                         SEQUENCE LISTING

<110>  The Industry & Academic Cooperation in Chungnam National 
       University (IAC)
 
<120>  Surface engineering based adjuvanted virus vaccine

<130>  PX067908PCT

<150>  KR 10-2021-0042027
<151>  2021-03-31

<150>  KR 10-2021-0143999
<151>  2021-10-26

<160>  8     

<170>  PatentIn version 3.2

<210>  1
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  VSE peptide

<400>  1

Thr Gln Glu Val Tyr Asp Thr His Asp Cys Ala Thr Asn Gly Thr Ile 
1               5                   10                  15      


Arg Pro Phe Lys Val Leu Ser 
            20              


<210>  2
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  VSE polynucleotide

<400>  2
acccaagagg tgtacgacac ccacgactgc gccaccaacg gcaccatcag acctttcaag     60

gtgctgagc                                                             69


<210>  3
<211>  250
<212>  PRT
<213>  Artificial

<220>
<223>  VSE-human Fc peptide

<400>  3

Thr Gln Glu Val Tyr Asp Thr His Asp Cys Ala Thr Asn Gly Thr Ile 
1               5                   10                  15      


Arg Pro Phe Lys Val Leu Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  4
<211>  750
<212>  DNA
<213>  Artificial

<220>
<223>  VSE-human Fc polynucleotide

<400>  4
acccaagagg tgtacgacac ccacgactgc gccaccaacg gcaccatcag acctttcaag     60

gtgctgagcg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    120

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    180

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    240

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac    300

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    360

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    420

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag    480

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    540

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    600

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    660

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    720

cagaagagcc tctccctgtc tccgggtaaa                                     750


<210>  5
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  VSE-swine Fc peptide

<400>  5

Thr Gln Glu Val Tyr Asp Thr His Asp Cys Ala Thr Asn Gly Thr Ile 
1               5                   10                  15      


Arg Pro Phe Lys Val Leu Ser Ala Tyr Asn Thr Ala Pro Ser Val Tyr 
            20                  25                  30          


Pro Leu Ala Pro Cys Gly Arg Asp Val Ser Asp His Asn Val Ala Leu 
        35                  40                  45              


Gly Cys Leu Val Ser Ser Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
    50                  55                  60                  


Asn Ser Gly Ala Leu Ser Arg Val Val His Thr Phe Pro Ser Val Leu 
65                  70                  75                  80  


Gln Pro Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Ile Val Ala Ala 
                85                  90                  95      


Ser Ser Leu Ser Thr Leu Ser Tyr Thr Cys Asn Val Tyr His Pro Ala 
            100                 105                 110         


Thr Asn Thr Lys Val Asp Lys Arg Val Asp Ile Glu Pro Pro Thr Pro 
        115                 120                 125             


Ile Cys Pro Glu Ile Cys Ser Cys Pro Ala Ala Glu Val Leu Gly Ala 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Ile Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
                165                 170                 175     


Glu Ala Glu Val Gln Phe Ser Trp Tyr Val Asp Gly Val Gln Leu Tyr 
            180                 185                 190         


Thr Ala Gln Thr Arg Pro Met Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Lys Gly Lys 
    210                 215                 220                 


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Leu Ser Pro Ile Thr 
225                 230                 235                 240 


Arg Thr Ile Ser Lys Ala Thr Gly Pro Ser Arg Val Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ala Trp Glu Glu Leu Ser Lys Ser Lys Val Ser Ile 
            260                 265                 270         


Thr Cys Leu Val Thr Gly Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp 
        275                 280                 285             


Gln Ser Asn Gly Gln Gln Glu Pro Glu Gly Asn Tyr Arg Thr Thr Pro 
    290                 295                 300                 


Pro Gln Gln Asp Val Asp Gly Thr Tyr Phe Leu Tyr Ser Lys Leu Ala 
305                 310                 315                 320 


Val Asp Lys Val Arg Trp Gln Arg Gly Asp Leu Phe Gln Cys Ala Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Lys 
            340                 345                 350         


Thr Gln Gly Lys 
        355     


<210>  6
<211>  1068
<212>  DNA
<213>  Artificial

<220>
<223>  VSE-swine Fc polynucleotide

<400>  6
acccaagagg tgtacgacac ccacgactgc gccaccaacg gcaccatcag acctttcaag     60

gtgctgagcg cctacaacac agctccatcg gtctaccctc tggccccctg tggcagggac    120

gtgtctgatc ataacgtggc cttgggctgc cttgtctcaa gctacttccc cgagccagtg    180

accgtgacct ggaactcggg tgccctgtcc agagtcgtgc ataccttccc atccgtcctg    240

cagccgtcag ggctctactc cctcagcagc atggtgatcg tggcggccag cagcctgtcc    300

accctgagct acacgtgcaa cgtctaccac ccggccacca acaccaaggt ggacaagcgt    360

gttgacatcg aaccccccac acccatctgt cccgaaattt gctcatgccc agctgcagag    420

gtcctgggag caccgtcggt cttcctcttc cctccaaaac ccaaggacat cctcatgatc    480

tcccggacac ccaaggtcac gtgcgtggtg gtggacgtga gccaggagga ggctgaagtc    540

cagttctcct ggtacgtgga cggcgtacag ttgtacacgg cccagacgag gccaatggag    600

gagcagttca acagcaccta ccgcgtggtc agcgtcctgc ccatccagca ccaggactgg    660

ctgaagggga aggagttcaa gtgcaaggtc aacaacaaag acctcctttc ccccatcacg    720

aggaccatct ccaaggctac agggccgagc cgggtgccgc aggtgtacac cctgccccca    780

gcctgggaag agctgtccaa gagcaaagtc agcataacct gcctggtcac tggcttctac    840

ccacctgaca tcgatgtcga gtggcagagc aacggacaac aagagccaga gggcaattac    900

cgcaccaccc cgccccagca ggacgtggat gggacctact tcctgtacag caagctcgcg    960

gtggacaagg tcaggtggca gcgtggagac ctattccagt gtgcggtgat gcacgaggct   1020

ctgcacaacc actacaccca gaagtccatc tccaagactc agggtaaa                1068


<210>  7
<211>  1641
<212>  PRT
<213>  Artificial

<220>
<223>  PEDV-Fc

<400>  7

Thr Gln Glu Val Tyr Asp Thr His Asp Cys Ala Thr Asn Gly Thr Ile 
1               5                   10                  15      


Arg Pro Phe Lys Val Leu Ser Met Arg Ser Leu Ile Tyr Phe Trp Leu 
            20                  25                  30          


Leu Leu Pro Val Leu Pro Thr Leu Ser Leu Pro Gln Asp Val Thr Arg 
        35                  40                  45              


Cys Gln Ser Thr Thr Asn Phe Arg Arg Phe Phe Ser Lys Phe Asn Val 
    50                  55                  60                  


Gln Ala Pro Ala Val Val Val Leu Gly Gly Tyr Leu Pro Ser Met Asn 
65                  70                  75                  80  


Ser Ser Ser Trp Tyr Cys Gly Thr Gly Ile Glu Thr Ala Ser Gly Val 
                85                  90                  95      


His Gly Ile Phe Leu Ser Tyr Ile Asp Ser Ser Gln Gly Phe Glu Ile 
            100                 105                 110         


Gly Ile Ser Gln Glu Pro Phe Asp Pro Ser Gly Tyr Gln Leu Tyr Leu 
        115                 120                 125             


His Lys Ala Thr Asn Gly Asn Thr Asn Ala Ile Ala Arg Leu Arg Ile 
    130                 135                 140                 


Ser Gln Phe Pro Asp Asn Lys Thr Leu Gly Pro Thr Val Asn Asp Val 
145                 150                 155                 160 


Thr Thr Gly Arg Asn Cys Leu Phe Asn Lys Ala Ile Pro Ala Tyr Met 
                165                 170                 175     


Arg Asp Gly Lys Asp Ile Val Val Gly Ile Thr Trp Asp Asn Asp Arg 
            180                 185                 190         


Val Thr Val Phe Ala Asp Lys Ile Tyr His Phe Tyr Leu Lys Asn Asp 
        195                 200                 205             


Trp Ser Arg Val Ala Thr Arg Cys Tyr Asn Arg Arg Ser Cys Ala Met 
    210                 215                 220                 


Gln Tyr Val Tyr Thr Pro Thr Tyr Tyr Met Leu Asn Val Thr Ser Ala 
225                 230                 235                 240 


Gly Glu Asp Gly Ile Tyr Tyr Glu Pro Cys Thr Ala Asn Cys Thr Gly 
                245                 250                 255     


Tyr Ala Ala Asn Val Phe Ala Thr Asp Ser Asn Gly His Ile Pro Glu 
            260                 265                 270         


Ser Phe Ser Phe Asn Asn Trp Phe Leu Leu Ser Asn Asp Ser Thr Leu 
        275                 280                 285             


Leu His Gly Lys Val Val Ser Asn Gln Pro Leu Leu Val Asn Cys Leu 
    290                 295                 300                 


Leu Ala Ile Pro Lys Ile Tyr Gly Leu Gly Gln Phe Phe Ser Phe Asn 
305                 310                 315                 320 


His Thr Met Asp Gly Val Cys Asn Gly Ala Ala Leu Asp Arg Ala Pro 
                325                 330                 335     


Glu Ala Leu Arg Phe Asn Ile Asn Asp Thr Ser Val Ile Leu Ala Glu 
            340                 345                 350         


Gly Ser Ile Val Leu His Thr Ala Leu Gly Thr Asn Leu Ser Phe Val 
        355                 360                 365             


Cys Ser Asn Ser Ser Asp Pro His Leu Ala Thr Phe Ala Ile Pro Leu 
    370                 375                 380                 


Gly Ala Thr Glu Val Pro Tyr Tyr Cys Phe Leu Ile Val Asp Thr Tyr 
385                 390                 395                 400 


Asn Ser Thr Val Tyr Lys Phe Leu Ala Val Leu Pro Pro Thr Val Arg 
                405                 410                 415     


Glu Ile Val Ile Thr Lys Tyr Gly Asp Val Tyr Val Asn Gly Phe Gly 
            420                 425                 430         


Tyr Leu His Leu Gly Leu Leu Asp Ala Val Thr Ile Asn Phe Thr Gly 
        435                 440                 445             


His Gly Thr Asp Asp Asp Val Ser Gly Phe Trp Thr Ile Asp Ser Thr 
    450                 455                 460                 


Asn Phe Val Asp Ala Leu Ile Glu Val Gln Gly Thr Ser Ile Gln Arg 
465                 470                 475                 480 


Ile Leu Tyr Cys Asp Asp Pro Val Ser Gln Leu Lys Cys Ser Gln Val 
                485                 490                 495     


Ala Phe Asp Leu Asp Asp Gly Phe Tyr Pro Ile Ser Ser Arg Asn Leu 
            500                 505                 510         


Leu Ser His Glu Gln Pro Ile Ser Phe Val Thr Leu Pro Ser Phe Asn 
        515                 520                 525             


Asp His Ser Phe Val Asn Ile Thr Val Ser Ala Ser Phe Gly Asp His 
    530                 535                 540                 


Ser Gly Ala Asn Leu Val Ala Ser Asp Thr Thr Ile Asn Gly Phe Ser 
545                 550                 555                 560 


Ser Phe Cys Val Asp Thr Arg Gln Phe Thr Ile Arg Leu Phe Tyr Asn 
                565                 570                 575     


Val Thr Ser Ser Tyr Gly Tyr Val Ser Lys Ser Gln Tyr Ser Asn Cys 
            580                 585                 590         


Pro Phe Thr Leu Gln Ser Val Asn Asp Tyr Leu Ser Phe Ser Lys Phe 
        595                 600                 605             


Cys Val Ser Thr Ser Leu Leu Ala Ser Ala Cys Thr Ile Asp Leu Phe 
    610                 615                 620                 


Gly Tyr Pro His Phe Gly Ser Gly Val Lys Phe Thr Ser Leu Tyr Phe 
625                 630                 635                 640 


Gln Phe Thr Glu Gly Glu Leu Ile Thr Gly Thr Pro Lys Pro Leu Glu 
                645                 650                 655     


Gly Val Thr Asp Val Ser Phe Met Thr Leu Asp Val Cys Thr Lys Tyr 
            660                 665                 670         


Thr Ile Tyr Gly Phe Lys Gly Glu Gly Ile Ile Thr Leu Thr Asn Ser 
        675                 680                 685             


Ser Phe Leu Ala Gly Val Tyr Tyr Thr Ser Asp Ser Gly Gln Leu Leu 
    690                 695                 700                 


Ala Phe Lys Asn Val Thr Ser Gly Ala Val Tyr Ser Val Thr Pro Cys 
705                 710                 715                 720 


Ser Phe Ser Glu Gln Ala Ala Tyr Val Asp Asp Asp Ile Val Gly Val 
                725                 730                 735     


Ile Ser Ser Leu Ser Asn Ser Thr Phe Asn Asn Thr Arg Glu Leu Pro 
            740                 745                 750         


Gly Phe Phe Tyr His Ser Asn Asp Gly Ser Asn Cys Thr Glu Pro Val 
        755                 760                 765             


Leu Val Tyr Ser Asn Ile Gly Val Cys Lys Ser Gly Ser Ile Gly Tyr 
    770                 775                 780                 


Val Pro Ser Gln Ser Gly Gln Val Lys Ile Ala Pro Thr Val Thr Gly 
785                 790                 795                 800 


Asn Ile Ser Ile Pro Thr Asn Phe Ser Met Ser Ile Arg Thr Glu Tyr 
                805                 810                 815     


Leu Gln Leu Tyr Asn Thr Pro Val Ser Val Asp Cys Ala Thr Tyr Val 
            820                 825                 830         


Cys Asn Gly Asn Ser Arg Cys Lys Gln Leu Leu Thr Gln Tyr Thr Ala 
        835                 840                 845             


Ala Cys Lys Thr Ile Glu Ser Ala Leu Gln Leu Ser Ala Arg Leu Glu 
    850                 855                 860                 


Ser Val Glu Val Asn Ser Met Leu Thr Thr Ser Glu Gln Ala Leu Gln 
865                 870                 875                 880 


Leu Ala Thr Ile Ser Ser Phe Asn Gly Asp Gly Tyr Asn Phe Thr Asn 
                885                 890                 895     


Val Leu Gly Val Ser Val Tyr Asp Pro Ala Ser Gly Arg Val Val His 
            900                 905                 910         


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Val Thr Asn 
        915                 920                 925             


Gly Leu Gly Thr Val Asp Glu Asp Tyr Lys Arg Cys Ser Asn Gly Arg 
    930                 935                 940                 


Ser Val Ala Asp Leu Val Cys Ala Gln Tyr Tyr Ser Gly Val Met Val 
945                 950                 955                 960 


Leu Pro Gly Val Val Asp Ala Glu Lys Leu His Met Tyr Ser Ala Ser 
                965                 970                 975     


Leu Ile Gly Gly Met Val Leu Gly Gly Phe Thr Ala Ala Ala Ala Leu 
            980                 985                 990         


Pro Phe Ser Tyr Ala Val Gln Ala  Arg Leu Asn Tyr Leu  Ala Leu Gln 
        995                 1000                 1005             


Thr Asp  Val Leu Gln Arg Asn  Gln Gln Leu Leu Ala  Glu Ser Phe 
    1010                 1015                 1020             


Asn Ser  Ala Ile Gly Asn Ile  Thr Ser Ala Phe Glu  Ser Val Lys 
    1025                 1030                 1035             


Glu Ala  Ile Ser Gln Thr Ser  Gln Gly Leu Asn Thr  Val Ala Arg 
    1040                 1045                 1050             


Ala Leu  Thr Lys Val Gln Glu  Val Val Asn Ser Gln  Gly Ala Ala 
    1055                 1060                 1065             


Leu Thr  Gln Leu Thr Val Gln  Leu Gln His Asn Phe  Gln Ala Ile 
    1070                 1075                 1080             


Ser Ser  Ser Ile Asp Asp Ile  Tyr Ser Arg Leu Asp  Ile Leu Ser 
    1085                 1090                 1095             


Ala Asp  Val Gln Val Asp Arg  Leu Ile Thr Gly Arg  Leu Ser Ala 
    1100                 1105                 1110             


Leu Asn  Ala Phe Val Ala Gln  Thr Leu Thr Lys Tyr  Thr Glu Val 
    1115                 1120                 1125             


Gln Ala  Ser Arg Lys Leu Ala  Gln Gln Lys Val Asn  Glu Cys Val 
    1130                 1135                 1140             


Lys Ser  Gln Ser Gln Arg Tyr  Gly Phe Cys Gly Gly  Asp Gly Glu 
    1145                 1150                 1155             


His Ile  Phe Ser Leu Val Gln  Ala Ala Pro Gln Gly  Leu Leu Phe 
    1160                 1165                 1170             


Leu His  Thr Val Leu Val Pro  Gly Asp Phe Val Asn  Val Ile Ala 
    1175                 1180                 1185             


Ile Ala  Gly Leu Cys Val Asn  Gly Asp Ile Ala Leu  Thr Leu Arg 
    1190                 1195                 1200             


Glu Pro  Gly Leu Val Leu Phe  Thr His Glu Leu Gln  Thr His Thr 
    1205                 1210                 1215             


Ala Thr  Glu Tyr Phe Val Ser  Ser Arg Arg Met Phe  Glu Leu Arg 
    1220                 1225                 1230             


Lys Pro  Thr Val Ser Asp Phe  Val Gln Ile Glu Ser  Cys Val Val 
    1235                 1240                 1245             


Thr Tyr  Val Asn Leu Thr Ser  Asp Gln Leu Pro Asp  Val Ile Pro 
    1250                 1255                 1260             


Asp Tyr  Ile Asp Val Asn Lys  Thr Leu Asp Glu Ile  Leu Ala Ser 
    1265                 1270                 1275             


Leu Pro  Asn Arg Thr Gly Pro  Ser Leu Pro Leu Asp  Val Phe Asn 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Asn Leu Thr  Gly Glu Ile Ala Asp  Leu Glu Gln 
    1295                 1300                 1305             


Arg Ser  Glu Ser Leu Gln Asn  Thr Thr Glu Glu Leu  Arg Thr Leu 
    1310                 1315                 1320             


Ile Tyr  Asn Ile Asn Asn Thr  Leu Val Asp Leu Glu  Trp Leu Asn 
    1325                 1330                 1335             


Arg Val  Glu Thr Tyr Ile Lys  Trp Pro Trp Trp Ile  Trp Leu Ile 
    1340                 1345                 1350             


Ile Phe  Ile Val Leu Ile Phe  Val Val Ser Leu Leu  Val Phe Cys 
    1355                 1360                 1365             


Cys Ile  Ser Thr Gly Cys Cys  Gly Cys Cys Gly Cys  Cys Gly Ala 
    1370                 1375                 1380             


Cys Phe  Ser Gly Cys Cys Arg  Gly Pro Arg Leu Gln  Pro Tyr Glu 
    1385                 1390                 1395             


Ala Phe  Glu Lys Val His Val  Gln Asp Ile Glu Pro  Pro Thr Pro 
    1400                 1405                 1410             


Ile Cys  Pro Glu Ile Cys Ser  Cys Pro Ala Ala Glu  Val Leu Gly 
    1415                 1420                 1425             


Ala Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Ile Leu 
    1430                 1435                 1440             


Met Ile  Ser Arg Thr Pro Lys  Val Thr Cys Val Val  Val Asp Val 
    1445                 1450                 1455             


Ser Gln  Glu Glu Ala Glu Val  Gln Phe Ser Trp Tyr  Val Asp Gly 
    1460                 1465                 1470             


Val Gln  Leu Tyr Thr Ala Gln  Thr Arg Pro Met Glu  Glu Gln Phe 
    1475                 1480                 1485             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Pro Ile  Gln His Gln 
    1490                 1495                 1500             


Asp Trp  Leu Lys Gly Lys Glu  Phe Lys Cys Lys Val  Asn Asn Lys 
    1505                 1510                 1515             


Asp Leu  Leu Ser Pro Ile Thr  Arg Thr Ile Ser Lys  Ala Thr Gly 
    1520                 1525                 1530             


Pro Ser  Arg Val Pro Gln Val  Tyr Thr Leu Pro Pro  Ala Trp Glu 
    1535                 1540                 1545             


Glu Leu  Ser Lys Ser Lys Val  Ser Ile Thr Cys Leu  Val Thr Gly 
    1550                 1555                 1560             


Phe Tyr  Pro Pro Asp Ile Asp  Val Glu Trp Gln Ser  Asn Gly Gln 
    1565                 1570                 1575             


Gln Glu  Pro Glu Gly Asn Tyr  Arg Thr Thr Pro Pro  Gln Gln Asp 
    1580                 1585                 1590             


Val Asp  Gly Thr Tyr Phe Leu  Tyr Ser Lys Leu Ala  Val Asp Lys 
    1595                 1600                 1605             


Val Arg  Trp Gln Arg Gly Asp  Leu Phe Gln Cys Ala  Val Met His 
    1610                 1615                 1620             


Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Ile  Ser Lys Thr 
    1625                 1630                 1635             


Gln Gly  Lys 
    1640     


<210>  8
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  PRRSV-Fc

<400>  8

Thr Gln Glu Val Tyr Asp Thr His Asp Cys Ala Thr Asn Gly Thr Ile 
1               5                   10                  15      


Arg Pro Phe Lys Val Leu Ser Met Leu Glu Lys Cys Leu Thr Ala Gly 
            20                  25                  30          


Cys Tyr Ser Gln Leu Leu Ser Leu Trp Cys Ile Val Pro Phe Cys Phe 
        35                  40                  45              


Ala Val Leu Val Asn Ala Ala Pro Lys Thr Ala Pro Ser Val Tyr Pro 
    50                  55                  60                  


Leu Ala Pro Cys Gly Arg Asp Val Ser Gly Pro Asn Val Ala Leu Gly 
65                  70                  75                  80  


Cys Leu Ala Ser Ser Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                85                  90                  95      


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
            100                 105                 110         


Pro Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ala Ser 
        115                 120                 125             


Ser Leu Ser Ser Lys Ser Tyr Thr Cys Asn Val Asn His Pro Ala Thr 
    130                 135                 140                 


Thr Thr Lys Val Asp Lys Arg Val Gly Ile His Gln Pro Gln Thr Cys 
145                 150                 155                 160 


Pro Cys Pro Gly Cys Glu Val Ala Gly Pro Ser Val Phe Ile Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Gln Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser Lys Glu His Ala Glu Val Gln Phe Ser 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Thr Ala Glu Thr Arg Pro Lys 
    210                 215                 220                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
225                 230                 235                 240 


Gln His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
                245                 250                 255     


Asn Val Asp Leu Pro Ala Pro Ile Thr Arg Thr Ile Ser Lys Ala Ile 
            260                 265                 270         


Gly Gln Ser Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Pro Ala Glu 
        275                 280                 285             


Glu Leu Ser Arg Ser Lys Val Thr Leu Thr Cys Leu Val Ile Gly Phe 
    290                 295                 300                 


Tyr Pro Pro Asp Ile His Val Glu Trp Lys Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Pro Glu Asn Thr Tyr Arg Thr Thr Pro Pro Gln Gln Asp Val Asp Gly 
                325                 330                 335     


Thr Phe Phe Leu Tyr Ser Lys Leu Ala Val Asp Lys Ala Arg Trp Asp 
            340                 345                 350         


His Gly Asp Lys Phe Glu Cys Ala Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Ile Ser Lys Thr Gln Gly Lys Tyr Val Leu 
    370                 375                 380                 


Ser Ser Ile Tyr Ala Val Cys Ala Leu Ala Ala Leu Thr Cys Phe Val 
385                 390                 395                 400 


Ile Arg Phe Ala Lys Asn Cys Met Ser Trp Arg Tyr Ala Cys Thr Arg 
                405                 410                 415     


Tyr Thr Asn Phe Leu Leu Asp Thr Lys Gly Arg Leu Tyr Arg Trp Arg 
            420                 425                 430         


Ser Pro Val Ile Ile Glu Lys Arg Gly Lys Val Glu Val Glu Gly His 
        435                 440                 445             


Leu Ile Asp Leu Lys Arg Val Val Leu Asp Gly Ser Val Ala Thr Pro 
    450                 455                 460                 


Ile Thr Arg Val Ser Ala Glu Gln Trp Gly Arg Pro 
465                 470                 475     


