                         SEQUENCE LISTING

<110>  Emergence Therapeutics AG
 
<120>  Anti-nectin-4-Antibodies

<130>  72511P WO

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_15A7.5 IMGT

<400>  1

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_15A7.5 IMGT

<400>  2

Ile Ser Asn Leu Ala Tyr Gly Ile 
1               5               


<210>  3
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_15A7.5 IMGT

<400>  3

Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  4
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_15A7.5 IMGT

<400>  4

Gln Asn Val Asp Thr His 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_15A7.5 IMGT

<400>  5

Ser Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_15A7.5 IMGT

<400>  6

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_15A7.5 Kabat

<400>  7

Asn Tyr Gly Met Ala 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_15A7.5 Kabat

<400>  8

Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_15A7.5 Kabat

<400>  9

Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  10
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_15A7.5 Kabat

<400>  10

Lys Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_15A7.5 Kabat

<400>  11

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_15A7.5 Kabat

<400>  12

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  13
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH_15A7.5

<400>  13

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Arg Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  14
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VK_15A7.5

<400>  14

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Gln Glu Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H0_15A7.5  IMGT

<400>  15

Gly Phe Thr Phe Ser Asn Tyr Gly Met 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H0_15A7.5  IMGT

<400>  16

Ile Ser Asn Leu Ala Tyr Gly Ile 
1               5               


<210>  17
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H0_15A7.5  IMGT

<400>  17

Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  18
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L0_15A7.5 IMGT

<400>  18

Gln Asn Val Asp Thr His 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L0_15A7.5 IMGT

<400>  19

Ser Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L0_15A7.5 IMGT

<400>  20

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H0_15A7.5  Kabat

<400>  21

Asn Tyr Gly Met Asn 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H0_15A7.5  Kabat

<400>  22

Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H0_15A7.5  Kabat

<400>  23

Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L0_15A7.5 Kabat

<400>  24

Arg Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L0_15A7.5 Kabat

<400>  25

Ser Ala Ser Tyr Leu Gln Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L0_15A7.5 Kabat

<400>  26

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  27
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  H0_15A7.5

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  L0_15A7.5

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H1_15A7.5 IMGT

<400>  29

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H1_15A7.5 IMGT

<400>  30

Ile Ser Asn Leu Ala Tyr Gly Ile 
1               5               


<210>  31
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H1_15A7.5 IMGT

<400>  31

Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  32
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L1_15A7.5 IMGT

<400>  32

Gln Asn Val Asp Thr His 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L1_15A7.5 IMGT

<400>  33

Ser Ala Ser 
1           


<210>  34
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L1_15A7.5 IMGT

<400>  34

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  35
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H1_15A7.5 Kabat

<400>  35

Asn Tyr Gly Met Ala 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H1_15A7.5 Kabat

<400>  36

Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H1_15A7.5 Kabat

<400>  37

Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  38
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L1_15A7.5 Kabat

<400>  38

Lys Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L1_15A7.5 Kabat

<400>  39

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L1_15A7.5 Kabat

<400>  40

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  41
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  H1_15A7.5

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  L1_15A7.5

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Cys Lys Ala Ser Gln Asn Val Asp Thr 
            20                  25                  30          


His Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  43
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H2_15A7.5 IMGT

<400>  43

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H2_15A7.5 IMGT

<400>  44

Ile Ser Asn Leu Ala Tyr Gly Ile 
1               5               


<210>  45
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H2_15A7.5 IMGT

<400>  45

Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  46
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L2_15A7.5 IMGT

<400>  46

Gln Asn Val Asp Thr His 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L2_15A7.5 IMGT

<400>  47

Ser Ala Ser 
1           


<210>  48
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L2_15A7.5 IMGT

<400>  48

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  49
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H2_15A7.5 Kabat

<400>  49

Asn Tyr Gly Met Ala 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H2_15A7.5 Kabat

<400>  50

Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H2_15A7.5 Kabat

<400>  51

Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  52
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L2_15A7.5 Kabat

<400>  52

Lys Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L2_15A7.5 Kabat

<400>  53

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L2_15A7.5 Kabat

<400>  54

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  55
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  H2_15A7.5

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  L2_15A7.5

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  57
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H3_15A7.5 IMGT

<400>  57

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H3_15A7.5 IMGT

<400>  58

Ile Ser Asn Leu Ala Tyr Gly Ile 
1               5               


<210>  59
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H3_15A7.5 IMGT

<400>  59

Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10          


<210>  60
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L3_15A7.5 IMGT

<400>  60

Gln Asn Val Asp Thr His 
1               5       


<210>  61
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L3_15A7.5 IMGT

<400>  61

Ser Ala Ser 
1           


<210>  62
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L3_15A7.5 IMGT

<400>  62

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  63
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 H3_15A7.5 Kabat

<400>  63

Asn Tyr Gly Met Ala 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 H3_15A7.5 Kabat

<400>  64

Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 H3_15A7.5 Kabat

<400>  65

Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  66
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 L3_15A7.5 Kabat

<400>  66

Lys Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 L3_15A7.5 Kabat

<400>  67

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 L3_15A7.5 Kabat

<400>  68

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  69
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  H3_15A7.5

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Leu Ala Tyr Gly Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Ala Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  L3_15A7.5

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Ala Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  71
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_5A12.2

<400>  71

Gly Phe Thr Phe Asn Ser Met Tyr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_5A12.2

<400>  72

Ile Tyr Ala Gly Thr Gly Gly Thr 
1               5               


<210>  73
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_5A12.2

<400>  73

Ala Ile Arg Ser Gly Phe Val Pro Met Asp Tyr Trp Gly 
1               5                   10              


<210>  74
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH_5A12.2

<400>  74

Gln Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Asn Ser Met 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Phe Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Val Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Arg Ser Gly Phe Val Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  75
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_5A12.2

<400>  75

Gln Ser Val Ser Asn Asp 
1               5       


<210>  76
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_5A12.2

<400>  76

Tyr Ala Ser 
1           


<210>  77
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_5A12.2

<400>  77

Gln Gln Asp Tyr Ser Ser 
1               5       


<210>  78
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VK_5A12.2

<400>  78

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  79
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_9A2.7

<400>  79

Gly Tyr Asn Phe Thr Thr Phe Trp 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_9A2.7

<400>  80

Ile Tyr Pro Ser Asp Ser Tyr Ala 
1               5               


<210>  81
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_9A2.7

<400>  81

Thr Arg Pro Ser Tyr Phe Gly Arg Asn Ser Phe Ala Tyr 
1               5                   10              


<210>  82
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH_9A2.7

<400>  82

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Thr Phe 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Pro Ser Tyr Phe Gly Arg Asn Ser Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  83
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_9A2.7

<400>  83

Gln Ser Leu Leu Tyr Ser Val Asn His Lys Asn Tyr 
1               5                   10          


<210>  84
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_9A2.7

<400>  84

Trp Ala Ser 
1           


<210>  85
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_9A2.7

<400>  85

His Gln Tyr Tyr Thr Tyr Pro Leu Thr 
1               5                   


<210>  86
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  VK_9A2.7

<400>  86

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Val Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  87
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_3A1.4

<400>  87

Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_3A1.4

<400>  88

Ile Ser Asn Ser Gly Ile Thr 
1               5           


<210>  89
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_3A1.4

<400>  89

Thr Arg Phe Gly Ser Thr Met Ile Leu Tyr Tyr Thr Met Asp Tyr 
1               5                   10                  15  


<210>  90
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH_3A1.4

<400>  90

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Asn Ser Gly Ile Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Phe Gly Ser Thr Met Ile Leu Tyr Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  91
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_3A1.4

<400>  91

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  92
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_3A1.4

<400>  92

Tyr Ala Ser 
1           


<210>  93
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_3A1.4

<400>  93

Gln Asn Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  94
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VK_3A1.4

<400>  94

Asp Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gln Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Lys Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asn Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  95
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH_8F06

<400>  95

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH_8F06

<400>  96

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  97
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH_8F06

<400>  97

Val Thr Leu Phe Ala Tyr 
1               5       


<210>  98
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH_8F06

<400>  98

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  99
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VK_8F06

<400>  99

Ser Ser Ile Ser Tyr 
1               5   


<210>  100
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VK_8F06

<400>  100

Asp Thr Ser 
1           


<210>  101
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VK_8F06

<400>  101

His Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  102
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  VK_8F06

<400>  102

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  103
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  L3_15A7.5_mod

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Ala Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105       
