                         SEQUENCE LISTING

<110>  Peking University
 
<120>  SIRNA, MEDICAL COMPOSITIONS, AND METHODS FOR TREATING DIABETES USING THE SAME

<130>  2021/04/04

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
gguuacugua guucacaaa                                                    19


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
uuugugaacu acaguaaccu c                                                 21


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
ggacuuugau acaauguca                                                    19


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
ugacauugua ucaaagucca c                                                 21


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cauuguuucu gguuauuaa                                                    19


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
uuaauaacca gaaacaaugg c                                                 21


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gaguaaagau gaucuugaa                                                    19


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
uucaagauca ucuuuacuca a                                                 21


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
gagauuugau gguaagaaa                                                    19


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
uuucuuacca ucaaaucucc a                                                 21


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
gguuacugua guucacaaa                                                    19


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
uuugugaacu acaguaaccu c                                                 21


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
ggacuuugau acaauguca                                                    19


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ugacauugua ucaaagucca c                                                 21


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
cauuguuucu gguuauuaa                                                    19


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
uuaauaacca gaaacaaugg c                                                 21


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gaguaaagau gaucuugaa                                                    19


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
uucaagauca ucuuuacuca a                                                 21


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
gagauuugau gguaagaaa                                                    19


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
uuucuuacca ucaaaucucc a                                                 21


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
ggaccgagct gtcttctgg                                                    19


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
cacacagacc aataggaacc c                                                 21


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gtgctggtgt ggcctacag                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
attgctcggc ccaatgagg                                                    19


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
aacggcagca tttataaccc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
cgatctgcag acacacactg                                                   20


<210>  27
<211>  9865
<212>  DNA
<213>  Mus musculus

<400>  27
gcaagatgtc tatgaaacag gcttcagttt ttctgttgat acagttcata tgctatatta       60

gacctggagc ctgtgggaaa gtgctggtgt ggcctacaga atacagccat tggataaata      120

tgaaaataat cctggatgaa cttgtccaga gaggtcatga cgtcaccgtt ctcatatctt      180

ctgcttccat cctcattggg ccgagcaatg aatcttctat taattttgaa atttattctg      240

cacctttgag taaagatgat cttgaatatg cttttgaaaa atgggtagga aactggacat      300

acgaattaaa aaaacttcca ttttggacat cttattcaaa actgcaaaaa atctccagtg      360

aatattcaga catgattgaa agtttctgca aagcagtagt ttggaacaag agcctcatga      420

aaaaactcca aggatctaag tttgatgtcg ttctagcaga tgccttggtt ccctgtggtg      480

agctgctatc agaactgctt aagacacctt tagtatacag tctccgcttc tgtcctggat      540

acaaatgtga aaagtacagt gggggccttc cactcccccc ttcctatgtg cctgtggttc      600

tgtcagaact aagtgaccac atgacatttg cagaaagggt gaagaatatg ttgcaggtgt      660

tgctttttga cttttggttt caaacattta acgagaaatc ctggaatcag ttttacagtg      720

atgttctagg taaactgtgc ctttcattgt tactgtgaaa tcctgacttg atgttttttt      780

gaatgagaat gtgtataggt gaatataaag gcatagaatg agattcttaa ttgtgagctg      840

atagagtaaa aatagaagag aatcaaatag gctcttagca aggcaaaata ctgcagagta      900

attatacaga acacttcaga aattactaac catgcaaaat tagacaagga agatttctct      960

tggtgatcat ttgatctgct ctacattgtc taagtataag aaactccagg tttcattgag     1020

tgctttaata tctgtaaatg agaacactac agagtcataa ttcattacca caactatttg     1080

tgtagcactg aagaaaacac atttccttaa gacatttact cacttagaaa ttaaaacatt     1140

tatcaagaat gtcctgaaag cttattcaca attaaattgt accactagaa ccagaaacag     1200

tcaaggcaac ttgattttct tagaatttga gttggatcat atctataaaa cttaatctta     1260

aagccttaaa tcttgataga aatgcatagg tttttattat tttcaaaata ccttttcatt     1320

aaataaaata ttacctaatt tattaggaga aacagtttaa atattaactg cttatacaaa     1380

tacccagcta taactttgag atatacaact aagttagtga tactagtctc ctgtaacgga     1440

catagtacag cagggataaa agaaaattag tcattcctta ccaattatca cattgcattt     1500

caagaatcag aaaccaaaag catagctact aaaatgtgta aaatagacta aatattctac     1560

aaaagctgtg tttctaagca ttttcaagca cctttgcaag agcaaaattt caaatttatt     1620

ggtgcaacgt tggaaatcaa tgtaattttc acacaatatt tatgttaata caattatatc     1680

ataaatcata actggaacat tttaaattgc ttgtctacat gacctcaact cattgcagaa     1740

atcacatgct ttattccaga caaactcctt tcaccatagt gtatttgttt ttggttttgg     1800

ggtgcaggga gacctacaac attaactgag atgatgggga aggcagacat atggctcgtt     1860

cgaaccttct gggacttgaa atttcctcac cctttcttgc ctaattttga ctttgttgga     1920

ggactccatt gtaaaccagc caaaccactg cctaaggtaa ctctacattg tttcccttgg     1980

taaactgttt ttccttttca tggaaacaat tcttaaccac tatttccaga tgtttggttt     2040

tatgaaacat atatcaagtg gattagaact ctctgacaat taagatatac attatttcct     2100

tacatctctg aatcttctta ctcttaagca aagtattata ccactttaga atgtggtcag     2160

tgatttaaag gtgtttaggt aactcataaa agagaattta tgctctcttc aagaacatat     2220

agtaaatgcc agagacgtgt tgaacagcta aagaaataaa gaatcaatat cttcactaaa     2280

tagaaattgt attctacttg gaaacattat agtgatgaag agatgttata tacactgtga     2340

caaacgttat acattgttat attagataaa cagataagtt gaagatatat ccaacagaga     2400

tgagatgtaa tgtcctagaa tccttgtgaa gttacaatga cctagccaat gtacagggtt     2460

agattaatga atgaaaagaa gagaggaaaa atagaaaatt gaaacaacca ttgaaagaat     2520

gacagactta gataagcagg acgatgacat ggcaggcagg agtttttgga cagcttcatg     2580

tatgcatgtt ccacacatgg ctctctttta acctttccac ttccttggag tctttctacc     2640

cttaggttct gcagggattt attttttgtc tttgtagttt ccacatgcaa aagaaaacaa     2700

cacttatctt tctgtttctg gcttattgat taatctcctg tcctctaaac aatagctatt     2760

ttcctaaatt atttaataat aataacattt ttctatctga gtaaaacaca attatgtata     2820

tttaccaaca ctttgataca cattgatcac ttgaagaata tctaagctaa tcctatatag     2880

gggaattttg aataatgatg taataaacat tattatgtag atttttcact tgcaattatt     2940

tccttcagat atcaccaaag agtggcatag gttaactgta tgtaacacat taatgttatt     3000

tatatcaaga cgcttattta tgtattttat ctaattttac atttccaaat atgataaatg     3060

cataaatgtt caatttccat attatctgta ggagcatttt tatagtacat acatttttgt     3120

gacattcatg ataagtggat tatgatggaa tattgatata ttttgaattt atttttttaa     3180

tagctgacat tattgaaaga ttttcagata attgtaagct atttaaatct gagggaacaa     3240

ctactttgga tcatttgcct aagttaattg aattcttatt tcttctgatg ttagtttgtt     3300

tttttaatta gcatactctc ttaaaaattt atgaatatta cacaactctt tagagagtct     3360

cttcattttg atagattttt ttgttcttca taagctttta ctataaggta ctcctatttt     3420

tcaattccca aattactccc aatgctactg tggttattca atacattact gctttttatt     3480

ctatgtcatg gagtttctct tcttttttcc ctatttttat gtagtagaaa cacattactt     3540

ttatttagaa tgtactaaag ataatttctt ttttttcaat gtgagaatac ataatttttt     3600

caattaatta atttatttat gccccaaatg ttgcctacat cgtggtcccc ctcttagagt     3660

tcttctctat ccctcatctc cctctatctc tccttcccta catttcttct tcttttctat     3720

tccctccttt gctgctcgtc cttctcattt ctctcaaaga aaccacaaaa aagaaaatca     3780

aagaaatgaa cttaaaaaaa taagaccaaa aatattccag caaaacgaaa ggaaagaaaa     3840

agcacacata agatttaata taaataaata aataaataaa taaataaata aataaaaaca     3900

tggcatttat tttaggtggc taactattcc tgggcttggg acctcctctg gtgtatgatt     3960

gatttaccca gtcactactg gggaaagctg gttttcccct ttgttatcag ataccacttg     4020

caaatagctt cttagttaga agtggaagtc catgaacatt ttctattctg tgcgcaggaa     4080

cttcatctgc cttgaacctg ggcaggtctt agacatgctg ctacagtctc tgtgagttta     4140

tatgagcatc agtcttatta tgcctggtag accctgggat gtcattcatc ccctctggat     4200

cttataaact ttctccctcc tactcatgat ggtttgaaaa tacctcctaa tgaaactcta     4260

aatttcaata actctactga caataatttt ttactctaat tttcttatgt tggtaaattg     4320

tactatagca caaatgtact ctccatgaac acatgactgc tgaggcaatg gatacactgg     4380

tctcactaaa ataattccag taattacatt atttcctctg gtaatgtttg tctcagttcc     4440

ttagacagtg cttcccaggc agccattaat ttgtgatgtc acaactgtct tcataggaaa     4500

tggaagaatt tgttcagagc tctggagaac atggtgtggt ggtgttttct ctgggatcaa     4560

tggttaaaaa cattaaagaa gaaaaggcca atgtagttgc ttctgctctt gcccagattc     4620

cacagaaggt aacataaaga gttcactggg tggacaaatg tattgtaagt ctattgaact     4680

ctgaaaggat tgcagtagga aaaactgctg tgaaatataa agtaaggggt tctttcctat     4740

gaatctcaaa caccacatta aaaagaaaag aatgaattgc agaagataaa atattagtct     4800

ggttctgatt gacattataa cctgaaggat cacacttaga tccagcatgg ttgtgcatac     4860

ctgacctgtt ggagcttaaa gagctgaggt aggtcttttt cttcatattt acaaccagtt     4920

tacacttcat gttgattccc aggcttttct gagtcattca gtgtgtcagt gtctcaaaag     4980

gagagaagta aaagaaagaa aggatggaag gaaggagaaa cagaagggag atgtacagtt     5040

atgaggaata ttatgctgag gctggaaagg tgcctcagtg atgcattaag aacacaggct     5100

gctcttccag aggaactgga cttgattgct aggacttaca tagtagctca taagtatccc     5160

caactcaatt gccagggaat ctcatgtgtt cttcatgccc cagacagaac agtcacagtg     5220

catgcactga attacatgca ggcaaaagat catatacata aaatgaaaca aaaatatctg     5280

taaagaaaga ggaaaatatc ttcttgccag tgactgatgt aggaaaacat aagagaaaag     5340

ataaaaaaaa taggtgctga ctctgcagtg aactcaggat tataaaatta tgaactcatc     5400

aacaggaact atgcttctag cacatcagat aaacatgttt ttctggatgg tgaaagaggc     5460

tgtaatttaa gatggagtct tatgtaagca aggacagtgt gggaagaatc cagcagctcc     5520

caacgtcata aactctattg ttgaattact tcctaaaagc agaagtcttt tgatgtttgt     5580

aaactacatt tactctatta cttgatactg ataccgccta ttgtggagat aattttttat     5640

cttacaaaac acaaagcata cagaaagtaa agactgacag ttattattcc agtttgtgaa     5700

acttccttgt acgttagaac tcagtttgat actagacatg aaatgtattc aggacaattc     5760

aaagcatatt ttcaattttc ctattgacaa ttgtttcttt tttgtttttg tttttgtttt     5820

tgagacaatt tttcatggac agtcgttaat agactttatc tgaaatgaag catacttgct     5880

agtaagaaag aaattatttt tagaaatggg aaattatatc atggtatatt atgaatcaaa     5940

ataaacctaa ttataatgaa tagctgaaag aacacggaaa tataggtaaa actatgtggc     6000

tatgatttta aaagatgcaa tattgagatt atatgtaata tttacatata tcctatatat     6060

aggattatat atgaaatata cataatcaca taatcataaa atattactaa tttaacactg     6120

ttttcccagt aaggattata ttaactctct aaaaatgtca tgtatacaag aatttgtcgt     6180

taattatcag atatataaaa attgtaacac agaagtggat gctcacagtc agctcttgga     6240

tggatcacag ggctcccaat ggaggagcta gagaaagtat ccaaggagct aaagggatct     6300

gcaaccctat agatggaaca acattatgaa ctaaccagta ccccagagct cttgactcta     6360

gctgcatatg tatcgaaaga tgacctagtc ggccatcact ggaaagagag gcccattgga     6420

cttgcaaact ttatatgccc cagtacaggg gaacaccagg gccaaaaagg gggagtgggt     6480

gggtagggga gtggggggcg gtatggggga cttttgggat agcattggaa atgtaaatga     6540

ggaaaatacc taataaaaaa ttaaaaaaac agaaatttta aaaaatgtat aattaaatgg     6600

catgctcaag ttattaggaa gccatgtata gaaaatgtat tatttatttc agtcttttaa     6660

tatctcatac tagtttagat ttcccttcta ttaaatttta tagtccatca tctggataat     6720

gttcaactga gtaatctcaa ttctctagaa tcaaaatatg ccaaagcctt ggatttcttt     6780

aattaaataa ggtagtgtct gtgtgtaaca ggttctgtgg agatttgatg gtaagaaacc     6840

agacacctta ggatccaaca ctcggctcta caagtggatc ccccagaatg accttcttgg     6900

taaggcaaag ttccactaca gctttggggc tatagtaata tacttatttg agaacagccc     6960

ccttctgagc cttcatattc cccctgtctt taatattatg atcaataatt atgtaaaact     7020

tcttctcact gcaggtcatc caaaaaccaa agcttttata gctcatggtg gaaccaatgg     7080

catctatgag gcgatctacc atggcattcc tattgttggt attcccttgt ttggggatca     7140

acctgataat attaaccaca tagtagccaa gggagcagct gttagagtgg actttgatac     7200

aatgtcaact acagaccttc tcactgcctt gaagactgtc attaatgacc cttcgtgagt     7260

ctatttgttg tttgtttcct tgtttgaagt tgttttggtt ttttttaagg tttttttttc     7320

ttttcttttc ttttttgttt tgtactatgt aaccacaaga ccagccaata actgatatag     7380

gtctgcttgc ttctgtctcc tgagtgctag aattaaaact atgtgcattc acgcttgatg     7440

gtgaataact attcctttga aaatattgct agattcacaa catcagattg atttttatcc     7500

tatttgaagg agaataattt tgaataactt tgtgatattg catgtctgaa atatgtgctt     7560

actttaacaa taaagatacc ttgaatttaa gtttcaataa atgagacatg ataagtctta     7620

aactattcta tatacataaa taatatcaca aatatatgtc tattggtaac aaggacacta     7680

tttcaagata gaatgtacat agtattcatg aaccatgatc ttaaatgaaa agttaaacat     7740

ttacccatat tttctgaagt tataaaactt ttggtaaaac tttaatttct ataatgatat     7800

gtgatattgc ataaccagta ctgaagaaat gagagagagt attaaattat taccataccc     7860

agagaacact gttggtagtt tcaaggtatt ccaatagaca aatgtaccta atgagaatat     7920

ccagaggcaa aataacagga gaaagtgcac ctggttcttc catacacagt ctcctagtcc     7980

aggaacacaa ttacattgct ttccatccag tcagaagtct gctggaaatt ctgttcaagg     8040

aagaataata acttagcaag tgttttcaaa acatgaatct gattataaaa agaaattagg     8100

aaacagagat agaagagaag aggagaaacc aaaactagag aggagatatc cagcatgaga     8160

tatgaccctg tagagtttaa aagaattcag tgtccacttc ttttcttaaa acttacacac     8220

acatacacac acacacacac acacacacac acacactttc tcttgccaat gtttgaaata     8280

ttgctcaact tcaaattaaa aataagtatt ctatggggaa taaagcaaaa ataagccaag     8340

tgtacctgag gagctggtat acaaggtaag ctcattagtt ggaggtaaat tcaggacttc     8400

attaagacca gtgtcaacta cacaccaagt tcaaaaaaaa acctgtacta aacaagactg     8460

tttcactgac ttccctgtca ctcaactgtc ctccctatca cctcataaaa catagtactt     8520

gtgtgggaag tttatgccat tcattttgag actcttgtgg gacttttccc caaaccaata     8580

aatgttaggg aagtcgacaa attagcttta attttagttg catgcattgt cctttcagct     8640

ataaagagaa tgccatgaga ttatccagaa tccaccatga ccagccaatg aagcccttgg     8700

accgagctgt cttctggatc gagtatgtca tgcgcaacaa gggagccaag caccttcgcc     8760

cagctctgca tgaccttacc tggttccagt accactctct ggatgtgatt gggttcctat     8820

tggtctgtgt ggtagctgtg gtattcatca ttgcaaaatg ttgcctcttt tgttgccata     8880

agactgctaa catgggaaag aagaaaaaag agtagcttca tgaaggctga agcagagagt     8940

cctgagagat gagcctctgc cagctgcttc cagcagaaac ctgttgtctg tcccaggtgc     9000

cttccctctg aaacaagaca gggtcaggac ttcattaaag atagctctca tagatgcact     9060

atatgttgaa tgcacgtaag gatttatgca agctatacac tcagagctct agaagcaaaa     9120

ttgtgtgttc agtttagaat gttttaatgt aaatgaggaa ctatacccaa caacaatcac     9180

tgaggttact gtagttcaca aaatttgcat aggcataaag cctttgaaaa acctctctaa     9240

atattagtta attttttatg ctctgtcttc atttaatgaa cttatttttc ttcccttcct     9300

tttttcttct ctttcatttt tttttgtatt gctcataaat aatagcgttc aggtacagaa     9360

catttgaaat agactcactt ttccatcaat ataaggaaag ccattgtttc tggttattaa     9420

ttgggtacag caaacttcca acaaatattt cctaaagggc ctgtggtgga ggctactctc     9480

cttcaatcag aagccttttt cagacactaa tcttcaagca tttactctta ctgctcctga     9540

cataaattcc agtacttggg agttcttagg cttggcaaga ttattgattt attttccttc     9600

ttatctctta ctcacaactg acctgaacac tgtcattctc attctgcctt ttgaagtaga     9660

tttaagctgc caaatgtccc attctctctc gctttgaaag tacacatcca agagaagatt     9720

atctttttaa gtcataccat cacctagctc atgttatatt tcgtatctga aatatccccc     9780

acagacacac aatgtacttt gctgattttg tttaactcat tcatacagaa tttcttacct     9840

tgattcaata aaatgttaaa atctt                                           9865


