б

<110>  ԭƼϺι˾

<120>  CLDN18.2Ŀԭϵ׼;

<130>  0065-PA-046

<160>  86

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VH DNA

<400>  1
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc aagtatggtg tacagtgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtg atatgggctg gtggaaacac aaattatgat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agcctactat      300

ggtaactccc ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  2
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VH PRT

<400>  2

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asp Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Tyr Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  3
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F314C3 HCDR1

<400>  3

Lys Tyr Gly Val Gln 
1               5   


<210>  4
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 HCDR2

<400>  4

Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asp Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  5
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 HCDR3

<400>  5

Ala Tyr Tyr Gly Asn Ser Leu Asp Tyr 
1               5                   


<210>  6
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VL DNA

<400>  6
gacattgtga tgacacagac tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctaca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      240

atcagcagta tgcaggctgc agacctggca gtttattact gtctgaataa ttattttttt      300

ccattcacgt tcggctcggg gacaaagttg gaaatgaagc gg                         342


<210>  7
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VL PRT

<400>  7

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Tyr Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Met Gln Ala Ala Asp Leu Ala Val Tyr Tyr Cys Leu Asn 
                85                  90                  95      


Asn Tyr Phe Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Met 
            100                 105                 110         


Lys Arg 
        


<210>  8
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7IMAB362 LCDR1

<400>  8

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  9
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7IMAB362 LCDR2

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 LCDR3

<400>  10

Leu Asn Asn Tyr Phe Phe Pro Phe Thr 
1               5                   


<210>  11
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 VH DNA

<400>  11
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc aagtatggtg tacagtgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtg atatgggctg gtggaaacac aaattataat      180

tcggctctca tgtccagact gagcatcagg aaagaccact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agcctataat      300

ggtaactccc ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  12
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 VH PRT

<400>  12

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Asn Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  13
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 HCDR2

<400>  13

Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  14
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 HCDR3

<400>  14

Ala Tyr Asn Gly Asn Ser Leu Asp Tyr 
1               5                   


<210>  15
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 VL DNA

<400>  15
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc      240

atcagcagta tgcaggctgc agacctggca gtttattact gtctgaataa ttatattttt      300

ccattcacgt tcggctcggg gacaaagttg gaaataaagc gg                         342


<210>  16
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 VL PRT

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Met Gln Ala Ala Asp Leu Ala Val Tyr Tyr Cys Leu Asn 
                85                  90                  95      


Asn Tyr Ile Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  17
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 LCDR3

<400>  17

Leu Asn Asn Tyr Ile Phe Pro Phe Thr 
1               5                   


<210>  18
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 VH DNA

<400>  18
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc aactttggtg taaactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatgggctg gtggaagtac aaattataat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgcaca gtctgcaaac tgctgacaca gccatgtact actgtgccag agcctacttt      300

ggtaactccc ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  19
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 VH PRT

<400>  19

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Thr Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Phe Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  20
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 HCDR1

<400>  20

Asn Phe Gly Val Asn 
1               5   


<210>  21
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 HCDR2

<400>  21

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  22
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 HCDR3

<400>  22

Ala Tyr Phe Gly Asn Ser Leu Asp Tyr 
1               5                   


<210>  23
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 VL DNA

<400>  23
gacattgtga tgacccagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcaca       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaacttttga tctactgggc atccactagg      180

ggatctgggg tccctaatcg cttcatagcc agtggatctg gaacagattt cactctcacc      240

atcagcaatg tgcaggctac agacctggca gtttattact gtctgaataa ttatttttat      300

ccattcacgt tcggctcggg gacaaagttg gatataaaac gg                         342


<210>  24
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 VL PRT

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Asn Arg Phe Ile Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Gln Ala Thr Asp Leu Ala Val Tyr Tyr Cys Leu Asn 
                85                  90                  95      


Asn Tyr Phe Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Asp Ile 
            100                 105                 110         


Lys Arg 
        


<210>  25
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 LCDR3

<400>  25

Leu Asn Asn Tyr Phe Tyr Pro Phe Thr 
1               5                   


<210>  26
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 VH DNA

<400>  26
gaggtgcagc tgcaggagtc tggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc aagtatggtg tacagtgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtg atatgggctg gtggaaacac aaattatgat      180

tcggctctca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag agcctactat      300

ggtaactccc ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  27
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 VH PRT

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asp Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Tyr Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  28
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 VL DNA

<400>  28
gacattgtga tgacacagtc tccatcttcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacaatggaa atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cgctcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tctttattat      300

ccattcacgt tcggctcggg gacaaagttg gacataaaac gg                         342


<210>  29
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 VL PRT

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Asn 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Leu Tyr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Asp Ile 
            100                 105                 110         


Lys Arg 
        


<210>  30
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 LCDR1

<400>  30

Lys Ser Ser Gln Ser Leu Leu Asn Asn Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 LCDR2

<400>  31

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 LCDR3

<400>  32

Gln Asn Asp Leu Tyr Tyr Pro Phe Thr 
1               5                   


<210>  33
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR1

<400>  33

Ser Tyr Trp Ile Asn 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR2

<400>  34

Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  35
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR3

<400>  35

Ser Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 LCDR3

<400>  36

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  37
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7 H-FR1

<400>  37

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  38
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F314C31C7 H-FR2

<400>  38

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  39
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 H-FR3

<400>  39

Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  40
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C714C3 H-FR4

<400>  40

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  41
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 L-FR1

<400>  41

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Tyr 
            20              


<210>  42
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C714C3 L-FR2

<400>  42

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  43
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F3 L-FR3

<400>  43

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Met Gln Ala Ala Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  44
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 L-FR4

<400>  44

Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg 
1               5                   10      


<210>  45
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 H-FR3

<400>  45

Arg Leu Ser Ile Arg Lys Asp His Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  46
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F31C7 L-FR1

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  47
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 L-FR4

<400>  47

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  48
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 H-FR3

<400>  48

Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met His Ser Leu Gln Thr Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  49
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C7 L-FR3

<400>  49

Gly Val Pro Asn Arg Phe Ile Ala Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Val Gln Ala Thr Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  50
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  1C714C3 L-FR4

<400>  50

Phe Gly Ser Gly Thr Lys Leu Asp Ile Lys Arg 
1               5                   10      


<210>  51
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 H-FR1

<400>  51

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  52
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 L-FR1

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  53
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14C3 L-FR3

<400>  53

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 VH

<400>  54

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  55
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 VL

<400>  55

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  56
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CLDN18.1

<400>  56
atgtccacca ccacatgcca agtggtggcg ttcctcctgt ccatcctggg gctggccggc       60

tgcatcgcgg ccaccgggat ggacatgtgg agcacccagg acctgtacga caaccccgtc      120

acctccgtgt tccagtacga agggctctgg aggagctgcg tgaggcagag ttcaggcttc      180

accgaatgca ggccctattt caccatcctg ggacttccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct caggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagata      720

tacgatggag gtgcccgcac agaggacgag gtacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  57
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CLDN18.2

<400>  57
atggccgtga ctgcctgtca gggcttgggg ttcgtggttt cactgattgg gattgcgggc       60

atcattgctg ccacctgcat ggaccagtgg agcacccaag acttgtacaa caaccccgta      120

acagctgttt tcaactacca ggggctgtgg cgctcctgtg tccgagagag ctctggcttc      180

accgagtgcc ggggctactt caccctgctg gggctgccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct caggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagata      720

tacgatggag gtgcccgcac agaggacgag gtacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  58
<211>  792
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  СCLDN18.1

<400>  58
atggccacca ccacgtgcca ggtggtaggg cttctcctgt ccctcctggg tctggccggc       60

tgcatagccg ccactgggat ggacatgtgg agcactcaag acctgtatga caacccagtc      120

accgccgtgt tccagtatga agggctctgg aggagttgcg tgcaacagag ctcggggttc      180

accgagtgcc ggccatactt caccatcctg ggccttccag ccatgctgca agctgtacga      240

gccctgatga tcgtgggcat tgttctgggg gtcatcggta tcctcgtgtc catcttcgcc      300

ctgaagtgca ttcgcattgg tagcatggat gactctgcca aggccaagat gactctgact      360

tctgggatct tgttcatcat ctccggcatc tgtgcaatca ttggtgtgtc tgtgtttgcc      420

aacatgctgg tgaccaactt ctggatgtcc acagctaaca tgtacagcgg catgggcggc      480

atgggtggca tggtgcagac cgttcagacc aggtacacct ttggtgcagc tctgttcgtg      540

ggctgggttg ctggaggcct caccctgatt gggggagtga tgatgtgcat cgcctgccgt      600

ggcctgacac cagatgacag caacttcaaa gctgtgtctt accatgcctc tggccaaaat      660

gttgcctaca ggcctggagg ctttaaggcc agcactggct ttgggtccaa caccagaaac      720

aagaagatct acgatggggg tgcccgcaca gaagacgatg aacagtctca tcctaccaag      780

tatgactatg tg                                                          792


<210>  59
<211>  792
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  СCLDN18.2

<400>  59
atgtcggtga ccgcctgcca gggcttgggg tttgtggtgt cactgatcgg gtttgcgggc       60

atcattgcag ccacttgtat ggaccagtgg agcacccagg atttatacaa caacccggtg      120

accgctgtat tcaactacca agggctatgg cgttcatgcg tccgagagag ctctggcttc      180

accgagtgcc gaggctactt caccctgttg gggttgccag ccatgctgca agctgtacga      240

gccctgatga tcgtgggcat tgttctgggg gtcatcggta tcctcgtgtc catcttcgcc      300

ctgaagtgca ttcgcattgg tagcatggat gactctgcca aggccaagat gactctgact      360

tctgggatct tgttcatcat ctccggcatc tgtgcaatca ttggtgtgtc tgtgtttgcc      420

aacatgctgg tgaccaactt ctggatgtcc acagctaaca tgtacagcgg catgggcggc      480

atgggtggca tggtgcagac cgttcagacc aggtacacct ttggtgcagc tctgttcgtg      540

ggctgggttg ctggaggcct caccctgatt gggggagtga tgatgtgcat cgcctgccgt      600

ggcctgacac cagatgacag caacttcaaa gctgtgtctt accatgcctc tggccaaaat      660

gttgcctaca ggcctggagg ctttaaggcc agcactggct ttgggtccaa caccagaaac      720

aagaagatct acgatggggg tgcccgcaca gaagacgatg aacagtctca tcctaccaag      780

tatgactatg tg                                                          792


<210>  60
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ʳз CLDN18.1

<400>  60
atgtccacca ccacatgcca agtggtggcg ttcctcctgt ccatcctggg gctggcgggc       60

tgcatcgcgg ccaccgggat ggacatgtgg agcacccagg acctgtacga caaccccgtc      120

acctctgtgt tccagtacga agggctgtgg aggagctgcg tgaggcagag ctcggggttc      180

accgagtgca ggccctattt caccatcctg ggccttccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcag ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct cgggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagaca      720

tatgatgggg gtgcccacac agaggacgag ttacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  61
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ʳзCLDN18.2

<400>  61
atggccgtga ctgcctgtca gggcttgggg ttcgtggttt cactgattgg gattgcgggc       60

atcattgctg ccacctgcat ggaccagtgg agcacccaag acttgtacaa caaccccgtg      120

acagctgtat tcaactacca ggggctgtgg cgctcctgtg tccgagagag ctctggcttc      180

accgagtgca ggggctactt caccctgctg gggctgccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct cgggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagaca      720

tatgatgggg gtgcccacac agaggacgag ttacaatctt atccgtccaa gcacgactat      780

gtg                                                                    783


<210>  62
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F314C3 HCDR1; 1C7 HCDR1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AsnGln

<400>  62

Xaa Xaa Gly Val Xaa 
1               5   


<210>  63
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 HCDR2; 5F3 HCDR2; 1C7 HCDR2

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AspAsn

<400>  63

Val Ile Trp Ala Gly Gly Xaa Thr Asn Tyr Xaa Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  64
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 HCDR3; 5F3 HCDR3; 1C7 HCDR3

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = PheAsnTyr

<400>  64

Ala Tyr Xaa Gly Asn Ser Leu Asp Tyr 
1               5                   


<210>  65
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7IMAB362 LCDR1; 14C3 LCDR1

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AlaThr

<400>  65

Lys Ser Ser Gln Ser Leu Leu Asn Xaa Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  66
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7IMAB362 LCDR2; 14C3 LCDR2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GlyTrp

<400>  66

Xaa Ala Ser Thr Arg Glu Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 LCDR3; 5F3 LCDR3; 1C7 LCDR3; 14C3 LCDR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = LeuTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = PheIleTyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = PheTyr

<400>  67

Xaa Asn Xaa Xaa Xaa Xaa Pro Phe Thr 
1               5                   


<210>  68
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F31C7 H-FR1; 14C3 H-FR1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysGln

<400>  68

Xaa Val Gln Leu Xaa Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  69
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C1014C3 H-FR3; 5F3 H-FR3; 1C7 H-FR3

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaAsp

<400>  69

Arg Leu Ser Ile Xaa Lys Asp Xaa Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met Xaa Ser Leu Gln Thr Xaa Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  70
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 L-FR1; 5F31C7 L-FR1; 14C3 L-FR1

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = CysTyr

<400>  70

Asp Ile Val Met Thr Gln Xaa Pro Ser Ser Leu Xaa Val Xaa Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Xaa 
            20              


<210>  71
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C105F3 L-FR3; 1C7 L-FR3; 14C3 L-FR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = MetVal

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = AlaGluThr

<400>  71

Gly Val Pro Xaa Arg Phe Xaa Xaa Ser Gly Ser Gly Thr Asp Phe Xaa 
1               5                   10                  15      


Leu Thr Ile Ser Xaa Xaa Gln Ala Xaa Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 L-FR4; 5F3 L-FR4; 1C714C3 L-FR4

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleMet

<400>  72

Phe Gly Ser Gly Thr Lys Leu Xaa Xaa Lys Arg 
1               5                   10      


<210>  73
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VH PRT; 5F3 VH PRT; 1C7 VH PRT; 14C3 VH PRT

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = AsnGln

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaAsp

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = PheAsnTyr

<400>  73

Xaa Val Gln Leu Xaa Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Xaa Xaa 
            20                  25                  30          


Gly Val Xaa Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Xaa Thr Asn Tyr Xaa Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Xaa Lys Asp Xaa Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Xaa Ser Leu Gln Thr Xaa Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Xaa Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  74
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5C10 VL PRT; 5F3 VL PRT; 1C7 VL PRT; 14C3 VL PRT

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = CysTyr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = GlyTrp

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = GluGly

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = MetVal

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = AlaGluThr

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa = LeuGln

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa = LeuTyr

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa = PheIleTyr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = IleMet

<400>  74

Asp Ile Val Met Thr Gln Xaa Pro Ser Ser Leu Xaa Val Xaa Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Xaa Lys Ser Ser Gln Ser Leu Leu Asn Xaa 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Xaa Ser Gly Val 
    50                  55                  60                  


Pro Xaa Arg Phe Xaa Xaa Ser Gly Ser Gly Thr Asp Phe Xaa Leu Thr 
65                  70                  75                  80  


Ile Ser Xaa Xaa Gln Ala Xaa Asp Leu Ala Val Tyr Tyr Cys Xaa Asn 
                85                  90                  95      


Xaa Xaa Xaa Xaa Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Xaa Xaa 
            100                 105                 110         


Lys Arg 
        


<210>  75
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 

<400>  75

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  76
<211>  220
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 

<400>  76

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  77
<211>  45
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8

<400>  77

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  78
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8Ĥ

<400>  78

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  79
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼

<400>  79

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  80
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3 źŴ

<400>  80

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  81
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T2Aи

<400>  81

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  82
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8ź

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  83
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  linker

<400>  83

Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  84
<211>  416
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ori

<400>  84

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys 
            20                  25                  30          


Val Leu Leu Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
        35                  40                  45              


Pro Pro Thr Cys Ser Pro Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile 
    50                  55                  60                  


Asp Cys Ile Pro Val Ala Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu 
65                  70                  75                  80  


Asp His Ser Asp Glu Leu Asn Cys Pro Val Cys Ser Glu Ser Gln Phe 
                85                  90                  95      


Gln Cys Ala Ser Gly Gln Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly 
            100                 105                 110         


Asp Ala Asn Cys Gln Asp Lys Ser Asp Glu Lys Asn Cys Glu Val Leu 
        115                 120                 125             


Cys Leu Ile Asp Gln Phe Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys 
    130                 135                 140                 


His Lys Lys Cys Asp His Asn Val Asp Cys Ser Asp Lys Ser Asp Glu 
145                 150                 155                 160 


Leu Asp Cys Tyr Pro Thr Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr 
                165                 170                 175     


Val Gly Ser Val Ile Gly Val Ile Val Thr Ile Phe Val Ser Gly Thr 
            180                 185                 190         


Val Tyr Phe Ile Cys Gln Arg Met Leu Cys Pro Arg Met Lys Gly Asp 
        195                 200                 205             


Gly Glu Thr Met Thr Asn Asp Tyr Val Val His Gly Pro Ala Ser Val 
    210                 215                 220                 


Pro Leu Gly Tyr Val Pro His Pro Ser Ser Leu Ser Gly Ser Leu Pro 
225                 230                 235                 240 


Gly Met Ser Arg Gly Lys Ser Met Ile Ser Ser Leu Ser Ile Met Gly 
                245                 250                 255     


Gly Ser Ser Gly Pro Pro Tyr Asp Arg Ala His Val Thr Gly Ala Ser 
            260                 265                 270         


Ser Ser Ser Ser Ser Ser Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu 
        275                 280                 285             


Asn Pro Pro Pro Ser Pro Ala Thr Glu Arg Ser His Tyr Thr Met Glu 
    290                 295                 300                 


Phe Gly Tyr Ser Ser Asn Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr 
305                 310                 315                 320 


Arg Pro Tyr Ser Tyr Arg His Phe Ala Pro Pro Thr Thr Pro Cys Ser 
                325                 330                 335     


Thr Asp Val Cys Asp Ser Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser 
            340                 345                 350         


Val Ala Thr Ala Lys Gly Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu 
        355                 360                 365             


Pro Val Pro Pro Pro Pro Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu 
    370                 375                 380                 


Glu Asn Tyr Glu Ser Cys Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr 
385                 390                 395                 400 


Ser His His Leu Tyr Pro Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser 
                405                 410                 415     


<210>  85
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5F3 scFv

<400>  85

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Met Gln Ala Ala Asp Leu Ala Val Tyr Tyr Cys Leu Asn 
                85                  90                  95      


Asn Tyr Ile Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
    130                 135                 140                 


Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys 
145                 150                 155                 160 


Tyr Gly Val Gln Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu 
            180                 185                 190         


Met Ser Arg Leu Ser Ile Arg Lys Asp His Ser Lys Ser Gln Val Phe 
        195                 200                 205             


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ala Tyr Asn Gly Asn Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Leu Thr Val Ser Ser 
                245     


<210>  86
<211>  247
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  standard scFv

<400>  86

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ile Lys Pro Ser 
    130                 135                 140                 


Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser 
145                 150                 155                 160 


Gly Tyr Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Tyr Ile His Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ala 
            180                 185                 190         


Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Ile Tyr Asn Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Val Thr Val Ser Ser 
                245         
