               SEQUENCE LISTING

<110> MOLECULAR PARTNERS AG

<120> NOVEL DARPin BASED CD70 ENGAGERS

<130> P035

<160> 82

<170> BiSSAP 1.3.6

<210> 1
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 1

<400> 1
Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val Gln Ser 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 2
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 2

<400> 2
Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val Gln Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 3
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 3

<400> 3
Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Val Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Thr Arg Gly Ile Thr Pro Leu His Asp Thr Ala Phe Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Thr Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Asn Glu Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 4
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 4

<400> 4
Asp Leu Gly Phe Lys Leu Leu Gln Ala Ala Leu Arg Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Leu Gly Thr Thr Pro Leu His Leu Ala Ala His Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Trp Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Arg Ala Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Glu Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 5
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 5

<400> 5
Asp Leu Gly Phe Lys Leu Leu Gln Ala Ala Leu Arg Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Leu Gly Thr Thr Pro Leu His Leu Ala Ala His Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Trp Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Arg Ala Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Glu Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 6
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 6

<400> 6
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Thr Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ala Arg Gly Ser Thr Pro Leu His Val Ala Ala Ile His Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Thr Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Glu Glu Gly Gln Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 7
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 7

<400> 7
Asp Leu Gly Ala Lys Leu Leu Asn Ala Ala Thr Val Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Trp Ser Gly Gln Thr Pro Leu His His Ala Ala Tyr Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Ser Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Glu Gly Ser Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 8
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 8

<400> 8
Asp Leu Gly His Lys Leu Leu Phe Ala Ala Val Arg Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Thr Arg Gly Val Thr Pro Leu His Leu Ala Ala Ser Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Leu Gly Asn Thr Pro Leu His Leu Ala Ala Thr Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Trp Val Gly Lys Thr Pro Ala Asp Leu Ala Ala Trp Trp Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 9
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 9

<400> 9
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Ala Gly Leu Thr Pro Leu His Ile Ala Ala Ala Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Gln His Gly Gln Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 10
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 10

<400> 10
Asp Leu Gly Phe Lys Leu Leu Asn Ala Ala Val Gln Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Leu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Gln Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Trp Gly Ala Thr Pro Leu His Leu Ala Ala Glu His Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Asn Ala Gly Lys Thr Pro Ala Asp Leu Ala Ala Gln Asp Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 11
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 11

<400> 11
Asp Leu Gly Ile Lys Leu Leu Tyr Ala Ala Tyr Phe Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Trp Leu Gly Lys Thr Pro Leu His Leu Ala Ala Thr Glu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Trp Gly Glu Thr Pro Leu His Lys Ala Ala Gln Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ser Ala Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Val Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 12
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 12

<400> 12
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Thr Gly Tyr Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Phe Ile Gly Pro 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Glu Gln Gly Ala Thr Pro Leu His Leu Ala Ala Trp Gln Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 13
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 13

<400> 13
Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val Gln Ser 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 14
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 14

<400> 14
Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val Gln Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 15
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 15

<400> 15
Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Val Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Thr Arg Gly Ile Thr Pro Leu His Asp Thr Ala Phe Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Thr Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Asn Glu Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 16
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 16

<400> 16
Asp Leu Gly Phe Lys Leu Leu Gln Ala Ala Leu Arg Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Leu Gly Thr Thr Pro Leu His Leu Ala Ala His Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Trp Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Arg Ala Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Glu Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 17
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 17

<400> 17
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Thr Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ala Arg Gly Ser Thr Pro Leu His Val Ala Ala Ile His Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Thr Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Glu Glu Gly Gln Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 18
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 18

<400> 18
Asp Leu Gly Ala Lys Leu Leu Asn Ala Ala Thr Val Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Trp Ser Gly Gln Thr Pro Leu His His Ala Ala Tyr Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Ser Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Glu Gly Ser Thr Pro Ala Asp Leu Ala Ala Phe His Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 19
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 19

<400> 19
Asp Leu Gly His Lys Leu Leu Phe Ala Ala Val Arg Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Thr Arg Gly Val Thr Pro Leu His Leu Ala Ala Ser Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Leu Gly Asn Thr Pro Leu His Leu Ala Ala Thr Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Trp Val Gly Lys Thr Pro Ala Asp Leu Ala Ala Trp Trp Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 20
<211> 305
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 20

<400> 20
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Ala Gly Leu Thr Pro Leu His Ile Ala Ala Ala Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Gln His Gly Gln Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala 
    210                 215                 220                 
Gln Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala 
305 

<210> 21
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 21

<400> 21
Asp Leu Gly Phe Lys Leu Leu Asn Ala Ala Val Gln Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Leu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Gln Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Trp Gly Ala Thr Pro Leu His Leu Ala Ala Glu His Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Asn Ala Gly Lys Thr Pro Ala Asp Leu Ala Ala Gln Asp Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 22
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 22

<400> 22
Asp Leu Gly Ile Lys Leu Leu Tyr Ala Ala Tyr Phe Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Trp Leu Gly Lys Thr Pro Leu His Leu Ala Ala Thr Glu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Trp Gly Glu Thr Pro Leu His Lys Ala Ala Gln Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ser Ala Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Val Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 23
<211> 305
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 23

<400> 23
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Thr Gly Tyr Thr Pro Leu His Leu Ala Ala Arg His Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Phe Ile Gly Pro 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Glu Gln Gly Ala Thr Pro Leu His Leu Ala Ala Trp Gln Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala 
    210                 215                 220                 
Gln Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Lys Tyr Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala 
305 

<210> 24
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 24
Lys Asp Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 25
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 25
Lys Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 26
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 26
Lys Asp Thr Arg Gly Ile Thr Pro Leu His Asp Thr Ala Phe Tyr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 27
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 27
Lys Asp Val Thr Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 28
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 28
Lys Asp Gln Leu Gly Thr Thr Pro Leu His Leu Ala Ala His Tyr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 29
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 29
Lys Asp Val Trp Gly Asp Thr Pro Leu His Leu Ala Ala Gln His Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 30
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 30
Lys Asp Ala Arg Gly Ser Thr Pro Leu His Val Ala Ala Ile His Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 31
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 31
Lys Asp Thr Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 32
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 32
Lys Asp Trp Ser Gly Gln Thr Pro Leu His His Ala Ala Tyr Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 33
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 33
Lys Asp Ser Trp Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 34
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 34
Lys Asp Thr Arg Gly Val Thr Pro Leu His Leu Ala Ala Ser Trp Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 35
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 35
Lys Asp Glu Leu Gly Asn Thr Pro Leu His Leu Ala Ala Thr Asp Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 36
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 36
Lys Asp Gln Ala Gly Leu Thr Pro Leu His Ile Ala Ala Ala Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 37
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 37
Lys Asp Phe Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 38
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 38
Lys Asp Gln His Gly Gln Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 39
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 39
Lys Asp Leu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Gln Phe Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 40
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 40
Lys Asp Val Trp Gly Ala Thr Pro Leu His Leu Ala Ala Glu His Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 41
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 41
Lys Asp Trp Leu Gly Lys Thr Pro Leu His Leu Ala Ala Thr Glu Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 42
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 42
Lys Asp Glu Trp Gly Glu Thr Pro Leu His Lys Ala Ala Gln Glu Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 43
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 43
Lys Asp Gln Thr Gly Tyr Thr Pro Leu His Leu Ala Ala Arg His Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 44
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 44
Lys Asp Glu Tyr Gly Trp Thr Pro Leu His Ile Ala Ala Phe Ile Gly 
1               5                   10                  15      
Pro Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 45
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 45
Lys Asp Glu Gln Gly Ala Thr Pro Leu His Leu Ala Ala Trp Gln Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 46
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 46
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  

<210> 47
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-Cap (randomized)

<220> 
<221> VARIANT
<222> 4,8,11,12
<223> wherein Xaa denotes any amino acid (preferably not cysteine,
      glycine, or proline)

<400> 47
Asp Leu Gly Xaa Lys Leu Leu Xaa Ala Ala Xaa Xaa Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  

<210> 48
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-cap

<400> 48
Gln Asp Lys Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Asn Gly 
1               5                   10                  15      
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
            20                  25              

<210> 49
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-cap

<400> 49
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
1               5                   10                  15      
His Gln Asp Ile Ala Glu Val Leu Gln Lys Leu Ala 
            20                  25              

<210> 50
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-cap

<400> 50
Gln Asp Ser Ser Gly Phe Thr Pro Ala Asp Leu Ala Ala Leu Val Gly 
1               5                   10                  15      
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              

<210> 51
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-cap (randomized)

<220> 
<221> VARIANT
<222> 3,4,6,14,15
<223> wherein Xaa denotes any amino acid (preferably not cysteine,
      glycine, or proline)

<400> 51
Gln Asp Xaa Xaa Gly Xaa Thr Pro Ala Asp Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
            20                  25              

<210> 52
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for human serum albumin

<400> 52
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 53
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for human serum albumin

<400> 53
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 54
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for human serum albumin

<400> 54
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asp Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 55
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD3

<400> 55
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Gln Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              
Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 56
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD3

<400> 56
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          
Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              
Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp Lys Gly Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 57
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD3

<400> 57
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          
Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              
Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 58
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD3

<400> 58
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          
Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              
Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Thr Asn Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Arg Asp Thr Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Arg Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 59
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD3

<400> 59
Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asn 
            20                  25                  30          
Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln Thr Gly His Leu 
        35                  40                  45              
Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala Ala Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Gly Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
        115                 120                 

<210> 60
<211> 142
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD70 target protein (ECD)

<400> 60
Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro 
1               5                   10                  15      
Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
            20                  25                  30          
Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His 
        35                  40                  45              
Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys 
    50                  55                  60                  
Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly 
65                  70                  75                  80  
Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe 
                85                  90                  95      
His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
            100                 105                 110         
Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg 
        115                 120                 125             
Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
    130                 135                 140         

<210> 61
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD70

<400> 61
Gly Ser Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val 
            100                 105                 110         
Gln Ser His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 62
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<220> 
<221> VARIANT
<222> 1,3,4,6,13,14,15,17,18,19,22,26,27
<223> wherein Xaa denotes any amino acid (preferably not cysteine,
      glycine, or proline)

<400> 62
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Xaa Xaa Xaa Gly 
1               5                   10                  15      
Xaa Xaa Xaa Leu Val Xaa Val Leu Leu Xaa Xaa Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 63
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<220> 
<221> VARIANT
<222> 1,3,4,6,14,15,27
<223> wherein Xaa in positions 1, 3, 4, 6, 14, 15 denotes any amino
      acid (preferably not cysteine, glycine, or proline), and Xaa in
      position 27 is selected from the group consisting of asparagine,
      histidine, or tyrosine

<400> 63
Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 64
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat domain specific for CD70

<400> 64
Gly Ser Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val 
            100                 105                 110         
Gln Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 65
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> PT-rich peptide linker

<400> 65
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro Thr Gly Ser 
            20                  

<210> 66
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> PT-rich peptide linker

<400> 66
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro 
            20      

<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus GS linker

<220> 
<221> VARIANT
<222> 1..5
<223> [Gly-Gly-Gly-Gly-Ser]n, wherein n is 1, 2, 3, 4, 5, or 6

<400> 67
Gly Gly Gly Gly Ser 
1               5   

<210> 68
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> His-tag

<400> 68
Met Arg Gly Ser His His His His His His 
1               5                   10  

<210> 69
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 69
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  

<210> 70
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 70
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30  

<210> 71
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 24

<400> 71
Asp Leu Gly Ile Lys Leu Leu Thr Ala Ala Tyr Asp Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Leu Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Gly Leu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Leu His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Val Glu Gly Val Thr Pro Ala Asp Leu Ala Ala Val Gln Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 72
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 25

<400> 72
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Gln Gly Leu Thr Pro Leu His Ile Ala Ala Asn Leu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Leu Phe Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Gln His Gly Ala Thr Pro Leu His Leu Ala Ala Trp Val Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 73
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 73
Lys Asp Leu Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Gly Leu Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 74
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 74
Lys Asp Leu His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 75
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 75
Lys Asp Gln Ala Gly Leu Thr Pro Leu His Ile Ala Ala Ala Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 76
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 76
Lys Asp Phe Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 77
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Ankyrin repeat module

<400> 77
Lys Asp Gln His Gly Gln Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
1               5                   10                  15      
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 78
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 26

<400> 78
Asp Leu Gly Ile Lys Leu Leu Thr Ala Ala Tyr Asp Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Leu Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Gly Leu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Leu His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Val Glu Gly Val Thr Pro Ala Asp Leu Ala Ala Val Gln Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 79
<211> 305
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 27

<400> 79
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Gln Gly Leu Thr Pro Leu His Ile Ala Ala Asn Leu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Leu Phe Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Gln His Gly Ala Thr Pro Leu His Leu Ala Ala Trp Val Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala 
    210                 215                 220                 
Gln Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Lys Tyr Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala 
305 

<210> 80
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 28

<400> 80
Asp Leu Gly Tyr Lys Leu Leu Gln Ala Ala Tyr Asp Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Arg Gly Gln Thr Pro Leu His Tyr Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Asp His Gly Trp Thr Pro Leu His Leu Ala Ala Trp Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Glu Gly Thr Thr Pro Ala Asp Leu Ala Ala Val Gln Gly 
            100                 105                 110         
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala Gln 
            180                 185                 190         
Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Lys Tyr Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 81
<211> 305
<212> PRT
<213> Artificial Sequence


<220> 
<223> DARPin protein 29

<400> 81
Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Gln Ala Gly Leu Thr Pro Leu His Ile Ala Ala Ala Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Gln His Gly Gln Thr Pro Leu His Leu Ala Ala Trp Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala 
    130                 135                 140                 
Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu Glu Ala Ala Trp 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Ser Arg Gly Trp Thr Pro Leu His Thr Ala Ala 
    210                 215                 220                 
Gln Thr Gly His Leu Glu Ile Phe Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asn Asp Lys Arg Val Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Arg Asp Ser Trp Gly Thr Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Lys Tyr Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala 
305 

<210> 82
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> His-tag

<400> 82
Met Arg Gly Ser His His His His His His Gly Ser 
1               5                   10          

