                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  Syringes containing pharmaceutical compositions comprising RNA

<130>  CU01P336WO1

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  3
<211>  3822
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike CDS

<400>  3
auguucgugu uccugguccu ccugccccug gugagcuccc agugcgugaa ccucaccacc       60

cgcacgcagc ugccgcccgc cuacaccaac agcuucaccc ggggcgucua cuaccccgac      120

aagguguucc gcuccagcgu gcugcacucc acccaggacc ucuuccugcc cuucuucagc      180

aacgucacgu gguuccacgc cauccacgug uccgggacca acggcaccaa gcgguucgac      240

aacccggugc ugcccuucaa cgacgggguc uacuucgcga gcaccgagaa guccaacauc      300

auccgcggcu ggaucuucgg gacgacccuc gacagcaaga cccagucccu gcugaucgug      360

aacaacgcca ccaacguggu caucaaggug ugcgaguucc aguucugcaa cgaccccuuc      420

cucggcgugu acuaccacaa gaacaacaag agcuggaugg aguccgaguu ccgggucuac      480

agcuccgcca acaacugcac guucgaguac gugagccagc ccuuccugau ggaccuggag      540

ggcaagcagg ggaacuucaa gaaccuccgc gaguucgugu ucaagaacau cgacggcuac      600

uucaagaucu acuccaagca caccccgauc aaccuggucc gggaccugcc ccagggguuc      660

agcgcccucg agccccuggu ggaccugccc aucggcauca acaucacccg cuuccagacc      720

cuccuggccc ugcaccgguc cuaccucacg ccgggggaca gcagcuccgg cuggaccgcg      780

ggcgccgccg ccuacuacgu gggguaccug cagccccgca ccuuccugcu caaguacaac      840

gagaacggca ccaucacgga cgcggucgac ugcgcccugg acccccugag cgagaccaag      900

ugcacccuca aguccuucac cguggagaag gggaucuacc agacgagcaa cuuccgggug      960

cagcccaccg aguccaucgu ccgcuucccg aacaucacca accugugccc cuucggcgag     1020

guguucaacg ccacccgguu cgccagcguc uacgccugga accgcaagcg gaucuccaac     1080

ugcguggcgg acuacagcgu gcuguacaac uccgccagcu ucuccacguu caagugcuac     1140

ggcgucagcc ccaccaagcu caacgaccug ugcuucacca acguguacgc cgacuccuuc     1200

gugauccgcg gggacgaggu ccggcagauc gcccccggcc agaccgggaa gaucgccgac     1260

uacaacuaca agcugccgga cgacuucacg ggcugcguga ucgcguggaa cagcaacaac     1320

cucgacucca aggucggggg caacuacaac uaccuguacc gccuguuccg caagagcaac     1380

cucaagcccu ucgagcggga caucuccacc gagaucuacc aggccggcag cacccccugc     1440

aacggggugg agggcuucaa cugcuacuuc ccccugcagu ccuacggguu ccagccgacc     1500

aacggcgugg gguaccagcc cuaccgggug gucgugcuga gcuucgagcu ccugcacgcc     1560

cccgccacgg ugugcggccc caagaagucc accaaccugg ucaagaacaa gugcgugaac     1620

uucaacuuca acggccucac cgggaccggc gugcugaccg agagcaacaa gaaguuccug     1680

ccguuccagc aguucgggcg cgacaucgcc gacacgaccg acgcgguccg cgacccccag     1740

acccuggaga uccucgacau cacccccugc agcuucggcg ggguguccgu gaucacgccg     1800

ggcaccaaca ccagcaacca ggucgccgug cuguaccagg acgugaacug caccgagguc     1860

cccguggcca uccacgccga ccagcugacg cccaccuggc ggguguacuc caccggcagc     1920

aacgucuucc agacccgcgc cgggugccuc aucggcgcgg agcacgugaa caacuccuac     1980

gagugcgaca uccccaucgg ggccggcauc ugcgccagcu accagacgca gaccaacucc     2040

ccgcggcgcg cccggagcgu ggcgucccag agcaucaucg ccuacaccau gucccugggc     2100

gccgagaaca gcgucgccua cuccaacaac agcaucgcca uccccaccaa cuucacgauc     2160

uccgugacca ccgagauccu gcccgugagc augaccaaga cgagcgucga cugcaccaug     2220

uacaucugcg gggacuccac cgagugcagc aaccuccugc ugcaguacgg cuccuucugc     2280

acccagcuca accgcgcgcu gacggggauc gccguggagc aggacaagaa cacccaggag     2340

guguucgccc aggucaagca gaucuacaag acgcccccga ucaaggacuu cggcggguuc     2400

aacuucagcc agauccugcc cgaccccucc aagcccagca agcgguccuu caucgaggac     2460

cuccuguuca acaaggugac ccuggccgac gccggcuuca ucaagcagua cggcgacugc     2520

cucggggaca ucgcggcccg cgaccugauc ugcgcccaga aguucaacgg ccugaccgug     2580

cucccgcccc ugcugaccga cgagaugauc gcccaguaca ccagcgcccu ccuggcgggg     2640

accaucacgu ccggcuggac cuucggggcc ggcgccgccc ugcagauccc cuucgcgaug     2700

cagauggccu accgguucaa cggcaucggg gucacccaga acgugcucua cgagaaccag     2760

aagcugaucg ccaaccaguu caacagcgcc aucggcaaga uccaggacuc ccugagcucc     2820

accgccagcg cgcucgggaa gcugcaggac guggucaacc agaacgccca ggcccugaac     2880

acgcucguga agcagcuguc cagcaacuuc ggcgccaucu ccagcgugcu gaacgacauc     2940

cucucccgcc uggacccgcc cgaggccgag gugcagaucg accggcugau caccgggcgc     3000

cuccagagcc ugcagaccua cgugacccag cagcugaucc gggcggccga gauccgcgcc     3060

agcgccaacc ucgccgcgac caagaugucc gagugcgucc ugggccagag caagcgggug     3120

gacuucugcg gcaaggggua ccaccugaug uccuuccccc agagcgcccc gcacggcgug     3180

gucuuccucc acgugacgua cguccccgcc caggagaaga acuucaccac cgcccccgcg     3240

aucugccacg acgggaaggc ccacuucccc cgcgagggcg uguucguguc caacgggacc     3300

cacugguucg ucacgcagcg gaacuucuac gagccgcaga ucaucaccac cgacaacacc     3360

uucgugagcg gcaacugcga cguggucauc ggcaucguga acaacacggu guacgacccc     3420

cugcagcccg agcuggacuc cuucaaggag gagcucgaca aguacuucaa gaaccacacc     3480

agccccgacg ucgaccuggg ggacaucucc ggcaucaacg ccagcguggu gaacauccag     3540

aaggagaucg accgccugaa cgaggucgcc aagaaccuca acgagucccu gaucgaccug     3600

caggagcucg ggaaguacga gcaguacauc aaguggccgu gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgcgau cgugauggug accaucaugc ucugcugcau gaccagcugc     3720

ugcuccugcc ugaaggggug cugcagcugc ggcuccugcu gcaaguucga cgaggacgac     3780

agcgagcccg uccugaaggg ggugaagcuc cacuacacgu ga                        3822


<210>  4
<211>  3813
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike CDS

<400>  4
auguucgugu uccugguccu ccugccccug gugagcuccc agugcgugaa cuucaccacc       60

cgcacgcagc ugccgcccgc cuacaccaac agcuucaccc ggggcgucua cuaccccgac      120

aagguguucc gcuccagcgu gcugcacucc acccaggacc ucuuccugcc cuucuucagc      180

aacgucacgu gguuccacgc cauccacgug uccgggacca acggcaccaa gcgguucgcc      240

aacccggugc ugcccuucaa cgacgggguc uacuucgcga gcaccgagaa guccaacauc      300

auccgcggcu ggaucuucgg gacgacccuc gacagcaaga cccagucccu gcugaucgug      360

aacaacgcca ccaacguggu caucaaggug ugcgaguucc aguucugcaa cgaccccuuc      420

cucggcgugu acuaccacaa gaacaacaag agcuggaugg aguccgaguu ccgggucuac      480

agcuccgcca acaacugcac guucgaguac gugagccagc ccuuccugau ggaccuggag      540

ggcaagcagg ggaacuucaa gaaccuccgc gaguucgugu ucaagaacau cgacggcuac      600

uucaagaucu acuccaagca caccccgauc aaccuggucc ggggccugcc ccagggguuc      660

agcgcccucg agccccuggu ggaccugccc aucggcauca acaucacccg cuuccagacc      720

cuccacaucu ccuaccucac gccgggggac agcagcuccg gcuggaccgc gggcgccgcc      780

gccuacuacg ugggguaccu gcagccccgc accuuccugc ucaaguacaa cgagaacggc      840

accaucacgg acgcggucga cugcgcccug gacccccuga gcgagaccaa gugcacccuc      900

aaguccuuca ccguggagaa ggggaucuac cagacgagca acuuccgggu gcagcccacc      960

gaguccaucg uccgcuuccc gaacaucacc aaccugugcc ccuucggcga gguguucaac     1020

gccacccggu ucgccagcgu cuacgccugg aaccgcaagc ggaucuccaa cugcguggcg     1080

gacuacagcg ugcuguacaa cuccgccagc uucuccacgu ucaagugcua cggcgucagc     1140

cccaccaagc ucaacgaccu gugcuucacc aacguguacg ccgacuccuu cgugauccgc     1200

ggggacgagg uccggcagau cgcccccggc cagaccggga acaucgccga cuacaacuac     1260

aagcugccgg acgacuucac gggcugcgug aucgcgugga acagcaacaa ccucgacucc     1320

aaggucgggg gcaacuacaa cuaccuguac cgccuguucc gcaagagcaa ccucaagccc     1380

uucgagcggg acaucuccac cgagaucuac caggccggca gcacccccug caacggggug     1440

aagggcuuca acugcuacuu cccccugcag uccuacgggu uccagccgac cuacggcgug     1500

ggguaccagc ccuaccgggu ggucgugcug agcuucgagc uccugcacgc ccccgccacg     1560

gugugcggcc ccaagaaguc caccaaccug gucaagaaca agugcgugaa cuucaacuuc     1620

aacggccuca ccgggaccgg cgugcugacc gagagcaaca agaaguuccu gccguuccag     1680

caguucgggc gcgacaucgc cgacacgacc gacgcggucc gcgaccccca gacccuggag     1740

auccucgaca ucacccccug cagcuucggc gggguguccg ugaucacgcc gggcaccaac     1800

accagcaacc aggucgccgu gcuguaccag ggcgugaacu gcaccgaggu ccccguggcc     1860

auccacgccg accagcugac gcccaccugg cggguguacu ccaccggcag caacgucuuc     1920

cagacccgcg ccgggugccu caucggcgcg gagcacguga acaacuccua cgagugcgac     1980

auccccaucg gggccggcau cugcgccagc uaccagacgc agaccaacuc cccgcggcgc     2040

gcccggagcg uggcguccca gagcaucauc gccuacacca ugucccuggg cguggagaac     2100

agcgucgccu acuccaacaa cagcaucgcc auccccacca acuucacgau cuccgugacc     2160

accgagaucc ugcccgugag caugaccaag acgagcgucg acugcaccau guacaucugc     2220

ggggacucca ccgagugcag caaccuccug cugcaguacg gcuccuucug cacccagcuc     2280

aaccgcgcgc ugacggggau cgccguggag caggacaaga acacccagga gguguucgcc     2340

caggucaagc agaucuacaa gacgcccccg aucaaggacu ucggcggguu caacuucagc     2400

cagauccugc ccgaccccuc caagcccagc aagcgguccu ucaucgagga ccuccuguuc     2460

aacaagguga cccuggccga cgccggcuuc aucaagcagu acggcgacug ccucggggac     2520

aucgcggccc gcgaccugau cugcgcccag aaguucaacg gccugaccgu gcucccgccc     2580

cugcugaccg acgagaugau cgcccaguac accagcgccc uccuggcggg gaccaucacg     2640

uccggcugga ccuucggggc cggcgccgcc cugcagaucc ccuucgcgau gcagauggcc     2700

uaccgguuca acggcaucgg ggucacccag aacgugcucu acgagaacca gaagcugauc     2760

gccaaccagu ucaacagcgc caucggcaag auccaggacu cccugagcuc caccgccagc     2820

gcgcucggga agcugcagga cguggucaac cagaacgccc aggcccugaa cacgcucgug     2880

aagcagcugu ccagcaacuu cggcgccauc uccagcgugc ugaacgacau ccucucccgc     2940

cuggacccgc ccgaggccga ggugcagauc gaccggcuga ucaccgggcg ccuccagagc     3000

cugcagaccu acgugaccca gcagcugauc cgggcggccg agauccgcgc cagcgccaac     3060

cucgccgcga ccaagauguc cgagugcguc cugggccaga gcaagcgggu ggacuucugc     3120

ggcaaggggu accaccugau guccuucccc cagagcgccc cgcacggcgu ggucuuccuc     3180

cacgugacgu acguccccgc ccaggagaag aacuucacca ccgcccccgc gaucugccac     3240

gacgggaagg cccacuuccc ccgcgagggc guguucgugu ccaacgggac ccacugguuc     3300

gucacgcagc ggaacuucua cgagccgcag aucaucacca ccgacaacac cuucgugagc     3360

ggcaacugcg acguggucau cggcaucgug aacaacacgg uguacgaccc ccugcagccc     3420

gagcuggacu ccuucaagga ggagcucgac aaguacuuca agaaccacac cagccccgac     3480

gucgaccugg gggacaucuc cggcaucaac gccagcgugg ugaacaucca gaaggagauc     3540

gaccgccuga acgaggucgc caagaaccuc aacgaguccc ugaucgaccu gcaggagcuc     3600

gggaaguacg agcaguacau caaguggccg ugguacaucu ggcugggcuu caucgccggc     3660

cugaucgcga ucgugauggu gaccaucaug cucugcugca ugaccagcug cugcuccugc     3720

cugaaggggu gcugcagcug cggcuccugc ugcaaguucg acgaggacga cagcgagccc     3780

guccugaagg gggugaagcu ccacuacacg uga                                  3813


<210>  5
<211>  4039
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R9515

<400>  5
aggagaaagc uuaccauguu cguguuccug guccuccugc cccuggugag cucccagugc       60

gugaaccuca ccacccgcac gcagcugccg cccgccuaca ccaacagcuu cacccggggc      120

gucuacuacc ccgacaaggu guuccgcucc agcgugcugc acuccaccca ggaccucuuc      180

cugcccuucu ucagcaacgu cacgugguuc cacgccaucc acguguccgg gaccaacggc      240

accaagcggu ucgacaaccc ggugcugccc uucaacgacg gggucuacuu cgcgagcacc      300

gagaagucca acaucauccg cggcuggauc uucgggacga cccucgacag caagacccag      360

ucccugcuga ucgugaacaa cgccaccaac guggucauca aggugugcga guuccaguuc      420

ugcaacgacc ccuuccucgg cguguacuac cacaagaaca acaagagcug gauggagucc      480

gaguuccggg ucuacagcuc cgccaacaac ugcacguucg aguacgugag ccagcccuuc      540

cugauggacc uggagggcaa gcaggggaac uucaagaacc uccgcgaguu cguguucaag      600

aacaucgacg gcuacuucaa gaucuacucc aagcacaccc cgaucaaccu gguccgggac      660

cugccccagg gguucagcgc ccucgagccc cugguggacc ugcccaucgg caucaacauc      720

acccgcuucc agacccuccu ggcccugcac cgguccuacc ucacgccggg ggacagcagc      780

uccggcugga ccgcgggcgc cgccgccuac uacguggggu accugcagcc ccgcaccuuc      840

cugcucaagu acaacgagaa cggcaccauc acggacgcgg ucgacugcgc ccuggacccc      900

cugagcgaga ccaagugcac ccucaagucc uucaccgugg agaaggggau cuaccagacg      960

agcaacuucc gggugcagcc caccgagucc aucguccgcu ucccgaacau caccaaccug     1020

ugccccuucg gcgagguguu caacgccacc cgguucgcca gcgucuacgc cuggaaccgc     1080

aagcggaucu ccaacugcgu ggcggacuac agcgugcugu acaacuccgc cagcuucucc     1140

acguucaagu gcuacggcgu cagccccacc aagcucaacg accugugcuu caccaacgug     1200

uacgccgacu ccuucgugau ccgcggggac gagguccggc agaucgcccc cggccagacc     1260

gggaagaucg ccgacuacaa cuacaagcug ccggacgacu ucacgggcug cgugaucgcg     1320

uggaacagca acaaccucga cuccaagguc gggggcaacu acaacuaccu guaccgccug     1380

uuccgcaaga gcaaccucaa gcccuucgag cgggacaucu ccaccgagau cuaccaggcc     1440

ggcagcaccc ccugcaacgg gguggagggc uucaacugcu acuucccccu gcaguccuac     1500

ggguuccagc cgaccaacgg cgugggguac cagcccuacc ggguggucgu gcugagcuuc     1560

gagcuccugc acgcccccgc cacggugugc ggccccaaga aguccaccaa ccuggucaag     1620

aacaagugcg ugaacuucaa cuucaacggc cucaccggga ccggcgugcu gaccgagagc     1680

aacaagaagu uccugccguu ccagcaguuc gggcgcgaca ucgccgacac gaccgacgcg     1740

guccgcgacc cccagacccu ggagauccuc gacaucaccc ccugcagcuu cggcggggug     1800

uccgugauca cgccgggcac caacaccagc aaccaggucg ccgugcugua ccaggacgug     1860

aacugcaccg agguccccgu ggccauccac gccgaccagc ugacgcccac cuggcgggug     1920

uacuccaccg gcagcaacgu cuuccagacc cgcgccgggu gccucaucgg cgcggagcac     1980

gugaacaacu ccuacgagug cgacaucccc aucggggccg gcaucugcgc cagcuaccag     2040

acgcagacca acuccccgcg gcgcgcccgg agcguggcgu cccagagcau caucgccuac     2100

accauguccc ugggcgccga gaacagcguc gccuacucca acaacagcau cgccaucccc     2160

accaacuuca cgaucuccgu gaccaccgag auccugcccg ugagcaugac caagacgagc     2220

gucgacugca ccauguacau cugcggggac uccaccgagu gcagcaaccu ccugcugcag     2280

uacggcuccu ucugcaccca gcucaaccgc gcgcugacgg ggaucgccgu ggagcaggac     2340

aagaacaccc aggagguguu cgcccagguc aagcagaucu acaagacgcc cccgaucaag     2400

gacuucggcg gguucaacuu cagccagauc cugcccgacc ccuccaagcc cagcaagcgg     2460

uccuucaucg aggaccuccu guucaacaag gugacccugg ccgacgccgg cuucaucaag     2520

caguacggcg acugccucgg ggacaucgcg gcccgcgacc ugaucugcgc ccagaaguuc     2580

aacggccuga ccgugcuccc gccccugcug accgacgaga ugaucgccca guacaccagc     2640

gcccuccugg cggggaccau cacguccggc uggaccuucg gggccggcgc cgcccugcag     2700

auccccuucg cgaugcagau ggccuaccgg uucaacggca ucggggucac ccagaacgug     2760

cucuacgaga accagaagcu gaucgccaac caguucaaca gcgccaucgg caagauccag     2820

gacucccuga gcuccaccgc cagcgcgcuc gggaagcugc aggacguggu caaccagaac     2880

gcccaggccc ugaacacgcu cgugaagcag cuguccagca acuucggcgc caucuccagc     2940

gugcugaacg acauccucuc ccgccuggac ccgcccgagg ccgaggugca gaucgaccgg     3000

cugaucaccg ggcgccucca gagccugcag accuacguga cccagcagcu gauccgggcg     3060

gccgagaucc gcgccagcgc caaccucgcc gcgaccaaga uguccgagug cguccugggc     3120

cagagcaagc ggguggacuu cugcggcaag ggguaccacc ugauguccuu cccccagagc     3180

gccccgcacg gcguggucuu ccuccacgug acguacgucc ccgcccagga gaagaacuuc     3240

accaccgccc ccgcgaucug ccacgacggg aaggcccacu ucccccgcga gggcguguuc     3300

guguccaacg ggacccacug guucgucacg cagcggaacu ucuacgagcc gcagaucauc     3360

accaccgaca acaccuucgu gagcggcaac ugcgacgugg ucaucggcau cgugaacaac     3420

acgguguacg acccccugca gcccgagcug gacuccuuca aggaggagcu cgacaaguac     3480

uucaagaacc acaccagccc cgacgucgac cugggggaca ucuccggcau caacgccagc     3540

guggugaaca uccagaagga gaucgaccgc cugaacgagg ucgccaagaa ccucaacgag     3600

ucccugaucg accugcagga gcucgggaag uacgagcagu acaucaagug gccgugguac     3660

aucuggcugg gcuucaucgc cggccugauc gcgaucguga uggugaccau caugcucugc     3720

ugcaugacca gcugcugcuc cugccugaag gggugcugca gcugcggcuc cugcugcaag     3780

uucgacgagg acgacagcga gcccguccug aaggggguga agcuccacua cacgugagga     3840

cuaguuauaa gacugacuag cccgaugggc cucccaacgg gcccuccucc ccuccuugca     3900

ccgagauuaa uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaaaaa aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu     4020

uuucagagcc accagaauu                                                  4039


<210>  6
<211>  4030
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R10379

<400>  6
aggagaaagc uuaccauguu cguguuccug guccuccugc cccuggugag cucccagugc       60

gugaacuuca ccacccgcac gcagcugccg cccgccuaca ccaacagcuu cacccggggc      120

gucuacuacc ccgacaaggu guuccgcucc agcgugcugc acuccaccca ggaccucuuc      180

cugcccuucu ucagcaacgu cacgugguuc cacgccaucc acguguccgg gaccaacggc      240

accaagcggu ucgccaaccc ggugcugccc uucaacgacg gggucuacuu cgcgagcacc      300

gagaagucca acaucauccg cggcuggauc uucgggacga cccucgacag caagacccag      360

ucccugcuga ucgugaacaa cgccaccaac guggucauca aggugugcga guuccaguuc      420

ugcaacgacc ccuuccucgg cguguacuac cacaagaaca acaagagcug gauggagucc      480

gaguuccggg ucuacagcuc cgccaacaac ugcacguucg aguacgugag ccagcccuuc      540

cugauggacc uggagggcaa gcaggggaac uucaagaacc uccgcgaguu cguguucaag      600

aacaucgacg gcuacuucaa gaucuacucc aagcacaccc cgaucaaccu gguccggggc      660

cugccccagg gguucagcgc ccucgagccc cugguggacc ugcccaucgg caucaacauc      720

acccgcuucc agacccucca caucuccuac cucacgccgg gggacagcag cuccggcugg      780

accgcgggcg ccgccgccua cuacgugggg uaccugcagc cccgcaccuu ccugcucaag      840

uacaacgaga acggcaccau cacggacgcg gucgacugcg cccuggaccc ccugagcgag      900

accaagugca cccucaaguc cuucaccgug gagaagggga ucuaccagac gagcaacuuc      960

cgggugcagc ccaccgaguc caucguccgc uucccgaaca ucaccaaccu gugccccuuc     1020

ggcgaggugu ucaacgccac ccgguucgcc agcgucuacg ccuggaaccg caagcggauc     1080

uccaacugcg uggcggacua cagcgugcug uacaacuccg ccagcuucuc cacguucaag     1140

ugcuacggcg ucagccccac caagcucaac gaccugugcu ucaccaacgu guacgccgac     1200

uccuucguga uccgcgggga cgagguccgg cagaucgccc ccggccagac cgggaacauc     1260

gccgacuaca acuacaagcu gccggacgac uucacgggcu gcgugaucgc guggaacagc     1320

aacaaccucg acuccaaggu cgggggcaac uacaacuacc uguaccgccu guuccgcaag     1380

agcaaccuca agcccuucga gcgggacauc uccaccgaga ucuaccaggc cggcagcacc     1440

cccugcaacg gggugaaggg cuucaacugc uacuuccccc ugcaguccua cggguuccag     1500

ccgaccuacg gcguggggua ccagcccuac cggguggucg ugcugagcuu cgagcuccug     1560

cacgcccccg ccacggugug cggccccaag aaguccacca accuggucaa gaacaagugc     1620

gugaacuuca acuucaacgg ccucaccggg accggcgugc ugaccgagag caacaagaag     1680

uuccugccgu uccagcaguu cgggcgcgac aucgccgaca cgaccgacgc gguccgcgac     1740

ccccagaccc uggagauccu cgacaucacc cccugcagcu ucggcggggu guccgugauc     1800

acgccgggca ccaacaccag caaccagguc gccgugcugu accagggcgu gaacugcacc     1860

gagguccccg uggccaucca cgccgaccag cugacgccca ccuggcgggu guacuccacc     1920

ggcagcaacg ucuuccagac ccgcgccggg ugccucaucg gcgcggagca cgugaacaac     1980

uccuacgagu gcgacauccc caucggggcc ggcaucugcg ccagcuacca gacgcagacc     2040

aacuccccgc ggcgcgcccg gagcguggcg ucccagagca ucaucgccua caccaugucc     2100

cugggcgugg agaacagcgu cgccuacucc aacaacagca ucgccauccc caccaacuuc     2160

acgaucuccg ugaccaccga gauccugccc gugagcauga ccaagacgag cgucgacugc     2220

accauguaca ucugcgggga cuccaccgag ugcagcaacc uccugcugca guacggcucc     2280

uucugcaccc agcucaaccg cgcgcugacg gggaucgccg uggagcagga caagaacacc     2340

caggaggugu ucgcccaggu caagcagauc uacaagacgc ccccgaucaa ggacuucggc     2400

ggguucaacu ucagccagau ccugcccgac cccuccaagc ccagcaagcg guccuucauc     2460

gaggaccucc uguucaacaa ggugacccug gccgacgccg gcuucaucaa gcaguacggc     2520

gacugccucg gggacaucgc ggcccgcgac cugaucugcg cccagaaguu caacggccug     2580

accgugcucc cgccccugcu gaccgacgag augaucgccc aguacaccag cgcccuccug     2640

gcggggacca ucacguccgg cuggaccuuc ggggccggcg ccgcccugca gauccccuuc     2700

gcgaugcaga uggccuaccg guucaacggc aucgggguca cccagaacgu gcucuacgag     2760

aaccagaagc ugaucgccaa ccaguucaac agcgccaucg gcaagaucca ggacucccug     2820

agcuccaccg ccagcgcgcu cgggaagcug caggacgugg ucaaccagaa cgcccaggcc     2880

cugaacacgc ucgugaagca gcuguccagc aacuucggcg ccaucuccag cgugcugaac     2940

gacauccucu cccgccugga cccgcccgag gccgaggugc agaucgaccg gcugaucacc     3000

gggcgccucc agagccugca gaccuacgug acccagcagc ugauccgggc ggccgagauc     3060

cgcgccagcg ccaaccucgc cgcgaccaag auguccgagu gcguccuggg ccagagcaag     3120

cggguggacu ucugcggcaa gggguaccac cugauguccu ucccccagag cgccccgcac     3180

ggcguggucu uccuccacgu gacguacguc cccgcccagg agaagaacuu caccaccgcc     3240

cccgcgaucu gccacgacgg gaaggcccac uucccccgcg agggcguguu cguguccaac     3300

gggacccacu gguucgucac gcagcggaac uucuacgagc cgcagaucau caccaccgac     3360

aacaccuucg ugagcggcaa cugcgacgug gucaucggca ucgugaacaa cacgguguac     3420

gacccccugc agcccgagcu ggacuccuuc aaggaggagc ucgacaagua cuucaagaac     3480

cacaccagcc ccgacgucga ccugggggac aucuccggca ucaacgccag cguggugaac     3540

auccagaagg agaucgaccg ccugaacgag gucgccaaga accucaacga gucccugauc     3600

gaccugcagg agcucgggaa guacgagcag uacaucaagu ggccguggua caucuggcug     3660

ggcuucaucg ccggccugau cgcgaucgug auggugacca ucaugcucug cugcaugacc     3720

agcugcugcu ccugccugaa ggggugcugc agcugcggcu ccugcugcaa guucgacgag     3780

gacgacagcg agcccguccu gaagggggug aagcuccacu acacgugagg acuaguuaua     3840

agacugacua gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accgagauua     3900

auaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960

aaaaaaugca uccccccccc cccccccccc cccccccccc ccaaaggcuc uuuucagagc     4020

caccagaauu                                                            4030


<210>  7
<211>  4094
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R9709

<400>  7
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uucguguucc ugguccuccu gccccuggug agcucccagu      120

gcgugaaccu caccacccgc acgcagcugc cgcccgccua caccaacagc uucacccggg      180

gcgucuacua ccccgacaag guguuccgcu ccagcgugcu gcacuccacc caggaccucu      240

uccugcccuu cuucagcaac gucacguggu uccacgccau ccacgugucc gggaccaacg      300

gcaccaagcg guucgacaac ccggugcugc ccuucaacga cggggucuac uucgcgagca      360

ccgagaaguc caacaucauc cgcggcugga ucuucgggac gacccucgac agcaagaccc      420

agucccugcu gaucgugaac aacgccacca acguggucau caaggugugc gaguuccagu      480

ucugcaacga ccccuuccuc ggcguguacu accacaagaa caacaagagc uggauggagu      540

ccgaguuccg ggucuacagc uccgccaaca acugcacguu cgaguacgug agccagcccu      600

uccugaugga ccuggagggc aagcagggga acuucaagaa ccuccgcgag uucguguuca      660

agaacaucga cggcuacuuc aagaucuacu ccaagcacac cccgaucaac cugguccggg      720

accugcccca gggguucagc gcccucgagc cccuggugga ccugcccauc ggcaucaaca      780

ucacccgcuu ccagacccuc cuggcccugc accgguccua ccucacgccg ggggacagca      840

gcuccggcug gaccgcgggc gccgccgccu acuacguggg guaccugcag ccccgcaccu      900

uccugcucaa guacaacgag aacggcacca ucacggacgc ggucgacugc gcccuggacc      960

cccugagcga gaccaagugc acccucaagu ccuucaccgu ggagaagggg aucuaccaga     1020

cgagcaacuu ccgggugcag cccaccgagu ccaucguccg cuucccgaac aucaccaacc     1080

ugugccccuu cggcgaggug uucaacgcca cccgguucgc cagcgucuac gccuggaacc     1140

gcaagcggau cuccaacugc guggcggacu acagcgugcu guacaacucc gccagcuucu     1200

ccacguucaa gugcuacggc gucagcccca ccaagcucaa cgaccugugc uucaccaacg     1260

uguacgccga cuccuucgug auccgcgggg acgagguccg gcagaucgcc cccggccaga     1320

ccgggaagau cgccgacuac aacuacaagc ugccggacga cuucacgggc ugcgugaucg     1380

cguggaacag caacaaccuc gacuccaagg ucgggggcaa cuacaacuac cuguaccgcc     1440

uguuccgcaa gagcaaccuc aagcccuucg agcgggacau cuccaccgag aucuaccagg     1500

ccggcagcac ccccugcaac gggguggagg gcuucaacug cuacuucccc cugcaguccu     1560

acggguucca gccgaccaac ggcguggggu accagcccua ccgggugguc gugcugagcu     1620

ucgagcuccu gcacgccccc gccacggugu gcggccccaa gaaguccacc aaccugguca     1680

agaacaagug cgugaacuuc aacuucaacg gccucaccgg gaccggcgug cugaccgaga     1740

gcaacaagaa guuccugccg uuccagcagu ucgggcgcga caucgccgac acgaccgacg     1800

cgguccgcga cccccagacc cuggagaucc ucgacaucac ccccugcagc uucggcgggg     1860

uguccgugau cacgccgggc accaacacca gcaaccaggu cgccgugcug uaccaggacg     1920

ugaacugcac cgaggucccc guggccaucc acgccgacca gcugacgccc accuggcggg     1980

uguacuccac cggcagcaac gucuuccaga cccgcgccgg gugccucauc ggcgcggagc     2040

acgugaacaa cuccuacgag ugcgacaucc ccaucggggc cggcaucugc gccagcuacc     2100

agacgcagac caacuccccg cggcgcgccc ggagcguggc gucccagagc aucaucgccu     2160

acaccauguc ccugggcgcc gagaacagcg ucgccuacuc caacaacagc aucgccaucc     2220

ccaccaacuu cacgaucucc gugaccaccg agauccugcc cgugagcaug accaagacga     2280

gcgucgacug caccauguac aucugcgggg acuccaccga gugcagcaac cuccugcugc     2340

aguacggcuc cuucugcacc cagcucaacc gcgcgcugac ggggaucgcc guggagcagg     2400

acaagaacac ccaggaggug uucgcccagg ucaagcagau cuacaagacg cccccgauca     2460

aggacuucgg cggguucaac uucagccaga uccugcccga ccccuccaag cccagcaagc     2520

gguccuucau cgaggaccuc cuguucaaca aggugacccu ggccgacgcc ggcuucauca     2580

agcaguacgg cgacugccuc ggggacaucg cggcccgcga ccugaucugc gcccagaagu     2640

ucaacggccu gaccgugcuc ccgccccugc ugaccgacga gaugaucgcc caguacacca     2700

gcgcccuccu ggcggggacc aucacguccg gcuggaccuu cggggccggc gccgcccugc     2760

agauccccuu cgcgaugcag auggccuacc gguucaacgg caucgggguc acccagaacg     2820

ugcucuacga gaaccagaag cugaucgcca accaguucaa cagcgccauc ggcaagaucc     2880

aggacucccu gagcuccacc gccagcgcgc ucgggaagcu gcaggacgug gucaaccaga     2940

acgcccaggc ccugaacacg cucgugaagc agcuguccag caacuucggc gccaucucca     3000

gcgugcugaa cgacauccuc ucccgccugg acccgcccga ggccgaggug cagaucgacc     3060

ggcugaucac cgggcgccuc cagagccugc agaccuacgu gacccagcag cugauccggg     3120

cggccgagau ccgcgccagc gccaaccucg ccgcgaccaa gauguccgag ugcguccugg     3180

gccagagcaa gcggguggac uucugcggca agggguacca ccugaugucc uucccccaga     3240

gcgccccgca cggcgugguc uuccuccacg ugacguacgu ccccgcccag gagaagaacu     3300

ucaccaccgc ccccgcgauc ugccacgacg ggaaggccca cuucccccgc gagggcgugu     3360

ucguguccaa cgggacccac ugguucguca cgcagcggaa cuucuacgag ccgcagauca     3420

ucaccaccga caacaccuuc gugagcggca acugcgacgu ggucaucggc aucgugaaca     3480

acacggugua cgacccccug cagcccgagc uggacuccuu caaggaggag cucgacaagu     3540

acuucaagaa ccacaccagc cccgacgucg accuggggga caucuccggc aucaacgcca     3600

gcguggugaa cauccagaag gagaucgacc gccugaacga ggucgccaag aaccucaacg     3660

agucccugau cgaccugcag gagcucggga aguacgagca guacaucaag uggccguggu     3720

acaucuggcu gggcuucauc gccggccuga ucgcgaucgu gauggugacc aucaugcucu     3780

gcugcaugac cagcugcugc uccugccuga aggggugcug cagcugcggc uccugcugca     3840

aguucgacga ggacgacagc gagcccgucc ugaagggggu gaagcuccac uacacgugag     3900

gacuaguccc uguucccaga gcccacuuuu uuuucuuuuu uugaaauaaa auagccuguc     3960

uuucagaucu caaaggcucu uuucagagcc accaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaaa                                                       4094


<210>  8
<211>  4085
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R10384

<400>  8
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uucguguucc ugguccuccu gccccuggug agcucccagu      120

gcgugaacuu caccacccgc acgcagcugc cgcccgccua caccaacagc uucacccggg      180

gcgucuacua ccccgacaag guguuccgcu ccagcgugcu gcacuccacc caggaccucu      240

uccugcccuu cuucagcaac gucacguggu uccacgccau ccacgugucc gggaccaacg      300

gcaccaagcg guucgccaac ccggugcugc ccuucaacga cggggucuac uucgcgagca      360

ccgagaaguc caacaucauc cgcggcugga ucuucgggac gacccucgac agcaagaccc      420

agucccugcu gaucgugaac aacgccacca acguggucau caaggugugc gaguuccagu      480

ucugcaacga ccccuuccuc ggcguguacu accacaagaa caacaagagc uggauggagu      540

ccgaguuccg ggucuacagc uccgccaaca acugcacguu cgaguacgug agccagcccu      600

uccugaugga ccuggagggc aagcagggga acuucaagaa ccuccgcgag uucguguuca      660

agaacaucga cggcuacuuc aagaucuacu ccaagcacac cccgaucaac cugguccggg      720

gccugcccca gggguucagc gcccucgagc cccuggugga ccugcccauc ggcaucaaca      780

ucacccgcuu ccagacccuc cacaucuccu accucacgcc gggggacagc agcuccggcu      840

ggaccgcggg cgccgccgcc uacuacgugg gguaccugca gccccgcacc uuccugcuca      900

aguacaacga gaacggcacc aucacggacg cggucgacug cgcccuggac ccccugagcg      960

agaccaagug cacccucaag uccuucaccg uggagaaggg gaucuaccag acgagcaacu     1020

uccgggugca gcccaccgag uccaucgucc gcuucccgaa caucaccaac cugugccccu     1080

ucggcgaggu guucaacgcc acccgguucg ccagcgucua cgccuggaac cgcaagcgga     1140

ucuccaacug cguggcggac uacagcgugc uguacaacuc cgccagcuuc uccacguuca     1200

agugcuacgg cgucagcccc accaagcuca acgaccugug cuucaccaac guguacgccg     1260

acuccuucgu gauccgcggg gacgaggucc ggcagaucgc ccccggccag accgggaaca     1320

ucgccgacua caacuacaag cugccggacg acuucacggg cugcgugauc gcguggaaca     1380

gcaacaaccu cgacuccaag gucgggggca acuacaacua ccuguaccgc cuguuccgca     1440

agagcaaccu caagcccuuc gagcgggaca ucuccaccga gaucuaccag gccggcagca     1500

cccccugcaa cggggugaag ggcuucaacu gcuacuuccc ccugcagucc uacggguucc     1560

agccgaccua cggcgugggg uaccagcccu accggguggu cgugcugagc uucgagcucc     1620

ugcacgcccc cgccacggug ugcggcccca agaaguccac caaccugguc aagaacaagu     1680

gcgugaacuu caacuucaac ggccucaccg ggaccggcgu gcugaccgag agcaacaaga     1740

aguuccugcc guuccagcag uucgggcgcg acaucgccga cacgaccgac gcgguccgcg     1800

acccccagac ccuggagauc cucgacauca cccccugcag cuucggcggg guguccguga     1860

ucacgccggg caccaacacc agcaaccagg ucgccgugcu guaccagggc gugaacugca     1920

ccgagguccc cguggccauc cacgccgacc agcugacgcc caccuggcgg guguacucca     1980

ccggcagcaa cgucuuccag acccgcgccg ggugccucau cggcgcggag cacgugaaca     2040

acuccuacga gugcgacauc cccaucgggg ccggcaucug cgccagcuac cagacgcaga     2100

ccaacucccc gcggcgcgcc cggagcgugg cgucccagag caucaucgcc uacaccaugu     2160

cccugggcgu ggagaacagc gucgccuacu ccaacaacag caucgccauc cccaccaacu     2220

ucacgaucuc cgugaccacc gagauccugc ccgugagcau gaccaagacg agcgucgacu     2280

gcaccaugua caucugcggg gacuccaccg agugcagcaa ccuccugcug caguacggcu     2340

ccuucugcac ccagcucaac cgcgcgcuga cggggaucgc cguggagcag gacaagaaca     2400

cccaggaggu guucgcccag gucaagcaga ucuacaagac gcccccgauc aaggacuucg     2460

gcggguucaa cuucagccag auccugcccg accccuccaa gcccagcaag cgguccuuca     2520

ucgaggaccu ccuguucaac aaggugaccc uggccgacgc cggcuucauc aagcaguacg     2580

gcgacugccu cggggacauc gcggcccgcg accugaucug cgcccagaag uucaacggcc     2640

ugaccgugcu cccgccccug cugaccgacg agaugaucgc ccaguacacc agcgcccucc     2700

uggcggggac caucacgucc ggcuggaccu ucggggccgg cgccgcccug cagauccccu     2760

ucgcgaugca gauggccuac cgguucaacg gcaucggggu cacccagaac gugcucuacg     2820

agaaccagaa gcugaucgcc aaccaguuca acagcgccau cggcaagauc caggacuccc     2880

ugagcuccac cgccagcgcg cucgggaagc ugcaggacgu ggucaaccag aacgcccagg     2940

cccugaacac gcucgugaag cagcugucca gcaacuucgg cgccaucucc agcgugcuga     3000

acgacauccu cucccgccug gacccgcccg aggccgaggu gcagaucgac cggcugauca     3060

ccgggcgccu ccagagccug cagaccuacg ugacccagca gcugauccgg gcggccgaga     3120

uccgcgccag cgccaaccuc gccgcgacca agauguccga gugcguccug ggccagagca     3180

agcgggugga cuucugcggc aagggguacc accugauguc cuucccccag agcgccccgc     3240

acggcguggu cuuccuccac gugacguacg uccccgccca ggagaagaac uucaccaccg     3300

cccccgcgau cugccacgac gggaaggccc acuucccccg cgagggcgug uucgugucca     3360

acgggaccca cugguucguc acgcagcgga acuucuacga gccgcagauc aucaccaccg     3420

acaacaccuu cgugagcggc aacugcgacg uggucaucgg caucgugaac aacacggugu     3480

acgacccccu gcagcccgag cuggacuccu ucaaggagga gcucgacaag uacuucaaga     3540

accacaccag ccccgacguc gaccuggggg acaucuccgg caucaacgcc agcgugguga     3600

acauccagaa ggagaucgac cgccugaacg aggucgccaa gaaccucaac gagucccuga     3660

ucgaccugca ggagcucggg aaguacgagc aguacaucaa guggccgugg uacaucuggc     3720

ugggcuucau cgccggccug aucgcgaucg ugauggugac caucaugcuc ugcugcauga     3780

ccagcugcug cuccugccug aaggggugcu gcagcugcgg cuccugcugc aaguucgacg     3840

aggacgacag cgagcccguc cugaaggggg ugaagcucca cuacacguga ggacuagucc     3900

cuguucccag agcccacuuu uuuuucuuuu uuugaaauaa aauagccugu cuuucagauc     3960

ucaaaggcuc uuuucagagc caccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4080

aaaaa                                                                 4085


<210>  9
<211>  4070
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R10153

<400>  9
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uucguguucc ugguccuccu gccccuggug agcucccagu      120

gcgugaaccu caccacccgc acgcagcugc cgcccgccua caccaacagc uucacccggg      180

gcgucuacua ccccgacaag guguuccgcu ccagcgugcu gcacuccacc caggaccucu      240

uccugcccuu cuucagcaac gucacguggu uccacgccau ccacgugucc gggaccaacg      300

gcaccaagcg guucgacaac ccggugcugc ccuucaacga cggggucuac uucgcgagca      360

ccgagaaguc caacaucauc cgcggcugga ucuucgggac gacccucgac agcaagaccc      420

agucccugcu gaucgugaac aacgccacca acguggucau caaggugugc gaguuccagu      480

ucugcaacga ccccuuccuc ggcguguacu accacaagaa caacaagagc uggauggagu      540

ccgaguuccg ggucuacagc uccgccaaca acugcacguu cgaguacgug agccagcccu      600

uccugaugga ccuggagggc aagcagggga acuucaagaa ccuccgcgag uucguguuca      660

agaacaucga cggcuacuuc aagaucuacu ccaagcacac cccgaucaac cugguccggg      720

accugcccca gggguucagc gcccucgagc cccuggugga ccugcccauc ggcaucaaca      780

ucacccgcuu ccagacccuc cuggcccugc accgguccua ccucacgccg ggggacagca      840

gcuccggcug gaccgcgggc gccgccgccu acuacguggg guaccugcag ccccgcaccu      900

uccugcucaa guacaacgag aacggcacca ucacggacgc ggucgacugc gcccuggacc      960

cccugagcga gaccaagugc acccucaagu ccuucaccgu ggagaagggg aucuaccaga     1020

cgagcaacuu ccgggugcag cccaccgagu ccaucguccg cuucccgaac aucaccaacc     1080

ugugccccuu cggcgaggug uucaacgcca cccgguucgc cagcgucuac gccuggaacc     1140

gcaagcggau cuccaacugc guggcggacu acagcgugcu guacaacucc gccagcuucu     1200

ccacguucaa gugcuacggc gucagcccca ccaagcucaa cgaccugugc uucaccaacg     1260

uguacgccga cuccuucgug auccgcgggg acgagguccg gcagaucgcc cccggccaga     1320

ccgggaagau cgccgacuac aacuacaagc ugccggacga cuucacgggc ugcgugaucg     1380

cguggaacag caacaaccuc gacuccaagg ucgggggcaa cuacaacuac cuguaccgcc     1440

uguuccgcaa gagcaaccuc aagcccuucg agcgggacau cuccaccgag aucuaccagg     1500

ccggcagcac ccccugcaac gggguggagg gcuucaacug cuacuucccc cugcaguccu     1560

acggguucca gccgaccaac ggcguggggu accagcccua ccgggugguc gugcugagcu     1620

ucgagcuccu gcacgccccc gccacggugu gcggccccaa gaaguccacc aaccugguca     1680

agaacaagug cgugaacuuc aacuucaacg gccucaccgg gaccggcgug cugaccgaga     1740

gcaacaagaa guuccugccg uuccagcagu ucgggcgcga caucgccgac acgaccgacg     1800

cgguccgcga cccccagacc cuggagaucc ucgacaucac ccccugcagc uucggcgggg     1860

uguccgugau cacgccgggc accaacacca gcaaccaggu cgccgugcug uaccaggacg     1920

ugaacugcac cgaggucccc guggccaucc acgccgacca gcugacgccc accuggcggg     1980

uguacuccac cggcagcaac gucuuccaga cccgcgccgg gugccucauc ggcgcggagc     2040

acgugaacaa cuccuacgag ugcgacaucc ccaucggggc cggcaucugc gccagcuacc     2100

agacgcagac caacuccccg cggcgcgccc ggagcguggc gucccagagc aucaucgccu     2160

acaccauguc ccugggcgcc gagaacagcg ucgccuacuc caacaacagc aucgccaucc     2220

ccaccaacuu cacgaucucc gugaccaccg agauccugcc cgugagcaug accaagacga     2280

gcgucgacug caccauguac aucugcgggg acuccaccga gugcagcaac cuccugcugc     2340

aguacggcuc cuucugcacc cagcucaacc gcgcgcugac ggggaucgcc guggagcagg     2400

acaagaacac ccaggaggug uucgcccagg ucaagcagau cuacaagacg cccccgauca     2460

aggacuucgg cggguucaac uucagccaga uccugcccga ccccuccaag cccagcaagc     2520

gguccuucau cgaggaccuc cuguucaaca aggugacccu ggccgacgcc ggcuucauca     2580

agcaguacgg cgacugccuc ggggacaucg cggcccgcga ccugaucugc gcccagaagu     2640

ucaacggccu gaccgugcuc ccgccccugc ugaccgacga gaugaucgcc caguacacca     2700

gcgcccuccu ggcggggacc aucacguccg gcuggaccuu cggggccggc gccgcccugc     2760

agauccccuu cgcgaugcag auggccuacc gguucaacgg caucgggguc acccagaacg     2820

ugcucuacga gaaccagaag cugaucgcca accaguucaa cagcgccauc ggcaagaucc     2880

aggacucccu gagcuccacc gccagcgcgc ucgggaagcu gcaggacgug gucaaccaga     2940

acgcccaggc ccugaacacg cucgugaagc agcuguccag caacuucggc gccaucucca     3000

gcgugcugaa cgacauccuc ucccgccugg acccgcccga ggccgaggug cagaucgacc     3060

ggcugaucac cgggcgccuc cagagccugc agaccuacgu gacccagcag cugauccggg     3120

cggccgagau ccgcgccagc gccaaccucg ccgcgaccaa gauguccgag ugcguccugg     3180

gccagagcaa gcggguggac uucugcggca agggguacca ccugaugucc uucccccaga     3240

gcgccccgca cggcgugguc uuccuccacg ugacguacgu ccccgcccag gagaagaacu     3300

ucaccaccgc ccccgcgauc ugccacgacg ggaaggccca cuucccccgc gagggcgugu     3360

ucguguccaa cgggacccac ugguucguca cgcagcggaa cuucuacgag ccgcagauca     3420

ucaccaccga caacaccuuc gugagcggca acugcgacgu ggucaucggc aucgugaaca     3480

acacggugua cgacccccug cagcccgagc uggacuccuu caaggaggag cucgacaagu     3540

acuucaagaa ccacaccagc cccgacgucg accuggggga caucuccggc aucaacgcca     3600

gcguggugaa cauccagaag gagaucgacc gccugaacga ggucgccaag aaccucaacg     3660

agucccugau cgaccugcag gagcucggga aguacgagca guacaucaag uggccguggu     3720

acaucuggcu gggcuucauc gccggccuga ucgcgaucgu gauggugacc aucaugcucu     3780

gcugcaugac cagcugcugc uccugccuga aggggugcug cagcugcggc uccugcugca     3840

aguucgacga ggacgacagc gagcccgucc ugaagggggu gaagcuccac uacacgugag     3900

gacuaguccc uguucccaga gcccacuuuu uuuucuuuuu uugaaauaaa auagccuguc     3960

uuucagaucu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                4070


<210>  10
<211>  4061
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike mRNA R10452

<400>  10
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uucguguucc ugguccuccu gccccuggug agcucccagu      120

gcgugaacuu caccacccgc acgcagcugc cgcccgccua caccaacagc uucacccggg      180

gcgucuacua ccccgacaag guguuccgcu ccagcgugcu gcacuccacc caggaccucu      240

uccugcccuu cuucagcaac gucacguggu uccacgccau ccacgugucc gggaccaacg      300

gcaccaagcg guucgccaac ccggugcugc ccuucaacga cggggucuac uucgcgagca      360

ccgagaaguc caacaucauc cgcggcugga ucuucgggac gacccucgac agcaagaccc      420

agucccugcu gaucgugaac aacgccacca acguggucau caaggugugc gaguuccagu      480

ucugcaacga ccccuuccuc ggcguguacu accacaagaa caacaagagc uggauggagu      540

ccgaguuccg ggucuacagc uccgccaaca acugcacguu cgaguacgug agccagcccu      600

uccugaugga ccuggagggc aagcagggga acuucaagaa ccuccgcgag uucguguuca      660

agaacaucga cggcuacuuc aagaucuacu ccaagcacac cccgaucaac cugguccggg      720

gccugcccca gggguucagc gcccucgagc cccuggugga ccugcccauc ggcaucaaca      780

ucacccgcuu ccagacccuc cacaucuccu accucacgcc gggggacagc agcuccggcu      840

ggaccgcggg cgccgccgcc uacuacgugg gguaccugca gccccgcacc uuccugcuca      900

aguacaacga gaacggcacc aucacggacg cggucgacug cgcccuggac ccccugagcg      960

agaccaagug cacccucaag uccuucaccg uggagaaggg gaucuaccag acgagcaacu     1020

uccgggugca gcccaccgag uccaucgucc gcuucccgaa caucaccaac cugugccccu     1080

ucggcgaggu guucaacgcc acccgguucg ccagcgucua cgccuggaac cgcaagcgga     1140

ucuccaacug cguggcggac uacagcgugc uguacaacuc cgccagcuuc uccacguuca     1200

agugcuacgg cgucagcccc accaagcuca acgaccugug cuucaccaac guguacgccg     1260

acuccuucgu gauccgcggg gacgaggucc ggcagaucgc ccccggccag accgggaaca     1320

ucgccgacua caacuacaag cugccggacg acuucacggg cugcgugauc gcguggaaca     1380

gcaacaaccu cgacuccaag gucgggggca acuacaacua ccuguaccgc cuguuccgca     1440

agagcaaccu caagcccuuc gagcgggaca ucuccaccga gaucuaccag gccggcagca     1500

cccccugcaa cggggugaag ggcuucaacu gcuacuuccc ccugcagucc uacggguucc     1560

agccgaccua cggcgugggg uaccagcccu accggguggu cgugcugagc uucgagcucc     1620

ugcacgcccc cgccacggug ugcggcccca agaaguccac caaccugguc aagaacaagu     1680

gcgugaacuu caacuucaac ggccucaccg ggaccggcgu gcugaccgag agcaacaaga     1740

aguuccugcc guuccagcag uucgggcgcg acaucgccga cacgaccgac gcgguccgcg     1800

acccccagac ccuggagauc cucgacauca cccccugcag cuucggcggg guguccguga     1860

ucacgccggg caccaacacc agcaaccagg ucgccgugcu guaccagggc gugaacugca     1920

ccgagguccc cguggccauc cacgccgacc agcugacgcc caccuggcgg guguacucca     1980

ccggcagcaa cgucuuccag acccgcgccg ggugccucau cggcgcggag cacgugaaca     2040

acuccuacga gugcgacauc cccaucgggg ccggcaucug cgccagcuac cagacgcaga     2100

ccaacucccc gcggcgcgcc cggagcgugg cgucccagag caucaucgcc uacaccaugu     2160

cccugggcgu ggagaacagc gucgccuacu ccaacaacag caucgccauc cccaccaacu     2220

ucacgaucuc cgugaccacc gagauccugc ccgugagcau gaccaagacg agcgucgacu     2280

gcaccaugua caucugcggg gacuccaccg agugcagcaa ccuccugcug caguacggcu     2340

ccuucugcac ccagcucaac cgcgcgcuga cggggaucgc cguggagcag gacaagaaca     2400

cccaggaggu guucgcccag gucaagcaga ucuacaagac gcccccgauc aaggacuucg     2460

gcggguucaa cuucagccag auccugcccg accccuccaa gcccagcaag cgguccuuca     2520

ucgaggaccu ccuguucaac aaggugaccc uggccgacgc cggcuucauc aagcaguacg     2580

gcgacugccu cggggacauc gcggcccgcg accugaucug cgcccagaag uucaacggcc     2640

ugaccgugcu cccgccccug cugaccgacg agaugaucgc ccaguacacc agcgcccucc     2700

uggcggggac caucacgucc ggcuggaccu ucggggccgg cgccgcccug cagauccccu     2760

ucgcgaugca gauggccuac cgguucaacg gcaucggggu cacccagaac gugcucuacg     2820

agaaccagaa gcugaucgcc aaccaguuca acagcgccau cggcaagauc caggacuccc     2880

ugagcuccac cgccagcgcg cucgggaagc ugcaggacgu ggucaaccag aacgcccagg     2940

cccugaacac gcucgugaag cagcugucca gcaacuucgg cgccaucucc agcgugcuga     3000

acgacauccu cucccgccug gacccgcccg aggccgaggu gcagaucgac cggcugauca     3060

ccgggcgccu ccagagccug cagaccuacg ugacccagca gcugauccgg gcggccgaga     3120

uccgcgccag cgccaaccuc gccgcgacca agauguccga gugcguccug ggccagagca     3180

agcgggugga cuucugcggc aagggguacc accugauguc cuucccccag agcgccccgc     3240

acggcguggu cuuccuccac gugacguacg uccccgccca ggagaagaac uucaccaccg     3300

cccccgcgau cugccacgac gggaaggccc acuucccccg cgagggcgug uucgugucca     3360

acgggaccca cugguucguc acgcagcgga acuucuacga gccgcagauc aucaccaccg     3420

acaacaccuu cgugagcggc aacugcgacg uggucaucgg caucgugaac aacacggugu     3480

acgacccccu gcagcccgag cuggacuccu ucaaggagga gcucgacaag uacuucaaga     3540

accacaccag ccccgacguc gaccuggggg acaucuccgg caucaacgcc agcgugguga     3600

acauccagaa ggagaucgac cgccugaacg aggucgccaa gaaccucaac gagucccuga     3660

ucgaccugca ggagcucggg aaguacgagc aguacaucaa guggccgugg uacaucuggc     3720

ugggcuucau cgccggccug aucgcgaucg ugauggugac caucaugcuc ugcugcauga     3780

ccagcugcug cuccugccug aaggggugcu gcagcugcgg cuccugcugc aaguucgacg     3840

aggacgacag cgagcccguc cugaaggggg ugaagcucca cuacacguga ggacuagucc     3900

cuguucccag agcccacuuu uuuuucuuuu uuugaaauaa aauagccugu cuuucagauc     3960

uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         4061


