                       SEQUENCE LISTING

<110>  Gadeta B.V.

<120>  CELLULAR REPORTER AND METHODS OF USING THE SAME

<130>  P6100267PCT

<150>  EP21167702.6
<151>  09-04-2021

<160>  174

<210>  1
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-EC

<400>  1
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                200                 205 


<210>  2
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L

<400>  2
Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
1               5                   10                  15  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                20                  25                  30  

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                35                  40                  45  

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                50                  55                  60  

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                65                  70                  75  

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                80                  85                  90  

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                95                  100                 105 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                110                 115                 120 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                125                 130             


<210>  3
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86

<400>  3
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro 
                245         


<210>  4
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK

<400>  4
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His Val Tyr 
                200                 205                 210 

Leu Pro 
        


<210>  5
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Reverse 41BBL

<400>  5
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala 
                215                 220 


<210>  6
<211>  347
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL - CD86 IgV domain

<400>  6
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                200                 205                 210 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                215                 220                 225 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                230                 235                 240 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                245                 250                 255 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                260                 265                 270 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                275                 280                 285 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                290                 295                 300 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                305                 310                 315 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                320                 325                 330 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                335                 340                 345 

Ala Asn 
        


<210>  7
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD

<400>  7
Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15  

Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                20                  25                  30  

Ser Thr Leu Ala Lys Ile 
                35      


<210>  8
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-REV

<400>  8
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg 
                35      


<210>  9
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-TM

<400>  9
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln 
                20                  25                  30  

Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                35                  40                  45  

Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
                50                  55                  60  

Ala Lys Ile 
            


<210>  10
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD

<400>  10
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15  

Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                20                  25                  30  

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40          


<210>  11
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-REV

<400>  11
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  





<210>  12
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-ICD

<400>  12
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp 
                35      


<210>  13
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-ICD

<400>  13
Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu 
1               5                   10                  15  

Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys 
                20                  25                  30  

Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe 
                35                  40                  45  

Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu 
                50                  55                  60  

Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu 
                65                  70                  75  

Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu 
                80                  85                  90  

Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
                95                  100                 105 

Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln 
                110                 115                 120 

Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile 
                125                 130                 135 

Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His 
                140                 145                 150 

Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg 
                155                 160                 165 

Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met 
                170                 175                 180 

Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn 
                185                 190                 195 

Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser 
                200                 205                 210 

Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                215                 220                 


<210>  14
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-TM

<400>  14
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
                20                  25                  30  

Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                35                  40                  45  

Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                50                  55                  60  

Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                65                  


<210>  15
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR

<400>  15
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR-REV

<400>  16
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15  

His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
                20                  25                  30  

Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40          


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain OX40

<400>  17
Pro Ile Gln Glu Glu Gln 
1               5       


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YMTLN motif

<400>  18
Tyr Met Thr Leu Asn 
1               5   


<210>  19
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain 41BB

<400>  19
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
1               5                   10                  15  

Glu Glu Glu 
            


<210>  20
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-TM

<400>  20
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu 
                20      


<210>  21
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-TM

<400>  21
Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
1               5                   10                  15  

Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                20                  25          


<210>  22
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-TM

<400>  22
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
                20                  25          


<210>  23
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-TM

<400>  23
Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
1               5                   10                  15  

Ala Cys Ala Val Phe Leu 
                20      


<210>  24
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-TM

<400>  24
Ile Leu Leu Gly Ile Ser Gly Thr Val Asn Gly Ile Leu Thr Leu 
1               5                   10                  15  

Thr Leu Ile Ser Leu Ile 
                20      


<210>  25
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-TM

<400>  25
Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
1               5                   10                  15  

Phe Cys Leu Ile Leu Trp 
                20      


<210>  26
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-TM

<400>  26
Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu 
1               5                   10                  15  

Val Ala Val Leu 
                


<210>  27
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-TM

<400>  27
Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala 
1               5                   10                  15  

Ala Ile Ile Phe Gly Val 
                20      


<210>  28
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  28
Thr Ser Gly Ser 
1               


<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  29
Gly Gly Gly Gly Ser 
1               5   


<210>  30
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  30
Gly Gly Gly Ser 
1               


<210>  31
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  31
gg                                                                     2


<210>  32
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  32
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg 
1               5                   10                  15  

Ser Leu Asp 
            


<210>  33
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  33
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  34
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  35
Glu Ala Ala Ala Lys 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  36
Glu Ala Ala Ala Arg 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  37
Pro Ala Pro Ala Pro 
1               5   


<210>  38
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  38
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  39
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  39
Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr 
1               5                   10                  15  

Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala 
                20                  25                  30  

Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln 
                35                  40                  45  

Ile His Asp Ile Thr Gly 
                50      


<210>  40
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  40
Gly Gly Ser 
1           


<210>  41
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  41
Ser Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser 
                20                  25                  30  





<210>  42
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  42
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Leu Gln 
                20  


<210>  43
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  43
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                20                  25      


<210>  44
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  





<210>  45
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40ICD

<400>  45
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 


<210>  46
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  46
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Pro 
                35                  40                  45  

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
                50                  55                  60  

Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
                65                  70                  75  

Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                80                  85                  90  

Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                95                  100                 105 

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                110                 115                 120 

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                125                 130                 135 

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                140                 145                 150 

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
                155                 160                 165 

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                170                 175                 180 

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                185                 190                 195 

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                200                 205                 210 

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                215                 220                 225 

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
                230                 235                 240 

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                245                 250                 255 

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                260                 265                 270 

Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280             


<210>  47
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-NKp80

<400>  47
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Ala Ser Asp Ala Ser Leu Asp Pro 
                35                  40                  45  

Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val 
                50                  55                  60  

Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
                65                  70                  75  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                80                  85                  90  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                95                  100                 105 

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                110                 115                 120 

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                125                 130                 135 

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                140                 145                 150 

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                155                 160                 165 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                170                 175                 180 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                185                 190                 195 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                200                 205                 210 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                215                 220                 225 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                230                 235                 240 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                245                 250                 255 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                260                 265                 270 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                275                 280                 285 

Arg Ser Glu 
            


<210>  48
<211>  264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-NKp80

<400>  48
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Lys Trp Ala Leu Val Ala Gly Leu 
                35                  40                  45  

Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala 
                50                  55                  60  

Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                65                  70                  75  

Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
                80                  85                  90  

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                95                  100                 105 

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                110                 115                 120 

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                125                 130                 135 

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                140                 145                 150 

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                155                 160                 165 

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                170                 175                 180 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                185                 190                 195 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                200                 205                 210 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                215                 220                 225 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                230                 235                 240 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                245                 250                 255 

Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 


<210>  49
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BB

<400>  49
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Thr Ser Gly Ser Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     


<210>  50
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L- 41BB

<400>  50
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     


<210>  51
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BBrev

<400>  51
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val 
                50                  55                  60  

Gly Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu 
                65                  70                  75  

Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr 
                80                  85                  90  

Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr 
                95                  100                 105 

Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
                110                 115                 120 

Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
                125                 130                 135 

Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr 
                140                 145                 150 

Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
                155                 160                 165 

Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
                170                 175                 180 

Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                185                 190                 195 

Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
                200                 205                 210 

Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                215                 220                 225 

Pro Gly Glu Phe Cys Val Leu 
                230         


<210>  52
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-OX40

<400>  52
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Gly 
                320                 325                 330 

Ser Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro 
                335                 340                 345 

Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                350                 355                 360 

Ala His Ser Thr Leu Ala Lys Ile 
                365             


<210>  53
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86delP276-OX40

<400>  53
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Gly Arg Asp Gln Arg Leu Pro Pro Asp 
                275                 280                 285 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                290                 295                 300 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                305                 310             


<210>  54
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL

<400>  54
Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
1               5                   10                  15  

Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
                20                  25                  30  

Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val 
                35                  40                  45  

Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
                50                  55                  60  

Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
                65                  70                  75  

Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
                80                  85                  90  

Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
                95                  100                 105 

Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                110                 115                 120 

Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
                125                 130                 135 

Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
                140                 145                 150 

Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
                155                 160                 165 

Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                170                 175                 180 

Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
                185                 190                 195 

Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                200                 205                 210 

Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                215                 220                 225 

Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
                230                 235                 240 

Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250         


<210>  55
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto

<400>  55
Met Ser Lys Ser Thr Gly Ser Trp Ala Leu Val Ala Gly Leu Leu 
1               5                   10                  15  

Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys 
                20                  25                  30  

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala 
                35                  40                  45  

Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                50                  55                  60  

Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                65                  70                  75  

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                80                  85                  90  

Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                95                  100                 105 

Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
                110                 115                 120 

Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
                125                 130                 135 

Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
                140                 145                 150 

Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
                155                 160                 165 

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                170                 175                 180 

Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
                185                 190                 195 

His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                200                 205                 210 

Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                215                 220                 225 

Gly Leu Pro Ser Pro Arg Ser Glu 
                230             


<210>  56
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W

<400>  56
Met Glu Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                20                  25                  30  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                35                  40                  45  

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                50                  55                  60  

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                65                  70                  75  

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                80                  85                  90  

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                95                  100                 105 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                110                 115                 120 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                125                 130                 135 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                140                 145                 150 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                155                 160                 165 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                170                 175                 180 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                185                 190                 195 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                200                 205                 210 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                215                 220                 225 

Arg Ser Glu 
            


<210>  57
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40rev

<400>  57
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 


<210>  58
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-rev extra-OX40tm-cyto

<400>  58
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala Val Ala Ala Ile Leu 
                215                 220                 225 

Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu 
                230                 235                 240 

Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
                245                 250                 255 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                260                 265                 270 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                275                 280             


<210>  59
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-OX40

<400>  59
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 


<210>  60
<211>  281
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  60
Met Glu Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu 
1               5                   10                  15  

Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala 
                20                  25                  30  

Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Trp Pro Pro Ala 
                35                  40                  45  

Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
                50                  55                  60  

Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
                65                  70                  75  

Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
                80                  85                  90  

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
                95                  100                 105 

Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
                110                 115                 120 

Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                125                 130                 135 

Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
                140                 145                 150 

Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                155                 160                 165 

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                170                 175                 180 

Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                185                 190                 195 

Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                200                 205                 210 

Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
                215                 220                 225 

Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
                230                 235                 240 

Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                245                 250                 255 

Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
                260                 265                 270 

Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280     


<210>  61
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto-OX40rev

<400>  61
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 


<210>  62
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40ENrev

<400>  62
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    


<210>  63
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40EN

<400>  63
Met Leu Gly Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
1               5                   10                  15  

Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                20                  25                  30  

Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    


<210>  64
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-13alink-OX40

<400>  64
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Ser Leu Asn Gly Gly Gly 
                35                  40                  45  

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                50                  55                  60  

Gly Ser Gly Gly Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu 
                65                  70                  75  

Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
                80                  85                  90  

Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
                95                  100                 105 

Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
                110                 115                 120 

Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                125                 130                 135 

Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                140                 145                 150 

Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                155                 160                 165 

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                170                 175                 180 

Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
                185                 190                 195 

Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
                200                 205                 210 

Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                215                 220                 225 

Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
                230                 235                 240 

Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                245                 250                 255 

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                260                 265                 270 

Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                275                 280                 285 

Pro Ser Pro Arg Ser Glu 
                290     


<210>  65
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BBrev

<400>  65
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
                50                  55                  60  

Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser 
                65                  70                  75  

His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
                80                  85                  90  

Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                95                  100                 105 

Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
                110                 115                 120 

Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val 
                125                 130                 135 

Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
                140                 145                 150 

Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu 
                155                 160                 165 

Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr 
                170                 175                 180 

Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile 
                185                 190                 195 

His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205 


<210>  66
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L WT

<400>  66
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala 
1               5                   10                  15  

Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val 
                20                  25                  30  

Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu 
                35                  40                  45  

His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln 
                50                  55                  60  

Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
                65                  70                  75  

Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn 
                80                  85                  90  

Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu 
                95                  100                 105 

Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln 
                110                 115                 120 

Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
                125                 130                 135 

Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
                140                 145                 150 

Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val 
                155                 160                 165 

Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
                170                 175                 180 

Cys Val Leu 
            


<210>  67
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BB

<400>  67
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly 
                50                  55                  60  

Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                65                  70                  75  

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
                80                  85                  90  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                95                  100                 105 

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                110                 115                 120 

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                125                 130                 135 

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                140                 145                 150 

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                155                 160                 165 

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                170                 175                 180 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                185                 190                 195 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205             


<210>  68
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86 WT

<400>  68
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                320                 325                 


<210>  69
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-delP276

<400>  69
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro 
                275     


<210>  70
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto

<400>  70
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp 
                260                 265             


<210>  71
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto-IL18RAP

<400>  71
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Ser Ala 
                260                 265                 270 

Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr 
                275                 280                 285 

Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp 
                290                 295                 300 

Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala 
                305                 310                 315 

Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro 
                320                 325                 330 

Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu 
                335                 340                 345 

Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser 
                350                 355                 360 

Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn 
                365                 370                 375 

Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn 
                380                 385                 390 

Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe 
                395                 400                 405 

Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys 
                410                 415                 420 

Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
                425                 430                 435 

Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met 
                440                 445                 450 

Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile 
                455                 460                 465 

Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr 
                470                 475                 480 

Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                485                 490 


<210>  72
<211>  551
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-IL18RAP

<400>  72
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Ser 
                320                 325                 330 

Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg 
                335                 340                 345 

Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe 
                350                 355                 360 

Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu 
                365                 370                 375 

Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe 
                380                 385                 390 

Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu 
                395                 400                 405 

Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val 
                410                 415                 420 

Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro 
                425                 430                 435 

Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val 
                440                 445                 450 

Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys 
                455                 460                 465 

Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
                470                 475                 480 

Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys 
                485                 490                 495 

Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His 
                500                 505                 510 

Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg 
                515                 520                 525 

Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu 
                530                 535                 540 

Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                545                 550     


<210>  73
<211>  437
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86IgV-41BBL-OX40

<400>  73
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                290                 295                 300 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                305                 310                 315 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                320                 325                 330 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                335                 340                 345 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                350                 355                 360 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                365                 370                 375 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                380                 385                 390 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                395                 400                 405 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                410                 415                 420 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                425                 430                 435 

Ala Asn 
        


<210>  74
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK WT

<400>  74
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys Ala Leu Thr 
                230                 235                 240 

Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg Leu Ser 
                245                 250                 255 

Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His Thr 
                260                 265                 270 

Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
                275                 280                 285 

Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp 
                290                 295                 300 

Gln Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr 
                305                 310                 315 

Ala Gln Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr 
                320                 325                 330 

Glu Ile Glu Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu 
                335                 340                 345 

Tyr Met Asp Arg Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu 
                350                 355                 360 

Thr Glu Pro Gly Ser Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu 
                365                 370                 375 

Glu Val Gly Glu Asn Asp Ser Leu Ser Gln Cys Phe Thr Gly Thr 
                380                 385                 390 

Gln Ser Thr Val Gly Ser Glu Ser Cys Asn Cys Thr Glu Pro Leu 
                395                 400                 405 

Cys Arg Thr Asp Trp Thr Pro Met Ser Ser Glu Asn Tyr Leu Gln 
                410                 415                 420 

Lys Glu Val Asp Ser Gly His Cys Pro His Trp Ala Ala Ser Pro 
                425                 430                 435 

Ser Pro Asn Trp Ala Asp Val Cys Thr Gly Cys Arg Asn Pro Pro 
                440                 445                 450 

Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro Lys Arg Gly Pro 
                455                 460                 465 

Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro Glu Glu Glu 
                470                 475                 480 

Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly Ala Asp 
                485                 490                 495 

Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly Ser 
                500                 505                 510 

Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
                515                 520                 525 

Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys 
                530                 535                 540 

Gly Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly 
                545                 550                 555 

Ala Ala Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu 
                560                 565                 570 

Thr Leu Ala Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe 
                575                 580                 585 

Pro Asp Pro Cys Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys 
                590                 595                 600 

Ala Ser Arg Pro Val Gln Glu Gln Gly Gly Ala Lys Ala 
                605                 610             


<210>  75
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANKmincyto

<400>  75
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val 
                230 


<210>  76
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-OX40

<400>  76
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Val 
                200                 205                 210 

Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
                215                 220                 225 

Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg 
                230                 235                 240 

Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg 
                245                 250                 255 

Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
                260                 265                 270 

Lys Ile 
        


<210>  77
<211>  278
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-41BB

<400>  77
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Ile 
                200                 205                 210 

Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
                215                 220                 225 

Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
                230                 235                 240 

Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255 

Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                260                 265                 270 

Glu Glu Glu Gly Gly Cys Glu Leu 
                275             


<210>  78
<211>  452
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-IL18RAP

<400>  78
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val 
                215                 220                 225 

Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu 
                230                 235                 240 

Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu 
                245                 250                 255 

Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp 
                260                 265                 270 

Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
                275                 280                 285 

Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly 
                290                 295                 300 

Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val 
                305                 310                 315 

Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly 
                320                 325                 330 

Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe 
                335                 340                 345 

Glu Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu 
                350                 355                 360 

Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser 
                365                 370                 375 

Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val 
                380                 385                 390 

Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp 
                395                 400                 405 

Ala Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe 
                410                 415                 420 

Thr Trp Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys 
                425                 430                 435 

Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys 
                440                 445                 450 

Glu Trp 
        


<210>  79
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40WT mincyto

<400>  79
Met Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln Gly 
1               5                   10                  15  

Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
                20                  25                  30  

Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys 
                35                  40                  45  

Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr 
                50                  55                  60  

Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val 
                65                  70                  75  

Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr 
                80                  85                  90  

Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
                95                  100                 105 

Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu 
                110                 115                 120 

Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val 
                125                 130                 135 

Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly 
                140                 145                 150 

Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                155                 160                 165 





<210>  80
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Q8

<400>  80
Met Gly Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Ile Pro 
1               5                   10                  15  

Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly 
                20                  25                  30  

Phe Met Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
                35                  40                  45  

Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
                50                  55                  60  

Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                65                  70                  75  

Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                80                  85                  90  

Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                95                  100                 105 

Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                110                 115                 120 

Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
                125                 130                 135 

Pro Val Val 
            


<210>  81
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  eGFP

<400>  81
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
1               5                   10                  15  

Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
                20                  25                  30  

Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                35                  40                  45  

Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                50                  55                  60  

Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
                65                  70                  75  

Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                80                  85                  90  

Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                95                  100                 105 

Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                110                 115                 120 

Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                125                 130                 135 

Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                140                 145                 150 

Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
                155                 160                 165 

Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
                170                 175                 180 

Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                185                 190                 195 

Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                200                 205                 210 

Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                215                 220                 225 

Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                230                 235                 


<210>  82
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Fe11

<400>  82
Cys Ala Leu Gly Asp Ser Tyr Gly Gly Gly Pro Leu Tyr Thr Asp 
1               5                   10                  15  

Lys Leu Ile Phe 
                


<210>  83
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD2 cl3

<400>  83
Cys Ala Cys Asp Leu Leu Gly Tyr Thr Asp Lys Leu Ile Phe 
1               5                   10                  


<210>  84
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3 VD2 cl5

<400>  84
Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile 
1               5                   10                  15  

Phe Gly 
        


<210>  85
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG5 Fe11

<400>  85
Cys Ala Thr Trp Asp Arg Pro Glu Ile Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  15  





<210>  86
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG cl3

<400>  86
Cys Ala Leu Trp Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15  





<210>  87
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG9 cl5

<400>  87
Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15  

Phe 
    


<210>  88
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD cl3

<400>  88
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala 
1               5                   10                  15  

Gly Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val 
                20                  25                  30  

Pro Val Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys 
                35                  40                  45  

Gly Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr 
                50                  55                  60  

Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr 
                65                  70                  75  

Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala 
                80                  85                  90  

Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser Glu Arg Asp 
                95                  100                 105 

Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Leu Leu Gly Tyr Thr Asp 
                110                 115                 120 

Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                125                 130                 135 





<210>  89
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG cl3

<400>  89
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Glu Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr 
                125                 130                 135 

Lys Leu Ile Ile Thr 
                140 


<210>  90
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD cl5

<400>  90
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala 
1               5                   10                  15  

Gly Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val 
                20                  25                  30  

Pro Val Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys 
                35                  40                  45  

Gly Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr 
                50                  55                  60  

Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr 
                65                  70                  75  

Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala 
                80                  85                  90  

Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser Glu Arg Asp 
                95                  100                 105 

Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp 
                110                 115                 120 

Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu 
                125                 130                 135 

Pro Arg 
        


<210>  91
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG cl5

<400>  91
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly 
                125                 130                 135 

Thr Lys Leu Ile Ile Thr 
                140     


<210>  92
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD Fe11

<400>  92
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Ser Tyr Gly Gly Gly 
                110                 115                 120 

Pro Leu Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val 
                125                 130                 135 

Thr Val Glu Pro Arg 
                140 


<210>  93
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG Fe11

<400>  93
Met Gly Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Gly Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Arg Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Ile Asn Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Lys Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Arg Pro Glu 
                110                 115                 120 

Ile Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val 
                125                 130                 135 

Thr 
    


<210>  94
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 E113

<400>  94
Cys Ala Thr Trp Asp Gly Pro Pro Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  


<210>  95
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG2 F4

<400>  95
Cys Ala Thr Trp Asp Gly Gln Lys Lys Leu Phe 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 Zi11

<400>  96
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      


<210>  97
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 D37

<400>  97
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            


<210>  98
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 E113

<400>  98
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            


<210>  99
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 F4

<400>  99
Cys Ala Leu Gly Glu Leu Arg Tyr Trp Gly Ile Val Asp Lys Leu 
1               5                   10                  15  

Ile Phe 
        


<210>  100
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Zi11

<400>  100
Cys Ala Leu Gly Glu Leu Arg Gly Gln Ile Ser Phe Leu Tyr Leu 
1               5                   10                  15  

Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                20                  25  


<210>  101
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 E57

<400>  101
Cys Ala Thr Trp Asp Gly Phe Tyr Tyr Lys Lys Leu Phe 
1               5                   10              


<210>  102
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 E57

<400>  102
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            


<210>  103
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD E113

<400>  103
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 


<210>  104
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG E113

<400>  104
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Pro Pro 
                110                 115                 120 

Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 135 





<210>  105
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD F4

<400>  105
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Leu Arg Tyr Trp Gly 
                110                 115                 120 

Ile Val Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val 
                125                 130                 135 

Glu Pro Arg 
            


<210>  106
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG F4

<400>  106
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Asn Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Gln Tyr Tyr Asp Ser Tyr Asn Ser Lys Val 
                65                  70                  75  

Val Leu Glu Ser Gly Val Ser Pro Gly Lys Tyr Tyr Thr Tyr Ala 
                80                  85                  90  

Ser Thr Arg Asn Asn Leu Arg Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Gln Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         


<210>  107
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD Zi11

<400>  107
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Leu Arg Gly Gln Ile 
                110                 115                 120 

Ser Phe Leu Tyr Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                125                 130                 135 

Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 145     


<210>  108
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG Zi11

<400>  108
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         


<210>  109
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD D37

<400>  109
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 


<210>  110
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG D37

<400>  110
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Met 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         


<210>  111
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD E57

<400>  111
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 


<210>  112
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG E57

<400>  112
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Phe Tyr 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 


<210>  113
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 D37

<400>  113
Cys Ala Thr Trp Asp Asn Tyr Met Lys Leu Phe 
1               5                   10      


<210>  114
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 F2

<400>  114
Cys Ala Ser Ser Tyr Thr Leu Lys Leu Gly Asp Thr Pro Gly Arg 
1               5                   10                  15  

Val Arg Asp Trp Lys Leu Ile Phe 
                20              


<210>  115
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG4 F2

<400>  115
Cys Ala Thr Trp Asp Gly Pro Pro Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  


<210>  116
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 Ze11

<400>  116
Cys Ala Leu Gly Asp Tyr Leu Gly Asp Lys Tyr Pro Ser Tyr Asp 
1               5                   10                  15  

Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile Phe 
                20                  25      


<210>  117
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 Ze11

<400>  117
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      


<210>  118
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD5 B23

<400>  118
Cys Ala Ala Ser Ser Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys 
1               5                   10                  15  

Leu Ile Phe 
            


<210>  119
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 B23

<400>  119
Cys Ala Thr Trp Asp Asn Tyr Lys Lys Leu Phe 
1               5                   10      


<210>  120
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD F2

<400>  120
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Ser Ser Tyr Thr Leu Lys Leu Gly 
                110                 115                 120 

Asp Thr Pro Gly Arg Val Arg Asp Trp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 


<210>  121
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG F2

<400>  121
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Pro Pro 
                110                 115                 120 

Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 135 





<210>  122
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD Ze11

<400>  122
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Tyr Leu Gly Asp Lys 
                110                 115                 120 

Tyr Pro Ser Tyr Asp Leu Leu Gly Asp Thr Thr Asp Lys Leu Ile 
                125                 130                 135 

Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 145         


<210>  123
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG Ze11

<400>  123
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         


<210>  124
<211>  144
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD B23

<400>  124
Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln 
1               5                   10                  15  

Pro Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val 
                20                  25                  30  

Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser 
                35                  40                  45  

Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu 
                50                  55                  60  

Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
                65                  70                  75  

Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val 
                80                  85                  90  

Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro 
                95                  100                 105 

Ser Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ser 
                110                 115                 120 

Pro Ile Arg Gly Tyr Thr Gly Ser Asp Lys Leu Ile Phe Gly Lys 
                125                 130                 135 

Gly Thr Arg Val Thr Val Glu Pro Arg 
                140                 


<210>  125
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG B23

<400>  125
Met Val Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Asn Tyr Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130         


<210>  126
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD1 B9

<400>  126
Cys Ala Leu Gly Asn Gly Asn His Ile Gly Tyr Trp Arg Tyr Thr 
1               5                   10                  15  

Asp Lys Leu Ile Phe 
                20  


<210>  127
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG5  B9

<400>  127
Cys Ala Thr Trp Asp Arg Leu Tyr Tyr Lys Lys Leu Phe 
1               5                   10              


<210>  128
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD B9

<400>  128
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asn Gly Asn His Ile Gly 
                110                 115                 120 

Tyr Trp Arg Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg 
                125                 130                 135 

Val Thr Val Glu Pro Arg 
                140     


<210>  129
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG B9

<400>  129
Met Val Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Gly Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Arg Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Ile Asn Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Lys Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Arg Leu Tyr 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 


<210>  130
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG8 An2

<400>  130
Cys Ala Thr Trp Asp Ser Ser Lys Leu Phe 
1               5                   10  


<210>  131
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 An2

<400>  131
Cys Ala Phe Thr Gly Leu Gly Asp Thr Ser His Ala Asp Lys Leu 
1               5                   10                  15  

Ile Phe 
        


<210>  132
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG An2

<400>  132
Met Leu Leu Ala Leu Ala Leu Leu Leu Ala Phe Leu Pro Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Gly Ser Ser Ala Val Ile Thr Cys Asp Leu Pro Val 
                35                  40                  45  

Glu Asn Ala Val Tyr Thr His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Asn Ser Arg Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Arg Glu Lys Tyr His Thr Tyr Ala 
                80                  85                  90  

Ser Thr Gly Lys Ser Leu Lys Phe Ile Leu Glu Asn Leu Ile Glu 
                95                  100                 105 

Arg Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Lys 
                110                 115                 120 

Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130     


<210>  133
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD An2

<400>  133
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Phe Thr Gly Leu Gly Asp Thr Ser 
                110                 115                 120 

His Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val 
                125                 130                 135 

Glu Pro Arg 
            


<210>  134
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG3 S07

<400>  134
Cys Ala Thr Trp Asp Arg Arg Asp Tyr Lys Lys Leu Phe 
1               5                   10              


<210>  135
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 S07

<400>  135
Cys Ala Leu Gly Val Leu Pro Thr Val Thr Gly Gly Gly Leu Ile 
1               5                   10                  15  

Phe 
    


<210>  136
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG S07

<400>  136
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Arg Arg Asp 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr 
                125                 130                 


<210>  137
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD S07

<400>  137
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Val Leu Pro Thr Val Thr 
                110                 115                 120 

Gly Gly Gly Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu 
                125                 130                 135 

Pro Asn 
        


<210>  138
<211>  1900
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-eGFP_PGK-tCD34

<400>  138
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcttc accatggtga gcaagggcga                 250
ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg                 300
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc                 350
tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt                 400
gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca                 450
gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg                 500
cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa                 550
ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc                 600
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg                 650
cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga                 700
caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg                 750
aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc                 800
ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc                 850
cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg                 900
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag                 950
tactgactgg cgatggtacc ttctaccggg taggggaggc gcttttccca                 1000
aggcagtctg gagcatgcgc tttagcagcc ccgctgggca cttggcgcta                 1050
cacaagtggc ctctggcctc gcacacattc cacatccacc ggtaggcgcc                 1100
aaccggctcc gttctttggt ggccccttcg cgccaccttc tactcctccc                 1150
ctagtcagga agttcccccc cgccccgcag ctcgcgtcgt gcaggacgtg                 1200
acaaatggaa gtagcacgtc tcactagtct cgtgcagatg gacagcaccg                 1250
ctgagcaatg gaagcgggta ggcctttggg gcagcggcca atagcagctt                 1300
tgctccttcg ctttctgggc tcagaggctg ggaaggggtg ggtccggggg                 1350
cgggctcagg ggcgggctca ggggcggggc gggcgcccga aggtcctccg                 1400
gaggcccggc attctgcacg cttcaaaagc gcacgtctgc cgcgctgttc                 1450
tcctcttcct catctccggg cctttcggaa ttcaccatgg gactcgttag                 1500
aagaggcgcc agagccggac ctagaatccc tagaggatgg acagccctgt                 1550
gcctgctgtc tctgctgcct tctggcttta tggccgagct gcctacacag                 1600
ggcaccttca gcaatgtgtc caccaacgtg tccccagcca agcctacaac                 1650
aacccctgct cctagacctc ctacaccagc tcctacaatc gccagccagc                 1700
cactgtctct gaggccagaa gcttgtagac ctgctgctgg cggagccgtg                 1750
catacaagag gactggattt cgcctgcgac atctacatct gggcccctct                 1800
ggctggaaca tgtggcgttc tgctgctgag cctggtcatc accctgtact                 1850
gcaaccaccg gaacaggcgg agagtgtgca agtgccctag acctgtggtt                 1900


<210>  139
<211>  931
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-eGFP

<400>  139
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata                 50
cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa                 100
ctgtttcata cagaaggcgt cgcgaattcg cggagactct agagggtata                 150
taatggaagc tcgatttcca gcttggcatt ccggtactgt tggtaaacac                 200
caagcttcac catggtgagc aagggcgagg agctgttcac cggggtggtg                 250
cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt                 300
gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt                 350
tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc                 400
accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa                 450
gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc                 500
gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg                 550
aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga                 600
cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca                 650
acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag                 700
gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc                 750
cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc                 800
ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac                 850
gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat                 900
cactctcggc atggacgagc tgtacaagta c                                     931


<210>  140
<211>  3341
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD69-eGFP

<400>  140
atcgatttta tgatagcata gtagcccaga ccccggccta ccttaaaatt                 50
ctatatggta catttgctat tttcacacca ttatctttga gagtagtctc                 100
caaaaatgtt gtatatggat aagtctggaa ttaatttagg taaagtactc                 150
agacatggtt aagcgttata tctcatcttt aatatagctc ttcttttatt                 200
ctcttatgta ttttactttc agaaacagtc aggtttttca gagtccaagc                 250
ttgtgtgtac acaagcacta tcttttacct tcactgtctc aagtcaaaaa                 300
gaagaaaatg ccagctcaca ctttccaagc tcattttttg tgtttcagat                 350
gttccattga agaggaaagt tagaaagttc aaagacttga agaggacaga                 400
aggttggaaa gtgtttaaaa ctggaaatcc cccgtttact catggttacc                 450
ttcattgacc ctttacggta aacaattcaa aaacacaaag gcacctgcag                 500
gttaaaaata aattttacca atttgtgtaa tttgcattaa tttgagagag                 550
gatgatgtat tctaaattga agttttgatt cacaagaaga ttaaaagcca                 600
ttcagaaacc taattcaccc actgaaagga aaaaaaaaaa aagagagatg                 650
agcagtttgt ctccggaaat tgtcttaggt cggaagtctg tggtccctgt                 700
tcacatgtac ccaaaagcat cctgctgctg cagctgtctg ataagcacag                 750
agtaccccac cttctctgca cactttgcat ctagctcata ttacctcatc                 800
tttacttcct ttctgacgtc tcaccctgga ttctacatat aaggtcacac                 850
aggaaggaaa gctgcattga gttttggtgt cctgaaagac ttttgccaac                 900
cttgtccccg cactaatttc tctaagcctc ggctatacta ttttctcagc                 950
tacacgatga aatgtgaatg ataatttctg ccctaaaaat atcacttaat                 1000
tttttaacat atcatttatg aaagaagaca cataaaatgt ctccctgaag                 1050
agtgagtcgg ttaaagggag agcgagacat gcagggagat ggaaaaagaa                 1100
tcttttagag aaaaagtaaa agccctgtag tggtaggatg cttggcattt                 1150
ttaaggagga ggtttctgtc agagaggata ctgaataata ggaaaaatga                 1200
taagagaggt aaccaggggc catattatgt ataaagcatt ctcaactatt                 1250
aggtctttgg attttacggt acatttgata ggaagccttt caaagtgcag                 1300
tggggggagg agttaaacac ttcaccaaaa tcatatgaat taattataaa                 1350
acaatggttc tagctgctat gtggaaaagg gactaagaaa ttgactgaaa                 1400
aataggatgg aagcaaaggg agcttttagg gccaacatgt acctctttgt                 1450
gtcttaggta gacaaatgca tctaatggtc caactaactt ctctagatga                 1500
taacttccaa cccacctatg cataaaattt aacgtcttta ttctaaataa                 1550
gtgatattaa taataaaatt tggggcacca agattattaa tcagagtggt                 1600
attttgattt ccctccttaa atcaccatac atagctttct gcattcatct                 1650
tgcgttgact gtcattactt gtctgagtga gactgatacc acagcgatgt                 1700
tttaaataat aatcatacct caaaagactg aagtctcaga ggtatctgaa                 1750
gagaataacc tagagcacag ggggagaatt gaaggagctg ttactgaggt                 1800
gacataaaag cagtctaaat gacagtaaaa tgtgacaaga aaattagcag                 1850
gaaacaaatg aaacagataa tttaagataa acaattttag agcatagcaa                 1900
ggaagttcca gaccacaagc tttctgtttc ctgcattctt acttcttact                 1950
acgtgataca tctagtcacc agggaagaag cgaatgacac acttccaaaa                 2000
accaattcgt agctttctaa ataaaaccct ttcaagctgg agagagatcc                 2050
atgagcatag agatcttaaa attcatgttc agcaataaat cctggggccc                 2100
cagacagtgt caggtgcata gggggtgttc agtaaatatc agttaaatgt                 2150
atgcataaat cgataaacgg gattcctgga aaatactaca ctctccttct                 2200
ccaaattatc ttcatctcaa agacaggaac ctctaacttt taattcttta                 2250
cttagattat gctgtctcct aaactgttta tgttttctag aaatttaagg                 2300
caggatgtct cagagtctgg gaaaatccca ctttcctcct gctacacctt                 2350
acagttgtga gaaagcacat ttcagacaac agggaaaacc catacttcac                 2400
cacaacaaca cactatacat tgtctggtcc actggagcat aaattaaaga                 2450
gaaacaatgt agtcaagcaa gtaggcggca agaggaaggg ggcggagaca                 2500
tcatcaggga gtataaactc tgagatgcct cagagcctca cagactcaac                 2550
aagagctcca gcaaagactt tcactgtagc ttgacttgac ctgagattaa                 2600
ctagggaatc ttgaggccac catggtgagc aagggcgagg agctgttcac                 2650
cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca                 2700
agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg                 2750
accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac                 2800
cctcgtgacc accctgacct acggcgtgca gtgcttcagc cgctaccccg                 2850
accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac                 2900
gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg                 2950
cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga                 3000
agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag                 3050
tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa                 3100
cggcatcaag gtgaacttca agatccgcca caacatcgag gacggcagcg                 3150
tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc                 3200
gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa                 3250
agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg                 3300
ccgccgggat cactctcggc atggacgagc tgtacaagta c                          3341


<210>  141
<211>  1780
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGR1- eGFP

<400>  141
gtgccataga tcgaggcccg gggtcaaggc cccgcctctc ctgggcggcc                 50
cctgcccagg cgggcccagc cgctcctccc ccgcactccc ggttcgctct                 100
cacggtccct gaggtgggcg ggcgggccct ggatgacagc gatagaaccc                 150
cggcccgact cgccctcgcc cccgctctgg gtctgggctt ccccagccta                 200
gttcacgcct aggagccgcc tgagcagccg cgcgcccagc gccacacgcc                 250
acgagccctc cccgcctggg cgtccccgga tcccgcgagc gctcgggctc                 300
ccggcttgga accagggagg agggagggag cgagggagca accagctgcg                 350
acccggaaat gccatataag gagcaggaag gatcccccgc cggaacaacc                 400
cttatttggg cagcacctta tttggagtgg cccgatatgg cccggccgct                 450
tccggctctg ggaggaggga agaaggcgga gggaggggca acgcgggaac                 500
tccggagctg cgcgggtccc ggaggccccg gcggcggcta gagctctagg                 550
cttccccgaa gcctgggcgc ctgggatgcg ggcgcgggcg cgggccctag                 600
ggtgcaggat ggaggtgccg ggcgctgtcg gatggggggc ttcacgtcac                 650
tccgggtcct cccggccggt cctgccatat tagggcttcc tgcttcccat                 700
atatggccat gtacgtcacg acggaggcgg acccgtgccg ttccagaccc                 750
ttcaaataga ggcggatccg gggagtcgcg agagatccca gcgcgcagaa                 800
cttggggagc cgccgccgcc atccgccgcc gcagccagct tccgccgccg                 850
caggaccggc ccctgcccca gcctccgcag ccgcggcgcg tccacgcccg                 900
cccgcgccca gggcgagtcg gggtcgccgc ctgcacgctt ctcagtgttc                 950
cccgcgcccc gcatgtaacc cggccaggcc cccgcaactg tgtcccctgc                 1000
agctccagcc ccgggctgca cccccccgcc ccgacaccag ctctccagcc                 1050
tgctcgtcca atggtgagca agggcgagga gctgttcacc ggggtggtgc                 1100
ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg                 1150
tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt                 1200
catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca                 1250
ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag                 1300
cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg                 1350
caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga                 1400
agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac                 1450
ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa                 1500
cagccacaac gtctatatca tggccgacaa gcagaagaac ggcatcaagg                 1550
tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc                 1600
gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc                 1650
cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg                 1700
agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc                 1750
actctcggca tggacgagct gtacaagtac                                       1780


<210>  142
<211>  1364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNy- eGFP

<400>  142
atgcttgtat tgtatttcta ctgggcagtg ctgatctaga gcaatttgaa                 50
acttgtggta gatattttac taaccaactc tgatgaagga cttcctcacc                 100
aaattgttct tttaaccgca ttctttcctt gctttctggt catttgcaag                 150
aaaaatttta aaaggctgcc cctttgtaaa ggtttgagag gccctagaat                 200
ttcgtttttc acttgttccc aaccacaagc aaatgatcaa tgtgctttgt                 250
gaatgaagag tcaacatttt accagggcga agtggggagg tacaaaaaaa                 300
tttccagtcc ttgaatggtg tgaagtaaaa gtgccttcaa agaatcccac                 350
cagaatggca caggtgggca taatgggtct gtctcatcgt caaaggaccc                 400
aaggagtcta aaggaaactc taactacaac acccaaatgc cacaaaacct                 450
tagttattaa tacaaactat catccctgcc tatctgtcac catctcatct                 500
taaaaaactt gtgaaaatac gtaatcctca ggagacttca attaggtata                 550
aataccagca gccagaggag gtgcagcaca ttgttctgat catctgaaga                 600
tcagctatta gaagagaaag atcagttaag tcctttgggc caccatggtg                 650
agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct                 700
ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg                 750
gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc                 800
aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt                 850
gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca                 900
agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag                 950
gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac                 1000
cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca                 1050
acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat                 1100
atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg                 1150
ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga                 1200
acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg                 1250
agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat                 1300
ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg                 1350
agctgtacaa gtac                                                        1364


<210>  143
<211>  1114
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IL2-eGFP

<400>  143
agttttatga caaagaaaat tttctgagtt acttttgtat ccccaccccc                 50
ttaaagaaag gaggaaaaac tgtttcatac agaaggcgtt aattgcatga                 100
attagagcta tcacctaagt gtgggctaat gtaacaaaga gggatttcac                 150
ctacatccat tcagtcagtc tttgggggtt taaagaaatt ccaaagagtc                 200
atcagaagag gaaaaatgaa ggtaatgttt tttcagacag gtaaagtctt                 250
tgaaaatatg tgtaatatgt aaaacatttt gacaccccca taatattttt                 300
ccagaattaa cagtataaat tgcatctctt gttcaagagt tccctatcac                 350
tctctttaat cactactcac agtaacctca actcctgcgc caccatggtg                 400
agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct                 450
ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg                 500
gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc                 550
aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt                 600
gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca                 650
agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag                 700
gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac                 750
cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca                 800
acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat                 850
atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg                 900
ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga                 950
acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg                 1000
agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat                 1050
ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg                 1100
agctgtacaa gtac                                                        1114


<210>  144
<211>  3239
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-eGFP single vector

<400>  144
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata                 50
cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa                 100
ctgtttcata cagaaggcgt cgcgaattcg cggagactct agagggtata                 150
taatggaagc tcgatttcca gcttggcatt ccggtactgt tggtaaacac                 200
caagcttcac catggtgagc aagggcgagg agctgttcac cggggtggtg                 250
cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt                 300
gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt                 350
tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc                 400
accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa                 450
gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc                 500
gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg                 550
aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga                 600
cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca                 650
acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag                 700
gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc                 750
cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc                 800
ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac                 850
gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat                 900
cactctcggc atggacgagc tgtacaagta cctgacgatg catgctgaaa                 950
gaccccacct gtaggtttgg caagctagct taagtaacgc cattttgcaa                 1000
ggcatggaaa atacataact gagaatagag aagttcagat caaggttagg                 1050
aacagagaga cagcagaata tgggccaaac aggatatctg tggtaagcag                 1100
ttcctgcccc ggctcagggc caagaacaga tggtccccag atgcggtccc                 1150
gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag                 1200
gacctgaaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt                 1250
ctcgcttctg ttcgcgcgtt tctgctcccc gagctcaata aaagagccca                 1300
caacccctca ctagcggccc taatacgact cactatagcc cggctcgagg                 1350
ctaggcgcga attcgccacc atggtgtccc tgctgcacgc cagcaccctg                 1400
gccgtgctgg gcgccctgtg cgtgtatggc gccggacacc tggaacagcc                 1450
ccagatcagc agcaccaaga ccctgagcaa gaccgccagg ctggaatgcg                 1500
tggtgtccgg catcaccatc agcgccacct ccgtgtactg gtacagagag                 1550
agacccggcg aggtcatcca gttcctggtg tccatcagct acgacggcac                 1600
cgtgcggaaa gagagcggca tccccagcgg caagttcgag gtggacagaa                 1650
tccccgagac cagcacctcc accctgacca tccacaacgt ggagaagcag                 1700
gacatcgcca cctactactg cgccctgtgg gagatccagg aactgggcaa                 1750
gaaaatcaag gtgttcggcc ctggcaccaa gctgatcatc accgacaagc                 1800
agctggacgc cgacgtgagc cccaagccta ccatcttcct gcccagcatc                 1850
gccgagacca agctgcagaa ggccggcacc tacctgtgcc tgctggaaaa                 1900
gttcttcccc gacgtgatca agatccactg ggaggaaaag aagagcaaca                 1950
ccatcctggg cagccaggaa ggcaatacca tgaaaaccaa cgacacctac                 2000
atgaagttca gctggctgac cgtgcccgag aagagcctgg acaaagagca                 2050
cagatgcatc gtccggcacg agaacaacaa gaacggcgtg gaccaggaaa                 2100
tcatcttccc ccccatcaag accgatgtga tcacaatgga ccccaaggac                 2150
aactgcagca aggacgccaa cgataccctg ctgctgcagc tgaccaacac                 2200
cagcgcctac tacatgtatc tcctgctgct gctgaagagc gtggtgtact                 2250
tcgccatcat cacctgctgt ctcctgaggc ggaccgcctt ctgctgcaac                 2300
ggcgagaaga gcgaaggccg cggcagcctg ctgacctgcg gagacgtgga                 2350
agaaaaccct ggcccgatgg agcggatcag cagcctgatc cacctgagcc                 2400
tgttctgggc cggagtgatg agcgccatcg agctggtgcc cgagcaccag                 2450
accgtgcccg tgagcatcgg cgtgcccgcc accctgcggt gcagcatgaa                 2500
gggcgaggcc atcggcaact actacatcaa ctggtacaga aagacccagg                 2550
gcaacaccat gaccttcatc taccgggaga aggacatcta cggccctggc                 2600
ttcaaggaca acttccaggg cgacatcgac atcgccaaga acctggccgt                 2650
gctgaagatc ctggccccca gcgagaggga cgagggcagc tactactgcg                 2700
cctgcgacgc cctgaagaga accgacaccg acaagctgat cttcggcaag                 2750
ggcacccggg tgaccgtgga gcccagaagc cagccccaca ccaagcccag                 2800
cgtgttcgtg atgaagaacg gcaccaacgt ggcctgcctg gtgaaagagt                 2850
tctaccccaa ggacatccgg atcaacctgg tgtccagcaa gaagatcacc                 2900
gagttcgacc ccgccatcgt gatcagcccc agcggcaagt acaacgccgt                 2950
gaagctgggc aagtacgagg acagcaacag cgtgacctgc agcgtgcagc                 3000
acgacaacaa gaccgtgcac agcaccgact tcgaggtgaa aaccgactcc                 3050
accgaccacg tgaagcccaa agagaccgag aacaccaagc agcccagcaa                 3100
gagctgccac aagcccaagg ccatcgtgca caccgagaag gtgaacatga                 3150
tgagcctgac cgtgctgggc ctgcggatgc tgttcgccaa gacagtggcc                 3200
gtgaacttcc tgctgaccgc caagctgttc ttcctgtga                             3239


<210>  145
<211>  3389
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-LUC-TdTomato

<400>  145
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcgcc accatggagg acgccaagaa                 250
catcaagaag ggccctgcac ctttctaccc cttggaggac ggcaccgccg                 300
gagagcagct gcacaaggcc atgaagaggt acgccttggt gcctggcacc                 350
atcgccttca ccgacgccca catcgaggtg gacatcacct acgccgagta                 400
cttcgagatg agcgtgaggt tggccgaggc catgaagcgg tacggcctga                 450
acaccaacca ccggatcgtg gtgtgcagcg agaacagcct gcaattcttc                 500
atgcctgtcc tcggagcctt gttcatcggc gttgccgtgg ctcctgccaa                 550
cgacatctac aacgagcggg agctgctgaa cagcatgggc atcagccagc                 600
ctaccgtggt gttcgtgagc aagaagggcc tccagaagat cctgaacgtg                 650
cagaagaagc tgcctatcat ccagaagatc atcatcatgg acagcaagac                 700
cgactaccag ggcttccaga gcatgtacac cttcgtcacc agccacctgc                 750
ctcctggctt caacgagtac gacttcgtgc ctgagagctt cgacagggac                 800
aagacaatcg ctctgatcat gaacagcagc ggcagcaccg gcctgcctaa                 850
gggcgttgcc ctgcctcaca ggaccgcctg cgtgaggttc agccacgcta                 900
gagaccctat cttcggcaac cagatcatcc ctgacaccgc tatcctgagc                 950
gtcgtgcctt tccaccacgg ctttggcatg ttcaccaccc tgggctacct                 1000
gatctgtggc ttcagggtgg tgctgatgta caggttcgag gaggagctgt                 1050
tcctgcggag cctgcaggac tacaagatcc agagcgcact gctggtgcct                 1100
accctgttca gcttcttcgc caagagcacc ctgatcgaca agtacgacct                 1150
gagcaacctg cacgagatcg ccagcggcgg agctcctctg agcaaggagg                 1200
tcggcgaggc cgtcgccaag aggttccacc tgcctggcat ccggcagggc                 1250
tacggcctga ccgagaccac cagcgccatc ctgatcacac ctgagggcga                 1300
cgacaagcct ggcgctgtgg gcaaggtcgt gccattcttc gaggccaagg                 1350
ttgtggacct ggacaccggc aagaccctgg gagtgaacca gagaggcgag                 1400
ctgtgcgtga gaggccctat gatcatgagc ggctacgtga acaaccctga                 1450
ggccaccaac gctctgatcg acaaggacgg atggctgcac agcggcgaca                 1500
tcgcctactg ggacgaggac gagcacttct tcatcgtgga ccggctgaag                 1550
agcctgatca agtacaaagg ctaccaggtc gcccctgccg agctggagag                 1600
catcctgctg cagcacccta acatcttcga cgccggcgtg gctggcctgc                 1650
ctgacgacga cgctggcgag ctgccagctg ctgtcgtggt gctggagcac                 1700
ggcaagacca tgaccgagaa ggagatcgtg gactacgtgg ccagccaggt                 1750
gaccaccgcc aagaagctga gaggcggcgt tgtgttcgtc gacgaggtgc                 1800
ctaagggcct gaccggcaag ctggacgctc ggaagatcag agagatcctg                 1850
atcaaggcca agaagggagg aaagatcgcc gtgaggagga agcggagcgg                 1900
atccggagaa ggaaggggaa gcctcctgac atgcggagac gtcgaggaaa                 1950
atcctggacc catggtgagc aagggcgagg aggtgatcaa ggagttcatg                 2000
cggttcaagg tgcggatgga gggcagcatg aacggccacg agttcgagat                 2050
cgagggtgag ggagagggcc ggccctacga gggcacccag accgccaagt                 2100
tgaaggtgac caagggcggc cccttgccct tcgcctggga catcttgagc                 2150
ccccagttca tgtacggcag caaggcctac gtgaagcacc ccgccgacat                 2200
ccccgactac aagaagttga gcttccccga gggcttcaag tgggagcggg                 2250
tgatgaactt cgaggacggc ggcttggtga ccgtgaccca ggacagcagc                 2300
ttgcaggacg gcaccttgat ctacaaggtg aagatgcggg gcaccaactt                 2350
cccccccgac ggccccgtga tgcagaagaa gacaatgggc tgggaggcca                 2400
gcaccgagcg gttgtacccc cgggacggcg tgttgaaggg cgagatccac                 2450
caggccttga agttgaagga cggcggccac tacctggtgg agttcaagac                 2500
catctacatg gctaagaagc ccgtgcagtt gcccggctac tactacgtgg                 2550
acaccaagtt ggacatcacc agccacaacg aggactacac catcgtggag                 2600
cagtacgagc ggagcgaggg ccggcaccac ttgttcttgg gccacggcac                 2650
cggcagcacc ggcagcggca gcagcggcac cgccagcagc gaggacaaca                 2700
acatggccgt cattaaagaa tttatgagat ttaaagtcag aatggaaggg                 2750
tctatgaatg gacatgaatt tgaaattgaa ggagaaggag aagggagacc                 2800
ttatgaagga acacaaacag ctaaactcaa agtcacaaaa ggaggacctc                 2850
tcccttttgc ttgggatatt ctctctcctc aatttatgta tggatctaaa                 2900
gcttatgtca aacatcctgc tgatattcct gattataaaa aactctcttt                 2950
tcctgaaggg tttaaatggg aaagagtcat gaattttgaa gatggaggac                 3000
tcgtcacagt cacacaagat tcttctctcc aagatgggac actcatttat                 3050
aaagtcaaaa tgagagggac aaattttcct cctgatggac ctgtcatgca                 3100
aaaaaaaaca atggggtggg aagcttccac agaaagactc tatcctagag                 3150
atggagtcct caaaggagaa attcatcaag ctctcaaact caaagatgga                 3200
ggacattatc tcgtcgaatt taaaacaatt tatatggcta aaaaacctgt                 3250
ccaactccct gggtattatt atgtcgatac aaaactcgat attacatctc                 3300
ataatgaaga ttatacaatt gtcgaacaat atgaaagatc tgaagggagg                 3350
catcatctct ttctctacgg catggacgag ctgtacaag                             3389


<210>  146
<211>  2678
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-eGFP-LUC

<400>  146
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcttc accatggagg acgccaagaa                 250
catcaagaag ggccctgcac ctttctaccc cttggaggac ggcaccgccg                 300
gagagcagct gcacaaggcc atgaagaggt acgccttggt gcctggcacc                 350
atcgccttca ccgacgccca catcgaggtg gacatcacct acgccgagta                 400
cttcgagatg agcgtgaggt tggccgaggc catgaagcgg tacggcctga                 450
acaccaacca ccggatcgtg gtgtgcagcg agaacagcct gcaattcttc                 500
atgcctgtcc tcggagcctt gttcatcggc gttgccgtgg ctcctgccaa                 550
cgacatctac aacgagcggg agctgctgaa cagcatgggc atcagccagc                 600
ctaccgtggt gttcgtgagc aagaagggcc tccagaagat cctgaacgtg                 650
cagaagaagc tgcctatcat ccagaagatc atcatcatgg acagcaagac                 700
cgactaccag ggcttccaga gcatgtacac cttcgtcacc agccacctgc                 750
ctcctggctt caacgagtac gacttcgtgc ctgagagctt cgacagggac                 800
aagacaatcg ctctgatcat gaacagcagc ggcagcaccg gcctgcctaa                 850
gggcgttgcc ctgcctcaca ggaccgcctg cgtgaggttc agccacgcta                 900
gagaccctat cttcggcaac cagatcatcc ctgacaccgc tatcctgagc                 950
gtcgtgcctt tccaccacgg ctttggcatg ttcaccaccc tgggctacct                 1000
gatctgtggc ttcagggtgg tgctgatgta caggttcgag gaggagctgt                 1050
tcctgcggag cctgcaggac tacaagatcc agagcgcact gctggtgcct                 1100
accctgttca gcttcttcgc caagagcacc ctgatcgaca agtacgacct                 1150
gagcaacctg cacgagatcg ccagcggcgg agctcctctg agcaaggagg                 1200
tcggcgaggc cgtcgccaag aggttccacc tgcctggcat ccggcagggc                 1250
tacggcctga ccgagaccac cagcgccatc ctgatcacac ctgagggcga                 1300
cgacaagcct ggcgctgtgg gcaaggtcgt gccattcttc gaggccaagg                 1350
ttgtggacct ggacaccggc aagaccctgg gagtgaacca gagaggcgag                 1400
ctgtgcgtga gaggccctat gatcatgagc ggctacgtga acaaccctga                 1450
ggccaccaac gctctgatcg acaaggacgg atggctgcac agcggcgaca                 1500
tcgcctactg ggacgaggac gagcacttct tcatcgtgga ccggctgaag                 1550
agcctgatca agtacaaagg ctaccaggtc gcccctgccg agctggagag                 1600
catcctgctg cagcacccta acatcttcga cgccggcgtg gctggcctgc                 1650
ctgacgacga cgctggcgag ctgccagctg ctgtcgtggt gctggagcac                 1700
ggcaagacca tgaccgagaa ggagatcgtg gactacgtgg ccagccaggt                 1750
gaccaccgcc aagaagctga gaggcggcgt tgtgttcgtc gacgaggtgc                 1800
ctaagggcct gaccggcaag ctggacgctc ggaagatcag agagatcctg                 1850
atcaaggcca agaagggagg aaagatcgcc gtgaggagga agcggagcgg                 1900
atccggagaa ggaaggggaa gcctcctgac atgcggagac gtcgaggaaa                 1950
atcctggacc catggtgagc aagggcgagg agctgttcac cggggtggtg                 2000
cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt                 2050
gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt                 2100
tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc                 2150
accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa                 2200
gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc                 2250
gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg                 2300
aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga                 2350
cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca                 2400
acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag                 2450
gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc                 2500
cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc                 2550
ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac                 2600
gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat                 2650
cactctcggc atggacgagc tgtacaag                                         2678


<210>  147
<211>  2678
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-LUC-eGFP

<400>  147
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcgcc accatggtga gcaagggcga                 250
ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg                 300
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc                 350
tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt                 400
gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca                 450
gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg                 500
cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa                 550
ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc                 600
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg                 650
cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga                 700
caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg                 750
aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc                 800
ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc                 850
cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg                 900
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag                 950
ggcagcggcg aaggccgcgg cagcctgctg acctgcggcg atgtggaaga                 1000
aaaccctggg cccatggagg acgccaagaa catcaagaag ggccctgcac                 1050
ctttctaccc cttggaggac ggcaccgccg gagagcagct gcacaaggcc                 1100
atgaagaggt acgccttggt gcctggcacc atcgccttca ccgacgccca                 1150
catcgaggtg gacatcacct acgccgagta cttcgagatg agcgtgaggt                 1200
tggccgaggc catgaagcgg tacggcctga acaccaacca ccggatcgtg                 1250
gtgtgcagcg agaacagcct gcaattcttc atgcctgtcc tcggagcctt                 1300
gttcatcggc gttgccgtgg ctcctgccaa cgacatctac aacgagcggg                 1350
agctgctgaa cagcatgggc atcagccagc ctaccgtggt gttcgtgagc                 1400
aagaagggcc tccagaagat cctgaacgtg cagaagaagc tgcctatcat                 1450
ccagaagatc atcatcatgg acagcaagac cgactaccag ggcttccaga                 1500
gcatgtacac cttcgtcacc agccacctgc ctcctggctt caacgagtac                 1550
gacttcgtgc ctgagagctt cgacagggac aagacaatcg ctctgatcat                 1600
gaacagcagc ggcagcaccg gcctgcctaa gggcgttgcc ctgcctcaca                 1650
ggaccgcctg cgtgaggttc agccacgcta gagaccctat cttcggcaac                 1700
cagatcatcc ctgacaccgc tatcctgagc gtcgtgcctt tccaccacgg                 1750
ctttggcatg ttcaccaccc tgggctacct gatctgtggc ttcagggtgg                 1800
tgctgatgta caggttcgag gaggagctgt tcctgcggag cctgcaggac                 1850
tacaagatcc agagcgcact gctggtgcct accctgttca gcttcttcgc                 1900
caagagcacc ctgatcgaca agtacgacct gagcaacctg cacgagatcg                 1950
ccagcggcgg agctcctctg agcaaggagg tcggcgaggc cgtcgccaag                 2000
aggttccacc tgcctggcat ccggcagggc tacggcctga ccgagaccac                 2050
cagcgccatc ctgatcacac ctgagggcga cgacaagcct ggcgctgtgg                 2100
gcaaggtcgt gccattcttc gaggccaagg ttgtggacct ggacaccggc                 2150
aagaccctgg gagtgaacca gagaggcgag ctgtgcgtga gaggccctat                 2200
gatcatgagc ggctacgtga acaaccctga ggccaccaac gctctgatcg                 2250
acaaggacgg atggctgcac agcggcgaca tcgcctactg ggacgaggac                 2300
gagcacttct tcatcgtgga ccggctgaag agcctgatca agtacaaagg                 2350
ctaccaggtc gcccctgccg agctggagag catcctgctg cagcacccta                 2400
acatcttcga cgccggcgtg gctggcctgc ctgacgacga cgctggcgag                 2450
ctgccagctg ctgtcgtggt gctggagcac ggcaagacca tgaccgagaa                 2500
ggagatcgtg gactacgtgg ccagccaggt gaccaccgcc aagaagctga                 2550
gaggcggcgt tgtgttcgtc gacgaggtgc ctaagggcct gaccggcaag                 2600
ctggacgctc ggaagatcag agagatcctg atcaaggcca agaagggagg                 2650
aaagatcgcc gtgaggagga agcggtga                                         2678


<210>  148
<211>  3610
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-LUC-eGFP_PGK-tCD34

<400>  148
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcgcc accatggtga gcaagggcga                 250
ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg                 300
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc                 350
tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt                 400
gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca                 450
gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg                 500
cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa                 550
ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc                 600
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg                 650
cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga                 700
caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg                 750
aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc                 800
ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc                 850
cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg                 900
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag                 950
ggcagcggcg aaggccgcgg cagcctgctg acctgcggcg atgtggaaga                 1000
aaaccctggg cccatggagg acgccaagaa catcaagaag ggccctgcac                 1050
ctttctaccc cttggaggac ggcaccgccg gagagcagct gcacaaggcc                 1100
atgaagaggt acgccttggt gcctggcacc atcgccttca ccgacgccca                 1150
catcgaggtg gacatcacct acgccgagta cttcgagatg agcgtgaggt                 1200
tggccgaggc catgaagcgg tacggcctga acaccaacca ccggatcgtg                 1250
gtgtgcagcg agaacagcct gcaattcttc atgcctgtcc tcggagcctt                 1300
gttcatcggc gttgccgtgg ctcctgccaa cgacatctac aacgagcggg                 1350
agctgctgaa cagcatgggc atcagccagc ctaccgtggt gttcgtgagc                 1400
aagaagggcc tccagaagat cctgaacgtg cagaagaagc tgcctatcat                 1450
ccagaagatc atcatcatgg acagcaagac cgactaccag ggcttccaga                 1500
gcatgtacac cttcgtcacc agccacctgc ctcctggctt caacgagtac                 1550
gacttcgtgc ctgagagctt cgacagggac aagacaatcg ctctgatcat                 1600
gaacagcagc ggcagcaccg gcctgcctaa gggcgttgcc ctgcctcaca                 1650
ggaccgcctg cgtgaggttc agccacgcta gagaccctat cttcggcaac                 1700
cagatcatcc ctgacaccgc tatcctgagc gtcgtgcctt tccaccacgg                 1750
ctttggcatg ttcaccaccc tgggctacct gatctgtggc ttcagggtgg                 1800
tgctgatgta caggttcgag gaggagctgt tcctgcggag cctgcaggac                 1850
tacaagatcc agagcgcact gctggtgcct accctgttca gcttcttcgc                 1900
caagagcacc ctgatcgaca agtacgacct gagcaacctg cacgagatcg                 1950
ccagcggcgg agctcctctg agcaaggagg tcggcgaggc cgtcgccaag                 2000
aggttccacc tgcctggcat ccggcagggc tacggcctga ccgagaccac                 2050
cagcgccatc ctgatcacac ctgagggcga cgacaagcct ggcgctgtgg                 2100
gcaaggtcgt gccattcttc gaggccaagg ttgtggacct ggacaccggc                 2150
aagaccctgg gagtgaacca gagaggcgag ctgtgcgtga gaggccctat                 2200
gatcatgagc ggctacgtga acaaccctga ggccaccaac gctctgatcg                 2250
acaaggacgg atggctgcac agcggcgaca tcgcctactg ggacgaggac                 2300
gagcacttct tcatcgtgga ccggctgaag agcctgatca agtacaaagg                 2350
ctaccaggtc gcccctgccg agctggagag catcctgctg cagcacccta                 2400
acatcttcga cgccggcgtg gctggcctgc ctgacgacga cgctggcgag                 2450
ctgccagctg ctgtcgtggt gctggagcac ggcaagacca tgaccgagaa                 2500
ggagatcgtg gactacgtgg ccagccaggt gaccaccgcc aagaagctga                 2550
gaggcggcgt tgtgttcgtc gacgaggtgc ctaagggcct gaccggcaag                 2600
ctggacgctc ggaagatcag agagatcctg atcaaggcca agaagggagg                 2650
aaagatcgcc gtgaggagga agcggtgaca ggatccaggg taggggaggc                 2700
gcttttccca aggcagtctg gagcatgcgc tttagcagcc ccgctgggca                 2750
cttggcgcta cacaagtggc ctctggcctc gcacacattc cacatccacc                 2800
ggtaggcgcc aaccggctcc gttctttggt ggccccttcg cgccaccttc                 2850
tactcctccc ctagtcagga agttcccccc cgccccgcag ctcgcgtcgt                 2900
gcaggacgtg acaaatggaa gtagcacgtc tcactagtct cgtgcagatg                 2950
gacagcaccg ctgagcaatg gaagcgggta ggcctttggg gcagcggcca                 3000
atagcagctt tgctccttcg ctttctgggc tcagaggctg ggaaggggtg                 3050
ggtccggggg cgggctcagg ggcgggctca ggggcggggc gggcgcccga                 3100
aggtcctccg gaggcccggc attctgcacg cttcaaaagc gcacgtctgc                 3150
cgcgctgttc tcctcttcct catctccggg cctttcggaa ttcaccatgg                 3200
gactcgttag aagaggcgcc agagccggac ctagaatccc tagaggatgg                 3250
acagccctgt gcctgctgtc tctgctgcct tctggcttta tggccgagct                 3300
gcctacacag ggcaccttca gcaatgtgtc caccaacgtg tccccagcca                 3350
agcctacaac aacccctgct cctagacctc ctacaccagc tcctacaatc                 3400
gccagccagc cactgtctct gaggccagaa gcttgtagac ctgctgctgg                 3450
cggagccgtg catacaagag gactggattt cgcctgcgac atctacatct                 3500
gggcccctct ggctggaaca tgtggcgttc tgctgctgag cctggtcatc                 3550
accctgtact gcaaccaccg gaacaggcgg agagtgtgca agtgccctag                 3600
acctgtggtt                                                             3610


<210>  149
<211>  4191
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT-LUC single vector

<400>  149
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcgcc accatggagg acgccaagaa                 250
catcaagaag ggccctgcac ctttctaccc cttggaggac ggcaccgccg                 300
gagagcagct gcacaaggcc atgaagaggt acgccttggt gcctggcacc                 350
atcgccttca ccgacgccca catcgaggtg gacatcacct acgccgagta                 400
cttcgagatg agcgtgaggt tggccgaggc catgaagcgg tacggcctga                 450
acaccaacca ccggatcgtg gtgtgcagcg agaacagcct gcaattcttc                 500
atgcctgtcc tcggagcctt gttcatcggc gttgccgtgg ctcctgccaa                 550
cgacatctac aacgagcggg agctgctgaa cagcatgggc atcagccagc                 600
ctaccgtggt gttcgtgagc aagaagggcc tccagaagat cctgaacgtg                 650
cagaagaagc tgcctatcat ccagaagatc atcatcatgg acagcaagac                 700
cgactaccag ggcttccaga gcatgtacac cttcgtcacc agccacctgc                 750
ctcctggctt caacgagtac gacttcgtgc ctgagagctt cgacagggac                 800
aagacaatcg ctctgatcat gaacagcagc ggcagcaccg gcctgcctaa                 850
gggcgttgcc ctgcctcaca ggaccgcctg cgtgaggttc agccacgcta                 900
gagaccctat cttcggcaac cagatcatcc ctgacaccgc tatcctgagc                 950
gtcgtgcctt tccaccacgg ctttggcatg ttcaccaccc tgggctacct                 1000
gatctgtggc ttcagggtgg tgctgatgta caggttcgag gaggagctgt                 1050
tcctgcggag cctgcaggac tacaagatcc agagcgcact gctggtgcct                 1100
accctgttca gcttcttcgc caagagcacc ctgatcgaca agtacgacct                 1150
gagcaacctg cacgagatcg ccagcggcgg agctcctctg agcaaggagg                 1200
tcggcgaggc cgtcgccaag aggttccacc tgcctggcat ccggcagggc                 1250
tacggcctga ccgagaccac cagcgccatc ctgatcacac ctgagggcga                 1300
cgacaagcct ggcgctgtgg gcaaggtcgt gccattcttc gaggccaagg                 1350
ttgtggacct ggacaccggc aagaccctgg gagtgaacca gagaggcgag                 1400
ctgtgcgtga gaggccctat gatcatgagc ggctacgtga acaaccctga                 1450
ggccaccaac gctctgatcg acaaggacgg atggctgcac agcggcgaca                 1500
tcgcctactg ggacgaggac gagcacttct tcatcgtgga ccggctgaag                 1550
agcctgatca agtacaaagg ctaccaggtc gcccctgccg agctggagag                 1600
catcctgctg cagcacccta acatcttcga cgccggcgtg gctggcctgc                 1650
ctgacgacga cgctggcgag ctgccagctg ctgtcgtggt gctggagcac                 1700
ggcaagacca tgaccgagaa ggagatcgtg gactacgtgg ccagccaggt                 1750
gaccaccgcc aagaagctga gaggcggcgt tgtgttcgtc gacgaggtgc                 1800
ctaagggcct gaccggcaag ctggacgctc ggaagatcag agagatcctg                 1850
atcaaggcca agaagggagg aaagatcgcc gtgctgacga tgcatgctga                 1900
aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc                 1950
aaggcatgga aaatacataa ctgagaatag agaagttcag atcaaggtta                 2000
ggaacagaga gacagcagaa tatgggccaa acaggatatc tgtggtaagc                 2050
agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc                 2100
ccgccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca                 2150
aggacctgaa aatgaccctg tgccttattt gaactaacca atcagttcgc                 2200
ttctcgcttc tgttcgcgcg tttctgctcc ccgagctcaa taaaagagcc                 2250
cacaacccct cactagcggc cctaatacga ctcactatag cccggctcga                 2300
ggctaggcgc gaattcgcca ccatggtgtc cctgctgcac gccagcaccc                 2350
tggccgtgct gggcgccctg tgcgtgtatg gcgccggaca cctggaacag                 2400
ccccagatca gcagcaccaa gaccctgagc aagaccgcca ggctggaatg                 2450
cgtggtgtcc ggcatcacca tcagcgccac ctccgtgtac tggtacagag                 2500
agagacccgg cgaggtcatc cagttcctgg tgtccatcag ctacgacggc                 2550
accgtgcgga aagagagcgg catccccagc ggcaagttcg aggtggacag                 2600
aatccccgag accagcacct ccaccctgac catccacaac gtggagaagc                 2650
aggacatcgc cacctactac tgcgccctgt gggagatcca ggaactgggc                 2700
aagaaaatca aggtgttcgg ccctggcacc aagctgatca tcaccgacaa                 2750
gcagctggac gccgacgtga gccccaagcc taccatcttc ctgcccagca                 2800
tcgccgagac caagctgcag aaggccggca cctacctgtg cctgctggaa                 2850
aagttcttcc ccgacgtgat caagatccac tgggaggaaa agaagagcaa                 2900
caccatcctg ggcagccagg aaggcaatac catgaaaacc aacgacacct                 2950
acatgaagtt cagctggctg accgtgcccg agaagagcct ggacaaagag                 3000
cacagatgca tcgtccggca cgagaacaac aagaacggcg tggaccagga                 3050
aatcatcttc ccccccatca agaccgatgt gatcacaatg gaccccaagg                 3100
acaactgcag caaggacgcc aacgataccc tgctgctgca gctgaccaac                 3150
accagcgcct actacatgta tctcctgctg ctgctgaaga gcgtggtgta                 3200
cttcgccatc atcacctgct gtctcctgag gcggaccgcc ttctgctgca                 3250
acggcgagaa gagcgaaggc cgcggcagcc tgctgacctg cggagacgtg                 3300
gaagaaaacc ctggcccgat ggagcggatc agcagcctga tccacctgag                 3350
cctgttctgg gccggagtga tgagcgccat cgagctggtg cccgagcacc                 3400
agaccgtgcc cgtgagcatc ggcgtgcccg ccaccctgcg gtgcagcatg                 3450
aagggcgagg ccatcggcaa ctactacatc aactggtaca gaaagaccca                 3500
gggcaacacc atgaccttca tctaccggga gaaggacatc tacggccctg                 3550
gcttcaagga caacttccag ggcgacatcg acatcgccaa gaacctggcc                 3600
gtgctgaaga tcctggcccc cagcgagagg gacgagggca gctactactg                 3650
cgcctgcgac gccctgaaga gaaccgacac cgacaagctg atcttcggca                 3700
agggcacccg ggtgaccgtg gagcccagaa gccagcccca caccaagccc                 3750
agcgtgttcg tgatgaagaa cggcaccaac gtggcctgcc tggtgaaaga                 3800
gttctacccc aaggacatcc ggatcaacct ggtgtccagc aagaagatca                 3850
ccgagttcga ccccgccatc gtgatcagcc ccagcggcaa gtacaacgcc                 3900
gtgaagctgg gcaagtacga ggacagcaac agcgtgacct gcagcgtgca                 3950
gcacgacaac aagaccgtgc acagcaccga cttcgaggtg aaaaccgact                 4000
ccaccgacca cgtgaagccc aaagagaccg agaacaccaa gcagcccagc                 4050
aagagctgcc acaagcccaa ggccatcgtg cacaccgaga aggtgaacat                 4100
gatgagcctg accgtgctgg gcctgcggat gctgttcgcc aagacagtgg                 4150
ccgtgaactt cctgctgacc gccaagctgt tcttcctgtg a                          4191


<210>  150
<211>  153
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRDC

<400>  150
Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly 
1               5                   10                  15  

Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile 
                20                  25                  30  

Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro 
                35                  40                  45  

Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu 
                50                  55                  60  

Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln His 
                65                  70                  75  

Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr Asp 
                80                  85                  90  

Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln 
                95                  100                 105 

Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
                110                 115                 120 

Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu 
                125                 130                 135 

Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu 
                140                 145                 150 

Phe Phe Leu 
            


<210>  151
<211>  173
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRGC1

<400>  151
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
                110                 115                 120 

Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
                125                 130                 135 

Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val 
                140                 145                 150 

Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala 
                155                 160                 165 

Phe Cys Cys Asn Gly Glu Lys Ser 
                170             


<210>  152
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRGC2

<400>  152
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn 
                110                 115                 120 

Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp 
                125                 130                 135 

Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr 
                140                 145                 150 

Asn Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser 
                155                 160                 165 

Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr 
                170                 175                 180 

Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                185                 


<210>  153
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT response element

<400>  153
wggaaa                                                                 6  


<210>  154
<211>  550
<212>  PRT
<213>  Photinus pyralis

<220>
<223>  Luciferase of Photinus pyralis - GenBank AAA29795.1

<400>  154
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr 
1               5                   10                  15  

Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met 
                20                  25                  30  

Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala 
                35                  40                  45  

His Ile Glu Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser 
                50                  55                  60  

Val Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn 
                65                  70                  75  

His Arg Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe Met 
                80                  85                  90  

Pro Val Leu Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala 
                95                  100                 105 

Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met Asn Ile 
                110                 115                 120 

Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys Gly Leu Gln Lys 
                125                 130                 135 

Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile 
                140                 145                 150 

Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser Met Tyr 
                155                 160                 165 

Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr Asp 
                170                 175                 180 

Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile 
                185                 190                 195 

Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu 
                200                 205                 210 

Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro 
                215                 220                 225 

Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
                230                 235                 240 

Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr 
                245                 250                 255 

Leu Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu 
                260                 265                 270 

Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala 
                275                 280                 285 

Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu 
                290                 295                 300 

Ile Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly 
                305                 310                 315 

Gly Ala Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg 
                320                 325                 330 

Phe His Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr 
                335                 340                 345 

Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly 
                350                 355                 360 

Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala Lys Val Val Asp 
                365                 370                 375 

Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg Gly Glu Leu 
                380                 385                 390 

Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn Asn Pro 
                395                 400                 405 

Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His Ser 
                410                 415                 420 

Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val 
                425                 430                 435 

Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala 
                440                 445                 450 

Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe 
                455                 460                 465 

Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
                470                 475                 480 

Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu 
                485                 490                 495 

Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys 
                500                 505                 510 

Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly 
                515                 520                 525 

Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile 
                530                 535                 540 

Lys Ala Lys Lys Gly Gly Lys Ser Lys Leu 
                545                 550 


<210>  155
<211>  545
<212>  PRT
<213>  Photuris pensylvanica

<220>
<223>  Luciferase of Photuris pensylvanica - GenBank AAB60897.1

<400>  155
Met Glu Asp Lys Asn Ile Leu Tyr Gly Pro Glu Pro Phe His Pro 
1               5                   10                  15  

Leu Ala Asp Gly Thr Ala Gly Glu Gln Met Phe Tyr Ala Leu Ser 
                20                  25                  30  

Arg Tyr Ala Asp Ile Ser Gly Cys Ile Ala Leu Thr Asn Ala His 
                35                  40                  45  

Thr Lys Glu Asn Val Leu Tyr Glu Glu Phe Leu Lys Leu Ser Cys 
                50                  55                  60  

Arg Leu Ala Glu Ser Phe Lys Lys Tyr Gly Leu Lys Gln Asn Asp 
                65                  70                  75  

Thr Ile Ala Val Cys Ser Glu Asn Gly Leu Gln Phe Phe Leu Pro 
                80                  85                  90  

Leu Ile Ala Ser Leu Tyr Leu Gly Ile Ile Ala Ala Pro Val Ser 
                95                  100                 105 

Asp Lys Tyr Ile Glu Arg Glu Leu Ile His Ser Leu Gly Ile Val 
                110                 115                 120 

Lys Pro Arg Ile Ile Phe Cys Ser Lys Asn Thr Phe Gln Lys Val 
                125                 130                 135 

Leu Asn Val Lys Ser Lys Leu Lys Tyr Val Glu Thr Ile Ile Ile 
                140                 145                 150 

Leu Asp Leu Asn Glu Asp Leu Gly Gly Tyr Gln Cys Leu Asn Asn 
                155                 160                 165 

Phe Ile Ser Gln Asn Ser Asp Ile Asn Leu Asp Val Lys Lys Phe 
                170                 175                 180 

Lys Pro Asn Ser Phe Asn Arg Asp Asp Gln Val Ala Leu Val Met 
                185                 190                 195 

Phe Ser Ser Gly Thr Thr Gly Val Ser Lys Gly Val Met Leu Thr 
                200                 205                 210 

His Lys Asn Ile Val Ala Arg Phe Ser His Cys Lys Asp Pro Thr 
                215                 220                 225 

Phe Gly Asn Ala Ile Asn Pro Thr Thr Ala Ile Leu Thr Val Ile 
                230                 235                 240 

Pro Phe His His Gly Phe Gly Met Thr Thr Thr Leu Gly Tyr Phe 
                245                 250                 255 

Thr Cys Gly Phe Arg Val Ala Leu Met His Thr Phe Glu Glu Lys 
                260                 265                 270 

Leu Phe Leu Gln Ser Leu Gln Asp Tyr Lys Val Glu Ser Thr Leu 
                275                 280                 285 

Leu Val Pro Thr Leu Met Ala Phe Phe Pro Lys Ser Ala Leu Val 
                290                 295                 300 

Glu Lys Tyr Asp Leu Ser His Leu Lys Glu Ile Ala Ser Gly Gly 
                305                 310                 315 

Ala Pro Leu Ser Lys Glu Ile Gly Glu Met Val Lys Lys Arg Phe 
                320                 325                 330 

Lys Leu Asn Phe Val Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr 
                335                 340                 345 

Ser Ala Val Leu Ile Thr Pro Asp Thr Asp Val Arg Pro Gly Ser 
                350                 355                 360 

Thr Gly Lys Ile Val Pro Phe His Ala Val Lys Val Val Asp Pro 
                365                 370                 375 

Thr Thr Gly Lys Ile Leu Gly Pro Asn Glu Thr Gly Glu Leu Tyr 
                380                 385                 390 

Phe Lys Gly Asp Met Ile Met Lys Ser Tyr Tyr Asn Asn Glu Glu 
                395                 400                 405 

Ala Thr Lys Ala Ile Ile Asn Lys Asp Gly Trp Leu Arg Ser Gly 
                410                 415                 420 

Asp Ile Ala Tyr Tyr Asp Asn Asp Gly His Phe Tyr Ile Val Asp 
                425                 430                 435 

Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro 
                440                 445                 450 

Ala Glu Ile Glu Gly Ile Leu Leu Gln His Pro Tyr Ile Val Asp 
                455                 460                 465 

Ala Gly Val Thr Gly Ile Pro Asp Glu Ala Ala Gly Glu Leu Pro 
                470                 475                 480 

Ala Ala Gly Val Val Val Gln Thr Gly Lys Tyr Leu Asn Glu Gln 
                485                 490                 495 

Ile Val Gln Asn Phe Val Ser Ser Gln Val Ser Thr Ala Lys Trp 
                500                 505                 510 

Leu Arg Gly Gly Val Lys Phe Leu Asp Glu Ile Pro Lys Gly Ser 
                515                 520                 525 

Thr Gly Lys Ile Asp Arg Lys Val Leu Arg Gln Met Phe Glu Lys 
                530                 535                 540 

His Lys Ser Lys Leu 
                545 


<210>  156
<211>  548
<212>  PRT
<213>  Luciola mingrelica

<220>
<223>  Luciferase of Luciola mingrelica - GenBank AAB26932.1

<400>  156
Met Glu Met Glu Lys Glu Glu Asn Val Val Tyr Gly Pro Leu Pro 
1               5                   10                  15  

Phe Tyr Pro Ile Glu Glu Gly Ser Ala Gly Ile Gln Leu His Lys 
                20                  25                  30  

Tyr Met His Gln Tyr Ala Lys Leu Gly Ala Ile Ala Phe Ser Asn 
                35                  40                  45  

Ala Leu Thr Gly Val Asp Ile Ser Tyr Gln Glu Tyr Phe Asp Ile 
                50                  55                  60  

Thr Cys Arg Leu Ala Glu Ala Met Lys Asn Phe Gly Met Lys Pro 
                65                  70                  75  

Glu Glu His Ile Ala Leu Cys Ser Glu Asn Cys Glu Glu Phe Phe 
                80                  85                  90  

Ile Pro Val Leu Ala Gly Leu Tyr Ile Gly Val Ala Val Ala Pro 
                95                  100                 105 

Thr Asn Glu Ile Tyr Thr Leu Arg Glu Leu Asn His Ser Leu Gly 
                110                 115                 120 

Ile Ala Gln Pro Thr Ile Val Phe Ser Ser Arg Lys Gly Leu Pro 
                125                 130                 135 

Lys Val Leu Glu Val Gln Lys Thr Val Thr Cys Ile Lys Lys Ile 
                140                 145                 150 

Val Ile Leu Asp Ser Lys Val Asn Phe Gly Gly His Asp Cys Met 
                155                 160                 165 

Glu Thr Phe Ile Lys Lys His Val Glu Leu Gly Phe Gln Pro Ser 
                170                 175                 180 

Ser Phe Val Pro Ile Asp Val Lys Asn Arg Lys Gln His Val Ala 
                185                 190                 195 

Leu Leu Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
                200                 205                 210 

Arg Ile Thr His Glu Gly Ala Val Thr Arg Phe Ser His Ala Lys 
                215                 220                 225 

Asp Pro Ile Tyr Gly Asn Gln Val Ser Pro Gly Thr Ala Ile Leu 
                230                 235                 240 

Thr Val Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu 
                245                 250                 255 

Gly Tyr Phe Ala Cys Gly Tyr Arg Val Val Met Leu Thr Lys Phe 
                260                 265                 270 

Asp Glu Glu Leu Phe Leu Arg Thr Leu Gln Asp Tyr Lys Cys Thr 
                275                 280                 285 

Ser Val Ile Leu Val Pro Thr Leu Phe Ala Ile Leu Asn Lys Ser 
                290                 295                 300 

Glu Leu Ile Asp Lys Phe Asp Leu Ser Asn Leu Thr Glu Ile Ala 
                305                 310                 315 

Ser Gly Gly Ala Pro Leu Ala Lys Glu Val Gly Glu Ala Val Ala 
                320                 325                 330 

Arg Arg Phe Asn Leu Pro Gly Val Arg Gln Gly Tyr Gly Leu Thr 
                335                 340                 345 

Glu Thr Thr Ser Ala Phe Ile Ile Thr Pro Glu Gly Asp Asp Lys 
                350                 355                 360 

Pro Gly Ala Ser Gly Lys Val Val Pro Leu Phe Lys Val Lys Val 
                365                 370                 375 

Ile Asp Leu Asp Thr Lys Lys Thr Leu Gly Val Asn Arg Arg Gly 
                380                 385                 390 

Glu Ile Cys Val Lys Gly Pro Ser Leu Met Leu Gly Tyr Ser Asn 
                395                 400                 405 

Asn Pro Glu Ala Thr Arg Glu Thr Ile Asp Glu Glu Gly Trp Leu 
                410                 415                 420 

His Thr Gly Asp Ile Gly Tyr Tyr Asp Glu Asp Glu His Phe Phe 
                425                 430                 435 

Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
                440                 445                 450 

Val Pro Pro Ala Glu Leu Glu Ser Val Leu Leu Gln His Pro Asn 
                455                 460                 465 

Ile Phe Asp Ala Gly Val Ala Gly Val Pro Asp Pro Asp Ala Gly 
                470                 475                 480 

Glu Leu Pro Gly Ala Val Val Val Met Glu Lys Gly Lys Thr Met 
                485                 490                 495 

Thr Glu Lys Glu Ile Val Asp Tyr Val Asn Ser Gln Val Val Asn 
                500                 505                 510 

His Lys Arg Leu Arg Gly Gly Val Arg Phe Val Asp Glu Val Pro 
                515                 520                 525 

Lys Gly Leu Thr Gly Lys Ile Asp Ala Lys Val Ile Arg Glu Ile 
                530                 535                 540 

Leu Lys Lys Pro Gln Ala Lys Met 
                545             


<210>  157
<211>  2209
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CL5 gamma delta TCR

<400>  157
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt                 50
tgcaaggcat ggaaaataca taactgagaa tagagaagtt cagatcaagg                 100
ttaggaacag agagacagca gaatatgggc caaacaggat atctgtggta                 150
agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg                 200
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc                 250
ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt                 300
cgcttctcgc ttctgttcgc gcgaattcac catggtgtcc ctgctgcacg                 350
ccagcaccct ggccgtgctg ggcgccctgt gcgtgtatgg cgccggacac                 400
ctggaacagc cccagatcag cagcaccaag accctgagca agaccgccag                 450
gctggaatgc gtggtgtccg gcatcaccat cagcgccacc tccgtgtact                 500
ggtacagaga gagacccggc gaggtcatcc agttcctggt gtccatcagc                 550
tacgacggca ccgtgcggaa agagagcggc atccccagcg gcaagttcga                 600
ggtggacaga atccccgaga ccagcacctc caccctgacc atccacaacg                 650
tggagaagca ggacatcgcc acctactact gcgccctgtg ggagatccag                 700
gaactgggca agaaaatcaa ggtgttcggc cctggcacca agctgatcat                 750
caccgacaag cagctggacg ccgacgtgag ccccaagcct accatcttcc                 800
tgcccagcat cgccgagacc aagctgcaga aggccggcac ctacctgtgc                 850
ctgctggaaa agttcttccc cgacgtgatc aagatccact gggaggaaaa                 900
gaagagcaac accatcctgg gcagccagga aggcaatacc atgaaaacca                 950
acgacaccta catgaagttc agctggctga ccgtgcccga gaagagcctg                 1000
gacaaagagc acagatgcat cgtccggcac gagaacaaca agaacggcgt                 1050
ggaccaggaa atcatcttcc cccccatcaa gaccgatgtg atcacaatgg                 1100
accccaagga caactgcagc aaggacgcca acgataccct gctgctgcag                 1150
ctgaccaaca ccagcgccta ctacatgtat ctcctgctgc tgctgaagag                 1200
cgtggtgtac ttcgccatca tcacctgctg tctgctgcgg cggaccgcct                 1250
tctgctgcaa cggcgagaag agcggcagcg gcgaaggccg cggcagcctg                 1300
ctgacctgcg gcgatgtgga agaaaaccct ggcccgatgg agcggatcag                 1350
cagcctgatc cacctgagcc tgttctgggc cggagtgatg agcgccatcg                 1400
agctggtgcc cgagcaccag accgtgcccg tgagcatcgg cgtgcccgcc                 1450
accctgcggt gcagcatgaa gggcgaggcc atcggcaact actacatcaa                 1500
ctggtacaga aagacccagg gcaacaccat gaccttcatc taccgggaga                 1550
aggacatcta cggccctggc ttcaaggaca acttccaggg cgacatcgac                 1600
atcgccaaga acctggccgt gctgaagatc ctggccccca gcgagaggga                 1650
cgagggcagc tactactgcg cctgcgacgc cctgaagaga accgacaccg                 1700
acaagctgat cttcggcaag ggcacccggg tgaccgtgga gcccagaagc                 1750
cagccccaca ccaagcccag cgtgttcgtg atgaagaacg gcaccaacgt                 1800
ggcctgcctg gtgaaagagt tctaccccaa ggacatccgg atcaacctgg                 1850
tgtccagcaa gaagatcacc gagttcgacc ccgccatcgt gatcagcccc                 1900
agcggcaagt acaacgccgt gaagctgggc aagtacgagg acagcaacag                 1950
cgtgacctgc agcgtgcagc acgacaacaa gaccgtgcac agcaccgact                 2000
tcgaggtgaa aaccgactcc accgaccacg tgaagcccaa agagaccgag                 2050
aacaccaagc agcccagcaa gagctgccac aagcccaagg ccatcgtgca                 2100
caccgagaag gtgaacatga tgagcctgac cgtgctgggc ctgcggatgc                 2150
tgttcgccaa gacagtggcc gtgaacttcc tgctgaccgc caagctgttc                 2200
ttcctgtga                                                              2209


<210>  158
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  TRCA gRNA #1

<400>  158
acaaaacugu gcuagacaug                                                  20


<210>  159
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  TRCA gRNA #2

<400>  159
gagaaucaaa aucggugaau                                                  20


<210>  160
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  TRCA gRNA #3

<400>  160
cucucagcug guacacggca                                                  20


<210>  161
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70

<400>  161
Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
1               5                   10                  15  

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                20                  25                  30  

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                35                  40                  45  

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                50                  55                  60  

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                65                  70                  75  

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                80                  85                  90  

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                95                  100                 105 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                110                 115                 120 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                125                 130                 135 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                140                 145                 150 

Gln Trp Val Arg Pro 
                155 


<210>  162
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL2RB ICD

<400>  162
Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln Leu Ser Leu 
1               5                   10                  15  

Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val Lys Asp Arg 
                20                  25                  30  

Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu Gly Gly Pro 
                35                  40                  45  

Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp Lys Gln Val 
                50                  55                  60  

Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe Lys Ser Pro 
                65                  70                  75  

Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp Pro Gly Thr 
                80                  85                  90  

Asn Arg Cys Asn 
                


<210>  163
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70-TM

<400>  163
Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
1               5                   10                  15  

Cys Leu Val Val Cys Ile 
                20      


<210>  164
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-13W-OX40

<400>  164
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Pro 
                35                  40                  45  

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
                50                  55                  60  

Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
                65                  70                  75  

Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                80                  85                  90  

Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                95                  100                 105 

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                110                 115                 120 

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                125                 130                 135 

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                140                 145                 150 

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
                155                 160                 165 

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                170                 175                 180 

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                185                 190                 195 

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                200                 205                 210 

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                215                 220                 225 

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
                230                 235                 240 

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                245                 250                 255 

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                260                 265                 270 

Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280             


<210>  165
<211>  392
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40-IL2RB

<400>  165
Met Leu Gly Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln 
1               5                   10                  15  

Leu Ser Leu Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val 
                20                  25                  30  

Lys Asp Arg Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu 
                35                  40                  45  

Gly Gly Pro Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp 
                50                  55                  60  

Lys Gln Val Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe 
                65                  70                  75  

Lys Ser Pro Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp 
                80                  85                  90  

Pro Gly Thr Asn Arg Cys Asn Gly Ser Gly Arg Asp Gln Arg Leu 
                95                  100                 105 

Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
                110                 115                 120 

Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys 
                125                 130                 135 

Ile Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu 
                140                 145                 150 

Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu 
                155                 160                 165 

Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala 
                170                 175                 180 

Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly 
                185                 190                 195 

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
                200                 205                 210 

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
                215                 220                 225 

Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                230                 235                 240 

Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
                245                 250                 255 

Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                260                 265                 270 

Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                275                 280                 285 

Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
                290                 295                 300 

Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
                305                 310                 315 

Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                320                 325                 330 

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                335                 340                 345 

Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
                350                 355                 360 

Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
                365                 370                 375 

Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                380                 385                 390 

Ser Glu 
        


<210>  166
<211>  195
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70

<400>  166
Met Leu Gly Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg 
1               5                   10                  15  

Pro Tyr Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
                20                  25                  30  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                35                  40                  45  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                50                  55                  60  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                65                  70                  75  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                80                  85                  90  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                95                  100                 105 

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                110                 115                 120 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                125                 130                 135 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                140                 145                 150 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                155                 160                 165 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                170                 175                 180 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                185                 190                 195 





<210>  167
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto

<400>  167
Met Leu Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
1               5                   10                  15  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                20                  25                  30  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                35                  40                  45  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                50                  55                  60  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                65                  70                  75  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                80                  85                  90  

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                95                  100                 105 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                110                 115                 120 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                125                 130                 135 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                140                 145                 150 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                155                 160                 165 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                170                 175                 180 





<210>  168
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto-OX40

<400>  168
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Gly Cys 
                35                  40                  45  

Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
                50                  55                  60  

Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln 
                65                  70                  75  

Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu 
                80                  85                  90  

Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly 
                95                  100                 105 

Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp 
                110                 115                 120 

Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met Val His 
                125                 130                 135 

Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg 
                140                 145                 150 

His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser 
                155                 160                 165 

Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr 
                170                 175                 180 

Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu 
                185                 190                 195 

Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
                200                 205                 210 

Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                215                 220     


<210>  169
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70-41BBL-OX40

<400>  169
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
                95                  100                 105 

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                110                 115                 120 

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                125                 130                 135 

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                140                 145                 150 

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                155                 160                 165 

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                170                 175                 180 

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                185                 190                 195 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                200                 205                 210 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                215                 220                 225 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                230                 235                 240 

Gln Trp Val Arg Pro 
                245 


<210>  170
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VG5 S98

<400>  170
Cys Ala Thr Trp Asp Ser Pro Gly Arg Tyr Pro Asn Tyr Lys Lys 
1               5                   10                  15  

Leu Phe 
        


<210>  171
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 VD3 S98

<400>  171
Cys Ala Phe Ser Ser Lys Ala Phe Leu Pro His Arg Thr Lys Asn 
1               5                   10                  15  

Pro Tyr Leu Thr Asp Lys Leu Ile Phe 
                20                  


<210>  172
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG S98

<400>  172
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Gly Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Pro Thr Arg Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Ile Asn Ala Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Asn Ser Lys Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Ser Pro Gly 
                110                 115                 120 

Arg Tyr Pro Asn Tyr Lys Lys Leu Phe 
                125                 


<210>  173
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD S98

<400>  173
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr 
                110 


<210>  174
<211>  3610
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NFAT eGFP_LUC-PGK_Q8

<400>  174
tctagactgc cggatccaag ctggaggaaa aactgtttca tacagaaggc                 50
gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca                 100
tacagaaggc gtggaggaaa aactgtttca tacagaaggc gtcgcgaatt                 150
cgcggagact ctagagggta tataatggaa gctcgatttc cagcttggca                 200
ttccggtact gttggtaaac accaagcgcc accatggtga gcaagggcga                 250
ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg                 300
taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc                 350
tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt                 400
gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca                 450
gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg                 500
cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa                 550
ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc                 600
gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg                 650
cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga                 700
caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg                 750
aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc                 800
ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc                 850
cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg                 900
agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag                 950
ggcagcggcg aaggccgcgg cagcctgctg acctgcggcg atgtggaaga                 1000
aaaccctggg cccatggagg acgccaagaa catcaagaag ggccctgcac                 1050
ctttctaccc cttggaggac ggcaccgccg gagagcagct gcacaaggcc                 1100
atgaagaggt acgccttggt gcctggcacc atcgccttca ccgacgccca                 1150
catcgaggtg gacatcacct acgccgagta cttcgagatg agcgtgaggt                 1200
tggccgaggc catgaagcgg tacggcctga acaccaacca ccggatcgtg                 1250
gtgtgcagcg agaacagcct gcaattcttc atgcctgtcc tcggagcctt                 1300
gttcatcggc gttgccgtgg ctcctgccaa cgacatctac aacgagcggg                 1350
agctgctgaa cagcatgggc atcagccagc ctaccgtggt gttcgtgagc                 1400
aagaagggcc tccagaagat cctgaacgtg cagaagaagc tgcctatcat                 1450
ccagaagatc atcatcatgg acagcaagac cgactaccag ggcttccaga                 1500
gcatgtacac cttcgtcacc agccacctgc ctcctggctt caacgagtac                 1550
gacttcgtgc ctgagagctt cgacagggac aagacaatcg ctctgatcat                 1600
gaacagcagc ggcagcaccg gcctgcctaa gggcgttgcc ctgcctcaca                 1650
ggaccgcctg cgtgaggttc agccacgcta gagaccctat cttcggcaac                 1700
cagatcatcc ctgacaccgc tatcctgagc gtcgtgcctt tccaccacgg                 1750
ctttggcatg ttcaccaccc tgggctacct gatctgtggc ttcagggtgg                 1800
tgctgatgta caggttcgag gaggagctgt tcctgcggag cctgcaggac                 1850
tacaagatcc agagcgcact gctggtgcct accctgttca gcttcttcgc                 1900
caagagcacc ctgatcgaca agtacgacct gagcaacctg cacgagatcg                 1950
ccagcggcgg agctcctctg agcaaggagg tcggcgaggc cgtcgccaag                 2000
aggttccacc tgcctggcat ccggcagggc tacggcctga ccgagaccac                 2050
cagcgccatc ctgatcacac ctgagggcga cgacaagcct ggcgctgtgg                 2100
gcaaggtcgt gccattcttc gaggccaagg ttgtggacct ggacaccggc                 2150
aagaccctgg gagtgaacca gagaggcgag ctgtgcgtga gaggccctat                 2200
gatcatgagc ggctacgtga acaaccctga ggccaccaac gctctgatcg                 2250
acaaggacgg atggctgcac agcggcgaca tcgcctactg ggacgaggac                 2300
gagcacttct tcatcgtgga ccggctgaag agcctgatca agtacaaagg                 2350
ctaccaggtc gcccctgccg agctggagag catcctgctg cagcacccta                 2400
acatcttcga cgccggcgtg gctggcctgc ctgacgacga cgctggcgag                 2450
ctgccagctg ctgtcgtggt gctggagcac ggcaagacca tgaccgagaa                 2500
ggagatcgtg gactacgtgg ccagccaggt gaccaccgcc aagaagctga                 2550
gaggcggcgt tgtgttcgtc gacgaggtgc ctaagggcct gaccggcaag                 2600
ctggacgctc ggaagatcag agagatcctg atcaaggcca agaagggagg                 2650
aaagatcgcc gtgaggagga agcggtgaca ggatccaggg taggggaggc                 2700
gcttttccca aggcagtctg gagcatgcgc tttagcagcc ccgctgggca                 2750
cttggcgcta cacaagtggc ctctggcctc gcacacattc cacatccacc                 2800
ggtaggcgcc aaccggctcc gttctttggt ggccccttcg cgccaccttc                 2850
tactcctccc ctagtcagga agttcccccc cgccccgcag ctcgcgtcgt                 2900
gcaggacgtg acaaatggaa gtagcacgtc tcactagtct cgtgcagatg                 2950
gacagcaccg ctgagcaatg gaagcgggta ggcctttggg gcagcggcca                 3000
atagcagctt tgctccttcg ctttctgggc tcagaggctg ggaaggggtg                 3050
ggtccggggg cgggctcagg ggcgggctca ggggcggggc gggcgcccga                 3100
aggtcctccg gaggcccggc attctgcacg cttcaaaagc gcacgtctgc                 3150
cgcgctgttc tcctcttcct catctccggg cctttcggaa ttcaccatgg                 3200
gactcgttag aagaggcgcc agagccggac ctagaatccc tagaggatgg                 3250
acagccctgt gcctgctgtc tctgctgcct tctggcttta tggccgagct                 3300
gcctacacag ggcaccttca gcaatgtgtc caccaacgtg tccccagcca                 3350
agcctacaac aacccctgct cctagacctc ctacaccagc tcctacaatc                 3400
gccagccagc cactgtctct gaggccagaa gcttgtagac ctgctgctgg                 3450
cggagccgtg catacaagag gactggattt cgcctgcgac atctacatct                 3500
gggcccctct ggctggaaca tgtggcgttc tgctgctgag cctggtcatc                 3550
accctgtact gcaaccaccg gaacaggcgg agagtgtgca agtgccctag                 3600
acctgtggtt                                                             3610







