                         SEQUENCE LISTING

<110>  JAZZ PHARMACEUTICALS IRELAND LTD.
	Choi, Mi Rim
	Lin, Tong
	Silverman, Jeffrey
 
<120>  DOSING OF RECOMBINANT L-ASPARAGINASE

<130>  49170-4005

<150>  63/168,224
<151>  2021-03-30

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  recombinant L-asparaginase

<400>  1

Ala Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr Ile 
1               5                   10                  15      


Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala Gly 
            20                  25                  30          


Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys Lys 
        35                  40                  45              


Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Glu Asn 
    50                  55                  60                  


Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu Leu 
65                  70                  75                  80  


Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr Asp 
                85                  90                  95      


Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser Asp 
            100                 105                 110         


Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile Ser 
        115                 120                 125             


Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly Asp 
    130                 135                 140                 


Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg Ile 
145                 150                 155                 160 


Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp Thr 
                165                 170                 175     


Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn Arg 
            180                 185                 190         


Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser Val 
        195                 200                 205             


Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu Tyr 
    210                 215                 220                 


Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln His 
225                 230                 235                 240 


Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val Ser 
                245                 250                 255     


Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val Val 
            260                 265                 270         


Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp Glu 
        275                 280                 285             


Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala Arg 
    290                 295                 300                 


Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val Ile 
305                 310                 315                 320 


Gln Glu Tyr Phe His Thr Tyr 
                325         


<210>  2
<211>  20
<212>  PRT
<213>  synthetic peptide

<400>  2

Ala Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ala 
            20  


<210>  3
<211>  348
<212>  PRT
<213>  native E. coli-derived L-asparaginase

<400>  3

Met Glu Phe Phe Lys Lys Thr Ala Leu Ala Ala Leu Val Met Gly Phe 
1               5                   10                  15      


Ser Gly Ala Ala Leu Ala Leu Pro Asn Ile Thr Ile Leu Ala Thr Gly 
            20                  25                  30          


Gly Thr Ile Ala Gly Gly Gly Asp Ser Ala Thr Lys Ser Asn Tyr Thr 
        35                  40                  45              


Val Gly Lys Val Gly Val Glu Asn Leu Val Asn Ala Val Pro Gln Leu 
    50                  55                  60                  


Lys Asp Ile Ala Asn Val Lys Gly Glu Gln Val Val Asn Ile Gly Ser 
65                  70                  75                  80  


Gln Asp Met Asn Asp Asn Val Trp Leu Thr Leu Ala Lys Lys Ile Asn 
                85                  90                  95      


Thr Asp Cys Asp Lys Thr Asp Gly Phe Val Ile Thr His Gly Thr Asp 
            100                 105                 110         


Thr Met Glu Glu Thr Ala Tyr Phe Leu Asp Leu Thr Val Lys Cys Asp 
        115                 120                 125             


Lys Pro Val Val Met Val Gly Ala Met Arg Pro Ser Thr Ser Met Ser 
    130                 135                 140                 


Ala Asp Gly Pro Phe Asn Leu Tyr Asn Ala Val Val Thr Ala Ala Asp 
145                 150                 155                 160 


Lys Ala Ser Ala Asn Arg Gly Val Leu Val Val Met Asn Asp Thr Val 
                165                 170                 175     


Leu Asp Gly Arg Asp Val Thr Lys Thr Asn Thr Thr Asp Val Ala Thr 
            180                 185                 190         


Phe Lys Ser Val Asn Tyr Gly Pro Leu Gly Tyr Ile His Asn Gly Lys 
        195                 200                 205             


Ile Asp Tyr Gln Arg Thr Pro Ala Arg Lys His Thr Ser Asp Thr Pro 
    210                 215                 220                 


Phe Asp Val Ser Lys Leu Asn Glu Leu Pro Lys Val Gly Ile Val Tyr 
225                 230                 235                 240 


Asn Tyr Ala Asn Ala Ser Asp Leu Pro Ala Lys Ala Leu Val Asp Ala 
                245                 250                 255     


Gly Tyr Asp Gly Ile Val Ser Ala Gly Val Gly Asn Gly Asn Leu Tyr 
            260                 265                 270         


Lys Ser Val Phe Asp Thr Leu Ala Thr Ala Ala Lys Thr Gly Thr Ala 
        275                 280                 285             


Val Val Arg Ser Ser Arg Val Pro Thr Gly Ala Thr Thr Gln Asp Ala 
    290                 295                 300                 


Glu Val Asp Asp Ala Lys Tyr Gly Phe Val Ala Ser Gly Thr Leu Asn 
305                 310                 315                 320 


Pro Gln Lys Ala Arg Val Leu Leu Gln Leu Ala Leu Thr Gln Thr Lys 
                325                 330                 335     


Asp Pro Gln Gln Ile Gln Gln Ile Phe Asn Gln Tyr 
            340                 345             


