﻿                         序列表

<110>  北京大学第一医院
       西北大学（Northwestern University）

<120>  一种可清除体内免疫球蛋白A的重组融合蛋白酶及其制备方法和在治疗IgA肾病中的应用

<160>  5

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  230
<212>  PRT
<213>  人(human)

<400>  1
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro 
225                 230 

<210>  3
<211>  720
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
atccatggga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg        60
aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga       120
tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg       180
tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg       240
aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg caccaggact       300
ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg       360
agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc       420
catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct       480
atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga       540
ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg       600
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc       660
acaaccacta cacgcagaag agcctctccc tgtctccggg taaaggtggc ggtggcggcg       720

<210>  2
<211>  1174
<212>  PRT
<213>  梭状芽胞杆菌(Clostridium)

<400>  2
Gly Ser Ser Lys Pro Asp Ile Lys Val Gly Asp Tyr Val Lys Met Gly 
1               5                   10                  15      
Val Tyr Asn Asn Ala Ser Ile Leu Trp Arg Cys Val Ser Ile Asp Asn 
            20                  25                  30          
Asn Gly Pro Leu Met Leu Ala Asp Lys Ile Val Asp Thr Leu Ala Tyr 
        35                  40                  45              
Asp Ala Lys Thr Asn Asp Asn Ser Asn Ser Lys Ser His Ser Arg Ser 
    50                  55                  60                  
Tyr Lys Arg Asp Asp Tyr Gly Ser Asn Tyr Trp Lys Asp Ser Asn Met 
65                  70                  75                  80  
Arg Ser Trp Leu Asn Ser Thr Ala Ala Glu Gly Lys Val Asp Trp Leu 
                85                  90                  95      
Cys Gly Asn Pro Pro Lys Asp Gly Tyr Val Ser Gly Val Gly Ala Tyr 
            100                 105                 110         
Asn Glu Lys Ala Gly Phe Leu Asn Ala Phe Ser Lys Ser Glu Ile Ala 
        115                 120                 125             
Ala Met Lys Thr Val Thr Gln Arg Ser Leu Val Ser His Pro Glu Tyr 
    130                 135                 140                 
Asn Lys Gly Ile Val Asp Gly Asp Ala Asn Ser Asp Leu Leu Tyr Tyr 
145                 150                 155                 160 
Thr Asp Ile Ser Glu Ala Val Ala Asn Tyr Asp Ser Ser Tyr Phe Glu 
                165                 170                 175     
Thr Thr Thr Glu Lys Val Phe Leu Leu Asp Val Lys Gln Ala Asn Ala 
            180                 185                 190         
Val Trp Lys Asn Leu Lys Gly Tyr Tyr Val Ala Tyr Asn Asn Asp Gly 
        195                 200                 205             
Met Ala Trp Pro Tyr Trp Leu Arg Thr Pro Val Thr Asp Cys Asn His 
    210                 215                 220                 
Asp Met Arg Tyr Ile Ser Ser Ser Gly Gln Val Gly Arg Tyr Ala Pro 
225                 230                 235                 240 
Trp Tyr Ser Asp Leu Gly Val Arg Pro Ala Phe Tyr Leu Asp Ser Glu 
                245                 250                 255     
Tyr Phe Val Thr Thr Ser Gly Ser Gly Ser Gln Ser Ser Pro Tyr Ile 
            260                 265                 270         
Gly Ser Ala Pro Asn Lys Gln Glu Asp Asp Tyr Thr Ile Ser Glu Pro 
        275                 280                 285             
Ala Glu Asp Ala Asn Pro Asp Trp Asn Val Ser Thr Glu Gln Ser Ile 
    290                 295                 300                 
Gln Leu Thr Leu Gly Pro Trp Tyr Ser Asn Asp Gly Lys Tyr Ser Asn 
305                 310                 315                 320 
Pro Thr Ile Pro Val Tyr Thr Ile Gln Lys Thr Arg Ser Asp Thr Glu 
                325                 330                 335     
Asn Met Val Val Val Val Cys Gly Glu Gly Tyr Thr Lys Ser Gln Gln 
            340                 345                 350         
Gly Lys Phe Ile Asn Asp Val Lys Arg Leu Trp Gln Asp Ala Met Lys 
        355                 360                 365             
Tyr Glu Pro Tyr Arg Ser Tyr Ala Asp Arg Phe Asn Val Tyr Ala Leu 
    370                 375                 380                 
Cys Thr Ala Ser Glu Ser Thr Phe Asp Asn Gly Gly Ser Thr Phe Phe 
385                 390                 395                 400 
Asp Val Ile Val Asp Lys Tyr Asn Ser Pro Val Ile Ser Asn Asn Leu 
                405                 410                 415     
His Gly Ser Gln Trp Lys Asn His Ile Phe Glu Arg Cys Ile Gly Pro 
            420                 425                 430         
Glu Phe Ile Glu Lys Ile His Asp Ala His Ile Lys Lys Lys Cys Asp 
        435                 440                 445             
Pro Asn Thr Ile Pro Ser Gly Ser Glu Tyr Glu Pro Tyr Tyr Tyr Val 
    450                 455                 460                 
His Asp Tyr Ile Ala Gln Phe Ala Met Val Val Asn Thr Lys Ser Asp 
465                 470                 475                 480 
Phe Gly Gly Ala Tyr Asn Asn Arg Glu Tyr Gly Phe His Tyr Phe Ile 
                485                 490                 495     
Ser Pro Ser Asp Ser Tyr Arg Ala Ser Lys Thr Phe Ala His Glu Phe 
            500                 505                 510         
Gly His Gly Leu Leu Gly Leu Gly Asp Glu Tyr Ser Asn Gly Tyr Leu 
        515                 520                 525             
Leu Asp Asp Lys Glu Leu Lys Ser Leu Asn Leu Ser Ser Val Glu Asp 
    530                 535                 540                 
Pro Glu Lys Ile Lys Trp Arg Gln Leu Leu Gly Phe Arg Asn Thr Tyr 
545                 550                 555                 560 
Thr Cys Arg Asn Ala Tyr Gly Ser Lys Met Leu Val Ser Ser Tyr Glu 
                565                 570                 575     
Cys Ile Met Arg Asp Thr Asn Tyr Gln Phe Cys Glu Val Cys Arg Leu 
            580                 585                 590         
Gln Gly Phe Lys Arg Met Ser Gln Leu Val Lys Asp Val Asp Leu Tyr 
        595                 600                 605             
Val Ala Thr Pro Glu Val Lys Glu Tyr Thr Gly Ala Tyr Ser Lys Pro 
    610                 615                 620                 
Ser Asp Phe Thr Asp Leu Glu Thr Ser Ser Tyr Tyr Asn Tyr Thr Tyr 
625                 630                 635                 640 
Asn Arg Asn Asp Arg Leu Leu Ser Gly Asn Ser Lys Ser Arg Phe Asn 
                645                 650                 655     
Thr Asn Met Asn Gly Lys Lys Ile Glu Leu Arg Thr Val Ile Gln Asn 
            660                 665                 670         
Ile Ser Asp Lys Asn Ala Arg Gln Leu Lys Phe Lys Met Trp Ile Lys 
        675                 680                 685             
His Ser Asp Gly Ser Val Ala Thr Asp Ser Ser Gly Asn Pro Leu Gln 
    690                 695                 700                 
Thr Val Gln Thr Phe Asp Ile Pro Val Trp Asn Asp Lys Ala Asn Phe 
705                 710                 715                 720 
Trp Pro Leu Gly Ala Leu Asp His Ile Lys Ser Asp Phe Asn Ser Gly 
                725                 730                 735     
Leu Lys Ser Cys Ser Leu Ile Tyr Gln Ile Pro Ser Asp Ala Gln Leu 
            740                 745                 750         
Lys Ser Gly Asp Thr Val Ala Phe Gln Val Leu Asp Glu Asn Gly Asn 
        755                 760                 765             
Val Leu Ala Asp Asp Asn Thr Glu Thr Gln Arg Tyr Thr Thr Val Ser 
    770                 775                 780                 
Ile Gln Tyr Lys Phe Glu Asp Gly Ser Glu Ile Pro Asn Thr Ala Gly 
785                 790                 795                 800 
Gly Thr Phe Thr Val Pro Tyr Gly Thr Lys Leu Asp Leu Thr Pro Ala 
                805                 810                 815     
Lys Thr Leu Tyr Asp Tyr Glu Phe Ile Lys Val Asp Gly Leu Asn Lys 
            820                 825                 830         
Pro Ile Val Ser Asp Gly Thr Val Val Thr Tyr Tyr Tyr Lys Asn Lys 
        835                 840                 845             
Asn Glu Glu His Thr His Asn Leu Thr Leu Val Ala Ala Lys Ala Ala 
    850                 855                 860                 
Thr Cys Thr Thr Ala Gly Asn Ser Ala Tyr Tyr Thr Cys Asp Gly Cys 
865                 870                 875                 880 
Asp Lys Trp Phe Ala Asp Ala Thr Gly Ser Val Glu Ile Thr Asp Lys 
                885                 890                 895     
Thr Ser Val Lys Ile Pro Ala Pro Gly His Thr Ala Gly Thr Glu Trp 
            900                 905                 910         
Lys Ser Asp Asp Thr Asn His Trp His Glu Cys Thr Val Ala Gly Cys 
        915                 920                 925             
Gly Val Ile Ile Glu Ser Thr Lys Ser Ala His Thr Ala Gly Glu Trp 
    930                 935                 940                 
Ile Val Asp Thr Pro Ala Thr Ala Thr Thr Ala Gly Thr Lys His Lys 
945                 950                 955                 960 
Glu Cys Thr Val Cys His Arg Val Leu Glu Thr Gln Pro Ile Pro Ser 
                965                 970                 975     
Thr Gly Thr Glu Leu Lys Ile Ile Ala Gly Asp Asn Gln Ile Tyr Asn 
            980                 985                 990         
Lys Ala Ser Gly Ser Asp Val Thr  Ile Thr Cys Asn Gly  Asp Phe Ala 
        995                 1000                 1005             
Lys Phe  Thr Gly Ile Lys Val  Asp Gly Ser Val Val  Asp Ser Ser Asn 
    1010                 1015                 1020                 
Tyr  Thr Ala Val Ser Gly  Ser Thr Val Leu Thr  Leu Lys Ala Ser Tyr  
1025                 1030                 1035                 1040 
Leu Gly Thr Leu Thr  Asp Gly Ser His Thr  Ile Thr Phe Val Tyr  Thr 
                1045                 1050                 1055     
Asp Gly Glu Ala  Asn Ala Asn Leu Thr  Val Arg Thr Ala Gly  Ser Gly 
            1060                 1065                 1070         
His Ile His  Asp Tyr Gly Thr Glu  Trp Lys Ser Asn Ala  Asp Asn His 
        1075                 1080                 1085             
Trp His  Glu Cys Asn Cys Gly  Asp Lys Lys Asp Glu  Ala Ala His Ser 
    1090                 1095                 1100                 
Phe  Lys Trp Val Val Asp  Lys Glu Ala Thr Ala  Thr Lys Lys Gly Ser  
1105                 1110                 1115                 1120 
Lys His Glu Glu Cys  Lys Ile Cys Gly Tyr  Lys Arg Ser Ala Val  Glu 
                1125                 1130                 1135     
Ile Pro Ala Thr  Gly Thr Ser Thr Ala  Pro Thr Asp Thr Thr  Lys Pro 
            1140                 1145                 1150         
Asn Asp Thr  Thr Lys Pro Gly Asn  Thr Asn Gly Ser Glu  Lys Ser Pro 
        1155                 1160                 1165             
Gln Thr  Gly Asp Asn Ser 
    1170                 

<210>  4
<211>  3534
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
ggatccagca aaccggacat caaagtgggc gactacgtga aaatgggtgt gtataataac        60
gcaagcatcc tgtggcgctg tgtgagcatc gacaacaatg gcccgctgat gctggccgat       120
aaaattgttg acacgctggc gtatgatgct aaaaccaacg acaattcgaa cagcaaatct       180
catagtcgtt cctacaaacg cgatgactac ggcagcaact attggaaaga tagtaatatg       240
cgctcctggc tgaactcaac cgcggccgag ggtaaagtgg attggctgtg cggcaatccg       300
ccgaaagacg gttacgtcag cggcgtgggt gcatataatg aaaaagctgg ttttctgaac       360
gcgttctcaa aatcggaaat tgcagctatg aaaacggtga cccagcgtag cctggtttct       420
catccggaat ataataaagg cattgttgat ggtgacgcga actcggatct gctgtattac       480
accgacatca gcgaagcagt ggctaactac gatagctctt attttgaaac cacgaccgaa       540
aaagttttcc tgctggatgt caaacaggcg aacgccgtct ggaaaaatct gaaaggctat       600
tacgtggctt acaacaatga tggtatggca tggccgtatt ggctgcgtac cccggtgacg       660
gattgtaatc atgacatgcg ctatattagt tcctcaggcc aggttggtcg ttacgctccg       720
tggtattctg atctgggcgt ccgtccggcg ttttacctgg acagtgaata tttcgtgacg       780
accagcggct ctggtagtca gtcgagcccg tacattggtt ccgcgccgaa caaacaagaa       840
gatgactata ccatctcaga accggcggaa gatgccaacc cggactggaa tgtttcgacg       900
gaacagagca ttcaactgac cctgggcccg tggtactcga atgatggtaa atatagcaac       960
ccgaccattc cggtgtatac catccagaaa acgcgctcgg ataccgaaaa catggtggtt      1020
gtcgtgtgcg gcgaaggtta taccaaatca cagcaaggca aatttatcaa tgatgttaaa      1080
cgtctgtggc aggacgctat gaaatatgaa ccgtaccgta gctatgcgga tcgctttaat      1140
gtgtatgcac tgtgtacggc ttccgaatca accttcgata acggcggttc tacctttttc      1200
gatgtgatcg ttgacaaata caactctccg gttatcagta acaatctgca tggcagtcag      1260
tggaaaaatc acatttttga acgctgcatc ggtccggaat tcattgaaaa aatccatgat      1320
gcccacatta agaaaaaatg tgacccgaac accatcccgt cgggtagcga atacgaaccg      1380
tattactatg tgcatgatta tattgcacag tttgctatgg ttgtcaatac caaatccgac      1440
ttcggcggtg catataacaa tcgcgaatac ggctttcact atttcatctc tccgagtgat      1500
tcctaccgtg cctctaaaac ctttgcacat gaattcggcc acggtctgct gggcctgggt      1560
gatgaatact cgaatggtta tctgctggat gacaaagaac tgaaaagcct gaacctgtct      1620
agtgtggaag atccggaaaa aattaaatgg cgtcagctgc tgggctttcg caatacgtac      1680
acctgccgta acgcgtatgg ttctaaaatg ctggtttcct catacgaatg tatcatgcgc      1740
gataccaact atcaattttg cgaagtctgt cgcctgcagg gcttcaaacg tatgagccaa      1800
ctggttaaag atgtcgacct gtatgtggcc acgccggaag ttaaagaata caccggtgca      1860
tatagtaaac cgtccgattt tacggacctg gaaacctcga gctactacaa ctacacctac      1920
aaccgtaacg atcgcctgct gagtggcaac tcaaaatcgc gtttcaatac gaacatgaat      1980
ggcaagaaaa ttgaactgcg caccgttatt cagaacatca gcgataaaaa cgcccgtcaa      2040
ctgaaattca aaatgtggat caaacattca gatggctcgg tggcaaccga ctctagtggt      2100
aacccgctgc agaccgtcca aacgtttgat attccggtgt ggaacgacaa agccaatttc      2160
tggccgctgg gcgcactgga tcacatcaaa tccgacttta attcaggtct gaaaagctgc      2220
tctctgattt atcagatccc gtctgatgct caactgaaaa gtggcgacac cgtggcgttc      2280
caggttctgg atgaaaacgg taatgtgctg gcggatgaca acacggaaac ccagcgctac      2340
acgaccgttt ctatccaata caaattcgaa gatggcagtg aaatcccgaa tacggcgggc      2400
ggtaccttca ccgttccgta tggtaccaaa ctggatctga cgccggccaa aaccctgtac      2460
gattacgaat tcatcaaagt tgacggcctg aataaaccga tcgtcagcga tggtaccgtg      2520
gttacgtact actacaaaaa caaaaacgaa gaacatacgc acaacctgac cctggtggcg      2580
gccaaagcag ctacctgtac gaccgcgggc aatagcgcct attacacctg cgatggttgt      2640
gacaaatggt ttgcagatgc taccggctcc gtggaaatta ccgacaaaac gtcagttaaa      2700
atcccggctc cgggtcatac cgccggtacg gaatggaaaa gcgatgacac gaaccattgg      2760
cacgaatgca ccgtcgcagg ctgtggtgtg attatcgaaa gcacgaaatc tgcgcacacc      2820
gccggcgaat ggattgtgga taccccggca acggcaacga ccgccggtac gaaacataaa      2880
gaatgcaccg tctgtcaccg tgtgctggaa acccagccga tcccgagcac gggtaccgaa      2940
ctgaaaatta tcgccggtga taaccaaatc tacaacaaag caagtggctc cgatgtcacg      3000
atcacctgca acggtgactt tgccaaattc accggcatta aagtggatgg tagcgtcgtg      3060
gactcctcaa attacaccgc cgtttcaggc tcgaccgtcc tgacgctgaa agcatcctat      3120
ctgggcacgc tgaccgatgg ttcacatacg attaccttcg tttacaccga cggtgaagca      3180
aacgctaatc tgaccgtccg cacggctggc tctggtcata tccacgatta tggcaccgaa      3240
tggaaaagta acgcggacaa tcattggcac gaatgcaatt gtggtgataa aaaagacgaa      3300
gcggcccatt cctttaaatg ggttgtcgat aaagaagcga cggccaccaa aaaaggctca      3360
aaacacgaag aatgcaaaat ctgtggttac aaacgttcgg ccgtggaaat cccggcaacg      3420
ggtaccagca cggcaccgac cgatacgacc aaaccgaacg acacgacgaa accgggtaat      3480
acgaatggct ccgaaaaatc tccgcaaacg ggcgacaata gttaatgaaa gctt            3534

<210>  5
<211>  1418
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Ser Lys Pro Asp Ile Lys Val Gly Asp Tyr Val Lys Met Gly Val Tyr 
                245                 250                 255     
Asn Asn Ala Ser Ile Leu Trp Arg Cys Val Ser Ile Asp Asn Asn Gly 
            260                 265                 270         
Pro Leu Met Leu Ala Asp Lys Ile Val Asp Thr Leu Ala Tyr Asp Ala 
        275                 280                 285             
Lys Thr Asn Asp Asn Ser Asn Ser Lys Ser His Ser Arg Ser Tyr Lys 
    290                 295                 300                 
Arg Asp Asp Tyr Gly Ser Asn Tyr Trp Lys Asp Ser Asn Met Arg Ser 
305                 310                 315                 320 
Trp Leu Asn Ser Thr Ala Ala Glu Gly Lys Val Asp Trp Leu Cys Gly 
                325                 330                 335     
Asn Pro Pro Lys Asp Gly Tyr Val Ser Gly Val Gly Ala Tyr Asn Glu 
            340                 345                 350         
Lys Ala Gly Phe Leu Asn Ala Phe Ser Lys Ser Glu Ile Ala Ala Met 
        355                 360                 365             
Lys Thr Val Thr Gln Arg Ser Leu Val Ser His Pro Glu Tyr Asn Lys 
    370                 375                 380                 
Gly Ile Val Asp Gly Asp Ala Asn Ser Asp Leu Leu Tyr Tyr Thr Asp 
385                 390                 395                 400 
Ile Ser Glu Ala Val Ala Asn Tyr Asp Ser Ser Tyr Phe Glu Thr Thr 
                405                 410                 415     
Thr Glu Lys Val Phe Leu Leu Asp Val Lys Gln Ala Asn Ala Val Trp 
            420                 425                 430         
Lys Asn Leu Lys Gly Tyr Tyr Val Ala Tyr Asn Asn Asp Gly Met Ala 
        435                 440                 445             
Trp Pro Tyr Trp Leu Arg Thr Pro Val Thr Asp Cys Asn His Asp Met 
    450                 455                 460                 
Arg Tyr Ile Ser Ser Ser Gly Gln Val Gly Arg Tyr Ala Pro Trp Tyr 
465                 470                 475                 480 
Ser Asp Leu Gly Val Arg Pro Ala Phe Tyr Leu Asp Ser Glu Tyr Phe 
                485                 490                 495     
Val Thr Thr Ser Gly Ser Gly Ser Gln Ser Ser Pro Tyr Ile Gly Ser 
            500                 505                 510         
Ala Pro Asn Lys Gln Glu Asp Asp Tyr Thr Ile Ser Glu Pro Ala Glu 
        515                 520                 525             
Asp Ala Asn Pro Asp Trp Asn Val Ser Thr Glu Gln Ser Ile Gln Leu 
    530                 535                 540                 
Thr Leu Gly Pro Trp Tyr Ser Asn Asp Gly Lys Tyr Ser Asn Pro Thr 
545                 550                 555                 560 
Ile Pro Val Tyr Thr Ile Gln Lys Thr Arg Ser Asp Thr Glu Asn Met 
                565                 570                 575     
Val Val Val Val Cys Gly Glu Gly Tyr Thr Lys Ser Gln Gln Gly Lys 
            580                 585                 590         
Phe Ile Asn Asp Val Lys Arg Leu Trp Gln Asp Ala Met Lys Tyr Glu 
        595                 600                 605             
Pro Tyr Arg Ser Tyr Ala Asp Arg Phe Asn Val Tyr Ala Leu Cys Thr 
    610                 615                 620                 
Ala Ser Glu Ser Thr Phe Asp Asn Gly Gly Ser Thr Phe Phe Asp Val 
625                 630                 635                 640 
Ile Val Asp Lys Tyr Asn Ser Pro Val Ile Ser Asn Asn Leu His Gly 
                645                 650                 655     
Ser Gln Trp Lys Asn His Ile Phe Glu Arg Cys Ile Gly Pro Glu Phe 
            660                 665                 670         
Ile Glu Lys Ile His Asp Ala His Ile Lys Lys Lys Cys Asp Pro Asn 
        675                 680                 685             
Thr Ile Pro Ser Gly Ser Glu Tyr Glu Pro Tyr Tyr Tyr Val His Asp 
    690                 695                 700                 
Tyr Ile Ala Gln Phe Ala Met Val Val Asn Thr Lys Ser Asp Phe Gly 
705                 710                 715                 720 
Gly Ala Tyr Asn Asn Arg Glu Tyr Gly Phe His Tyr Phe Ile Ser Pro 
                725                 730                 735     
Ser Asp Ser Tyr Arg Ala Ser Lys Thr Phe Ala His Glu Phe Gly His 
            740                 745                 750         
Gly Leu Leu Gly Leu Gly Asp Glu Tyr Ser Asn Gly Tyr Leu Leu Asp 
        755                 760                 765             
Asp Lys Glu Leu Lys Ser Leu Asn Leu Ser Ser Val Glu Asp Pro Glu 
    770                 775                 780                 
Lys Ile Lys Trp Arg Gln Leu Leu Gly Phe Arg Asn Thr Tyr Thr Cys 
785                 790                 795                 800 
Arg Asn Ala Tyr Gly Ser Lys Met Leu Val Ser Ser Tyr Glu Cys Ile 
                805                 810                 815     
Met Arg Asp Thr Asn Tyr Gln Phe Cys Glu Val Cys Arg Leu Gln Gly 
            820                 825                 830         
Phe Lys Arg Met Ser Gln Leu Val Lys Asp Val Asp Leu Tyr Val Ala 
        835                 840                 845             
Thr Pro Glu Val Lys Glu Tyr Thr Gly Ala Tyr Ser Lys Pro Ser Asp 
    850                 855                 860                 
Phe Thr Asp Leu Glu Thr Ser Ser Tyr Tyr Asn Tyr Thr Tyr Asn Arg 
865                 870                 875                 880 
Asn Asp Arg Leu Leu Ser Gly Asn Ser Lys Ser Arg Phe Asn Thr Asn 
                885                 890                 895     
Met Asn Gly Lys Lys Ile Glu Leu Arg Thr Val Ile Gln Asn Ile Ser 
            900                 905                 910         
Asp Lys Asn Ala Arg Gln Leu Lys Phe Lys Met Trp Ile Lys His Ser 
        915                 920                 925             
Asp Gly Ser Val Ala Thr Asp Ser Ser Gly Asn Pro Leu Gln Thr Val 
    930                 935                 940                 
Gln Thr Phe Asp Ile Pro Val Trp Asn Asp Lys Ala Asn Phe Trp Pro 
945                 950                 955                 960 
Leu Gly Ala Leu Asp His Ile Lys Ser Asp Phe Asn Ser Gly Leu Lys 
                965                 970                 975     
Ser Cys Ser Leu Ile Tyr Gln Ile Pro Ser Asp Ala Gln Leu Lys Ser 
            980                 985                 990         
Gly Asp Thr Val Ala Phe Gln Val  Leu Asp Glu Asn Gly  Asn Val Leu 
        995                 1000                 1005             
Ala Asp  Asp Asn Thr Glu Thr  Gln Arg Tyr Thr Thr  Xaa Xaa Xaa Xaa 
    1010                 1015                 1020                 
Xaa  Xaa Val Ser Ile Gln  Tyr Lys Phe Glu Asp  Gly Ser Glu Ile Pro  
1025                 1030                 1035                 1040 
Asn Thr Ala Gly Gly  Thr Phe Thr Val Pro  Tyr Gly Thr Lys Leu  Asp 
                1045                 1050                 1055     
Leu Thr Pro Ala  Lys Thr Leu Tyr Asp  Tyr Glu Phe Ile Lys  Val Asp 
            1060                 1065                 1070         
Gly Leu Asn  Lys Pro Ile Val Ser  Asp Gly Thr Val Val  Thr Tyr Tyr 
        1075                 1080                 1085             
Tyr Lys  Asn Lys Asn Glu Glu  His Thr His Asn Leu  Thr Leu Val Ala 
    1090                 1095                 1100                 
Ala  Lys Ala Ala Thr Cys  Thr Thr Ala Gly Asn  Ser Ala Tyr Tyr Thr  
1105                 1110                 1115                 1120 
Cys Asp Gly Cys Asp  Lys Trp Phe Ala Asp  Ala Thr Gly Ser Val  Glu 
                1125                 1130                 1135     
Ile Thr Asp Lys  Thr Ser Val Lys Ile  Pro Ala Pro Gly His  Thr Ala 
            1140                 1145                 1150         
Gly Thr Glu  Trp Lys Ser Asp Asp  Thr Asn His Trp His  Glu Cys Thr 
        1155                 1160                 1165             
Val Ala  Gly Cys Gly Val Ile  Ile Glu Ser Thr Lys  Ser Ala His Thr 
    1170                 1175                 1180                 
Ala  Gly Glu Trp Ile Val  Asp Thr Pro Ala Thr  Ala Thr Thr Ala Gly  
1185                 1190                 1195                 1200 
Thr Lys His Lys Glu  Cys Thr Val Cys His  Arg Val Leu Glu Thr  Gln 
                1205                 1210                 1215     
Pro Ile Pro Ser  Thr Gly Thr Glu Leu  Lys Ile Ile Ala Gly  Asp Asn 
            1220                 1225                 1230         
Gln Ile Tyr  Asn Lys Ala Ser Gly  Ser Asp Val Thr Ile  Thr Cys Asn 
        1235                 1240                 1245             
Gly Asp  Phe Ala Lys Phe Thr  Gly Ile Lys Val Asp  Gly Ser Val Val 
    1250                 1255                 1260                 
Asp  Ser Ser Asn Tyr Thr  Ala Val Ser Gly Ser  Thr Val Leu Thr Leu  
1265                 1270                 1275                 1280 
Lys Ala Ser Tyr Leu  Gly Thr Leu Thr Asp  Gly Ser His Thr Ile  Thr 
                1285                 1290                 1295     
Phe Val Tyr Thr  Asp Gly Glu Ala Asn  Ala Asn Leu Thr Val  Arg Thr 
            1300                 1305                 1310         
Ala Gly Ser  Gly His Ile His Asp  Tyr Gly Thr Glu Trp  Lys Ser Asn 
        1315                 1320                 1325             
Ala Asp  Asn His Trp His Glu  Cys Asn Cys Gly Asp  Lys Lys Asp Glu 
    1330                 1335                 1340                 
Ala  Ala His Ser Phe Lys  Trp Val Val Asp Lys  Glu Ala Thr Ala Thr  
1345                 1350                 1355                 1360 
Lys Lys Gly Ser Lys  His Glu Glu Cys Lys  Ile Cys Gly Tyr Lys  Arg 
                1365                 1370                 1375     
Ser Ala Val Glu  Ile Pro Ala Thr Gly  Thr Ser Thr Ala Pro  Thr Asp 
            1380                 1385                 1390         
Thr Thr Lys  Pro Asn Asp Thr Thr  Lys Pro Gly Asn Thr  Asn Gly Ser 
        1395                 1400                 1405             
Glu Lys  Ser Pro Gln Thr Gly  Asp Asn Ser 
    1410                 1415             

