                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Guo, Chunguang
       Tu, Naxin
       Murphy, Andrew J.
 
<120>  GENETICALLY MODIFIED MICE COMPRISING HUMANIZED CELLULAR IMMUNE 
       SYSTEM COMPONENTS WITH IMPROVED DIVERSITY OF TCRB REPERTOIRE

<130>  009108.948WO1/10948WO01

<150>  63/168,774
<151>  2021-03-31

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
cagaacgcca ggctgtaac                                                    19


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2
ggagagcagg gtcagtcaac                                                   20


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
caccgccact cacagctcct taca                                              24


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
gtgggcacca tcttcatcat tc                                                22


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
cttcctttcc agggtgtgac tc                                                22


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
aggcctgcga tcaggtggca cct                                               23


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
ggtggagagg ctattcggc                                                    19


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
gaacacggcg gcatcag                                                      17


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
tgggcacaac agacaatcgg ctg                                               23


<210>  10
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
tttgtaaaca aagtctaccc agagacagat gacagacttc agctccaatg ctgattggtt       60

cctcacttgg gaccaaccct accggtataa cttcgtataa ggtatcctat acgaagttat      120

atgcatggcc tccgcgccgg                                                  140


<210>  11
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
cgacctgcag ccggcgcgcc ataacttcgt ataaggtatc ctatacgaag ttatctcgag       60

cacaggcatt tgggtgggca gggatggacg gtgactggga caatcgggat ggaagagcat      120

agaatgggag ttagggaaga                                                  140


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
cgaggagccc cggtaca                                                      17


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
aagcgcacga actccttgtt                                                   20


<210>  14
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
ctctgtcggc tatgtgg                                                      17


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
ggactcccag aatctcctga ga                                                22


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
gagtcatgaa ccatcactgt gaaga                                             25


<210>  17
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
tggtgggttg ctggaa                                                       16


<210>  18
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
ctgtttcttc cctaactccc attctatgct cttccatccc gaccgcggcc caatctctct       60

ccactacttc ctgcctacat gtatgtaggt                                        90


<210>  19
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
caaggtttcc tcctatgatg cttgtgtgaa actcggggcc ggccagcatt taacagtaca       60

gggatgggag cacagctcac                                                   80


<210>  20
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
gaaagcagtc ttcccagcct tcacactcag aggtacaaat ccccattttc atattagcga       60

ttttaattta ttctagcctc                                                   80


<210>  21
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
tcttccctaa ctcccattct atgctcttcc atcccgaccg cggcccaatc tctctccact       60

acttcctgcc tacatgtatg                                                   80


<210>  22
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
gagttcctcc atcacttcac tgggtagcac agctgtaact gtccagcctg tcctgggctg       60

caggtggtgg gcgttgcggg tggggccggt taaggttcca                            100


<210>  23
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
tcccacatcc tattttaatt tgctccatgt tctcatctcc atcagcacag ctcgagataa       60

cttcgtataa tgtatgctat acgaagttat atgcatggcc                            100


<210>  24
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
atacgaagtt atgctagtaa ctataacggt cctaaggtag cgagtggctt acaggtaggt       60

gcgtgaagct tctacaagca cagttgcccc ctgggaagca                            100


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
tgcggccgat cttagcc                                                      17


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
ttgaccgatt ccttgcgg                                                     18


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
acgagcgggt tcggcccatt c                                                 21


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
ccccacagca cgtttcct                                                     18


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
cgtcccattg aagaaatgac act                                               23


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
tggcagccta agagg                                                        15


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
ccccacagca cgtttcct                                                     18


<210>  32
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32
acccgctccg tcccatt                                                      17


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
agcctaagag ggagtgtc                                                     18


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
agaccctggt gatgctggaa                                                   20


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
cgcttgggtg ctccactt                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36
tcgaagtgga gaggttta                                                     18


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
tggaatggag tgagcagctt t                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38
gcacggtccc cttcttagtg                                                   20


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
tgacttccta aatttctc                                                     18


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40
ctggcggctt gaagaatttg g                                                 21


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
catgatttcc aggttggctt tgtc                                              24


<210>  42
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42
cgatttgcca gctttgaggc tcaagg                                            26


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
cctcacttgg gaccaaccct a                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44
ttgtcccagt caccgtccat                                                   20


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
tgcatctcga gcacaggcat ttgg                                              24


<210>  46
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg ggtaccgggc       60

cccccctcga ggtcgacata acttcgtata gcatacatta                            100


<210>  47
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
ggccatgcat ataacttcgt atagcataca ttatacgaag ttataccggt gcgatcgcgc       60

gcttccctct tctaaccact aattcaaaaa ggattgtaag taatgttt                   108


<210>  48
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
agacagaccc ctaaacacct ccaaattaaa agcggcaaag agataaggtt ggagctccac       60

cgcggtggcg gccgccaccg cggtggagct cgaggtttcc ggtacttaac aacagagcac      120

agatttagtg gtgagggact ctctc                                            145


<210>  49
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg ggtaccgggc       60

cccccctcga ggtcgacata acttcgtata gcatacatta                            100


<210>  50
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
ggccatgcat ataacttcgt atagcataca ttatacgaag ttataccggt gcgatcgctc       60

aagcatgcaa gggtaacata tgttatgaga ttatattttc tttatctca                  109


<210>  51
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg gggtaccggg       60

ccccccctcg agaagttcct attccgaagt tcctattctc                            100


<210>  52
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
gttcctattc cgaagttcct attctctaga aagtatagga acttcctagg gcgatcgctc       60

ctctccaggc tcgaattagt attacagttg aggcacgttg tcctcccg                   108


<210>  53
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg ggtaccgggc       60

cccccctcga ggtcgacata acttcgtata gcatacatta                            100


<210>  54
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
ggccatgcat ataacttcgt atagcataca ttatacgaag ttataccggt gcgatcgccg       60

cctccatttc cttcatagga aacatgaagt gaatggggct gtgtgtgt                   108


<210>  55
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg ggtaccgggc       60

cccccctcga ggtcgacata acttcgtata gcatacatta                            100


<210>  56
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
ggccatgcat ataacttcgt atagcataca ttatacgaag ttataccggt gcgatcgctg       60

ggagcacgtt ccattattat aacaactttc tgaacacaag agggcagt                   108


<210>  57
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
atggagtagt cagaacacac tcttcagaag ggactcctga tttcaaaggg ggtaccgggc       60

cccccctcga ggtcgacata acttcgtata gcatacatta                            100


<210>  58
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
ggccatgcat ataacttcgt atagcataca ttatacgaag ttataccggt gcgatcgctt       60

taaggtgagg aggcaggcaa taccccctct ccaccgcatt ctcaatcc                   108


<210>  59
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
gggggggtgg ggtggaggag gagggtacag catctcctct ccttcctctc tggtaccgaa       60

gttcctattc cgaagttcct attctctaga aagtatagga                            100


<210>  60
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
gaagttccta ttctctagaa agtataggaa cttcctaggg tttcaccggt gcgatcgcgt       60

gaatatacta aaaaccactt aattatatat ttgaaagggt ggatgtta                   108


<210>  61
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
ctctctccta cccagctcct ctcacacgag cctgaaggcc ctgccaaggt ggcgcgcctt       60

tcaaattgtt gttgagttca aagtgggcaa cagaaaaggg ggtgtgag                   108


<210>  62
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
aataaatagt aaatttctgt agaatcataa tgaggtctag acccccgggc tcgataacta       60

taacggtcct aaggtagcga aatggcgcgt aatcaagccc agctcttcat gctgcatttt      120

tatcttcttt                                                             130


<210>  63
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
ttgactcggg ggtgcctggg tttgactgca atgatcagtt gctgggaagg accggtataa       60

cttcgtataa tgtatgctat acgaagttat atgcatggcc                            100


<210>  64
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
ccggcgcgcc ataacttcgt ataatgtatg ctatacgaag ttatgtcgac ataaggtaag       60

acagagtcgt cccttcccat ctggaaccct ctacctttct                            100


<210>  65
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
gttgatgaat cataaaagaa gagatattca agaaaaggat ggccacactg cggccgcaga       60

ggtattcaag gaaaatgcag actcttcacg taagagggat gaggggc                    107


<210>  66
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66
tccccggagt cggagggtgg accggagctg gaggagctgc cgcggtggcg gccgatgcca       60

tttcattacc tctttctccg cacccgacat agataaagct                            100


<210>  67
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67
gggggggtgg ggtggaggag gagggtacag catctcctct ccttcctctc tggtaccgaa       60

gttcctattc cgaagttcct attctctaga aagtatagga                            100


<210>  68
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68
gaagttccta ttctctagaa agtataggaa cttcctaggg tttcaccggt gcgatcgcga       60

agcaattaac tgcccctggt ccagttgcct cctctgataa tgcattgt                   108


<210>  69
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69
gggggggtgg ggtggaggag gagggtacag catctcctct ccttcctctc tggtaccgaa       60

gttcctattc cgaagttcct attctctaga aagtatagga                            100


<210>  70
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70
gaagttccta ttctctagaa agtataggaa cttcctaggg tttcaccggt gcgatcgcgt       60

tatctagtag acttaattaa ggatcgatcc ggcgcgccaa tagtcatg                   108


<210>  71
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71
gttttccaga cttcaacttg actatcagcc agaaattcag tggcaaaccc ccacccagtc       60

cctaagtgaa ggcccctggg gagtatggtt agggctcagg                            100


<210>  72
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72
cacccaccaa agaaagtgcc caggagaagg gcaaggagag agcagagcat agttcaagat       60

ggtctttgtc taggcttgtc tactctgcac ttgtacttcc                            100


<210>  73
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73
aggggaaacc cgcaaaggat gggacatagg gagacagctg ttaacatctg aaacatgacc       60

ttcttttctg tgcagcacaa ctcctagctg tcactcaagg gaagaaagtg gtgctgggca      120

aaaaagggga tacagtggaa ctgacctgta cagcttccca gaagaagagc atacaattcc      180

actggaaaaa ctccaaccag at                                               202


<210>  74
<211>  240
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74
ctggtcacct ggatgaagtg agggagggcc ctctgggttt ggggctggtt ttgaactgag       60

acatccatga gccagcctgg ggctggcttc actgaagatc atctatgtcg ggtgcggaga      120

aagaggtaat gaaatggcac atgctatgta caaactctat tgctgagcag cacccagtcc      180

tgagctggct ctgaattgag ggtgaaattc acacattctc ccccaacatc tataatctgg      240


<210>  75
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75
tatggagtga aagcctttgg tgtctgagat ctggtcttag ttaaactctg ggatcggcgc       60

gccgaattcc tgcagcccgg gctcgagata acttcgtata atgtatgcta tacgaagtta      120

tatgcatccg ggtaggggag gcgcttttcc c                                     151


<210>  76
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76
agtattgttt tgccaagttc taattccatc agacctcgac ctgcagccct agataacttc       60

gtataatgta tgctatacga agttatccta ggccagaggg cttgggttga cagaaactca      120

gtggcattct tatccagagt ttctctacac c                                     151


<210>  77
<211>  18263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (2957)..(2957)
<223>  n = A,T,C or G

<220>
<221>  misc_feature
<222>  (3193)..(3193)
<223>  n = A,T,C or G

<400>  77
aagaaagtgg tgctgggcaa aaaaggggat acagtggaac tgacctgtac agcttcccag       60

aagaagagca tacaattcca ctggaaaaac tccaaccaga taaagattct gggaaatcag      120

ggctccttct taactaaagg tagggttgcc tggctcccca tccagggagg aaaacacact      180

atggagtgaa agcctttggt gtctgagatc tggtcttagt taaactctgg gatcggcgcg      240

ccgaattcct gcagcccggg ctcgagataa cttcgtataa tgtatgctat acgaagttat      300

atgcatccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc      360

cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac      420

cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc      480

cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga      540

agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt      600

aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct      660

gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg      720

aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt      780

ctcctcttcc tcatctccgg gcctttcgac ctgcagccaa ttgttgacaa ttaatcatcg      840

gcatagtata tcggcatagt ataatacgac aaggtgagga actaaaccat gggatcggcc      900

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc      960

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     1020

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag     1080

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     1140

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     1200

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     1260

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     1320

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     1380

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc     1440

gatgatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     1500

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     1560

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     1620

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     1680

gagttcttct gaggggatcc gctgtaagtc tgcagaaatt gatgatctat taaacaataa     1740

agatgtccac taaaatggaa gtttttcctg tcatactttg ttaagaaggg tgagaacaga     1800

gtacctacat tttgaatgga aggattggag ctacgggggt gggggtgggg tgggattaga     1860

taaatgcctg ctctttactg aaggctcttt actattgctt tatgataatg tttcatagtt     1920

ggatatcata atttaaacaa gcaaaaccaa attaagggcc agctcattcc tcccactcat     1980

gatctataga tctatagatc tctcgtggga tcattgtttt tctcttgatt cccactttgt     2040

ggttctaagt actgtggttt ccaaatgtgt cagtttcata gcctgaagaa cgagatcagc     2100

agcctctgtt ccacatacac ttcattctca gtattgtttt gccaagttct aattccatca     2160

gacctcgacc tgcagcccta gataacttcg tataatgtat gctatacgaa gttatcctag     2220

gccagagggc ttgggttgac agaaactcag tggcattctt atccagagtt tctctacacc     2280

aactgctggt ggcccaggga aaggtggtat gtgaatttca atattttaat atttaatatt     2340

catgaactta ttttagtgag ttttagaaca atcactatca cttaaaaccc gtgatttctt     2400

gagtattgtt gctacagacc tatgtagata atactttgca cagtgactca tatgtataat     2460

cctagcactg tgggaggctg aggccggagg attgcttgag tccaggagtt caagaccagc     2520

ctgaacaaca tagtgagact ctgtctctat gaaaaaaaat atatatatat tttttttgga     2580

gacaaggtct agttctatca cccaggctcc agtgcagtgg tgtgatctcg gctcactgca     2640

atctccacct cccaggctca agtcatcatc ccacctcagc ctcccaagta gctgggacta     2700

caggcatgca ccaccatgcc aggctaattt ttgtattttt tatagagaca gggtttcacc     2760

atgttggcca ggctggtctc gaactcatga gctcaagtga tccactcacc ttggcctctc     2820

agagtgctgg aattacaggt gtgtgtcact atgcctagcc aaaaaaaatt tttttaatta     2880

aaaaaaaaaa ggccggctgt agtggctcac acctgtaatc cagaactttg ggagtttgag     2940

gtgggcagat caccggnggt caggagttca agaccagtct ggccaacatg gtgaaacccg     3000

gtctctacta aaaatacaaa aattagccag gtgtgggggt gcagtcctgt acttccagct     3060

actcaggagg ctgaggcagg agactcgctt gaacctggga ggcaaaggct gcagtgagct     3120

gagattgcac cactgcactc cagcctgggt gacagagcaa gacttcatct caaaaaaaaa     3180

aaaaaagctg canatttatt attattatta ttagtttatt tatttatttt tttgagacag     3240

agtctcgttc tgtcgcccag gctggagtgc ggtggcgtga tcttggctca ttgcaacctc     3300

cacctcccgg gttcaagtga ttctcctgcc tcagcctccc gagtagctgg gactacaggc     3360

gtatgccacc atgcctggct aattttttgt acttttagta gagacagagt ttcacggtgt     3420

tagccaggct ggtcttgatc tcctgacctc gtgatttacc ctccttggcc tcccaaagtg     3480

ctgggattac aggcgtgagt cactgtgccc ggcccagaat catttttttc tacttttttt     3540

tttttgaggc aaactctcga tctgttgccc aggctggagt gcagtgggca tgatcttggc     3600

tcactgcaag ctctgcctcc caggttcaag caattctcct gcctcagcct cctgagtagc     3660

tgggactaca ggcgtgtgcc accatgcccg gctaatttgc gtatttttag tagagaccgg     3720

ttttcatcat attggccagg ctggtcttga actcctgacc tcaagtgatt ctcccacctt     3780

agcctcccaa agtgctggga ttacaggcat gagctactgc acttggcctt ttctcctggt     3840

tttaaaacta ttatatgctc attacaaaat atttggtcaa tgaagaaaag aatatggaag     3900

aaaatcaaat gcatgcatac ttctatcact cagagatatc ctctgctaac attttgattg     3960

attttcttcc aatctttttt tttttttttc tttttgagac agggtctcac tctgctgccc     4020

aggctggagt acagtggcat gaccacaaca catcacagcc tcaagtgatc ttcccacttc     4080

agccttccca gtagctggga ctacaggtgc acgccaccat gttcacctaa ttttttactt     4140

tttgtagaga tgagacttca ccatgttgct caggctggtc ttgaattcct aggctcaagt     4200

gatcttcccg ctttggcctc ccaaagtgct gggattatag gtatgagcca ctgcatgtgg     4260

cctattttct tccactgttg ttcggcgtgg agaatattat atacataatt acgtaaatga     4320

tatcatactg tatatacctt ttttcctact ccttccttaa gttatatcat aatgagacta     4380

ccaattatta gacttttttt cttttttttg agacggagtc tcggtctgtc acctaggctg     4440

gagtgcaatg gcgcgatctc agctcgctgc aacctctgcc tcccaggttc aagcaattct     4500

gcctcagcct cccgagtagc tgggactaca gacacgtgcc accatgccca gctaactttt     4560

ttattttttt attagagaca gggttccacc atgctagcag gatggtctca atctctcgac     4620

ttcgtgatca gcccggcttg gcctcccaaa gtgctgggag tacaggtgtg agccaccgca     4680

ctcggcctag actaactatt taaagtaatc tggcaatgtt taacgaatac aaaactctaa     4740

aacccttgga cctaataata gctattttgg aaagtctact tgacagaaat aaaattgtga     4800

atattctttt ttgttgtttt tttgagacag agtctcattt ggacgcctag gctggagtgc     4860

agtggcatga tctcggctaa ctgcaacctc cacctcctgg gttcaagtga ttctcctgcc     4920

tcagcctcct gagcagctgg gattacaggt gtgcaccacc atgtctggct aatttttgca     4980

tttttagtag atggggtttc accatgttga ccagggtggt ctggaacttc taccctcaag     5040

tgatctaccc accttggcct cccaaagtgc tgggattaca ggtgtgagcc accacgcctg     5100

accagtgaac acttaataat atctatggaa aggtgttatt ataagaattg cttgtggggc     5160

cgggcgtggt ggctcacgcc tgtaatccca gcactttggg aggctgtggc aggcggatca     5220

cgaggtcagg agatcaagat catcctggct aacacggtga aaccccgtct ctactaaaaa     5280

taccaaaaaa ttagccaggc gtggtggcgg gcacttgtaa tcccagctat ccaggaggct     5340

gaggcaggag aattgcgtga acccaggagg cggaggtcgc agtgagctga gaccgtgcca     5400

ttgcactcca gcctgagtga cagagtgaga ctccatcaca aaaaataaat aaataaataa     5460

ataaaatata aataagtaaa taaaggtcag gagtggtggc tcacgcctgt aatcccagca     5520

ctttgggagg ccgaggtgga cagatcatga ggtcatgaga tcaagaccat cctggctaac     5580

acagtgaaac cctgcctcta ctaaaaatac aaaaagtcat ccaggtgtgg tggcacacac     5640

ctatagtccc agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggcaga     5700

ggttgcagtg agctgagatc gcgccactac actccagcct aggcgacaga gcaagactct     5760

gtctcaaaat aaataaataa ataaataaat aaataaataa ataaataaaa taaaaagcac     5820

acacacacac acacacacac acacacaatg caaaagaccc accctactac aactaacatt     5880

atatttaatg gtgaaaaact gaattctttc tccctaagtg caggaataag acaaagatgt     5940

ctgctcttac tactcttatt caacataata ctgcaatccc ttgccagtgc aataaggcaa     6000

gaaaaatgaa ataaaaggaa aactgatcag aaagaaagaa ataaaactgt tcctatttgt     6060

ggatgacatg attacataga aaatctcaaa gaatctgtaa gaaacttctt agaattaata     6120

aatgaattca tcaaggttgc agaatataag ataaacataa aaaatctatt gtatttctat     6180

atattagcaa ggaacatgtg tacacagaaa ttaaaactac aataccattt ataattgctc     6240

aaaaaggcca ggcatggtgg ctcacacctg taattcctgc actttgggag gccaaggtgg     6300

gaagattgct taagcccagg agttcaagac cagcccgggc aacatagtga gaccttgtct     6360

ctacaaaaag taaaaaatta gctgagcatg gccgggtgca gtggctcact cctgtaaccc     6420

caacactttg ggaggctgag gcgggcggat catgaggtca ggagatcgag accatcctgg     6480

ctaacacggt gaaaccctgt ctctactaaa aacacaaaaa attagctgga tgtggtggca     6540

ggcgcctgta gacccagcta ctcgggaagc tgaggcagga gaatggcgtg aacctgggag     6600

gcggagcttg cagtgagctg agattgtgcc actgcactcc agcctgggtg acacagtgag     6660

actacgtctc aaaaaaaaaa aaaaaaaaat tagctgagca ttatggtgta tgcctgtagt     6720

cccagctact ggggaggctg aggtgggagg attgcttgag ccctaggagg gcaaggctgc     6780

agtgagccat gatcacacca ctgctttcca gcctcggtag gagagcaaga ccctatctca     6840

aaaaaaaaaa aaaaaaaaaa agaaaagaaa agaaaagaaa agaaaaagaa agagagaaag     6900

aaatacttag gtgtaaatct aaaaaacatg cgtagggcca ggtgcagtgg ctcatgcctg     6960

taatcccagc actttgggaa gttgaggctg gcggatcact tgaagtcggg agtttgagac     7020

cagcctggcc aacatggtga aaccccgtct ctactaaaaa tgcaaaaatt aggcaggtgt     7080

tgtggcgcat gcctgatccc agctactttg gaggctgagg caggagaatt gcttcaaccc     7140

gggaggcaga ggttgcagtg agccaagact gttccactgc actccagcct gggcaacaga     7200

gtaagagtct gtctcccgaa aaaaaaaaaa agaaaaaaga aagcattgaa ttgtatgcta     7260

aaaactacac gatgctgatt aaagaagtca aagaagatct aaatatatgg agagacatgc     7320

tgtactcatg gattgatgga ttggaagact caacataaga cagatatcaa ttttccccaa     7380

attaatatac aagtttaatc caattcctat aaaaatacca gcaagatttt ttgtagatat     7440

aaacaagttg gccaggtgta gtggcttaca cctgtaatcc tagcactttg ggaggctgag     7500

gtgggaagat cgcttgagcc caggtgttca cgactgcagt gagctatgat tgtgtcactg     7560

cattccagct ggcactccag cctaagtgac aaagggagac cctgtctcaa aaacaaaaac     7620

aaaaccaaaa taattttgct ctgcaaaatc cctattaaga agaagaaaag aggctgggca     7680

cagtggctca ccgctgtaat cccagcacgt tgggaggctg aggcaggctg atcacttcag     7740

cccagaagtt tgagatcagc ctgggcaaca tgaggaaacc ccgtctctac caaaaaaaaa     7800

aaaaggtaca tacacacaca cacacacaca cacacacata cacaagtata tacacatata     7860

tatacacata caggtgaata gatgtatata catctattta ttgtgaatat acatctatac     7920

acacacgtgt gtgtacacat atatttaaaa tttattttta tttatttatt tatttttgag     7980

acagagtctt gctctgtcac ccaggctggg tgcacctgta ttcccaacga cacaggaggc     8040

tgaggtggga gaatcactga gccagggagg cagaggttgc agtgagccaa gatgttgcct     8100

ggttgcctgg gcaacagagc gagaccctat atcaaaaaag aagaataata agaaaagaca     8160

gtttacagaa tataagaaaa tatattcaca atccacatac ttagcaaagg actggtatct     8220

agaatatgat aaacaactct caaaactcaa aaccaaaaaa atgaacaatt caattagaaa     8280

acaggccgaa aaggacatac agttggcaaa taagcacatg aaaagttgtt caacatcatt     8340

aatcattagg gatatgtaca ttaaaaccac aataggctat cactaaacct atcagaatgg     8400

ctaaatacaa aattggaaca ccaccaaatg ctgatgagga tgtggagaaa ctgggtcatt     8460

cttccaatat tggtgggagg ctaaaatggc aaagccactc tggaaaacag tttgatagtt     8520

tcttataaaa caaaacatgc ggccgggcgc ggtagctcac gcctgtaatc ccagcacttt     8580

gggaggccga ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg     8640

tgaaaccctg tctctactaa aaatacaaaa aattagccgg gcgtggtggc gggcgcctgt     8700

agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccggga ggcggagctt     8760

gcagtgagcc gagatcgcgc cattgcactc caacctggga gacggaggga gactccgtct     8820

caaaaaaaca aaaacaaaca aacaaaaaac atgcaacaat ccagcaatat tgcaccccta     8880

ggcatttatc ctagagcaat gaagacttat gcccacacaa aaagctgcac acaaatgttc     8940

atagcagctt tattcatggt agccaacaat tagaaacaat ctagatgtcc ttcaactggt     9000

gaatgattac atccatacca cgaaatactt ttcagcaata aaaaggatga atcatagtac     9060

acaccacaac ctggatgaat ctccagggaa ttatgctgag tgaaaaaaag ccaatctcaa     9120

aaggtaatat actgtattaa tccatttata taacattctt aaaataacta attatagaaa     9180

tggagaacag atgagtgatt gccaggggtt aaggggctca gggatgggga ggggaagggg     9240

tatggctaca aaaagcaaca accttatggc gccggaaatg ttctgtattc tgattgtgtc     9300

aatgtgagca tactggttga gatatagtgc tacagttttg caagttatta ccatcagagt     9360

aaactggata gagggcacat aggatttctc tgtattactt cttacaactg caagtgaatc     9420

tacaattatc tcaaaataat aagtttagtt taatgctagg cgtggtggct cacatctgta     9480

atctcagctc tttgggaggc tgagacgggt ggatggcttg agtccaggag ttcgagacca     9540

gcctggccaa catggcaaaa ccggtctcta ctaaaaatac aaaaattagc tgggcgtggt     9600

ggcaagtgcc tgtagtccca gctactcggg aggctgaggc aggagaattg cttgaacccg     9660

ggaggtggag gttgcagtga gccgagatca cgccactaca ctgtagcttg ggcgacagag     9720

tgaggctctt tctcaaaaaa aaaaaaaaaa aaaaaaaagc aggcaggcag ggccaggaaa     9780

gcgtataatt tttgtagttc aaatgactaa cctaaaaagt gaagattggc caggcgcagt     9840

ggctcacgcc tgtaatccca gcactttggg aggccaaggc gggtggatca cgaggtcagg     9900

agattgagcc actctggcta acacagtgaa accccgtctc tactaaaata caaaaaatta     9960

gctgggcgtg gtggcacccg cctgtagttg cagctacttg ggaggctgag gcaggagaat    10020

cacttgaacc caggaggcga agttgcagcg agccgagatc acactactgc actccagcct    10080

gggtgacaaa gtgagattct gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagtg    10140

aagtttacct ttttttttaa atttttcttc ttttccttcc ctactttgtg agataatttt    10200

cttcttttta aaaagccaag agcttacttc tgtaagtaaa gattatctta agacaactta    10260

gaaatgtata ttattagtat tttctatttc attgtaagtt atttgtaaat attggttttg    10320

gtgctaacct agaattccat caaattaatt gtcccctaat atatggccat tatcattttg    10380

tctaacattg tatcctatta acaatgctgt aagtattatt tttgtagcta aattatggtt    10440

tgcattttaa aattattgtt ttaaggataa agttccagaa atgaaattaa ggatatgaac    10500

tttttgagca catcttgtca gcactgagta gtattattta aaacttttgg ggggggcaat    10560

tttataattg aaaaatatat cattgtttta atttgcattt ctttcactgc ctatgagatt    10620

aaaacaatgc actactttcc aaaaattctt aagtcttttg tgttgatgct tttgttctgt    10680

ttctatggat ctcatcttcc ttcagaacag ctccccttcc caacttcctg atttctaaca    10740

ataacagtat caccctcctt gttctcccaa tttctgaaac acagagtcat gtttttttct    10800

ctgcttcaat ccctggtttc ctatcgtcat caattatgac ctttccttgc tttgaaagtg    10860

ttttgggccg ggcatgatgt ctgccaccta ttgtaatcct agcactttgg gaggctgagg    10920

cggctggatg acttgacctg aggatttcga gaccagcctg ggcaacaggg cgaaacctcg    10980

tctctacaaa aaatacaaaa gttagtcggg agtggtggca catgcttgta gtcccagtta    11040

cttggggggc tgaggtggca ggatctcttg agcccacgag gtagatgttg cagtgagccg    11100

tgattgcgcc actgcacccc agcctaggtg acagagtgag accctgtctc aaaaaaaaaa    11160

aaatgttcta gtttcttcct cttctttgtt cccatgggaa tgccaccatc accagccaag    11220

gctcacatac ctcccacctg gattacagtg agcttccagg taatttggtc tgctactagt    11280

ctcgcctact tggatttccc ttccccctgc tgcagcattg ccttccaaag ccatgctttg    11340

cacatgccac atcctagccc attagactaa gcctagaagc ctctgcagga cgttcaccct    11400

ctcagcgcca ctgctcagtt tcccagtgga aacctctgca cccaggaggt ttccccacag    11460

cttgcctgtg ctgcctctct ggagcttttc tcccttcctg taatgtcctt gctgctcccc    11520

gtctctagtc cattgcctat acctcttttt tttttttttt ttgagatgga gtctctctct    11580

ctcatccagg ctggagtgca gtggcgcgat ctcggctcac tgcaaccttt gtctcctggg    11640

ttcaagggat tctcctgcct cagcctcccg agtaactggg attacaggcg tgcaccacca    11700

ttcctggcta atttttgtat ttttagtaaa gactgggttt caccatgttg gccaggctgg    11760

tcttgaactc ctgccctcag gtgatccacc tgcctcggcc tcccagagtg ctgggattac    11820

aggcgtgagc caccgcacct gccacaggcc catacctctt ttaagtcttc attcaatacc    11880

agttgtccca tgaatttgtc ccagactcac tcatatgctt agacctttca tattatcttg    11940

ccatagcttt ttcaaagtat gggacagcat ggacaagcag gccatggttt tcttttgaag    12000

agaagcaagg aggcagagtt attttaggag gagggttata catttcattt tgaaccaatt    12060

gcgtttgggg tgatggcagg atattaacat aaacttattt cttggaccat tggaaatgtg    12120

tgcctagaac tgaggagaga ggtcagggct ggcagtaaca acttggccac aatctgcaga    12180

gctgactggg gatgaggtgg aatttagaat gtctgtagaa acggggaaga gaaccaaaga    12240

cagagtctgg gacaacacct aaatgtagat gtcagagcaa gagttcaaga cgaagaaaaa    12300

cgaatcatac ttagaaatgg aggggaggaa caaaagaggc ggagcaaagt ggggcagaac    12360

cagagtaggc cacgctttta agaagtttgg taaaggaact gtgaaaggaa tgtagttgaa    12420

tttcagggta agctggggaa ttaaagcagt gtgtagatcc agggcaaaca gcaagtaggg    12480

caggaaccac tgaaggaaca aataaagggg gaggttgggt ccaggttgtc ttgagtaggg    12540

aagttttttt aaaaagtgtg aaactgaagg tgtggggtgg attgggtgcc tgccgtgctc    12600

tgaggaagct tggggcaact gtgtgctgag gctgtgaggt tgtctggaag gggctcctgg    12660

acagtaagag ctgagcagtg gggaagagga ctgtgtggtc tggaagagga gagaaaggag    12720

agtgagtgac tgaactggta tccaggctcc cacaccaagg cagaaagagg gagaggacct    12780

gggcatctca gggaggcaga ggcagtacca agcagggtga gaggctttag tcttagccac    12840

ctttgcccca ttcctccaaa tatacattct aagtaaaaac aaaacaaaac agaactgttt    12900

gctatgtaaa tttagcttct aaagccctgt tctacagaga ttttggagct tccactgcac    12960

ccagaaaatg cacagctaaa gagaaaactt cccttggtga tggttattag attttacaag    13020

aagaggccaa aggagacaca tacttatgcc agaagaactt tccagagata gcattgcata    13080

gcgaaatagc ctgaattatt tttatttttt aaaacatttt ttcttttctt ttttcttttc    13140

tttttctttt tttttttttt tttttgagac agagtctcac tctgtcaccc aggctggagt    13200

gcagtggcgt gatcttggct cactgcaatc tccacctccc gggttcaagc cattctcctc    13260

cctcagcctc ccaagtagct gggattacag gcatgcgtca ctatgctctg gctaattttt    13320

tttttctttt tttttttggt atttttagta gagatggggt ttcaccatgt tggccaggct    13380

ggtcttgaac tcctgacctc aagtgatcca ccgccttggc ctcccaaagt gctgggattt    13440

caggcgtgag ccaccgcacc cggccaaaaa tttcttttct ttaagatgag gcctcactct    13500

gttgcccagg ctggagtgca gtgttacaat catagctcac tgtaactttg aactcctggg    13560

ctcaagtgat cctcctgctt cagcctctca agtagctggg attacaggca tgtgccacca    13620

cacccagcta atttttttta aaataatttt ttttagagac gagggtctcg attggctgcc    13680

taggttggtc ccagactcct gacgggctgc attttaatcc tagctccacc acttacggga    13740

gtcaaaattc aaaagataga aaagggcata taggctgggt gcagtggctc acacctgcaa    13800

tcccagcaat ttgggaggct gaggtgggcg ggttgcttga ggtcaggagt tcgagatcag    13860

cctgggcaac atggcaaaac ttgtatctac taaaaataca aaaattagcc agatgtggtg    13920

gtgtacacct gtaatcccag ctactccgaa ggctgaggca agagaatccc ttgaactcag    13980

gaggcagagg ttacaatgag cagagatcga acactcgact ccataaaaac aaacaaacaa    14040

aaaaagaaag caggctgggt gtggtggctc acgcctgtaa ccccagcact tcgggaggcc    14100

aaggcgagcg gatcacctga ggttgggcat tcgagaccag cctgaccaac aaggagaaac    14160

cctgtctcta ctgaaaatac aaaattagcc gggcttggtt gcgcatgcct gtaatctcag    14220

ctactcggga ggcagaggca agataattgc ttgaacccgg gaggcggagg ttgcggtgag    14280

ccaagatcat gccattgcac tccaacctgg gcaacaatag cgaaactcca tctcaaaaaa    14340

aaaaaagcaa agggcatata gtgaaaagct ttcttcctac acatgagtat tcacttcctc    14400

ttcctagagg caaccaaggt tatttttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg    14460

tgttttggga cagtctcact ctctcaccaa ggctggaatg cagtggtgcg atctcactgc    14520

aaactctgcc tcccagtctc aagcgatctt gtgcctcagc ctcccagttt ttttttcttt    14580

taaatggggt ctcattctgt cgcccagggt ggagtgcagt ggcatgatca tagctcactg    14640

cagcctcgac ctcctgggtc aggttatcct cccacctcag cctccggcat agctggggct    14700

actggcatgc accaccacac tcagttaatt ttttttcttt tttgagacag agtctcactc    14760

tgtcacctag actggagtgc agtggtgcca tctcatttgt ttcactgcaa cctttgactt    14820

ctgggctcaa gtgattctcc cacctcagcc tcccaaggcg gctaattaaa aaaaattttt    14880

tttttttttt ttttagagat ggggtttcgc catgttgccc aggctgatct cgaactcctg    14940

ggcacaaaca atctttccac ctcgatcttt caaagagctg ggatgagaga tttccaccat    15000

gcctggcctc attttctttt ttaatttttt tttagacatt atagctcttt ttaatggcct    15060

cattttctta tgtttaattc gagaattatt cttttcatat acaaagaata tattttctcc    15120

acctttaaaa acaaatagta gactgtttaa catctcgctt tattcagtta gtgatgtttc    15180

ttagatacgg gtccaaatta gtacacaaag cacttcctca ttcctctctt acggctgcat    15240

agcagtccac tgaatgggtg agctatgatc tatttaacct attctttatt gatggacatt    15300

tggttttgta tatacatttg taattctgta tagattacaa atcaccatcc aaagaaattg    15360

tactggttta ttctcctaca atgtgtgaga gttgggtaat tacttaatct caatatgtga    15420

gagtttaggc agttacctaa tctctctgag tctcagtttc tctatctgca aaataaacaa    15480

aacagtgttg acagtatcta tttctcggaa ttattgtgga gattactgag atgatgcctg    15540

taaagtattt ggcatgtagg agttggtgct ctccaaataa ggatatgatt ttatttgtat    15600

ttgtgagcta ctgtcccagc caggtaaatg gatatgatga gacctccttg ccagaccggg    15660

tttctctgat tagaacgagg agcagatgtt gcaggaaatt agcaactgat atcagaagag    15720

ccgtgggcat tctcttgcca gaggtgccct gtctccaggg cgcctcagtc cccccccata    15780

tgtcttctgc tcccaggtcc atccaagctg aatgatcgcg ctgactcaag aagaagcctt    15840

tgggaccaag gaaactttcc cctgatcatc aagaatctta agatagaaga ctcagatact    15900

tacatctgtg aagtggagga ccagaaggag gaggtgcaat tgctagtgtt cggatgtgag    15960

tggggcaggt ggggatgagg atacctcctg cctggttccc ttccccacta ctcccacccc    16020

tgcaccaaat ccagcctgag ctggtgatac cgcagcagcc ccaagaggac caggctgtca    16080

aactggcctc caaatgtctt aaaacccttc ttgatcaggt gagggatgct ggtgggcgga    16140

ggagggaaga ggccttggga aaaggaaaga aaagggaagg aggcaaggga aggagggaga    16200

gagactgggg aagagaggat gaggggagag gaggaaagaa gagagagagg aggggagagg    16260

gaaaccctat cttggctggg ggtgcgcagc tgggtgctgg gaggaaggag atgttgggac    16320

ggcgataatg gagagatgtt gttggtttcc tgttgtctgc ccttctcctt ggggatggta    16380

tgtgtgtgac acagctggcc tttccctcca cagtgactgc caactctgac acccacctgc    16440

ttcaggggca gagcctgacc ctgaccttgg agagcccccc tggtagtagc ccctcagtgc    16500

aatgtaggag tccaaggggt aaaaacatac agggggggaa gaccctctcc gtgtctcagc    16560

tggagctcca ggatagtggc acctggacat gcactgtctt gcagaaccag aagaaggtgg    16620

agttcaaaat agacatcgtg gtgctaggta agggaagccc ctcttcgcgc agtctcctcc    16680

ctgccccagg ggctgacagc ccctccctct gctctgactg ccctgtttct ggttctggtg    16740

ctgggaggtc aggagtggag aagactaggt cccctagagc tgaggcctgt cttgaaggac    16800

tcactggggc cctcatcctc agggggctga ttggcagcca cccctcagtg tggtggacat    16860

ggagaaagga aaggctgggg aaggtaagga tgctagaggc ccgagtctcc tttggaggcc    16920

ccaaaggagg aatgtcaggg agcttacttt ctttgttgcc tcagctccac acccctacca    16980

agttggcaaa tccacttact cagggacact aacaccagta agccaaccct gatgatgttc    17040

tatgttgtac ctctggacct ctaagccagg ccactgtggg gagaccaagg tcctacccca    17100

gatcctgtcc cctgggtgct tatgtgactt aaggtagaca taaggtagtg tgccagttta    17160

gtgcatgtac gctgattgaa atcctggttc tgccacaacc atgtgacctt gggtgagtta    17220

ctaaacctct ctgcaccttg gtttcagcct ctgtgaaatg gggatgatgt taactgccat    17280

agtgactacc tcgtattaag ttgaggactg atatacgtaa ggcactgaaa atggtgcctg    17340

gcacagagta agccctagtt aagtgttcgc tgttattttg tgaagggtga tgaatacgcc    17400

tctaaggagt ggaggccaaa tggcttctgt ggtccaggaa tcctaaggac agcaaggatc    17460

ccctgtggct gggctgctct gtgatggctt ccgggaggag ggaggtggcc tgctgtagga    17520

aaatgctggg tggaagaagg gagagaaggc tggagaggta ggaaggaact gaagtatctg    17580

aagtgacaag gtgggtgtct ggactcgtcg ggtccccttc catctccctg ctgcctccac    17640

atgccaaccc cactcgtgca ccctcatctt cctatctcct cacccagggt ctctcccttc    17700

ccacctccag ctttccagaa ggcctccagc atagtctata agaaagaggg ggaacaggtg    17760

gagttctcct tcccactcgc ctttacagtt gaaaagctga cgggcagtgg cgagctgtgg    17820

tggcaggcgg agagggcttc ctcctccaag tcttggatca cctttgacct gaagaacaag    17880

gaagtgtctg taaaacgggt tacccaggac cctaagctcc agatgggcaa gaagctcccg    17940

ctccacctca ccctgcccca ggccttgcct cagtatgctg gctctggaaa cctcaccctg    18000

gcccttgaag cgaaaacagg aaagttgcat caggaagtga acctggtggt gatgagaggt    18060

gaggggccag gccagggagg ggtgggcagg ggaaggagtt ggaggggcct ggcccagggc    18120

tccctctgag gcaagccagg ccccaagagg ggatgcctag gccctggtca cctggatgaa    18180

gtgagggagg gccctctggg tttggggctg gttttgaact gagacatcca tgagccagcc    18240

tggggctggc ttcactgaag atc                                            18263


<210>  78
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Met Cys Arg Ala Ile Ser Leu Arg Arg Leu Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Leu Ser Gln Leu Leu Ala Val Thr Gln Gly Lys Lys Val Val Leu Gly 
            20                  25                  30          


Lys Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys 
        35                  40                  45              


Ser Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly 
    50                  55                  60                  


Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg 
65                  70                  75                  80  


Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile 
                85                  90                  95      


Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val 
            100                 105                 110         


Glu Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala 
        115                 120                 125             


Asn Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu 
    130                 135                 140                 


Glu Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg 
145                 150                 155                 160 


Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu 
                165                 170                 175     


Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys 
            180                 185                 190         


Lys Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala 
        195                 200                 205             


Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe 
    210                 215                 220                 


Pro Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp 
225                 230                 235                 240 


Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp 
                245                 250                 255     


Leu Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys 
            260                 265                 270         


Leu Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala 
        275                 280                 285             


Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala 
    290                 295                 300                 


Lys Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Val 
305                 310                 315                 320 


Ala Gln Leu Asn Asn Thr Leu Thr Cys Glu Val Met Gly Pro Thr Ser 
                325                 330                 335     


Pro Lys Met Arg Leu Thr Leu Lys Gln Glu Asn Gln Glu Ala Arg Val 
            340                 345                 350         


Ser Glu Glu Gln Lys Val Val Gln Val Val Ala Pro Glu Thr Gly Leu 
        355                 360                 365             


Trp Gln Cys Leu Leu Ser Glu Gly Asp Lys Val Lys Met Asp Ser Arg 
    370                 375                 380                 


Ile Gln Val Leu Ser Arg Gly Val Asn Gln Thr Val Phe Leu Ala Cys 
385                 390                 395                 400 


Val Leu Gly Gly Ser Phe Gly Phe Leu Gly Phe Leu Gly Leu Cys Ile 
                405                 410                 415     


Leu Cys Cys Val Arg Cys Arg His Gln Gln Arg Gln Ala Ala Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Met Gln Lys Ser His Asn Leu Ile 
    450                 455             


<210>  79
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg 
    290             


<210>  80
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80
tgtttgcctg tgacatgaac tcattgtgac acaaaccact gtgctagggg ggatccacta       60

gtaacggccg ccagtgtgct ggaattcgcc ctcgcaaggg ccaggcatat aagtacacaa      120

taaacaaatg gcagctctct cc                                               142


<210>  81
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81
cccctccttc cttccccagg cactttccaa gtgtcaactc tagagcctat cgcggccgca       60

ccggtataac ttcgtataat gtatgctata cgaagttat                              99


<210>  82
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82
ataacttcgt ataatgtatg ctatacgaag ttatgtcgac gtagcctatt tctctagatc       60

caaaatgatg acaacaaaag gtaccttgtg                                        90


<210>  83
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83

Met Gln Pro Trp Leu Trp Leu Val Phe Ser Met Lys Leu Ala Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Leu Thr Cys Ser Leu Thr Thr Leu Ser Leu Leu 
                165                 170                 175     


Val Val Cys Ile Leu Leu Leu Leu Ala Phe Leu Gly Val Ala Val Tyr 
            180                 185                 190         


Phe Tyr Cys Val Arg Arg Arg Ala Arg Ile His Phe Met Lys Gln Phe 
        195                 200                 205             


His Lys 
    210 


<210>  84
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Val Leu His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys 
1               5                   10                  15      


Val Gln Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser 
            20                  25                  30          


Leu Ser Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser 
        35                  40                  45              


Ser Asp Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly 
    50                  55                  60                  


Thr Ile His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg 
65                  70                  75                  80  


Asp Ala Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp 
                85                  90                  95      


Ser Gly Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe 
            100                 105                 110         


Gly Lys Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala 
        115                 120                 125             


Gln Pro Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro 
    130                 135                 140                 


Arg Pro Glu Thr Gln Lys Gly 
145                 150     


<210>  85
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85
tgaacctgct gctgctgggt gagtcgatta tcctggggag tggagaagct aggccgagcc       60

agttccgggt gtcgccgctg gatcggacct ggaacctggg                            100


<210>  86
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86
atgccaggga cagccctgat actgtaggta gagtcaaggg ctgtccaagt accggtataa       60

cttcgtataa ggtatcctat acgaagttat                                        90


<210>  87
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87
ataacttcgt ataaggtatc ctatacgaag ttatctcgac ctgatcttgg agggagacct       60

ggaccgggag acgtgctggg ggcagggtt                                         89


<210>  88
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Arg Pro Ser Gln Phe 
            20                  25                  30          


Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr Val Glu 
        35                  40                  45              


Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys Ser Trp 
    50                  55                  60                  


Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr Gln Arg 
                85                  90                  95      


Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu Ser Asp 
            100                 105                 110         


Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu Ser Asn 
        115                 120                 125             


Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys 
    130                 135                 140                 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
        195                 200                 205             


Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys Arg Val Cys Lys 
    210                 215                 220                 


Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro Arg Pro Ser Glu 
225                 230                 235                 240 


Lys Ile Val 
            


<210>  89
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89

Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu 
1               5                   10                  15      


Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr 
            20                  25                  30          


Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro 
        35                  40                  45              


Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly 
    50                  55                  60                  


Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val 
65                  70                  75                  80  


Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys 
                85                  90                  95      


Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
            100                 105                 110         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        115                 120                 125             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    130                 135                 140                 


Cys Arg Pro Ala Ala Gly Gly Ala 
145                 150         


<210>  90
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of the chimeric human/mouse MHC I locus at the 5' 
       junction of mouse/human sequences

<400>  90
agtgtcgccg cggacgctgg atataaagtc cacgcagccc gcagaactca gaagtcgcga       60

atcgccgaca ggtgcgatgg ccgtcatggc gccccgaacc ctcgtcctgc tactctcggg      120

ggctctggcc ctgacccaga cctgggcgg                                        149


<210>  91
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of the chimeric human/mouse MHC I locus at the 3' 
       junction of human/mouse sequences

<400>  91
ggtggtgcct tctggacagg agcagagata cacctgccat gtgcagcatg agggtttgcc       60

caagcccctc accctgagat ggggtaagga gagtgtgggt gcagagctgg ggtcagggaa      120

agctggagct ttctgcagac cctgagctgc tcagggctg                             159


<210>  92
<211>  120
<212>  DNA
<213>  Mus musculus

<400>  92
aactcccccc cagaggagca gcttatctgg tggtttcttc cagccctcaa ggggtagacc       60

tatgggaggg tccttttttg tataaagctg taacattgtg gaaaccttgc gctcgttcgc      120


<210>  93
<211>  120
<212>  DNA
<213>  Mus musculus

<400>  93
actgaagaca gtagcccaaa gaatagtaaa aagaagagca agaagactca aagccctgaa       60

gaaaggcatt ctgtgtccag aacacgaaaa caaacccaga attatttgcc gactaccttg      120


<210>  94
<211>  120
<212>  DNA
<213>  Mus musculus

<400>  94
agacaaacct ctctgccacc tggtctccct gcccctgccc aggctctggg gtaggcacct       60

gtggggaaga aacttttttg tatcacgatg taacattgtg gaaaccttgc gctcgttcgc      120


<210>  95
<211>  120
<212>  DNA
<213>  Mus musculus

<400>  95
aacctacctt gtcctggctt gcgagagagc gaacaacgtt tggcacccaa tcccttttca       60

tcccgctccc ccagaaaggg tgaagttgag agctgtctcc attatttgcc gactaccttg      120


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  97

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  98
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRAC sgRNA

<400>  98
gcugguacac ggcaggguca                                                   20


<210>  99
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRBC1/2 sgRNA

<400>  99
ugggaaggag gugcacagug                                                   20


<210>  100
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  100
tcaaagtcgg tgaacaggca gag                                               23


<210>  101
<211>  25
<212>  DNA
<213>  Mus musculus

<400>  101
gaccttgggt ggagtcacat ttctc                                             25


<210>  102
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  102

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC EARS:306-313 PEPTIDE

<400>  103

Ser Leu Leu Asp Ile Ile Thr Asn Cys 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC MAGEH1:90-98 PEPTIDE

<400>  104

Ser Leu Leu Met Ser Ile Leu Ala Leu 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC FBXL22:4-12 PEPTIDE

<400>  105

Leu Leu Thr Met His Ile Thr Gln Leu 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC URB1:1853-1861 PEPTIDE

<400>  106

Ser Leu Leu Thr Trp Ile Leu His Ile 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC LV9-5, mucin peptide

<400>  107

Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   


