Pro Gly Leu Thr 
            340                 345                 350         


Ile Ser Glu Ser Lys Val Lys Ala Phe Asn Lys His Lys Asp Asp Leu 
        355                 360                 365             


Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg Ser Ile Tyr Asn Thr 
    370                 375                 380                 


Met Phe Lys Val Asp Glu Lys Gly Leu His Asn Tyr Val His Tyr Ile 
385                 390                 395                 400 


Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Asn Arg Glu Asp Phe Tyr 
                405                 410                 415     


Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ser Asp Ser Lys Asp Lys 
            420                 425                 430         


Glu Tyr Ile Leu Ser Gln Ile Glu Leu Gln Ile Leu Leu Pro Leu Gln 
        435                 440                 445             


Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln Leu His Leu Glu Glu 
    450                 455                 460                 


Leu Lys Ala Ile Leu Ala Lys Cys Gly Pro Lys Phe Pro Phe Leu Asn 
465                 470                 475                 480 


Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys Leu Ile Lys Met Leu 
                485                 490                 495     


Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Thr His His Asn 
            500                 505                 510         


Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg Lys Ala Ser Gly Arg 
        515                 520                 525             


Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp Arg Glu Lys Ser Ala 
    530                 535                 540                 


Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys Thr Tyr Leu Leu Gly 
545                 550                 555                 560 


Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Phe Met Leu 
                565                 570                 575     


Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly Lys Pro Leu Glu Lys 
            580                 585                 590         


Val Val Lys Glu His Leu Ile Glu Ala Val Phe Lys Gln Asp His Lys 
        595                 600                 605             


Lys Met Thr Lys Asn Arg Ile Glu Gln Phe Leu Lys Asp Asn Gly Tyr 
    610                 615                 620                 


Ile Ser Glu Thr His Lys His Glu Ile Thr Gly Leu Asp Gly Glu Ile 
625                 630                 635                 640 


Lys Asn Asp Leu Ala Ser Tyr Arg Asp Met Val Arg Ile Leu Gly Asp 
                645                 650                 655     


Gly Phe Asp Arg Ser Met Ala Glu Glu Ile Ile Thr Asp Ile Thr Ile 
            660                 665                 670         


Phe Gly Glu Ser Lys Lys Met Leu Arg Glu Thr Leu Arg Lys Lys Phe 
        675                 680                 685             


Ala Ser Cys Leu Asp Asp Glu Ala Ile Lys Lys Leu Thr Lys Leu Arg 
    690                 695                 700                 


Tyr Arg Asp Trp Gly Arg Leu Ser Gln Lys Leu Leu Asn Gly Ile Glu 
705                 710                 715                 720 


Gly Cys Asp Lys Ala Gly Asp Gly Thr Pro Glu Thr Ile Ile Ile Leu 
                725                 730                 735     


Met Arg Asn Phe Ser Tyr Asn Leu Met Glu Leu Leu Gly Asp Lys Phe 
            740                 745                 750         


Ser Phe Met Glu Arg Ile Gln Glu Ile Asn Ala Lys Leu Thr Glu Gly 
        755                 760                 765             


Gln Ile Val Asn Pro His Asp Ile Ile Asp Asp Leu Ala Leu Ser Pro 
    770                 775                 780                 


Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg Ile Val Asp Glu Val 
785                 790                 795                 800 


Ala His Ile Lys Lys Ala Leu Pro Ala Arg Ile Phe Val Glu Val Thr 
                805                 810                 815     


Arg Ser Asn Lys Asn Glu Lys Lys Lys Lys Asp Ser Arg Gln Lys Arg 
            820                 825                 830         


Leu Ser Asp Leu Tyr Ala Ala Ile Lys Lys Asp Asp Val Leu Leu Asn 
        835                 840                 845             


Gly Leu Asn Asn Glu Ile Phe Gly Glu Leu Lys Ser Ser Leu Ala Lys 
    850                 855                 860                 


Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu Tyr Leu Tyr Tyr Thr 
865                 870                 875                 880 


Gln Met Gly Arg Cys Ala Tyr Thr Gly Glu Ile Ile Glu Leu Ser Leu 
                885                 890                 895     


Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Leu 
            900                 905                 910         


Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Cys Lys Arg Thr Ala 
        915                 920                 925             


Asn Ala Gln Lys Ser Asp Ala Tyr Pro Ile Ser Glu Glu Ile Gln Lys 
    930                 935                 940                 


Thr Gln Lys Pro Phe Trp Thr Phe Leu Lys Gln Gln Gly Leu Ile Ser 
945                 950                 955                 960 


Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Thr Pro Leu Thr Ala Asp 
                965                 970                 975     


Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Asn Gln Ser 
            980                 985                 990         


Val Lys Ala Ala Thr Thr Leu Leu  Arg Arg Leu Tyr Pro  Gly Val Asp 
        995                 1000                 1005             


Val Val  Phe Val Lys Ala Glu  Asn Val Thr Asp Phe  Arg His Asp 
    1010                 1015                 1020             


Asn Asn  Phe Ile Lys Val Arg  Ser Leu Asn His His  His His Ala 
    1025                 1030                 1035             


Lys Asp  Ala Tyr Leu Asn Ile  Val Val Gly Asn Val  Tyr His Glu 
    1040                 1045                 1050             


Arg Phe  Thr Arg Asn Phe Arg  Ala Phe Phe Lys Lys  Asn Gly Ala 
    1055                 1060                 1065             


Asn Arg  Thr Tyr Asn Leu Ala  Lys Met Phe Asn Tyr  Asp Val Asn 
    1070                 1075                 1080             


Cys Thr  Asn Ala Lys Asp Gly  Lys Ala Trp Asp Val  Lys Thr Ser 
    1085                 1090                 1095             


Met Asp  Thr Val Lys Lys Met  Met Asp Ser Asn Asp  Val Arg Val 
    1100                 1105                 1110             


Thr Lys  Arg Leu Leu Glu Gln  Thr Gly Ala Leu Ala  Asp Ala Thr 
    1115                 1120                 1125             


Ile Tyr  Lys Ala Thr Val Ala  Gly Lys Ala Lys Asp  Gly Ala Tyr 
    1130                 1135                 1140             


Ile Gly  Met Lys Thr Lys Ser  Ser Val Phe Ala Asp  Val Ser Lys 
    1145                 1150                 1155             


Tyr Gly  Gly Met Thr Lys Ile  Lys Asn Ala Tyr Ser  Ile Ile Val 
    1160                 1165                 1170             


Gln Tyr  Thr Gly Lys Lys Gly  Glu Val Ile Lys Glu  Ile Val Pro 
    1175                 1180                 1185             


Leu Pro  Ile Tyr Leu Thr Asn  Arg Asn Thr Thr Asp  Gln Asp Leu 
    1190                 1195                 1200             


Ile Asn  Tyr Val Ala Ser Ile  Ile Pro Gln Ala Lys  Asp Ile Ser 
    1205                 1210                 1215             


Ile Ile  Tyr Gly Lys Leu Cys  Ile Asn Gln Leu Val  Lys Val Asn 
    1220                 1225                 1230             


Gly Phe  Tyr Tyr Tyr Leu Gly  Gly Lys Thr Asn Ser  Lys Phe Cys 
    1235                 1240                 1245             


Ile Asp  Asn Ala Ile Gln Val  Ile Val Ser Asn Glu  Trp Ile Pro 
    1250                 1255                 1260             


Tyr Leu  Lys Val Leu Glu Lys  Phe Asn Asn Met Arg  Lys Asp Asn 
    1265                 1270                 1275             


Lys Asp  Leu Lys Ala Asn Val  Val Ser Thr Arg Ala  Leu Asp Asn 
    1280                 1285                 1290             


Lys His  Thr Ile Glu Val Arg  Ile Val Glu Glu Lys  Asn Ile Glu 
    1295                 1300                 1305             


Phe Phe  Asp Tyr Leu Val Ser  Lys Leu Lys Met Pro  Ile Tyr Gln 
    1310                 1315                 1320             


Lys Met  Lys Gly Asn Lys Ala  Ala Glu Leu Ser Glu  Lys Gly Tyr 
    1325                 1330                 1335             


Gly Leu  Phe Lys Lys Met Ser  Leu Glu Glu Gln Ser  Ile His Leu 
    1340                 1345                 1350             


Ile Glu  Leu Leu Asn Leu Leu  Thr Asn Gln Lys Thr  Thr Phe Glu 
    1355                 1360                 1365             


Val Lys  Pro Leu Gly Ile Thr  Ala Ser Arg Ser Thr  Val Gly Ser 
    1370                 1375                 1380             


Lys Ile  Ser Asn Gln Asp Glu  Phe Lys Val Ile Asn  Glu Ser Ile 
    1385                 1390                 1395             


Thr Gly  Leu Tyr Ser Asn Glu  Val Thr Ile Val 
    1400                 1405                 


<210> 9
<211> 1463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Pro Lys Lys Lys Arg Lys Val Gly Ser Ile Ile Asn Phe Gln Arg 
1               5                   10                  15      


Arg Gly Leu Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His 
            20                  25                  30          


Leu Lys Gly Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Asp Ile Gly 
        35                  40                  45              


Thr Ser Ser Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu 
    50                  55                  60                  


Lys Phe Arg Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly 
65                  70                  75                  80  


Glu Ser Ala Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu 
                85                  90                  95      


Glu Arg Arg Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp 
            100                 105                 110         


Ala Met Ala Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser 
        115                 120                 125             


Lys Tyr His Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile 
    130                 135                 140                 


Leu Phe Ile Asp Lys Asn Tyr Asn Asp Gln Asp Tyr Phe Lys Glu Tyr 
145                 150                 155                 160 


Pro Thr Val Tyr His Leu Arg Ser Glu Leu Met Lys Ser Gly Thr Asp 
                165                 170                 175     


Asp Ile Arg Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg 
            180                 185                 190         


Gly Asn Phe Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr 
        195                 200                 205             


Leu Asp Asp Val Ile Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys 
    210                 215                 220                 


Phe Asp Cys Asn Ser Ala Ile Ser Ser Ile Gly Gln Ile Leu Met Glu 
225                 230                 235                 240 


Ala Gly Lys Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu His Leu Val 
                245                 250                 255     


Asp Thr Tyr Ile Ala Thr Asp Thr Val Asp Thr Ser Ser Lys Thr Gln 
            260                 265                 270         


Lys Asp Gln Val Lys Glu Asp Lys Lys Arg Leu Lys Ala Phe Ala Asn 
        275                 280                 285             


Leu Val Leu Gly Leu Asn Ala Ser Leu Ile Asp Leu Phe Gly Ser Val 
    290                 295                 300                 


Glu Glu Leu Glu Glu Asp Leu Lys Lys Leu Gln Ile Thr Gly Asp Thr 
305                 310                 315                 320 


Tyr Asp Asp Lys Arg Asp Glu Leu Ala Lys Ala Trp Ser Asp Glu Ile 
                325                 330                 335     


Tyr Ile Ile Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Leu 
            340                 345                 350         


Ser Ile Lys Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala 
        355                 360                 365             


Phe Asn Lys His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys 
    370                 375                 380                 


Ser Asp Arg Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly 
385                 390                 395                 400 


Leu His Asn Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr 
                405                 410                 415     


Ser Cys Asn Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu 
            420                 425                 430         


Gly Leu Ser Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Gln Ile Glu 
        435                 440                 445             


Leu Gln Ile Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile 
    450                 455                 460                 


Pro Tyr Gln Leu His Leu Glu Glu Leu Lys Ala Ile Leu Ala Lys Cys 
465                 470                 475                 480 


Gly Pro Lys Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val 
                485                 490                 495     


Ala Glu Lys Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val 
            500                 505                 510         


Gly Pro Leu Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp 
        515                 520                 525             


Ala Val Arg Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp 
    530                 535                 540                 


Lys Ile Asp Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr 
545                 550                 555                 560 


Asn Lys Cys Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser 
                565                 570                 575     


Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg 
            580                 585                 590         


Ile Asp Gly Lys Pro Leu Glu Lys Val Val Lys Glu His Leu Ile Glu 
        595                 600                 605             


Ala Val Phe Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu 
    610                 615                 620                 


Gln Phe Leu Lys Asp Asn Gly Tyr Ile Ser Glu Thr His Lys His Glu 
625                 630                 635                 640 


Ile Thr Gly Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg 
                645                 650                 655     


Asp Met Val Arg Ile Leu Gly Asp Gly Phe Asp Arg Ser Met Ala Glu 
            660                 665                 670         


Glu Ile Ile Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu 
        675                 680                 685             


Arg Glu Thr Leu Arg Lys Lys Phe Ala Ser Cys Leu Asp Asp Glu Ala 
    690                 695                 700                 


Ile Lys Lys Leu Thr Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser 
705                 710                 715                 720 


Gln Lys Leu Leu Asn Gly Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly 
                725                 730                 735     


Thr Pro Glu Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu 
            740                 745                 750         


Met Glu Leu Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu 
        755                 760                 765             


Ile Asn Ala Lys Leu Thr Glu Gly Gln Ile Val Asn Pro His Asp Ile 
    770                 775                 780                 


Ile Asp Asp Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln 
785                 790                 795                 800 


Ala Leu Arg Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro 
                805                 810                 815     


Ala Arg Ile Phe Val Glu Val Thr Arg Ser Asn Lys Asn Glu Lys Lys 
            820                 825                 830         


Lys Lys Asp Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile 
        835                 840                 845             


Lys Lys Asp Asp Val Leu Leu Asn Gly Leu Asn Asn Glu Ile Phe Gly 
    850                 855                 860                 


Glu Leu Lys Ser Ser Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser 
865                 870                 875                 880 


Lys Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr 
                885                 890                 895     


Gly Glu Ile Ile Glu Leu Ser Leu Leu Asn Thr Asp Asn Tyr Asp Ile 
            900                 905                 910         


Asp His Ile Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn 
        915                 920                 925             


Leu Val Leu Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Ala Tyr 
    930                 935                 940                 


Pro Ile Ser Glu Glu Ile Gln Lys Thr Gln Lys Pro Phe Trp Thr Phe 
945                 950                 955                 960 


Leu Lys Gln Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr 
                965                 970                 975     


Arg Ile Thr Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg 
            980                 985                 990         


Gln Leu Val Glu Thr Asn Gln Ser  Val Lys Ala Ala Thr  Thr Leu Leu 
        995                 1000                 1005             


Arg Arg  Leu Tyr Pro Gly Val  Asp Val Val Phe Val  Lys Ala Glu 
    1010                 1015                 1020             


Asn Val  Thr Asp Phe Arg His  Asp Asn Asn Phe Ile  Lys Val Arg 
    1025                 1030                 1035             


Ser Leu  Asn His His His His  Ala Lys Asp Ala Tyr  Leu Asn Ile 
    1040                 1045                 1050             


Val Val  Gly Asn Val Tyr His  Glu Arg Phe Thr Arg  Asn Phe Arg 
    1055                 1060                 1065             


Ala Phe  Phe Lys Lys Asn Gly  Ala Asn Arg Thr Tyr  Asn Leu Ala 
    1070                 1075                 1080             


Lys Met  Phe Asn Tyr Asp Val  Asn Cys Thr Asn Ala  Lys Asp Gly 
    1085                 1090                 1095             


Lys Ala  Trp Asp Val Lys Thr  Ser Met Asp Thr Val  Lys Lys Met 
    1100                 1105                 1110             


Met Asp  Ser Asn Asp Val Arg  Val Thr Lys Arg Leu  Leu Glu Gln 
    1115                 1120                 1125             


Thr Gly  Ala Leu Ala Asp Ala  Thr Ile Tyr Lys Ala  Thr Val Ala 
    1130                 1135                 1140             


Gly Lys  Ala Lys Asp Gly Ala  Tyr Ile Gly Met Lys  Thr Lys Ser 
    1145                 1150                 1155             


Ser Val  Phe Ala Asp Val Ser  Lys Tyr Gly Gly Met  Thr Lys Ile 
    1160                 1165                 1170             


Lys Asn  Ala Tyr Ser Ile Ile  Val Gln Tyr Thr Gly  Lys Lys Gly 
    1175                 1180                 1185             


Glu Val  Ile Lys Glu Ile Val  Pro Leu Pro Ile Tyr  Leu Thr Asn 
    1190                 1195                 1200             


Arg Asn  Thr Thr Asp Gln Asp  Leu Ile Asn Tyr Val  Ala Ser Ile 
    1205                 1210                 1215             


Ile Pro  Gln Ala Lys Asp Ile  Ser Ile Ile Tyr Gly  Lys Leu Cys 
    1220                 1225                 1230             


Ile Asn  Gln Leu Val Lys Val  Asn Gly Phe Tyr Tyr  Tyr Leu Gly 
    1235                 1240                 1245             


Gly Lys  Thr Asn Ser Lys Phe  Cys Ile Asp Asn Ala  Ile Gln Val 
    1250                 1255                 1260             


Ile Val  Ser Asn Glu Trp Ile  Pro Tyr Leu Lys Val  Leu Glu Lys 
    1265                 1270                 1275             


Phe Asn  Asn Met Arg Lys Asp  Asn Lys Asp Leu Lys  Ala Asn Val 
    1280                 1285                 1290             


Val Ser  Thr Arg Ala Leu Asp  Asn Lys His Thr Ile  Glu Val Arg 
    1295                 1300                 1305             


Ile Val  Glu Glu Lys Asn Ile  Glu Phe Phe Asp Tyr  Leu Val Ser 
    1310                 1315                 1320             


Lys Leu  Lys Met Pro Ile Tyr  Gln Lys Met Lys Gly  Asn Lys Ala 
    1325                 1330                 1335             


Ala Glu  Leu Ser Glu Lys Gly  Tyr Gly Leu Phe Lys  Lys Met Ser 
    1340                 1345                 1350             


Leu Glu  Glu Gln Ser Ile His  Leu Ile Glu Leu Leu  Asn Leu Leu 
    1355                 1360                 1365             


Thr Asn  Gln Lys Thr Thr Phe  Glu Val Lys Pro Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ala Ser  Arg Ser Thr Val Gly  Ser Lys Ile Ser Asn  Gln Asp Glu 
    1385                 1390                 1395             


Phe Lys  Val Ile Asn Glu Ser  Ile Thr Gly Leu Tyr  Ser Asn Glu 
    1400                 1405                 1410             


Val Thr  Ile Val Gly Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    1415                 1420                 1425             


Gln Ala  Lys Lys Lys Lys Gly  Ser Tyr Pro Tyr Asp  Val Pro Asp 
    1430                 1435                 1440             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1445                 1450                 1455             


Val Pro  Asp Tyr Ala 
    1460             


<210> 10
<211> 1659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Ser Ile Ile 
        195                 200                 205             


Asn Phe Gln Arg Arg Gly Leu Met Glu Thr Gln Ala Ser Asn Gln Leu 
    210                 215                 220                 


Ile Ser Ser His Leu Lys Gly Tyr Pro Ile Lys Asp Tyr Phe Val Gly 
225                 230                 235                 240 


Leu Ala Ile Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asn Lys Ala 
                245                 250                 255     


Tyr Glu Leu Leu Lys Phe Arg Ser His Lys Met Trp Gly Ser Arg Leu 
            260                 265                 270         


Phe Asp Glu Gly Glu Ser Ala Val Ala Arg Arg Gly Phe Arg Ser Met 
        275                 280                 285             


Arg Arg Arg Leu Glu Arg Arg Lys Leu Arg Leu Lys Leu Leu Glu Glu 
    290                 295                 300                 


Leu Phe Ala Asp Ala Met Ala Gln Val Asp Pro Thr Phe Phe Met Arg 
305                 310                 315                 320 


Leu Arg Glu Ser Lys Tyr His Tyr Glu Asp Lys Thr Thr Gly His Ser 
                325                 330                 335     


Ser Lys His Ile Leu Phe Ile Asp Lys Asn Tyr Asn Asp Gln Asp Tyr 
            340                 345                 350         


Phe Lys Glu Tyr Pro Thr Val Tyr His Leu Arg Ser Glu Leu Met Lys 
        355                 360                 365             


Ser Gly Thr Asp Asp Ile Arg Lys Leu Phe Leu Ala Val His His Ile 
    370                 375                 380                 


Leu Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Ala Thr Phe Asp Ser 
385                 390                 395                 400 


Asn Ala Ser Thr Leu Asp Asp Val Ile Lys Gln Ala Leu Glu Asn Ile 
                405                 410                 415     


Thr Phe Asn Cys Phe Asp Cys Asn Ser Ala Ile Ser Ser Ile Gly Gln 
            420                 425                 430         


Ile Leu Met Glu Ala Gly Lys Thr Lys Ser Asp Lys Ala Lys Ala Ile 
        435                 440                 445             


Glu His Leu Val Asp Thr Tyr Ile Ala Thr Asp Thr Val Asp Thr Ser 
    450                 455                 460                 


Ser Lys Thr Gln Lys Asp Gln Val Lys Glu Asp Lys Lys Arg Leu Lys 
465                 470                 475                 480 


Ala Phe Ala Asn Leu Val Leu Gly Leu Asn Ala Ser Leu Ile Asp Leu 
                485                 490                 495     


Phe Gly Ser Val Glu Glu Leu Glu Glu Asp Leu Lys Lys Leu Gln Ile 
            500                 505                 510         


Thr Gly Asp Thr Tyr Asp Asp Lys Arg Asp Glu Leu Ala Lys Ala Trp 
        515                 520                 525             


Ser Asp Glu Ile Tyr Ile Ile Asp Asp Cys Lys Ser Val Tyr Asp Ala 
    530                 535                 540                 


Ile Ile Leu Leu Ser Ile Lys Glu Pro Gly Leu Thr Ile Ser Glu Ser 
545                 550                 555                 560 


Lys Val Lys Ala Phe Asn Lys His Lys Asp Asp Leu Ala Ile Leu Lys 
                565                 570                 575     


Ser Leu Leu Lys Ser Asp Arg Ser Ile Tyr Asn Thr Met Phe Lys Val 
            580                 585                 590         


Asp Glu Lys Gly Leu His Asn Tyr Val His Tyr Ile Lys Gln Gly Arg 
        595                 600                 605             


Thr Glu Glu Thr Ser Cys Asn Arg Glu Asp Phe Tyr Lys Tyr Thr Lys 
    610                 615                 620                 


Lys Ile Val Glu Gly Leu Ser Asp Ser Lys Asp Lys Glu Tyr Ile Leu 
625                 630                 635                 640 


Ser Gln Ile Glu Leu Gln Ile Leu Leu Pro Leu Gln Arg Ile Lys Asp 
                645                 650                 655     


Asn Gly Val Ile Pro Tyr Gln Leu His Leu Glu Glu Leu Lys Ala Ile 
            660                 665                 670         


Leu Ala Lys Cys Gly Pro Lys Phe Pro Phe Leu Asn Glu Val Ala Asp 
        675                 680                 685             


Gly Phe Ser Val Ala Glu Lys Leu Ile Lys Met Leu Glu Phe Arg Ile 
    690                 695                 700                 


Pro Tyr Tyr Val Gly Pro Leu Asn Thr His His Asn Val Asp Asn Gly 
705                 710                 715                 720 


Gly Phe Ala Trp Ala Val Arg Lys Ala Ser Gly Arg Val Thr Pro Trp 
                725                 730                 735     


Asn Phe Asp Asp Lys Ile Asp Arg Glu Lys Ser Ala Ala Ala Phe Ile 
            740                 745                 750         


Lys Asn Leu Thr Asn Lys Cys Thr Tyr Leu Leu Gly Glu Asp Val Leu 
        755                 760                 765             


Pro Lys Ser Ser Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu 
    770                 775                 780                 


Asn Asn Val Arg Ile Asp Gly Lys Pro Leu Glu Lys Val Val Lys Glu 
785                 790                 795                 800 


His Leu Ile Glu Ala Val Phe Lys Gln Asp His Lys Lys Met Thr Lys 
                805                 810                 815     


Asn Arg Ile Glu Gln Phe Leu Lys Asp Asn Gly Tyr Ile Ser Glu Thr 
            820                 825                 830         


His Lys His Glu Ile Thr Gly Leu Asp Gly Glu Ile Lys Asn Asp Leu 
        835                 840                 845             


Ala Ser Tyr Arg Asp Met Val Arg Ile Leu Gly Asp Gly Phe Asp Arg 
    850                 855                 860                 


Ser Met Ala Glu Glu Ile Ile Thr Asp Ile Thr Ile Phe Gly Glu Ser 
865                 870                 875                 880 


Lys Lys Met Leu Arg Glu Thr Leu Arg Lys Lys Phe Ala Ser Cys Leu 
                885                 890                 895     


Asp Asp Glu Ala Ile Lys Lys Leu Thr Lys Leu Arg Tyr Arg Asp Trp 
            900                 905                 910         


Gly Arg Leu Ser Gln Lys Leu Leu Asn Gly Ile Glu Gly Cys Asp Lys 
        915                 920                 925             


Ala Gly Asp Gly Thr Pro Glu Thr Ile Ile Ile Leu Met Arg Asn Phe 
    930                 935                 940                 


Ser Tyr Asn Leu Met Glu Leu Leu Gly Asp Lys Phe Ser Phe Met Glu 
945                 950                 955                 960 


Arg Ile Gln Glu Ile Asn Ala Lys Leu Thr Glu Gly Gln Ile Val Asn 
                965                 970                 975     


Pro His Asp Ile Ile Asp Asp Leu Ala Leu Ser Pro Ala Val Lys Arg 
            980                 985                 990         


Ala Val Trp Gln Ala Leu Arg Ile  Val Asp Glu Val Ala  His Ile Lys 
        995                 1000                 1005             


Lys Ala  Leu Pro Ala Arg Ile  Phe Val Glu Val Thr  Arg Ser Asn 
    1010                 1015                 1020             


Lys Asn  Glu Lys Lys Lys Lys  Asp Ser Arg Gln Lys  Arg Leu Ser 
    1025                 1030                 1035             


Asp Leu  Tyr Ala Ala Ile Lys  Lys Asp Asp Val Leu  Leu Asn Gly 
    1040                 1045                 1050             


Leu Asn  Asn Glu Ile Phe Gly  Glu Leu Lys Ser Ser  Leu Ala Lys 
    1055                 1060                 1065             


Tyr Asp  Asp Ala Ala Leu Arg  Ser Lys Lys Leu Tyr  Leu Tyr Tyr 
    1070                 1075                 1080             


Thr Gln  Met Gly Arg Cys Ala  Tyr Thr Gly Glu Ile  Ile Glu Leu 
    1085                 1090                 1095             


Ser Leu  Leu Asn Thr Asp Asn  Tyr Asp Ile Asp His  Ile Tyr Pro 
    1100                 1105                 1110             


Arg Ser  Leu Thr Lys Asp Asp  Ser Phe Asp Asn Leu  Val Leu Cys 
    1115                 1120                 1125             


Lys Arg  Thr Ala Asn Ala Gln  Lys Ser Asp Ala Tyr  Pro Ile Ser 
    1130                 1135                 1140             


Glu Glu  Ile Gln Lys Thr Gln  Lys Pro Phe Trp Thr  Phe Leu Lys 
    1145                 1150                 1155             


Gln Gln  Gly Leu Ile Ser Glu  Arg Lys Tyr Glu Arg  Leu Thr Arg 
    1160                 1165                 1170             


Ile Thr  Pro Leu Thr Ala Asp  Asp Leu Ser Gly Phe  Ile Ala Arg 
    1175                 1180                 1185             


Gln Leu  Val Glu Thr Asn Gln  Ser Val Lys Ala Ala  Thr Thr Leu 
    1190                 1195                 1200             


Leu Arg  Arg Leu Tyr Pro Gly  Val Asp Val Val Phe  Val Lys Ala 
    1205                 1210                 1215             


Glu Asn  Val Thr Asp Phe Arg  His Asp Asn Asn Phe  Ile Lys Val 
    1220                 1225                 1230             


Arg Ser  Leu Asn His His His  His Ala Lys Asp Ala  Tyr Leu Asn 
    1235                 1240                 1245             


Ile Val  Val Gly Asn Val Tyr  His Glu Arg Phe Thr  Arg Asn Phe 
    1250                 1255                 1260             


Arg Ala  Phe Phe Lys Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu 
    1265                 1270                 1275             


Ala Lys  Met Phe Asn Tyr Asp  Val Asn Cys Thr Asn  Ala Lys Asp 
    1280                 1285                 1290             


Gly Lys  Ala Trp Asp Val Lys  Thr Ser Met Asp Thr  Val Lys Lys 
    1295                 1300                 1305             


Met Met  Asp Ser Asn Asp Val  Arg Val Thr Lys Arg  Leu Leu Glu 
    1310                 1315                 1320             


Gln Thr  Gly Ala Leu Ala Asp  Ala Thr Ile Tyr Lys  Ala Thr Val 
    1325                 1330                 1335             


Ala Gly  Lys Ala Lys Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys 
    1340                 1345                 1350             


Ser Ser  Val Phe Ala Asp Val  Ser Lys Tyr Gly Gly  Met Thr Lys 
    1355                 1360                 1365             


Ile Lys  Asn Ala Tyr Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys 
    1370                 1375                 1380             


Gly Glu  Val Ile Lys Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Thr 
    1385                 1390                 1395             


Asn Arg  Asn Thr Thr Asp Gln  Asp Leu Ile Asn Tyr  Val Ala Ser 
    1400                 1405                 1410             


Ile Ile  Pro Gln Ala Lys Asp  Ile Ser Ile Ile Tyr  Gly Lys Leu 
    1415                 1420                 1425             


Cys Ile  Asn Gln Leu Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu 
    1430                 1435                 1440             


Gly Gly  Lys Thr Asn Ser Lys  Phe Cys Ile Asp Asn  Ala Ile Gln 
    1445                 1450                 1455             


Val Ile  Val Ser Asn Glu Trp  Ile Pro Tyr Leu Lys  Val Leu Glu 
    1460                 1465                 1470             


Lys Phe  Asn Asn Met Arg Lys  Asp Asn Lys Asp Leu  Lys Ala Asn 
    1475                 1480                 1485             


Val Val  Ser Thr Arg Ala Leu  Asp Asn Lys His Thr  Ile Glu Val 
    1490                 1495                 1500             


Arg Ile  Val Glu Glu Lys Asn  Ile Glu Phe Phe Asp  Tyr Leu Val 
    1505                 1510                 1515             


Ser Lys  Leu Lys Met Pro Ile  Tyr Gln Lys Met Lys  Gly Asn Lys 
    1520                 1525                 1530             


Ala Ala  Glu Leu Ser Glu Lys  Gly Tyr Gly Leu Phe  Lys Lys Met 
    1535                 1540                 1545             


Ser Leu  Glu Glu Gln Ser Ile  His Leu Ile Glu Leu  Leu Asn Leu 
    1550                 1555                 1560             


Leu Thr  Asn Gln Lys Thr Thr  Phe Glu Val Lys Pro  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ala  Ser Arg Ser Thr Val  Gly Ser Lys Ile Ser  Asn Gln Asp 
    1580                 1585                 1590             


Glu Phe  Lys Val Ile Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn 
    1595                 1600                 1605             


Glu Val  Thr Ile Val Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1610                 1615                 1620             


Gly Gln  Ala Lys Lys Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro 
    1625                 1630                 1635             


Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr 
    1640                 1645                 1650             


Asp Val  Pro Asp Tyr Ala 
    1655                 


<210> 11
<211> 1654
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Pro Lys Lys Lys Arg Lys Val Ser Ile Ile Asn Phe Gln Arg Arg 
1               5                   10                  15      


Gly Leu Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His Leu 
            20                  25                  30          


Lys Gly Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Ser Ser Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu Lys 
    50                  55                  60                  


Phe Arg Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly Glu 
65                  70                  75                  80  


Ser Ala Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu 
                85                  90                  95      


Arg Arg Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala 
            100                 105                 110         


Met Ala Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys 
        115                 120                 125             


Tyr His Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu 
    130                 135                 140                 


Phe Ile Asp Lys Asn Tyr Asn Asp Gln Asp Tyr Phe Lys Glu Tyr Pro 
145                 150                 155                 160 


Thr Val Tyr His Leu Arg Ser Glu Leu Met Lys Ser Gly Thr Asp Asp 
                165                 170                 175     


Ile Arg Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly 
            180                 185                 190         


Asn Phe Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu 
        195                 200                 205             


Asp Asp Val Ile Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe 
    210                 215                 220                 


Asp Cys Asn Ser Ala Ile Ser Ser Ile Gly Gln Ile Leu Met Glu Ala 
225                 230                 235                 240 


Gly Lys Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu His Leu Val Asp 
                245                 250                 255     


Thr Tyr Ile Ala Thr Asp Thr Val Asp Thr Ser Ser Lys Thr Gln Lys 
            260                 265                 270         


Asp Gln Val Lys Glu Asp Lys Lys Arg Leu Lys Ala Phe Ala Asn Leu 
        275                 280                 285             


Val Leu Gly Leu Asn Ala Ser Leu Ile Asp Leu Phe Gly Ser Val Glu 
    290                 295                 300                 


Glu Leu Glu Glu Asp Leu Lys Lys Leu Gln Ile Thr Gly Asp Thr Tyr 
305                 310                 315                 320 


Asp Asp Lys Arg Asp Glu Leu Ala Lys Ala Trp Ser Asp Glu Ile Tyr 
                325                 330                 335     


Ile Ile Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Leu Ser 
            340                 345                 350         


Ile Lys Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe 
        355                 360                 365             


Asn Lys His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser 
    370                 375                 380                 


Asp Arg Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu 
385                 390                 395                 400 


His Asn Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser 
                405                 410                 415     


Cys Asn Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly 
            420                 425                 430         


Leu Ser Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Gln Ile Glu Leu 
        435                 440                 445             


Gln Ile Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro 
    450                 455                 460                 


Tyr Gln Leu His Leu Glu Glu Leu Lys Ala Ile Leu Ala Lys Cys Gly 
465                 470                 475                 480 


Pro Lys Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala 
                485                 490                 495     


Glu Lys Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly 
            500                 505                 510         


Pro Leu Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala 
        515                 520                 525             


Val Arg Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys 
    530                 535                 540                 


Ile Asp Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn 
545                 550                 555                 560 


Lys Cys Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu 
                565                 570                 575     


Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile 
            580                 585                 590         


Asp Gly Lys Pro Leu Glu Lys Val Val Lys Glu His Leu Ile Glu Ala 
        595                 600                 605             


Val Phe Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Gln 
    610                 615                 620                 


Phe Leu Lys Asp Asn Gly Tyr Ile Ser Glu Thr His Lys His Glu Ile 
625                 630                 635                 640 


Thr Gly Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg Asp 
                645                 650                 655     


Met Val Arg Ile Leu Gly Asp Gly Phe Asp Arg Ser Met Ala Glu Glu 
            660                 665                 670         


Ile Ile Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg 
        675                 680                 685             


Glu Thr Leu Arg Lys Lys Phe Ala Ser Cys Leu Asp Asp Glu Ala Ile 
    690                 695                 700                 


Lys Lys Leu Thr Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Gln 
705                 710                 715                 720 


Lys Leu Leu Asn Gly Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly Thr 
                725                 730                 735     


Pro Glu Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu Met 
            740                 745                 750         


Glu Leu Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu Ile 
        755                 760                 765             


Asn Ala Lys Leu Thr Glu Gly Gln Ile Val Asn Pro His Asp Ile Ile 
    770                 775                 780                 


Asp Asp Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala 
785                 790                 795                 800 


Leu Arg Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ala 
                805                 810                 815     


Arg Ile Phe Val Glu Val Thr Arg Ser Asn Lys Asn Glu Lys Lys Lys 
            820                 825                 830         


Lys Asp Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile Lys 
        835                 840                 845             


Lys Asp Asp Val Leu Leu Asn Gly Leu Asn Asn Glu Ile Phe Gly Glu 
    850                 855                 860                 


Leu Lys Ser Ser Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser Lys 
865                 870                 875                 880 


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly 
                885                 890                 895     


Glu Ile Ile Glu Leu Ser Leu Leu Asn Thr Asp Asn Tyr Asp Ile Asp 
            900                 905                 910         


His Ile Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu 
        915                 920                 925             


Val Leu Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Ala Tyr Pro 
    930                 935                 940                 


Ile Ser Glu Glu Ile Gln Lys Thr Gln Lys Pro Phe Trp Thr Phe Leu 
945                 950                 955                 960 


Lys Gln Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg 
                965                 970                 975     


Ile Thr Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln 
            980                 985                 990         


Leu Val Glu Thr Asn Gln Ser Val  Lys Ala Ala Thr Thr  Leu Leu Arg 
        995                 1000                 1005             


Arg Leu  Tyr Pro Gly Val Asp  Val Val Phe Val Lys  Ala Glu Asn 
    1010                 1015                 1020             


Val Thr  Asp Phe Arg His Asp  Asn Asn Phe Ile Lys  Val Arg Ser 
    1025                 1030                 1035             


Leu Asn  His His His His Ala  Lys Asp Ala Tyr Leu  Asn Ile Val 
    1040                 1045                 1050             


Val Gly  Asn Val Tyr His Glu  Arg Phe Thr Arg Asn  Phe Arg Ala 
    1055                 1060                 1065             


Phe Phe  Lys Lys Asn Gly Ala  Asn Arg Thr Tyr Asn  Leu Ala Lys 
    1070                 1075                 1080             


Met Phe  Asn Tyr Asp Val Asn  Cys Thr Asn Ala Lys  Asp Gly Lys 
    1085                 1090                 1095             


Ala Trp  Asp Val Lys Thr Ser  Met Asp Thr Val Lys  Lys Met Met 
    1100                 1105                 1110             


Asp Ser  Asn Asp Val Arg Val  Thr Lys Arg Leu Leu  Glu Gln Thr 
    1115                 1120                 1125             


Gly Ala  Leu Ala Asp Ala Thr  Ile Tyr Lys Ala Thr  Val Ala Gly 
    1130                 1135                 1140             


Lys Ala  Lys Asp Gly Ala Tyr  Ile Gly Met Lys Thr  Lys Ser Ser 
    1145                 1150                 1155             


Val Phe  Ala Asp Val Ser Lys  Tyr Gly Gly Met Thr  Lys Ile Lys 
    1160                 1165                 1170             


Asn Ala  Tyr Ser Ile Ile Val  Gln Tyr Thr Gly Lys  Lys Gly Glu 
    1175                 1180                 1185             


Val Ile  Lys Glu Ile Val Pro  Leu Pro Ile Tyr Leu  Thr Asn Arg 
    1190                 1195                 1200             


Asn Thr  Thr Asp Gln Asp Leu  Ile Asn Tyr Val Ala  Ser Ile Ile 
    1205                 1210                 1215             


Pro Gln  Ala Lys Asp Ile Ser  Ile Ile Tyr Gly Lys  Leu Cys Ile 
    1220                 1225                 1230             


Asn Gln  Leu Val Lys Val Asn  Gly Phe Tyr Tyr Tyr  Leu Gly Gly 
    1235                 1240                 1245             


Lys Thr  Asn Ser Lys Phe Cys  Ile Asp Asn Ala Ile  Gln Val Ile 
    1250                 1255                 1260             


Val Ser  Asn Glu Trp Ile Pro  Tyr Leu Lys Val Leu  Glu Lys Phe 
    1265                 1270                 1275             


Asn Asn  Met Arg Lys Asp Asn  Lys Asp Leu Lys Ala  Asn Val Val 
    1280                 1285                 1290             


Ser Thr  Arg Ala Leu Asp Asn  Lys His Thr Ile Glu  Val Arg Ile 
    1295                 1300                 1305             


Val Glu  Glu Lys Asn Ile Glu  Phe Phe Asp Tyr Leu  Val Ser Lys 
    1310                 1315                 1320             


Leu Lys  Met Pro Ile Tyr Gln  Lys Met Lys Gly Asn  Lys Ala Ala 
    1325                 1330                 1335             


Glu Leu  Ser Glu Lys Gly Tyr  Gly Leu Phe Lys Lys  Met Ser Leu 
    1340                 1345                 1350             


Glu Glu  Gln Ser Ile His Leu  Ile Glu Leu Leu Asn  Leu Leu Thr 
    1355                 1360                 1365             


Asn Gln  Lys Thr Thr Phe Glu  Val Lys Pro Leu Gly  Ile Thr Ala 
    1370                 1375                 1380             


Ser Arg  Ser Thr Val Gly Ser  Lys Ile Ser Asn Gln  Asp Glu Phe 
    1385                 1390                 1395             


Lys Val  Ile Asn Glu Ser Ile  Thr Gly Leu Tyr Ser  Asn Glu Val 
    1400                 1405                 1410             


Thr Ile  Val Lys Arg Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala 
    1415                 1420                 1425             


Lys Lys  Lys Lys Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1430                 1435                 1440             


Ala Thr  Pro Glu Ser Ser Gly  Ser Glu Val Glu Phe  Ser His Glu 
    1445                 1450                 1455             


Tyr Trp  Met Arg His Ala Leu  Thr Leu Ala Lys Arg  Ala Arg Asp 
    1460                 1465                 1470             


Glu Arg  Glu Val Pro Val Gly  Ala Val Leu Val Leu  Asn Asn Arg 
    1475                 1480                 1485             


Val Ile  Gly Glu Gly Trp Asn  Arg Ala Ile Gly Leu  His Asp Pro 
    1490                 1495                 1500             


Thr Ala  His Ala Glu Ile Met  Ala Leu Arg Gln Gly  Gly Leu Val 
    1505                 1510                 1515             


Met Gln  Asn Tyr Arg Leu Tyr  Asp Ala Thr Leu Tyr  Val Thr Phe 
    1520                 1525                 1530             


Glu Pro  Cys Val Met Cys Ala  Gly Ala Met Ile His  Ser Arg Ile 
    1535                 1540                 1545             


Gly Arg  Val Val Phe Gly Val  Arg Asn Ala Lys Thr  Gly Ala Ala 
    1550                 1555                 1560             


Gly Ser  Leu Met Asp Val Leu  His His Pro Gly Met  Asn His Arg 
    1565                 1570                 1575             


Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp Glu Cys  Ala Ala Leu 
    1580                 1585                 1590             


Leu Cys  Arg Phe Phe Arg Met  Pro Arg Arg Val Phe  Asn Ala Gln 
    1595                 1600                 1605             


Lys Lys  Ala Gln Ser Ser Thr  Asp Pro Ala Ala Lys  Arg Val Lys 
    1610                 1615                 1620             


Leu Asp  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1625                 1630                 1635             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1640                 1645                 1650             


Ala 
    


<210> 12
<211> 1919
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Ser Glu Lys Gly Pro 
1               5                   10                  15      


Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Ser Trp Glu Phe 
            20                  25                  30          


Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu 
        35                  40                  45              


Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly 
    50                  55                  60                  


Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr 
65                  70                  75                  80  


Ser Glu Arg Arg Phe His Ser Ser Ile Ser Cys Ser Ile Thr Trp Phe 
                85                  90                  95      


Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe 
            100                 105                 110         


Leu Ser Gln His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu 
        115                 120                 125             


Phe Trp His Met Asp Gln Arg Asn Arg Gln Gly Leu Arg Asp Leu Val 
    130                 135                 140                 


Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His 
145                 150                 155                 160 


Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp 
                165                 170                 175     


Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His 
            180                 185                 190         


Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp 
        195                 200                 205             


Gln Asn His Leu Ala Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr 
    210                 215                 220                 


Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro 
225                 230                 235                 240 


Ser Val Thr Trp Arg Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser 
        275                 280                 285             


Ile Ile Asn Phe Gln Arg Arg Gly Leu Met Glu Thr Gln Ala Ser Asn 
    290                 295                 300                 


Gln Leu Ile Ser Ser His Leu Lys Gly Tyr Pro Ile Lys Asp Tyr Phe 
305                 310                 315                 320 


Val Gly Leu Ala Ile Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asn 
                325                 330                 335     


Lys Ala Tyr Glu Leu Leu Lys Phe Arg Ser His Lys Met Trp Gly Ser 
            340                 345                 350         


Arg Leu Phe Asp Glu Gly Glu Ser Ala Val Ala Arg Arg Gly Phe Arg 
        355                 360                 365             


Ser Met Arg Arg Arg Leu Glu Arg Arg Lys Leu Arg Leu Lys Leu Leu 
    370                 375                 380                 


Glu Glu Leu Phe Ala Asp Ala Met Ala Gln Val Asp Pro Thr Phe Phe 
385                 390                 395                 400 


Met Arg Leu Arg Glu Ser Lys Tyr His Tyr Glu Asp Lys Thr Thr Gly 
                405                 410                 415     


His Ser Ser Lys His Ile Leu Phe Ile Asp Lys Asn Tyr Asn Asp Gln 
            420                 425                 430         


Asp Tyr Phe Lys Glu Tyr Pro Thr Val Tyr His Leu Arg Ser Glu Leu 
        435                 440                 445             


Met Lys Ser Gly Thr Asp Asp Ile Arg Lys Leu Phe Leu Ala Val His 
    450                 455                 460                 


His Ile Leu Lys Tyr Arg Gly Asn Phe Leu Tyr Glu Gly Ala Thr Phe 
465                 470                 475                 480 


Asp Ser Asn Ala Ser Thr Leu Asp Asp Val Ile Lys Gln Ala Leu Glu 
                485                 490                 495     


Asn Ile Thr Phe Asn Cys Phe Asp Cys Asn Ser Ala Ile Ser Ser Ile 
            500                 505                 510         


Gly Gln Ile Leu Met Glu Ala Gly Lys Thr Lys Ser Asp Lys Ala Lys 
        515                 520                 525             


Ala Ile Glu His Leu Val Asp Thr Tyr Ile Ala Thr Asp Thr Val Asp 
    530                 535                 540                 


Thr Ser Ser Lys Thr Gln Lys Asp Gln Val Lys Glu Asp Lys Lys Arg 
545                 550                 555                 560 


Leu Lys Ala Phe Ala Asn Leu Val Leu Gly Leu Asn Ala Ser Leu Ile 
                565                 570                 575     


Asp Leu Phe Gly Ser Val Glu Glu Leu Glu Glu Asp Leu Lys Lys Leu 
            580                 585                 590         


Gln Ile Thr Gly Asp Thr Tyr Asp Asp Lys Arg Asp Glu Leu Ala Lys 
        595                 600                 605             


Ala Trp Ser Asp Glu Ile Tyr Ile Ile Asp Asp Cys Lys Ser Val Tyr 
    610                 615                 620                 


Asp Ala Ile Ile Leu Leu Ser Ile Lys Glu Pro Gly Leu Thr Ile Ser 
625                 630                 635                 640 


Glu Ser Lys Val Lys Ala Phe Asn Lys His Lys Asp Asp Leu Ala Ile 
                645                 650                 655     


Leu Lys Ser Leu Leu Lys Ser Asp Arg Ser Ile Tyr Asn Thr Met Phe 
            660                 665                 670         


Lys Val Asp Glu Lys Gly Leu His Asn Tyr Val His Tyr Ile Lys Gln 
        675                 680                 685             


Gly Arg Thr Glu Glu Thr Ser Cys Asn Arg Glu Asp Phe Tyr Lys Tyr 
    690                 695                 700                 


Thr Lys Lys Ile Val Glu Gly Leu Ser Asp Ser Lys Asp Lys Glu Tyr 
705                 710                 715                 720 


Ile Leu Ser Gln Ile Glu Leu Gln Ile Leu Leu Pro Leu Gln Arg Ile 
                725                 730                 735     


Lys Asp Asn Gly Val Ile Pro Tyr Gln Leu His Leu Glu Glu Leu Lys 
            740                 745                 750         


Ala Ile Leu Ala Lys Cys Gly Pro Lys Phe Pro Phe Leu Asn Glu Val 
        755                 760                 765             


Ala Asp Gly Phe Ser Val Ala Glu Lys Leu Ile Lys Met Leu Glu Phe 
    770                 775                 780                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Thr His His Asn Val Asp 
785                 790                 795                 800 


Asn Gly Gly Phe Ala Trp Ala Val Arg Lys Ala Ser Gly Arg Val Thr 
                805                 810                 815     


Pro Trp Asn Phe Asp Asp Lys Ile Asp Arg Glu Lys Ser Ala Ala Ala 
            820                 825                 830         


Phe Ile Lys Asn Leu Thr Asn Lys Cys Thr Tyr Leu Leu Gly Glu Asp 
        835                 840                 845             


Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn 
    850                 855                 860                 


Glu Leu Asn Asn Val Arg Ile Asp Gly Lys Pro Leu Glu Lys Val Val 
865                 870                 875                 880 


Lys Glu His Leu Ile Glu Ala Val Phe Lys Gln Asp His Lys Lys Met 
                885                 890                 895     


Thr Lys Asn Arg Ile Glu Gln Phe Leu Lys Asp Asn Gly Tyr Ile Ser 
            900                 905                 910         


Glu Thr His Lys His Glu Ile Thr Gly Leu Asp Gly Glu Ile Lys Asn 
        915                 920                 925             


Asp Leu Ala Ser Tyr Arg Asp Met Val Arg Ile Leu Gly Asp Gly Phe 
    930                 935                 940                 


Asp Arg Ser Met Ala Glu Glu Ile Ile Thr Asp Ile Thr Ile Phe Gly 
945                 950                 955                 960 


Glu Ser Lys Lys Met Leu Arg Glu Thr Leu Arg Lys Lys Phe Ala Ser 
                965                 970                 975     


Cys Leu Asp Asp Glu Ala Ile Lys Lys Leu Thr Lys Leu Arg Tyr Arg 
            980                 985                 990         


Asp Trp Gly Arg Leu Ser Gln Lys  Leu Leu Asn Gly Ile  Glu Gly Cys 
        995                 1000                 1005             


Asp Lys  Ala Gly Asp Gly Thr  Pro Glu Thr Ile Ile  Ile Leu Met 
    1010                 1015                 1020             


Arg Asn  Phe Ser Tyr Asn Leu  Met Glu Leu Leu Gly  Asp Lys Phe 
    1025                 1030                 1035             


Ser Phe  Met Glu Arg Ile Gln  Glu Ile Asn Ala Lys  Leu Thr Glu 
    1040                 1045                 1050             


Gly Gln  Ile Val Asn Pro His  Asp Ile Ile Asp Asp  Leu Ala Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Lys Arg Ala  Val Trp Gln Ala Leu  Arg Ile Val 
    1070                 1075                 1080             


Asp Glu  Val Ala His Ile Lys  Lys Ala Leu Pro Ala  Arg Ile Phe 
    1085                 1090                 1095             


Val Glu  Val Thr Arg Ser Asn  Lys Asn Glu Lys Lys  Lys Lys Asp 
    1100                 1105                 1110             


Ser Arg  Gln Lys Arg Leu Ser  Asp Leu Tyr Ala Ala  Ile Lys Lys 
    1115                 1120                 1125             


Asp Asp  Val Leu Leu Asn Gly  Leu Asn Asn Glu Ile  Phe Gly Glu 
    1130                 1135                 1140             


Leu Lys  Ser Ser Leu Ala Lys  Tyr Asp Asp Ala Ala  Leu Arg Ser 
    1145                 1150                 1155             


Lys Lys  Leu Tyr Leu Tyr Tyr  Thr Gln Met Gly Arg  Cys Ala Tyr 
    1160                 1165                 1170             


Thr Gly  Glu Ile Ile Glu Leu  Ser Leu Leu Asn Thr  Asp Asn Tyr 
    1175                 1180                 1185             


Asp Ile  Asp His Ile Tyr Pro  Arg Ser Leu Thr Lys  Asp Asp Ser 
    1190                 1195                 1200             


Phe Asp  Asn Leu Val Leu Cys  Lys Arg Thr Ala Asn  Ala Gln Lys 
    1205                 1210                 1215             


Ser Asp  Ala Tyr Pro Ile Ser  Glu Glu Ile Gln Lys  Thr Gln Lys 
    1220                 1225                 1230             


Pro Phe  Trp Thr Phe Leu Lys  Gln Gln Gly Leu Ile  Ser Glu Arg 
    1235                 1240                 1245             


Lys Tyr  Glu Arg Leu Thr Arg  Ile Thr Pro Leu Thr  Ala Asp Asp 
    1250                 1255                 1260             


Leu Ser  Gly Phe Ile Ala Arg  Gln Leu Val Glu Thr  Asn Gln Ser 
    1265                 1270                 1275             


Val Lys  Ala Ala Thr Thr Leu  Leu Arg Arg Leu Tyr  Pro Gly Val 
    1280                 1285                 1290             


Asp Val  Val Phe Val Lys Ala  Glu Asn Val Thr Asp  Phe Arg His 
    1295                 1300                 1305             


Asp Asn  Asn Phe Ile Lys Val  Arg Ser Leu Asn His  His His His 
    1310                 1315                 1320             


Ala Lys  Asp Ala Tyr Leu Asn  Ile Val Val Gly Asn  Val Tyr His 
    1325                 1330                 1335             


Glu Arg  Phe Thr Arg Asn Phe  Arg Ala Phe Phe Lys  Lys Asn Gly 
    1340                 1345                 1350             


Ala Asn  Arg Thr Tyr Asn Leu  Ala Lys Met Phe Asn  Tyr Asp Val 
    1355                 1360                 1365             


Asn Cys  Thr Asn Ala Lys Asp  Gly Lys Ala Trp Asp  Val Lys Thr 
    1370                 1375                 1380             


Ser Met  Asp Thr Val Lys Lys  Met Met Asp Ser Asn  Asp Val Arg 
    1385                 1390                 1395             


Val Thr  Lys Arg Leu Leu Glu  Gln Thr Gly Ala Leu  Ala Asp Ala 
    1400                 1405                 1410             


Thr Ile  Tyr Lys Ala Thr Val  Ala Gly Lys Ala Lys  Asp Gly Ala 
    1415                 1420                 1425             


Tyr Ile  Gly Met Lys Thr Lys  Ser Ser Val Phe Ala  Asp Val Ser 
    1430                 1435                 1440             


Lys Tyr  Gly Gly Met Thr Lys  Ile Lys Asn Ala Tyr  Ser Ile Ile 
    1445                 1450                 1455             


Val Gln  Tyr Thr Gly Lys Lys  Gly Glu Val Ile Lys  Glu Ile Val 
    1460                 1465                 1470             


Pro Leu  Pro Ile Tyr Leu Thr  Asn Arg Asn Thr Thr  Asp Gln Asp 
    1475                 1480                 1485             


Leu Ile  Asn Tyr Val Ala Ser  Ile Ile Pro Gln Ala  Lys Asp Ile 
    1490                 1495                 1500             


Ser Ile  Ile Tyr Gly Lys Leu  Cys Ile Asn Gln Leu  Val Lys Val 
    1505                 1510                 1515             


Asn Gly  Phe Tyr Tyr Tyr Leu  Gly Gly Lys Thr Asn  Ser Lys Phe 
    1520                 1525                 1530             


Cys Ile  Asp Asn Ala Ile Gln  Val Ile Val Ser Asn  Glu Trp Ile 
    1535                 1540                 1545             


Pro Tyr  Leu Lys Val Leu Glu  Lys Phe Asn Asn Met  Arg Lys Asp 
    1550                 1555                 1560             


Asn Lys  Asp Leu Lys Ala Asn  Val Val Ser Thr Arg  Ala Leu Asp 
    1565                 1570                 1575             


Asn Lys  His Thr Ile Glu Val  Arg Ile Val Glu Glu  Lys Asn Ile 
    1580                 1585                 1590             


Glu Phe  Phe Asp Tyr Leu Val  Ser Lys Leu Lys Met  Pro Ile Tyr 
    1595                 1600                 1605             


Gln Lys  Met Lys Gly Asn Lys  Ala Ala Glu Leu Ser  Glu Lys Gly 
    1610                 1615                 1620             


Tyr Gly  Leu Phe Lys Lys Met  Ser Leu Glu Glu Gln  Ser Ile His 
    1625                 1630                 1635             


Leu Ile  Glu Leu Leu Asn Leu  Leu Thr Asn Gln Lys  Thr Thr Phe 
    1640                 1645                 1650             


Glu Val  Lys Pro Leu Gly Ile  Thr Ala Ser Arg Ser  Thr Val Gly 
    1655                 1660                 1665             


Ser Lys  Ile Ser Asn Gln Asp  Glu Phe Lys Val Ile  Asn Glu Ser 
    1670                 1675                 1680             


Ile Thr  Gly Leu Tyr Ser Asn  Glu Val Thr Ile Val  Gly Lys Arg 
    1685                 1690                 1695             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys Gly 
    1700                 1705                 1710             


Ser Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1715                 1720                 1725             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1730                 1735                 1740             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1745                 1750                 1755             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1760                 1765                 1770             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1775                 1780                 1785             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1790                 1795                 1800             


Ile Lys  Met Leu Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr 
    1805                 1810                 1815             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1820                 1825                 1830             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1835                 1840                 1845             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1850                 1855                 1860             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1865                 1870                 1875             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1880                 1885                 1890             


Glu Asn  Lys Ile Lys Met Leu  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1895                 1900                 1905             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Tyr 
    1910                 1915                 


<210> 13
<211> 107
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
guuugagagu agugugaaaa cauuacgagu ucaaauacaa auuaauuuac aaugccuucg       60

ggcugcccga cguagggcac cuacucucaa uucuucggaa uugaguu                    107


<210> 14
<211> 1370
<212> PRT
<213> Ezakiella peruensis

<400> 14
Met Thr Lys Val Lys Asp Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe 
            20                  25                  30          


Asn Ser Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 
        35                  40                  45              


Ala Glu Glu Arg Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg 
    50                  55                  60                  


Lys Lys Glu Arg Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val 
65                  70                  75                  80  


Ala Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 
                85                  90                  95      


Tyr Met Glu Asp Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe 
            100                 105                 110         


Asn Asp Lys Asp Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr 
        115                 120                 125             


Ile His His Leu Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 
145                 150                 155                 160 


His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu 
                165                 170                 175     


Asn Ser Leu Asn Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu 
            180                 185                 190         


Asp Leu Glu Phe Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro 
        195                 200                 205             


Lys Leu Asn Lys Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly 
    210                 215                 220                 


Asp Thr Lys Phe Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser 
225                 230                 235                 240 


Gln Lys Leu Val Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser 
                245                 250                 255     


Ala Ile Lys Ser Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr 
            260                 265                 270         


Ser Asp Tyr Glu Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile 
        275                 280                 285             


Leu Lys Glu Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu 
    290                 295                 300                 


Ala Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val 
305                 310                 315                 320 


Lys Lys Tyr Asn Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu 
                325                 330                 335     


Val Arg Gln Tyr His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu 
            340                 345                 350         


Lys Val Asn Asp Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn 
        355                 360                 365             


Asn Lys Arg Val Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr 
    370                 375                 380                 


Lys Phe Ala Lys Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys 
385                 390                 395                 400 


Val Asn Gly Ser Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg 
                405                 410                 415     


Asp Met Glu Phe Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn 
            420                 425                 430         


Gly Val Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu 
        435                 440                 445             


Glu Asn Gln Ser Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr 
    450                 455                 460                 


Gly Ser Val Cys Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro 
465                 470                 475                 480 


Tyr Tyr Val Gly Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys 
                485                 490                 495     


Lys Gln Lys Asp Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val 
            500                 505                 510         


Asp Leu Asp Ser Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg 
        515                 520                 525             


Cys Thr Tyr Leu Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu 
    530                 535                 540                 


Tyr Asn Glu Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn 
545                 550                 555                 560 


Asp Leu Pro Ile Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu 
                565                 570                 575     


Phe Lys Thr Arg Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu 
            580                 585                 590         


Lys Lys Glu Phe Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp 
        595                 600                 605             


Gly Asp Phe Lys Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile 
    610                 615                 620                 


Val Gly Asp Lys Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu 
625                 630                 635                 640 


Ile Ile Lys Leu Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln 
                645                 650                 655     


Lys Lys Ile Lys Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile 
            660                 665                 670         


Lys Lys Met Ala Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys 
        675                 680                 685             


Lys Leu Leu Thr Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg 
    690                 695                 700                 


Gly Ser Ile Ile His Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu 
705                 710                 715                 720 


Leu Met Ser Ala Ser Phe Thr Phe Thr Glu Glu Ile Gln Lys Leu Asn 
                725                 730                 735     


Pro Val Asp Asp Arg Lys Leu Ser Tyr Glu Met Val Asp Glu Leu Tyr 
            740                 745                 750         


Leu Ser Pro Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Ile Val 
        755                 760                 765             


Asp Glu Ile Lys Asn Ile Met Gly Thr Asp Ser Lys Lys Ile Phe Ile 
    770                 775                 780                 


Glu Met Ala Arg Gly Lys Glu Glu Val Lys Ala Arg Lys Glu Ser Arg 
785                 790                 795                 800 


Lys Asn Gln Leu Leu Lys Phe Tyr Lys Asp Gly Lys Lys Ala Phe Ile 
                805                 810                 815     


Ser Glu Ile Gly Glu Glu Arg Tyr Ser Tyr Leu Leu Ser Glu Ile Glu 
            820                 825                 830         


Gly Glu Glu Glu Asn Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr 
        835                 840                 845             


Thr Gln Leu Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Ile Ser 
    850                 855                 860                 


Glu Leu Ser Ser Lys Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys 
865                 870                 875                 880 


Ser Lys Ile Tyr Asp Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys 
                885                 890                 895     


Asp Leu Asn Ser Lys Lys Gly Asn Ser Tyr Pro Ile Pro Asp Glu Ile 
            900                 905                 910         


Leu Asn Lys Asn Cys Tyr Ala Tyr Trp Lys Ile Leu Tyr Asp Lys Gly 
        915                 920                 925             


Leu Ile Gly Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Gly Phe 
    930                 935                 940                 


Thr Asp Asp Glu Leu Val Gln Phe Ile Ser Arg Gln Ile Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ala Thr Lys Glu Thr Ala Asn Leu Leu Lys Thr Ile Cys Lys 
                965                 970                 975     


Asn Ser Glu Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg 
            980                 985                 990         


Gln Glu Phe Asp Ile Val Lys Cys  Arg Ala Val Asn Asp  Leu His His 
        995                 1000                 1005             


Met His  Asp Ala Tyr Ile Asn  Ile Ile Val Gly Asn  Val Tyr Asn 
    1010                 1015                 1020             


Thr Lys  Phe Thr Lys Asp Pro  Met Asn Phe Val Lys  Lys Gln Glu 
    1025                 1030                 1035             


Lys Ala  Arg Ser Tyr Asn Leu  Glu Asn Met Phe Lys  Tyr Asp Val 
    1040                 1045                 1050             


Lys Arg  Gly Gly Tyr Thr Ala  Trp Ile Ala Asp Asp  Glu Lys Gly 
    1055                 1060                 1065             


Thr Val  Lys Asn Ala Ser Ile  Lys Arg Ile Arg Lys  Glu Leu Glu 
    1070                 1075                 1080             


Gly Thr  Asn Tyr Arg Phe Thr  Arg Met Asn Tyr Ile  Glu Ser Gly 
    1085                 1090                 1095             


Ala Leu  Phe Asn Ala Thr Leu  Gln Arg Lys Asn Lys  Gly Ser Arg 
    1100                 1105                 1110             


Pro Leu  Lys Asp Lys Gly Pro  Lys Ser Ser Ile Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Thr Asn Ile Asn Lys  Ala Cys Phe Ala Val  Leu Asp Ile 
    1130                 1135                 1140             


Lys Ser  Lys Asn Lys Ile Glu  Arg Lys Leu Met Pro  Val Glu Arg 
    1145                 1150                 1155             


Glu Ile  Tyr Ala Lys Gln Lys  Asn Asp Lys Lys Leu  Ser Asp Glu 
    1160                 1165                 1170             


Ile Phe  Ser Lys Tyr Leu Lys  Asp Arg Phe Gly Ile  Glu Asp Tyr 
    1175                 1180                 1185             


Arg Val  Val Tyr Pro Val Val  Lys Met Arg Thr Leu  Leu Lys Ile 
    1190                 1195                 1200             


Asp Gly  Ser Tyr Tyr Phe Ile  Thr Gly Gly Ser Asp  Lys Thr Leu 
    1205                 1210                 1215             


Glu Leu  Arg Ser Ala Leu Gln  Leu Ile Leu Pro Lys  Lys Asn Glu 
    1220                 1225                 1230             


Trp Ala  Ile Lys Gln Ile Asp  Lys Ser Ser Glu Asn  Asp Tyr Leu 
    1235                 1240                 1245             


Thr Ile  Glu Arg Ile Gln Asp  Leu Thr Glu Glu Leu  Val Tyr Asn 
    1250                 1255                 1260             


Thr Phe  Asp Ile Ile Val Asn  Lys Phe Lys Thr Ser  Val Phe Lys 
    1265                 1270                 1275             


Lys Ser  Phe Leu Asn Leu Phe  Gln Asp Asp Lys Ile  Glu Asn Ile 
    1280                 1285                 1290             


Asp Phe  Lys Phe Lys Ser Met  Asp Phe Lys Glu Lys  Cys Lys Thr 
    1295                 1300                 1305             


Leu Leu  Met Leu Val Lys Ala  Ile Arg Ala Ser Gly  Val Arg Gln 
    1310                 1315                 1320             


Asp Leu  Lys Ser Ile Asp Leu  Lys Ser Asp Tyr Gly  Arg Leu Ser 
    1325                 1330                 1335             


Ser Lys  Thr Asn Asn Ile Gly  Asn Tyr Gln Glu Phe  Lys Ile Ile 
    1340                 1345                 1350             


Asn Gln  Ser Ile Thr Gly Leu  Phe Glu Asn Glu Val  Asp Leu Leu 
    1355                 1360                 1365             


Lys Leu  
    1370 


<210> 15
<211> 1424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Pro Lys Lys Lys Arg Lys Val Gly Thr Lys Val Lys Asp Tyr Tyr 
1               5                   10                  15      


Ile Gly Leu Asp Ile Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asp 
            20                  25                  30          


Glu Ala Tyr Asn Val Leu Lys Phe Asn Ser Lys Lys Met Trp Gly Val 
        35                  40                  45              


Arg Leu Phe Asp Asp Ala Lys Thr Ala Glu Glu Arg Arg Gly Gln Arg 
    50                  55                  60                  


Gly Ala Arg Arg Arg Leu Asp Arg Lys Lys Glu Arg Leu Ser Leu Leu 
65                  70                  75                  80  


Gln Asp Phe Phe Ala Glu Glu Val Ala Lys Val Asp Pro Asn Phe Phe 
                85                  90                  95      


Leu Arg Leu Asp Asn Ser Asp Leu Tyr Met Glu Asp Lys Asp Gln Lys 
            100                 105                 110         


Leu Lys Ser Lys Tyr Thr Leu Phe Asn Asp Lys Asp Phe Lys Asp Lys 
        115                 120                 125             


Asn Phe His Lys Lys Tyr Pro Thr Ile His His Leu Leu Met Asp Leu 
    130                 135                 140                 


Ile Glu Asp Asp Ser Lys Lys Asp Ile Arg Leu Val Tyr Leu Ala Cys 
145                 150                 155                 160 


His Tyr Leu Leu Lys Asn Arg Gly His Phe Ile Phe Glu Gly Gln Lys 
                165                 170                 175     


Phe Asp Thr Lys Ser Ser Phe Glu Asn Ser Leu Asn Glu Leu Lys Val 
            180                 185                 190         


His Leu Asn Asp Glu Tyr Gly Leu Asp Leu Glu Phe Asp Asn Glu Asn 
        195                 200                 205             


Leu Ile Asn Ile Leu Thr Asp Pro Lys Leu Asn Lys Thr Ala Lys Lys 
    210                 215                 220                 


Lys Glu Leu Lys Ser Val Ile Gly Asp Thr Lys Phe Leu Lys Ala Val 
225                 230                 235                 240 


Ser Ala Ile Met Ile Gly Ser Ser Gln Lys Leu Val Asp Leu Phe Glu 
                245                 250                 255     


Asn Pro Glu Asp Phe Asp Asp Ser Ala Ile Lys Ser Val Asp Phe Ser 
            260                 265                 270         


Thr Thr Ser Phe Asp Asp Lys Tyr Ser Asp Tyr Glu Leu Ala Leu Gly 
        275                 280                 285             


Asp Lys Ile Ala Leu Val Asn Ile Leu Lys Glu Ile Tyr Asp Ser Ser 
    290                 295                 300                 


Ile Leu Glu Asn Leu Leu Lys Glu Ala Asp Lys Ser Lys Asp Gly Asn 
305                 310                 315                 320 


Lys Tyr Ile Ser Asn Ala Phe Val Lys Lys Tyr Asn Lys His Gly Gln 
                325                 330                 335     


Asp Leu Lys Glu Phe Lys Arg Leu Val Arg Gln Tyr His Lys Ser Ala 
            340                 345                 350         


Tyr Phe Asp Ile Phe Arg Ser Glu Lys Val Asn Asp Asn Tyr Val Ser 
        355                 360                 365             


Tyr Thr Lys Ser Ser Ile Ser Asn Asn Lys Arg Val Lys Ala Asn Lys 
    370                 375                 380                 


Phe Thr Asp Gln Glu Ala Phe Tyr Lys Phe Ala Lys Lys His Leu Glu 
385                 390                 395                 400 


Thr Ile Lys Tyr Lys Ile Asn Lys Val Asn Gly Ser Lys Ala Asp Leu 
                405                 410                 415     


Glu Leu Ile Asp Gly Met Leu Arg Asp Met Glu Phe Lys Asn Phe Met 
            420                 425                 430         


Pro Lys Ile Lys Ser Ser Asp Asn Gly Val Ile Pro Tyr Gln Leu Lys 
        435                 440                 445             


Leu Met Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Lys His His Glu 
    450                 455                 460                 


Phe Leu Asn Val Ser Asp Glu Tyr Gly Ser Val Cys Asp Lys Ile Ala 
465                 470                 475                 480 


Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Pro 
                485                 490                 495     


Asn Ser Lys Tyr Ala Trp Ile Lys Lys Gln Lys Asp Ser Glu Ile Thr 
            500                 505                 510         


Pro Trp Asn Phe Lys Asp Val Val Asp Leu Asp Ser Ser Arg Glu Glu 
        515                 520                 525             


Phe Ile Asp Ser Leu Ile Gly Arg Cys Thr Tyr Leu Lys Asp Glu Lys 
    530                 535                 540                 


Val Leu Pro Lys Ala Ser Leu Leu Tyr Asn Glu Tyr Met Val Leu Asn 
545                 550                 555                 560 


Glu Leu Asn Asn Leu Lys Leu Asn Asp Leu Pro Ile Thr Glu Glu Met 
                565                 570                 575     


Lys Lys Lys Ile Phe Asp Gln Leu Phe Lys Thr Arg Lys Lys Val Thr 
            580                 585                 590         


Leu Lys Ala Val Ala Asn Leu Leu Lys Lys Glu Phe Asn Ile Asn Gly 
        595                 600                 605             


Glu Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe Lys Gln Gly Leu Asn 
    610                 615                 620                 


Ser Tyr Asn Asp Phe Lys Ala Ile Val Gly Asp Lys Val Asp Ser Asp 
625                 630                 635                 640 


Asp Tyr Arg Asp Lys Ile Glu Glu Ile Ile Lys Leu Ile Val Leu Tyr 
                645                 650                 655     


Gly Asp Asp Lys Ser Tyr Leu Gln Lys Lys Ile Lys Ala Gly Tyr Gly 
            660                 665                 670         


Lys Tyr Phe Thr Asp Ser Glu Ile Lys Lys Met Ala Gly Leu Asn Tyr 
        675                 680                 685             


Lys Asp Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Glu Gly 
    690                 695                 700                 


Ala Asn Lys Ile Thr Gly Glu Arg Gly Ser Ile Ile His Phe Met Arg 
705                 710                 715                 720 


Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser Ala Ser Phe Thr Phe 
                725                 730                 735     


Thr Glu Glu Ile Gln Lys Leu Asn Pro Val Asp Asp Arg Lys Leu Ser 
            740                 745                 750         


Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro Ser Val Lys Arg Met 
        755                 760                 765             


Leu Trp Gln Ser Leu Arg Ile Val Asp Glu Ile Lys Asn Ile Met Gly 
    770                 775                 780                 


Thr Asp Ser Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu Glu 
785                 790                 795                 800 


Val Lys Ala Arg Lys Glu Ser Arg Lys Asn Gln Leu Leu Lys Phe Tyr 
                805                 810                 815     


Lys Asp Gly Lys Lys Ala Phe Ile Ser Glu Ile Gly Glu Glu Arg Tyr 
            820                 825                 830         


Ser Tyr Leu Leu Ser Glu Ile Glu Gly Glu Glu Glu Asn Lys Phe Arg 
        835                 840                 845             


Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg Cys Met Tyr 
    850                 855                 860                 


Ser Leu Glu Pro Ile Asp Ile Ser Glu Leu Ser Ser Lys Asn Ile Tyr 
865                 870                 875                 880 


Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp Asp Ser Ile 
                885                 890                 895     


Glu Asn Arg Val Leu Val Lys Lys Asp Leu Asn Ser Lys Lys Gly Asn 
            900                 905                 910         


Ser Tyr Pro Ile Pro Asp Glu Ile Leu Asn Lys Asn Cys Tyr Ala Tyr 
        915                 920                 925             


Trp Lys Ile Leu Tyr Asp Lys Gly Leu Ile Gly Gln Lys Lys Tyr Thr 
    930                 935                 940                 


Arg Leu Thr Arg Arg Thr Gly Phe Thr Asp Asp Glu Leu Val Gln Phe 
945                 950                 955                 960 


Ile Ser Arg Gln Ile Val Glu Thr Arg Gln Ala Thr Lys Glu Thr Ala 
                965                 970                 975     


Asn Leu Leu Lys Thr Ile Cys Lys Asn Ser Glu Ile Val Tyr Ser Lys 
            980                 985                 990         


Ala Glu Asn Ala Ser Arg Phe Arg  Gln Glu Phe Asp Ile  Val Lys Cys 
        995                 1000                 1005             


Arg Ala  Val Asn Asp Leu His  His Met His Asp Ala  Tyr Ile Asn 
    1010                 1015                 1020             


Ile Ile  Val Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Lys Asp Pro 
    1025                 1030                 1035             


Met Asn  Phe Val Lys Lys Gln  Glu Lys Ala Arg Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Glu Asn  Met Phe Lys Tyr Asp  Val Lys Arg Gly Gly  Tyr Thr Ala 
    1055                 1060                 1065             


Trp Ile  Ala Asp Asp Glu Lys  Gly Thr Val Lys Asn  Ala Ser Ile 
    1070                 1075                 1080             


Lys Arg  Ile Arg Lys Glu Leu  Glu Gly Thr Asn Tyr  Arg Phe Thr 
    1085                 1090                 1095             


Arg Met  Asn Tyr Ile Glu Ser  Gly Ala Leu Phe Asn  Ala Thr Leu 
    1100                 1105                 1110             


Gln Arg  Lys Asn Lys Gly Ser  Arg Pro Leu Lys Asp  Lys Gly Pro 
    1115                 1120                 1125             


Lys Ser  Ser Ile Glu Lys Tyr  Gly Gly Tyr Thr Asn  Ile Asn Lys 
    1130                 1135                 1140             


Ala Cys  Phe Ala Val Leu Asp  Ile Lys Ser Lys Asn  Lys Ile Glu 
    1145                 1150                 1155             


Arg Lys  Leu Met Pro Val Glu  Arg Glu Ile Tyr Ala  Lys Gln Lys 
    1160                 1165                 1170             


Asn Asp  Lys Lys Leu Ser Asp  Glu Ile Phe Ser Lys  Tyr Leu Lys 
    1175                 1180                 1185             


Asp Arg  Phe Gly Ile Glu Asp  Tyr Arg Val Val Tyr  Pro Val Val 
    1190                 1195                 1200             


Lys Met  Arg Thr Leu Leu Lys  Ile Asp Gly Ser Tyr  Tyr Phe Ile 
    1205                 1210                 1215             


Thr Gly  Gly Ser Asp Lys Thr  Leu Glu Leu Arg Ser  Ala Leu Gln 
    1220                 1225                 1230             


Leu Ile  Leu Pro Lys Lys Asn  Glu Trp Ala Ile Lys  Gln Ile Asp 
    1235                 1240                 1245             


Lys Ser  Ser Glu Asn Asp Tyr  Leu Thr Ile Glu Arg  Ile Gln Asp 
    1250                 1255                 1260             


Leu Thr  Glu Glu Leu Val Tyr  Asn Thr Phe Asp Ile  Ile Val Asn 
    1265                 1270                 1275             


Lys Phe  Lys Thr Ser Val Phe  Lys Lys Ser Phe Leu  Asn Leu Phe 
    1280                 1285                 1290             


Gln Asp  Asp Lys Ile Glu Asn  Ile Asp Phe Lys Phe  Lys Ser Met 
    1295                 1300                 1305             


Asp Phe  Lys Glu Lys Cys Lys  Thr Leu Leu Met Leu  Val Lys Ala 
    1310                 1315                 1320             


Ile Arg  Ala Ser Gly Val Arg  Gln Asp Leu Lys Ser  Ile Asp Leu 
    1325                 1330                 1335             


Lys Ser  Asp Tyr Gly Arg Leu  Ser Ser Lys Thr Asn  Asn Ile Gly 
    1340                 1345                 1350             


Asn Tyr  Gln Glu Phe Lys Ile  Ile Asn Gln Ser Ile  Thr Gly Leu 
    1355                 1360                 1365             


Phe Glu  Asn Glu Val Asp Leu  Leu Lys Leu Gly Lys  Arg Pro Ala 
    1370                 1375                 1380             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  Gly Ser Tyr 
    1385                 1390                 1395             


Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp 
    1400                 1405                 1410             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala 
    1415                 1420                 


<210> 16
<211> 1620
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Thr Lys Val 
        195                 200                 205             


Lys Asp Tyr Tyr Ile Gly Leu Ala Ile Gly Thr Ser Ser Val Gly Trp 
    210                 215                 220                 


Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe Asn Ser Lys Lys 
225                 230                 235                 240 


Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr Ala Glu Glu Arg 
                245                 250                 255     


Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg Lys Lys Glu Arg 
            260                 265                 270         


Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val Ala Lys Val Asp 
        275                 280                 285             


Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu Tyr Met Glu Asp 
    290                 295                 300                 


Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe Asn Asp Lys Asp 
305                 310                 315                 320 


Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr Ile His His Leu 
                325                 330                 335     


Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp Ile Arg Leu Val 
            340                 345                 350         


Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly His Phe Ile Phe 
        355                 360                 365             


Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu Asn Ser Leu Asn 
    370                 375                 380                 


Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu Asp Leu Glu Phe 
385                 390                 395                 400 


Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro Lys Leu Asn Lys 
                405                 410                 415     


Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly Asp Thr Lys Phe 
            420                 425                 430         


Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser Gln Lys Leu Val 
        435                 440                 445             


Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser Ala Ile Lys Ser 
    450                 455                 460                 


Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr Ser Asp Tyr Glu 
465                 470                 475                 480 


Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile Leu Lys Glu Ile 
                485                 490                 495     


Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu Ala Asp Lys Ser 
            500                 505                 510         


Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val Lys Lys Tyr Asn 
        515                 520                 525             


Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu Val Arg Gln Tyr 
    530                 535                 540                 


His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu Lys Val Asn Asp 
545                 550                 555                 560 


Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn Asn Lys Arg Val 
                565                 570                 575     


Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr Lys Phe Ala Lys 
            580                 585                 590         


Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys Val Asn Gly Ser 
        595                 600                 605             


Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg Asp Met Glu Phe 
    610                 615                 620                 


Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn Gly Val Ile Pro 
625                 630                 635                 640 


Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser 
                645                 650                 655     


Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr Gly Ser Val Cys 
            660                 665                 670         


Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr Val Gly 
        675                 680                 685             


Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys Lys Gln Lys Asp 
    690                 695                 700                 


Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val Asp Leu Asp Ser 
705                 710                 715                 720 


Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg Cys Thr Tyr Leu 
                725                 730                 735     


Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu Tyr Asn Glu Tyr 
            740                 745                 750         


Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Asp Leu Pro Ile 
        755                 760                 765             


Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu Phe Lys Thr Arg 
    770                 775                 780                 


Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu Lys Lys Glu Phe 
785                 790                 795                 800 


Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe Lys 
                805                 810                 815     


Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile Val Gly Asp Lys 
            820                 825                 830         


Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu Ile Ile Lys Leu 
        835                 840                 845             


Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln Lys Lys Ile Lys 
    850                 855                 860                 


Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile Lys Lys Met Ala 
865                 870                 875                 880 


Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr 
                885                 890                 895     


Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg Gly Ser Ile Ile 
            900                 905                 910         


His Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser Ala 
        915                 920                 925             


Ser Phe Thr Phe Thr Glu Glu Ile Gln Lys Leu Asn Pro Val Asp Asp 
    930                 935                 940                 


Arg Lys Leu Ser Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro Ser 
945                 950                 955                 960 


Val Lys Arg Met Leu Trp Gln Ser Leu Arg Ile Val Asp Glu Ile Lys 
                965                 970                 975     


Asn Ile Met Gly Thr Asp Ser Lys Lys Ile Phe Ile Glu Met Ala Arg 
            980                 985                 990         


Gly Lys Glu Glu Val Lys Ala Arg  Lys Glu Ser Arg Lys  Asn Gln Leu 
        995                 1000                 1005             


Leu Lys  Phe Tyr Lys Asp Gly  Lys Lys Ala Phe Ile  Ser Glu Ile 
    1010                 1015                 1020             


Gly Glu  Glu Arg Tyr Ser Tyr  Leu Leu Ser Glu Ile  Glu Gly Glu 
    1025                 1030                 1035             


Glu Glu  Asn Lys Phe Arg Trp  Asp Asn Leu Tyr Leu  Tyr Tyr Thr 
    1040                 1045                 1050             


Gln Leu  Gly Arg Cys Met Tyr  Ser Leu Glu Pro Ile  Asp Ile Ser 
    1055                 1060                 1065             


Glu Leu  Ser Ser Lys Asn Ile  Tyr Asp Gln Asp His  Ile Tyr Pro 
    1070                 1075                 1080             


Lys Ser  Lys Ile Tyr Asp Asp  Ser Ile Glu Asn Arg  Val Leu Val 
    1085                 1090                 1095             


Lys Lys  Asp Leu Asn Ser Lys  Lys Gly Asn Ser Tyr  Pro Ile Pro 
    1100                 1105                 1110             


Asp Glu  Ile Leu Asn Lys Asn  Cys Tyr Ala Tyr Trp  Lys Ile Leu 
    1115                 1120                 1125             


Tyr Asp  Lys Gly Leu Ile Gly  Gln Lys Lys Tyr Thr  Arg Leu Thr 
    1130                 1135                 1140             


Arg Arg  Thr Gly Phe Thr Asp  Asp Glu Leu Val Gln  Phe Ile Ser 
    1145                 1150                 1155             


Arg Gln  Ile Val Glu Thr Arg  Gln Ala Thr Lys Glu  Thr Ala Asn 
    1160                 1165                 1170             


Leu Leu  Lys Thr Ile Cys Lys  Asn Ser Glu Ile Val  Tyr Ser Lys 
    1175                 1180                 1185             


Ala Glu  Asn Ala Ser Arg Phe  Arg Gln Glu Phe Asp  Ile Val Lys 
    1190                 1195                 1200             


Cys Arg  Ala Val Asn Asp Leu  His His Met His Asp  Ala Tyr Ile 
    1205                 1210                 1215             


Asn Ile  Ile Val Gly Asn Val  Tyr Asn Thr Lys Phe  Thr Lys Asp 
    1220                 1225                 1230             


Pro Met  Asn Phe Val Lys Lys  Gln Glu Lys Ala Arg  Ser Tyr Asn 
    1235                 1240                 1245             


Leu Glu  Asn Met Phe Lys Tyr  Asp Val Lys Arg Gly  Gly Tyr Thr 
    1250                 1255                 1260             


Ala Trp  Ile Ala Asp Asp Glu  Lys Gly Thr Val Lys  Asn Ala Ser 
    1265                 1270                 1275             


Ile Lys  Arg Ile Arg Lys Glu  Leu Glu Gly Thr Asn  Tyr Arg Phe 
    1280                 1285                 1290             


Thr Arg  Met Asn Tyr Ile Glu  Ser Gly Ala Leu Phe  Asn Ala Thr 
    1295                 1300                 1305             


Leu Gln  Arg Lys Asn Lys Gly  Ser Arg Pro Leu Lys  Asp Lys Gly 
    1310                 1315                 1320             


Pro Lys  Ser Ser Ile Glu Lys  Tyr Gly Gly Tyr Thr  Asn Ile Asn 
    1325                 1330                 1335             


Lys Ala  Cys Phe Ala Val Leu  Asp Ile Lys Ser Lys  Asn Lys Ile 
    1340                 1345                 1350             


Glu Arg  Lys Leu Met Pro Val  Glu Arg Glu Ile Tyr  Ala Lys Gln 
    1355                 1360                 1365             


Lys Asn  Asp Lys Lys Leu Ser  Asp Glu Ile Phe Ser  Lys Tyr Leu 
    1370                 1375                 1380             


Lys Asp  Arg Phe Gly Ile Glu  Asp Tyr Arg Val Val  Tyr Pro Val 
    1385                 1390                 1395             


Val Lys  Met Arg Thr Leu Leu  Lys Ile Asp Gly Ser  Tyr Tyr Phe 
    1400                 1405                 1410             


Ile Thr  Gly Gly Ser Asp Lys  Thr Leu Glu Leu Arg  Ser Ala Leu 
    1415                 1420                 1425             


Gln Leu  Ile Leu Pro Lys Lys  Asn Glu Trp Ala Ile  Lys Gln Ile 
    1430                 1435                 1440             


Asp Lys  Ser Ser Glu Asn Asp  Tyr Leu Thr Ile Glu  Arg Ile Gln 
    1445                 1450                 1455             


Asp Leu  Thr Glu Glu Leu Val  Tyr Asn Thr Phe Asp  Ile Ile Val 
    1460                 1465                 1470             


Asn Lys  Phe Lys Thr Ser Val  Phe Lys Lys Ser Phe  Leu Asn Leu 
    1475                 1480                 1485             


Phe Gln  Asp Asp Lys Ile Glu  Asn Ile Asp Phe Lys  Phe Lys Ser 
    1490                 1495                 1500             


Met Asp  Phe Lys Glu Lys Cys  Lys Thr Leu Leu Met  Leu Val Lys 
    1505                 1510                 1515             


Ala Ile  Arg Ala Ser Gly Val  Arg Gln Asp Leu Lys  Ser Ile Asp 
    1520                 1525                 1530             


Leu Lys  Ser Asp Tyr Gly Arg  Leu Ser Ser Lys Thr  Asn Asn Ile 
    1535                 1540                 1545             


Gly Asn  Tyr Gln Glu Phe Lys  Ile Ile Asn Gln Ser  Ile Thr Gly 
    1550                 1555                 1560             


Leu Phe  Glu Asn Glu Val Asp  Leu Leu Lys Leu Gly  Lys Arg Pro 
    1565                 1570                 1575             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Gly Ser 
    1580                 1585                 1590             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Tyr Pro Tyr  Asp Val Pro 
    1595                 1600                 1605             


Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  
    1610                 1615                 1620 


<210> 17
<211> 1615
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Pro Lys Lys Lys Arg Lys Val Thr Lys Val Lys Asp Tyr Tyr Ile 
1               5                   10                  15      


Gly Leu Ala Ile Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asp Glu 
            20                  25                  30          


Ala Tyr Asn Val Leu Lys Phe Asn Ser Lys Lys Met Trp Gly Val Arg 
        35                  40                  45              


Leu Phe Asp Asp Ala Lys Thr Ala Glu Glu Arg Arg Gly Gln Arg Gly 
    50                  55                  60                  


Ala Arg Arg Arg Leu Asp Arg Lys Lys Glu Arg Leu Ser Leu Leu Gln 
65                  70                  75                  80  


Asp Phe Phe Ala Glu Glu Val Ala Lys Val Asp Pro Asn Phe Phe Leu 
                85                  90                  95      


Arg Leu Asp Asn Ser Asp Leu Tyr Met Glu Asp Lys Asp Gln Lys Leu 
            100                 105                 110         


Lys Ser Lys Tyr Thr Leu Phe Asn Asp Lys Asp Phe Lys Asp Lys Asn 
        115                 120                 125             


Phe His Lys Lys Tyr Pro Thr Ile His His Leu Leu Met Asp Leu Ile 
    130                 135                 140                 


Glu Asp Asp Ser Lys Lys Asp Ile Arg Leu Val Tyr Leu Ala Cys His 
145                 150                 155                 160 


Tyr Leu Leu Lys Asn Arg Gly His Phe Ile Phe Glu Gly Gln Lys Phe 
                165                 170                 175     


Asp Thr Lys Ser Ser Phe Glu Asn Ser Leu Asn Glu Leu Lys Val His 
            180                 185                 190         


Leu Asn Asp Glu Tyr Gly Leu Asp Leu Glu Phe Asp Asn Glu Asn Leu 
        195                 200                 205             


Ile Asn Ile Leu Thr Asp Pro Lys Leu Asn Lys Thr Ala Lys Lys Lys 
    210                 215                 220                 


Glu Leu Lys Ser Val Ile Gly Asp Thr Lys Phe Leu Lys Ala Val Ser 
225                 230                 235                 240 


Ala Ile Met Ile Gly Ser Ser Gln Lys Leu Val Asp Leu Phe Glu Asn 
                245                 250                 255     


Pro Glu Asp Phe Asp Asp Ser Ala Ile Lys Ser Val Asp Phe Ser Thr 
            260                 265                 270         


Thr Ser Phe Asp Asp Lys Tyr Ser Asp Tyr Glu Leu Ala Leu Gly Asp 
        275                 280                 285             


Lys Ile Ala Leu Val Asn Ile Leu Lys Glu Ile Tyr Asp Ser Ser Ile 
    290                 295                 300                 


Leu Glu Asn Leu Leu Lys Glu Ala Asp Lys Ser Lys Asp Gly Asn Lys 
305                 310                 315                 320 


Tyr Ile Ser Asn Ala Phe Val Lys Lys Tyr Asn Lys His Gly Gln Asp 
                325                 330                 335     


Leu Lys Glu Phe Lys Arg Leu Val Arg Gln Tyr His Lys Ser Ala Tyr 
            340                 345                 350         


Phe Asp Ile Phe Arg Ser Glu Lys Val Asn Asp Asn Tyr Val Ser Tyr 
        355                 360                 365             


Thr Lys Ser Ser Ile Ser Asn Asn Lys Arg Val Lys Ala Asn Lys Phe 
    370                 375                 380                 


Thr Asp Gln Glu Ala Phe Tyr Lys Phe Ala Lys Lys His Leu Glu Thr 
385                 390                 395                 400 


Ile Lys Tyr Lys Ile Asn Lys Val Asn Gly Ser Lys Ala Asp Leu Glu 
                405                 410                 415     


Leu Ile Asp Gly Met Leu Arg Asp Met Glu Phe Lys Asn Phe Met Pro 
            420                 425                 430         


Lys Ile Lys Ser Ser Asp Asn Gly Val Ile Pro Tyr Gln Leu Lys Leu 
        435                 440                 445             


Met Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Lys His His Glu Phe 
    450                 455                 460                 


Leu Asn Val Ser Asp Glu Tyr Gly Ser Val Cys Asp Lys Ile Ala Ser 
465                 470                 475                 480 


Ile Met Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Pro Asn 
                485                 490                 495     


Ser Lys Tyr Ala Trp Ile Lys Lys Gln Lys Asp Ser Glu Ile Thr Pro 
            500                 505                 510         


Trp Asn Phe Lys Asp Val Val Asp Leu Asp Ser Ser Arg Glu Glu Phe 
        515                 520                 525             


Ile Asp Ser Leu Ile Gly Arg Cys Thr Tyr Leu Lys Asp Glu Lys Val 
    530                 535                 540                 


Leu Pro Lys Ala Ser Leu Leu Tyr Asn Glu Tyr Met Val Leu Asn Glu 
545                 550                 555                 560 


Leu Asn Asn Leu Lys Leu Asn Asp Leu Pro Ile Thr Glu Glu Met Lys 
                565                 570                 575     


Lys Lys Ile Phe Asp Gln Leu Phe Lys Thr Arg Lys Lys Val Thr Leu 
            580                 585                 590         


Lys Ala Val Ala Asn Leu Leu Lys Lys Glu Phe Asn Ile Asn Gly Glu 
        595                 600                 605             


Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe Lys Gln Gly Leu Asn Ser 
    610                 615                 620                 


Tyr Asn Asp Phe Lys Ala Ile Val Gly Asp Lys Val Asp Ser Asp Asp 
625                 630                 635                 640 


Tyr Arg Asp Lys Ile Glu Glu Ile Ile Lys Leu Ile Val Leu Tyr Gly 
                645                 650                 655     


Asp Asp Lys Ser Tyr Leu Gln Lys Lys Ile Lys Ala Gly Tyr Gly Lys 
            660                 665                 670         


Tyr Phe Thr Asp Ser Glu Ile Lys Lys Met Ala Gly Leu Asn Tyr Lys 
        675                 680                 685             


Asp Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Glu Gly Ala 
    690                 695                 700                 


Asn Lys Ile Thr Gly Glu Arg Gly Ser Ile Ile His Phe Met Arg Glu 
705                 710                 715                 720 


Tyr Asn Leu Asn Leu Met Glu Leu Met Ser Ala Ser Phe Thr Phe Thr 
                725                 730                 735     


Glu Glu Ile Gln Lys Leu Asn Pro Val Asp Asp Arg Lys Leu Ser Tyr 
            740                 745                 750         


Glu Met Val Asp Glu Leu Tyr Leu Ser Pro Ser Val Lys Arg Met Leu 
        755                 760                 765             


Trp Gln Ser Leu Arg Ile Val Asp Glu Ile Lys Asn Ile Met Gly Thr 
    770                 775                 780                 


Asp Ser Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu Glu Val 
785                 790                 795                 800 


Lys Ala Arg Lys Glu Ser Arg Lys Asn Gln Leu Leu Lys Phe Tyr Lys 
                805                 810                 815     


Asp Gly Lys Lys Ala Phe Ile Ser Glu Ile Gly Glu Glu Arg Tyr Ser 
            820                 825                 830         


Tyr Leu Leu Ser Glu Ile Glu Gly Glu Glu Glu Asn Lys Phe Arg Trp 
        835                 840                 845             


Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg Cys Met Tyr Ser 
    850                 855                 860                 


Leu Glu Pro Ile Asp Ile Ser Glu Leu Ser Ser Lys Asn Ile Tyr Asp 
865                 870                 875                 880 


Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp Asp Ser Ile Glu 
                885                 890                 895     


Asn Arg Val Leu Val Lys Lys Asp Leu Asn Ser Lys Lys Gly Asn Ser 
            900                 905                 910         


Tyr Pro Ile Pro Asp Glu Ile Leu Asn Lys Asn Cys Tyr Ala Tyr Trp 
        915                 920                 925             


Lys Ile Leu Tyr Asp Lys Gly Leu Ile Gly Gln Lys Lys Tyr Thr Arg 
    930                 935                 940                 


Leu Thr Arg Arg Thr Gly Phe Thr Asp Asp Glu Leu Val Gln Phe Ile 
945                 950                 955                 960 


Ser Arg Gln Ile Val Glu Thr Arg Gln Ala Thr Lys Glu Thr Ala Asn 
                965                 970                 975     


Leu Leu Lys Thr Ile Cys Lys Asn Ser Glu Ile Val Tyr Ser Lys Ala 
            980                 985                 990         


Glu Asn Ala Ser Arg Phe Arg Gln  Glu Phe Asp Ile Val  Lys Cys Arg 
        995                 1000                 1005             


Ala Val  Asn Asp Leu His His  Met His Asp Ala Tyr  Ile Asn Ile 
    1010                 1015                 1020             


Ile Val  Gly Asn Val Tyr Asn  Thr Lys Phe Thr Lys  Asp Pro Met 
    1025                 1030                 1035             


Asn Phe  Val Lys Lys Gln Glu  Lys Ala Arg Ser Tyr  Asn Leu Glu 
    1040                 1045                 1050             


Asn Met  Phe Lys Tyr Asp Val  Lys Arg Gly Gly Tyr  Thr Ala Trp 
    1055                 1060                 1065             


Ile Ala  Asp Asp Glu Lys Gly  Thr Val Lys Asn Ala  Ser Ile Lys 
    1070                 1075                 1080             


Arg Ile  Arg Lys Glu Leu Glu  Gly Thr Asn Tyr Arg  Phe Thr Arg 
    1085                 1090                 1095             


Met Asn  Tyr Ile Glu Ser Gly  Ala Leu Phe Asn Ala  Thr Leu Gln 
    1100                 1105                 1110             


Arg Lys  Asn Lys Gly Ser Arg  Pro Leu Lys Asp Lys  Gly Pro Lys 
    1115                 1120                 1125             


Ser Ser  Ile Glu Lys Tyr Gly  Gly Tyr Thr Asn Ile  Asn Lys Ala 
    1130                 1135                 1140             


Cys Phe  Ala Val Leu Asp Ile  Lys Ser Lys Asn Lys  Ile Glu Arg 
    1145                 1150                 1155             


Lys Leu  Met Pro Val Glu Arg  Glu Ile Tyr Ala Lys  Gln Lys Asn 
    1160                 1165                 1170             


Asp Lys  Lys Leu Ser Asp Glu  Ile Phe Ser Lys Tyr  Leu Lys Asp 
    1175                 1180                 1185             


Arg Phe  Gly Ile Glu Asp Tyr  Arg Val Val Tyr Pro  Val Val Lys 
    1190                 1195                 1200             


Met Arg  Thr Leu Leu Lys Ile  Asp Gly Ser Tyr Tyr  Phe Ile Thr 
    1205                 1210                 1215             


Gly Gly  Ser Asp Lys Thr Leu  Glu Leu Arg Ser Ala  Leu Gln Leu 
    1220                 1225                 1230             


Ile Leu  Pro Lys Lys Asn Glu  Trp Ala Ile Lys Gln  Ile Asp Lys 
    1235                 1240                 1245             


Ser Ser  Glu Asn Asp Tyr Leu  Thr Ile Glu Arg Ile  Gln Asp Leu 
    1250                 1255                 1260             


Thr Glu  Glu Leu Val Tyr Asn  Thr Phe Asp Ile Ile  Val Asn Lys 
    1265                 1270                 1275             


Phe Lys  Thr Ser Val Phe Lys  Lys Ser Phe Leu Asn  Leu Phe Gln 
    1280                 1285                 1290             


Asp Asp  Lys Ile Glu Asn Ile  Asp Phe Lys Phe Lys  Ser Met Asp 
    1295                 1300                 1305             


Phe Lys  Glu Lys Cys Lys Thr  Leu Leu Met Leu Val  Lys Ala Ile 
    1310                 1315                 1320             


Arg Ala  Ser Gly Val Arg Gln  Asp Leu Lys Ser Ile  Asp Leu Lys 
    1325                 1330                 1335             


Ser Asp  Tyr Gly Arg Leu Ser  Ser Lys Thr Asn Asn  Ile Gly Asn 
    1340                 1345                 1350             


Tyr Gln  Glu Phe Lys Ile Ile  Asn Gln Ser Ile Thr  Gly Leu Phe 
    1355                 1360                 1365             


Glu Asn  Glu Val Asp Leu Leu  Lys Leu Lys Arg Pro  Ala Ala Thr 
    1370                 1375                 1380             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Ser Gly  Ser Glu Thr 
    1385                 1390                 1395             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Ser  Gly Ser Glu 
    1400                 1405                 1410             


Val Glu  Phe Ser His Glu Tyr  Trp Met Arg His Ala  Leu Thr Leu 
    1415                 1420                 1425             


Ala Lys  Arg Ala Arg Asp Glu  Arg Glu Val Pro Val  Gly Ala Val 
    1430                 1435                 1440             


Leu Val  Leu Asn Asn Arg Val  Ile Gly Glu Gly Trp  Asn Arg Ala 
    1445                 1450                 1455             


Ile Gly  Leu His Asp Pro Thr  Ala His Ala Glu Ile  Met Ala Leu 
    1460                 1465                 1470             


Arg Gln  Gly Gly Leu Val Met  Gln Asn Tyr Arg Leu  Tyr Asp Ala 
    1475                 1480                 1485             


Thr Leu  Tyr Val Thr Phe Glu  Pro Cys Val Met Cys  Ala Gly Ala 
    1490                 1495                 1500             


Met Ile  His Ser Arg Ile Gly  Arg Val Val Phe Gly  Val Arg Asn 
    1505                 1510                 1515             


Ala Lys  Thr Gly Ala Ala Gly  Ser Leu Met Asp Val  Leu His His 
    1520                 1525                 1530             


Pro Gly  Met Asn His Arg Val  Glu Ile Thr Glu Gly  Ile Leu Ala 
    1535                 1540                 1545             


Asp Glu  Cys Ala Ala Leu Leu  Cys Arg Phe Phe Arg  Met Pro Arg 
    1550                 1555                 1560             


Arg Val  Phe Asn Ala Gln Lys  Lys Ala Gln Ser Ser  Thr Asp Pro 
    1565                 1570                 1575             


Ala Ala  Lys Arg Val Lys Leu  Asp Gly Ser Tyr Pro  Tyr Asp Val 
    1580                 1585                 1590             


Pro Asp  Tyr Ala Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1595                 1600                 1605             


Tyr Asp  Val Pro Asp Tyr Ala  
    1610                 1615 


<210> 18
<211> 1880
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Ser Glu Lys Gly Pro 
1               5                   10                  15      


Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Ser Trp Glu Phe 
            20                  25                  30          


Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu 
        35                  40                  45              


Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly 
    50                  55                  60                  


Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr 
65                  70                  75                  80  


Ser Glu Arg Arg Phe His Ser Ser Ile Ser Cys Ser Ile Thr Trp Phe 
                85                  90                  95      


Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe 
            100                 105                 110         


Leu Ser Gln His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu 
        115                 120                 125             


Phe Trp His Met Asp Gln Arg Asn Arg Gln Gly Leu Arg Asp Leu Val 
    130                 135                 140                 


Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His 
145                 150                 155                 160 


Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp 
                165                 170                 175     


Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His 
            180                 185                 190         


Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp 
        195                 200                 205             


Gln Asn His Leu Ala Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr 
    210                 215                 220                 


Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro 
225                 230                 235                 240 


Ser Val Thr Trp Arg Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Thr 
        275                 280                 285             


Lys Val Lys Asp Tyr Tyr Ile Gly Leu Ala Ile Gly Thr Ser Ser Val 
    290                 295                 300                 


Gly Trp Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe Asn Ser 
305                 310                 315                 320 


Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr Ala Glu 
                325                 330                 335     


Glu Arg Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg Lys Lys 
            340                 345                 350         


Glu Arg Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val Ala Lys 
        355                 360                 365             


Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu Tyr Met 
    370                 375                 380                 


Glu Asp Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe Asn Asp 
385                 390                 395                 400 


Lys Asp Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr Ile His 
                405                 410                 415     


His Leu Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp Ile Arg 
            420                 425                 430         


Leu Val Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly His Phe 
        435                 440                 445             


Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu Asn Ser 
    450                 455                 460                 


Leu Asn Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu Asp Leu 
465                 470                 475                 480 


Glu Phe Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro Lys Leu 
                485                 490                 495     


Asn Lys Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly Asp Thr 
            500                 505                 510         


Lys Phe Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser Gln Lys 
        515                 520                 525             


Leu Val Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser Ala Ile 
    530                 535                 540                 


Lys Ser Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr Ser Asp 
545                 550                 555                 560 


Tyr Glu Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile Leu Lys 
                565                 570                 575     


Glu Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu Ala Asp 
            580                 585                 590         


Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val Lys Lys 
        595                 600                 605             


Tyr Asn Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu Val Arg 
    610                 615                 620                 


Gln Tyr His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu Lys Val 
625                 630                 635                 640 


Asn Asp Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn Asn Lys 
                645                 650                 655     


Arg Val Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr Lys Phe 
            660                 665                 670         


Ala Lys Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys Val Asn 
        675                 680                 685             


Gly Ser Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg Asp Met 
    690                 695                 700                 


Glu Phe Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn Gly Val 
705                 710                 715                 720 


Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu Glu Asn 
                725                 730                 735     


Gln Ser Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr Gly Ser 
            740                 745                 750         


Val Cys Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr 
        755                 760                 765             


Val Gly Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys Lys Gln 
    770                 775                 780                 


Lys Asp Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val Asp Leu 
785                 790                 795                 800 


Asp Ser Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg Cys Thr 
                805                 810                 815     


Tyr Leu Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu Tyr Asn 
            820                 825                 830         


Glu Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Asp Leu 
        835                 840                 845             


Pro Ile Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu Phe Lys 
    850                 855                 860                 


Thr Arg Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu Lys Lys 
865                 870                 875                 880 


Glu Phe Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp Gly Asp 
                885                 890                 895     


Phe Lys Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile Val Gly 
            900                 905                 910         


Asp Lys Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu Ile Ile 
        915                 920                 925             


Lys Leu Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln Lys Lys 
    930                 935                 940                 


Ile Lys Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile Lys Lys 
945                 950                 955                 960 


Met Ala Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Lys Leu 
                965                 970                 975     


Leu Thr Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg Gly Ser 
            980                 985                 990         


Ile Ile His Phe Met Arg Glu Tyr  Asn Leu Asn Leu Met  Glu Leu Met 
        995                 1000                 1005             


Ser Ala  Ser Phe Thr Phe Thr  Glu Glu Ile Gln Lys  Leu Asn Pro 
    1010                 1015                 1020             


Val Asp  Asp Arg Lys Leu Ser  Tyr Glu Met Val Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Leu Ser  Pro Ser Val Lys Arg  Met Leu Trp Gln Ser  Leu Arg Ile 
    1040                 1045                 1050             


Val Asp  Glu Ile Lys Asn Ile  Met Gly Thr Asp Ser  Lys Lys Ile 
    1055                 1060                 1065             


Phe Ile  Glu Met Ala Arg Gly  Lys Glu Glu Val Lys  Ala Arg Lys 
    1070                 1075                 1080             


Glu Ser  Arg Lys Asn Gln Leu  Leu Lys Phe Tyr Lys  Asp Gly Lys 
    1085                 1090                 1095             


Lys Ala  Phe Ile Ser Glu Ile  Gly Glu Glu Arg Tyr  Ser Tyr Leu 
    1100                 1105                 1110             


Leu Ser  Glu Ile Glu Gly Glu  Glu Glu Asn Lys Phe  Arg Trp Asp 
    1115                 1120                 1125             


Asn Leu  Tyr Leu Tyr Tyr Thr  Gln Leu Gly Arg Cys  Met Tyr Ser 
    1130                 1135                 1140             


Leu Glu  Pro Ile Asp Ile Ser  Glu Leu Ser Ser Lys  Asn Ile Tyr 
    1145                 1150                 1155             


Asp Gln  Asp His Ile Tyr Pro  Lys Ser Lys Ile Tyr  Asp Asp Ser 
    1160                 1165                 1170             


Ile Glu  Asn Arg Val Leu Val  Lys Lys Asp Leu Asn  Ser Lys Lys 
    1175                 1180                 1185             


Gly Asn  Ser Tyr Pro Ile Pro  Asp Glu Ile Leu Asn  Lys Asn Cys 
    1190                 1195                 1200             


Tyr Ala  Tyr Trp Lys Ile Leu  Tyr Asp Lys Gly Leu  Ile Gly Gln 
    1205                 1210                 1215             


Lys Lys  Tyr Thr Arg Leu Thr  Arg Arg Thr Gly Phe  Thr Asp Asp 
    1220                 1225                 1230             


Glu Leu  Val Gln Phe Ile Ser  Arg Gln Ile Val Glu  Thr Arg Gln 
    1235                 1240                 1245             


Ala Thr  Lys Glu Thr Ala Asn  Leu Leu Lys Thr Ile  Cys Lys Asn 
    1250                 1255                 1260             


Ser Glu  Ile Val Tyr Ser Lys  Ala Glu Asn Ala Ser  Arg Phe Arg 
    1265                 1270                 1275             


Gln Glu  Phe Asp Ile Val Lys  Cys Arg Ala Val Asn  Asp Leu His 
    1280                 1285                 1290             


His Met  His Asp Ala Tyr Ile  Asn Ile Ile Val Gly  Asn Val Tyr 
    1295                 1300                 1305             


Asn Thr  Lys Phe Thr Lys Asp  Pro Met Asn Phe Val  Lys Lys Gln 
    1310                 1315                 1320             


Glu Lys  Ala Arg Ser Tyr Asn  Leu Glu Asn Met Phe  Lys Tyr Asp 
    1325                 1330                 1335             


Val Lys  Arg Gly Gly Tyr Thr  Ala Trp Ile Ala Asp  Asp Glu Lys 
    1340                 1345                 1350             


Gly Thr  Val Lys Asn Ala Ser  Ile Lys Arg Ile Arg  Lys Glu Leu 
    1355                 1360                 1365             


Glu Gly  Thr Asn Tyr Arg Phe  Thr Arg Met Asn Tyr  Ile Glu Ser 
    1370                 1375                 1380             


Gly Ala  Leu Phe Asn Ala Thr  Leu Gln Arg Lys Asn  Lys Gly Ser 
    1385                 1390                 1395             


Arg Pro  Leu Lys Asp Lys Gly  Pro Lys Ser Ser Ile  Glu Lys Tyr 
    1400                 1405                 1410             


Gly Gly  Tyr Thr Asn Ile Asn  Lys Ala Cys Phe Ala  Val Leu Asp 
    1415                 1420                 1425             


Ile Lys  Ser Lys Asn Lys Ile  Glu Arg Lys Leu Met  Pro Val Glu 
    1430                 1435                 1440             


Arg Glu  Ile Tyr Ala Lys Gln  Lys Asn Asp Lys Lys  Leu Ser Asp 
    1445                 1450                 1455             


Glu Ile  Phe Ser Lys Tyr Leu  Lys Asp Arg Phe Gly  Ile Glu Asp 
    1460                 1465                 1470             


Tyr Arg  Val Val Tyr Pro Val  Val Lys Met Arg Thr  Leu Leu Lys 
    1475                 1480                 1485             


Ile Asp  Gly Ser Tyr Tyr Phe  Ile Thr Gly Gly Ser  Asp Lys Thr 
    1490                 1495                 1500             


Leu Glu  Leu Arg Ser Ala Leu  Gln Leu Ile Leu Pro  Lys Lys Asn 
    1505                 1510                 1515             


Glu Trp  Ala Ile Lys Gln Ile  Asp Lys Ser Ser Glu  Asn Asp Tyr 
    1520                 1525                 1530             


Leu Thr  Ile Glu Arg Ile Gln  Asp Leu Thr Glu Glu  Leu Val Tyr 
    1535                 1540                 1545             


Asn Thr  Phe Asp Ile Ile Val  Asn Lys Phe Lys Thr  Ser Val Phe 
    1550                 1555                 1560             


Lys Lys  Ser Phe Leu Asn Leu  Phe Gln Asp Asp Lys  Ile Glu Asn 
    1565                 1570                 1575             


Ile Asp  Phe Lys Phe Lys Ser  Met Asp Phe Lys Glu  Lys Cys Lys 
    1580                 1585                 1590             


Thr Leu  Leu Met Leu Val Lys  Ala Ile Arg Ala Ser  Gly Val Arg 
    1595                 1600                 1605             


Gln Asp  Leu Lys Ser Ile Asp  Leu Lys Ser Asp Tyr  Gly Arg Leu 
    1610                 1615                 1620             


Ser Ser  Lys Thr Asn Asn Ile  Gly Asn Tyr Gln Glu  Phe Lys Ile 
    1625                 1630                 1635             


Ile Asn  Gln Ser Ile Thr Gly  Leu Phe Glu Asn Glu  Val Asp Leu 
    1640                 1645                 1650             


Leu Lys  Leu Gly Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1655                 1660                 1665             


Ala Lys  Lys Lys Lys Gly Ser  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1670                 1675                 1680             


Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys 
    1685                 1690                 1695             


Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val 
    1700                 1705                 1710             


Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser Asp Ile  Leu Val His 
    1715                 1720                 1725             


Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr 
    1730                 1735                 1740             


Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp 
    1745                 1750                 1755             


Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu Ser Gly  Gly Ser Gly 
    1760                 1765                 1770             


Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1775                 1780                 1785             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1790                 1795                 1800             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1805                 1810                 1815             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1820                 1825                 1830             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1835                 1840                 1845             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Tyr Pro 
    1850                 1855                 1860             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1865                 1870                 1875             


Ala Tyr  
    1880 


<210> 19
<211> 112
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
guuugagagu uauguaauug aaaaauuaca ugacgaguuc aaauaaaaau uuauucaaac       60

cgccuauuua uaggccgcag auguucugca uuaugcuugc uauugcaagc uu              112


<210> 20
<211> 1595
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Gly Lys Pro 
        195                 200                 205             


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
    210                 215                 220                 


Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly 
225                 230                 235                 240 


Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu 
                245                 250                 255     


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
            260                 265                 270         


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu 
        275                 280                 285             


Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn Phe Phe Gln Arg 
    290                 295                 300                 


Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg Gly Glu His His 
305                 310                 315                 320 


Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr His Asp Asp Phe 
                325                 330                 335     


Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp Thr Ser Lys Lys 
            340                 345                 350         


Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
        355                 360                 365             


Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp 
    370                 375                 380                 


Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile 
385                 390                 395                 400 


Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala Leu Ser Ile Leu 
                405                 410                 415     


Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn Leu Ile Ala His 
            420                 425                 430         


Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu 
        435                 440                 445             


Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu 
465                 470                 475                 480 


Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser 
                485                 490                 495     


Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu Thr Val 
            500                 505                 510         


Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg 
        515                 520                 525             


Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys 
    530                 535                 540                 


Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys 
545                 550                 555                 560 


Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys Gln Asp Glu Phe 
                565                 570                 575     


Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp 
            580                 585                 590         


Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr 
        595                 600                 605             


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His 
    610                 615                 620                 


Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn 
625                 630                 635                 640 


Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
                645                 650                 655     


Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys 
            660                 665                 670         


Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys 
        675                 680                 685             


Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu 
    690                 695                 700                 


Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu 
705                 710                 715                 720 


Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu 
                725                 730                 735     


Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe 
            740                 745                 750         


Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu 
        755                 760                 765             


Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr 
    770                 775                 780                 


Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr 
785                 790                 795                 800 


His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala 
                805                 810                 815     


Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu 
            820                 825                 830         


Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe 
        835                 840                 845             


Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp 
    850                 855                 860                 


Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn 
865                 870                 875                 880 


Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg 
                885                 890                 895     


Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu 
            900                 905                 910         


Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp Ile Ala Asn Val 
        915                 920                 925             


Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
    930                 935                 940                 


Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro 
945                 950                 955                 960 


Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys 
                965                 970                 975     


Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu 
            980                 985                 990         


Lys Asn Leu Asp Asn Pro Val Asn  Ile Lys Asn Val Glu  Asn Gln Gln 
        995                 1000                 1005             


Leu Gln  Asn Asp Arg Leu Phe  Leu Tyr Tyr Ile Gln  Asn Gly Lys 
    1010                 1015                 1020             


Asp Met  Tyr Thr Gly Glu Thr  Leu Asp Ile Asn Asn  Leu Ser Gln 
    1025                 1030                 1035             


Tyr Asp  Ile Asp His Ile Ile  Pro Gln Ala Phe Ile  Lys Asp Asn 
    1040                 1045                 1050             


Ser Leu  Asp Asn Arg Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1055                 1060                 1065             


Lys Ser  Asp Asp Val Pro Ser  Ile Glu Val Val His  Glu Met Lys 
    1070                 1075                 1080             


Ser Phe  Trp Ser Lys Leu Leu  Ser Val Lys Leu Ile  Thr Gln Arg 
    1085                 1090                 1095             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Thr Glu 
    1100                 1105                 1110             


Glu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1115                 1120                 1125             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Glu  Arg Phe Asn 
    1130                 1135                 1140             


Thr Glu  Phe Asp Gly Asn Lys  Arg Arg Ile Arg Asn  Val Lys Ile 
    1145                 1150                 1155             


Ile Thr  Leu Lys Ser Asn Leu  Val Ser Asn Phe Arg  Lys Glu Phe 
    1160                 1165                 1170             


Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp Tyr His  His Ala His 
    1175                 1180                 1185             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Asn Ala Leu  Leu Leu Lys 
    1190                 1195                 1200             


Tyr Pro  Gln Leu Glu Pro Glu  Phe Val Tyr Gly Glu  Tyr Pro Lys 
    1205                 1210                 1215             


Tyr Asn  Ser Tyr Arg Ser Arg  Lys Ser Ala Thr Glu  Lys Phe Leu 
    1220                 1225                 1230             


Phe Tyr  Ser Asn Ile Leu Arg  Phe Phe Lys Lys Glu  Asp Ile Gln 
    1235                 1240                 1245             


Thr Asn  Glu Asp Gly Glu Ile  Ala Trp Asn Lys Glu  Lys His Ile 
    1250                 1255                 1260             


Lys Ile  Leu Arg Lys Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val 
    1265                 1270                 1275             


Lys Lys  Thr Glu Glu Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1280                 1285                 1290             


Leu Pro  Lys Gly Glu Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys 
    1295                 1300                 1305             


Asn Ser  Tyr Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1310                 1315                 1320             


Val Val  Ala Tyr Ser Ile Leu  Val Phe Ala Asp Val  Glu Lys Gly 
    1325                 1330                 1335             


Lys Ser  Lys Lys Leu Arg Lys  Val Gln Asp Met Val  Gly Ile Thr 
    1340                 1345                 1350             


Ile Met  Glu Lys Lys Arg Phe  Glu Lys Asn Pro Val  Asp Phe Leu 
    1355                 1360                 1365             


Glu Gln  Arg Gly Tyr Arg Asn  Val Arg Leu Glu Lys  Ile Ile Lys 
    1370                 1375                 1380             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Lys  Arg Arg Arg 
    1385                 1390                 1395             


Leu Leu  Ala Ser Ala Lys Glu  Leu Gln Lys Gly Asn  Glu Leu Val 
    1400                 1405                 1410             


Ile Pro  Gln Arg Phe Thr Thr  Leu Leu Tyr His Ser  Tyr Arg Ile 
    1415                 1420                 1425             


Glu Lys  Asp Tyr Glu Pro Glu  His Arg Glu Tyr Val  Glu Lys His 
    1430                 1435                 1440             


Lys Asp  Glu Phe Lys Glu Leu  Leu Glu Tyr Ile Ser  Val Phe Ser 
    1445                 1450                 1455             


Arg Lys  Tyr Val Leu Ala Asp  Asn Asn Leu Thr Lys  Ile Glu Met 
    1460                 1465                 1470             


Leu Phe  Ser Lys Asn Lys Asp  Ala Glu Val Ser Ser  Leu Ala Lys 
    1475                 1480                 1485             


Ser Phe  Ile Ser Leu Leu Thr  Phe Thr Ala Phe Gly  Ala Pro Ala 
    1490                 1495                 1500             


Ala Phe  Asn Phe Phe Gly Glu  Asn Ile Asp Arg Lys  Arg Tyr Thr 
    1505                 1510                 1515             


Ser Val  Thr Glu Cys Leu Asn  Ala Thr Leu Ile His  Gln Ser Ile 
    1520                 1525                 1530             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Lys  Leu Gly Glu 
    1535                 1540                 1545             


Asp Gly  Lys Arg Pro Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys 
    1550                 1555                 1560             


Lys Lys  Lys Gly Ser Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Tyr 
    1565                 1570                 1575             


Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp 
    1580                 1585                 1590             


Tyr Ala  
    1595 


<210> 21
<211> 1863
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Ser Glu Lys Gly Pro 
1               5                   10                  15      


Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Ser Trp Glu Phe 
            20                  25                  30          


Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu 
        35                  40                  45              


Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly 
    50                  55                  60                  


Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr 
65                  70                  75                  80  


Ser Glu Arg Arg Phe His Ser Ser Ile Ser Cys Ser Ile Thr Trp Phe 
                85                  90                  95      


Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe 
            100                 105                 110         


Leu Ser Gln His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu 
        115                 120                 125             


Phe Trp His Met Asp Gln Arg Asn Arg Gln Gly Leu Arg Asp Leu Val 
    130                 135                 140                 


Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His 
145                 150                 155                 160 


Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp 
                165                 170                 175     


Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His 
            180                 185                 190         


Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp 
        195                 200                 205             


Gln Asn His Leu Ala Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr 
    210                 215                 220                 


Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro 
225                 230                 235                 240 


Ser Val Thr Trp Arg Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly 
        275                 280                 285             


Lys Pro Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
    290                 295                 300                 


Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val 
305                 310                 315                 320 


Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu Gly Ala 
                325                 330                 335     


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
            340                 345                 350         


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg Tyr Leu 
        355                 360                 365             


Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn Phe Phe 
    370                 375                 380                 


Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg Gly Glu 
385                 390                 395                 400 


His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr His Asp 
                405                 410                 415     


Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp Thr Ser 
            420                 425                 430         


Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His Met Ile 
        435                 440                 445             


Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala Glu Asn 
    450                 455                 460                 


Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr Asp Lys 
465                 470                 475                 480 


Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala Leu Ser 
                485                 490                 495     


Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn Leu Ile 
            500                 505                 510         


Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile 
        515                 520                 525             


Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe Gln Leu 
    530                 535                 540                 


Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp 
545                 550                 555                 560 


Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp Leu Phe 
                565                 570                 575     


Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu 
            580                 585                 590         


Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Val 
        595                 600                 605             


Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys Asp Phe 
    610                 615                 620                 


Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys Asp Lys 
625                 630                 635                 640 


Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys Gln Asp 
                645                 650                 655     


Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn Gly Ser 
            660                 665                 670         


Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln 
        675                 680                 685             


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu 
    690                 695                 700                 


Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys 
705                 710                 715                 720 


Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
                725                 730                 735     


Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu 
            740                 745                 750         


Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu 
        755                 760                 765             


Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn 
    770                 775                 780                 


Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu 
785                 790                 795                 800 


Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
                805                 810                 815     


Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu 
            820                 825                 830         


Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys 
        835                 840                 845             


Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn 
    850                 855                 860                 


Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly 
865                 870                 875                 880 


Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp 
                885                 890                 895     


Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu 
            900                 905                 910         


Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp 
        915                 920                 925             


Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr 
    930                 935                 940                 


Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys 
945                 950                 955                 960 


Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala 
                965                 970                 975     


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys 
            980                 985                 990         


Glu Glu Ile Ala Arg Ala Gln Ile  Ile Asp Asp Val Asp  Asp Ile Ala 
        995                 1000                 1005             


Asn Val  Val His Asp Leu Pro  Gly Ser Pro Ala Ile  Lys Lys Gly 
    1010                 1015                 1020             


Ile Leu  Gln Ser Val Lys Ile  Val Asp Glu Leu Val  Lys Val Met 
    1025                 1030                 1035             


Gly His  Asn Pro Ala Asn Ile  Ile Ile Glu Met Ala  Arg Glu Asn 
    1040                 1045                 1050             


Gln Thr  Thr Asp Lys Gly Arg  Arg Asn Ser Gln Gln  Arg Leu Lys 
    1055                 1060                 1065             


Leu Leu  Gln Asp Ser Leu Lys  Asn Leu Asp Asn Pro  Val Asn Ile 
    1070                 1075                 1080             


Lys Asn  Val Glu Asn Gln Gln  Leu Gln Asn Asp Arg  Leu Phe Leu 
    1085                 1090                 1095             


Tyr Tyr  Ile Gln Asn Gly Lys  Asp Met Tyr Thr Gly  Glu Thr Leu 
    1100                 1105                 1110             


Asp Ile  Asn Asn Leu Ser Gln  Tyr Asp Ile Asp His  Ile Ile Pro 
    1115                 1120                 1125             


Gln Ala  Phe Ile Lys Asp Asn  Ser Leu Asp Asn Arg  Val Leu Thr 
    1130                 1135                 1140             


Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp Asp Val  Pro Ser Ile 
    1145                 1150                 1155             


Glu Val  Val His Glu Met Lys  Ser Phe Trp Ser Lys  Leu Leu Ser 
    1160                 1165                 1170             


Val Lys  Leu Ile Thr Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala 
    1175                 1180                 1185             


Glu Arg  Gly Gly Leu Thr Glu  Glu Asp Lys Ala Gly  Phe Ile Lys 
    1190                 1195                 1200             


Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr Lys His  Val Ala Gln 
    1205                 1210                 1215             


Ile Leu  Asp Glu Arg Phe Asn  Thr Glu Phe Asp Gly  Asn Lys Arg 
    1220                 1225                 1230             


Arg Ile  Arg Asn Val Lys Ile  Ile Thr Leu Lys Ser  Asn Leu Val 
    1235                 1240                 1245             


Ser Asn  Phe Arg Lys Glu Phe  Glu Leu Tyr Lys Val  Arg Glu Ile 
    1250                 1255                 1260             


Asn Asp  Tyr His His Ala His  Asp Ala Tyr Leu Asn  Ala Val Val 
    1265                 1270                 1275             


Gly Asn  Ala Leu Leu Leu Lys  Tyr Pro Gln Leu Glu  Pro Glu Phe 
    1280                 1285                 1290             


Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser Tyr Arg  Ser Arg Lys 
    1295                 1300                 1305             


Ser Ala  Thr Glu Lys Phe Leu  Phe Tyr Ser Asn Ile  Leu Arg Phe 
    1310                 1315                 1320             


Phe Lys  Lys Glu Asp Ile Gln  Thr Asn Glu Asp Gly  Glu Ile Ala 
    1325                 1330                 1335             


Trp Asn  Lys Glu Lys His Ile  Lys Ile Leu Arg Lys  Val Leu Ser 
    1340                 1345                 1350             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Glu  Gln Thr Gly 
    1355                 1360                 1365             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Gly Glu  Ser Asp Lys 
    1370                 1375                 1380             


Leu Ile  Pro Arg Lys Thr Lys  Asn Ser Tyr Trp Asp  Pro Lys Lys 
    1385                 1390                 1395             


Tyr Gly  Gly Phe Asp Ser Pro  Val Val Ala Tyr Ser  Ile Leu Val 
    1400                 1405                 1410             


Phe Ala  Asp Val Glu Lys Gly  Lys Ser Lys Lys Leu  Arg Lys Val 
    1415                 1420                 1425             


Gln Asp  Met Val Gly Ile Thr  Ile Met Glu Lys Lys  Arg Phe Glu 
    1430                 1435                 1440             


Lys Asn  Pro Val Asp Phe Leu  Glu Gln Arg Gly Tyr  Arg Asn Val 
    1445                 1450                 1455             


Arg Leu  Glu Lys Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1460                 1465                 1470             


Leu Glu  Asn Lys Arg Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu 
    1475                 1480                 1485             


Gln Lys  Gly Asn Glu Leu Val  Ile Pro Gln Arg Phe  Thr Thr Leu 
    1490                 1495                 1500             


Leu Tyr  His Ser Tyr Arg Ile  Glu Lys Asp Tyr Glu  Pro Glu His 
    1505                 1510                 1515             


Arg Glu  Tyr Val Glu Lys His  Lys Asp Glu Phe Lys  Glu Leu Leu 
    1520                 1525                 1530             


Glu Tyr  Ile Ser Val Phe Ser  Arg Lys Tyr Val Leu  Ala Asp Asn 
    1535                 1540                 1545             


Asn Leu  Thr Lys Ile Glu Met  Leu Phe Ser Lys Asn  Lys Asp Ala 
    1550                 1555                 1560             


Glu Val  Ser Ser Leu Ala Lys  Ser Phe Ile Ser Leu  Leu Thr Phe 
    1565                 1570                 1575             


Thr Ala  Phe Gly Ala Pro Ala  Ala Phe Asn Phe Phe  Gly Glu Asn 
    1580                 1585                 1590             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Val Thr Glu Cys  Leu Asn Ala 
    1595                 1600                 1605             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1610                 1615                 1620             


Asp Leu  Ser Lys Leu Gly Glu  Asp Gly Lys Arg Pro  Ala Ala Thr 
    1625                 1630                 1635             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Gly Ser  Ser Gly Gly 
    1640                 1645                 1650             


Ser Gly  Gly Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1655                 1660                 1665             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1670                 1675                 1680             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1685                 1690                 1695             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    1700                 1705                 1710             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    1715                 1720                 1725             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    1730                 1735                 1740             


Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp 
    1745                 1750                 1755             


Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser 
    1760                 1765                 1770             


Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys 
    1775                 1780                 1785             


Pro Glu  Ser Asp Ile Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr 
    1790                 1795                 1800             


Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys 
    1805                 1810                 1815             


Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile 
    1820                 1825                 1830             


Lys Met  Leu Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr 
    1835                 1840                 1845             


Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1850                 1855                 1860             


<210> 22
<211> 208
<212> PRT
<213> Petromyzon marinus

<400> 22
Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210> 23
<211> 145
<212> PRT
<213> Homo sapiens

<400> 23
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Ala Pro 
    130                 135                 140                 


Val 
145 


<210> 24
<211> 198
<212> PRT
<213> Homo sapiens

<400> 24
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 25
<211> 198
<212> PRT
<213> Mus sp.

<400> 25
Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210> 26
<211> 198
<212> PRT
<213> Canis lupus familiaris

<400> 26
Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 27
<211> 199
<212> PRT
<213> Bos sp.

<400> 27
Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210> 28
<211> 239
<212> PRT
<213> Rattus sp.

<400> 28
Met Ala Val Gly Ser Lys Pro Lys Ala Ala Leu Val Gly Pro His Trp 
1               5                   10                  15      


Glu Arg Glu Arg Ile Trp Cys Phe Leu Cys Ser Thr Gly Leu Gly Thr 
            20                  25                  30          


Gln Gln Thr Gly Gln Thr Ser Arg Trp Leu Arg Pro Ala Ala Thr Gln 
        35                  40                  45              


Asp Pro Val Ser Pro Pro Arg Ser Leu Leu Met Lys Gln Arg Lys Phe 
    50                  55                  60                  


Leu Tyr His Phe Lys Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr 
65                  70                  75                  80  


Tyr Leu Cys Tyr Val Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser 
                85                  90                  95      


Leu Asp Phe Gly Tyr Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu 
            100                 105                 110         


Leu Phe Leu Arg Tyr Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys 
        115                 120                 125             


Tyr Arg Val Thr Trp Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala 
    130                 135                 140                 


Arg His Val Ala Asp Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg 
145                 150                 155                 160 


Ile Phe Thr Ala Arg Leu Thr Gly Trp Gly Ala Leu Pro Ala Gly Leu 
                165                 170                 175     


Met Ser Pro Ala Arg Pro Ser Asp Tyr Phe Tyr Cys Trp Asn Thr Phe 
            180                 185                 190         


Val Glu Asn His Glu Arg Thr Phe Lys Ala Trp Glu Gly Leu His Glu 
        195                 200                 205             


Asn Ser Val Arg Leu Ser Arg Arg Leu Arg Arg Ile Leu Leu Pro Leu 
    210                 215                 220                 


Tyr Glu Val Asp Asp Leu Arg Asp Ala Phe Arg Thr Leu Gly Leu 
225                 230                 235                 


<210> 29
<211> 198
<212> PRT
<213> Canis lupus familiaris

<400> 29
Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 30
<211> 199
<212> PRT
<213> Bos taurus

<400> 30
Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210> 31
<211> 198
<212> PRT
<213> Mus musculus

<400> 31
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 32
<211> 229
<212> PRT
<213> Rattus norvegicus

<400> 32
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210> 33
<211> 229
<212> PRT
<213> Mesocricetus auratus

<400> 33
Met Ser Ser Glu Thr Gly Pro Val Val Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Asp Ala Phe Phe Asp Gln Gly Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Arg Trp Gly Gly Arg His 
        35                  40                  45              


Asn Ile Trp Arg His Thr Gly Gln Asn Thr Ser Arg His Val Glu Ile 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Ser Glu Arg Tyr Phe Tyr Pro Ser Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Val Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Lys Ala Ile Thr Glu Phe Leu Ser Gly His Pro Asn Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ala Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Arg Gly Val Thr Ile Arg Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Ser Asn Glu Val Tyr Trp Pro Arg Tyr Pro Asn Leu Trp Met Arg 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu Tyr Cys Ile His Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Lys Arg Arg His Gln Tyr Pro Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


Asn Leu Gln Ser Cys His Tyr Gln Arg Ile Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Phe Ile 
225                 


<210> 34
<211> 236
<212> PRT
<213> Pongo pygmaeus

<400> 34
Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Ser Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Arg Phe His Ser Ser Ile 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Gln His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Ala Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Thr Trp Arg 
225                 230                 235     


<210> 35
<211> 236
<212> PRT
<213> Oryctolagus cuniculus

<400> 35
Met Ala Ser Glu Lys Gly Pro Ser Asn Lys Asp Tyr Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Glu Val Phe Phe Asp Pro Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Ala Ser Ser 
        35                  40                  45              


Lys Thr Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Leu Glu Lys Leu Thr Ser Glu Gly Arg Leu Gly Pro Ser Thr 
65                  70                  75                  80  


Cys Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Met Ala Ile Arg Glu Phe Leu Ser Gln His Pro Gly Val Thr Leu 
            100                 105                 110         


Ile Ile Phe Val Ala Arg Leu Phe Gln His Met Asp Arg Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Lys Asp Leu Val Thr Ser Gly Val Thr Val Arg Val Met 
    130                 135                 140                 


Ser Val Ser Glu Tyr Cys Tyr Cys Trp Glu Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Lys Ala Ala Gln Trp Pro Arg Tyr Pro Pro Arg Trp Met Leu 
                165                 170                 175     


Met Tyr Ala Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg His Gln Lys Gln Leu Thr Phe Phe Ser Leu 
        195                 200                 205             


Thr Pro Gln Tyr Cys His Tyr Lys Met Ile Pro Pro Tyr Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Leu Gln Pro Ser Val Pro Trp Arg 
225                 230                 235     


<210> 36
<211> 235
<212> PRT
<213> Monodelphis domestica

<400> 36
Met Asn Ser Lys Thr Gly Pro Ser Val Gly Asp Ala Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Lys Pro Trp Glu Phe Val Ala Phe Phe Asn Pro Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Lys Trp Gly Asn Gln Asn 
        35                  40                  45              


Ile Trp Arg His Ser Asn Gln Asn Thr Ser Gln His Ala Glu Ile Asn 
    50                  55                  60                  


Phe Met Glu Lys Phe Thr Ala Glu Arg His Phe Asn Ser Ser Val Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser 
                85                  90                  95      


Lys Ala Ile Arg Lys Phe Leu Asp His Tyr Pro Asn Val Thr Leu Ala 
            100                 105                 110         


Ile Phe Ile Ser Arg Leu Tyr Trp His Met Asp Gln Gln His Arg Gln 
        115                 120                 125             


Gly Leu Lys Glu Leu Val His Ser Gly Val Thr Ile Gln Ile Met Ser 
    130                 135                 140                 


Tyr Ser Glu Tyr His Tyr Cys Trp Arg Asn Phe Val Asp Tyr Pro Gln 
145                 150                 155                 160 


Gly Glu Glu Asp Tyr Trp Pro Lys Tyr Pro Tyr Leu Trp Ile Met Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu His Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Lys Ile Ser Gly Ser His Ser Asn Gln Leu Ala Leu Phe Ser Leu Asp 
        195                 200                 205             


Leu Gln Asp Cys His Tyr Gln Lys Ile Pro Tyr Asn Val Leu Val Ala 
    210                 215                 220                 


Thr Gly Leu Val Gln Pro Phe Val Thr Trp Arg 
225                 230                 235 


<210> 37
<211> 224
<212> PRT
<213> Pongo pygmaeus

<400> 37
Met Ala Gln Lys Glu Glu Ala Ala Ala Ala Thr Glu Ala Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Asp Leu Glu Asn Leu Asp Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Gly Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Ala 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Ile Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Leu 
145                 150                 155                 160 


Glu Ile Gln Asp Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Val Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Gln Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 38
<211> 224
<212> PRT
<213> Bos taurus

<400> 38
Met Ala Gln Lys Glu Glu Ala Ala Ala Ala Ala Glu Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Glu Val Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala His Tyr Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Thr 
                85                  90                  95      


Asn His Ala Glu Glu Ala Phe Phe Asn Ser Ile Met Pro Thr Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Met Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Val Lys Thr Leu Asn Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Arg Lys Leu Lys Glu Ala Gly Cys Arg Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Ile Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 39
<211> 440
<212> PRT
<213> Mus musculus

<400> 39
Met Gln Pro Gln Arg Leu Gly Pro Arg Ala Gly Met Gly Pro Phe Cys 
1               5                   10                  15      


Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro Ile Arg Asn Leu Ile 
            20                  25                  30          


Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn Leu Gly Tyr Ala Lys 
        35                  40                  45              


Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val Thr Arg Lys Asp Cys 
    50                  55                  60                  


Asp Ser Pro Val Ser Leu His His Gly Val Phe Lys Asn Lys Asp Asn 
65                  70                  75                  80  


Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe His Asp Lys Val Leu 
                85                  90                  95      


Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile Thr Trp Tyr Met Ser 
            100                 105                 110         


Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile Val Arg Phe Leu Ala 
        115                 120                 125             


Thr His His Asn Leu Ser Leu Asp Ile Phe Ser Ser Arg Leu Tyr Asn 
    130                 135                 140                 


Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys Arg Leu Val Gln Glu 
145                 150                 155                 160 


Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu Phe Lys Lys Cys Trp 
                165                 170                 175     


Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe Arg Pro Trp Lys Arg 
            180                 185                 190         


Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys Leu Gln Glu Ile Leu 
        195                 200                 205             


Arg Pro Cys Tyr Ile Ser Val Pro Ser Ser Ser Ser Ser Thr Leu Ser 
    210                 215                 220                 


Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr Arg Phe Trp Val Glu 
225                 230                 235                 240 


Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu Phe Tyr Ser Gln Phe 
                245                 250                 255     


Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr His Arg Met Lys Pro 
            260                 265                 270         


Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly Gln Ala Pro Leu Lys 
        275                 280                 285             


Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His Ala Glu Ile Leu Phe 
    290                 295                 300                 


Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln Val Thr Ile Thr Cys 
305                 310                 315                 320 


Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala Trp Gln Leu Ala Ala 
                325                 330                 335     


Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His Ile Tyr Thr Ser Arg 
            340                 345                 350         


Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys Gly Leu Cys Ser Leu 
        355                 360                 365             


Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp Leu Pro Gln Phe Thr 
    370                 375                 380                 


Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg Pro Phe Trp Pro Trp 
385                 390                 395                 400 


Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln Arg Arg Leu Arg Arg 
                405                 410                 415     


Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val Asn Asp Phe Gly Asn 
            420                 425                 430         


Leu Gln Leu Gly Pro Pro Met Ser 
        435                 440 


<210> 40
<211> 429
<212> PRT
<213> Mus sp.

<400> 40
Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210> 41
<211> 430
<212> PRT
<213> Rattus sp.

<400> 41
Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Arg Leu Arg Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu 
        35                  40                  45              


Val Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val 
    50                  55                  60                  


Phe Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp 
65                  70                  75                  80  


Phe His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys 
                85                  90                  95      


Ile Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln 
            100                 105                 110         


Val Leu Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe 
        115                 120                 125             


Ser Ser Arg Leu Tyr Asn Ile Arg Asp Pro Glu Asn Gln Gln Asn Leu 
    130                 135                 140                 


Cys Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr 
145                 150                 155                 160 


Glu Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg 
                165                 170                 175     


Phe Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser 
            180                 185                 190         


Lys Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser 
        195                 200                 205             


Ser Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu 
    210                 215                 220                 


Thr Arg Phe Cys Val Glu Arg Arg Arg Val His Leu Leu Ser Glu Glu 
225                 230                 235                 240 


Glu Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr 
                245                 250                 255     


Tyr His Gly Val Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn 
            260                 265                 270         


Gly Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln 
        275                 280                 285             


His Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser 
    290                 295                 300                 


Gln Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys 
305                 310                 315                 320 


Ala Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu 
                325                 330                 335     


His Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln 
            340                 345                 350         


Lys Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met 
        355                 360                 365             


Asp Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys 
    370                 375                 380                 


Arg Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr 
385                 390                 395                 400 


Gln Arg Arg Leu His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu 
                405                 410                 415     


Val Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 430 


<210> 42
<211> 199
<212> PRT
<213> Homo sapiens

<400> 42
Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210> 43
<211> 373
<212> PRT
<213> Homo sapiens

<400> 43
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210> 44
<211> 370
<212> PRT
<213> Macaca mulatta

<400> 44
Met Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 
1               5                   10                  15      


Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val 
            20                  25                  30          


Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile Phe Gln 
        35                  40                  45              


Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu Met Arg Phe Leu 
    50                  55                  60                  


Arg Trp Phe His Lys Trp Arg Gln Leu His His Asp Gln Glu Tyr Lys 
65                  70                  75                  80  


Val Thr Trp Tyr Val Ser Trp Ser Pro Cys Thr Arg Cys Ala Asn Ser 
                85                  90                  95      


Val Ala Thr Phe Leu Ala Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 
            100                 105                 110         


Val Ala Arg Leu Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 
        115                 120                 125             


Arg Ile Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 
    130                 135                 140                 


Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp Gly 
145                 150                 155                 160 


Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro Lys His Tyr Thr 
                165                 170                 175     


Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu Arg His Leu Met Asp Pro 
            180                 185                 190         


Gly Thr Phe Thr Ser Asn Phe Asn Asn Lys Pro Trp Val Ser Gly Gln 
        195                 200                 205             


His Glu Thr Tyr Leu Cys Tyr Lys Val Glu Arg Leu His Asn Asp Thr 
    210                 215                 220                 


Trp Val Pro Leu Asn Gln His Arg Gly Phe Leu Arg Asn Gln Ala Pro 
225                 230                 235                 240 


Asn Ile His Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 
                245                 250                 255     


Asp Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr 
            260                 265                 270         


Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala 
        275                 280                 285             


Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys Ile Phe Ala Ala 
    290                 295                 300                 


Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln Glu Gly Leu Arg Ala Leu 
305                 310                 315                 320 


His Arg Asp Gly Ala Lys Ile Ala Met Met Asn Tyr Ser Glu Phe Glu 
                325                 330                 335     


Tyr Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe Gln Pro 
            340                 345                 350         


Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 
        355                 360                 365             


Ala Ile 
    370 


<210> 45
<211> 384
<212> PRT
<213> Pan troglodytes

<400> 45
Met Lys Pro His Phe Arg Asn Pro Val Glu Arg Met Tyr Gln Asp Thr 
1               5                   10                  15      


Phe Ser Asp Asn Phe Tyr Asn Arg Pro Ile Leu Ser His Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Lys Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Glu Leu Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Leu His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu His Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Asn Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Lys Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 
        355                 360                 365             


Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380                 


<210> 46
<211> 377
<212> PRT
<213> Chlorocebus sp.

<400> 46
Met Asn Pro Gln Ile Arg Asn Met Val Glu Gln Met Glu Pro Asp Ile 
1               5                   10                  15      


Phe Val Tyr Tyr Phe Asn Asn Arg Pro Ile Leu Ser Gly Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Asp Pro Ser Gly Pro Pro 
        35                  40                  45              


Leu Asp Ala Asn Ile Phe Gln Gly Lys Leu Tyr Pro Glu Ala Lys Asp 
    50                  55                  60                  


His Pro Glu Met Lys Phe Leu His Trp Phe Arg Lys Trp Arg Gln Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Val Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Arg Cys Ala Asn Ser Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Lys 
        115                 120                 125             


Pro Asp Tyr Gln Gln Ala Leu Arg Ile Leu Cys Gln Glu Arg Gly Gly 
    130                 135                 140                 


Pro His Ala Thr Met Lys Ile Met Asn Tyr Asn Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Asn Glu Phe Val Asp Gly Gln Gly Lys Pro Phe Lys Pro Arg Lys 
                165                 170                 175     


Asn Leu Pro Lys His Tyr Thr Leu Leu His Ala Thr Leu Gly Glu Leu 
            180                 185                 190         


Leu Arg His Val Met Asp Pro Gly Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Lys Pro Trp Val Ser Gly Gln Arg Glu Thr Tyr Leu Cys Tyr Lys Val 
    210                 215                 220                 


Glu Arg Ser His Asn Asp Thr Trp Val Leu Leu Asn Gln His Arg Gly 
225                 230                 235                 240 


Phe Leu Arg Asn Gln Ala Pro Asp Arg His Gly Phe Pro Lys Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Leu Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Asp Gln Gln Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Gln Lys Met Ala Lys Phe Ile Ser Asn Asn Lys His Val 
    290                 295                 300                 


Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys 
305                 310                 315                 320 


Gln Glu Gly Leu Arg Thr Leu His Arg Asp Gly Ala Lys Ile Ala Val 
                325                 330                 335     


Met Asn Tyr Ser Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Asp Arg 
            340                 345                 350         


Gln Gly Arg Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
        355                 360                 365             


Ala Leu Ser Gly Arg Leu Arg Ala Ile 
    370                 375         


<210> 47
<211> 384
<212> PRT
<213> Homo sapiens

<400> 47
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210> 48
<211> 373
<212> PRT
<213> Homo sapiens

<400> 48
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210> 49
<211> 382
<212> PRT
<213> Homo sapiens

<400> 49
Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


<210> 50
<211> 395
<212> PRT
<213> Rattus sp.

<400> 50
Met Gln Pro Gln Gly Leu Gly Pro Asn Ala Gly Met Gly Pro Val Cys 
1               5                   10                  15      


Leu Gly Cys Ser His Arg Arg Pro Tyr Ser Pro Ile Arg Asn Pro Leu 
            20                  25                  30          


Lys Lys Leu Tyr Gln Gln Thr Phe Tyr Phe His Phe Lys Asn Val Arg 
        35                  40                  45              


Tyr Ala Trp Gly Arg Lys Asn Asn Phe Leu Cys Tyr Glu Val Asn Gly 
    50                  55                  60                  


Met Asp Cys Ala Leu Pro Val Pro Leu Arg Gln Gly Val Phe Arg Lys 
65                  70                  75                  80  


Gln Gly His Ile His Ala Glu Leu Cys Phe Ile Tyr Trp Phe His Asp 
                85                  90                  95      


Lys Val Leu Arg Val Leu Ser Pro Met Glu Glu Phe Lys Val Thr Trp 
            100                 105                 110         


Tyr Met Ser Trp Ser Pro Cys Ser Lys Cys Ala Glu Gln Val Ala Arg 
        115                 120                 125             


Phe Leu Ala Ala His Arg Asn Leu Ser Leu Ala Ile Phe Ser Ser Arg 
    130                 135                 140                 


Leu Tyr Tyr Tyr Leu Arg Asn Pro Asn Tyr Gln Gln Lys Leu Cys Arg 
145                 150                 155                 160 


Leu Ile Gln Glu Gly Val His Val Ala Ala Met Asp Leu Pro Glu Phe 
                165                 170                 175     


Lys Lys Cys Trp Asn Lys Phe Val Asp Asn Asp Gly Gln Pro Phe Arg 
            180                 185                 190         


Pro Trp Met Arg Leu Arg Ile Asn Phe Ser Phe Tyr Asp Cys Lys Leu 
        195                 200                 205             


Gln Glu Ile Phe Ser Arg Met Asn Leu Leu Arg Glu Asp Val Phe Tyr 
    210                 215                 220                 


Leu Gln Phe Asn Asn Ser His Arg Val Lys Pro Val Gln Asn Arg Tyr 
225                 230                 235                 240 


Tyr Arg Arg Lys Ser Tyr Leu Cys Tyr Gln Leu Glu Arg Ala Asn Gly 
                245                 250                 255     


Gln Glu Pro Leu Lys Gly Tyr Leu Leu Tyr Lys Lys Gly Glu Gln His 
            260                 265                 270         


Val Glu Ile Leu Phe Leu Glu Lys Met Arg Ser Met Glu Leu Ser Gln 
        275                 280                 285             


Val Arg Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
    290                 295                 300                 


Arg Gln Leu Ala Ala Phe Lys Lys Asp His Pro Asp Leu Ile Leu Arg 
305                 310                 315                 320 


Ile Tyr Thr Ser Arg Leu Tyr Phe Trp Arg Lys Lys Phe Gln Lys Gly 
                325                 330                 335     


Leu Cys Thr Leu Trp Arg Ser Gly Ile His Val Asp Val Met Asp Leu 
            340                 345                 350         


Pro Gln Phe Ala Asp Cys Trp Thr Asn Phe Val Asn Pro Gln Arg Pro 
        355                 360                 365             


Phe Arg Pro Trp Asn Glu Leu Glu Lys Asn Ser Trp Arg Ile Gln Arg 
    370                 375                 380                 


Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu 
385                 390                 395 


<210> 51
<211> 227
<212> PRT
<213> Bos sp.

<400> 51
Met Asp Gly Trp Glu Val Ala Phe Arg Ser Gly Thr Val Leu Lys Ala 
1               5                   10                  15      


Gly Val Leu Gly Val Ser Met Thr Glu Gly Trp Ala Gly Ser Gly His 
            20                  25                  30          


Pro Gly Gln Gly Ala Cys Val Trp Thr Pro Gly Thr Arg Asn Thr Met 
        35                  40                  45              


Asn Leu Leu Arg Glu Val Leu Phe Lys Gln Gln Phe Gly Asn Gln Pro 
    50                  55                  60                  


Arg Val Pro Ala Pro Tyr Tyr Arg Arg Lys Thr Tyr Leu Cys Tyr Gln 
65                  70                  75                  80  


Leu Lys Gln Arg Asn Asp Leu Thr Leu Asp Arg Gly Cys Phe Arg Asn 
                85                  90                  95      


Lys Lys Gln Arg His Ala Glu Arg Phe Ile Asp Lys Ile Asn Ser Leu 
            100                 105                 110         


Asp Leu Asn Pro Ser Gln Ser Tyr Lys Ile Ile Cys Tyr Ile Thr Trp 
        115                 120                 125             


Ser Pro Cys Pro Asn Cys Ala Asn Glu Leu Val Asn Phe Ile Thr Arg 
    130                 135                 140                 


Asn Asn His Leu Lys Leu Glu Ile Phe Ala Ser Arg Leu Tyr Phe His 
145                 150                 155                 160 


Trp Ile Lys Ser Phe Lys Met Gly Leu Gln Asp Leu Gln Asn Ala Gly 
                165                 170                 175     


Ile Ser Val Ala Val Met Thr His Thr Glu Phe Glu Asp Cys Trp Glu 
            180                 185                 190         


Gln Phe Val Asp Asn Gln Ser Arg Pro Phe Gln Pro Trp Asp Lys Leu 
        195                 200                 205             


Glu Gln Tyr Ser Ala Ser Ile Arg Arg Arg Leu Gln Arg Ile Leu Thr 
    210                 215                 220                 


Ala Pro Ile 
225         


<210> 52
<211> 490
<212> PRT
<213> Pan troglodytes

<400> 52
Met Asn Pro Gln Ile Arg Asn Pro Met Glu Trp Met Tyr Gln Arg Thr 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Arg Arg Gly His Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Met Tyr Ser Gln Pro Glu 
    50                  55                  60                  


His His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Ser Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Lys Phe Leu Ala Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Ile Arg His Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg His Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Gln Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Val Arg Ala Ser Ser Leu 
    370                 375                 380                 


Cys Met Val Pro His Arg Pro Pro Pro Pro Pro Gln Ser Pro Gly Pro 
385                 390                 395                 400 


Cys Leu Pro Leu Cys Ser Glu Pro Pro Leu Gly Ser Leu Leu Pro Thr 
                405                 410                 415     


Gly Arg Pro Ala Pro Ser Leu Pro Phe Leu Leu Thr Ala Ser Phe Ser 
            420                 425                 430         


Phe Pro Pro Pro Ala Ser Leu Pro Pro Leu Pro Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly His Leu Pro Val Pro Ser Phe His Ser Leu Thr Ser Cys Ser 
    450                 455                 460                 


Ile Gln Pro Pro Cys Ser Ser Arg Ile Arg Glu Thr Glu Gly Trp Ala 
465                 470                 475                 480 


Ser Val Ser Lys Glu Gly Arg Asp Leu Gly 
                485                 490 


<210> 53
<211> 190
<212> PRT
<213> Homo sapiens

<400> 53
Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 
                165                 170                 175     


Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
            180                 185                 190 


<210> 54
<211> 190
<212> PRT
<213> Gorilla gorilla

<400> 54
Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Glu Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Asn Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Asp 
        115                 120                 125             


Thr Asp Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Lys Ile Met Asp Tyr Lys Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asp Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Tyr 
                165                 170                 175     


Asn Phe Arg Phe Leu Lys Arg Arg Leu Gln Glu Ile Leu Glu 
            180                 185                 190 


<210> 55
<211> 199
<212> PRT
<213> Homo sapiens

<400> 55
Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210> 56
<211> 202
<212> PRT
<213> Macaca mulatta

<400> 56
Met Asp Gly Ser Pro Ala Ser Arg Pro Arg His Leu Met Asp Pro Asn 
1               5                   10                  15      


Thr Phe Thr Phe Asn Phe Asn Asn Asp Leu Ser Val Arg Gly Arg His 
            20                  25                  30          


Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Trp 
        35                  40                  45              


Val Pro Met Asp Glu Arg Arg Gly Phe Leu Cys Asn Lys Ala Lys Asn 
    50                  55                  60                  


Val Pro Cys Gly Asp Tyr Gly Cys His Val Glu Leu Arg Phe Leu Cys 
65                  70                  75                  80  


Glu Val Pro Ser Trp Gln Leu Asp Pro Ala Gln Thr Tyr Arg Val Thr 
                85                  90                  95      


Trp Phe Ile Ser Trp Ser Pro Cys Phe Arg Arg Gly Cys Ala Gly Gln 
            100                 105                 110         


Val Arg Val Phe Leu Gln Glu Asn Lys His Val Arg Leu Arg Ile Phe 
        115                 120                 125             


Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Gln Glu Ala Leu Arg 
    130                 135                 140                 


Thr Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Glu Glu 
145                 150                 155                 160 


Phe Lys His Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe 
                165                 170                 175     


Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg 
            180                 185                 190         


Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
        195                 200         


<210> 57
<211> 185
<212> PRT
<213> Bos sp.

<400> 57
Met Asp Glu Tyr Thr Phe Thr Glu Asn Phe Asn Asn Gln Gly Trp Pro 
1               5                   10                  15      


Ser Lys Thr Tyr Leu Cys Tyr Glu Met Glu Arg Leu Asp Gly Asp Ala 
            20                  25                  30          


Thr Ile Pro Leu Asp Glu Tyr Lys Gly Phe Val Arg Asn Lys Gly Leu 
        35                  40                  45              


Asp Gln Pro Glu Lys Pro Cys His Ala Glu Leu Tyr Phe Leu Gly Lys 
    50                  55                  60                  


Ile His Ser Trp Asn Leu Asp Arg Asn Gln His Tyr Arg Leu Thr Cys 
65                  70                  75                  80  


Phe Ile Ser Trp Ser Pro Cys Tyr Asp Cys Ala Gln Lys Leu Thr Thr 
                85                  90                  95      


Phe Leu Lys Glu Asn His His Ile Ser Leu His Ile Leu Ala Ser Arg 
            100                 105                 110         


Ile Tyr Thr His Asn Arg Phe Gly Cys His Gln Ser Gly Leu Cys Glu 
        115                 120                 125             


Leu Gln Ala Ala Gly Ala Arg Ile Thr Ile Met Thr Phe Glu Asp Phe 
    130                 135                 140                 


Lys His Cys Trp Glu Thr Phe Val Asp His Lys Gly Lys Pro Phe Gln 
145                 150                 155                 160 


Pro Trp Glu Gly Leu Asn Val Lys Ser Gln Ala Leu Cys Thr Glu Leu 
                165                 170                 175     


Gln Ala Ile Leu Lys Thr Gln Gln Asn 
            180                 185 


<210> 58
<211> 200
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met 
            180                 185                 190         


Asp Ile Leu Cys Asp Ala Glu Val 
        195                 200 


<210> 59
<211> 210
<212> PRT
<213> Macaca mulatta

<400> 59
Met Ala Leu Leu Thr Ala Lys Thr Phe Ser Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Val Asn Lys Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly His Leu Lys 
        35                  40                  45              


Asn Lys Lys Lys Asp His Ala Glu Ile Arg Phe Ile Asn Lys Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Pro Ser Cys Ala Gly Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Arg His Leu Asn Leu Arg Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Arg Pro Asn Tyr Gln Glu Gly Leu Leu Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Leu Pro Glu Phe Thr Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Lys Glu Pro Pro Ser Phe Asn Pro Ser 
145                 150                 155                 160 


Glu Lys Leu Glu Glu Leu Asp Lys Asn Ser Gln Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ser Arg Ser Val Asp Val Leu Glu Asn Gly Leu 
            180                 185                 190         


Arg Ser Leu Gln Leu Gly Pro Val Thr Pro Ser Ser Ser Ile Arg Asn 
        195                 200                 205             


Ser Arg 
    210 


<210> 60
<211> 386
<212> PRT
<213> Homo sapiens

<400> 60
Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln 
    50                  55                  60                  


Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu 
65                  70                  75                  80  


Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg 
                85                  90                  95      


Arg Phe Gln Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys 
            100                 105                 110         


Val Val Lys Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu 
        115                 120                 125             


Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 
    130                 135                 140                 


Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 
145                 150                 155                 160 


Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu 
                165                 170                 175     


Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser 
            180                 185                 190         


Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met 
        195                 200                 205             


Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys 
    210                 215                 220                 


Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His 
225                 230                 235                 240 


His Ser Ala Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp 
                245                 250                 255     


Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 
            260                 265                 270         


Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 
        275                 280                 285             


Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 
    290                 295                 300                 


Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys 
305                 310                 315                 320 


Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln 
                325                 330                 335     


Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys 
            340                 345                 350         


Trp Lys Asn Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys 
        355                 360                 365             


Gly Leu Gln Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile 
    370                 375                 380                 


Leu Gln 
385     


<210> 61
<211> 236
<212> PRT
<213> Homo sapiens

<400> 61
Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 
225                 230                 235     


<210> 62
<211> 229
<212> PRT
<213> Mus sp.

<400> 62
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg Tyr Phe Arg Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg His Pro Tyr Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp Val Lys 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Thr Leu Gln Thr Cys His Tyr Gln Arg Ile Pro Pro His Leu Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210> 63
<211> 229
<212> PRT
<213> Rattus sp.

<400> 63
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210> 64
<211> 224
<212> PRT
<213> Homo sapiens

<400> 64
Met Ala Gln Lys Glu Glu Ala Ala Val Ala Thr Glu Ala Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Asp Leu Glu Asn Leu Asp Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Gly Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Ala 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Ile Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Val Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Gln Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 65
<211> 224
<212> PRT
<213> Mus sp.

<400> 65
Met Ala Gln Lys Glu Glu Ala Ala Glu Ala Ala Ala Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Asp Asp Leu Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Asp Leu Pro Pro Phe Glu Ile Val Thr Gly Val Arg Leu Pro 
        35                  40                  45              


Val Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Val Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Ala Gln Ala Thr Gln Gly Tyr Leu Glu Asp Glu His Ala Gly 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Lys Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Leu Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Ser Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Val Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Ile Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 66
<211> 224
<212> PRT
<213> Rattus sp.

<400> 66
Met Ala Gln Lys Glu Glu Ala Ala Glu Ala Ala Ala Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Asp Asp Leu Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Asp Leu Pro Pro Phe Glu Ile Val Thr Gly Val Arg Leu Pro 
        35                  40                  45              


Val Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Thr Gln Gly Tyr Leu Glu Asp Glu His Ala Gly 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Lys Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Leu Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Ser Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Val Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Leu Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 67
<211> 224
<212> PRT
<213> Bos sp.

<400> 67
Met Ala Gln Lys Glu Glu Ala Ala Ala Ala Ala Glu Pro Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Glu Val Glu Asn Leu Glu Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala His Tyr Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Ser Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Thr 
                85                  90                  95      


Asn His Ala Glu Glu Ala Phe Phe Asn Ser Ile Met Pro Thr Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Met Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Val Lys Thr Leu Asn Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Arg Lys Leu Lys Glu Ala Gly Cys Arg Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Ile Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Glu Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210> 68
<211> 208
<212> PRT
<213> Petromyzon marinus

<400> 68
Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Phe Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210> 69
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Phe Asn Tyr Asp Glu Phe Gln His Cys Trp 
145                 150                 155                 160 


Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn Asn 
                165                 170                 175     


Leu Pro Lys Tyr Tyr Ile Leu Leu His Phe Met Leu Gly Glu Ile Leu 
            180                 185                 190         


Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu 
        195                 200                 205             


Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu 
    210                 215                 220                 


Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe 
225                 230                 235                 240 


Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His 
                245                 250                 255     


Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu 
            260                 265                 270         


Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Lys His Val Ser 
    290                 295                 300                 


Leu Cys Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg Cys Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Phe Thr 
                325                 330                 335     


Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly 
            340                 345                 350         


Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu 
        355                 360                 365             


Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380     


<210> 70
<211> 182
<212> PRT
<213> Homo sapiens

<400> 70
Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Trp 
1               5                   10                  15      


Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His Asn 
            20                  25                  30          


Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn Gln 
        35                  40                  45              


Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu Cys 
    50                  55                  60                  


Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp Tyr 
65                  70                  75                  80  


Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln 
                85                  90                  95      


Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys Ile 
            100                 105                 110         


Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys Gln Glu Gly Leu 
        115                 120                 125             


Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Phe Thr Tyr Ser Glu 
    130                 135                 140                 


Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe 
145                 150                 155                 160 


Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser Gly Arg 
                165                 170                 175     


Leu Arg Ala Ile Leu Gln 
            180         


<210> 71
<211> 184
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn Glu Pro Trp Val 
1               5                   10                  15      


Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val Glu Arg Met His 
            20                  25                  30          


Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly Phe Leu Cys Asn 
        35                  40                  45              


Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg His Ala Glu Leu 
    50                  55                  60                  


Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp Leu Asp Gln Asp 
65                  70                  75                  80  


Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala 
                85                  90                  95      


Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His Val Ser Leu Cys 
            100                 105                 110         


Ile Phe Thr Ala Arg Ile Tyr Arg Arg Gln Gly Arg Cys Gln Glu Gly 
        115                 120                 125             


Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser Phe Met Thr Tyr 
    130                 135                 140                 


Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys 
145                 150                 155                 160 


Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Asp Leu Ser 
                165                 170                 175     


Gly Arg Leu Arg Ala Ile Leu Gln 
            180                 


<210> 72
<211> 367
<212> PRT
<213> Homo sapiens

<400> 72
Met Glu Pro Ile Tyr Glu Glu Tyr Leu Ala Asn His Gly Thr Ile Val 
1               5                   10                  15      


Lys Pro Tyr Tyr Trp Leu Ser Phe Ser Leu Asp Cys Ser Asn Cys Pro 
            20                  25                  30          


Tyr His Ile Arg Thr Gly Glu Glu Ala Arg Val Ser Leu Thr Glu Phe 
        35                  40                  45              


Cys Gln Ile Phe Gly Phe Pro Tyr Gly Thr Thr Phe Pro Gln Thr Lys 
    50                  55                  60                  


His Leu Thr Phe Tyr Glu Leu Lys Thr Ser Ser Gly Ser Leu Val Gln 
65                  70                  75                  80  


Lys Gly His Ala Ser Ser Cys Thr Gly Asn Tyr Ile His Pro Glu Ser 
                85                  90                  95      


Met Leu Phe Glu Met Asn Gly Tyr Leu Asp Ser Ala Ile Tyr Asn Asn 
            100                 105                 110         


Asp Ser Ile Arg His Ile Ile Leu Tyr Ser Asn Asn Ser Pro Cys Asn 
        115                 120                 125             


Glu Ala Asn His Cys Cys Ile Ser Lys Met Tyr Asn Phe Leu Ile Thr 
    130                 135                 140                 


Tyr Pro Gly Ile Thr Leu Ser Ile Tyr Phe Ser Gln Leu Tyr His Thr 
145                 150                 155                 160 


Glu Met Asp Phe Pro Ala Ser Ala Trp Asn Arg Glu Ala Leu Arg Ser 
                165                 170                 175     


Leu Ala Ser Leu Trp Pro Arg Val Val Leu Ser Pro Ile Ser Gly Gly 
            180                 185                 190         


Ile Trp His Ser Val Leu His Ser Phe Ile Ser Gly Val Ser Gly Ser 
        195                 200                 205             


His Val Phe Gln Pro Ile Leu Thr Gly Arg Ala Leu Ala Asp Arg His 
    210                 215                 220                 


Asn Ala Tyr Glu Ile Asn Ala Ile Thr Gly Val Lys Pro Tyr Phe Thr 
225                 230                 235                 240 


Asp Val Leu Leu Gln Thr Lys Arg Asn Pro Asn Thr Lys Ala Gln Glu 
                245                 250                 255     


Ala Leu Glu Ser Tyr Pro Leu Asn Asn Ala Phe Pro Gly Gln Phe Phe 
            260                 265                 270         


Gln Met Pro Ser Gly Gln Leu Gln Pro Asn Leu Pro Pro Asp Leu Arg 
        275                 280                 285             


Ala Pro Val Val Phe Val Leu Val Pro Leu Arg Asp Leu Pro Pro Met 
    290                 295                 300                 


His Met Gly Gln Asn Pro Asn Lys Pro Arg Asn Ile Val Arg His Leu 
305                 310                 315                 320 


Asn Met Pro Gln Met Ser Phe Gln Glu Thr Lys Asp Leu Gly Arg Leu 
                325                 330                 335     


Pro Thr Gly Arg Ser Val Glu Ile Val Glu Ile Thr Glu Gln Phe Ala 
            340                 345                 350         


Ser Ser Lys Glu Ala Asp Glu Lys Lys Lys Lys Lys Gly Lys Lys 
        355                 360                 365         


<210> 73
<211> 198
<212> PRT
<213> Mus musculus

<400> 73
Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210> 74
<211> 388
<212> PRT
<213> Rattus norvegicus

<400> 74
Met Glu Pro Leu Tyr Glu Glu Tyr Leu Thr His Ser Gly Thr Ile Val 
1               5                   10                  15      


Lys Pro Tyr Tyr Trp Leu Ser Val Ser Leu Asn Cys Thr Asn Cys Pro 
            20                  25                  30          


Tyr His Ile Arg Thr Gly Glu Glu Ala Arg Val Pro Tyr Thr Glu Phe 
        35                  40                  45              


His Gln Thr Phe Gly Phe Pro Trp Ser Thr Tyr Pro Gln Thr Lys His 
    50                  55                  60                  


Leu Thr Phe Tyr Glu Leu Arg Ser Ser Ser Gly Asn Leu Ile Gln Lys 
65                  70                  75                  80  


Gly Leu Ala Ser Asn Cys Thr Gly Ser His Thr His Pro Glu Ser Met 
                85                  90                  95      


Leu Phe Glu Arg Asp Gly Tyr Leu Asp Ser Leu Ile Phe His Asp Ser 
            100                 105                 110         


Asn Ile Arg His Ile Ile Leu Tyr Ser Asn Asn Ser Pro Cys Asp Glu 
        115                 120                 125             


Ala Asn His Cys Cys Ile Ser Lys Met Tyr Asn Phe Leu Met Asn Tyr 
    130                 135                 140                 


Pro Glu Val Thr Leu Ser Val Phe Phe Ser Gln Leu Tyr His Thr Glu 
145                 150                 155                 160 


Asn Gln Phe Pro Thr Ser Ala Trp Asn Arg Glu Ala Leu Arg Gly Leu 
                165                 170                 175     


Ala Ser Leu Trp Pro Gln Val Thr Leu Ser Ala Ile Ser Gly Gly Ile 
            180                 185                 190         


Trp Gln Ser Ile Leu Glu Thr Phe Val Ser Gly Ile Ser Glu Gly Leu 
        195                 200                 205             


Thr Ala Val Arg Pro Phe Thr Ala Gly Arg Thr Leu Thr Asp Arg Tyr 
    210                 215                 220                 


Asn Ala Tyr Glu Ile Asn Cys Ile Thr Glu Val Lys Pro Tyr Phe Thr 
225                 230                 235                 240 


Asp Ala Leu His Ser Trp Gln Lys Glu Asn Gln Asp Gln Lys Val Trp 
                245                 250                 255     


Ala Ala Ser Glu Asn Gln Pro Leu His Asn Thr Thr Pro Ala Gln Trp 
            260                 265                 270         


Gln Pro Asp Met Ser Gln Asp Cys Arg Thr Pro Ala Val Phe Met Leu 
        275                 280                 285             


Val Pro Tyr Arg Asp Leu Pro Pro Ile His Val Asn Pro Ser Pro Gln 
    290                 295                 300                 


Lys Pro Arg Thr Val Val Arg His Leu Asn Thr Leu Gln Leu Ser Ala 
305                 310                 315                 320 


Ser Lys Val Lys Ala Leu Arg Lys Ser Pro Ser Gly Arg Pro Val Lys 
                325                 330                 335     


Lys Glu Glu Ala Arg Lys Gly Ser Thr Arg Ser Gln Glu Ala Asn Glu 
            340                 345                 350         


Thr Asn Lys Ser Lys Trp Lys Lys Gln Thr Leu Phe Ile Lys Ser Asn 
        355                 360                 365             


Ile Cys His Leu Leu Glu Arg Glu Gln Lys Lys Ile Gly Ile Leu Ser 
    370                 375                 380                 


Ser Trp Ser Val 
385             


<210> 75
<211> 363
<212> PRT
<213> Macaca fascicularis

<400> 75
Met Glu Pro Thr Tyr Glu Glu Tyr Leu Ala Asn His Gly Thr Ile Val 
1               5                   10                  15      


Lys Pro Tyr Tyr Trp Leu Ser Phe Ser Leu Asp Cys Ser Asn Cys Pro 
            20                  25                  30          


Tyr His Ile Arg Thr Gly Glu Glu Ala Arg Val Ser Leu Thr Glu Phe 
        35                  40                  45              


Cys Gln Ile Phe Gly Phe Pro Tyr Gly Thr Thr Tyr Pro Gln Thr Lys 
    50                  55                  60                  


His Leu Thr Phe Tyr Glu Leu Lys Thr Ser Ser Gly Ser Leu Val Gln 
65                  70                  75                  80  


Lys Gly His Ala Ser Ser Cys Thr Gly Asn Tyr Ile His Pro Glu Ser 
                85                  90                  95      


Met Leu Phe Glu Met Asn Gly Tyr Leu Asp Ser Ala Ile Tyr Asn Asn 
            100                 105                 110         


Asp Ser Ile Arg His Ile Ile Leu Tyr Cys Asn Asn Ser Pro Cys Asn 
        115                 120                 125             


Glu Ala Asn His Cys Cys Ile Ser Lys Val Tyr Asn Phe Leu Ile Thr 
    130                 135                 140                 


Tyr Pro Gly Ile Thr Leu Ser Ile Tyr Phe Ser Gln Leu Tyr His Thr 
145                 150                 155                 160 


Glu Met Asp Phe Pro Ala Ser Ala Trp Asn Arg Glu Ala Leu Arg Ser 
                165                 170                 175     


Leu Ala Ser Leu Trp Pro Arg Val Val Leu Ser Pro Ile Ser Gly Gly 
            180                 185                 190         


Ile Trp His Ser Val Leu His Ser Phe Val Ser Gly Val Ser Gly Ser 
        195                 200                 205             


His Val Phe Gln Pro Ile Leu Thr Gly Arg Ala Leu Thr Asp Arg Tyr 
    210                 215                 220                 


Asn Ala Tyr Glu Ile Asn Ala Ile Thr Gly Val Lys Pro Phe Phe Thr 
225                 230                 235                 240 


Asp Val Leu Leu His Thr Lys Arg Asn Pro Asn Thr Lys Ala Gln Met 
                245                 250                 255     


Ala Leu Glu Ser Tyr Pro Leu Asn Asn Ala Phe Pro Gly Gln Ser Phe 
            260                 265                 270         


Gln Met Thr Ser Gly Ile Pro Pro Asp Leu Arg Ala Pro Val Val Phe 
        275                 280                 285             


Val Leu Leu Pro Leu Arg Asp Leu Pro Pro Met His Met Gly Gln Asp 
    290                 295                 300                 


Pro Asn Lys Pro Arg Asn Ile Ile Arg His Leu Asn Met Pro Gln Met 
305                 310                 315                 320 


Ser Phe Gln Glu Thr Lys Asp Leu Glu Arg Leu Pro Thr Arg Arg Ser 
                325                 330                 335     


Val Glu Thr Val Glu Ile Thr Glu Arg Phe Ala Ser Ser Lys Gln Ala 
            340                 345                 350         


Glu Glu Lys Thr Lys Lys Lys Lys Gly Lys Lys 
        355                 360             


<210> 76
<211> 224
<212> PRT
<213> Petromyzon marinus

<400> 76
Met Ala Gly Tyr Glu Cys Val Arg Val Ser Glu Lys Leu Asp Phe Asp 
1               5                   10                  15      


Thr Phe Glu Phe Gln Phe Glu Asn Leu His Tyr Ala Thr Glu Arg His 
            20                  25                  30          


Arg Thr Tyr Val Ile Phe Asp Val Lys Pro Gln Ser Ala Gly Gly Arg 
        35                  40                  45              


Ser Arg Arg Leu Trp Gly Tyr Ile Ile Asn Asn Pro Asn Val Cys His 
    50                  55                  60                  


Ala Glu Leu Ile Leu Met Ser Met Ile Asp Arg His Leu Glu Ser Asn 
65                  70                  75                  80  


Pro Gly Val Tyr Ala Met Thr Trp Tyr Met Ser Trp Ser Pro Cys Ala 
                85                  90                  95      


Asn Cys Ser Ser Lys Leu Asn Pro Trp Leu Lys Asn Leu Leu Glu Glu 
            100                 105                 110         


Gln Gly His Thr Leu Thr Met His Phe Ser Arg Ile Tyr Asp Arg Asp 
        115                 120                 125             


Arg Glu Gly Asp His Arg Gly Leu Arg Gly Leu Lys His Val Ser Asn 
    130                 135                 140                 


Ser Phe Arg Met Gly Val Val Gly Arg Ala Glu Val Lys Glu Cys Leu 
145                 150                 155                 160 


Ala Glu Tyr Val Glu Ala Ser Arg Arg Thr Leu Thr Trp Leu Asp Thr 
                165                 170                 175     


Thr Glu Ser Met Ala Ala Lys Met Arg Arg Lys Leu Phe Cys Ile Leu 
            180                 185                 190         


Val Arg Cys Ala Gly Met Arg Glu Ser Gly Ile Pro Leu His Leu Phe 
        195                 200                 205             


Thr Leu Gln Thr Pro Leu Leu Ser Gly Arg Val Val Trp Trp Arg Val 
    210                 215                 220                 


<210> 77
<211> 331
<212> PRT
<213> Petromyzon marinus

<400> 77
Met Glu Leu Arg Glu Val Val Asp Cys Ala Leu Ala Ser Cys Val Arg 
1               5                   10                  15      


His Glu Pro Leu Ser Arg Val Ala Phe Leu Arg Cys Phe Ala Ala Pro 
            20                  25                  30          


Ser Gln Lys Pro Arg Gly Thr Val Ile Leu Phe Tyr Val Glu Gly Ala 
        35                  40                  45              


Gly Arg Gly Val Thr Gly Gly His Ala Val Asn Tyr Asn Lys Gln Gly 
    50                  55                  60                  


Thr Ser Ile His Ala Glu Val Leu Leu Leu Ser Ala Val Arg Ala Ala 
65                  70                  75                  80  


Leu Leu Arg Arg Arg Arg Cys Glu Asp Gly Glu Glu Ala Thr Arg Gly 
                85                  90                  95      


Cys Thr Leu His Cys Tyr Ser Thr Tyr Ser Pro Cys Arg Asp Cys Val 
            100                 105                 110         


Glu Tyr Ile Gln Glu Phe Gly Ala Ser Thr Gly Val Arg Val Val Ile 
        115                 120                 125             


His Cys Cys Arg Leu Tyr Glu Leu Asp Val Asn Arg Arg Arg Ser Glu 
    130                 135                 140                 


Ala Glu Gly Val Leu Arg Ser Leu Ser Arg Leu Gly Arg Asp Phe Arg 
145                 150                 155                 160 


Leu Met Gly Pro Arg Asp Ala Ile Ala Leu Leu Leu Gly Gly Arg Leu 
                165                 170                 175     


Ala Asn Thr Ala Asp Gly Glu Ser Gly Ala Ser Gly Asn Ala Trp Val 
            180                 185                 190         


Thr Glu Thr Asn Val Val Glu Pro Leu Val Asp Met Thr Gly Phe Gly 
        195                 200                 205             


Asp Glu Asp Leu His Ala Gln Val Gln Arg Asn Lys Gln Ile Arg Glu 
    210                 215                 220                 


Ala Tyr Ala Asn Tyr Ala Ser Ala Val Ser Leu Met Leu Gly Glu Leu 
225                 230                 235                 240 


His Val Asp Pro Asp Lys Phe Pro Phe Leu Ala Glu Phe Leu Ala Gln 
                245                 250                 255     


Thr Ser Val Glu Pro Ser Gly Thr Pro Arg Glu Thr Arg Gly Arg Pro 
            260                 265                 270         


Arg Gly Ala Ser Ser Arg Gly Pro Glu Ile Gly Arg Gln Arg Pro Ala 
        275                 280                 285             


Asp Phe Glu Arg Ala Leu Gly Ala Tyr Gly Leu Phe Leu His Pro Arg 
    290                 295                 300                 


Ile Val Ser Arg Glu Ala Asp Arg Glu Glu Ile Lys Arg Asp Leu Ile 
305                 310                 315                 320 


Val Val Met Arg Lys His Asn Tyr Gln Gly Pro 
                325                 330     


<210> 78
<211> 209
<212> PRT
<213> Petromyzon marinus

<400> 78
Met Ala Gly Asp Glu Asn Val Arg Val Ser Glu Lys Leu Asp Phe Asp 
1               5                   10                  15      


Thr Phe Glu Phe Gln Phe Glu Asn Leu His Tyr Ala Thr Glu Arg His 
            20                  25                  30          


Arg Thr Tyr Val Ile Phe Asp Val Lys Pro Gln Ser Ala Gly Gly Arg 
        35                  40                  45              


Ser Arg Arg Leu Trp Gly Tyr Ile Ile Asn Asn Pro Asn Val Cys His 
    50                  55                  60                  


Ala Glu Leu Ile Leu Met Ser Met Ile Asp Arg His Leu Glu Ser Asn 
65                  70                  75                  80  


Pro Gly Val Tyr Ala Met Thr Trp Tyr Met Ser Trp Ser Pro Cys Ala 
                85                  90                  95      


Asn Cys Ser Ser Lys Leu Asn Pro Trp Leu Lys Asn Leu Leu Glu Glu 
            100                 105                 110         


Gln Gly His Thr Leu Met Met His Phe Ser Arg Ile Tyr Asp Arg Asp 
        115                 120                 125             


Arg Glu Gly Asp His Arg Gly Leu Arg Gly Leu Lys His Val Ser Asn 
    130                 135                 140                 


Ser Phe Arg Met Gly Val Val Gly Arg Ala Glu Val Lys Glu Cys Leu 
145                 150                 155                 160 


Ala Glu Tyr Val Glu Ala Ser Arg Arg Thr Leu Thr Trp Leu Asp Thr 
                165                 170                 175     


Thr Glu Ser Met Ala Ala Lys Met Arg Arg Lys Leu Phe Cys Ile Leu 
            180                 185                 190         


Val Arg Cys Ala Gly Met Arg Glu Ser Gly Met Pro Leu His Leu Phe 
        195                 200                 205             


Thr 
    


<210> 79
<211> 158
<212> PRT
<213> Saccharomyces cerevisiae

<400> 79
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      


Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          


Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              


Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  


Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      


Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         


Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             


Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 


Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             


<210> 80
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu 
            180                 185                 190         


Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro 
        195                 200                 205             


Pro His Ile Leu Trp Ala Thr Gly Leu Lys 
    210                 215             


<210> 81
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln His Tyr Gln Arg Leu Pro 
        195                 200                 205             


Pro His Ile Leu Trp Ala Thr Gly Leu Lys 
    210                 215             


<210> 82
<211> 429
<212> PRT
<213> Mus sp.

<400> 82
Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210> 83
<211> 167
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210> 84
<211> 1378
<212> PRT
<213> Lactobacillus fermentum

<400> 84
Met Lys Glu Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile Lys Gly Lys 
            20                  25                  30          


Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala Ala Glu 
        35                  40                  45              


Arg Arg Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys Trp 
    50                  55                  60                  


Arg Leu His Tyr Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val 
65                  70                  75                  80  


Asp Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu 
                85                  90                  95      


Asp Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp 
            100                 105                 110         


Leu Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg 
        115                 120                 125             


Asp Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile 
    130                 135                 140                 


Tyr Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu 
145                 150                 155                 160 


Arg Glu Val Tyr Leu Ala Val His His Ile Val Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp 
            180                 185                 190         


Phe Asp Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln 
        195                 200                 205             


Asn Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile 
    210                 215                 220                 


Gly Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp Arg Gln Lys 
225                 230                 235                 240 


Ala Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr 
                245                 250                 255     


Lys Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly 
            260                 265                 270         


Tyr Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp 
        275                 280                 285             


Lys Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe 
    290                 295                 300                 


Arg Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr 
305                 310                 315                 320 


Ser Leu Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met 
                325                 330                 335     


Ser Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln 
            340                 345                 350         


Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg 
        355                 360                 365             


Lys Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys 
    370                 375                 380                 


Glu Lys Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys 
385                 390                 395                 400 


Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe 
                405                 410                 415     


Leu Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met 
            420                 425                 430         


His Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr 
        435                 440                 445             


Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His 
    450                 455                 460                 


Gln Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly 
                485                 490                 495     


Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro 
            500                 505                 510         


Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe 
        515                 520                 525             


Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val 
    530                 535                 540                 


Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu 
545                 550                 555                 560 


Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys 
                565                 570                 575     


Gln Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Ala 
            580                 585                 590         


Gly Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys 
        595                 600                 605             


Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu 
    610                 615                 620                 


Ala Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp 
625                 630                 635                 640 


Asn Arg Tyr Gln Met Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val 
                645                 650                 655     


Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp 
            660                 665                 670         


Leu Thr Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly 
        675                 680                 685             


Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn 
    690                 695                 700                 


Gly Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Met 
705                 710                 715                 720 


Gln Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn 
                725                 730                 735     


Gln Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Arg Val Glu 
            740                 745                 750         


Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
        755                 760                 765             


Trp Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn 
    770                 775                 780                 


Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys 
785                 790                 795                 800 


Gly Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys Leu Phe Glu 
                805                 810                 815     


Asp Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr Glu Glu Leu 
            820                 825                 830         


Glu Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Phe Tyr Phe Thr Gln 
        835                 840                 845             


Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe Asp Glu Ile 
    850                 855                 860                 


Ser Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Val Lys 
865                 870                 875                 880 


Asp Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala Glu Asn Asn 
                885                 890                 895     


Lys Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala Lys Met Lys 
            900                 905                 910         


Pro Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr Gln Arg Lys 
        915                 920                 925             


Phe Glu Asn Leu Thr Met Asp Val Asp Gln Thr Ile Lys Tyr Arg Ser 
    930                 935                 940                 


Leu Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln Val Ile Lys 
945                 950                 955                 960 


Leu Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala Gly Thr Asp 
                965                 970                 975     


Ile Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg Glu Glu Phe 
            980                 985                 990         


Asp Leu Pro Lys Val Arg Glu Val  Asn Asp Tyr His His  Ala Val Asp 
        995                 1000                 1005             


Ala Tyr  Leu Thr Thr Phe Ala  Gly Gln Tyr Leu Asn  Arg Arg Tyr 
    1010                 1015                 1020             


Pro Lys  Leu Arg Ser Phe Phe  Val Tyr Gly Glu Tyr  Met Lys Phe 
    1025                 1030                 1035             


Lys His  Gly Ser Asp Leu Lys  Leu Arg Asn Phe Asn  Phe Phe His 
    1040                 1045                 1050             


Glu Leu  Met Glu Gly Asp Lys  Ser Gln Gly Lys Val  Val Asp Gln 
    1055                 1060                 1065             


Gln Thr  Gly Glu Leu Ile Thr  Thr Arg Asp Glu Val  Ala Asp Tyr 
    1070                 1075                 1080             


Phe Asp  Trp Val Ile Asn Leu  Lys Val Met Leu Ile  Ser Asn Glu 
    1085                 1090                 1095             


Thr Tyr  Glu Glu Thr Gly Lys  Tyr Phe Asp Ala Ser  His Glu Ser 
    1100                 1105                 1110             


Ser Ser  Leu Tyr Leu Lys Asn  Gln Asn Lys Lys Ser  Lys Leu Val 
    1115                 1120                 1125             


Val Pro  Leu Lys Asn Lys Leu  Gln Pro Glu Tyr Tyr  Gly Ala Tyr 
    1130                 1135                 1140             


Thr Gly  Ile Thr Gln Gly Tyr  Met Val Ile Leu Lys  Leu Leu Asp 
    1145                 1150                 1155             


Lys Lys  Gly Gly Phe Gly Val  Tyr Arg Ile Pro Arg  Tyr Ala Ala 
    1160                 1165                 1170             


Asp Ile  Leu Asn Lys Cys His  Asp Glu Val Ala Tyr  Arg Asn Lys 
    1175                 1180                 1185             


Ile Ala  Glu Ile Ile Ser Ser  Asp Pro Arg Ala Pro  Lys Ser Phe 
    1190                 1195                 1200             


Glu Val  Val Val Pro Arg Val  Leu Lys Gly Thr Phe  Leu Val Asp 
    1205                 1210                 1215             


Gly Glu  Glu Lys Phe Ile Leu  Ser Ser Tyr Arg Tyr  Lys Val Asn 
    1220                 1225                 1230             


Ala Thr  Gln Leu Ile Leu Pro  Val Ser Asp Ile Lys  Leu Ile Gln 
    1235                 1240                 1245             


Asp Asn  Phe Lys Ala Leu Lys  Lys Leu Asn Val Glu  Met Gln Thr 
    1250                 1255                 1260             


Lys Lys  Leu Ile Glu Ile Tyr  Asp Asn Ile Leu Arg  Gln Val Asp 
    1265                 1270                 1275             


Lys Tyr  Tyr Lys Leu Tyr Asp  Ile Asn Lys Phe Arg  Ala Lys Leu 
    1280                 1285                 1290             


His Asp  Gly Arg Ser Lys Phe  Val Glu Leu Asp Asp  Phe Gly Gln 
    1295                 1300                 1305             


Asp Ala  Ser Lys Glu Lys Val  Ile Ile Lys Ile Leu  Arg Gly Leu 
    1310                 1315                 1320             


His Phe  Gly Ser Asp Leu Gln  Asn Leu Lys Glu Ile  Gly Phe Gly 
    1325                 1330                 1335             


Thr Thr  Pro Leu Gly Gln Phe  Gln Val Ser Glu Ala  Gly Ile Arg 
    1340                 1345                 1350             


Leu Ser  Asn Thr Ala Phe Ile  Ile Phe Lys Ser Pro  Thr Gly Leu 
    1355                 1360                 1365             


Phe Asn  Arg Lys Leu Tyr Leu  Lys Asn Leu 
    1370                 1375             


<210> 85
<211> 1432
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Pro Lys Lys Lys Arg Lys Val Gly Lys Glu Tyr His Ile Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Ser Ser Ile Gly Trp Ala Val Thr Asp Ser Gln Phe 
            20                  25                  30          


Lys Leu Met Arg Ile Lys Gly Lys Thr Ala Ile Gly Val Arg Leu Phe 
        35                  40                  45              


Glu Glu Gly Lys Thr Ala Ala Glu Arg Arg Thr Phe Arg Thr Thr Arg 
    50                  55                  60                  


Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu His Tyr Leu Asp Glu Ile 
65                  70                  75                  80  


Phe Ala Pro His Leu Gln Glu Val Asp Glu Asn Phe Leu Arg Arg Leu 
                85                  90                  95      


Lys Gln Ser Asn Ile His Pro Glu Asp Pro Ala Lys Asn Gln Ala Phe 
            100                 105                 110         


Ile Gly Lys Leu Leu Phe Pro Asp Leu Leu Lys Lys Asn Glu Arg Gly 
        115                 120                 125             


Tyr Pro Thr Leu Ile Lys Met Arg Asp Glu Leu Pro Val Glu Gln Arg 
    130                 135                 140                 


Ala His Tyr Pro Val Thr Asn Ile Tyr Lys Leu Arg Glu Ala Met Ile 
145                 150                 155                 160 


Asn Glu Asp Arg Gln Phe Asp Leu Arg Glu Val Tyr Leu Ala Val His 
                165                 170                 175     


His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Asn Ala Ser Val Asp 
            180                 185                 190         


Lys Phe Lys Val Gly Arg Ile Asp Phe Asp Lys Ser Phe Asn Val Leu 
        195                 200                 205             


Asn Glu Ala Tyr Glu Glu Leu Gln Asn Gly Glu Gly Ser Phe Thr Ile 
    210                 215                 220                 


Glu Pro Ser Lys Val Glu Lys Ile Gly Gln Leu Leu Leu Asp Thr Lys 
225                 230                 235                 240 


Met Arg Lys Leu Asp Arg Gln Lys Ala Val Ala Lys Leu Leu Glu Val 
                245                 250                 255     


Lys Val Ala Asp Lys Glu Glu Thr Lys Arg Asn Lys Gln Ile Ala Thr 
            260                 265                 270         


Ala Met Ser Lys Leu Val Leu Gly Tyr Lys Ala Asp Phe Ala Thr Val 
        275                 280                 285             


Ala Met Ala Asn Gly Asn Glu Trp Lys Ile Asp Leu Ser Ser Glu Thr 
    290                 295                 300                 


Ser Glu Asp Glu Ile Glu Lys Phe Arg Glu Glu Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Asn Asp Ile Leu Thr Glu Ile Thr Ser Leu Phe Ser Gln Ile Met Leu 
                325                 330                 335     


Asn Glu Ile Val Pro Asn Gly Met Ser Ile Ser Glu Ser Met Met Asp 
            340                 345                 350         


Arg Tyr Trp Thr His Glu Arg Gln Leu Ala Glu Val Lys Glu Tyr Leu 
        355                 360                 365             


Ala Thr Gln Pro Ala Ser Ala Arg Lys Glu Phe Asp Gln Val Tyr Asn 
    370                 375                 380                 


Lys Tyr Ile Gly Gln Ala Pro Lys Glu Lys Gly Phe Asp Leu Glu Lys 
385                 390                 395                 400 


Gly Leu Lys Lys Ile Leu Ser Lys Lys Glu Asn Trp Lys Glu Ile Asp 
                405                 410                 415     


Glu Leu Leu Lys Ala Gly Asp Phe Leu Pro Lys Gln Arg Thr Ser Ala 
            420                 425                 430         


Asn Gly Val Ile Pro His Gln Met His Gln Gln Glu Leu Asp Arg Ile 
        435                 440                 445             


Ile Glu Lys Gln Ala Lys Tyr Tyr Pro Trp Leu Ala Thr Glu Asn Pro 
    450                 455                 460                 


Ala Thr Gly Glu Arg Asp Arg His Gln Ala Lys Tyr Glu Leu Asp Gln 
465                 470                 475                 480 


Leu Val Ser Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro 
                485                 490                 495     


Glu Val Gln Lys Ala Thr Ser Gly Ala Lys Phe Ala Trp Ala Lys Arg 
            500                 505                 510         


Lys Glu Asp Gly Glu Ile Thr Pro Trp Asn Leu Trp Asp Lys Ile Asp 
        515                 520                 525             


Arg Ala Glu Ser Ala Glu Ala Phe Ile Lys Arg Met Thr Val Lys Asp 
    530                 535                 540                 


Thr Tyr Leu Leu Asn Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr 
545                 550                 555                 560 


Gln Lys Tyr Asn Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Gly 
                565                 570                 575     


Arg Arg Leu Ser Val Gly Ile Lys Gln Asp Ile Tyr Thr Glu Leu Phe 
            580                 585                 590         


Lys Lys Lys Lys Thr Val Lys Ala Gly Asp Val Ala Ser Leu Val Met 
        595                 600                 605             


Ala Lys Thr Arg Gly Val Asn Lys Pro Ser Val Glu Gly Leu Ser Asp 
    610                 615                 620                 


Pro Lys Lys Phe Asn Ser Asn Leu Ala Thr Tyr Leu Asp Leu Lys Ser 
625                 630                 635                 640 


Ile Val Gly Asp Lys Val Asp Asp Asn Arg Tyr Gln Met Asp Leu Glu 
                645                 650                 655     


Asn Ile Ile Glu Trp Arg Ser Val Phe Glu Asp Gly Glu Ile Phe Ala 
            660                 665                 670         


Asp Lys Leu Thr Glu Val Glu Trp Leu Thr Asp Glu Gln Arg Ser Ala 
        675                 680                 685             


Leu Val Lys Lys Arg Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu 
    690                 695                 700                 


Leu Thr Gly Ile Val Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met 
705                 710                 715                 720 


Trp Asn Thr Asp Gln Asn Phe Met Gln Ile Val Asn Gln Pro Val Phe 
                725                 730                 735     


Lys Glu Gln Ile Asp Gln Leu Asn Gln Lys Ala Ile Thr Asn Asp Gly 
            740                 745                 750         


Met Thr Leu Arg Glu Arg Val Glu Ser Val Leu Asp Asp Ala Tyr Thr 
        755                 760                 765             


Ser Pro Gln Asn Lys Lys Ala Ile Trp Gln Val Val Arg Val Val Glu 
    770                 775                 780                 


Asp Ile Val Lys Ala Val Gly Asn Ala Pro Lys Ser Ile Ser Ile Glu 
785                 790                 795                 800 


Phe Ala Arg Asn Glu Gly Asn Lys Gly Glu Ile Thr Arg Ser Arg Arg 
                805                 810                 815     


Thr Gln Leu Gln Lys Leu Phe Glu Asp Gln Ala His Glu Leu Val Lys 
            820                 825                 830         


Asp Thr Ser Leu Thr Glu Glu Leu Glu Lys Ala Pro Asp Leu Ser Asp 
        835                 840                 845             


Arg Tyr Tyr Phe Tyr Phe Thr Gln Gly Gly Lys Asp Met Tyr Thr Gly 
    850                 855                 860                 


Asp Pro Ile Asn Phe Asp Glu Ile Ser Thr Lys Tyr Asp Ile Asp His 
865                 870                 875                 880 


Ile Leu Pro Gln Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Arg Val 
                885                 890                 895     


Leu Val Ser Arg Ala Glu Asn Asn Lys Lys Ser Asp Arg Val Pro Ala 
            900                 905                 910         


Lys Leu Tyr Ala Ala Lys Met Lys Pro Tyr Trp Asn Gln Leu Leu Lys 
        915                 920                 925             


Gln Gly Leu Ile Thr Gln Arg Lys Phe Glu Asn Leu Thr Met Asp Val 
    930                 935                 940                 


Asp Gln Thr Ile Lys Tyr Arg Ser Leu Gly Phe Val Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Val Ile Lys Leu Thr Ala Asn Ile Leu Gly Ser 
                965                 970                 975     


Met Tyr Gln Glu Ala Gly Thr Asp Ile Ile Glu Thr Arg Ala Gly Leu 
            980                 985                 990         


Thr Lys Gln Leu Arg Glu Glu Phe  Asp Leu Pro Lys Val  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Val  Asp Ala Tyr Leu Thr  Thr Phe Ala 
    1010                 1015                 1020             


Gly Gln  Tyr Leu Asn Arg Arg  Tyr Pro Lys Leu Arg  Ser Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Glu Tyr Met Lys  Phe Lys His Gly Ser  Asp Leu Lys 
    1040                 1045                 1050             


Leu Arg  Asn Phe Asn Phe Phe  His Glu Leu Met Glu  Gly Asp Lys 
    1055                 1060                 1065             


Ser Gln  Gly Lys Val Val Asp  Gln Gln Thr Gly Glu  Leu Ile Thr 
    1070                 1075                 1080             


Thr Arg  Asp Glu Val Ala Asp  Tyr Phe Asp Trp Val  Ile Asn Leu 
    1085                 1090                 1095             


Lys Val  Met Leu Ile Ser Asn  Glu Thr Tyr Glu Glu  Thr Gly Lys 
    1100                 1105                 1110             


Tyr Phe  Asp Ala Ser His Glu  Ser Ser Ser Leu Tyr  Leu Lys Asn 
    1115                 1120                 1125             


Gln Asn  Lys Lys Ser Lys Leu  Val Val Pro Leu Lys  Asn Lys Leu 
    1130                 1135                 1140             


Gln Pro  Glu Tyr Tyr Gly Ala  Tyr Thr Gly Ile Thr  Gln Gly Tyr 
    1145                 1150                 1155             


Met Val  Ile Leu Lys Leu Leu  Asp Lys Lys Gly Gly  Phe Gly Val 
    1160                 1165                 1170             


Tyr Arg  Ile Pro Arg Tyr Ala  Ala Asp Ile Leu Asn  Lys Cys His 
    1175                 1180                 1185             


Asp Glu  Val Ala Tyr Arg Asn  Lys Ile Ala Glu Ile  Ile Ser Ser 
    1190                 1195                 1200             


Asp Pro  Arg Ala Pro Lys Ser  Phe Glu Val Val Val  Pro Arg Val 
    1205                 1210                 1215             


Leu Lys  Gly Thr Phe Leu Val  Asp Gly Glu Glu Lys  Phe Ile Leu 
    1220                 1225                 1230             


Ser Ser  Tyr Arg Tyr Lys Val  Asn Ala Thr Gln Leu  Ile Leu Pro 
    1235                 1240                 1245             


Val Ser  Asp Ile Lys Leu Ile  Gln Asp Asn Phe Lys  Ala Leu Lys 
    1250                 1255                 1260             


Lys Leu  Asn Val Glu Met Gln  Thr Lys Lys Leu Ile  Glu Ile Tyr 
    1265                 1270                 1275             


Asp Asn  Ile Leu Arg Gln Val  Asp Lys Tyr Tyr Lys  Leu Tyr Asp 
    1280                 1285                 1290             


Ile Asn  Lys Phe Arg Ala Lys  Leu His Asp Gly Arg  Ser Lys Phe 
    1295                 1300                 1305             


Val Glu  Leu Asp Asp Phe Gly  Gln Asp Ala Ser Lys  Glu Lys Val 
    1310                 1315                 1320             


Ile Ile  Lys Ile Leu Arg Gly  Leu His Phe Gly Ser  Asp Leu Gln 
    1325                 1330                 1335             


Asn Leu  Lys Glu Ile Gly Phe  Gly Thr Thr Pro Leu  Gly Gln Phe 
    1340                 1345                 1350             


Gln Val  Ser Glu Ala Gly Ile  Arg Leu Ser Asn Thr  Ala Phe Ile 
    1355                 1360                 1365             


Ile Phe  Lys Ser Pro Thr Gly  Leu Phe Asn Arg Lys  Leu Tyr Leu 
    1370                 1375                 1380             


Lys Asn  Leu Gly Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1385                 1390                 1395             


Ala Lys  Lys Lys Lys Gly Ser  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1400                 1405                 1410             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val 
    1415                 1420                 1425             


Pro Asp  Tyr Ala 
    1430         


<210> 86
<211> 1359
<212> PRT
<213> Peptoniphilus sp.

<400> 86
Met Glu Lys Lys Thr Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Val Lys Asp Asp Leu Glu Leu Val Lys Lys 
            20                  25                  30          


Arg Met Lys Val Leu Gly Asn Thr Glu Thr Asn Tyr Ile Lys Lys Asn 
        35                  40                  45              


Leu Trp Gly Ser Leu Leu Phe Glu Ser Gly Gln Thr Ala Lys Asp Arg 
    50                  55                  60                  


Arg Leu Lys Arg Val Ala Arg Arg Arg Tyr Glu Arg Arg Arg Asn Arg 
65                  70                  75                  80  


Leu Thr Glu Leu Gln Lys Ile Phe Ala Pro Ala Ile Asp Glu Val Asp 
                85                  90                  95      


Glu Asn Phe Phe Phe Arg Leu Asn Glu Ser Phe Leu Val Pro Glu Asp 
            100                 105                 110         


Lys Ala Phe Ser Lys Asn Pro Ile Phe Gly Thr Leu Gly Glu Asp Lys 
        115                 120                 125             


Thr Tyr Tyr Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln His Leu 
    130                 135                 140                 


Ala Asp Ser Glu Glu Lys Ala Asp Val Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
                165                 170                 175     


Asp Thr Glu His Ile Ala Ile Asn Glu Asn Leu Glu Gln Phe Phe Glu 
            180                 185                 190         


Ser Tyr Asn Ala Leu Phe Ser Glu Glu Pro Ile Glu Leu Arg Lys Glu 
        195                 200                 205             


Glu Leu Ile Ala Ile Glu Asn Ile Leu Arg Glu Lys Asn Ser Arg Thr 
    210                 215                 220                 


Val Lys Glu Lys Arg Ile Thr Ser Phe Leu Lys Asp Ile Gly Arg Ala 
225                 230                 235                 240 


Asn Lys Gln Ser Pro Met Met Ala Phe Ile Thr Leu Ile Val Gly Lys 
                245                 250                 255     


Lys Ala Lys Phe Lys Ala Ala Phe Asn Leu Glu Glu Glu Ile Ser Leu 
            260                 265                 270         


Asn Leu Thr Asp Asp Ser Tyr Asp Glu Asn Leu Glu Ile Leu Leu Asn 
        275                 280                 285             


Thr Ile Gly Ser Asp Phe Ala Asp Leu Phe Asp His Ala Gln Arg Val 
    290                 295                 300                 


Tyr Asn Ala Val Glu Leu Ala Gly Ile Leu Ser Gly Asp Val Lys Asn 
305                 310                 315                 320 


Thr His Ala Lys Leu Ser Ala Gln Met Val Ala Met Tyr Glu Arg His 
                325                 330                 335     


Lys Glu Gln Leu Lys Glu Tyr Lys Ser Phe Ile Lys Ala Asn Leu Pro 
            340                 345                 350         


Asp Gln Tyr Asp Met Thr Phe Val Ala Pro Lys Asp Ala Gln Lys Lys 
        355                 360                 365             


Asp Leu Lys Gly Tyr Ala Gly Tyr Ile Asp Gly Asn Met Ser Gln Asp 
    370                 375                 380                 


Ser Phe Tyr Lys Phe Val Lys Asp Gln Leu Lys Glu Val Pro Gly Ser 
385                 390                 395                 400 


Glu Lys Phe Leu Asp Ser Ile Glu Lys Glu Asp Phe Leu Arg Lys Gln 
                405                 410                 415     


Arg Ser Phe Tyr Asn Gly Val Ile Pro Asn Gln Val His Leu Ala Glu 
            420                 425                 430         


Met Glu Ala Ile Leu Asp Arg Gln Glu Asn Tyr Tyr Pro Trp Leu Lys 
        435                 440                 445             


Glu Asn Arg Glu Lys Ile Ile Ser Leu Leu Thr Phe Arg Ile Pro Tyr 
    450                 455                 460                 


Tyr Val Gly Pro Leu Ala Asp Gly Gln Ser Glu Phe Ala Trp Leu Glu 
465                 470                 475                 480 


Arg Lys Ser Asp Glu Lys Ile Lys Pro Trp Asn Phe Ser Asp Val Val 
                485                 490                 495     


Asp Leu Asp Arg Ser Ala Glu Lys Phe Ile Glu Gln Leu Ile Gly Arg 
            500                 505                 510         


Asp Thr Tyr Leu Pro Asp Glu Tyr Val Leu Pro Lys Lys Ser Leu Ile 
        515                 520                 525             


Tyr Gln Lys Tyr Met Val Phe Asn Glu Leu Thr Lys Ile Ala Tyr Leu 
    530                 535                 540                 


Asp Glu Arg Gln Lys Arg Met Asn Leu Ser Ser Val Glu Lys Lys Glu 
545                 550                 555                 560 


Ile Phe Glu Thr Leu Phe Lys Lys Arg Ser Lys Val Thr Glu Lys Gln 
                565                 570                 575     


Leu Val Lys Phe Phe Glu Asn Tyr Leu Gln Ile Asp Asn Pro Thr Ile 
            580                 585                 590         


Phe Gly Ile Glu Asp Ala Phe Asn Ala Asp Tyr Ser Thr Tyr Val Glu 
        595                 600                 605             


Leu Ala Lys Val Pro Gly Met Lys Ser Met Met Asp Asp Pro Asp Asn 
    610                 615                 620                 


Glu Asp Leu Met Glu Glu Ile Val Lys Ile Leu Thr Val Phe Glu Asp 
625                 630                 635                 640 


Arg Lys Met Arg Arg Lys Gln Leu Glu Lys Tyr Lys Glu Arg Leu Ser 
                645                 650                 655     


Pro Glu Gln Ile Lys Glu Leu Ala Lys Lys His Tyr Thr Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Lys Lys Leu Leu Val Gly Ile Arg Asp Lys Glu Thr Gln 
        675                 680                 685             


Lys Thr Ile Leu Asp Tyr Leu Val Glu Asp Asp Asn His Ser Gly Gly 
    690                 695                 700                 


Arg Gln His Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Asp Arg 
705                 710                 715                 720 


Leu Ser Phe Lys Lys Thr Ile Ala Glu Leu Gln Met Ile Asp Pro Ser 
                725                 730                 735     


Ala Asp Leu Tyr Ala Gln Val Gln Glu Ile Ala Gly Ser Pro Ala Ile 
            740                 745                 750         


Lys Lys Gly Ile Leu Leu Gly Leu Lys Ile Val Asp Glu Ile Ile Arg 
        755                 760                 765             


Val Met Gly Glu Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Ala Arg Gly Lys Ala Leu Ser Lys Arg Arg Glu Ala 
785                 790                 795                 800 


Lys Ile Lys Glu Gly Leu Ala Ala Leu Gly Ser Ser Leu Leu Lys Glu 
                805                 810                 815     


Asn Leu Pro Gly Asn Ala Asp Leu Ser Gln Arg Lys Ile Tyr Leu Tyr 
            820                 825                 830         


Tyr Thr Gln Asn Gly Lys Asp Ile Tyr Leu Asp Glu Pro Leu Asp Phe 
        835                 840                 845             


Asp Arg Leu Ser Gln Tyr Asp Glu Asp His Ile Ile Pro Gln Ser Phe 
    850                 855                 860                 


Thr Val Asp Asn Ser Leu Asp Asn Leu Val Leu Thr Asn Ser Ser Gln 
865                 870                 875                 880 


Asn Arg Gly Asn Lys Lys Asp Asp Val Pro Ser Leu Glu Val Val Asn 
                885                 890                 895     


Arg Gln Leu Ala Tyr Trp Arg Ser Leu Lys Asp Ala Gly Leu Met Thr 
            900                 905                 910         


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Met Arg Gly Gly Leu Thr 
        915                 920                 925             


Asp Lys Asp Arg Glu Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg 
    930                 935                 940                 


Gln Ile Thr Lys Asn Val Ala Lys Leu Leu Asp Met Arg Leu Asn Asp 
945                 950                 955                 960 


Lys Lys Asp Glu Ala Gly Asn Lys Ile Arg Glu Thr Asn Ile Val Leu 
                965                 970                 975     


Leu Lys Ser Ala Met Ala Ser Glu Phe Arg Lys Met Phe Arg Leu Tyr 
            980                 985                 990         


Lys Val Arg Glu Leu Asn Asp Tyr  His His Ala His Asp  Ala Tyr Leu 
        995                 1000                 1005             


Asn Ala  Ala Ile Ala Ile Asn  Leu Leu Ala Leu Tyr  Pro Tyr Met 
    1010                 1015                 1020             


Ala Asp  Asp Phe Val Tyr Gly  Glu Phe Arg Tyr Lys  Lys Lys Pro 
    1025                 1030                 1035             


Gln Ala  Glu Lys Ala Thr Tyr  Glu Lys Leu Arg Gln  Trp Asn Leu 
    1040                 1045                 1050             


Ile Lys  Arg Phe Gly Glu Lys  Gln Leu Phe Thr Pro  Asp His Glu 
    1055                 1060                 1065             


Asp Cys  Trp Asn Lys Glu Arg  Asp Ile Lys Thr Ile  Lys Lys Val 
    1070                 1075                 1080             


Met Gly  Tyr Arg Gln Val Asn  Val Val Lys Lys Ala  Glu Glu Arg 
    1085                 1090                 1095             


Thr Gly  Met Leu Phe Lys Glu  Thr Ile Asn Gly Lys  Thr Asn Lys 
    1100                 1105                 1110             


Gly Ser  Arg Ile Pro Ile Lys  Lys Asp Leu Asp Pro  Ser Lys Tyr 
    1115                 1120                 1125             


Gly Gly  Tyr Ile Glu Glu Lys  Met Ala Tyr Tyr Ala  Val Ile Ser 
    1130                 1135                 1140             


Tyr Glu  Asp Lys Lys Lys Lys  Pro Gly Lys Thr Ile  Val Gly Ile 
    1145                 1150                 1155             


Ser Ile  Met Asp Lys Lys Glu  Phe Glu Tyr Asp Ser  Ile Ser Tyr 
    1160                 1165                 1170             


Leu Gly  Lys Leu Gly Phe Ser  Asn Pro Val Val Gln  Ile Ile Leu 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Ile Ala  Tyr Pro Asp Gly Arg  Arg Arg Tyr 
    1190                 1195                 1200             


Ile Thr  Gly Ala Thr Lys Thr  Thr Lys Gly Lys Val  Glu Leu Gln 
    1205                 1210                 1215             


Lys Ala  Asn Gln Ile Ala Met  Glu Gln Asp Leu Val  Asn Phe Ile 
    1220                 1225                 1230             


Tyr His  Leu Lys Asn Tyr Asp  Glu Ile Ser His Pro  Glu Ser Tyr 
    1235                 1240                 1245             


Ala Phe  Val Gln Ser His Thr  Asp Tyr Phe Asp Arg  Leu Phe Asp 
    1250                 1255                 1260             


Ser Ile  Glu His Tyr Thr Arg  Arg Phe Leu Asp Ala  Glu Thr Asn 
    1265                 1270                 1275             


Ile Asn  Arg Leu Arg Arg Ile  Tyr Glu Glu Glu Lys  Lys Lys Asp 
    1280                 1285                 1290             


Pro Val  Asp Ile Glu Ala Leu  Val Ala Ser Phe Ile  Glu Leu Leu 
    1295                 1300                 1305             


Lys Leu  Thr Ser Ala Gly Ala  Pro Ala Asp Phe Ile  Phe Met Gly 
    1310                 1315                 1320             


Glu Ala  Ile Ser Arg Arg Arg  Tyr Asn Ser Met Thr  Gly Leu Phe 
    1325                 1330                 1335             


Asp Gly  Gln Val Ile Tyr Gln  Ser Leu Thr Gly Leu  Tyr Glu Thr 
    1340                 1345                 1350             


Arg Met  Arg Phe Glu Asp 
    1355                 


<210> 87
<211> 1413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Pro Lys Lys Lys Arg Lys Val Gly Glu Lys Lys Thr Asn Tyr Thr 
1               5                   10                  15      


Ile Gly Leu Asp Ile Gly Thr Asp Ser Val Gly Trp Ala Val Val Lys 
            20                  25                  30          


Asp Asp Leu Glu Leu Val Lys Lys Arg Met Lys Val Leu Gly Asn Thr 
        35                  40                  45              


Glu Thr Asn Tyr Ile Lys Lys Asn Leu Trp Gly Ser Leu Leu Phe Glu 
    50                  55                  60                  


Ser Gly Gln Thr Ala Lys Asp Arg Arg Leu Lys Arg Val Ala Arg Arg 
65                  70                  75                  80  


Arg Tyr Glu Arg Arg Arg Asn Arg Leu Thr Glu Leu Gln Lys Ile Phe 
                85                  90                  95      


Ala Pro Ala Ile Asp Glu Val Asp Glu Asn Phe Phe Phe Arg Leu Asn 
            100                 105                 110         


Glu Ser Phe Leu Val Pro Glu Asp Lys Ala Phe Ser Lys Asn Pro Ile 
        115                 120                 125             


Phe Gly Thr Leu Gly Glu Asp Lys Thr Tyr Tyr Lys Thr Tyr Pro Thr 
    130                 135                 140                 


Ile Tyr His Leu Arg Gln His Leu Ala Asp Ser Glu Glu Lys Ala Asp 
145                 150                 155                 160 


Val Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly 
                165                 170                 175     


His Phe Leu Ile Glu Gly Lys Leu Asp Thr Glu His Ile Ala Ile Asn 
            180                 185                 190         


Glu Asn Leu Glu Gln Phe Phe Glu Ser Tyr Asn Ala Leu Phe Ser Glu 
        195                 200                 205             


Glu Pro Ile Glu Leu Arg Lys Glu Glu Leu Ile Ala Ile Glu Asn Ile 
    210                 215                 220                 


Leu Arg Glu Lys Asn Ser Arg Thr Val Lys Glu Lys Arg Ile Thr Ser 
225                 230                 235                 240 


Phe Leu Lys Asp Ile Gly Arg Ala Asn Lys Gln Ser Pro Met Met Ala 
                245                 250                 255     


Phe Ile Thr Leu Ile Val Gly Lys Lys Ala Lys Phe Lys Ala Ala Phe 
            260                 265                 270         


Asn Leu Glu Glu Glu Ile Ser Leu Asn Leu Thr Asp Asp Ser Tyr Asp 
        275                 280                 285             


Glu Asn Leu Glu Ile Leu Leu Asn Thr Ile Gly Ser Asp Phe Ala Asp 
    290                 295                 300                 


Leu Phe Asp His Ala Gln Arg Val Tyr Asn Ala Val Glu Leu Ala Gly 
305                 310                 315                 320 


Ile Leu Ser Gly Asp Val Lys Asn Thr His Ala Lys Leu Ser Ala Gln 
                325                 330                 335     


Met Val Ala Met Tyr Glu Arg His Lys Glu Gln Leu Lys Glu Tyr Lys 
            340                 345                 350         


Ser Phe Ile Lys Ala Asn Leu Pro Asp Gln Tyr Asp Met Thr Phe Val 
        355                 360                 365             


Ala Pro Lys Asp Ala Gln Lys Lys Asp Leu Lys Gly Tyr Ala Gly Tyr 
    370                 375                 380                 


Ile Asp Gly Asn Met Ser Gln Asp Ser Phe Tyr Lys Phe Val Lys Asp 
385                 390                 395                 400 


Gln Leu Lys Glu Val Pro Gly Ser Glu Lys Phe Leu Asp Ser Ile Glu 
                405                 410                 415     


Lys Glu Asp Phe Leu Arg Lys Gln Arg Ser Phe Tyr Asn Gly Val Ile 
            420                 425                 430         


Pro Asn Gln Val His Leu Ala Glu Met Glu Ala Ile Leu Asp Arg Gln 
        435                 440                 445             


Glu Asn Tyr Tyr Pro Trp Leu Lys Glu Asn Arg Glu Lys Ile Ile Ser 
    450                 455                 460                 


Leu Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Asp Gly 
465                 470                 475                 480 


Gln Ser Glu Phe Ala Trp Leu Glu Arg Lys Ser Asp Glu Lys Ile Lys 
                485                 490                 495     


Pro Trp Asn Phe Ser Asp Val Val Asp Leu Asp Arg Ser Ala Glu Lys 
            500                 505                 510         


Phe Ile Glu Gln Leu Ile Gly Arg Asp Thr Tyr Leu Pro Asp Glu Tyr 
        515                 520                 525             


Val Leu Pro Lys Lys Ser Leu Ile Tyr Gln Lys Tyr Met Val Phe Asn 
    530                 535                 540                 


Glu Leu Thr Lys Ile Ala Tyr Leu Asp Glu Arg Gln Lys Arg Met Asn 
545                 550                 555                 560 


Leu Ser Ser Val Glu Lys Lys Glu Ile Phe Glu Thr Leu Phe Lys Lys 
                565                 570                 575     


Arg Ser Lys Val Thr Glu Lys Gln Leu Val Lys Phe Phe Glu Asn Tyr 
            580                 585                 590         


Leu Gln Ile Asp Asn Pro Thr Ile Phe Gly Ile Glu Asp Ala Phe Asn 
        595                 600                 605             


Ala Asp Tyr Ser Thr Tyr Val Glu Leu Ala Lys Val Pro Gly Met Lys 
    610                 615                 620                 


Ser Met Met Asp Asp Pro Asp Asn Glu Asp Leu Met Glu Glu Ile Val 
625                 630                 635                 640 


Lys Ile Leu Thr Val Phe Glu Asp Arg Lys Met Arg Arg Lys Gln Leu 
                645                 650                 655     


Glu Lys Tyr Lys Glu Arg Leu Ser Pro Glu Gln Ile Lys Glu Leu Ala 
            660                 665                 670         


Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Val 
        675                 680                 685             


Gly Ile Arg Asp Lys Glu Thr Gln Lys Thr Ile Leu Asp Tyr Leu Val 
    690                 695                 700                 


Glu Asp Asp Asn His Ser Gly Gly Arg Gln His Leu Asn Arg Asn Leu 
705                 710                 715                 720 


Met Gln Leu Ile Asn Asp Asp Arg Leu Ser Phe Lys Lys Thr Ile Ala 
                725                 730                 735     


Glu Leu Gln Met Ile Asp Pro Ser Ala Asp Leu Tyr Ala Gln Val Gln 
            740                 745                 750         


Glu Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Leu Gly Leu 
        755                 760                 765             


Lys Ile Val Asp Glu Ile Ile Arg Val Met Gly Glu Lys Pro Glu Asn 
    770                 775                 780                 


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Arg Gly Lys 
785                 790                 795                 800 


Ala Leu Ser Lys Arg Arg Glu Ala Lys Ile Lys Glu Gly Leu Ala Ala 
                805                 810                 815     


Leu Gly Ser Ser Leu Leu Lys Glu Asn Leu Pro Gly Asn Ala Asp Leu 
            820                 825                 830         


Ser Gln Arg Lys Ile Tyr Leu Tyr Tyr Thr Gln Asn Gly Lys Asp Ile 
        835                 840                 845             


Tyr Leu Asp Glu Pro Leu Asp Phe Asp Arg Leu Ser Gln Tyr Asp Glu 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Phe Thr Val Asp Asn Ser Leu Asp Asn 
865                 870                 875                 880 


Leu Val Leu Thr Asn Ser Ser Gln Asn Arg Gly Asn Lys Lys Asp Asp 
                885                 890                 895     


Val Pro Ser Leu Glu Val Val Asn Arg Gln Leu Ala Tyr Trp Arg Ser 
            900                 905                 910         


Leu Lys Asp Ala Gly Leu Met Thr Gln Arg Lys Phe Asp Asn Leu Thr 
        915                 920                 925             


Lys Ala Met Arg Gly Gly Leu Thr Asp Lys Asp Arg Glu Arg Phe Ile 
    930                 935                 940                 


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Lys 
945                 950                 955                 960 


Leu Leu Asp Met Arg Leu Asn Asp Lys Lys Asp Glu Ala Gly Asn Lys 
                965                 970                 975     


Ile Arg Glu Thr Asn Ile Val Leu Leu Lys Ser Ala Met Ala Ser Glu 
            980                 985                 990         


Phe Arg Lys Met Phe Arg Leu Tyr  Lys Val Arg Glu Leu  Asn Asp Tyr 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Ala Ile  Ala Ile Asn 
    1010                 1015                 1020             


Leu Leu  Ala Leu Tyr Pro Tyr  Met Ala Asp Asp Phe  Val Tyr Gly 
    1025                 1030                 1035             


Glu Phe  Arg Tyr Lys Lys Lys  Pro Gln Ala Glu Lys  Ala Thr Tyr 
    1040                 1045                 1050             


Glu Lys  Leu Arg Gln Trp Asn  Leu Ile Lys Arg Phe  Gly Glu Lys 
    1055                 1060                 1065             


Gln Leu  Phe Thr Pro Asp His  Glu Asp Cys Trp Asn  Lys Glu Arg 
    1070                 1075                 1080             


Asp Ile  Lys Thr Ile Lys Lys  Val Met Gly Tyr Arg  Gln Val Asn 
    1085                 1090                 1095             


Val Val  Lys Lys Ala Glu Glu  Arg Thr Gly Met Leu  Phe Lys Glu 
    1100                 1105                 1110             


Thr Ile  Asn Gly Lys Thr Asn  Lys Gly Ser Arg Ile  Pro Ile Lys 
    1115                 1120                 1125             


Lys Asp  Leu Asp Pro Ser Lys  Tyr Gly Gly Tyr Ile  Glu Glu Lys 
    1130                 1135                 1140             


Met Ala  Tyr Tyr Ala Val Ile  Ser Tyr Glu Asp Lys  Lys Lys Lys 
    1145                 1150                 1155             


Pro Gly  Lys Thr Ile Val Gly  Ile Ser Ile Met Asp  Lys Lys Glu 
    1160                 1165                 1170             


Phe Glu  Tyr Asp Ser Ile Ser  Tyr Leu Gly Lys Leu  Gly Phe Ser 
    1175                 1180                 1185             


Asn Pro  Val Val Gln Ile Ile  Leu Lys Asn Tyr Ser  Leu Ile Ala 
    1190                 1195                 1200             


Tyr Pro  Asp Gly Arg Arg Arg  Tyr Ile Thr Gly Ala  Thr Lys Thr 
    1205                 1210                 1215             


Thr Lys  Gly Lys Val Glu Leu  Gln Lys Ala Asn Gln  Ile Ala Met 
    1220                 1225                 1230             


Glu Gln  Asp Leu Val Asn Phe  Ile Tyr His Leu Lys  Asn Tyr Asp 
    1235                 1240                 1245             


Glu Ile  Ser His Pro Glu Ser  Tyr Ala Phe Val Gln  Ser His Thr 
    1250                 1255                 1260             


Asp Tyr  Phe Asp Arg Leu Phe  Asp Ser Ile Glu His  Tyr Thr Arg 
    1265                 1270                 1275             


Arg Phe  Leu Asp Ala Glu Thr  Asn Ile Asn Arg Leu  Arg Arg Ile 
    1280                 1285                 1290             


Tyr Glu  Glu Glu Lys Lys Lys  Asp Pro Val Asp Ile  Glu Ala Leu 
    1295                 1300                 1305             


Val Ala  Ser Phe Ile Glu Leu  Leu Lys Leu Thr Ser  Ala Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Ile Phe Met  Gly Glu Ala Ile Ser  Arg Arg Arg 
    1325                 1330                 1335             


Tyr Asn  Ser Met Thr Gly Leu  Phe Asp Gly Gln Val  Ile Tyr Gln 
    1340                 1345                 1350             


Ser Leu  Thr Gly Leu Tyr Glu  Thr Arg Met Arg Phe  Glu Asp Gly 
    1355                 1360                 1365             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1370                 1375                 1380             


Lys Gly  Ser Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr 
    1385                 1390                 1395             


Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1400                 1405                 1410             


<210> 88
<211> 1628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Lys Glu Tyr 
        195                 200                 205             


His Ile Gly Leu Ala Ile Gly Thr Ser Ser Ile Gly Trp Ala Val Thr 
    210                 215                 220                 


Asp Ser Gln Phe Lys Leu Met Arg Ile Lys Gly Lys Thr Ala Ile Gly 
225                 230                 235                 240 


Val Arg Leu Phe Glu Glu Gly Lys Thr Ala Ala Glu Arg Arg Thr Phe 
                245                 250                 255     


Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu His Tyr 
            260                 265                 270         


Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val Asp Glu Asn Phe 
        275                 280                 285             


Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu Asp Pro Ala Lys 
    290                 295                 300                 


Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp Leu Leu Lys Lys 
305                 310                 315                 320 


Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg Asp Glu Leu Pro 
                325                 330                 335     


Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile Tyr Lys Leu Arg 
            340                 345                 350         


Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu Arg Glu Val Tyr 
        355                 360                 365             


Leu Ala Val His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Asn 
    370                 375                 380                 


Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp Phe Asp Lys Ser 
385                 390                 395                 400 


Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln Asn Gly Glu Gly 
                405                 410                 415     


Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile Gly Gln Leu Leu 
            420                 425                 430         


Leu Asp Thr Lys Met Arg Lys Leu Asp Arg Gln Lys Ala Val Ala Lys 
        435                 440                 445             


Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr Lys Arg Asn Lys 
    450                 455                 460                 


Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly Tyr Lys Ala Asp 
465                 470                 475                 480 


Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp Lys Ile Asp Leu 
                485                 490                 495     


Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe Arg Glu Glu Leu 
            500                 505                 510         


Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr Ser Leu Phe Ser 
        515                 520                 525             


Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met Ser Ile Ser Glu 
    530                 535                 540                 


Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln Leu Ala Glu Val 
545                 550                 555                 560 


Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg Lys Glu Phe Asp 
                565                 570                 575     


Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys Glu Lys Gly Phe 
            580                 585                 590         


Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys Lys Glu Asn Trp 
        595                 600                 605             


Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe Leu Pro Lys Gln 
    610                 615                 620                 


Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met His Gln Gln Glu 
625                 630                 635                 640 


Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr Pro Trp Leu Ala 
                645                 650                 655     


Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His Gln Ala Lys Tyr 
            660                 665                 670         


Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
        675                 680                 685             


Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly Ala Lys Phe Ala 
    690                 695                 700                 


Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro Trp Asn Leu Trp 
705                 710                 715                 720 


Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe Ile Lys Arg Met 
                725                 730                 735     


Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val Leu Pro Ala Asn 
            740                 745                 750         


Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu Leu Asn Asn Val 
        755                 760                 765             


Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys Gln Asp Ile Tyr 
    770                 775                 780                 


Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Ala Gly Asp Val Ala 
785                 790                 795                 800 


Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys Pro Ser Val Glu 
                805                 810                 815     


Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu Ala Thr Tyr Leu 
            820                 825                 830         


Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp Asn Arg Tyr Gln 
        835                 840                 845             


Met Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val Phe Glu Asp Gly 
    850                 855                 860                 


Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp Leu Thr Asp Glu 
865                 870                 875                 880 


Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly Trp Gly Arg Leu 
                885                 890                 895     


Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn Gly Gln Arg Ile 
            900                 905                 910         


Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Met Gln Ile Val Asn 
        915                 920                 925             


Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn Gln Lys Ala Ile 
    930                 935                 940                 


Thr Asn Asp Gly Met Thr Leu Arg Glu Arg Val Glu Ser Val Leu Asp 
945                 950                 955                 960 


Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Trp Gln Val Val 
                965                 970                 975     


Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn Ala Pro Lys Ser 
            980                 985                 990         


Ile Ser Ile Glu Phe Ala Arg Asn  Glu Gly Asn Lys Gly  Glu Ile Thr 
        995                 1000                 1005             


Arg Ser  Arg Arg Thr Gln Leu  Gln Lys Leu Phe Glu  Asp Gln Ala 
    1010                 1015                 1020             


His Glu  Leu Val Lys Asp Thr  Ser Leu Thr Glu Glu  Leu Glu Lys 
    1025                 1030                 1035             


Ala Pro  Asp Leu Ser Asp Arg  Tyr Tyr Phe Tyr Phe  Thr Gln Gly 
    1040                 1045                 1050             


Gly Lys  Asp Met Tyr Thr Gly  Asp Pro Ile Asn Phe  Asp Glu Ile 
    1055                 1060                 1065             


Ser Thr  Lys Tyr Asp Ile Asp  His Ile Leu Pro Gln  Ser Phe Val 
    1070                 1075                 1080             


Lys Asp  Asp Ser Leu Asp Asn  Arg Val Leu Val Ser  Arg Ala Glu 
    1085                 1090                 1095             


Asn Asn  Lys Lys Ser Asp Arg  Val Pro Ala Lys Leu  Tyr Ala Ala 
    1100                 1105                 1110             


Lys Met  Lys Pro Tyr Trp Asn  Gln Leu Leu Lys Gln  Gly Leu Ile 
    1115                 1120                 1125             


Thr Gln  Arg Lys Phe Glu Asn  Leu Thr Met Asp Val  Asp Gln Thr 
    1130                 1135                 1140             


Ile Lys  Tyr Arg Ser Leu Gly  Phe Val Lys Arg Gln  Leu Val Glu 
    1145                 1150                 1155             


Thr Arg  Gln Val Ile Lys Leu  Thr Ala Asn Ile Leu  Gly Ser Met 
    1160                 1165                 1170             


Tyr Gln  Glu Ala Gly Thr Asp  Ile Ile Glu Thr Arg  Ala Gly Leu 
    1175                 1180                 1185             


Thr Lys  Gln Leu Arg Glu Glu  Phe Asp Leu Pro Lys  Val Arg Glu 
    1190                 1195                 1200             


Val Asn  Asp Tyr His His Ala  Val Asp Ala Tyr Leu  Thr Thr Phe 
    1205                 1210                 1215             


Ala Gly  Gln Tyr Leu Asn Arg  Arg Tyr Pro Lys Leu  Arg Ser Phe 
    1220                 1225                 1230             


Phe Val  Tyr Gly Glu Tyr Met  Lys Phe Lys His Gly  Ser Asp Leu 
    1235                 1240                 1245             


Lys Leu  Arg Asn Phe Asn Phe  Phe His Glu Leu Met  Glu Gly Asp 
    1250                 1255                 1260             


Lys Ser  Gln Gly Lys Val Val  Asp Gln Gln Thr Gly  Glu Leu Ile 
    1265                 1270                 1275             


Thr Thr  Arg Asp Glu Val Ala  Asp Tyr Phe Asp Trp  Val Ile Asn 
    1280                 1285                 1290             


Leu Lys  Val Met Leu Ile Ser  Asn Glu Thr Tyr Glu  Glu Thr Gly 
    1295                 1300                 1305             


Lys Tyr  Phe Asp Ala Ser His  Glu Ser Ser Ser Leu  Tyr Leu Lys 
    1310                 1315                 1320             


Asn Gln  Asn Lys Lys Ser Lys  Leu Val Val Pro Leu  Lys Asn Lys 
    1325                 1330                 1335             


Leu Gln  Pro Glu Tyr Tyr Gly  Ala Tyr Thr Gly Ile  Thr Gln Gly 
    1340                 1345                 1350             


Tyr Met  Val Ile Leu Lys Leu  Leu Asp Lys Lys Gly  Gly Phe Gly 
    1355                 1360                 1365             


Val Tyr  Arg Ile Pro Arg Tyr  Ala Ala Asp Ile Leu  Asn Lys Cys 
    1370                 1375                 1380             


His Asp  Glu Val Ala Tyr Arg  Asn Lys Ile Ala Glu  Ile Ile Ser 
    1385                 1390                 1395             


Ser Asp  Pro Arg Ala Pro Lys  Ser Phe Glu Val Val  Val Pro Arg 
    1400                 1405                 1410             


Val Leu  Lys Gly Thr Phe Leu  Val Asp Gly Glu Glu  Lys Phe Ile 
    1415                 1420                 1425             


Leu Ser  Ser Tyr Arg Tyr Lys  Val Asn Ala Thr Gln  Leu Ile Leu 
    1430                 1435                 1440             


Pro Val  Ser Asp Ile Lys Leu  Ile Gln Asp Asn Phe  Lys Ala Leu 
    1445                 1450                 1455             


Lys Lys  Leu Asn Val Glu Met  Gln Thr Lys Lys Leu  Ile Glu Ile 
    1460                 1465                 1470             


Tyr Asp  Asn Ile Leu Arg Gln  Val Asp Lys Tyr Tyr  Lys Leu Tyr 
    1475                 1480                 1485             


Asp Ile  Asn Lys Phe Arg Ala  Lys Leu His Asp Gly  Arg Ser Lys 
    1490                 1495                 1500             


Phe Val  Glu Leu Asp Asp Phe  Gly Gln Asp Ala Ser  Lys Glu Lys 
    1505                 1510                 1515             


Val Ile  Ile Lys Ile Leu Arg  Gly Leu His Phe Gly  Ser Asp Leu 
    1520                 1525                 1530             


Gln Asn  Leu Lys Glu Ile Gly  Phe Gly Thr Thr Pro  Leu Gly Gln 
    1535                 1540                 1545             


Phe Gln  Val Ser Glu Ala Gly  Ile Arg Leu Ser Asn  Thr Ala Phe 
    1550                 1555                 1560             


Ile Ile  Phe Lys Ser Pro Thr  Gly Leu Phe Asn Arg  Lys Leu Tyr 
    1565                 1570                 1575             


Leu Lys  Asn Leu Gly Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    1580                 1585                 1590             


Gln Ala  Lys Lys Lys Lys Gly  Ser Tyr Pro Tyr Asp  Val Pro Asp 
    1595                 1600                 1605             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1610                 1615                 1620             


Val Pro  Asp Tyr Ala 
    1625             


<210> 89
<211> 1624
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Pro Lys Lys Lys Arg Lys Val Gly Lys Glu Tyr His Ile Gly Leu 
1               5                   10                  15      


Ala Ile Gly Thr Ser Ser Ile Gly Trp Ala Val Thr Asp Ser Gln Phe 
            20                  25                  30          


Lys Leu Met Arg Ile Lys Gly Lys Thr Ala Ile Gly Val Arg Leu Phe 
        35                  40                  45              


Glu Glu Gly Lys Thr Ala Ala Glu Arg Arg Thr Phe Arg Thr Thr Arg 
    50                  55                  60                  


Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu His Tyr Leu Asp Glu Ile 
65                  70                  75                  80  


Phe Ala Pro His Leu Gln Glu Val Asp Glu Asn Phe Leu Arg Arg Leu 
                85                  90                  95      


Lys Gln Ser Asn Ile His Pro Glu Asp Pro Ala Lys Asn Gln Ala Phe 
            100                 105                 110         


Ile Gly Lys Leu Leu Phe Pro Asp Leu Leu Lys Lys Asn Glu Arg Gly 
        115                 120                 125             


Tyr Pro Thr Leu Ile Lys Met Arg Asp Glu Leu Pro Val Glu Gln Arg 
    130                 135                 140                 


Ala His Tyr Pro Val Thr Asn Ile Tyr Lys Leu Arg Glu Ala Met Ile 
145                 150                 155                 160 


Asn Glu Asp Arg Gln Phe Asp Leu Arg Glu Val Tyr Leu Ala Val His 
                165                 170                 175     


His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Asn Ala Ser Val Asp 
            180                 185                 190         


Lys Phe Lys Val Gly Arg Ile Asp Phe Asp Lys Ser Phe Asn Val Leu 
        195                 200                 205             


Asn Glu Ala Tyr Glu Glu Leu Gln Asn Gly Glu Gly Ser Phe Thr Ile 
    210                 215                 220                 


Glu Pro Ser Lys Val Glu Lys Ile Gly Gln Leu Leu Leu Asp Thr Lys 
225                 230                 235                 240 


Met Arg Lys Leu Asp Arg Gln Lys Ala Val Ala Lys Leu Leu Glu Val 
                245                 250                 255     


Lys Val Ala Asp Lys Glu Glu Thr Lys Arg Asn Lys Gln Ile Ala Thr 
            260                 265                 270         


Ala Met Ser Lys Leu Val Leu Gly Tyr Lys Ala Asp Phe Ala Thr Val 
        275                 280                 285             


Ala Met Ala Asn Gly Asn Glu Trp Lys Ile Asp Leu Ser Ser Glu Thr 
    290                 295                 300                 


Ser Glu Asp Glu Ile Glu Lys Phe Arg Glu Glu Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Asn Asp Ile Leu Thr Glu Ile Thr Ser Leu Phe Ser Gln Ile Met Leu 
                325                 330                 335     


Asn Glu Ile Val Pro Asn Gly Met Ser Ile Ser Glu Ser Met Met Asp 
            340                 345                 350         


Arg Tyr Trp Thr His Glu Arg Gln Leu Ala Glu Val Lys Glu Tyr Leu 
        355                 360                 365             


Ala Thr Gln Pro Ala Ser Ala Arg Lys Glu Phe Asp Gln Val Tyr Asn 
    370                 375                 380                 


Lys Tyr Ile Gly Gln Ala Pro Lys Glu Lys Gly Phe Asp Leu Glu Lys 
385                 390                 395                 400 


Gly Leu Lys Lys Ile Leu Ser Lys Lys Glu Asn Trp Lys Glu Ile Asp 
                405                 410                 415     


Glu Leu Leu Lys Ala Gly Asp Phe Leu Pro Lys Gln Arg Thr Ser Ala 
            420                 425                 430         


Asn Gly Val Ile Pro His Gln Met His Gln Gln Glu Leu Asp Arg Ile 
        435                 440                 445             


Ile Glu Lys Gln Ala Lys Tyr Tyr Pro Trp Leu Ala Thr Glu Asn Pro 
    450                 455                 460                 


Ala Thr Gly Glu Arg Asp Arg His Gln Ala Lys Tyr Glu Leu Asp Gln 
465                 470                 475                 480 


Leu Val Ser Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro 
                485                 490                 495     


Glu Val Gln Lys Ala Thr Ser Gly Ala Lys Phe Ala Trp Ala Lys Arg 
            500                 505                 510         


Lys Glu Asp Gly Glu Ile Thr Pro Trp Asn Leu Trp Asp Lys Ile Asp 
        515                 520                 525             


Arg Ala Glu Ser Ala Glu Ala Phe Ile Lys Arg Met Thr Val Lys Asp 
    530                 535                 540                 


Thr Tyr Leu Leu Asn Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr 
545                 550                 555                 560 


Gln Lys Tyr Asn Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Gly 
                565                 570                 575     


Arg Arg Leu Ser Val Gly Ile Lys Gln Asp Ile Tyr Thr Glu Leu Phe 
            580                 585                 590         


Lys Lys Lys Lys Thr Val Lys Ala Gly Asp Val Ala Ser Leu Val Met 
        595                 600                 605             


Ala Lys Thr Arg Gly Val Asn Lys Pro Ser Val Glu Gly Leu Ser Asp 
    610                 615                 620                 


Pro Lys Lys Phe Asn Ser Asn Leu Ala Thr Tyr Leu Asp Leu Lys Ser 
625                 630                 635                 640 


Ile Val Gly Asp Lys Val Asp Asp Asn Arg Tyr Gln Met Asp Leu Glu 
                645                 650                 655     


Asn Ile Ile Glu Trp Arg Ser Val Phe Glu Asp Gly Glu Ile Phe Ala 
            660                 665                 670         


Asp Lys Leu Thr Glu Val Glu Trp Leu Thr Asp Glu Gln Arg Ser Ala 
        675                 680                 685             


Leu Val Lys Lys Arg Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu 
    690                 695                 700                 


Leu Thr Gly Ile Val Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met 
705                 710                 715                 720 


Trp Asn Thr Asp Gln Asn Phe Met Gln Ile Val Asn Gln Pro Val Phe 
                725                 730                 735     


Lys Glu Gln Ile Asp Gln Leu Asn Gln Lys Ala Ile Thr Asn Asp Gly 
            740                 745                 750         


Met Thr Leu Arg Glu Arg Val Glu Ser Val Leu Asp Asp Ala Tyr Thr 
        755                 760                 765             


Ser Pro Gln Asn Lys Lys Ala Ile Trp Gln Val Val Arg Val Val Glu 
    770                 775                 780                 


Asp Ile Val Lys Ala Val Gly Asn Ala Pro Lys Ser Ile Ser Ile Glu 
785                 790                 795                 800 


Phe Ala Arg Asn Glu Gly Asn Lys Gly Glu Ile Thr Arg Ser Arg Arg 
                805                 810                 815     


Thr Gln Leu Gln Lys Leu Phe Glu Asp Gln Ala His Glu Leu Val Lys 
            820                 825                 830         


Asp Thr Ser Leu Thr Glu Glu Leu Glu Lys Ala Pro Asp Leu Ser Asp 
        835                 840                 845             


Arg Tyr Tyr Phe Tyr Phe Thr Gln Gly Gly Lys Asp Met Tyr Thr Gly 
    850                 855                 860                 


Asp Pro Ile Asn Phe Asp Glu Ile Ser Thr Lys Tyr Asp Ile Asp His 
865                 870                 875                 880 


Ile Leu Pro Gln Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Arg Val 
                885                 890                 895     


Leu Val Ser Arg Ala Glu Asn Asn Lys Lys Ser Asp Arg Val Pro Ala 
            900                 905                 910         


Lys Leu Tyr Ala Ala Lys Met Lys Pro Tyr Trp Asn Gln Leu Leu Lys 
        915                 920                 925             


Gln Gly Leu Ile Thr Gln Arg Lys Phe Glu Asn Leu Thr Met Asp Val 
    930                 935                 940                 


Asp Gln Thr Ile Lys Tyr Arg Ser Leu Gly Phe Val Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Val Ile Lys Leu Thr Ala Asn Ile Leu Gly Ser 
                965                 970                 975     


Met Tyr Gln Glu Ala Gly Thr Asp Ile Ile Glu Thr Arg Ala Gly Leu 
            980                 985                 990         


Thr Lys Gln Leu Arg Glu Glu Phe  Asp Leu Pro Lys Val  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Val  Asp Ala Tyr Leu Thr  Thr Phe Ala 
    1010                 1015                 1020             


Gly Gln  Tyr Leu Asn Arg Arg  Tyr Pro Lys Leu Arg  Ser Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Glu Tyr Met Lys  Phe Lys His Gly Ser  Asp Leu Lys 
    1040                 1045                 1050             


Leu Arg  Asn Phe Asn Phe Phe  His Glu Leu Met Glu  Gly Asp Lys 
    1055                 1060                 1065             


Ser Gln  Gly Lys Val Val Asp  Gln Gln Thr Gly Glu  Leu Ile Thr 
    1070                 1075                 1080             


Thr Arg  Asp Glu Val Ala Asp  Tyr Phe Asp Trp Val  Ile Asn Leu 
    1085                 1090                 1095             


Lys Val  Met Leu Ile Ser Asn  Glu Thr Tyr Glu Glu  Thr Gly Lys 
    1100                 1105                 1110             


Tyr Phe  Asp Ala Ser His Glu  Ser Ser Ser Leu Tyr  Leu Lys Asn 
    1115                 1120                 1125             


Gln Asn  Lys Lys Ser Lys Leu  Val Val Pro Leu Lys  Asn Lys Leu 
    1130                 1135                 1140             


Gln Pro  Glu Tyr Tyr Gly Ala  Tyr Thr Gly Ile Thr  Gln Gly Tyr 
    1145                 1150                 1155             


Met Val  Ile Leu Lys Leu Leu  Asp Lys Lys Gly Gly  Phe Gly Val 
    1160                 1165                 1170             


Tyr Arg  Ile Pro Arg Tyr Ala  Ala Asp Ile Leu Asn  Lys Cys His 
    1175                 1180                 1185             


Asp Glu  Val Ala Tyr Arg Asn  Lys Ile Ala Glu Ile  Ile Ser Ser 
    1190                 1195                 1200             


Asp Pro  Arg Ala Pro Lys Ser  Phe Glu Val Val Val  Pro Arg Val 
    1205                 1210                 1215             


Leu Lys  Gly Thr Phe Leu Val  Asp Gly Glu Glu Lys  Phe Ile Leu 
    1220                 1225                 1230             


Ser Ser  Tyr Arg Tyr Lys Val  Asn Ala Thr Gln Leu  Ile Leu Pro 
    1235                 1240                 1245             


Val Ser  Asp Ile Lys Leu Ile  Gln Asp Asn Phe Lys  Ala Leu Lys 
    1250                 1255                 1260             


Lys Leu  Asn Val Glu Met Gln  Thr Lys Lys Leu Ile  Glu Ile Tyr 
    1265                 1270                 1275             


Asp Asn  Ile Leu Arg Gln Val  Asp Lys Tyr Tyr Lys  Leu Tyr Asp 
    1280                 1285                 1290             


Ile Asn  Lys Phe Arg Ala Lys  Leu His Asp Gly Arg  Ser Lys Phe 
    1295                 1300                 1305             


Val Glu  Leu Asp Asp Phe Gly  Gln Asp Ala Ser Lys  Glu Lys Val 
    1310                 1315                 1320             


Ile Ile  Lys Ile Leu Arg Gly  Leu His Phe Gly Ser  Asp Leu Gln 
    1325                 1330                 1335             


Asn Leu  Lys Glu Ile Gly Phe  Gly Thr Thr Pro Leu  Gly Gln Phe 
    1340                 1345                 1350             


Gln Val  Ser Glu Ala Gly Ile  Arg Leu Ser Asn Thr  Ala Phe Ile 
    1355                 1360                 1365             


Ile Phe  Lys Ser Pro Thr Gly  Leu Phe Asn Arg Lys  Leu Tyr Leu 
    1370                 1375                 1380             


Lys Asn  Leu Lys Arg Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala 
    1385                 1390                 1395             


Lys Lys  Lys Lys Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1400                 1405                 1410             


Ala Thr  Pro Glu Ser Ser Gly  Ser Glu Val Glu Phe  Ser His Glu 
    1415                 1420                 1425             


Tyr Trp  Met Arg His Ala Leu  Thr Leu Ala Lys Arg  Ala Arg Asp 
    1430                 1435                 1440             


Glu Arg  Glu Val Pro Val Gly  Ala Val Leu Val Leu  Asn Asn Arg 
    1445                 1450                 1455             


Val Ile  Gly Glu Gly Trp Asn  Arg Ala Ile Gly Leu  His Asp Pro 
    1460                 1465                 1470             


Thr Ala  His Ala Glu Ile Met  Ala Leu Arg Gln Gly  Gly Leu Val 
    1475                 1480                 1485             


Met Gln  Asn Tyr Arg Leu Tyr  Asp Ala Thr Leu Tyr  Val Thr Phe 
    1490                 1495                 1500             


Glu Pro  Cys Val Met Cys Ala  Gly Ala Met Ile His  Ser Arg Ile 
    1505                 1510                 1515             


Gly Arg  Val Val Phe Gly Val  Arg Asn Ala Lys Thr  Gly Ala Ala 
    1520                 1525                 1530             


Gly Ser  Leu Met Asp Val Leu  His His Pro Gly Met  Asn His Arg 
    1535                 1540                 1545             


Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp Glu Cys  Ala Ala Leu 
    1550                 1555                 1560             


Leu Cys  Arg Phe Phe Arg Met  Pro Arg Arg Val Phe  Asn Ala Gln 
    1565                 1570                 1575             


Lys Lys  Ala Gln Ser Ser Thr  Asp Pro Ala Ala Lys  Arg Val Lys 
    1580                 1585                 1590             


Leu Asp  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1595                 1600                 1605             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1610                 1615                 1620             


Ala 
    


<210> 90
<211> 1888
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Ser Glu Lys Gly Pro 
1               5                   10                  15      


Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Ser Trp Glu Phe 
            20                  25                  30          


Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu 
        35                  40                  45              


Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly 
    50                  55                  60                  


Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr 
65                  70                  75                  80  


Ser Glu Arg Arg Phe His Ser Ser Ile Ser Cys Ser Ile Thr Trp Phe 
                85                  90                  95      


Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe 
            100                 105                 110         


Leu Ser Gln His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu 
        115                 120                 125             


Phe Trp His Met Asp Gln Arg Asn Arg Gln Gly Leu Arg Asp Leu Val 
    130                 135                 140                 


Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His 
145                 150                 155                 160 


Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp 
                165                 170                 175     


Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His 
            180                 185                 190         


Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp 
        195                 200                 205             


Gln Asn His Leu Ala Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr 
    210                 215                 220                 


Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro 
225                 230                 235                 240 


Ser Val Thr Trp Arg Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Lys 
        275                 280                 285             


Glu Tyr His Ile Gly Leu Ala Ile Gly Thr Ser Ser Ile Gly Trp Ala 
    290                 295                 300                 


Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile Lys Gly Lys Thr Ala 
305                 310                 315                 320 


Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala Ala Glu Arg Arg 
                325                 330                 335     


Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu 
            340                 345                 350         


His Tyr Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val Asp Glu 
        355                 360                 365             


Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu Asp Pro 
    370                 375                 380                 


Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp Leu Leu 
385                 390                 395                 400 


Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg Asp Glu 
                405                 410                 415     


Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile Tyr Lys 
            420                 425                 430         


Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu Arg Glu 
        435                 440                 445             


Val Tyr Leu Ala Val His His Ile Val Lys Tyr Arg Gly His Phe Leu 
    450                 455                 460                 


Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp Phe Asp 
465                 470                 475                 480 


Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln Asn Gly 
                485                 490                 495     


Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile Gly Gln 
            500                 505                 510         


Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp Arg Gln Lys Ala Val 
        515                 520                 525             


Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr Lys Arg 
    530                 535                 540                 


Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly Tyr Lys 
545                 550                 555                 560 


Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp Lys Ile 
                565                 570                 575     


Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe Arg Glu 
            580                 585                 590         


Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr Ser Leu 
        595                 600                 605             


Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met Ser Ile 
    610                 615                 620                 


Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln Leu Ala 
625                 630                 635                 640 


Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg Lys Glu 
                645                 650                 655     


Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys Glu Lys 
            660                 665                 670         


Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys Lys Glu 
        675                 680                 685             


Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe Leu Pro 
    690                 695                 700                 


Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met His Gln 
705                 710                 715                 720 


Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr Pro Trp 
                725                 730                 735     


Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His Gln Ala 
            740                 745                 750         


Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr Tyr Val 
        755                 760                 765             


Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly Ala Lys 
    770                 775                 780                 


Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro Trp Asn 
785                 790                 795                 800 


Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe Ile Lys 
                805                 810                 815     


Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val Leu Pro 
            820                 825                 830         


Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu Leu Asn 
        835                 840                 845             


Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys Gln Asp 
    850                 855                 860                 


Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Ala Gly Asp 
865                 870                 875                 880 


Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys Pro Ser 
                885                 890                 895     


Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu Ala Thr 
            900                 905                 910         


Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp Asn Arg 
        915                 920                 925             


Tyr Gln Met Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val Phe Glu 
    930                 935                 940                 


Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp Leu Thr 
945                 950                 955                 960 


Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly Trp Gly 
                965                 970                 975     


Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn Gly Gln 
            980                 985                 990         


Arg Ile Ile Asp Leu Met Trp Asn  Thr Asp Gln Asn Phe  Met Gln Ile 
        995                 1000                 1005             


Val Asn  Gln Pro Val Phe Lys  Glu Gln Ile Asp Gln  Leu Asn Gln 
    1010                 1015                 1020             


Lys Ala  Ile Thr Asn Asp Gly  Met Thr Leu Arg Glu  Arg Val Glu 
    1025                 1030                 1035             


Ser Val  Leu Asp Asp Ala Tyr  Thr Ser Pro Gln Asn  Lys Lys Ala 
    1040                 1045                 1050             


Ile Trp  Gln Val Val Arg Val  Val Glu Asp Ile Val  Lys Ala Val 
    1055                 1060                 1065             


Gly Asn  Ala Pro Lys Ser Ile  Ser Ile Glu Phe Ala  Arg Asn Glu 
    1070                 1075                 1080             


Gly Asn  Lys Gly Glu Ile Thr  Arg Ser Arg Arg Thr  Gln Leu Gln 
    1085                 1090                 1095             


Lys Leu  Phe Glu Asp Gln Ala  His Glu Leu Val Lys  Asp Thr Ser 
    1100                 1105                 1110             


Leu Thr  Glu Glu Leu Glu Lys  Ala Pro Asp Leu Ser  Asp Arg Tyr 
    1115                 1120                 1125             


Tyr Phe  Tyr Phe Thr Gln Gly  Gly Lys Asp Met Tyr  Thr Gly Asp 
    1130                 1135                 1140             


Pro Ile  Asn Phe Asp Glu Ile  Ser Thr Lys Tyr Asp  Ile Asp His 
    1145                 1150                 1155             


Ile Leu  Pro Gln Ser Phe Val  Lys Asp Asp Ser Leu  Asp Asn Arg 
    1160                 1165                 1170             


Val Leu  Val Ser Arg Ala Glu  Asn Asn Lys Lys Ser  Asp Arg Val 
    1175                 1180                 1185             


Pro Ala  Lys Leu Tyr Ala Ala  Lys Met Lys Pro Tyr  Trp Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Gly Leu Ile  Thr Gln Arg Lys Phe  Glu Asn Leu 
    1205                 1210                 1215             


Thr Met  Asp Val Asp Gln Thr  Ile Lys Tyr Arg Ser  Leu Gly Phe 
    1220                 1225                 1230             


Val Lys  Arg Gln Leu Val Glu  Thr Arg Gln Val Ile  Lys Leu Thr 
    1235                 1240                 1245             


Ala Asn  Ile Leu Gly Ser Met  Tyr Gln Glu Ala Gly  Thr Asp Ile 
    1250                 1255                 1260             


Ile Glu  Thr Arg Ala Gly Leu  Thr Lys Gln Leu Arg  Glu Glu Phe 
    1265                 1270                 1275             


Asp Leu  Pro Lys Val Arg Glu  Val Asn Asp Tyr His  His Ala Val 
    1280                 1285                 1290             


Asp Ala  Tyr Leu Thr Thr Phe  Ala Gly Gln Tyr Leu  Asn Arg Arg 
    1295                 1300                 1305             


Tyr Pro  Lys Leu Arg Ser Phe  Phe Val Tyr Gly Glu  Tyr Met Lys 
    1310                 1315                 1320             


Phe Lys  His Gly Ser Asp Leu  Lys Leu Arg Asn Phe  Asn Phe Phe 
    1325                 1330                 1335             


His Glu  Leu Met Glu Gly Asp  Lys Ser Gln Gly Lys  Val Val Asp 
    1340                 1345                 1350             


Gln Gln  Thr Gly Glu Leu Ile  Thr Thr Arg Asp Glu  Val Ala Asp 
    1355                 1360                 1365             


Tyr Phe  Asp Trp Val Ile Asn  Leu Lys Val Met Leu  Ile Ser Asn 
    1370                 1375                 1380             


Glu Thr  Tyr Glu Glu Thr Gly  Lys Tyr Phe Asp Ala  Ser His Glu 
    1385                 1390                 1395             


Ser Ser  Ser Leu Tyr Leu Lys  Asn Gln Asn Lys Lys  Ser Lys Leu 
    1400                 1405                 1410             


Val Val  Pro Leu Lys Asn Lys  Leu Gln Pro Glu Tyr  Tyr Gly Ala 
    1415                 1420                 1425             


Tyr Thr  Gly Ile Thr Gln Gly  Tyr Met Val Ile Leu  Lys Leu Leu 
    1430                 1435                 1440             


Asp Lys  Lys Gly Gly Phe Gly  Val Tyr Arg Ile Pro  Arg Tyr Ala 
    1445                 1450                 1455             


Ala Asp  Ile Leu Asn Lys Cys  His Asp Glu Val Ala  Tyr Arg Asn 
    1460                 1465                 1470             


Lys Ile  Ala Glu Ile Ile Ser  Ser Asp Pro Arg Ala  Pro Lys Ser 
    1475                 1480                 1485             


Phe Glu  Val Val Val Pro Arg  Val Leu Lys Gly Thr  Phe Leu Val 
    1490                 1495                 1500             


Asp Gly  Glu Glu Lys Phe Ile  Leu Ser Ser Tyr Arg  Tyr Lys Val 
    1505                 1510                 1515             


Asn Ala  Thr Gln Leu Ile Leu  Pro Val Ser Asp Ile  Lys Leu Ile 
    1520                 1525                 1530             


Gln Asp  Asn Phe Lys Ala Leu  Lys Lys Leu Asn Val  Glu Met Gln 
    1535                 1540                 1545             


Thr Lys  Lys Leu Ile Glu Ile  Tyr Asp Asn Ile Leu  Arg Gln Val 
    1550                 1555                 1560             


Asp Lys  Tyr Tyr Lys Leu Tyr  Asp Ile Asn Lys Phe  Arg Ala Lys 
    1565                 1570                 1575             


Leu His  Asp Gly Arg Ser Lys  Phe Val Glu Leu Asp  Asp Phe Gly 
    1580                 1585                 1590             


Gln Asp  Ala Ser Lys Glu Lys  Val Ile Ile Lys Ile  Leu Arg Gly 
    1595                 1600                 1605             


Leu His  Phe Gly Ser Asp Leu  Gln Asn Leu Lys Glu  Ile Gly Phe 
    1610                 1615                 1620             


Gly Thr  Thr Pro Leu Gly Gln  Phe Gln Val Ser Glu  Ala Gly Ile 
    1625                 1630                 1635             


Arg Leu  Ser Asn Thr Ala Phe  Ile Ile Phe Lys Ser  Pro Thr Gly 
    1640                 1645                 1650             


Leu Phe  Asn Arg Lys Leu Tyr  Leu Lys Asn Leu Gly  Lys Arg Pro 
    1655                 1660                 1665             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Gly Ser 
    1670                 1675                 1680             


Ser Gly  Gly Ser Gly Gly Ser  Gly Gly Ser Thr Asn  Leu Ser Asp 
    1685                 1690                 1695             


Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser 
    1700                 1705                 1710             


Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys 
    1715                 1720                 1725             


Pro Glu  Ser Asp Ile Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr 
    1730                 1735                 1740             


Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys 
    1745                 1750                 1755             


Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile 
    1760                 1765                 1770             


Lys Met  Leu Ser Gly Gly Ser  Gly Gly Ser Gly Gly  Ser Thr Asn 
    1775                 1780                 1785             


Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile 
    1790                 1795                 1800             


Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu Val Glu  Glu Val Ile 
    1805                 1810                 1815             


Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp 
    1820                 1825                 1830             


Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro 
    1835                 1840                 1845             


Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu 
    1850                 1855                 1860             


Asn Lys  Ile Lys Met Leu Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1865                 1870                 1875             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Tyr 
    1880                 1885             


<210> 91
<211> 1609
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Cys Arg Phe Phe Arg 
145                 150                 155                 160 


Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
            180                 185                 190         


Pro Glu Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Gly Glu Lys Lys 
        195                 200                 205             


Thr Asn Tyr Thr Ile Gly Leu Ala Ile Gly Thr Asp Ser Val Gly Trp 
    210                 215                 220                 


Ala Val Val Lys Asp Asp Leu Glu Leu Val Lys Lys Arg Met Lys Val 
225                 230                 235                 240 


Leu Gly Asn Thr Glu Thr Asn Tyr Ile Lys Lys Asn Leu Trp Gly Ser 
                245                 250                 255     


Leu Leu Phe Glu Ser Gly Gln Thr Ala Lys Asp Arg Arg Leu Lys Arg 
            260                 265                 270         


Val Ala Arg Arg Arg Tyr Glu Arg Arg Arg Asn Arg Leu Thr Glu Leu 
        275                 280                 285             


Gln Lys Ile Phe Ala Pro Ala Ile Asp Glu Val Asp Glu Asn Phe Phe 
    290                 295                 300                 


Phe Arg Leu Asn Glu Ser Phe Leu Val Pro Glu Asp Lys Ala Phe Ser 
305                 310                 315                 320 


Lys Asn Pro Ile Phe Gly Thr Leu Gly Glu Asp Lys Thr Tyr Tyr Lys 
                325                 330                 335     


Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln His Leu Ala Asp Ser Glu 
            340                 345                 350         


Glu Lys Ala Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
        355                 360                 365             


Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asp Thr Glu His 
    370                 375                 380                 


Ile Ala Ile Asn Glu Asn Leu Glu Gln Phe Phe Glu Ser Tyr Asn Ala 
385                 390                 395                 400 


Leu Phe Ser Glu Glu Pro Ile Glu Leu Arg Lys Glu Glu Leu Ile Ala 
                405                 410                 415     


Ile Glu Asn Ile Leu Arg Glu Lys Asn Ser Arg Thr Val Lys Glu Lys 
            420                 425                 430         


Arg Ile Thr Ser Phe Leu Lys Asp Ile Gly Arg Ala Asn Lys Gln Ser 
        435                 440                 445             


Pro Met Met Ala Phe Ile Thr Leu Ile Val Gly Lys Lys Ala Lys Phe 
    450                 455                 460                 


Lys Ala Ala Phe Asn Leu Glu Glu Glu Ile Ser Leu Asn Leu Thr Asp 
465                 470                 475                 480 


Asp Ser Tyr Asp Glu Asn Leu Glu Ile Leu Leu Asn Thr Ile Gly Ser 
                485                 490                 495     


Asp Phe Ala Asp Leu Phe Asp His Ala Gln Arg Val Tyr Asn Ala Val 
            500                 505                 510         


Glu Leu Ala Gly Ile Leu Ser Gly Asp Val Lys Asn Thr His Ala Lys 
        515                 520                 525             


Leu Ser Ala Gln Met Val Ala Met Tyr Glu Arg His Lys Glu Gln Leu 
    530                 535                 540                 


Lys Glu Tyr Lys Ser Phe Ile Lys Ala Asn Leu Pro Asp Gln Tyr Asp 
545                 550                 555                 560 


Met Thr Phe Val Ala Pro Lys Asp Ala Gln Lys Lys Asp Leu Lys Gly 
                565                 570                 575     


Tyr Ala Gly Tyr Ile Asp Gly Asn Met Ser Gln Asp Ser Phe Tyr Lys 
            580                 585                 590         


Phe Val Lys Asp Gln Leu Lys Glu Val Pro Gly Ser Glu Lys Phe Leu 
        595                 600                 605             


Asp Ser Ile Glu Lys Glu Asp Phe Leu Arg Lys Gln Arg Ser Phe Tyr 
    610                 615                 620                 


Asn Gly Val Ile Pro Asn Gln Val His Leu Ala Glu Met Glu Ala Ile 
625                 630                 635                 640 


Leu Asp Arg Gln Glu Asn Tyr Tyr Pro Trp Leu Lys Glu Asn Arg Glu 
                645                 650                 655     


Lys Ile Ile Ser Leu Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
            660                 665                 670         


Leu Ala Asp Gly Gln Ser Glu Phe Ala Trp Leu Glu Arg Lys Ser Asp 
        675                 680                 685             


Glu Lys Ile Lys Pro Trp Asn Phe Ser Asp Val Val Asp Leu Asp Arg 
    690                 695                 700                 


Ser Ala Glu Lys Phe Ile Glu Gln Leu Ile Gly Arg Asp Thr Tyr Leu 
705                 710                 715                 720 


Pro Asp Glu Tyr Val Leu Pro Lys Lys Ser Leu Ile Tyr Gln Lys Tyr 
                725                 730                 735     


Met Val Phe Asn Glu Leu Thr Lys Ile Ala Tyr Leu Asp Glu Arg Gln 
            740                 745                 750         


Lys Arg Met Asn Leu Ser Ser Val Glu Lys Lys Glu Ile Phe Glu Thr 
        755                 760                 765             


Leu Phe Lys Lys Arg Ser Lys Val Thr Glu Lys Gln Leu Val Lys Phe 
    770                 775                 780                 


Phe Glu Asn Tyr Leu Gln Ile Asp Asn Pro Thr Ile Phe Gly Ile Glu 
785                 790                 795                 800 


Asp Ala Phe Asn Ala Asp Tyr Ser Thr Tyr Val Glu Leu Ala Lys Val 
                805                 810                 815     


Pro Gly Met Lys Ser Met Met Asp Asp Pro Asp Asn Glu Asp Leu Met 
            820                 825                 830         


Glu Glu Ile Val Lys Ile Leu Thr Val Phe Glu Asp Arg Lys Met Arg 
        835                 840                 845             


Arg Lys Gln Leu Glu Lys Tyr Lys Glu Arg Leu Ser Pro Glu Gln Ile 
    850                 855                 860                 


Lys Glu Leu Ala Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
865                 870                 875                 880 


Lys Leu Leu Val Gly Ile Arg Asp Lys Glu Thr Gln Lys Thr Ile Leu 
                885                 890                 895     


Asp Tyr Leu Val Glu Asp Asp Asn His Ser Gly Gly Arg Gln His Leu 
            900                 905                 910         


Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Asp Arg Leu Ser Phe Lys 
        915                 920                 925             


Lys Thr Ile Ala Glu Leu Gln Met Ile Asp Pro Ser Ala Asp Leu Tyr 
    930                 935                 940                 


Ala Gln Val Gln Glu Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
945                 950                 955                 960 


Leu Leu Gly Leu Lys Ile Val Asp Glu Ile Ile Arg Val Met Gly Glu 
                965                 970                 975     


Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
            980                 985                 990         


Ala Arg Gly Lys Ala Leu Ser Lys  Arg Arg Glu Ala Lys  Ile Lys Glu 
        995                 1000                 1005             


Gly Leu  Ala Ala Leu Gly Ser  Ser Leu Leu Lys Glu  Asn Leu Pro 
    1010                 1015                 1020             


Gly Asn  Ala Asp Leu Ser Gln  Arg Lys Ile Tyr Leu  Tyr Tyr Thr 
    1025                 1030                 1035             


Gln Asn  Gly Lys Asp Ile Tyr  Leu Asp Glu Pro Leu  Asp Phe Asp 
    1040                 1045                 1050             


Arg Leu  Ser Gln Tyr Asp Glu  Asp His Ile Ile Pro  Gln Ser Phe 
    1055                 1060                 1065             


Thr Val  Asp Asn Ser Leu Asp  Asn Leu Val Leu Thr  Asn Ser Ser 
    1070                 1075                 1080             


Gln Asn  Arg Gly Asn Lys Lys  Asp Asp Val Pro Ser  Leu Glu Val 
    1085                 1090                 1095             


Val Asn  Arg Gln Leu Ala Tyr  Trp Arg Ser Leu Lys  Asp Ala Gly 
    1100                 1105                 1110             


Leu Met  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Met Arg 
    1115                 1120                 1125             


Gly Gly  Leu Thr Asp Lys Asp  Arg Glu Arg Phe Ile  Gln Arg Gln 
    1130                 1135                 1140             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys Asn Val Ala  Lys Leu Leu 
    1145                 1150                 1155             


Asp Met  Arg Leu Asn Asp Lys  Lys Asp Glu Ala Gly  Asn Lys Ile 
    1160                 1165                 1170             


Arg Glu  Thr Asn Ile Val Leu  Leu Lys Ser Ala Met  Ala Ser Glu 
    1175                 1180                 1185             


Phe Arg  Lys Met Phe Arg Leu  Tyr Lys Val Arg Glu  Leu Asn Asp 
    1190                 1195                 1200             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Ala  Ile Ala Ile 
    1205                 1210                 1215             


Asn Leu  Leu Ala Leu Tyr Pro  Tyr Met Ala Asp Asp  Phe Val Tyr 
    1220                 1225                 1230             


Gly Glu  Phe Arg Tyr Lys Lys  Lys Pro Gln Ala Glu  Lys Ala Thr 
    1235                 1240                 1245             


Tyr Glu  Lys Leu Arg Gln Trp  Asn Leu Ile Lys Arg  Phe Gly Glu 
    1250                 1255                 1260             


Lys Gln  Leu Phe Thr Pro Asp  His Glu Asp Cys Trp  Asn Lys Glu 
    1265                 1270                 1275             


Arg Asp  Ile Lys Thr Ile Lys  Lys Val Met Gly Tyr  Arg Gln Val 
    1280                 1285                 1290             


Asn Val  Val Lys Lys Ala Glu  Glu Arg Thr Gly Met  Leu Phe Lys 
    1295                 1300                 1305             


Glu Thr  Ile Asn Gly Lys Thr  Asn Lys Gly Ser Arg  Ile Pro Ile 
    1310                 1315                 1320             


Lys Lys  Asp Leu Asp Pro Ser  Lys Tyr Gly Gly Tyr  Ile Glu Glu 
    1325                 1330                 1335             


Lys Met  Ala Tyr Tyr Ala Val  Ile Ser Tyr Glu Asp  Lys Lys Lys 
    1340                 1345                 1350             


Lys Pro  Gly Lys Thr Ile Val  Gly Ile Ser Ile Met  Asp Lys Lys 
    1355                 1360                 1365             


Glu Phe  Glu Tyr Asp Ser Ile  Ser Tyr Leu Gly Lys  Leu Gly Phe 
    1370                 1375                 1380             


Ser Asn  Pro Val Val Gln Ile  Ile Leu Lys Asn Tyr  Ser Leu Ile 
    1385                 1390                 1395             


Ala Tyr  Pro Asp Gly Arg Arg  Arg Tyr Ile Thr Gly  Ala Thr Lys 
    1400                 1405                 1410             


Thr Thr  Lys Gly Lys Val Glu  Leu Gln Lys Ala Asn  Gln Ile Ala 
    1415                 1420                 1425             


Met Glu  Gln Asp Leu Val Asn  Phe Ile Tyr His Leu  Lys Asn Tyr 
    1430                 1435                 1440             


Asp Glu  Ile Ser His Pro Glu  Ser Tyr Ala Phe Val  Gln Ser His 
    1445                 1450                 1455             


Thr Asp  Tyr Phe Asp Arg Leu  Phe Asp Ser Ile Glu  His Tyr Thr 
    1460                 1465                 1470             


Arg Arg  Phe Leu Asp Ala Glu  Thr Asn Ile Asn Arg  Leu Arg Arg 
    1475                 1480                 1485             


Ile Tyr  Glu Glu Glu Lys Lys  Lys Asp Pro Val Asp  Ile Glu Ala 
    1490                 1495                 1500             


Leu Val  Ala Ser Phe Ile Glu  Leu Leu Lys Leu Thr  Ser Ala Gly 
    1505                 1510                 1515             


Ala Pro  Ala Asp Phe Ile Phe  Met Gly Glu Ala Ile  Ser Arg Arg 
    1520                 1525                 1530             


Arg Tyr  Asn Ser Met Thr Gly  Leu Phe Asp Gly Gln  Val Ile Tyr 
    1535                 1540                 1545             


Gln Ser  Leu Thr Gly Leu Tyr  Glu Thr Arg Met Arg  Phe Glu Asp 
    1550                 1555                 1560             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1565                 1570                 1575             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1580                 1585                 1590             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1595                 1600                 1605             


Ala 
    


<210> 92
<211> 1604
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Pro Lys Lys Lys Arg Lys Val Glu Lys Lys Thr Asn Tyr Thr Ile 
1               5                   10                  15      


Gly Leu Ala Ile Gly Thr Asp Ser Val Gly Trp Ala Val Val Lys Asp 
            20                  25                  30          


Asp Leu Glu Leu Val Lys Lys Arg Met Lys Val Leu Gly Asn Thr Glu 
        35                  40                  45              


Thr Asn Tyr Ile Lys Lys Asn Leu Trp Gly Ser Leu Leu Phe Glu Ser 
    50                  55                  60                  


Gly Gln Thr Ala Lys Asp Arg Arg Leu Lys Arg Val Ala Arg Arg Arg 
65                  70                  75                  80  


Tyr Glu Arg Arg Arg Asn Arg Leu Thr Glu Leu Gln Lys Ile Phe Ala 
                85                  90                  95      


Pro Ala Ile Asp Glu Val Asp Glu Asn Phe Phe Phe Arg Leu Asn Glu 
            100                 105                 110         


Ser Phe Leu Val Pro Glu Asp Lys Ala Phe Ser Lys Asn Pro Ile Phe 
        115                 120                 125             


Gly Thr Leu Gly Glu Asp Lys Thr Tyr Tyr Lys Thr Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Gln His Leu Ala Asp Ser Glu Glu Lys Ala Asp Val 
145                 150                 155                 160 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Ile Glu Gly Lys Leu Asp Thr Glu His Ile Ala Ile Asn Glu 
            180                 185                 190         


Asn Leu Glu Gln Phe Phe Glu Ser Tyr Asn Ala Leu Phe Ser Glu Glu 
        195                 200                 205             


Pro Ile Glu Leu Arg Lys Glu Glu Leu Ile Ala Ile Glu Asn Ile Leu 
    210                 215                 220                 


Arg Glu Lys Asn Ser Arg Thr Val Lys Glu Lys Arg Ile Thr Ser Phe 
225                 230                 235                 240 


Leu Lys Asp Ile Gly Arg Ala Asn Lys Gln Ser Pro Met Met Ala Phe 
                245                 250                 255     


Ile Thr Leu Ile Val Gly Lys Lys Ala Lys Phe Lys Ala Ala Phe Asn 
            260                 265                 270         


Leu Glu Glu Glu Ile Ser Leu Asn Leu Thr Asp Asp Ser Tyr Asp Glu 
        275                 280                 285             


Asn Leu Glu Ile Leu Leu Asn Thr Ile Gly Ser Asp Phe Ala Asp Leu 
    290                 295                 300                 


Phe Asp His Ala Gln Arg Val Tyr Asn Ala Val Glu Leu Ala Gly Ile 
305                 310                 315                 320 


Leu Ser Gly Asp Val Lys Asn Thr His Ala Lys Leu Ser Ala Gln Met 
                325                 330                 335     


Val Ala Met Tyr Glu Arg His Lys Glu Gln Leu Lys Glu Tyr Lys Ser 
            340                 345                 350         


Phe Ile Lys Ala Asn Leu Pro Asp Gln Tyr Asp Met Thr Phe Val Ala 
        355                 360                 365             


Pro Lys Asp Ala Gln Lys Lys Asp Leu Lys Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Asn Met Ser Gln Asp Ser Phe Tyr Lys Phe Val Lys Asp Gln 
385                 390                 395                 400 


Leu Lys Glu Val Pro Gly Ser Glu Lys Phe Leu Asp Ser Ile Glu Lys 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Ser Phe Tyr Asn Gly Val Ile Pro 
            420                 425                 430         


Asn Gln Val His Leu Ala Glu Met Glu Ala Ile Leu Asp Arg Gln Glu 
        435                 440                 445             


Asn Tyr Tyr Pro Trp Leu Lys Glu Asn Arg Glu Lys Ile Ile Ser Leu 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Asp Gly Gln 
465                 470                 475                 480 


Ser Glu Phe Ala Trp Leu Glu Arg Lys Ser Asp Glu Lys Ile Lys Pro 
                485                 490                 495     


Trp Asn Phe Ser Asp Val Val Asp Leu Asp Arg Ser Ala Glu Lys Phe 
            500                 505                 510         


Ile Glu Gln Leu Ile Gly Arg Asp Thr Tyr Leu Pro Asp Glu Tyr Val 
        515                 520                 525             


Leu Pro Lys Lys Ser Leu Ile Tyr Gln Lys Tyr Met Val Phe Asn Glu 
    530                 535                 540                 


Leu Thr Lys Ile Ala Tyr Leu Asp Glu Arg Gln Lys Arg Met Asn Leu 
545                 550                 555                 560 


Ser Ser Val Glu Lys Lys Glu Ile Phe Glu Thr Leu Phe Lys Lys Arg 
                565                 570                 575     


Ser Lys Val Thr Glu Lys Gln Leu Val Lys Phe Phe Glu Asn Tyr Leu 
            580                 585                 590         


Gln Ile Asp Asn Pro Thr Ile Phe Gly Ile Glu Asp Ala Phe Asn Ala 
        595                 600                 605             


Asp Tyr Ser Thr Tyr Val Glu Leu Ala Lys Val Pro Gly Met Lys Ser 
    610                 615                 620                 


Met Met Asp Asp Pro Asp Asn Glu Asp Leu Met Glu Glu Ile Val Lys 
625                 630                 635                 640 


Ile Leu Thr Val Phe Glu Asp Arg Lys Met Arg Arg Lys Gln Leu Glu 
                645                 650                 655     


Lys Tyr Lys Glu Arg Leu Ser Pro Glu Gln Ile Lys Glu Leu Ala Lys 
            660                 665                 670         


Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Val Gly 
        675                 680                 685             


Ile Arg Asp Lys Glu Thr Gln Lys Thr Ile Leu Asp Tyr Leu Val Glu 
    690                 695                 700                 


Asp Asp Asn His Ser Gly Gly Arg Gln His Leu Asn Arg Asn Leu Met 
705                 710                 715                 720 


Gln Leu Ile Asn Asp Asp Arg Leu Ser Phe Lys Lys Thr Ile Ala Glu 
                725                 730                 735     


Leu Gln Met Ile Asp Pro Ser Ala Asp Leu Tyr Ala Gln Val Gln Glu 
            740                 745                 750         


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Leu Gly Leu Lys 
        755                 760                 765             


Ile Val Asp Glu Ile Ile Arg Val Met Gly Glu Lys Pro Glu Asn Ile 
    770                 775                 780                 


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Arg Gly Lys Ala 
785                 790                 795                 800 


Leu Ser Lys Arg Arg Glu Ala Lys Ile Lys Glu Gly Leu Ala Ala Leu 
                805                 810                 815     


Gly Ser Ser Leu Leu Lys Glu Asn Leu Pro Gly Asn Ala Asp Leu Ser 
            820                 825                 830         


Gln Arg Lys Ile Tyr Leu Tyr Tyr Thr Gln Asn Gly Lys Asp Ile Tyr 
        835                 840                 845             


Leu Asp Glu Pro Leu Asp Phe Asp Arg Leu Ser Gln Tyr Asp Glu Asp 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Phe Thr Val Asp Asn Ser Leu Asp Asn Leu 
865                 870                 875                 880 


Val Leu Thr Asn Ser Ser Gln Asn Arg Gly Asn Lys Lys Asp Asp Val 
                885                 890                 895     


Pro Ser Leu Glu Val Val Asn Arg Gln Leu Ala Tyr Trp Arg Ser Leu 
            900                 905                 910         


Lys Asp Ala Gly Leu Met Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys 
        915                 920                 925             


Ala Met Arg Gly Gly Leu Thr Asp Lys Asp Arg Glu Arg Phe Ile Gln 
    930                 935                 940                 


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Lys Leu 
945                 950                 955                 960 


Leu Asp Met Arg Leu Asn Asp Lys Lys Asp Glu Ala Gly Asn Lys Ile 
                965                 970                 975     


Arg Glu Thr Asn Ile Val Leu Leu Lys Ser Ala Met Ala Ser Glu Phe 
            980                 985                 990         


Arg Lys Met Phe Arg Leu Tyr Lys  Val Arg Glu Leu Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  His Asp Ala Tyr Leu  Asn Ala Ala Ile Ala  Ile Asn Leu 
    1010                 1015                 1020             


Leu Ala  Leu Tyr Pro Tyr Met  Ala Asp Asp Phe Val  Tyr Gly Glu 
    1025                 1030                 1035             


Phe Arg  Tyr Lys Lys Lys Pro  Gln Ala Glu Lys Ala  Thr Tyr Glu 
    1040                 1045                 1050             


Lys Leu  Arg Gln Trp Asn Leu  Ile Lys Arg Phe Gly  Glu Lys Gln 
    1055                 1060                 1065             


Leu Phe  Thr Pro Asp His Glu  Asp Cys Trp Asn Lys  Glu Arg Asp 
    1070                 1075                 1080             


Ile Lys  Thr Ile Lys Lys Val  Met Gly Tyr Arg Gln  Val Asn Val 
    1085                 1090                 1095             


Val Lys  Lys Ala Glu Glu Arg  Thr Gly Met Leu Phe  Lys Glu Thr 
    1100                 1105                 1110             


Ile Asn  Gly Lys Thr Asn Lys  Gly Ser Arg Ile Pro  Ile Lys Lys 
    1115                 1120                 1125             


Asp Leu  Asp Pro Ser Lys Tyr  Gly Gly Tyr Ile Glu  Glu Lys Met 
    1130                 1135                 1140             


Ala Tyr  Tyr Ala Val Ile Ser  Tyr Glu Asp Lys Lys  Lys Lys Pro 
    1145                 1150                 1155             


Gly Lys  Thr Ile Val Gly Ile  Ser Ile Met Asp Lys  Lys Glu Phe 
    1160                 1165                 1170             


Glu Tyr  Asp Ser Ile Ser Tyr  Leu Gly Lys Leu Gly  Phe Ser Asn 
    1175                 1180                 1185             


Pro Val  Val Gln Ile Ile Leu  Lys Asn Tyr Ser Leu  Ile Ala Tyr 
    1190                 1195                 1200             


Pro Asp  Gly Arg Arg Arg Tyr  Ile Thr Gly Ala Thr  Lys Thr Thr 
    1205                 1210                 1215             


Lys Gly  Lys Val Glu Leu Gln  Lys Ala Asn Gln Ile  Ala Met Glu 
    1220                 1225                 1230             


Gln Asp  Leu Val Asn Phe Ile  Tyr His Leu Lys Asn  Tyr Asp Glu 
    1235                 1240                 1245             


Ile Ser  His Pro Glu Ser Tyr  Ala Phe Val Gln Ser  His Thr Asp 
    1250                 1255                 1260             


Tyr Phe  Asp Arg Leu Phe Asp  Ser Ile Glu His Tyr  Thr Arg Arg 
    1265                 1270                 1275             


Phe Leu  Asp Ala Glu Thr Asn  Ile Asn Arg Leu Arg  Arg Ile Tyr 
    1280                 1285                 1290             


Glu Glu  Glu Lys Lys Lys Asp  Pro Val Asp Ile Glu  Ala Leu Val 
    1295                 1300                 1305             


Ala Ser  Phe Ile Glu Leu Leu  Lys Leu Thr Ser Ala  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Ile Phe Met Gly  Glu Ala Ile Ser Arg  Arg Arg Tyr 
    1325                 1330                 1335             


Asn Ser  Met Thr Gly Leu Phe  Asp Gly Gln Val Ile  Tyr Gln Ser 
    1340                 1345                 1350             


Leu Thr  Gly Leu Tyr Glu Thr  Arg Met Arg Phe Glu  Asp Lys Arg 
    1355                 1360                 1365             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys Ser 
    1370                 1375                 1380             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1385                 1390                 1395             


Ser Gly  Ser Glu Val Glu Phe  Ser His Glu Tyr Trp  Met Arg His 
    1400                 1405                 1410             


Ala Leu  Thr Leu Ala Lys Arg  Ala Arg Asp Glu Arg  Glu Val Pro 
    1415                 1420                 1425             


Val Gly  Ala Val Leu Val Leu  Asn Asn Arg Val Ile  Gly Glu Gly 
    1430                 1435                 1440             


Trp Asn  Arg Ala Ile Gly Leu  His Asp Pro Thr Ala  His Ala Glu 
    1445                 1450                 1455             


Ile Met  Ala Leu Arg Gln Gly  Gly Leu Val Met Gln  Asn Tyr Arg 
    1460                 1465                 1470             


Leu Tyr  Asp Ala Thr Leu Tyr  Val Thr Phe Glu Pro  Cys Val Met 
    1475                 1480                 1485             


Cys Ala  Gly Ala Met Ile His  Ser Arg Ile Gly Arg  Val Val Phe 
    1490                 1495                 1500             


Gly Val  Arg Asn Ala Lys Thr  Gly Ala Ala Gly Ser  Leu Met Asp 
    1505                 1510                 1515             


Val Leu  His His Pro Gly Met  Asn His Arg Val Glu  Ile Thr Glu 
    1520                 1525                 1530             


Gly Ile  Leu Ala Asp Glu Cys  Ala Ala Leu Leu Cys  Arg Phe Phe 
    1535                 1540                 1545             


Arg Met  Pro Arg Arg Val Phe  Asn Ala Gln Lys Lys  Ala Gln Ser 
    1550                 1555                 1560             


Ser Thr  Asp Pro Ala Ala Lys  Arg Val Lys Leu Asp  Gly Ser Tyr 
    1565                 1570                 1575             


Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro Tyr Asp  Val Pro Asp 
    1580                 1585                 1590             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala 
    1595                 1600                 


<210> 93
<211> 1869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Ser Glu Lys Gly Pro 
1               5                   10                  15      


Ser Thr Gly Asp Pro Thr Leu Arg Arg Arg Ile Glu Ser Trp Glu Phe 
            20                  25                  30          


Asp Val Phe Tyr Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu 
        35                  40                  45              


Tyr Glu Ile Lys Trp Gly Met Ser Arg Lys Ile Trp Arg Ser Ser Gly 
    50                  55                  60                  


Lys Asn Thr Thr Asn His Val Glu Val Asn Phe Ile Lys Lys Phe Thr 
65                  70                  75                  80  


Ser Glu Arg Arg Phe His Ser Ser Ile Ser Cys Ser Ile Thr Trp Phe 
                85                  90                  95      


Leu Ser Trp Ser Pro Cys Trp Glu Cys Ser Gln Ala Ile Arg Glu Phe 
            100                 105                 110         


Leu Ser Gln His Pro Gly Val Thr Leu Val Ile Tyr Val Ala Arg Leu 
        115                 120                 125             


Phe Trp His Met Asp Gln Arg Asn Arg Gln Gly Leu Arg Asp Leu Val 
    130                 135                 140                 


Asn Ser Gly Val Thr Ile Gln Ile Met Arg Ala Ser Glu Tyr Tyr His 
145                 150                 155                 160 


Cys Trp Arg Asn Phe Val Asn Tyr Pro Pro Gly Asp Glu Ala His Trp 
                165                 170                 175     


Pro Gln Tyr Pro Pro Leu Trp Met Met Leu Tyr Ala Leu Glu Leu His 
            180                 185                 190         


Cys Ile Ile Leu Ser Leu Pro Pro Cys Leu Lys Ile Ser Arg Arg Trp 
        195                 200                 205             


Gln Asn His Leu Ala Phe Phe Arg Leu His Leu Gln Asn Cys His Tyr 
    210                 215                 220                 


Gln Thr Ile Pro Pro His Ile Leu Leu Ala Thr Gly Leu Ile His Pro 
225                 230                 235                 240 


Ser Val Thr Trp Arg Leu Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                245                 250                 255     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            260                 265                 270         


Gly Gly Ser Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Glu 
        275                 280                 285             


Lys Lys Thr Asn Tyr Thr Ile Gly Leu Ala Ile Gly Thr Asp Ser Val 
    290                 295                 300                 


Gly Trp Ala Val Val Lys Asp Asp Leu Glu Leu Val Lys Lys Arg Met 
305                 310                 315                 320 


Lys Val Leu Gly Asn Thr Glu Thr Asn Tyr Ile Lys Lys Asn Leu Trp 
                325                 330                 335     


Gly Ser Leu Leu Phe Glu Ser Gly Gln Thr Ala Lys Asp Arg Arg Leu 
            340                 345                 350         


Lys Arg Val Ala Arg Arg Arg Tyr Glu Arg Arg Arg Asn Arg Leu Thr 
        355                 360                 365             


Glu Leu Gln Lys Ile Phe Ala Pro Ala Ile Asp Glu Val Asp Glu Asn 
    370                 375                 380                 


Phe Phe Phe Arg Leu Asn Glu Ser Phe Leu Val Pro Glu Asp Lys Ala 
385                 390                 395                 400 


Phe Ser Lys Asn Pro Ile Phe Gly Thr Leu Gly Glu Asp Lys Thr Tyr 
                405                 410                 415     


Tyr Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln His Leu Ala Asp 
            420                 425                 430         


Ser Glu Glu Lys Ala Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His 
        435                 440                 445             


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asp Thr 
    450                 455                 460                 


Glu His Ile Ala Ile Asn Glu Asn Leu Glu Gln Phe Phe Glu Ser Tyr 
465                 470                 475                 480 


Asn Ala Leu Phe Ser Glu Glu Pro Ile Glu Leu Arg Lys Glu Glu Leu 
                485                 490                 495     


Ile Ala Ile Glu Asn Ile Leu Arg Glu Lys Asn Ser Arg Thr Val Lys 
            500                 505                 510         


Glu Lys Arg Ile Thr Ser Phe Leu Lys Asp Ile Gly Arg Ala Asn Lys 
        515                 520                 525             


Gln Ser Pro Met Met Ala Phe Ile Thr Leu Ile Val Gly Lys Lys Ala 
    530                 535                 540                 


Lys Phe Lys Ala Ala Phe Asn Leu Glu Glu Glu Ile Ser Leu Asn Leu 
545                 550                 555                 560 


Thr Asp Asp Ser Tyr Asp Glu Asn Leu Glu Ile Leu Leu Asn Thr Ile 
                565                 570                 575     


Gly Ser Asp Phe Ala Asp Leu Phe Asp His Ala Gln Arg Val Tyr Asn 
            580                 585                 590         


Ala Val Glu Leu Ala Gly Ile Leu Ser Gly Asp Val Lys Asn Thr His 
        595                 600                 605             


Ala Lys Leu Ser Ala Gln Met Val Ala Met Tyr Glu Arg His Lys Glu 
    610                 615                 620                 


Gln Leu Lys Glu Tyr Lys Ser Phe Ile Lys Ala Asn Leu Pro Asp Gln 
625                 630                 635                 640 


Tyr Asp Met Thr Phe Val Ala Pro Lys Asp Ala Gln Lys Lys Asp Leu 
                645                 650                 655     


Lys Gly Tyr Ala Gly Tyr Ile Asp Gly Asn Met Ser Gln Asp Ser Phe 
            660                 665                 670         


Tyr Lys Phe Val Lys Asp Gln Leu Lys Glu Val Pro Gly Ser Glu Lys 
        675                 680                 685             


Phe Leu Asp Ser Ile Glu Lys Glu Asp Phe Leu Arg Lys Gln Arg Ser 
    690                 695                 700                 


Phe Tyr Asn Gly Val Ile Pro Asn Gln Val His Leu Ala Glu Met Glu 
705                 710                 715                 720 


Ala Ile Leu Asp Arg Gln Glu Asn Tyr Tyr Pro Trp Leu Lys Glu Asn 
                725                 730                 735     


Arg Glu Lys Ile Ile Ser Leu Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
            740                 745                 750         


Gly Pro Leu Ala Asp Gly Gln Ser Glu Phe Ala Trp Leu Glu Arg Lys 
        755                 760                 765             


Ser Asp Glu Lys Ile Lys Pro Trp Asn Phe Ser Asp Val Val Asp Leu 
    770                 775                 780                 


Asp Arg Ser Ala Glu Lys Phe Ile Glu Gln Leu Ile Gly Arg Asp Thr 
785                 790                 795                 800 


Tyr Leu Pro Asp Glu Tyr Val Leu Pro Lys Lys Ser Leu Ile Tyr Gln 
                805                 810                 815     


Lys Tyr Met Val Phe Asn Glu Leu Thr Lys Ile Ala Tyr Leu Asp Glu 
            820                 825                 830         


Arg Gln Lys Arg Met Asn Leu Ser Ser Val Glu Lys Lys Glu Ile Phe 
        835                 840                 845             


Glu Thr Leu Phe Lys Lys Arg Ser Lys Val Thr Glu Lys Gln Leu Val 
    850                 855                 860                 


Lys Phe Phe Glu Asn Tyr Leu Gln Ile Asp Asn Pro Thr Ile Phe Gly 
865                 870                 875                 880 


Ile Glu Asp Ala Phe Asn Ala Asp Tyr Ser Thr Tyr Val Glu Leu Ala 
                885                 890                 895     


Lys Val Pro Gly Met Lys Ser Met Met Asp Asp Pro Asp Asn Glu Asp 
            900                 905                 910         


Leu Met Glu Glu Ile Val Lys Ile Leu Thr Val Phe Glu Asp Arg Lys 
        915                 920                 925             


Met Arg Arg Lys Gln Leu Glu Lys Tyr Lys Glu Arg Leu Ser Pro Glu 
    930                 935                 940                 


Gln Ile Lys Glu Leu Ala Lys Lys His Tyr Thr Gly Trp Gly Arg Leu 
945                 950                 955                 960 


Ser Lys Lys Leu Leu Val Gly Ile Arg Asp Lys Glu Thr Gln Lys Thr 
                965                 970                 975     


Ile Leu Asp Tyr Leu Val Glu Asp Asp Asn His Ser Gly Gly Arg Gln 
            980                 985                 990         


His Leu Asn Arg Asn Leu Met Gln  Leu Ile Asn Asp Asp  Arg Leu Ser 
        995                 1000                 1005             


Phe Lys  Lys Thr Ile Ala Glu  Leu Gln Met Ile Asp  Pro Ser Ala 
    1010                 1015                 1020             


Asp Leu  Tyr Ala Gln Val Gln  Glu Ile Ala Gly Ser  Pro Ala Ile 
    1025                 1030                 1035             


Lys Lys  Gly Ile Leu Leu Gly  Leu Lys Ile Val Asp  Glu Ile Ile 
    1040                 1045                 1050             


Arg Val  Met Gly Glu Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1055                 1060                 1065             


Arg Glu  Asn Gln Thr Thr Ala  Arg Gly Lys Ala Leu  Ser Lys Arg 
    1070                 1075                 1080             


Arg Glu  Ala Lys Ile Lys Glu  Gly Leu Ala Ala Leu  Gly Ser Ser 
    1085                 1090                 1095             


Leu Leu  Lys Glu Asn Leu Pro  Gly Asn Ala Asp Leu  Ser Gln Arg 
    1100                 1105                 1110             


Lys Ile  Tyr Leu Tyr Tyr Thr  Gln Asn Gly Lys Asp  Ile Tyr Leu 
    1115                 1120                 1125             


Asp Glu  Pro Leu Asp Phe Asp  Arg Leu Ser Gln Tyr  Asp Glu Asp 
    1130                 1135                 1140             


His Ile  Ile Pro Gln Ser Phe  Thr Val Asp Asn Ser  Leu Asp Asn 
    1145                 1150                 1155             


Leu Val  Leu Thr Asn Ser Ser  Gln Asn Arg Gly Asn  Lys Lys Asp 
    1160                 1165                 1170             


Asp Val  Pro Ser Leu Glu Val  Val Asn Arg Gln Leu  Ala Tyr Trp 
    1175                 1180                 1185             


Arg Ser  Leu Lys Asp Ala Gly  Leu Met Thr Gln Arg  Lys Phe Asp 
    1190                 1195                 1200             


Asn Leu  Thr Lys Ala Met Arg  Gly Gly Leu Thr Asp  Lys Asp Arg 
    1205                 1210                 1215             


Glu Arg  Phe Ile Gln Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1220                 1225                 1230             


Lys Asn  Val Ala Lys Leu Leu  Asp Met Arg Leu Asn  Asp Lys Lys 
    1235                 1240                 1245             


Asp Glu  Ala Gly Asn Lys Ile  Arg Glu Thr Asn Ile  Val Leu Leu 
    1250                 1255                 1260             


Lys Ser  Ala Met Ala Ser Glu  Phe Arg Lys Met Phe  Arg Leu Tyr 
    1265                 1270                 1275             


Lys Val  Arg Glu Leu Asn Asp  Tyr His His Ala His  Asp Ala Tyr 
    1280                 1285                 1290             


Leu Asn  Ala Ala Ile Ala Ile  Asn Leu Leu Ala Leu  Tyr Pro Tyr 
    1295                 1300                 1305             


Met Ala  Asp Asp Phe Val Tyr  Gly Glu Phe Arg Tyr  Lys Lys Lys 
    1310                 1315                 1320             


Pro Gln  Ala Glu Lys Ala Thr  Tyr Glu Lys Leu Arg  Gln Trp Asn 
    1325                 1330                 1335             


Leu Ile  Lys Arg Phe Gly Glu  Lys Gln Leu Phe Thr  Pro Asp His 
    1340                 1345                 1350             


Glu Asp  Cys Trp Asn Lys Glu  Arg Asp Ile Lys Thr  Ile Lys Lys 
    1355                 1360                 1365             


Val Met  Gly Tyr Arg Gln Val  Asn Val Val Lys Lys  Ala Glu Glu 
    1370                 1375                 1380             


Arg Thr  Gly Met Leu Phe Lys  Glu Thr Ile Asn Gly  Lys Thr Asn 
    1385                 1390                 1395             


Lys Gly  Ser Arg Ile Pro Ile  Lys Lys Asp Leu Asp  Pro Ser Lys 
    1400                 1405                 1410             


Tyr Gly  Gly Tyr Ile Glu Glu  Lys Met Ala Tyr Tyr  Ala Val Ile 
    1415                 1420                 1425             


Ser Tyr  Glu Asp Lys Lys Lys  Lys Pro Gly Lys Thr  Ile Val Gly 
    1430                 1435                 1440             


Ile Ser  Ile Met Asp Lys Lys  Glu Phe Glu Tyr Asp  Ser Ile Ser 
    1445                 1450                 1455             


Tyr Leu  Gly Lys Leu Gly Phe  Ser Asn Pro Val Val  Gln Ile Ile 
    1460                 1465                 1470             


Leu Lys  Asn Tyr Ser Leu Ile  Ala Tyr Pro Asp Gly  Arg Arg Arg 
    1475                 1480                 1485             


Tyr Ile  Thr Gly Ala Thr Lys  Thr Thr Lys Gly Lys  Val Glu Leu 
    1490                 1495                 1500             


Gln Lys  Ala Asn Gln Ile Ala  Met Glu Gln Asp Leu  Val Asn Phe 
    1505                 1510                 1515             


Ile Tyr  His Leu Lys Asn Tyr  Asp Glu Ile Ser His  Pro Glu Ser 
    1520                 1525                 1530             


Tyr Ala  Phe Val Gln Ser His  Thr Asp Tyr Phe Asp  Arg Leu Phe 
    1535                 1540                 1545             


Asp Ser  Ile Glu His Tyr Thr  Arg Arg Phe Leu Asp  Ala Glu Thr 
    1550                 1555                 1560             


Asn Ile  Asn Arg Leu Arg Arg  Ile Tyr Glu Glu Glu  Lys Lys Lys 
    1565                 1570                 1575             


Asp Pro  Val Asp Ile Glu Ala  Leu Val Ala Ser Phe  Ile Glu Leu 
    1580                 1585                 1590             


Leu Lys  Leu Thr Ser Ala Gly  Ala Pro Ala Asp Phe  Ile Phe Met 
    1595                 1600                 1605             


Gly Glu  Ala Ile Ser Arg Arg  Arg Tyr Asn Ser Met  Thr Gly Leu 
    1610                 1615                 1620             


Phe Asp  Gly Gln Val Ile Tyr  Gln Ser Leu Thr Gly  Leu Tyr Glu 
    1625                 1630                 1635             


Thr Arg  Met Arg Phe Glu Asp  Gly Lys Arg Pro Ala  Ala Thr Lys 
    1640                 1645                 1650             


Lys Ala  Gly Gln Ala Lys Lys  Lys Lys Gly Ser Ser  Gly Gly Ser 
    1655                 1660                 1665             


Gly Gly  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1670                 1675                 1680             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1685                 1690                 1695             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1700                 1705                 1710             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1715                 1720                 1725             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1730                 1735                 1740             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1745                 1750                 1755             


Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Thr Asn Leu  Ser Asp Ile 
    1760                 1765                 1770             


Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile 
    1775                 1780                 1785             


Leu Met  Leu Pro Glu Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro 
    1790                 1795                 1800             


Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp 
    1805                 1810                 1815             


Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro 
    1820                 1825                 1830             


Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys 
    1835                 1840                 1845             


Met Leu  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1850                 1855                 1860             


Val Pro  Asp Tyr Ala Tyr 
    1865                 


<210> 94
<211> 1873
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Pro Ala Ala Lys Arg Val Lys Leu Asp Thr Asn Leu Ser Asp Ile 
1               5                   10                  15      


Ile Glu Lys Glu Thr Gly Lys Gln Leu Val Ile Gln Glu Ser Ile Leu 
            20                  25                  30          


Met Leu Pro Glu Glu Val Glu Glu Val Ile Gly Asn Lys Pro Glu Ser 
        35                  40                  45              


Asp Ile Leu Val His Thr Ala Tyr Asp Glu Ser Thr Asp Glu Asn Val 
    50                  55                  60                  


Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr Lys Pro Trp Ala Leu Val 
65                  70                  75                  80  


Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile Lys Met Leu Ser Gly Gly 
                85                  90                  95      


Ser Gly Gly Ser Gly Gly Ser Thr Asn Leu Ser Asp Ile Ile Glu Lys 
            100                 105                 110         


Glu Thr Gly Lys Gln Leu Val Ile Gln Glu Ser Ile Leu Met Leu Pro 
        115                 120                 125             


Glu Glu Val Glu Glu Val Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu 
    130                 135                 140                 


Val His Thr Ala Tyr Asp Glu Ser Thr Asp Glu Asn Val Met Leu Leu 
145                 150                 155                 160 


Thr Ser Asp Ala Pro Glu Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp 
                165                 170                 175     


Ser Asn Gly Glu Asn Lys Ile Lys Met Leu Ser Gly Gly Ser Gly Gly 
            180                 185                 190         


Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Glu Lys Lys Thr Asn 
        195                 200                 205             


Tyr Thr Ile Gly Leu Ala Ile Gly Thr Asp Ser Val Gly Trp Ala Val 
    210                 215                 220                 


Val Lys Asp Asp Leu Glu Leu Val Lys Lys Arg Met Lys Val Leu Gly 
225                 230                 235                 240 


Asn Thr Glu Thr Asn Tyr Ile Lys Lys Asn Leu Trp Gly Ser Leu Leu 
                245                 250                 255     


Phe Glu Ser Gly Gln Thr Ala Lys Asp Arg Arg Leu Lys Arg Val Ala 
            260                 265                 270         


Arg Arg Arg Tyr Glu Arg Arg Arg Asn Arg Leu Thr Glu Leu Gln Lys 
        275                 280                 285             


Ile Phe Ala Pro Ala Ile Asp Glu Val Asp Glu Asn Phe Phe Phe Arg 
    290                 295                 300                 


Leu Asn Glu Ser Phe Leu Val Pro Glu Asp Lys Ala Phe Ser Lys Asn 
305                 310                 315                 320 


Pro Ile Phe Gly Thr Leu Gly Glu Asp Lys Thr Tyr Tyr Lys Thr Tyr 
                325                 330                 335     


Pro Thr Ile Tyr His Leu Arg Gln His Leu Ala Asp Ser Glu Glu Lys 
            340                 345                 350         


Ala Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Tyr 
        355                 360                 365             


Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asp Thr Glu His Ile Ala 
    370                 375                 380                 


Ile Asn Glu Asn Leu Glu Gln Phe Phe Glu Ser Tyr Asn Ala Leu Phe 
385                 390                 395                 400 


Ser Glu Glu Pro Ile Glu Leu Arg Lys Glu Glu Leu Ile Ala Ile Glu 
                405                 410                 415     


Asn Ile Leu Arg Glu Lys Asn Ser Arg Thr Val Lys Glu Lys Arg Ile 
            420                 425                 430         


Thr Ser Phe Leu Lys Asp Ile Gly Arg Ala Asn Lys Gln Ser Pro Met 
        435                 440                 445             


Met Ala Phe Ile Thr Leu Ile Val Gly Lys Lys Ala Lys Phe Lys Ala 
    450                 455                 460                 


Ala Phe Asn Leu Glu Glu Glu Ile Ser Leu Asn Leu Thr Asp Asp Ser 
465                 470                 475                 480 


Tyr Asp Glu Asn Leu Glu Ile Leu Leu Asn Thr Ile Gly Ser Asp Phe 
                485                 490                 495     


Ala Asp Leu Phe Asp His Ala Gln Arg Val Tyr Asn Ala Val Glu Leu 
            500                 505                 510         


Ala Gly Ile Leu Ser Gly Asp Val Lys Asn Thr His Ala Lys Leu Ser 
        515                 520                 525             


Ala Gln Met Val Ala Met Tyr Glu Arg His Lys Glu Gln Leu Lys Glu 
    530                 535                 540                 


Tyr Lys Ser Phe Ile Lys Ala Asn Leu Pro Asp Gln Tyr Asp Met Thr 
545                 550                 555                 560 


Phe Val Ala Pro Lys Asp Ala Gln Lys Lys Asp Leu Lys Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Asn Met Ser Gln Asp Ser Phe Tyr Lys Phe Val 
            580                 585                 590         


Lys Asp Gln Leu Lys Glu Val Pro Gly Ser Glu Lys Phe Leu Asp Ser 
        595                 600                 605             


Ile Glu Lys Glu Asp Phe Leu Arg Lys Gln Arg Ser Phe Tyr Asn Gly 
    610                 615                 620                 


Val Ile Pro Asn Gln Val His Leu Ala Glu Met Glu Ala Ile Leu Asp 
625                 630                 635                 640 


Arg Gln Glu Asn Tyr Tyr Pro Trp Leu Lys Glu Asn Arg Glu Lys Ile 
                645                 650                 655     


Ile Ser Leu Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Asp Gly Gln Ser Glu Phe Ala Trp Leu Glu Arg Lys Ser Asp Glu Lys 
        675                 680                 685             


Ile Lys Pro Trp Asn Phe Ser Asp Val Val Asp Leu Asp Arg Ser Ala 
    690                 695                 700                 


Glu Lys Phe Ile Glu Gln Leu Ile Gly Arg Asp Thr Tyr Leu Pro Asp 
705                 710                 715                 720 


Glu Tyr Val Leu Pro Lys Lys Ser Leu Ile Tyr Gln Lys Tyr Met Val 
                725                 730                 735     


Phe Asn Glu Leu Thr Lys Ile Ala Tyr Leu Asp Glu Arg Gln Lys Arg 
            740                 745                 750         


Met Asn Leu Ser Ser Val Glu Lys Lys Glu Ile Phe Glu Thr Leu Phe 
        755                 760                 765             


Lys Lys Arg Ser Lys Val Thr Glu Lys Gln Leu Val Lys Phe Phe Glu 
    770                 775                 780                 


Asn Tyr Leu Gln Ile Asp Asn Pro Thr Ile Phe Gly Ile Glu Asp Ala 
785                 790                 795                 800 


Phe Asn Ala Asp Tyr Ser Thr Tyr Val Glu Leu Ala Lys Val Pro Gly 
                805                 810                 815     


Met Lys Ser Met Met Asp Asp Pro Asp Asn Glu Asp Leu Met Glu Glu 
            820                 825                 830         


Ile Val Lys Ile Leu Thr Val Phe Glu Asp Arg Lys Met Arg Arg Lys 
        835                 840                 845             


Gln Leu Glu Lys Tyr Lys Glu Arg Leu Ser Pro Glu Gln Ile Lys Glu 
    850                 855                 860                 


Leu Ala Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys Leu 
865                 870                 875                 880 


Leu Val Gly Ile Arg Asp Lys Glu Thr Gln Lys Thr Ile Leu Asp Tyr 
                885                 890                 895     


Leu Val Glu Asp Asp Asn His Ser Gly Gly Arg Gln His Leu Asn Arg 
            900                 905                 910         


Asn Leu Met Gln Leu Ile Asn Asp Asp Arg Leu Ser Phe Lys Lys Thr 
        915                 920                 925             


Ile Ala Glu Leu Gln Met Ile Asp Pro Ser Ala Asp Leu Tyr Ala Gln 
    930                 935                 940                 


Val Gln Glu Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Leu 
945                 950                 955                 960 


Gly Leu Lys Ile Val Asp Glu Ile Ile Arg Val Met Gly Glu Lys Pro 
                965                 970                 975     


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Arg 
            980                 985                 990         


Gly Lys Ala Leu Ser Lys Arg Arg  Glu Ala Lys Ile Lys  Glu Gly Leu 
        995                 1000                 1005             


Ala Ala  Leu Gly Ser Ser Leu  Leu Lys Glu Asn Leu  Pro Gly Asn 
    1010                 1015                 1020             


Ala Asp  Leu Ser Gln Arg Lys  Ile Tyr Leu Tyr Tyr  Thr Gln Asn 
    1025                 1030                 1035             


Gly Lys  Asp Ile Tyr Leu Asp  Glu Pro Leu Asp Phe  Asp Arg Leu 
    1040                 1045                 1050             


Ser Gln  Tyr Asp Glu Asp His  Ile Ile Pro Gln Ser  Phe Thr Val 
    1055                 1060                 1065             


Asp Asn  Ser Leu Asp Asn Leu  Val Leu Thr Asn Ser  Ser Gln Asn 
    1070                 1075                 1080             


Arg Gly  Asn Lys Lys Asp Asp  Val Pro Ser Leu Glu  Val Val Asn 
    1085                 1090                 1095             


Arg Gln  Leu Ala Tyr Trp Arg  Ser Leu Lys Asp Ala  Gly Leu Met 
    1100                 1105                 1110             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Met  Arg Gly Gly 
    1115                 1120                 1125             


Leu Thr  Asp Lys Asp Arg Glu  Arg Phe Ile Gln Arg  Gln Leu Val 
    1130                 1135                 1140             


Glu Thr  Arg Gln Ile Thr Lys  Asn Val Ala Lys Leu  Leu Asp Met 
    1145                 1150                 1155             


Arg Leu  Asn Asp Lys Lys Asp  Glu Ala Gly Asn Lys  Ile Arg Glu 
    1160                 1165                 1170             


Thr Asn  Ile Val Leu Leu Lys  Ser Ala Met Ala Ser  Glu Phe Arg 
    1175                 1180                 1185             


Lys Met  Phe Arg Leu Tyr Lys  Val Arg Glu Leu Asn  Asp Tyr His 
    1190                 1195                 1200             


His Ala  His Asp Ala Tyr Leu  Asn Ala Ala Ile Ala  Ile Asn Leu 
    1205                 1210                 1215             


Leu Ala  Leu Tyr Pro Tyr Met  Ala Asp Asp Phe Val  Tyr Gly Glu 
    1220                 1225                 1230             


Phe Arg  Tyr Lys Lys Lys Pro  Gln Ala Glu Lys Ala  Thr Tyr Glu 
    1235                 1240                 1245             


Lys Leu  Arg Gln Trp Asn Leu  Ile Lys Arg Phe Gly  Glu Lys Gln 
    1250                 1255                 1260             


Leu Phe  Thr Pro Asp His Glu  Asp Cys Trp Asn Lys  Glu Arg Asp 
    1265                 1270                 1275             


Ile Lys  Thr Ile Lys Lys Val  Met Gly Tyr Arg Gln  Val Asn Val 
    1280                 1285                 1290             


Val Lys  Lys Ala Glu Glu Arg  Thr Gly Met Leu Phe  Lys Glu Thr 
    1295                 1300                 1305             


Ile Asn  Gly Lys Thr Asn Lys  Gly Ser Arg Ile Pro  Ile Lys Lys 
    1310                 1315                 1320             


Asp Leu  Asp Pro Ser Lys Tyr  Gly Gly Tyr Ile Glu  Glu Lys Met 
    1325                 1330                 1335             


Ala Tyr  Tyr Ala Val Ile Ser  Tyr Glu Asp Lys Lys  Lys Lys Pro 
    1340                 1345                 1350             


Gly Lys  Thr Ile Val Gly Ile  Ser Ile Met Asp Lys  Lys Glu Phe 
    1355                 1360                 1365             


Glu Tyr  Asp Ser Ile Ser Tyr  Leu Gly Lys Leu Gly  Phe Ser Asn 
    1370                 1375                 1380             


Pro Val  Val Gln Ile Ile Leu  Lys Asn Tyr Ser Leu  Ile Ala Tyr 
    1385                 1390                 1395             


Pro Asp  Gly Arg Arg Arg Tyr  Ile Thr Gly Ala Thr  Lys Thr Thr 
    1400                 1405                 1410             


Lys Gly  Lys Val Glu Leu Gln  Lys Ala Asn Gln Ile  Ala Met Glu 
    1415                 1420                 1425             


Gln Asp  Leu Val Asn Phe Ile  Tyr His Leu Lys Asn  Tyr Asp Glu 
    1430                 1435                 1440             


Ile Ser  His Pro Glu Ser Tyr  Ala Phe Val Gln Ser  His Thr Asp 
    1445                 1450                 1455             


Tyr Phe  Asp Arg Leu Phe Asp  Ser Ile Glu His Tyr  Thr Arg Arg 
    1460                 1465                 1470             


Phe Leu  Asp Ala Glu Thr Asn  Ile Asn Arg Leu Arg  Arg Ile Tyr 
    1475                 1480                 1485             


Glu Glu  Glu Lys Lys Lys Asp  Pro Val Asp Ile Glu  Ala Leu Val 
    1490                 1495                 1500             


Ala Ser  Phe Ile Glu Leu Leu  Lys Leu Thr Ser Ala  Gly Ala Pro 
    1505                 1510                 1515             


Ala Asp  Phe Ile Phe Met Gly  Glu Ala Ile Ser Arg  Arg Arg Tyr 
    1520                 1525                 1530             


Asn Ser  Met Thr Gly Leu Phe  Asp Gly Gln Val Ile  Tyr Gln Ser 
    1535                 1540                 1545             


Leu Thr  Gly Leu Tyr Glu Thr  Arg Met Arg Phe Glu  Asp Lys Arg 
    1550                 1555                 1560             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys Gly 
    1565                 1570                 1575             


Ser Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1580                 1585                 1590             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Glu Lys  Gly Pro Ser Thr Gly  Asp Pro Thr 
    1610                 1615                 1620             


Leu Arg  Arg Arg Ile Glu Ser  Trp Glu Phe Asp Val  Phe Tyr Asp 
    1625                 1630                 1635             


Pro Arg  Glu Leu Arg Lys Glu  Thr Cys Leu Leu Tyr  Glu Ile Lys 
    1640                 1645                 1650             


Trp Gly  Met Ser Arg Lys Ile  Trp Arg Ser Ser Gly  Lys Asn Thr 
    1655                 1660                 1665             


Thr Asn  His Val Glu Val Asn  Phe Ile Lys Lys Phe  Thr Ser Glu 
    1670                 1675                 1680             


Arg Arg  Phe His Ser Ser Ile  Ser Cys Ser Ile Thr  Trp Phe Leu 
    1685                 1690                 1695             


Ser Trp  Ser Pro Cys Trp Glu  Cys Ser Gln Ala Ile  Arg Glu Phe 
    1700                 1705                 1710             


Leu Ser  Gln His Pro Gly Val  Thr Leu Val Ile Tyr  Val Ala Arg 
    1715                 1720                 1725             


Leu Phe  Trp His Met Asp Gln  Arg Asn Arg Gln Gly  Leu Arg Asp 
    1730                 1735                 1740             


Leu Val  Asn Ser Gly Val Thr  Ile Gln Ile Met Arg  Ala Ser Glu 
    1745                 1750                 1755             


Tyr Tyr  His Cys Trp Arg Asn  Phe Val Asn Tyr Pro  Pro Gly Asp 
    1760                 1765                 1770             


Glu Ala  His Trp Pro Gln Tyr  Pro Pro Leu Trp Met  Met Leu Tyr 
    1775                 1780                 1785             


Ala Leu  Glu Leu His Cys Ile  Ile Leu Ser Leu Pro  Pro Cys Leu 
    1790                 1795                 1800             


Lys Ile  Ser Arg Arg Trp Gln  Asn His Leu Ala Phe  Phe Arg Leu 
    1805                 1810                 1815             


His Leu  Gln Asn Cys His Tyr  Gln Thr Ile Pro Pro  His Ile Leu 
    1820                 1825                 1830             


Leu Ala  Thr Gly Leu Ile His  Pro Ser Val Thr Trp  Arg Tyr Pro 
    1835                 1840                 1845             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1850                 1855                 1860             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1865                 1870             


<210> 95
<211> 125
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 95
gucuuggaug agugugaaaa cacucauagu caagaucaaa cgagugguuu uccacgaguu       60

auuacuuuug aggucuuaua uggcccauac auaaaaagga gucggaauuu ccggcuccuu      120

uucuu                                                                  125


<210> 96
<211> 88
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
guuuuagagc cauguagaaa uacauugcaa guuaaaauaa ggcuuugucc guaaucaacu       60

ugaaaaagug gcgcuguuuc ggcgcuuu                                          88


<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 97
gaaacaatga taacaagacc                                                   20


<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
gtggcccctg tgcccagccc                                                   20


<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
gtcccaaata tgtagctgtt                                                   20


<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
gctcccatca catcaaccgg                                                   20


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
gatgtcacct ccaatgacta                                                   20


<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gttgaagatg aagcccagag                                                   20


<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
gccaacacca accagaactt                                                   20


<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
tgctgcacac agcaggcctt                                                   20


<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
gaacacaaag catagactgc                                                   20


<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
gaaacaatga taacaagacc                                                   20


<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
gtggcccctg tgcccagccc                                                   20


<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
gtcccaaata tgtagctgtt                                                   20


<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
agagggacac acagatctat                                                   20


<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
gctcccatca catcaaccgg                                                   20


<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
gatgtcacct ccaatgacta                                                   20


<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
gggcaaccac aaacccacga                                                   20


<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gttgaagatg aagcccagag                                                   20


<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
gccaacacca accagaactt                                                   20


<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
tgctgcacac agcaggcctt                                                   20


<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
gtgccagaaa caggggtgac                                                   20


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
cctgcctcag ctgctcactt                                                   20


<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
aaacggtccc cagagggttc                                                   20


<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 119
gccaccggtt gatgtgatgg                                                   20


<210> 120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
aagtggtccc aggcctcagc                                                   20


<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
agagaaaatg aaactttcaa                                                   20


<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 122
ccaaacccaa ctccatctac                                                   20


<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 123
ggtccttgaa ttgcagtatc                                                   20


<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
gcatagactg cggggcgggc                                                   20


<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 125
ggaaactgga acacaaagca                                                   20


<210> 126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 126
gacagcatgt ggtaattttc                                                   20


<210> 127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 127
gcccccggaa actctgtcca                                                   20


<210> 128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
tcgaccccca ccaaggttca                                                   20


<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 129
tgttaacagc tgacccaata                                                   20


<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 130
gttactcgcc tgtcaagtgg                                                   20


<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 131
gggctcccat cacatcaacc                                                   20


<210> 132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
gctttgggga ggcctggagt                                                   20


<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 133
tagctgccaa tgactatagc                                                   20


<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 134
ttaaaatagg atctacatca                                                   20


<210> 135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 135
gaatcctgcc atacactttg                                                   20


<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 136
ctgcggggcg ggccagcctg                                                   20


<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 137
acattgtcag agggacacac                                                   20


<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 138
agcaactcca gtcccaaata                                                   20


<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 139
gtggtggccg agcgccccct                                                   20


<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 140
cattcaccca gcttccctgt                                                   20


<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 141
gaacacaaag catagactgc                                                   20


<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 142
gaaacaatga taacaagacc                                                   20


<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 143
gtggcccctg tgcccagccc                                                   20


<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 144
gtcccaaata tgtagctgtt                                                   20


<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 145
agagggacac acagatctat                                                   20


<210> 146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 146
gctcccatca catcaaccgg                                                   20


<210> 147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 147
gatgtcacct ccaatgacta                                                   20


<210> 148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 148
gggcaaccac aaacccacga                                                   20


<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 149
gttgaagatg aagcccagag                                                   20


<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 150
gccaacacca accagaactt                                                   20


<210> 151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 151
tgctgcacac agcaggcctt                                                   20


<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 152
gtgccagaaa caggggtgac                                                   20


<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 153
tcacggagac tgaacactcc                                                   20


<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 154
gtaacagaca tggaccatca                                                   20


<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 155
gggagggagg ggcacagatg                                                   20


<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 156
tgtggttcca gaaccggagg                                                   20


<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 157
aatgagagaa aatgaaactt                                                   20


<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 158
ggccatcaag gatgcccacg                                                   20


<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 159
aaattgtcca gccccatctg                                                   20


<210> 160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 160
cctgtaaagg aaactggaac                                                   20


<210> 161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 161
tacatgaagc aactccagtc                                                   20


<210> 162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 162
aaactccccc cacccccttt                                                   20


<210> 163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 163
gagttgggtt tggtgctcaa                                                   20


<210> 164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 164
gcgggccagc ctgaatagct                                                   20


<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 165
gaaacaatga taacaagacc                                                   20


<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 166
gtggcccctg tgcccagccc                                                   20


<210> 167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 167
gtcccaaata tgtagctgtt                                                   20


<210> 168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 168
gctcccatca catcaaccgg                                                   20


<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 169
gatgtcacct ccaatgacta                                                   20


<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 170
gttgaagatg aagcccagag                                                   20


<210> 171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 171
gccaacacca accagaactt                                                   20


<210> 172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 172
tgctgcacac agcaggcctt                                                   20


<210> 173
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 173
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 174
<211> 60
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 174
guuuuagagc ugugcuguuu aaacaacaca gcaaguuaaa auaaggcuuu guccguacuc       60


<210> 175
<211> 1377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 175
Met Pro Lys Lys Lys Arg Lys Val Gly Met Gly Lys Pro Tyr Ser Ile 
1               5                   10                  15      


Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
            20                  25                  30          


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
        35                  40                  45              


Lys Gln Ser Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
    50                  55                  60                  


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
65                  70                  75                  80  


Tyr Thr Arg Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu Ile Phe Thr 
                85                  90                  95      


Gly Glu Met Asn Lys Val Asp Glu Asn Phe Phe Gln Arg Leu Asp Asp 
            100                 105                 110         


Ser Phe Leu Val Asp Glu Asp Lys Arg Gly Glu His His Pro Ile Phe 
        115                 120                 125             


Gly Asn Ile Ala Ala Glu Val Lys Tyr His Asp Asp Phe Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Arg His Leu Ala Asp Thr Ser Lys Lys Ala Asp Leu 
145                 150                 155                 160 


Arg Leu Val Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                165                 170                 175     


Phe Leu Tyr Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp Val Gln Ala 
            180                 185                 190         


Leu Phe Lys Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile Glu Glu Ser 
        195                 200                 205             


His Leu Ser Glu Ile Thr Val Asp Ala Leu Ser Ile Leu Thr Glu Lys 
    210                 215                 220                 


Val Ser Lys Ser Ser Arg Leu Glu Asn Leu Ile Ala His Tyr Pro Thr 
225                 230                 235                 240 


Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Asp 
                245                 250                 255     


Leu His Pro Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu Asp Ala Lys 
            260                 265                 270         


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu Gly Phe Leu 
        275                 280                 285             


Gly Glu Val Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser Ala Lys Asn 
    290                 295                 300                 


Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu Thr Val Asp Asp Asn 
305                 310                 315                 320 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Glu Glu 
                325                 330                 335     


His Gln Lys Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys Val Asn Ala 
            340                 345                 350         


Pro Asp Gln Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys Lys Gly Tyr 
        355                 360                 365             


Ala Ser Tyr Ile Glu Ser Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr 
    370                 375                 380                 


Leu Lys Gly Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp Phe Leu Asp 
385                 390                 395                 400 


Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile Leu 
            420                 425                 430         


Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp Lys 
        435                 440                 445             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    450                 455                 460                 


Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp Glu 
465                 470                 475                 480 


Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys Ser 
                485                 490                 495     


Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro 
            500                 505                 510         


Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Ala Phe Thr 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly Glu 
    530                 535                 540                 


Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His Val 
545                 550                 555                 560 


Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr Leu 
                565                 570                 575     


Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu Asp 
            580                 585                 590         


Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr His Asp Leu 
        595                 600                 605             


Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala Asn Glu Lys 
    610                 615                 620                 


Thr Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys Ala 
                645                 650                 655     


Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys Thr 
        675                 680                 685             


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Arg 
705                 710                 715                 720 


Ala Gln Ile Ile Asp Asp Val Asp Asp Ile Ala Asn Val Val His Asp 
                725                 730                 735     


Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn Ile 
        755                 760                 765             


Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg Arg 
    770                 775                 780                 


Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn Leu 
785                 790                 795                 800 


Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln Asn 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu Ser 
                885                 890                 895     


Val Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Glu Arg Phe Asn Thr Glu Phe Asp Gly Asn Lys Arg Arg Ile Arg Asn 
945                 950                 955                 960 


Val Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys 
                965                 970                 975     


Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Asn Ala Leu  Leu Leu Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Glu Pro Glu  Phe Val Tyr Gly Glu  Tyr Pro Lys 
    1010                 1015                 1020             


Tyr Asn  Ser Tyr Arg Ser Arg  Lys Ser Ala Thr Glu  Lys Phe Leu 
    1025                 1030                 1035             


Phe Tyr  Ser Asn Ile Leu Arg  Phe Phe Lys Lys Glu  Asp Ile Gln 
    1040                 1045                 1050             


Thr Asn  Glu Asp Gly Glu Ile  Ala Trp Asn Lys Glu  Lys His Ile 
    1055                 1060                 1065             


Lys Ile  Leu Arg Lys Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val 
    1070                 1075                 1080             


Lys Lys  Thr Glu Glu Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1085                 1090                 1095             


Leu Pro  Lys Gly Glu Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys 
    1100                 1105                 1110             


Asn Ser  Tyr Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Met Gln Pro 
    1115                 1120                 1125             


Val Val  Ala Tyr Ser Ile Leu  Val Phe Ala Asp Val  Glu Lys Gly 
    1130                 1135                 1140             


Lys Ser  Lys Lys Leu Arg Lys  Val Gln Asp Met Val  Gly Ile Thr 
    1145                 1150                 1155             


Ile Met  Glu Lys Lys Arg Phe  Glu Lys Asn Pro Val  Asp Phe Leu 
    1160                 1165                 1170             


Glu Gln  Arg Gly Tyr Arg Asn  Val Arg Leu Glu Lys  Ile Ile Lys 
    1175                 1180                 1185             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Lys  Arg Arg Arg 
    1190                 1195                 1200             


Leu Leu  Ala Ser Ala Lys Phe  Leu Gln Lys Gly Asn  Glu Leu Val 
    1205                 1210                 1215             


Ile Pro  Gln Arg Phe Thr Thr  Leu Leu Tyr His Ser  Tyr Arg Ile 
    1220                 1225                 1230             


Glu Lys  Asp Tyr Glu Pro Glu  His Arg Glu Tyr Val  Glu Lys His 
    1235                 1240                 1245             


Lys Asp  Glu Phe Lys Glu Leu  Leu Glu Tyr Ile Ser  Val Phe Ser 
    1250                 1255                 1260             


Arg Lys  Tyr Val Leu Ala Asp  Asn Asn Leu Thr Lys  Ile Glu Met 
    1265                 1270                 1275             


Leu Phe  Ser Lys Asn Lys Asp  Ala Glu Val Ser Ser  Leu Ala Lys 
    1280                 1285                 1290             


Ser Phe  Ile Ser Leu Leu Thr  Phe Thr Ala Phe Gly  Ala Pro Arg 
    1295                 1300                 1305             


Ala Phe  Asn Phe Phe Gly Glu  Asn Ile Ala Arg Lys  Glu Tyr Arg 
    1310                 1315                 1320             


Ser Val  Thr Glu Cys Leu Asn  Ala Thr Leu Ile His  Gln Ser Ile 
    1325                 1330                 1335             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Lys  Leu Gly Glu 
    1340                 1345                 1350             


Asp Gly  Glu Gly Ala Asp Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1355                 1360                 1365             


Glu Ser  Pro Lys Lys Lys Arg  Lys Val 
    1370                 1375         


<210> 176
<211> 1377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 176
Met Pro Lys Lys Lys Arg Lys Val Gly Met Gly Lys Pro Tyr Ser Ile 
1               5                   10                  15      


Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
            20                  25                  30          


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
        35                  40                  45              


Lys Gln Ser Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
    50                  55                  60                  


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
65                  70                  75                  80  


Tyr Thr Arg Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu Ile Phe Thr 
                85                  90                  95      


Gly Glu Met Asn Lys Val Asp Glu Asn Phe Phe Gln Arg Leu Asp Asp 
            100                 105                 110         


Ser Phe Leu Val Asp Glu Asp Lys Arg Gly Glu His His Pro Ile Phe 
        115                 120                 125             


Gly Asn Ile Ala Ala Glu Val Lys Tyr His Asp Asp Phe Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Arg His Leu Ala Asp Thr Ser Lys Lys Ala Asp Leu 
145                 150                 155                 160 


Arg Leu Val Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                165                 170                 175     


Phe Leu Tyr Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp Val Gln Ala 
            180                 185                 190         


Leu Phe Lys Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile Glu Glu Ser 
        195                 200                 205             


His Leu Ser Glu Ile Thr Val Asp Ala Leu Ser Ile Leu Thr Glu Lys 
    210                 215                 220                 


Val Ser Lys Ser Ser Arg Leu Glu Asn Leu Ile Ala His Tyr Pro Thr 
225                 230                 235                 240 


Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Asp 
                245                 250                 255     


Leu His Pro Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu Asp Ala Lys 
            260                 265                 270         


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu Gly Phe Leu 
        275                 280                 285             


Gly Glu Val Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser Ala Lys Asn 
    290                 295                 300                 


Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu Thr Val Asp Asp Asn 
305                 310                 315                 320 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Glu Glu 
                325                 330                 335     


His Gln Lys Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys Val Asn Ala 
            340                 345                 350         


Pro Asp Gln Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys Lys Gly Tyr 
        355                 360                 365             


Ala Ser Tyr Ile Glu Ser Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr 
    370                 375                 380                 


Leu Lys Gly Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp Phe Leu Asp 
385                 390                 395                 400 


Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ile Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile Leu 
            420                 425                 430         


Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp Lys 
        435                 440                 445             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    450                 455                 460                 


Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp Glu 
465                 470                 475                 480 


Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys Ser 
                485                 490                 495     


Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro 
            500                 505                 510         


Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Ala Phe Thr 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly Glu 
    530                 535                 540                 


Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His Val 
545                 550                 555                 560 


Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr Leu 
                565                 570                 575     


Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu Asp 
            580                 585                 590         


Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr His Asp Leu 
        595                 600                 605             


Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala Asn Glu Lys 
    610                 615                 620                 


Thr Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys Ala 
                645                 650                 655     


Gln Leu Lys Lys Leu Glu Arg Leu His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys Thr 
        675                 680                 685             


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Arg 
705                 710                 715                 720 


Ala Gln Ile Ile Asp Asp Val Asp Asp Ile Ala Asn Val Val His Asp 
                725                 730                 735     


Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn Ile 
        755                 760                 765             


Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg Arg 
    770                 775                 780                 


Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn Leu 
785                 790                 795                 800 


Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln Asn 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu Ser 
                885                 890                 895     


Val Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Glu Arg Phe Asn Thr Glu Phe Asp Gly Asn Lys Arg Arg Ile Arg Asn 
945                 950                 955                 960 


Val Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys 
                965                 970                 975     


Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Asn Ala Leu  Leu Leu Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Glu Pro Glu  Phe Val Tyr Gly Glu  Tyr Pro Lys 
    1010                 1015                 1020             


Tyr Asn  Ser Tyr Arg Ser Arg  Lys Ser Ala Thr Glu  Lys Phe Leu 
    1025                 1030                 1035             


Phe Tyr  Ser Asn Ile Leu Arg  Phe Phe Lys Lys Glu  Asp Ile Gln 
    1040                 1045                 1050             


Thr Asn  Glu Asp Gly Glu Ile  Ala Trp Asn Lys Glu  Lys His Ile 
    1055                 1060                 1065             


Lys Ile  Leu Arg Lys Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val 
    1070                 1075                 1080             


Lys Lys  Thr Glu Glu Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1085                 1090                 1095             


Leu Pro  Lys Gly Glu Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys 
    1100                 1105                 1110             


Asn Ser  Tyr Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Met Gln Pro 
    1115                 1120                 1125             


Val Val  Ala Tyr Ser Ile Leu  Val Phe Ala Asp Val  Glu Lys Gly 
    1130                 1135                 1140             


Lys Ser  Lys Lys Leu Arg Lys  Val Gln Asp Met Val  Gly Ile Thr 
    1145                 1150                 1155             


Ile Met  Glu Lys Lys Arg Phe  Glu Lys Asn Pro Val  Asp Phe Leu 
    1160                 1165                 1170             


Glu Gln  Arg Gly Tyr Arg Asn  Val Arg Leu Glu Lys  Ile Ile Lys 
    1175                 1180                 1185             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Lys  Arg Arg Arg 
    1190                 1195                 1200             


Leu Leu  Ala Ser Ala Lys Phe  Leu Gln Lys Gly Asn  Glu Leu Val 
    1205                 1210                 1215             


Ile Pro  Gln Arg Phe Thr Thr  Leu Leu Tyr His Ser  Tyr Arg Ile 
    1220                 1225                 1230             


Glu Lys  Asp Tyr Glu Pro Glu  His Arg Glu Tyr Val  Glu Lys His 
    1235                 1240                 1245             


Lys Asp  Glu Phe Lys Glu Leu  Leu Glu Tyr Ile Ser  Val Phe Ser 
    1250                 1255                 1260             


Arg Lys  Tyr Val Leu Ala Asp  Asn Asn Leu Thr Lys  Ile Glu Met 
    1265                 1270                 1275             


Leu Phe  Ser Lys Asn Lys Asp  Ala Glu Val Ser Ser  Leu Ala Lys 
    1280                 1285                 1290             


Ser Phe  Ile Ser Leu Leu Thr  Phe Thr Ala Phe Gly  Ala Pro Arg 
    1295                 1300                 1305             


Ala Phe  Asn Phe Phe Gly Glu  Asn Ile Ala Arg Lys  Glu Tyr Arg 
    1310                 1315                 1320             


Ser Val  Thr Glu Cys Leu Asn  Ala Thr Leu Ile His  Gln Ser Ile 
    1325                 1330                 1335             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Lys  Leu Gly Glu 
    1340                 1345                 1350             


Asp Gly  Glu Gly Ala Asp Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1355                 1360                 1365             


Glu Ser  Pro Lys Lys Lys Arg  Lys Val 
    1370                 1375         


<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 177
atcgacaaga aagggactga                                                   20


<210> 178
<211> 1566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 178
Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Ser Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Arg Phe Phe Arg Met Pro Arg Arg Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Gly Lys Pro Tyr Ser Ile Gly Leu Ala 
        195                 200                 205             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp Asp Tyr Lys 
    210                 215                 220                 


Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp Lys Gln Ser 
225                 230                 235                 240 


Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                245                 250                 255     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            260                 265                 270         


Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met 
        275                 280                 285             


Asn Lys Val Asp Glu Asn Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu 
    290                 295                 300                 


Val Asp Glu Asp Lys Arg Gly Glu His His Pro Ile Phe Gly Asn Ile 
305                 310                 315                 320 


Ala Ala Glu Val Lys Tyr His Asp Asp Phe Pro Thr Ile Tyr His Leu 
                325                 330                 335     


Arg Arg His Leu Ala Asp Thr Ser Lys Lys Ala Asp Leu Arg Leu Val 
            340                 345                 350         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Tyr 
        355                 360                 365             


Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp Val Gln Ala Leu Phe Lys 
    370                 375                 380                 


Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile Glu Glu Ser His Leu Ser 
385                 390                 395                 400 


Glu Ile Thr Val Asp Ala Leu Ser Ile Leu Thr Glu Lys Val Ser Lys 
                405                 410                 415     


Ser Ser Arg Leu Glu Asn Leu Ile Ala His Tyr Pro Thr Glu Lys Lys 
            420                 425                 430         


Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Asp Leu His Pro 
        435                 440                 445             


Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe 
    450                 455                 460                 


Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu Gly Phe Leu Gly Glu Val 
465                 470                 475                 480 


Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp 
                485                 490                 495     


Ala Ile Leu Leu Ser Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys 
            500                 505                 510         


Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Glu Glu His Gln Lys 
        515                 520                 525             


Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys Val Asn Ala Pro Asp Gln 
    530                 535                 540                 


Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr 
545                 550                 555                 560 


Ile Glu Ser Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly 
                565                 570                 575     


Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp 
            580                 585                 590         


Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
        595                 600                 605             


Pro His Gln Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln 
    610                 615                 620                 


Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys 
625                 630                 635                 640 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys 
                645                 650                 655     


Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr 
            660                 665                 670         


Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys 
        675                 680                 685             


Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys 
    690                 695                 700                 


Val Leu Pro Lys His Ser Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn 
705                 710                 715                 720 


Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe 
                725                 730                 735     


Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu 
            740                 745                 750         


Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu 
        755                 760                 765             


Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu Asp Lys Glu Asn 
    770                 775                 780                 


Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr His Asp Leu Arg Lys Ile 
785                 790                 795                 800 


Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu 
                805                 810                 815     


Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Arg 
            820                 825                 830         


Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys 
        835                 840                 845             


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys 
    850                 855                 860                 


Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp 
865                 870                 875                 880 


Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile 
                885                 890                 895     


Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile 
            900                 905                 910         


Ile Asp Asp Val Asp Asp Ile Ala Asn Val Val His Asp Leu Pro Gly 
        915                 920                 925             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp 
    930                 935                 940                 


Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn Ile Ile Ile Glu 
945                 950                 955                 960 


Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln 
                965                 970                 975     


Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro 
            980                 985                 990         


Val Asn Ile Lys Asn Val Glu Asn  Gln Gln Leu Gln Asn  Asp Arg Leu 
        995                 1000                 1005             


Phe Leu  Tyr Tyr Ile Gln Asn  Gly Lys Asp Met Tyr  Thr Gly Glu 
    1010                 1015                 1020             


Thr Leu  Asp Ile Asn Asn Leu  Ser Gln Tyr Asp Ile  Asp His Ile 
    1025                 1030                 1035             


Ile Pro  Gln Ala Phe Ile Lys  Asp Asn Ser Leu Asp  Asn Arg Val 
    1040                 1045                 1050             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asp Val Pro 
    1055                 1060                 1065             


Ser Ile  Glu Val Val His Glu  Met Lys Ser Phe Trp  Ser Lys Leu 
    1070                 1075                 1080             


Leu Ser  Val Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1085                 1090                 1095             


Lys Ala  Glu Arg Gly Gly Leu  Thr Glu Glu Asp Lys  Ala Gly Phe 
    1100                 1105                 1110             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1115                 1120                 1125             


Ala Gln  Ile Leu Asp Glu Arg  Phe Asn Thr Glu Phe  Asp Gly Asn 
    1130                 1135                 1140             


Lys Arg  Arg Ile Arg Asn Val  Lys Ile Ile Thr Leu  Lys Ser Asn 
    1145                 1150                 1155             


Leu Val  Ser Asn Phe Arg Lys  Glu Phe Glu Leu Tyr  Lys Val Arg 
    1160                 1165                 1170             


Glu Ile  Asn Asp Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1175                 1180                 1185             


Val Val  Gly Asn Ala Leu Leu  Leu Lys Tyr Pro Gln  Leu Glu Pro 
    1190                 1195                 1200             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Ser 
    1205                 1210                 1215             


Arg Lys  Ser Ala Thr Glu Lys  Phe Leu Phe Tyr Ser  Asn Ile Leu 
    1220                 1225                 1230             


Arg Phe  Phe Lys Lys Glu Asp  Ile Gln Thr Asn Glu  Asp Gly Glu 
    1235                 1240                 1245             


Ile Ala  Trp Asn Lys Glu Lys  His Ile Lys Ile Leu  Arg Lys Val 
    1250                 1255                 1260             


Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln 
    1265                 1270                 1275             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Gly Glu Ser 
    1280                 1285                 1290             


Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Asn Ser Tyr  Trp Asp Pro 
    1295                 1300                 1305             


Lys Lys  Tyr Gly Gly Phe Met  Gln Pro Val Val Ala  Tyr Ser Ile 
    1310                 1315                 1320             


Leu Val  Phe Ala Asp Val Glu  Lys Gly Lys Ser Lys  Lys Leu Arg 
    1325                 1330                 1335             


Lys Val  Gln Asp Met Val Gly  Ile Thr Ile Met Glu  Lys Lys Arg 
    1340                 1345                 1350             


Phe Glu  Lys Asn Pro Val Asp  Phe Leu Glu Gln Arg  Gly Tyr Arg 
    1355                 1360                 1365             


Asn Val  Arg Leu Glu Lys Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1370                 1375                 1380             


Phe Glu  Leu Glu Asn Lys Arg  Arg Arg Leu Leu Ala  Ser Ala Lys 
    1385                 1390                 1395             


Phe Leu  Gln Lys Gly Asn Glu  Leu Val Ile Pro Gln  Arg Phe Thr 
    1400                 1405                 1410             


Thr Leu  Leu Tyr His Ser Tyr  Arg Ile Glu Lys Asp  Tyr Glu Pro 
    1415                 1420                 1425             


Glu His  Arg Glu Tyr Val Glu  Lys His Lys Asp Glu  Phe Lys Glu 
    1430                 1435                 1440             


Leu Leu  Glu Tyr Ile Ser Val  Phe Ser Arg Lys Tyr  Val Leu Ala 
    1445                 1450                 1455             


Asp Asn  Asn Leu Thr Lys Ile  Glu Met Leu Phe Ser  Lys Asn Lys 
    1460                 1465                 1470             


Asp Ala  Glu Val Ser Ser Leu  Ala Lys Ser Phe Ile  Ser Leu Leu 
    1475                 1480                 1485             


Thr Phe  Thr Ala Phe Gly Ala  Pro Arg Ala Phe Asn  Phe Phe Gly 
    1490                 1495                 1500             


Glu Asn  Ile Ala Arg Lys Glu  Tyr Arg Ser Val Thr  Glu Cys Leu 
    1505                 1510                 1515             


Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1520                 1525                 1530             


Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asp Gly Glu  Gly Ala Asp 
    1535                 1540                 1545             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Ser Pro  Lys Lys Lys 
    1550                 1555                 1560             


Arg Lys  Val 
    1565     


<210> 179
<211> 1566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 179
Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Ser Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Arg Phe Phe Arg Met Pro Arg Arg Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Gly Lys Pro Tyr Ser Ile Gly Leu Ala 
        195                 200                 205             


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp Asp Tyr Lys 
    210                 215                 220                 


Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp Lys Gln Ser 
225                 230                 235                 240 


Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
                245                 250                 255     


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
            260                 265                 270         


Arg Lys Asn Arg Leu Arg Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met 
        275                 280                 285             


Asn Lys Val Asp Glu Asn Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu 
    290                 295                 300                 


Val Asp Glu Asp Lys Arg Gly Glu His His Pro Ile Phe Gly Asn Ile 
305                 310                 315                 320 


Ala Ala Glu Val Lys Tyr His Asp Asp Phe Pro Thr Ile Tyr His Leu 
                325                 330                 335     


Arg Arg His Leu Ala Asp Thr Ser Lys Lys Ala Asp Leu Arg Leu Val 
            340                 345                 350         


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Tyr 
        355                 360                 365             


Glu Gly Asp Leu Lys Ala Glu Asn Thr Asp Val Gln Ala Leu Phe Lys 
    370                 375                 380                 


Asp Phe Val Glu Glu Tyr Asp Lys Thr Ile Glu Glu Ser His Leu Ser 
385                 390                 395                 400 


Glu Ile Thr Val Asp Ala Leu Ser Ile Leu Thr Glu Lys Val Ser Lys 
                405                 410                 415     


Ser Ser Arg Leu Glu Asn Leu Ile Ala His Tyr Pro Thr Glu Lys Lys 
            420                 425                 430         


Asn Thr Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Asp Leu His Pro 
        435                 440                 445             


Asn Phe Lys Thr Asn Phe Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe 
    450                 455                 460                 


Ser Lys Asp Thr Tyr Glu Glu Asp Leu Glu Gly Phe Leu Gly Glu Val 
465                 470                 475                 480 


Gly Asp Glu Tyr Ala Asp Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp 
                485                 490                 495     


Ala Ile Leu Leu Ser Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys 
            500                 505                 510         


Ala Pro Leu Ser Ala Ser Met Val Lys Arg Tyr Glu Glu His Gln Lys 
        515                 520                 525             


Asp Leu Lys Lys Leu Lys Asp Phe Ile Lys Val Asn Ala Pro Asp Gln 
    530                 535                 540                 


Tyr Asn Ala Ile Phe Lys Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr 
545                 550                 555                 560 


Ile Glu Ser Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly 
                565                 570                 575     


Ile Leu Leu Lys Ile Asn Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp 
            580                 585                 590         


Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ile Ile 
        595                 600                 605             


Pro His Gln Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln 
    610                 615                 620                 


Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys 
625                 630                 635                 640 


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys 
                645                 650                 655     


Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr 
            660                 665                 670         


Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys 
        675                 680                 685             


Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys 
    690                 695                 700                 


Val Leu Pro Lys His Ser Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn 
705                 710                 715                 720 


Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe 
                725                 730                 735     


Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu 
            740                 745                 750         


Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu 
        755                 760                 765             


Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu Asp Lys Glu Asn 
    770                 775                 780                 


Lys Ala Phe Asn Ser Ser Leu Gly Thr Tyr His Asp Leu Arg Lys Ile 
785                 790                 795                 800 


Leu Asp Lys Ser Phe Leu Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu 
                805                 810                 815     


Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Arg 
            820                 825                 830         


Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys 
        835                 840                 845             


Lys Leu Glu Arg Leu His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys 
    850                 855                 860                 


Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp 
865                 870                 875                 880 


Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile 
                885                 890                 895     


Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile 
            900                 905                 910         


Ile Asp Asp Val Asp Asp Ile Ala Asn Val Val His Asp Leu Pro Gly 
        915                 920                 925             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp 
    930                 935                 940                 


Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn Ile Ile Ile Glu 
945                 950                 955                 960 


Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln 
                965                 970                 975     


Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro 
            980                 985                 990         


Val Asn Ile Lys Asn Val Glu Asn  Gln Gln Leu Gln Asn  Asp Arg Leu 
        995                 1000                 1005             


Phe Leu  Tyr Tyr Ile Gln Asn  Gly Lys Asp Met Tyr  Thr Gly Glu 
    1010                 1015                 1020             


Thr Leu  Asp Ile Asn Asn Leu  Ser Gln Tyr Asp Ile  Asp His Ile 
    1025                 1030                 1035             


Ile Pro  Gln Ala Phe Ile Lys  Asp Asn Ser Leu Asp  Asn Arg Val 
    1040                 1045                 1050             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asp Val Pro 
    1055                 1060                 1065             


Ser Ile  Glu Val Val His Glu  Met Lys Ser Phe Trp  Ser Lys Leu 
    1070                 1075                 1080             


Leu Ser  Val Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1085                 1090                 1095             


Lys Ala  Glu Arg Gly Gly Leu  Thr Glu Glu Asp Lys  Ala Gly Phe 
    1100                 1105                 1110             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1115                 1120                 1125             


Ala Gln  Ile Leu Asp Glu Arg  Phe Asn Thr Glu Phe  Asp Gly Asn 
    1130                 1135                 1140             


Lys Arg  Arg Ile Arg Asn Val  Lys Ile Ile Thr Leu  Lys Ser Asn 
    1145                 1150                 1155             


Leu Val  Ser Asn Phe Arg Lys  Glu Phe Glu Leu Tyr  Lys Val Arg 
    1160                 1165                 1170             


Glu Ile  Asn Asp Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1175                 1180                 1185             


Val Val  Gly Asn Ala Leu Leu  Leu Lys Tyr Pro Gln  Leu Glu Pro 
    1190                 1195                 1200             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Ser 
    1205                 1210                 1215             


Arg Lys  Ser Ala Thr Glu Lys  Phe Leu Phe Tyr Ser  Asn Ile Leu 
    1220                 1225                 1230             


Arg Phe  Phe Lys Lys Glu Asp  Ile Gln Thr Asn Glu  Asp Gly Glu 
    1235                 1240                 1245             


Ile Ala  Trp Asn Lys Glu Lys  His Ile Lys Ile Leu  Arg Lys Val 
    1250                 1255                 1260             


Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln 
    1265                 1270                 1275             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Gly Glu Ser 
    1280                 1285                 1290             


Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Asn Ser Tyr  Trp Asp Pro 
    1295                 1300                 1305             


Lys Lys  Tyr Gly Gly Phe Met  Gln Pro Val Val Ala  Tyr Ser Ile 
    1310                 1315                 1320             


Leu Val  Phe Ala Asp Val Glu  Lys Gly Lys Ser Lys  Lys Leu Arg 
    1325                 1330                 1335             


Lys Val  Gln Asp Met Val Gly  Ile Thr Ile Met Glu  Lys Lys Arg 
    1340                 1345                 1350             


Phe Glu  Lys Asn Pro Val Asp  Phe Leu Glu Gln Arg  Gly Tyr Arg 
    1355                 1360                 1365             


Asn Val  Arg Leu Glu Lys Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1370                 1375                 1380             


Phe Glu  Leu Glu Asn Lys Arg  Arg Arg Leu Leu Ala  Ser Ala Lys 
    1385                 1390                 1395             


Phe Leu  Gln Lys Gly Asn Glu  Leu Val Ile Pro Gln  Arg Phe Thr 
    1400                 1405                 1410             


Thr Leu  Leu Tyr His Ser Tyr  Arg Ile Glu Lys Asp  Tyr Glu Pro 
    1415                 1420                 1425             


Glu His  Arg Glu Tyr Val Glu  Lys His Lys Asp Glu  Phe Lys Glu 
    1430                 1435                 1440             


Leu Leu  Glu Tyr Ile Ser Val  Phe Ser Arg Lys Tyr  Val Leu Ala 
    1445                 1450                 1455             


Asp Asn  Asn Leu Thr Lys Ile  Glu Met Leu Phe Ser  Lys Asn Lys 
    1460                 1465                 1470             


Asp Ala  Glu Val Ser Ser Leu  Ala Lys Ser Phe Ile  Ser Leu Leu 
    1475                 1480                 1485             


Thr Phe  Thr Ala Phe Gly Ala  Pro Arg Ala Phe Asn  Phe Phe Gly 
    1490                 1495                 1500             


Glu Asn  Ile Ala Arg Lys Glu  Tyr Arg Ser Val Thr  Glu Cys Leu 
    1505                 1510                 1515             


Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1520                 1525                 1530             


Arg Ile  Asp Leu Ser Lys Leu  Gly Glu Asp Gly Glu  Gly Ala Asp 
    1535                 1540                 1545             


Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu Ser Pro  Lys Lys Lys 
    1550                 1555                 1560             


Arg Lys  Val 
    1565     


<210> 180
<211> 98
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 180
guuuuagagc ugugcuguuu aaacaacaca gcaaguuaaa auaaggcuuu guccguacuc       60

aagcuugcaa aagcgugcac cgauucggug cuuuuuuu                               98


<210> 181
<211> 107
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 181
guuugagagu agugugaaaa cauuacgagu ucaaauacaa auuaauuuac aaugccuucg       60

ggcugcccga cguagggcac cuacucucaa uucuucggaa uugagtt                    107


<210> 182
<211> 128
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 182
gucuuggaug agugugaaaa cacucauagu caagaucaaa cgagugguuu uccacgaguu       60

auuacuuuug aggucuuaua uggcccauac auaaaaagga gucggaauuu ccggcuccuu      120

uucuuuuu                                                               128


