                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Atomwise Inc.
       Liu, Pengda
       Su, Siyuan
       Davis, Ian Jonathan
       Laggner, Christian
 
<120>  Compound 7Ai in Treating Ewing Sarcoma by Inhibiting OTUD7A

<130>  421/498 PCT

<150>  63/170,977
<151>  2021-04-05

<160>  103   

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Thr Ser Ser Ser 
1               5   


<210>  2
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic sequence

<400>  2
gcatagatct gcgtccacgg attacagtac c                                    31


<210>  3
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3
gcatagatct gacgggacta ttaaggaggc                                      30


<210>  4
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4
gcatctcgag ctagtagtag ctgcctaagt g                                    31


<210>  5
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5
gcatggatcc tcaagggttc caagtcctcc ac                                   32


<210>  6
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6
gcatctcgag ttaggattgc ttcaggcgtt tgcg                                 34


<210>  7
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7
gcatagatct gtttctagtg tgcttccaaa cc                                   32


<210>  8
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8
gcatgtcgac tcacagctcc tcgcgg                                          26


<210>  9
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9
cctccatgcc tgtcactgcc gccgccttct ttggagccgc atcac                     45


<210>  10
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10
gtgatgcggc tccaaagaag gcggcggcag tgacaggcat ggagg                     45


<210>  11
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11
caggggatgg gaactccctt ttacatgctg cttcactg                             38


<210>  12
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12
cagtgaagca gcatgtaaaa gggagttccc atcccctg                             38


<210>  13
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic sequence

<400>  13
gttcgatcgc ttcctcctgc aatcattcaa caatgaccgt ctc                       43


<210>  14
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14
gagacggtca ttgttgaatg attgcaggag gaagcgatcg aac                       43


<210>  15
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15
tcctacagcc aagctccaag tc                                              22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16
actccccgtt ggtcccctcc                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17
cagtcactgc acctccatcc                                                 20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18
ttcatgttat tgccccaagc                                                 20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19
ctacgacagc agcgacaacc                                                 20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20
gccttggaga aaagcactcg                                                 20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21
catctgtgag aagccacagg                                                 20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22
tgcactcatc agagctacag g                                               21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23
ctgctcagat ttccccaaag                                                 20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24
tggcatcaag caggtcatag                                                 20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25
catcaagaaa gggcatgcta a                                               21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26
ctacggcagg gaccatattc t                                               21


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27
caggtctccc acaaacacat cg                                              22


<210>  28
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28
accaggtctt tatcctccaa gtagc                                           25


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29
cgcacgattt cattgaacac tt                                              22


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30
cggattggaa atacttcaca t                                               21


<210>  31
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31
cctctgtgct acagattata cctttgc                                         27


<210>  32
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32
ttgcactgca gccccaat                                                   18


<210>  33
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33
tggagaacca ggctatggac gt                                              22


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34
ccaggaactg tgagaagtgc tg                                              22


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35
ctgcggaaag tgctcatcag t                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36
tggcagagcg aacaataagg c                                               21


<210>  37
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37
gatgctgtgt gttttgatgt tgac                                            24


<210>  38
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38
cttgacttgt tgcctgatca catt                                            24


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39
cttggtagtg tttgccatcg t                                               21


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40
tgcgggtgaa gaggaagtag                                                 20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41
gagctctgaa gargcatgga g                                               21


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42
tgcttctgga ggttacagca                                                 20


<210>  43
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43
ccggcacaga tcaaggtagt gaaatctcga gatttcacta ccttgatctg tgttttttg      59


<210>  44
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  44
ccggcaaggt agtgaaattc tcctactcga gtaggagaat ttcactacct tgttttttg      59


<210>  45
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  45
ccggcaaacg cctgaagcaa tcctactcga gtaggattgc ttcaggcgtt tgttttttg      59


<210>  46
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  46
ccggctccta catgtggacc atcaactcga gttgatggtc cacatgtagg agttttttg      59


<210>  47
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  47
ccggcgtgtg ccaaatggtt tgaaactcga gtttcaaacc atttggcaca cgtttttg       58


<210>  48
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  48
ccggttcagg ctttacaacg tttatctcga gataaacgtt gtaaagcctg aatttttg       58


<210>  49
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  49
ccggcgtgtg ccaaatggtt tgaaactcga gtttcaaacc atttggcaca cgtttttg       58


<210>  50
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  50
ccggaggagt atgctgaaga tgacactcga gtgtcatctt cagcatactc ctttttt        57


<210>  51
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  51
ccggtgtttc tatcgggctt tcggactcga gtccgaaagc ccgatagaaa cattttt        57


<210>  52
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  52
ccggtgtggt tgtaaatggt cctatctcga gataggacca tttacaacca cattttt        57


<210>  53
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  53
ccggcctatg tgtcactgga ttattctcga gaataatcca gtgacacata ggtttttg       58


<210>  54
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  54
ccggtgggct gctatgtctc tgtatctcga gatacagaga catagcagcc cattttt        57


<210>  55
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  55
ccggccttcc gtttacctgc tctatctcga gatagagcag gtaaacggaa ggttttt        57


<210>  56
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  56
ccgggacgtc tgccatcgca tattactcga gtaatatgcg atggcagacg tctttttg       58


<210>  57
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  57
ccggtttgga aatcagggct taaatctcga gatttaagcc ctgatttcca aatttttg       58


<210>  58
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  58
ccgggggagt tacacatcgc atatcctcga ggatatgcga tgtgtaactc cctttttg       58


<210>  59
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  59
ccggcaagtc gagaatctaa ctattctcga gaatagttag attctcgact tgtttttg       58


<210>  60
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  60
ccggtatgca atgccttagt cataactcga gttatgacta aggcattgca tatttttg       58


<210>  61
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  61
ccggcactat agattccaaa cataactcga gttatgtttg gaatctatag tgtttttg       58


<210>  62
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  62
ccggccatca ttcaaaccag ggtttctcga gaaaccctgg tttgaatgat ggttttttg      59


<210>  63
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  63
ccggccgact acttctccaa ctatgctcga gcatagttgg agaagtagtc ggtttttg       58


<210>  64
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  64
ccggagaacg tctgagcctt caatgctcga gcattgaagg ctcagacgtt cttttttg       58


<210>  65
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  65
ccggcatgat ctactgcgac aacatctcga gatgttgtcg cagtagatca tgttttttg      59


<210>  66
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  66
ccggcaccaa ctaagatttg gtcatctcga gatgaccaaa tcttagttgg tgttttttg      59


<210>  67
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  67
ccgggatttg gtcatgttgc gtatactcga gtatacgcaa catgaccaaa tcttttttg      59


<210>  68
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  68
ccgggcaaag ctactaacag gtgttctcga gaacacctgt tagtagcttt gcttttttg      59


<210>  69
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  69
ccgggctgac tactaaggag aataactcga gttattctcc ttagtagtca gcttttttg      59


<210>  70
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  70
ccggcgatga gactaatgca gtgaactcga gttcactgca ttagtctcat cgttttttg      59


<210>  71
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  71
cgggcagcaa ttctaacagc aatactcgag tattgctgtt agaattgctg ctttttg        57


<210>  72
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  72
ccggcgcaca cacttcagca agaatctcga gattcttgct gaagtgtgtg cgtttttg       58


<210>  73
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  73
ccgggcgcga gaactgtgcg ttctactcga gtagaacgca cagttctcgc gctttttg       58


<210>  74
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  74
gtaccggttg aagagtttca cgtctttgct cgagcaaaga cgtgaaactc ttcaattttt     60

tg                                                                    62


<210>  75
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  75
ccggtggaaa tgctcacggt ttatactcga gtataaaccg tgagcatttc catttttg       58


<210>  76
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  76
ccgggcaagg aggctaaaca aagttctcga gaactttgtt tagcctcctt gcttttt        57


<210>  77
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  77
ccgggcagaa tttgcgatgt acttactcga gtaagtacat cgcaaattct gcttttt        57


<210>  78
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  78
ccgggcaagc tctataagat tcttcctcga ggaagaatct tatagagctt gcttttttg      59


<210>  79
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  79
tgcccatcct gcacacttac ttcaagagag taagtgtgca ggatgggctt ttttc          55


<210>  80
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  80
ccgggcgcga gaactgtgcg ttctactcga gtagaacgca cagttctcgc gcttttt        57


<210>  81
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  81
aattaaaaag cgcgagaact gtgcgttcta ctcgagtaga acgcacagtt ctcgcgc        57


<210>  82
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  82
ctgccagcgg gaaaattgcg cgttctacgg                                      30


<210>  83
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  83
ccgtagaacg cgcaattttc ccgctggcag                                      30


<210>  84
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  84
caccgtgcgg ctccaaagaa gctgg                                           25


<210>  85
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  85
aaacccagct tctttggagc cgcac                                           25


<210>  86
<211>  120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  86
gcccaccagc agaaggtgaa ctttgtccct ccccatccat cctccatgcc tgtcactgcc     60

gccgccttct ttggagccgc atcacaatac tggacctccc ccacgggggg aatctacccc    120


<210>  87
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  87
gtgcacggca aaagatatgc ttac                                            24


<210>  88
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  88
ctagtagtag ctgcctaagt gtg                                             23


<210>  89
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  89
caccgagact tgttcggtcc acgg                                            24


<210>  90
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  90
aaacccgtcc accgaacaaa gtctc                                           25


<210>  91
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  91
caccgtgctg cccaacactc agccg                                           25


<210>  92
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  92
aaaccggctg agtgttggga gcac                                            24


<210>  93
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  93
cacgcagacc aggttctgcc cccg                                            24


<210>  94
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  94
aaaccggggg cagaacctgg tctgc                                           25


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Pro Val Thr Ser Ser Ser Phe Phe 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Thr Ala Ser Ser Ser Ser Asp Tyr 
1               5                   


<210>  97
<211>  8
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, t or u

<400>  97
gmvsstsn                                                               8


<210>  98
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  98

Pro Val Ala Asp Ser Ser Thr Arg Val 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Glu Ala Ser Ser Thr Thr Ser Pro 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Val Ser Glu Gly Ser Ser Ser Gly Arg 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Gln Pro Ser Ser Thr Ser Gly Gly 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Asp Val Ser Ser Ser Thr His Pro 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Pro Val Thr Ala Ala Ala Phe Phe 
1               5                   


