                         SEQUENCE LISTING

<110>  Protagonist Therapeutics, Inc.
 
<120>  CONJUGATED HEPCIDIN MIMETICS

<130>  PRTH-063/01WO 321085-2518

<140>  PCT/US2022/022809
<141>  2022-03-31

<150>  US 63/169,527
<151>  2021-04-01

<150>  US 63/169,533
<151>  2021-04-01

<150>  US 63/169,538
<151>  2021-04-01

<150>  US 63/325,323
<151>  2022-03-30

<160>  323   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  1

Cys Thr His Xaa Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  2

Glu Thr Cys Xaa Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  3

Glu Thr His Cys Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  4

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  5

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D from lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  6

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys Lys 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  7

Glu Thr His Xaa Pro Cys Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  8

Glu Thr His Xaa Pro Cys Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  9

Cys Glu Thr His Xaa Pro Cys Ile Lys Xaa 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid N-terminal conjugation

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  10

Cys Glu Thr His Xaa Pro Cys Ile Lys Xaa 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  11

Xaa Glu Thr His Xaa Pro Cys Ile Lys Xaa 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  12

Xaa Glu Thr His Xaa Pro Cys Ile Lys Xaa 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  13

Xaa Glu Thr His Xaa Pro Cys Ile Lys Xaa 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  14

Xaa Glu Thr His Xaa Pro Xaa Ile Lys Xaa 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is beta-homophenylalanine

<400>  15

Xaa Glu Thr His Xaa Pro Xaa Ile Lys Xaa 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is beta-homophenylalanine

<400>  16

Xaa Val Glu Thr His Xaa Pro Xaa Ile Lys Xaa 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Aminohexanoic acid aplmityl conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is beta-homophenylalanine

<400>  17

Cys Val Glu Thr His Xaa Pro Xaa Ile Lys Xaa 
1               5                   10      


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogue


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is penicillamine

<400>  18

Glu Thr His Phe Pro Xaa Ile Lys Phe Glu Pro Arg Ser Lys Gly Xaa 
1               5                   10                  15      


Lys 
    


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogue


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<400>  19

Glu Thr His Phe Pro Xaa Ile Lys Phe Glu Pro Arg Ser Lys Gly Cys 
1               5                   10                  15      


Lys 
    


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  20

Glu Thr His Cys Pro Cys Ile Lys Xaa Lys 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  21

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  22

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  23

Glu Thr His Xaa Pro Cys Ile Lys Xaa Cys 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  24

Glu Thr His Cys Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  25

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  26

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys Lys 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  27

Glu Thr His Xaa Pro Cys Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  28

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys Lys 
1               5                   10      


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  29

Glu Thr His Cys Pro Cys Ile Lys Xaa Lys 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  30

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  31

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  32

Glu Thr His Xaa Pro Cys Ile Lys Xaa Cys 
1               5                   10  


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  33

Glu Thr His Cys Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  34

Glu Thr His Xaa Cys Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  35

<400>  35
000

<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  36

Glu Thr His Xaa Pro Cys Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  39

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  40

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  41

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  42

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  43

Cys Thr His Xaa Pro Ala Ile Cys Xaa Lys 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  44

Glu Thr His Xaa Pro Cys Xaa Lys Xaa Lys 
1               5                   10  


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  45

Glu Cys His Xaa Cys Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  46

Glu Cys His Xaa Cys Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  IsoGlu_Palm conjugation

<400>  101

Asp Thr His Phe Pro Cys Cys Ile Lys Phe Glu Pro Arg 
1               5                   10              


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  102

Xaa Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is D form penicillamine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  103

Xaa Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is D form penicillamine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  104

Cys Thr His Xaa Pro Ala Ile Xaa Xaa Lys Lys 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form cystein

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  105

Cys Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  106

Cys Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form cystein

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  107

Cys Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  108

Cys Thr His Xaa Pro Ala Ile Xaa Xaa Lys Lys 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  109

Xaa Thr His Xaa Pro Ala Ile Xaa Xaa Lys Lys 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  110

Xaa Thr His Xaa Pro Ala Ile Cys Xaa Lys Lys 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  111

Xaa Thr His Xaa Pro Ala Ile Xaa Xaa Lys Lys 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  112

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is trimethyl-L-lysine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  113

Glu Cys His Xaa Cys Xaa Xaa 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  114

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  115

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Dap_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  116

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Dap_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  117

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  118

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is N-methyl cysteine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  119

Glu Cys His Xaa Xaa Lys Xaa 
1               5           


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  120

Glu Cys His Xaa Xaa Lys Xaa 
1               5           


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_Palm conjugation

<400>  121

Glu Cys His Xaa Cys Lys 
1               5       


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  122

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  DMG_N_2ae_Palm conjugation

<400>  123

Xaa Cys His Xaa Cys Lys 
1               5       


<210>  124
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  DMG_N_2ae_Palm conjugation

<400>  124

Glu Cys His Xaa Cys Lys 
1               5       


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  125

Glu Cys His Xaa Xaa Lys Xaa 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is (2S,4R)-4-mercaptopyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  126

Glu Cys His Xaa Xaa Lys Xaa 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is (2S,4R)-4-mercaptopyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Butyl Phenylalanine

<400>  127

Glu Xaa His Xaa Xaa Lys Xaa 
1               5           


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is beta, beta-diphenylalanine

<400>  128

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is beta, beta-diphenylalanine

<400>  129

Glu Cys His Xaa Cys Lys Xaa 
1               5           


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  C terminal Hexadecane_Amine conjugation

<400>  130

Glu Cys His Xaa Cys 
1               5   


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is 12-aminododecanoic acid

<400>  131

Glu Cys His Xaa Cys Xaa 
1               5       


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  C terminal Dodecyl_Amine conjugation

<400>  132

Glu Cys His Xaa Cys 
1               5   


<210>  133
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<400>  133

Glu Cys His Xaa Cys Lys 
1               5       


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  134

Glu Cys His Xaa Pro Cys Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-(3-methoxy-3-oxopropyl)-6-methylheptanoic acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form lysine

<400>  135

Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-(3-methoxy-3-oxopropyl)-6-methylheptanoic acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is trimethyl-L-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form lysine

<400>  136

Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-(3-methoxy-3-oxopropyl)-6-methylheptanoic acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form lysine

<400>  137

Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-(3-methoxy-3-oxopropyl)-6-methylheptanoic acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form lysine

<400>  138

Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is trimethyl-L-lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  139

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is trimethyl-L-lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is D form beta, beta-diphenylalanine

<400>  140

Glu Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is trimethyl-L-lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  141

Glu Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  142

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  143

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa in N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  144

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is alpha-methylproline

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  145

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is O-methyl-L-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_C18_Diacid_OMe conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  146

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is O-methyl-L-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  147

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is N-methyl-phenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  148

Xaa Ser His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-methyl-lysine

<400>  149

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  150

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysing

<400>  151

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  152

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-methyl-lysine

<400>  153

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  154

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysing

<400>  155

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-methyl-lysine

<400>  156

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysing

<400>  157

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  158

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  159

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid_18_OMe conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  160

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid_18_OMe conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  C terminal N_Ethylamine conjugation

<400>  161

Glu Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is homo-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  CH2CH2CH2NH_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  162

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  C terminal Diphenylethylamine conjugation

<400>  163

Glu Thr His Xaa Pro Cys Cys Xaa 
1               5               


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  C terminal Diphenylethylamine conjugation

<400>  164

Glu Thr His Xaa Pro Cys Cys Xaa 
1               5               


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Diaminopropionic acid

<400>  165

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is N-methylglutamic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  166

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is N-methylglutamic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  167

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is homo-serine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  168

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  169

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  170

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  171

Glu Pro His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  172

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  173

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  174
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  174

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  175

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  176

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  177

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  178

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  179

Glu Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  180

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-methyl-phenylalanine

<400>  181

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is tert-Leucine

<400>  182

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Biphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  183

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-phenylalanine

<400>  184

Xaa Xaa His Xaa Pro Cys Cys Xaa 
1               5               


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-methyl-phenylalanine

<400>  185

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  186

Xaa Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  187
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  187

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  188

Glu Pro His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<400>  189

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-methyl-threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  190

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  191

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  192

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  193

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  194

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  195

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  196

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  197

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  198

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  199

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  200
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  200

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  201

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  202

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  203

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  204

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  205

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  206

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  207

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  208
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  208

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  209
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  209

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is tert-leucine

<400>  210

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Xaa 
1               5                   10  


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  211

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  212
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is tert-leucine

<400>  212

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Xaa 
1               5                   10  


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  213

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  214

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Biphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  215

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Biphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  216

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is (S)-morpholine-3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  217

Glu Thr His Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  218
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  218

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  219
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Carnitine_Alkyl conjugation

<400>  219

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  220

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  221
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  221

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  222

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  223
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  223

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  224
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is L-1,2,3,4-Tetrahydroisoquinoline- 3-carboxylic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  224

Glu Thr His Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  225
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is D form N-Methyl-Lysine

<400>  225

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Alpha-methylphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  226

Leu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta-homoproline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  227

Leu Thr Xaa Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  228
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is beta-homoproline

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  228

Leu Thr His Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  229
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  229

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  230
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  230

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  231
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  231

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  232
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  232

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  233
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  233

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  234
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is homo-serine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  234

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  235
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  235

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  236
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  236

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  237
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-Methyl-Lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is (S)-2-amino-3-morpholinopropanoic acid

<400>  237

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  238
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Phe(4-COOH)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  238

Leu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  239
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Nipecotic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  239

Leu Thr Xaa Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  240
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Nipecotic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  240

Leu Thr His Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  241
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  241

Leu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  242
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (S)-2-aminoadipic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  242

Xaa Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  243
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  243

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (S)-2-aminoadipic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  244

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  245
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (S)-2-aminoadipic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Xaa is Nipecotic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  245

Xaa Thr His Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  246
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (S)-2-aminoadipic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-pyridylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  246

Xaa Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  247
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is D form N-Methyl-Serine

<400>  247

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is D form N-Methyl-Glutamine

<400>  248

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is D form N-Methyl-Leucine

<400>  249

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  250
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is D form N-Methyl-Phenylalanine

<400>  250

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  251
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Glutamine

<400>  251

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  252
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Leucine

<400>  252

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  253
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  253

Glu Xaa His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  254
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  254

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  255
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PEG11_OMe conjugation

<400>  255

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  256

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is D form N-Methyl-Tyrosine

<400>  257

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  258
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is 1-Napthylalanine

<400>  258

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  259
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Tyrosine

<400>  259

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  260
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Serine

<400>  260

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  261
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is Napthylalanine

<400>  261

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  262
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Isoleucine

<400>  262

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  263
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is N-Methyl-Phenylalanine

<400>  263

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys Xaa 
1               5                   10      


<210>  264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Diaminobutyric acid

<400>  264

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  265
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is (S)-2-amino-5-morpholinopentanoic acid

<400>  265

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  266
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-methyl-phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  266

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Lys 
1               5                   10  


<210>  267
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is D form N-methyl-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acetyl conjugation

<400>  267

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  268
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Xaa is homocysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  268

Glu Thr His Xaa Pro Xaa Xaa Lys Xaa Lys 
1               5                   10  


<210>  269
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Xaa is homocysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  269

Glu Thr His Xaa Pro Xaa Xaa Xaa Xaa Lys 
1               5                   10  


<210>  270
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is homocysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  270

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Lys 
1               5                   10  


<210>  271
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  271

Glu Thr His Xaa Pro Xaa Cys Xaa Xaa Lys 
1               5                   10  


<210>  272
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  272

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Lys 
1               5                   10  


<210>  273
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  273

Glu Thr His Xaa Pro Xaa Xaa Xaa Xaa Lys 
1               5                   10  


<210>  274
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Xaa is penicillamine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  274

Glu Thr His Xaa Pro Xaa Xaa Lys Xaa Lys 
1               5                   10  


<210>  275
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-methyl-Lysine

<400>  275

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  276
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is D form N-methyl-Lysine

<400>  276

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  277
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-methyl-Lysine

<400>  277

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  278
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  278

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Lys 
1               5                   10  


<210>  279
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 1-Methyl-histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-methyl-phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  279

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  280
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 1-Methyl-histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Nipecotic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  280

Glu Thr Xaa Xaa Xaa Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  281
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-methyl-cysteine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-methyl-phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  281

Glu Thr His Xaa Pro Cys Xaa Xaa Xaa Lys 
1               5                   10  


<210>  282
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  282

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  283
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  283

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  284
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is (S)-2-amino-3-(6-methoxy-1H-indol-3-yl)propanoic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  284

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  285
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 1-Methyl-histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  285

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  286
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is (4-Trifluoromethyl)-L-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  286

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  287
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is (S)-2-amino-3-(6-methoxy-1H-indol-3-yl)propanoic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  287

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  288
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (S)-2-amino-3-(2H-tetrazol-5-yl)propanoic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  288

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  289
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  289

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  290
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is tert-leucine

<400>  290

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  291

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  292
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-Methyl-Lysine

<400>  292

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Xaa 
1               5                   10  


<210>  293
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form lysine

<400>  293

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  294
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<400>  294

Glu Thr His Xaa Pro Cys Cys Xaa 
1               5               


<210>  295
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  295

Glu Thr His Xaa Pro Cys Cys Xaa Xaa 
1               5                   


<210>  296
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is 3-Quinolinylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  296

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  297
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Biphenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  297

Glu Thr Xaa Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  298
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  4_Fluorophenylacetic_acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  298

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  299
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nicotinic_acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  299

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  300
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  isonipecotic acid  conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  300

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  301
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  301

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  302
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  302

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  303
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PEG12_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  303

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  304
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PEG12_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  304

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  305
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  305

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  306
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  306

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  307
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  307

Xaa Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  308
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is N-methyl-lysine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  308

Glu Thr His Xaa Pro Cys Cys Xaa Xaa Lys 
1               5                   10  


<210>  309
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  309

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  310
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  310

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  311
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  311

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  312
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  312

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form Lysine

<400>  313

Xaa His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   


<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form Lysine

<400>  314

Glu His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   


<210>  315
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  315

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  316
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  316

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  317
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is L-Glutamic acid gamma-methyl ester

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  317

Xaa Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  318
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized hepcidin analogues


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric Acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta, beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  DMG_N_2ae_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  318

Glu Thr His Xaa Pro Cys Cys Lys Xaa Lys 
1               5                   10  


<210>  319
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  319

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210>  320
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  320

Asp Thr His Phe Pro Ile Cys Ile Phe 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D form isoleucine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D form isoleucine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D form proline

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D form phenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D form histidine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form threonine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form aspartic acid

<400>  321

Phe Ile Cys Ile Pro Phe His Thr Asp 
1               5                   


<210>  322
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  2Peg11'-Palm conjugation

<400>  322

Asp Thr His Phe Pro Cys Ile Lys Phe Lys Pro Arg Ser Lys Gly Cys 
1               5                   10                  15      


Lys 
    


<210>  323
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  2Peg11'-Palm conjugation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Sarcosine

<400>  323

Asp Thr His Phe Pro Cys Ile Lys Phe Lys Pro Arg Ser Lys Xaa Cys 
1               5                   10                  15      


Lys 
    


