                               SEQUENCE LISTING

<110> BIOGEN MA INC.
 
<120> NUCLEIC ACID DELIVERY TO THE CENTRAL NERVOUS SYSTEM

<130> 13751-0301WO1

<140>
<141>

<150> 63/169,539
<151> 2021-04-01

<160> 3     

<170> PatentIn version 3.5

<210> 1
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (5)..(6)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (8)..(9)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (9)..(10)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (10)..(11)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (11)..(12)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (12)..(13)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (13)..(14)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-(2-methoxyethyl) guanine

<220>
<221> misc_feature
<222> (14)..(15)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (15)..(16)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (16)..(17)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-(2-methoxyethyl) guanine

<220>
<221> misc_feature
<222> (17)..(18)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-(2-methoxyethyl) guanine 

<400> 1
ucacuuucau aaugcugg                                                     18


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-(2-methoxyethyl) guanine

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="Phosphodiester internucleoside linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="Phosphodiester internucleoside linkage"

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="Phosphodiester internucleoside linkage"

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-(2-methoxyethyl) guanine

<220>
<221> misc_feature
<222> (5)..(6)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methyl-cytosine

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (8)..(9)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (9)..(10)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (10)..(11)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (11)..(12)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (12)..(13)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (13)..(14)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (14)..(15)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> misc_feature
<222> (15)..(16)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (16)..(17)
<223> /note="Phosphodiester internucleoside linkage"

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (17)..(18)
<223> /note="Phosphodiester internucleoside linkage"

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (18)..(19)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (19)..(20)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-(2-methoxyethyl) adenine

<400> 2
gccaggctgg ttatgacuca                                                   20


<210> 3
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-(2-methoxyethyl) guanine

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (2)..(3)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (3)..(4)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (4)..(5)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (5)..(6)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (6)..(7)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (7)..(8)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (8)..(9)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (9)..(10)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (10)..(11)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-(2-methoxyethyl) 5-methyl-uracil

<220>
<221> misc_feature
<222> (11)..(12)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (12)..(13)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (13)..(14)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (14)..(15)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (15)..(16)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-(2-methoxyethyl) 5-methyl-cytosine

<220>
<221> misc_feature
<222> (16)..(17)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-(2-methoxyethyl) adenine

<220>
<221> misc_feature
<222> (17)..(18)
<223> /note="Phosphorothioate internucleoside linkage"

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-(2-methoxyethyl) guanine

<400> 3
gcuauuaccu uaacccag                                                     18


