                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> EXOSOME-BASED CANCER ASSAYS

<130> 701586-099990WOPT

<140>
<141>

<150> 63/277,766
<151> 2021-11-10

<150> 63/171,689
<151> 2021-04-07

<160> 130   

<170> PatentIn version 3.5

<210> 1
<211> 72
<212> RNA
<213> Homo sapiens

<400> 1
uacaucggcc auuauaauac aaccugauaa guguuauagc acuuaucaga uuguauugua       60

auugucugug ua                                                           72


<210> 2
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2
caaagugcug uucgugcagg uag                                               23


<210> 3
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3
cacuagauug ugagcuccug ga                                                22


<210> 4
<211> 83
<212> RNA
<213> Homo sapiens

<400> 4
cggggugagg uaguagguug ugugguuuca gggcagugau guugccccuc ggaagauaac       60

uauacaaccu acugccuucc cug                                               83


<210> 5
<211> 64
<212> RNA
<213> Homo sapiens

<400> 5
ccccgcgacg agccccucgc acaaaccgga ccugagcguu uuguucguuc ggcucgcgug       60

aggc                                                                    64


<210> 6
<211> 22
<212> RNA
<213> Homo sapiens

<400> 6
cagcagcaau ucauguuuug aa                                                22


<210> 7
<211> 95
<212> RNA
<213> Homo sapiens

<400> 7
cucaucuguc uguugggcug gaggcagggc cuuugugaag gcggguggug cucagaucgc       60

cucugggccc uuccuccagc cccgaggcgg auuca                                  95


<210> 8
<211> 21
<212> RNA
<213> Homo sapiens

<400> 8
uucacagugg cuaaguuccg c                                                 21


<210> 9
<211> 22
<212> RNA
<213> Homo sapiens

<400> 9
aaaagcuggg uugagagggc aa                                                22


<210> 10
<211> 20
<212> RNA
<213> Homo sapiens

<400> 10
aaaagcuggg uugagagggu                                                   20


<210> 11
<211> 19
<212> RNA
<213> Homo sapiens

<400> 11
aaaagcuggg uugagagga                                                    19


<210> 12
<211> 2452
<212> DNA
<213> Homo sapiens

<400> 12
agaaagcgag cagccaccca gctccccgcc accgccatgg tccccgacac cgcctgcgtt       60

cttctgctca ccctggctgc cctcggcgcg tccggacagg gccagagccc gttgggctca      120

gacctgggcc cgcagatgct tcgggaactg caggaaacca acgcggcgct gcaggacgtg      180

cgggagctgc tgcggcagca ggtcagggag atcacgttcc tgaaaaacac ggtgatggag      240

tgtgacgcgt gcgggatgca gcagtcagta cgcaccggcc tacccagcgt gcggcccctg      300

ctccactgcg cgcccggctt ctgcttcccc ggcgtggcct gcatccagac ggagagcggc      360

gcgcgctgcg gcccctgccc cgcgggcttc acgggcaacg gctcgcactg caccgacgtc      420

aacgagtgca acgcccaccc ctgcttcccc cgagtccgct gtatcaacac cagcccgggg      480

ttccgctgcg aggcttgccc gccggggtac agcggcccca cccaccaggg cgtggggctg      540

gctttcgcca aggccaacaa gcaggtttgc acggacatca acgagtgtga gaccgggcaa      600

cataactgcg tccccaactc cgtgtgcatc aacacccggg gctccttcca gtgcggcccg      660

tgccagcccg gcttcgtggg cgaccaggcg tccggctgcc agcggcgcgc acagcgcttc      720

tgccccgacg gctcgcccag cgagtgccac gagcatgcag actgcgtcct agagcgcgat      780

ggctcgcggt cgtgcgtgtg tgccgttggc tgggccggca acgggatcct ctgtggtcgc      840

gacactgacc tagacggctt cccggacgag aagctgcgct gcccggagcg ccagtgccgt      900

aaggacaact gcgtgactgt gcccaactca gggcaggagg atgtggaccg cgatggcatc      960

ggagacgcct gcgatccgga tgccgacggg gacggggtcc ccaatgaaaa ggacaactgc     1020

ccgctggtgc ggaacccaga ccagcgcaac acggacgagg acaagtgggg cgatgcgtgc     1080

gacaactgcc ggtcccagaa gaacgacgac caaaaggaca cagaccagga cggccggggc     1140

gatgcgtgcg acgacgacat cgacggcgac cggatccgca accaggccga caactgccct     1200

agggtaccca actcagacca gaaggacagt gatggcgatg gtatagggga tgcctgtgac     1260

aactgtcccc agaagagcaa cccggatcag gcggatgtgg accacgactt tgtgggagat     1320

gcttgtgaca gcgatcaaga ccaggatgga gacggacatc aggactctcg ggacaactgt     1380

cccacggtgc ctaacagtgc ccaggaggac tcagaccacg atggccaggg tgatgcctgc     1440

gacgacgacg acgacaatga cggagtccct gacagtcggg acaactgccg cctggtgcct     1500

aaccccggcc aggaggacgc ggacagggac ggcgtgggcg acgtgtgcca ggacgacttt     1560

gatgcagaca aggtggtaga caagatcgac gtgtgtccgg agaacgctga agtcacgctc     1620

accgacttca gggccttcca gacagtcgtg ctggacccgg agggtgacgc gcagattgac     1680

cccaactggg tggtgctcaa ccagggaagg gagatcgtgc agacaatgaa cagcgaccca     1740

ggcctggctg tgggttacac tgccttcaat ggcgtggact tcgagggcac gttccatgtg     1800

aacacggtca cggatgacga ctatgcgggc ttcatctttg gctaccagga cagctccagc     1860

ttctacgtgg tcatgtggaa gcagatggag caaacgtatt ggcaggcgaa ccccttccgt     1920

gctgtggccg agcctggcat ccaactcaag gctgtgaagt cttccacagg ccccggggaa     1980

cagctgcgga acgctctgtg gcatacagga gacacagagt cccaggtgcg gctgctgtgg     2040

aaggacccgc gaaacgtggg ttggaaggac aagaagtcct atcgttggtt cctgcagcac     2100

cggccccaag tgggctacat cagggtgcga ttctatgagg gccctgagct ggtggccgac     2160

agcaacgtgg tcttggacac aaccatgcgg ggtggccgcc tgggggtctt ctgcttctcc     2220

caggagaaca tcatctgggc caacctgcgt taccgctgca atgacaccat cccagaggac     2280

tatgagaccc atcagctgcg gcaagcctag ggaccagggt gaggacccgc cggatgacag     2340

ccaccctcac cgcggctgga tgggggctct gcacccagcc ccaaggggtg gccgtcctga     2400

gggggaagtg agaagggctc agagaggaca aaataaagtg tgtgtgcagg ga             2452


<210> 13
<211> 757
<212> PRT
<213> Homo sapiens

<400> 13
Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210> 14
<211> 1705
<212> DNA
<213> Homo sapiens

<400> 14
attgcgccgc ggcacggcct agcgagtggt tcttctgcgc tactgctgcg cgaatcggcg       60

accccagtgc ctcgaccact atgccgcgct ctttcctcgt caggaagccc tccgacccca      120

atcggaagcc taactacagc gagctgcagg actctaatcc agagtttacc ttccagcagc      180

cctacgacca ggcccacctg ctggcagcca tcccacctcc ggagatcctc aaccccaccg      240

cctcgctgcc aatgctcatc tgggactctg tcctggcgcc ccaagcccag ccaattgcct      300

gggcctccct tcggctccag gagagtccca gggtggcaga gctgacctcc ctgtcagatg      360

aggacagtgg gaaaggctcc cagcccccca gcccaccctc accggctcct tcgtccttct      420

cctctacttc agtctcttcc ttggaggccg aggcctatgc tgccttccca ggcttgggcc      480

aagtgcccaa gcagctggcc cagctctctg aggccaagga tctccaggct cgaaaggcct      540

tcaactgcaa atactgcaac aaggaatacc tcagcctggg tgccctcaag atgcacatcc      600

gaagccacac gctgccctgc gtctgcggaa cctgcgggaa ggccttctct aggccctggc      660

tgctacaagg ccatgtccgg acccacactg gcgagaagcc cttctcctgt ccccactgca      720

gccgtgcctt cgctgaccgc tccaacctgc gggcccacct ccagacccac tcagatgtca      780

agaagtacca gtgccaggcg tgtgctcgga ccttctcccg aatgtccctg ctccacaagc      840

accaagagtc cggctgctca ggatgtcccc gctgaccctc gaggctccct cttcctctcc      900

atacctgccc ctgcctgaca gccttcccca gctccagcag gaaggacccc acatccttct      960

cactgccatg gaattccctc ctgagtgccc cacttctggc cacatcagcc ccacaggact     1020

ttgatgaaga ccattttctg gttctgtgtc ctctgcctgg gctctggaag aggccttccc     1080

atggccattt ctgtggaggg agggcagctg gcccccagcc ctgggggatt cctgagctgg     1140

cctgtctgcg tgggtttttg tatccagagc tgtttggata cagctgcttt gagctacagg     1200

acaaaggctg acagactcac tgggaagctc ccaccccact caggggaccc cactcccctc     1260

acacacaccc ccccacaagg aaccctcagg ccaccctcca cgaggtgtga ctaactatgc     1320

aataatccac ccccaggtgc agccccaggg cctgcggagg cggtggcaga ctagagtctg     1380

agatgccccg agcccaggca gctatttcag cctcctgttt ggtggggtgg cacctgtttc     1440

ccgggcaatt taacaatgtc tgaaaaggga ctgtgagtaa tggctgtcac ttgtcggggg     1500

cccaagtggg gtgctctggt ctgaccgatg tgtctcccag aactattctg ggggcccgac     1560

aggtgggcct gggaggaaga tgtttacatt tttaaaggta cactggtatt tatatttcaa     1620

acattttgta tcaaggaaac gttttgtata gttatatgta cagtttattg atattcaata     1680

aagcagttaa tttatatatt aaaaa                                           1705


<210> 15
<211> 264
<212> PRT
<213> Homo sapiens

<400> 15
Met Pro Arg Ser Phe Leu Val Arg Lys Pro Ser Asp Pro Asn Arg Lys 
1               5                   10                  15      


Pro Asn Tyr Ser Glu Leu Gln Asp Ser Asn Pro Glu Phe Thr Phe Gln 
            20                  25                  30          


Gln Pro Tyr Asp Gln Ala His Leu Leu Ala Ala Ile Pro Pro Pro Glu 
        35                  40                  45              


Ile Leu Asn Pro Thr Ala Ser Leu Pro Met Leu Ile Trp Asp Ser Val 
    50                  55                  60                  


Leu Ala Pro Gln Ala Gln Pro Ile Ala Trp Ala Ser Leu Arg Leu Gln 
65                  70                  75                  80  


Glu Ser Pro Arg Val Ala Glu Leu Thr Ser Leu Ser Asp Glu Asp Ser 
                85                  90                  95      


Gly Lys Gly Ser Gln Pro Pro Ser Pro Pro Ser Pro Ala Pro Ser Ser 
            100                 105                 110         


Phe Ser Ser Thr Ser Val Ser Ser Leu Glu Ala Glu Ala Tyr Ala Ala 
        115                 120                 125             


Phe Pro Gly Leu Gly Gln Val Pro Lys Gln Leu Ala Gln Leu Ser Glu 
    130                 135                 140                 


Ala Lys Asp Leu Gln Ala Arg Lys Ala Phe Asn Cys Lys Tyr Cys Asn 
145                 150                 155                 160 


Lys Glu Tyr Leu Ser Leu Gly Ala Leu Lys Met His Ile Arg Ser His 
                165                 170                 175     


Thr Leu Pro Cys Val Cys Gly Thr Cys Gly Lys Ala Phe Ser Arg Pro 
            180                 185                 190         


Trp Leu Leu Gln Gly His Val Arg Thr His Thr Gly Glu Lys Pro Phe 
        195                 200                 205             


Ser Cys Pro His Cys Ser Arg Ala Phe Ala Asp Arg Ser Asn Leu Arg 
    210                 215                 220                 


Ala His Leu Gln Thr His Ser Asp Val Lys Lys Tyr Gln Cys Gln Ala 
225                 230                 235                 240 


Cys Ala Arg Thr Phe Ser Arg Met Ser Leu Leu His Lys His Gln Glu 
                245                 250                 255     


Ser Gly Cys Ser Gly Cys Pro Arg 
            260                 


<210> 16
<211> 1107
<212> DNA
<213> Homo sapiens

<400> 16
aactcccaga cacctcgcgg gctctgcagc accggcaccg tttccaggag gcctggcggg       60

gtgtgcgtcc agccgttggg cgctttcttt ttggacctcg gggccatcca caccgtcccc      120

tccccctccc gcctccctcc ccgcctcccc cgcgcgccct ccccgcggag gtccctcccg      180

tccgtcctcc tgctctctcc tccgcgggcc gcatcgcccg ggccggcgcc gcgcgcgggg      240

gaagctggcg ggctgaggcg ccccgctctt ctcctctgcc ccgggcccgc gaggccacgc      300

gtcgccgctc gagagatgat gcaggacgtg tccagctcgc cagtctcgcc ggccgacgac      360

agcctgagca acagcgagga agagccagac cggcagcagc cgccgagcgg caagcgcggg      420

ggacgcaagc ggcgcagcag caggcgcagc gcgggcggcg gcgcggggcc cggcggagcc      480

gcgggtgggg gcgtcggagg cggcgacgag ccgggcagcc cggcccaggg caagcgcggc      540

aagaagtctg cgggctgtgg cggcggcggc ggcgcgggcg gcggcggcgg cagcagcagc      600

ggcggcggga gtccgcagtc ttacgaggag ctgcagacgc agcgggtcat ggccaacgtg      660

cgggagcgcc agcgcaccca gtcgctgaac gaggcgttcg ccgcgctgcg gaagatcatc      720

cccacgctgc cctcggacaa gctgagcaag attcagaccc tcaagctggc ggccaggtac      780

atcgacttcc tctaccaggt cctccagagc gacgagctgg actccaagat ggcaagctgc      840

agctatgtgg ctcacgagcg gctcagctac gccttctcgg tctggaggat ggagggggcc      900

tggtccatgt ccgcgtccca ctagcaggcg gagcccccca ccccctcagc agggccggag      960

acctagattt cttaaggtac accaggatgg agctggccat gactgctgag aagaagcaca     1020

tgtccagatg ataattcacg cacagttaca ggttcccctc cccaaagtgg aacgtattat     1080

taataaaata atgttaagga gcagaaa                                         1107


<210> 17
<211> 1630
<212> DNA
<213> Homo sapiens

<400> 17
aactcccaga cacctcgcgg gctctgcagc accggcaccg tttccaggag gcctggcggg       60

gtgtgcgtcc agccgttggg cgctttcttt ttggacctcg gggccatcca caccgtcccc      120

tccccctccc gcctccctcc ccgcctcccc cgcgcgccct ccccgcggag gtccctcccg      180

tccgtcctcc tgctctctcc tccgcgggcc gcatcgcccg ggccggcgcc gcgcgcgggg      240

gaagctggcg ggctgaggcg ccccgctctt ctcctctgcc ccgggcccgc gaggccacgc      300

gtcgccgctc gagagatgat gcaggacgtg tccagctcgc cagtctcgcc ggccgacgac      360

agcctgagca acagcgagga agagccagac cggcagcagc cgccgagcgg caagcgcggg      420

ggacgcaagc ggcgcagcag caggcgcagc gcgggcggcg gcgcggggcc cggcggagcc      480

gcgggtgggg gcgtcggagg cggcgacgag ccgggcagcc cggcccaggg caagcgcggc      540

aagaagtctg cgggctgtgg cggcggcggc ggcgcgggcg gcggcggcgg cagcagcagc      600

ggcggcggga gtccgcagtc ttacgaggag ctgcagacgc agcgggtcat ggccaacgtg      660

cgggagcgcc agcgcaccca gtcgctgaac gaggcgttcg ccgcgctgcg gaagatcatc      720

cccacgctgc cctcggacaa gctgagcaag attcagaccc tcaagctggc ggccaggtac      780

atcgacttcc tctaccaggt cctccagagc gacgagctgg actccaagat ggcaagctgc      840

agctatgtgg ctcacgagcg gctcagctac gccttctcgg tctggaggat ggagggggcc      900

tggtccatgt ccgcgtccca ctagcaggcg gagcccccca ccccctcagc agggccggag      960

acctagatgt cattgtttcc agagaaggag aaaatggaca gtctagagac tctggagctg     1020

gataactaaa aataaaaata tatgccaaag attttcttgg aaattagaag agcaaaatcc     1080

aaattcaaag aaacagggcg tggggcgcac ttttaaaaga gaaagcgaga caggcccgtg     1140

gacagtgatt cccagacggg cagcggcacc atcctcacac ctctgcattc tgatagaagt     1200

ctgaacagtt gtttgtgttt tttttttttt tttttttgac gaagaatgtt tttattttta     1260

tttttttcat gcatgcattc tcaagaggtc gtgccaatca gccactgaaa ggaaaggcat     1320

cactatggac tttctctatt ttaaaatggt aacaatcaga ggaactataa gaacaccttt     1380

agaaataaaa atactgggat caaactggcc tgcaaaacca tagtcagtta attctttttt     1440

tcatccttcc tctgagggga aaaacaaaaa aaaacttaaa atacaaaaaa caacattcta     1500

tttatttatt gaggacccat ggtaaaatgc aaatagatcc ggtgtctaaa tgcattcata     1560

tttttatgat tgttttgtaa atatctttgt atatttttct gcaataaata aatataaaaa     1620

atttagagaa                                                            1630


<210> 18
<211> 202
<212> PRT
<213> Homo sapiens

<400> 18
Met Met Gln Asp Val Ser Ser Ser Pro Val Ser Pro Ala Asp Asp Ser 
1               5                   10                  15      


Leu Ser Asn Ser Glu Glu Glu Pro Asp Arg Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Lys Arg Gly Gly Arg Lys Arg Arg Ser Ser Arg Arg Ser Ala Gly Gly 
        35                  40                  45              


Gly Ala Gly Pro Gly Gly Ala Ala Gly Gly Gly Val Gly Gly Gly Asp 
    50                  55                  60                  


Glu Pro Gly Ser Pro Ala Gln Gly Lys Arg Gly Lys Lys Ser Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Ser Ser Gly 
                85                  90                  95      


Gly Gly Ser Pro Gln Ser Tyr Glu Glu Leu Gln Thr Gln Arg Val Met 
            100                 105                 110         


Ala Asn Val Arg Glu Arg Gln Arg Thr Gln Ser Leu Asn Glu Ala Phe 
        115                 120                 125             


Ala Ala Leu Arg Lys Ile Ile Pro Thr Leu Pro Ser Asp Lys Leu Ser 
    130                 135                 140                 


Lys Ile Gln Thr Leu Lys Leu Ala Ala Arg Tyr Ile Asp Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Gln Ser Asp Glu Leu Asp Ser Lys Met Ala Ser Cys Ser 
                165                 170                 175     


Tyr Val Ala His Glu Arg Leu Ser Tyr Ala Phe Ser Val Trp Arg Met 
            180                 185                 190         


Glu Gly Ala Trp Ser Met Ser Ala Ser His 
        195                 200         


<210> 19
<211> 2180
<212> DNA
<213> Homo sapiens

<400> 19
agttcgtaaa ggagccgggt gacttcagag gcgccggccc gtccgtctgc cgcacctgag       60

cacggcccct gcccgagcct ggcccgccgc gatgctgtag ggaccgccgt gtcctcccgc      120

cggaccgtta tccgcgccgg gcgcccgcca gacccgctgg caagatgccg cgctccttcc      180

tggtcaagaa gcatttcaac gcctccaaaa agccaaacta cagcgaactg gacacacata      240

cagtgattat ttccccgtat ctctatgaga gttactccat gcctgtcata ccacaaccag      300

agatcctcag ctcaggagca tacagcccca tcactgtgtg gactaccgct gctccattcc      360

acgcccagct acccaatggc ctctctcctc tttccggata ctcctcatct ttggggcgag      420

tgagtccccc tcctccatct gacacctcct ccaaggacca cagtggctca gaaagcccca      480

ttagtgatga agaggaaaga ctacagtcca agctttcaga cccccatgcc attgaagctg      540

aaaagtttca gtgcaattta tgcaataaga cctattcaac tttttctggg ctggccaaac      600

ataagcagct gcactgcgat gcccagtcta gaaaatcttt cagctgtaaa tactgtgaca      660

aggaatatgt gagcctgggc gccctgaaga tgcatattcg gacccacaca ttaccttgtg      720

tttgcaagat ctgcggcaag gcgttttcca gaccctggtt gcttcaagga cacattagaa      780

ctcacacggg ggagaagcct ttttcttgcc ctcactgcaa cagagcattt gcagacaggt      840

caaatctgag ggctcatctg cagacccatt ctgatgtaaa gaaataccag tgcaaaaact      900

gctccaaaac cttctccaga atgtctctcc tgcacaaaca tgaggaatct ggctgctgtg      960

tagcacactg agtgacgcaa tcaatgttta ctcgaacaga atgcatttct tcactccgaa     1020

gccaaatgac aaataaagtc caaaggcatt ttctcctgtg ctgaccaacc aaataatatg     1080

tatagacaca cacacatatg cacacacaca cacacacacc cacagagaga gagctgcaag     1140

agcatggaat tcatgtgttt aaagataatc ctttccatgt gaagtttaaa attactatat     1200

atttgctgat ggctagattg agagaataaa agacagtaac ctttctcttc aaagataaaa     1260

tgaaaagcac attgcatctt ttcttcctaa aaaaatgcaa agatttacat tgctgccaaa     1320

tcatttcaac tgaaaagaac agtattgctt tgtaatagag tctgtaatag gatttcccat     1380

aggaagagat ctgccagacg cgaactcagg tgccttaaaa agtattccaa gtttactcca     1440

ttacatgtcg gttgtctggt tgccattgtt gaactaaagc ctttttttga ttacctgtag     1500

tgctttaaag tatattttta aaagggagga aaaaaataac aagaacaaaa cacaggagaa     1560

tgtattaaaa gtatttttgt tttgttttgt ttttgccaat taacagtatg tgccttgggg     1620

gaggagggaa agattagctt tgaacattcc tggcgcatgc tccattgtct tactatttta     1680

aaacatttta ataatttttg aaaattaatt aaagatggga ataagtgcaa aagaggattc     1740

ttacaaattc attaatgtac ttaaactatt tcaaatgcat accacaaatg caataataca     1800

ataccccttc caagtgcctt tttaaattgt atagttgatg agtcaatgta aatttgtgtt     1860

tatttttata tgattgaatg agttctgtat gaaactgaga tgttgtctat agctatgtct     1920

ataaacaacc tgaagacttg tgaaatcaat gtttcttttt taaaaaacaa ttttcaagtt     1980

ttttttacaa taaacagttt tgatttaaaa tctcgtttgt atactatttt cagagacttt     2040

acttgcttca tgattagtac caaaccactg tacaaagaat tgtttgttaa caagaaaaaa     2100

atgaataatg cttattatgc atctgaagtg ttattttatg tgttagatta taataaagta     2160

agctgctagt attattttta                                                 2180


<210> 20
<211> 268
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Arg Ser Phe Leu Val Lys Lys His Phe Asn Ala Ser Lys Lys 
1               5                   10                  15      


Pro Asn Tyr Ser Glu Leu Asp Thr His Thr Val Ile Ile Ser Pro Tyr 
            20                  25                  30          


Leu Tyr Glu Ser Tyr Ser Met Pro Val Ile Pro Gln Pro Glu Ile Leu 
        35                  40                  45              


Ser Ser Gly Ala Tyr Ser Pro Ile Thr Val Trp Thr Thr Ala Ala Pro 
    50                  55                  60                  


Phe His Ala Gln Leu Pro Asn Gly Leu Ser Pro Leu Ser Gly Tyr Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Arg Val Ser Pro Pro Pro Pro Ser Asp Thr Ser Ser 
                85                  90                  95      


Lys Asp His Ser Gly Ser Glu Ser Pro Ile Ser Asp Glu Glu Glu Arg 
            100                 105                 110         


Leu Gln Ser Lys Leu Ser Asp Pro His Ala Ile Glu Ala Glu Lys Phe 
        115                 120                 125             


Gln Cys Asn Leu Cys Asn Lys Thr Tyr Ser Thr Phe Ser Gly Leu Ala 
    130                 135                 140                 


Lys His Lys Gln Leu His Cys Asp Ala Gln Ser Arg Lys Ser Phe Ser 
145                 150                 155                 160 


Cys Lys Tyr Cys Asp Lys Glu Tyr Val Ser Leu Gly Ala Leu Lys Met 
                165                 170                 175     


His Ile Arg Thr His Thr Leu Pro Cys Val Cys Lys Ile Cys Gly Lys 
            180                 185                 190         


Ala Phe Ser Arg Pro Trp Leu Leu Gln Gly His Ile Arg Thr His Thr 
        195                 200                 205             


Gly Glu Lys Pro Phe Ser Cys Pro His Cys Asn Arg Ala Phe Ala Asp 
    210                 215                 220                 


Arg Ser Asn Leu Arg Ala His Leu Gln Thr His Ser Asp Val Lys Lys 
225                 230                 235                 240 


Tyr Gln Cys Lys Asn Cys Ser Lys Thr Phe Ser Arg Met Ser Leu Leu 
                245                 250                 255     


His Lys His Glu Glu Ser Gly Cys Cys Val Ala His 
            260                 265             


<210> 21
<211> 2154
<212> DNA
<213> Homo sapiens

<400> 21
gggaggccca cgtatggcgc ctctccaaag gctgcagaag tttcttgcta acaaaaagtc       60

cgcacattcg agcaaagaca ggctttagcg agttattaaa aacttagggg cgctcttgtc      120

ccccacaggg cccgaccgca cacagcaagg cgatggccca gctgtaagtt ggtagcactg      180

agaactagca gcgcgcgcgg agcccgctga gacttgaatc aatctggtct aacggtttcc      240

cctaaaccgc taggagccct caatcggcgg gacagcaggg cgcgtcctct gccactctcg      300

ctccgaggtc cccgcgccag agacgcagcc gcgctcccac cacccacacc caccgcgccc      360

tcgttcgcct cttctccggg agccagtccg cgccaccgcc gccgcccagg ccatcgccac      420

cctccgcagc catgtccacc aggtccgtgt cctcgtcctc ctaccgcagg atgttcggcg      480

gcccgggcac cgcgagccgg ccgagctcca gccggagcta cgtgactacg tccacccgca      540

cctacagcct gggcagcgcg ctgcgcccca gcaccagccg cagcctctac gcctcgtccc      600

cgggcggcgt gtatgccacg cgctcctctg ccgtgcgcct gcggagcagc gtgcccgggg      660

tgcggctcct gcaggactcg gtggacttct cgctggccga cgccatcaac accgagttca      720

agaacacccg caccaacgag aaggtggagc tgcaggagct gaatgaccgc ttcgccaact      780

acatcgacaa ggtgcgcttc ctggagcagc agaataagat cctgctggcc gagctcgagc      840

agctcaaggg ccaaggcaag tcgcgcctgg gggacctcta cgaggaggag atgcgggagc      900

tgcgccggca ggtggaccag ctaaccaacg acaaagcccg cgtcgaggtg gagcgcgaca      960

acctggccga ggacatcatg cgcctccggg agaaattgca ggaggagatg cttcagagag     1020

aggaagccga aaacaccctg caatctttca gacaggatgt tgacaatgcg tctctggcac     1080

gtcttgacct tgaacgcaaa gtggaatctt tgcaagaaga gattgccttt ttgaagaaac     1140

tccacgaaga ggaaatccag gagctgcagg ctcagattca ggaacagcat gtccaaatcg     1200

atgtggatgt ttccaagcct gacctcacgg ctgccctgcg tgacgtacgt cagcaatatg     1260

aaagtgtggc tgccaagaac ctgcaggagg cagaagaatg gtacaaatcc aagtttgctg     1320

acctctctga ggctgccaac cggaacaatg acgccctgcg ccaggcaaag caggagtcca     1380

ctgagtaccg gagacaggtg cagtccctca cctgtgaagt ggatgccctt aaaggaacca     1440

atgagtccct ggaacgccag atgcgtgaaa tggaagagaa ctttgccgtt gaagctgcta     1500

actaccaaga cactattggc cgcctgcagg atgagattca gaatatgaag gaggaaatgg     1560

ctcgtcacct tcgtgaatac caagacctgc tcaatgttaa gatggccctt gacattgaga     1620

ttgccaccta caggaagctg ctggaaggcg aggagagcag gatttctctg cctcttccaa     1680

acttttcctc cctgaacctg agggaaacta atctggattc actccctctg gttgataccc     1740

actcaaaaag gacacttctg attaagacgg ttgaaactag agatggacag gttatcaacg     1800

aaacttctca gcatcacgat gaccttgaat aaaaattgca cacactcagt gcagcaatat     1860

attaccagca agaataaaaa agaaatccat atcttaaaga aacagctttc aagtgccttt     1920

ctgcagtttt tcaggagcgc aagatagatt tggaatagga ataagctcta gttcttaaca     1980

accgacactc ctacaagatt tagaaaaaag tttacaacat aatctagttt acagaaaaat     2040

cttgtgctag aatacttttt aaaaggtatt ttgaatacca ttaaaactgc tttttttttt     2100

ccagcaagta tccaaccaac ttggttctgc ttcaataaat ctttggaaaa actc           2154


<210> 22
<211> 466
<212> PRT
<213> Homo sapiens

<400> 22
Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210> 23
<211> 1873
<212> DNA
<213> Homo sapiens

<400> 23
cagtcctctg ccactctcgc tccgaggtcc ccgcgccaga gacgcagccg cgctcccacc       60

acccacaccc accgcgccct cgttcgcctc ttctccggga gccagtccgc gccaccgccg      120

ccgcccaggc catcgccacc ctccgcagcc atgtccacca ggtccgtgtc ctcgtcctcc      180

taccgcagga tgttcggcgg cccgggcacc gcgagccggc cgagctccag ccggagctac      240

gtgactacgt ccacccgcac ctacagcctg ggcagcgcgc tgcgccccag caccagccgc      300

agcctctacg cctcgtcccc gggcggcgtg tatgccacgc gctcctctgc cgtgcgcctg      360

cggagcagcg tgcccggggt gcggctcctg caggactcgg tggacttctc gctggccgac      420

gccatcaaca ccgagttcaa gaacacccgc accaacgaga aggtggagct gcaggagctg      480

aatgaccgct tcgccaacta catcgacaag gtgcgcttcc tggagcagca gaataagatc      540

ctgctggccg agctcgagca gctcaagggc caaggcaagt cgcgcctggg ggacctctac      600

gaggaggaga tgcgggagct gcgccggcag gtggaccagc taaccaacga caaagcccgc      660

gtcgaggtgg agcgcgacaa cctggccgag gacatcatgc gcctccggga gaaattgcag      720

gaggagatgc ttcagagaga ggaagccgaa aacaccctgc aatctttcag acaggatgtt      780

gacaatgcgt ctctggcacg tcttgacctt gaacgcaaag tggaatcttt gcaagaagag      840

attgcctttt tgaagaaact ccacgaagag gaaatccagg agctgcaggc tcagattcag      900

gaacagcatg tccaaatcga tgtggatgtt tccaagcctg acctcacggc tgccctgcgt      960

gacgtacgtc agcaatatga aagtgtggct gccaagaacc tgcaggaggc agaagaatgg     1020

tacaaatcca agtttgctga cctctctgag gctgccaacc ggaacaatga cgccctgcgc     1080

caggcaaagc aggagtccac tgagtaccgg agacaggtgc agtccctcac ctgtgaagtg     1140

gatgccctta aaggaaccaa tgagtccctg gaacgccaga tgcgtgaaat ggaagagaac     1200

tttgccgttg aagctgctaa ctaccaagac actattggcc gcctgcagga tgagattcag     1260

aatatgaagg aggaaatggc tcgtcacctt cgtgaatacc aagacctgct caatgttaag     1320

atggcccttg acattgagat tgccacctac aggaagctgc tggaaggcga ggagagcagg     1380

atttctctgc ctcttccaaa cttttcctcc ctgaacctga gggaaactaa tctggattca     1440

ctccctctgg ttgataccca ctcaaaaagg acacttctga ttaagacggt tgaaactaga     1500

gatggacagg ttatcaacga aacttctcag catcacgatg accttgaata aaaattgcac     1560

acactcagtg cagcaatata ttaccagcaa gaataaaaaa gaaatccata tcttaaagaa     1620

acagctttca agtgcctttc tgcagttttt caggagcgca agatagattt ggaataggaa     1680

taagctctag ttcttaacaa ccgacactcc tacaagattt agaaaaaagt ttacaacata     1740

atctagttta cagaaaaatc ttgtgctaga atacttttta aaaggtattt tgaataccat     1800

taaaactgct tttttttttc cagcaagtat ccaaccaact tggttctgct tcaataaatc     1860

tttggaaaaa ctc                                                        1873


<210> 24
<211> 466
<212> PRT
<213> Homo sapiens

<400> 24
Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210> 25
<211> 4628
<212> DNA
<213> Homo sapiens

<400> 25
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gggcttggat tttgaggcca agcagcagta cattctacac gtagcagtga cgaatgtggt     1320

accttttgag gtctctctca ccacctccac agccaccgtc accgtggatg tgctggatgt     1380

gaatgaagcc cccatctttg tgcctcctga aaagagagtg gaagtgtccg aggactttgg     1440

cgtgggccag gaaatcacat cctacactgc ccaggagcca gacacattta tggaacagaa     1500

aataacatat cggatttgga gagacactgc caactggctg gagattaatc cggacactgg     1560

tgccatttcc actcgggctg agctggacag ggaggatttt gagcacgtga agaacagcac     1620

gtacacagcc ctaatcatag ctacagacaa tggttctcca gttgctactg gaacagggac     1680

acttctgctg atcctgtctg atgtgaatga caacgccccc ataccagaac ctcgaactat     1740

attcttctgt gagaggaatc caaagcctca ggtcataaac atcattgatg cagaccttcc     1800

tcccaataca tctcccttca cagcagaact aacacacggg gcgagtgcca actggaccat     1860

tcagtacaac gacccaaccc aagaatctat cattttgaag ccaaagatgg ccttagaggt     1920

gggtgactac aaaatcaatc tcaagctcat ggataaccag aataaagacc aagtgaccac     1980

cttagaggtc agcgtgtgtg actgtgaagg ggccgctggc gtctgtagga aggcacagcc     2040

tgtcgaagca ggattgcaaa ttcctgccat tctggggatt cttggaggaa ttcttgcttt     2100

gctaattctg attctgctgc tcttgctgtt tcttcggagg agagcggtgg tcaaagagcc     2160

cttactgccc ccagaggatg acacccggga caacgtttat tactatgatg aagaaggagg     2220

cggagaagag gaccaggact ttgacttgag ccagctgcac aggggcctgg acgctcggcc     2280

tgaagtgact cgtaacgacg ttgcaccaac cctcatgagt gtcccccggt atcttccccg     2340

ccctgccaat cccgatgaaa ttggaaattt tattgatgaa aatctgaaag cggctgatac     2400

tgaccccaca gccccgcctt atgattctct gctcgtgttt gactatgaag gaagcggttc     2460

cgaagctgct agtctgagct ccctgaactc ctcagagtca gacaaagacc aggactatga     2520

ctacttgaac gaatggggca atcgcttcaa gaagctggct gacatgtacg gaggcggcga     2580

ggacgactag gggactcgag agaggcgggc cccagaccca tgtgctggga aatgcagaaa     2640

tcacgttgct ggtggttttt cagctccctt cccttgagat gagtttctgg ggaaaaaaaa     2700

gagactggtt agtgatgcag ttagtatagc tttatactct ctccacttta tagctctaat     2760

aagtttgtgt tagaaaagtt tcgacttatt tcttaaagct tttttttttt tcccatcact     2820

ctttacatgg tggtgatgtc caaaagatac ccaaatttta atattccaga agaacaactt     2880

tagcatcaga aggttcaccc agcaccttgc agattttctt aaggaatttt gtctcacttt     2940

taaaaagaag gggagaagtc agctactcta gttctgttgt tttgtgtata taatttttta     3000

aaaaaaattt gtgtgcttct gctcattact acactggtgt gtccctctgc cttttttttt     3060

tttttaagac agggtctcat tctatcggcc aggctggagt gcagtggtgc aatcacagct     3120

cactgcagcc ttgtcctccc aggctcaagc tatccttgca cctcagcctc ccaagtagct     3180

gggaccacag gcatgcacca ctacgcatga ctaatttttt aaatatttga gacggggtct     3240

ccctgtgtta cccaggctgg tctcaaactc ctgggctcaa gtgatcctcc catcttggcc     3300

tcccagagta ttgggattac agacatgagc cactgcacct gcccagctcc ccaactccct     3360

gccatttttt aagagacagt ttcgctccat cgcccaggcc tgggatgcag tgatgtgatc     3420

atagctcact gtaacctcaa actctggggc tcaagcagtt ctcccaccag cctccttttt     3480

atttttttgt acagatgggg tcttgctatg ttgcccaagc tggtcttaaa ctcctggcct     3540

caagcaatcc ttctgccttg gccccccaaa gtgctgggat tgtgggcatg agctgctgtg     3600

cccagcctcc atgttttaat atcaactctc actcctgaat tcagttgctt tgcccaagat     3660

aggagttctc tgatgcagaa attattgggc tcttttaggg taagaagttt gtgtctttgt     3720

ctggccacat cttgactagg tattgtctac tctgaagacc tttaatggct tccctctttc     3780

atctcctgag tatgtaactt gcaatgggca gctatccagt gacttgttct gagtaagtgt     3840

gttcattaat gtttatttag ctctgaagca agagtgatat actccaggac ttagaatagt     3900

gcctaaagtg ctgcagccaa agacagagcg gaactatgaa aagtgggctt ggagatggca     3960

ggagagcttg tcattgagcc tggcaattta gcaaactgat gctgaggatg attgaggtgg     4020

gtctacctca tctctgaaaa ttctggaagg aatggaggag tctcaacatg tgtttctgac     4080

acaagatccg tggtttgtac tcaaagccca gaatccccaa gtgcctgctt ttgatgatgt     4140

ctacagaaaa tgctggctga gctgaacaca tttgcccaat tccaggtgtg cacagaaaac     4200

cgagaatatt caaaattcca aatttttttc ttaggagcaa gaagaaaatg tggccctaaa     4260

gggggttagt tgaggggtag ggggtagtga ggatcttgat ttggatctct ttttatttaa     4320

atgtgaattt caacttttga caatcaaaga aaagactttt gttgaaatag ctttactgtt     4380

tctcaagtgt tttggagaaa aaaatcaacc ctgcaatcac tttttggaat tgtcttgatt     4440

tttcggcagt tcaagctata tcgaatatag ttctgtgtag agaatgtcac tgtagttttg     4500

agtgtataca tgtgtgggtg ctgataattg tgtattttct ttgggggtgg aaaaggaaaa     4560

caattcaagc tgagaaaagt attctcaaag atgcattttt ataaatttta ttaaacaatt     4620

ttgttaaa                                                              4628


<210> 26
<211> 821
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Gly Leu Asp Phe Glu 
    370                 375                 380                 


Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro 
385                 390                 395                 400 


Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val 
                405                 410                 415     


Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val 
            420                 425                 430         


Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr 
        435                 440                 445             


Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile 
    450                 455                 460                 


Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala 
465                 470                 475                 480 


Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys 
                485                 490                 495     


Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro 
            500                 505                 510         


Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn 
        515                 520                 525             


Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg 
    530                 535                 540                 


Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro 
545                 550                 555                 560 


Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn 
                565                 570                 575     


Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys 
            580                 585                 590         


Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu 
        595                 600                 605             


Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val 
    610                 615                 620                 


Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val 
625                 630                 635                 640 


Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile 
                645                 650                 655     


Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg 
            660                 665                 670         


Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg 
        675                 680                 685             


Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
    690                 695                 700                 


Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu 
705                 710                 715                 720 


Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr 
                725                 730                 735     


Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
            740                 745                 750         


Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
        755                 760                 765             


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu 
    770                 775                 780                 


Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr 
785                 790                 795                 800 


Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly 
                805                 810                 815     


Gly Gly Glu Asp Asp 
            820     


<210> 27
<211> 4878
<212> DNA
<213> Homo sapiens

<400> 27
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaaggtttgt atggtacctg gcaagatgca gaaactggca tcctcacagc tgttcatacc     1500

cttgtcccct gggcttggat tttgaggcca agcagcagta cattctacac gtagcagtga     1560

cgaatgtggt accttttgag gtctctctca ccacctccac agccaccgtc accgtggatg     1620

tgctggatgt gaatgaagcc cccatctttg tgcctcctga aaagagagtg gaagtgtccg     1680

aggactttgg cgtgggccag gaaatcacat cctacactgc ccaggagcca gacacattta     1740

tggaacagaa aataacatat cggatttgga gagacactgc caactggctg gagattaatc     1800

cggacactgg tgccatttcc actcgggctg agctggacag ggaggatttt gagcacgtga     1860

agaacagcac gtacacagcc ctaatcatag ctacagacaa tggttctcca gttgctactg     1920

gaacagggac acttctgctg atcctgtctg atgtgaatga caacgccccc ataccagaac     1980

ctcgaactat attcttctgt gagaggaatc caaagcctca ggtcataaac atcattgatg     2040

cagaccttcc tcccaataca tctcccttca cagcagaact aacacacggg gcgagtgcca     2100

actggaccat tcagtacaac gacccaaccc aagaatctat cattttgaag ccaaagatgg     2160

ccttagaggt gggtgactac aaaatcaatc tcaagctcat ggataaccag aataaagacc     2220

aagtgaccac cttagaggtc agcgtgtgtg actgtgaagg ggccgctggc gtctgtagga     2280

aggcacagcc tgtcgaagca ggattgcaaa ttcctgccat tctggggatt cttggaggaa     2340

ttcttgcttt gctaattctg attctgctgc tcttgctgtt tcttcggagg agagcggtgg     2400

tcaaagagcc cttactgccc ccagaggatg acacccggga caacgtttat tactatgatg     2460

aagaaggagg cggagaagag gaccaggact ttgacttgag ccagctgcac aggggcctgg     2520

acgctcggcc tgaagtgact cgtaacgacg ttgcaccaac cctcatgagt gtcccccggt     2580

atcttccccg ccctgccaat cccgatgaaa ttggaaattt tattgatgaa aatctgaaag     2640

cggctgatac tgaccccaca gccccgcctt atgattctct gctcgtgttt gactatgaag     2700

gaagcggttc cgaagctgct agtctgagct ccctgaactc ctcagagtca gacaaagacc     2760

aggactatga ctacttgaac gaatggggca atcgcttcaa gaagctggct gacatgtacg     2820

gaggcggcga ggacgactag gggactcgag agaggcgggc cccagaccca tgtgctggga     2880

aatgcagaaa tcacgttgct ggtggttttt cagctccctt cccttgagat gagtttctgg     2940

ggaaaaaaaa gagactggtt agtgatgcag ttagtatagc tttatactct ctccacttta     3000

tagctctaat aagtttgtgt tagaaaagtt tcgacttatt tcttaaagct tttttttttt     3060

tcccatcact ctttacatgg tggtgatgtc caaaagatac ccaaatttta atattccaga     3120

agaacaactt tagcatcaga aggttcaccc agcaccttgc agattttctt aaggaatttt     3180

gtctcacttt taaaaagaag gggagaagtc agctactcta gttctgttgt tttgtgtata     3240

taatttttta aaaaaaattt gtgtgcttct gctcattact acactggtgt gtccctctgc     3300

cttttttttt tttttaagac agggtctcat tctatcggcc aggctggagt gcagtggtgc     3360

aatcacagct cactgcagcc ttgtcctccc aggctcaagc tatccttgca cctcagcctc     3420

ccaagtagct gggaccacag gcatgcacca ctacgcatga ctaatttttt aaatatttga     3480

gacggggtct ccctgtgtta cccaggctgg tctcaaactc ctgggctcaa gtgatcctcc     3540

catcttggcc tcccagagta ttgggattac agacatgagc cactgcacct gcccagctcc     3600

ccaactccct gccatttttt aagagacagt ttcgctccat cgcccaggcc tgggatgcag     3660

tgatgtgatc atagctcact gtaacctcaa actctggggc tcaagcagtt ctcccaccag     3720

cctccttttt atttttttgt acagatgggg tcttgctatg ttgcccaagc tggtcttaaa     3780

ctcctggcct caagcaatcc ttctgccttg gccccccaaa gtgctgggat tgtgggcatg     3840

agctgctgtg cccagcctcc atgttttaat atcaactctc actcctgaat tcagttgctt     3900

tgcccaagat aggagttctc tgatgcagaa attattgggc tcttttaggg taagaagttt     3960

gtgtctttgt ctggccacat cttgactagg tattgtctac tctgaagacc tttaatggct     4020

tccctctttc atctcctgag tatgtaactt gcaatgggca gctatccagt gacttgttct     4080

gagtaagtgt gttcattaat gtttatttag ctctgaagca agagtgatat actccaggac     4140

ttagaatagt gcctaaagtg ctgcagccaa agacagagcg gaactatgaa aagtgggctt     4200

ggagatggca ggagagcttg tcattgagcc tggcaattta gcaaactgat gctgaggatg     4260

attgaggtgg gtctacctca tctctgaaaa ttctggaagg aatggaggag tctcaacatg     4320

tgtttctgac acaagatccg tggtttgtac tcaaagccca gaatccccaa gtgcctgctt     4380

ttgatgatgt ctacagaaaa tgctggctga gctgaacaca tttgcccaat tccaggtgtg     4440

cacagaaaac cgagaatatt caaaattcca aatttttttc ttaggagcaa gaagaaaatg     4500

tggccctaaa gggggttagt tgaggggtag ggggtagtga ggatcttgat ttggatctct     4560

ttttatttaa atgtgaattt caacttttga caatcaaaga aaagactttt gttgaaatag     4620

ctttactgtt tctcaagtgt tttggagaaa aaaatcaacc ctgcaatcac tttttggaat     4680

tgtcttgatt tttcggcagt tcaagctata tcgaatatag ttctgtgtag agaatgtcac     4740

tgtagttttg agtgtataca tgtgtgggtg ctgataattg tgtattttct ttgggggtgg     4800

aaaaggaaaa caattcaagc tgagaaaagt attctcaaag atgcattttt ataaatttta     4860

ttaaacaatt ttgttaaa                                                   4878


<210> 28
<211> 366
<212> PRT
<213> Homo sapiens

<400> 28
Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp 
1               5                   10                  15      


Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu 
            20                  25                  30          


Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu 
        35                  40                  45              


Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr 
    50                  55                  60                  


Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu 
65                  70                  75                  80  


Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile 
                85                  90                  95      


Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala 
            100                 105                 110         


Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp 
        115                 120                 125             


Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val 
    130                 135                 140                 


Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp 
145                 150                 155                 160 


Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala 
                165                 170                 175     


Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro 
            180                 185                 190         


Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu Leu Ile Leu Ile 
        195                 200                 205             


Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val Val Lys Glu Pro 
    210                 215                 220                 


Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val Tyr Tyr Tyr Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp Leu Ser Gln Leu 
                245                 250                 255     


His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg Asn Asp Val Ala 
            260                 265                 270         


Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg Pro Ala Asn Pro 
        275                 280                 285             


Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Thr 
    290                 295                 300                 


Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu 
305                 310                 315                 320 


Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu Asn Ser Ser Glu 
                325                 330                 335     


Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Asn Arg 
            340                 345                 350         


Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
        355                 360                 365     


<210> 29
<211> 4665
<212> DNA
<213> Homo sapiens

<400> 29
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt     1500

ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga     1560

tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt     1620

tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca     1680

gaaaataacg ttctccagtt gctactggaa cagggacact tctgctgatc ctgtctgatg     1740

tgaatgacaa cgcccccata ccagaacctc gaactatatt cttctgtgag aggaatccaa     1800

agcctcaggt cataaacatc attgatgcag accttcctcc caatacatct cccttcacag     1860

cagaactaac acacggggcg agtgccaact ggaccattca gtacaacgac ccaacccaag     1920

aatctatcat tttgaagcca aagatggcct tagaggtggg tgactacaaa atcaatctca     1980

agctcatgga taaccagaat aaagaccaag tgaccacctt agaggtcagc gtgtgtgact     2040

gtgaaggggc cgctggcgtc tgtaggaagg cacagcctgt cgaagcagga ttgcaaattc     2100

ctgccattct ggggattctt ggaggaattc ttgctttgct aattctgatt ctgctgctct     2160

tgctgtttct tcggaggaga gcggtggtca aagagccctt actgccccca gaggatgaca     2220

cccgggacaa cgtttattac tatgatgaag aaggaggcgg agaagaggac caggactttg     2280

acttgagcca gctgcacagg ggcctggacg ctcggcctga agtgactcgt aacgacgttg     2340

caccaaccct catgagtgtc ccccggtatc ttccccgccc tgccaatccc gatgaaattg     2400

gaaattttat tgatgaaaat ctgaaagcgg ctgatactga ccccacagcc ccgccttatg     2460

attctctgct cgtgtttgac tatgaaggaa gcggttccga agctgctagt ctgagctccc     2520

tgaactcctc agagtcagac aaagaccagg actatgacta cttgaacgaa tggggcaatc     2580

gcttcaagaa gctggctgac atgtacggag gcggcgagga cgactagggg actcgagaga     2640

ggcgggcccc agacccatgt gctgggaaat gcagaaatca cgttgctggt ggtttttcag     2700

ctcccttccc ttgagatgag tttctgggga aaaaaaagag actggttagt gatgcagtta     2760

gtatagcttt atactctctc cactttatag ctctaataag tttgtgttag aaaagtttcg     2820

acttatttct taaagctttt ttttttttcc catcactctt tacatggtgg tgatgtccaa     2880

aagataccca aattttaata ttccagaaga acaactttag catcagaagg ttcacccagc     2940

accttgcaga ttttcttaag gaattttgtc tcacttttaa aaagaagggg agaagtcagc     3000

tactctagtt ctgttgtttt gtgtatataa ttttttaaaa aaaatttgtg tgcttctgct     3060

cattactaca ctggtgtgtc cctctgcctt tttttttttt ttaagacagg gtctcattct     3120

atcggccagg ctggagtgca gtggtgcaat cacagctcac tgcagccttg tcctcccagg     3180

ctcaagctat ccttgcacct cagcctccca agtagctggg accacaggca tgcaccacta     3240

cgcatgacta attttttaaa tatttgagac ggggtctccc tgtgttaccc aggctggtct     3300

caaactcctg ggctcaagtg atcctcccat cttggcctcc cagagtattg ggattacaga     3360

catgagccac tgcacctgcc cagctcccca actccctgcc attttttaag agacagtttc     3420

gctccatcgc ccaggcctgg gatgcagtga tgtgatcata gctcactgta acctcaaact     3480

ctggggctca agcagttctc ccaccagcct cctttttatt tttttgtaca gatggggtct     3540

tgctatgttg cccaagctgg tcttaaactc ctggcctcaa gcaatccttc tgccttggcc     3600

ccccaaagtg ctgggattgt gggcatgagc tgctgtgccc agcctccatg ttttaatatc     3660

aactctcact cctgaattca gttgctttgc ccaagatagg agttctctga tgcagaaatt     3720

attgggctct tttagggtaa gaagtttgtg tctttgtctg gccacatctt gactaggtat     3780

tgtctactct gaagaccttt aatggcttcc ctctttcatc tcctgagtat gtaacttgca     3840

atgggcagct atccagtgac ttgttctgag taagtgtgtt cattaatgtt tatttagctc     3900

tgaagcaaga gtgatatact ccaggactta gaatagtgcc taaagtgctg cagccaaaga     3960

cagagcggaa ctatgaaaag tgggcttgga gatggcagga gagcttgtca ttgagcctgg     4020

caatttagca aactgatgct gaggatgatt gaggtgggtc tacctcatct ctgaaaattc     4080

tggaaggaat ggaggagtct caacatgtgt ttctgacaca agatccgtgg tttgtactca     4140

aagcccagaa tccccaagtg cctgcttttg atgatgtcta cagaaaatgc tggctgagct     4200

gaacacattt gcccaattcc aggtgtgcac agaaaaccga gaatattcaa aattccaaat     4260

ttttttctta ggagcaagaa gaaaatgtgg ccctaaaggg ggttagttga ggggtagggg     4320

gtagtgagga tcttgatttg gatctctttt tatttaaatg tgaatttcaa cttttgacaa     4380

tcaaagaaaa gacttttgtt gaaatagctt tactgtttct caagtgtttt ggagaaaaaa     4440

atcaaccctg caatcacttt ttggaattgt cttgattttt cggcagttca agctatatcg     4500

aatatagttc tgtgtagaga atgtcactgt agttttgagt gtatacatgt gtgggtgctg     4560

ataattgtgt attttctttg ggggtggaaa aggaaaacaa ttcaagctga gaaaagtatt     4620

ctcaaagatg catttttata aattttatta aacaattttg ttaaa                     4665


<210> 30
<211> 227
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp 
1               5                   10                  15      


Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp 
            20                  25                  30          


Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala 
        35                  40                  45              


Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala 
    50                  55                  60                  


Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala 
65                  70                  75                  80  


Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn 
                85                  90                  95      


Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe 
            100                 105                 110         


Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr 
        115                 120                 125             


Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro 
    130                 135                 140                 


Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu 
145                 150                 155                 160 


Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu 
                165                 170                 175     


Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser 
            180                 185                 190         


Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn 
        195                 200                 205             


Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly 
    210                 215                 220                 


Glu Asp Asp 
225         


<210> 31
<211> 4811
<212> DNA
<213> Homo sapiens

<400> 31
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt     1500

ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga     1560

tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt     1620

tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca     1680

gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac     1740

tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag     1800

cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg     1860

gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac     1920

tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct     1980

tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac     2040

cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga     2100

ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac     2160

caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca     2220

gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc     2280

tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga     2340

gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaagg     2400

aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg     2460

gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc     2520

ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga     2580

tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg     2640

ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta     2700

tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg     2760

cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag     2820

aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa     2880

aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct     2940

aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc     3000

actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa     3060

ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac     3120

ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt     3180

ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt     3240

ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca     3300

gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta     3360

gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg     3420

tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg     3480

gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc     3540

cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg     3600

atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt     3660

tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg     3720

cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct     3780

gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa     3840

gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt     3900

tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct     3960

ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag     4020

tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat     4080

agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg     4140

gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg     4200

tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct     4260

gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga     4320

tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa     4380

aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct     4440

aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt     4500

taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact     4560

gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg     4620

atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt     4680

ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga     4740

aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca     4800

attttgttaa a                                                          4811


<210> 32
<211> 882
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210> 33
<211> 6192
<212> DNA
<213> Homo sapiens

<400> 33
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa agttacaaat tataatactg tggtagaaac      360

aaattcagat tcagatgatg aagacaaact gcatattgtg gaagaagaaa gtgttacaga      420

tgcagctgac tgtgaaggtg taccagagga tgacctgcca acagaccaga cagtgttacc      480

agggaggagc agtgaaagag aagggaatgc taagaactgc tgggaggatg acacaggaaa      540

ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat gaagcaggat gtacagtaaa      600

agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac catgatccta atgttgaaga      660

gtttctacaa caacaagaca ctgctgtcat ttttcctgag gcacctgaag aggaccagag      720

gcagggcaca ccagaagcca gtggtcatga tgaaaatgga acaccagatg cattttcaca      780

attactcacc tgtccatatt gtgatagagg ctataaacgc tttacctctc tgaaagaaca      840

cattaaatat cgtcatgaaa agaatgaaga taactttagt tgctccctgt gcagttacac      900

ctttgcatac agaacccaac ttgaacgtca catgacatca cataaatcag gaagagatca      960

aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc     1020

tttcaaatac aaacatcacc taaaagagca cttaagaatt cacagtggag agaagccata     1080

tgaatgccca aactgcaaga aacgcttttc ccattctggc tcctatagct cacacataag     1140

cagtaagaaa tgtatcagct tgatacctgt gaatgggcga ccaagaacag gactcaagac     1200

atctcagtgt tcttcaccgt ctctttcagc atcaccaggc agtcccacac gaccacagat     1260

acggcaaaag atagagaata aaccccttca agaacaactt tctgttaacc aaattaaaac     1320

tgaacctgtg gattatgaat tcaaacccat agtggttgct tcaggaatca actgttcaac     1380

ccctttacaa aatggggttt tcactggtgg tggcccatta caggcaacca gttctcctca     1440

gggcatggtg caagctgttg ttctgccaac agttggtttg gtgtctccca taagtatcaa     1500

tttaagtgat attcagaatg tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt     1560

gttggagaat aatcaagcca atcttgcatc caaagaacaa gaaacaatca atgcttcacc     1620

catacaacaa ggtggccatt ctgttatttc agccatcagt cttcctttgg ttgatcaaga     1680

tggaacaacc aaaattatca tcaactacag tcttgagcag cctagccaac ttcaagttgt     1740

tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt     1800

accagaagat cttactgtta agtctgagaa ggacaaaagc tttgaagggg gggtgaatga     1860

tagcacttgt cttctgtgtg atgattgtcc aggagatatt aatgcacttc cagaattaaa     1920

gcactatgac ctaaagcagc ctactcagcc tcctccactc cctgcagcag aagctgagaa     1980

gcctgagtcc tctgtttcat cagctactgg agatggcaat ttgtctccta gtcagccacc     2040

tttaaagaac ctcttgtctc tcctaaaagc atattatgct ttgaatgcac aaccaagtgc     2100

agaagagctc tcaaaaattg ctgattcagt aaacctacca ctggatgtag taaaaaagtg     2160

gtttgaaaag atgcaagctg gacagatttc agtgcagtct tctgaaccat cttctcctga     2220

accaggcaaa gtaaatatcc ctgccaagaa caatgatcag cctcaatctg caaatgcaaa     2280

tgaaccccag gacagcacag taaatctaca aagtcctttg aagatgacta actccccagt     2340

tttaccagtg ggatcaacca ccaatggttc cagaagtagt acaccatccc catcacctct     2400

aaacctttcc tcatccagaa atacacaggg ttacttgtac acagctgagg gtgcacaaga     2460

agagccacaa gtagaacctc ttgatctttc actaccaaag caacagggag aattattaga     2520

aaggtcaact atcactagtg tttaccagaa cagtgtttat tctgtccagg aagaaccctt     2580

gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt tgtgttacag actcagaacc     2640

agttgtaaat gtaatcccac caagtgccaa ccccataaat atcgctatac ctacagtcac     2700

tgcccagtta cccacaatcg tggccattgc tgaccagaac agtgttccat gcttaagagc     2760

gctagctgcc aataagcaaa cgattctgat tccccaggtg gcatacacct actcaactac     2820

ggtcagccct gcagtccaag aaccaccctt gaaagtgatc cagccaaatg gaaatcagga     2880

tgaaagacaa gatactagct cagaaggagt atcaaatgta gaggatcaga atgactctga     2940

ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt     3000

gtgtgacaag atattccaaa agagtagttc attattgaga cataaatatg aacacacagg     3060

taaaagacct catgagtgtg gaatctgtaa aaaggcattt aaacacaaac atcatttgat     3120

tgaacacatg cgattacatt ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg     3180

cttctcacac tctgggtctt attctcaaca catgaatcat cgctactcct actgtaagag     3240

agaagcggaa gaacgtgaca gcacagagca ggaagaggca gggcctgaaa tcctctcgaa     3300

tgagcacgtg ggtgccaggg cgtctccctc acagggcgac tcggacgaga gagagagttt     3360

gacaagggaa gaggatgaag acagtgaaaa agaggaagag gaggaggata aagagatgga     3420

agaattgcag gaagaaaaag aatgtgaaaa accacaaggg gatgaggaag aggaggagga     3480

ggaggaagaa gtggaagaag aagaggtaga agaggcagag aatgagggag aagaagcaaa     3540

aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa gcaagcagct taggacaaaa     3600

agtaggcgag agtagtgagc aagtgtctga agaaaagaca aatgaagcct aatcgttttt     3660

ctagaaggaa aataaattct aattgataat gaatttcgtt caatattatc cttgcttttc     3720

atggaaacac agtaacctgt atgctgtgat tcctgttcac tactgtgtaa agtaaaaact     3780

aaaaaaatac aaaatacaaa acacacacac acacacacac acacacacac acacacacac     3840

aaaataaatc cgggtgtgcc tgaacctcag acctagtaat ttttcatgca gttttcaaag     3900

ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct taatgactca gagagcaaca     3960

atacaagagg ttaaaggaag ctgattaatt agatatgcat ctggcattgt tttatcttat     4020

cagtattatc actcttatgt tggtttattc ttaagctgta caattgggag aaattttata     4080

attttttatt ggtaaacata tgctaaatcc gcttcagtat tttattatgt tttttaaaat     4140

gtgagaactt ctgcactaca aaattccctt cacagagaag tataatgtag ttccaacccg     4200

tgctaactac cttttataaa ttcagtctag aaggtagtaa tttctaatat ttagatgtct     4260

tagtagagcg tattatcatt taaagtgtat tgttagcctt aagaaagcag ctgatagaag     4320

aactgaagtt tcttactcac gtggtttaaa atggagttca aaagattgcc attgagttct     4380

gattgcaggg actaacaatg ttaatctgat aaggacagca aaatcatcag aatcagtgtt     4440

tgtgattgtg tttgaatatg tggtaacata tgaaggatat gacatgaagc tttgtatctc     4500

ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc     4560

taacccgcct tcatccaatg tgtggcctac aataactagc atttgttgat ttgtctcttg     4620

tatcaaaatt cccaaataaa acttaaaacc actgactctg tcagagaaac tgaaacactg     4680

ggacatttca tccttcaatt cctcggtatt gattttatgt tgattgattt tcagaatttc     4740

tctacagaaa cgaaagggaa attttctaat ctgctttatc catgtacttg catttcagac     4800

atggacatgc tattgttatt tggctcataa ctgtttccaa atgttagtta ttatggaccc     4860

aatttattaa caacattagc tgatttttac ctatcagtat tattttattt cttttagttt     4920

atagatctgt gcaacatttt tgtactgtat gtcttcaaac ctggcagtat taataccctt     4980

cttactgaca tatgtacttt tagttttaga aaacttttat atttatgtgt cttattttta     5040

tatttcttta tttattacac agtgtagtgt ataatactgt agtttgtatt aatacaataa     5100

tatattttag tatgaaaatt tggaaagttg ataagattta aagtagagat gcaattggtt     5160

ctcctgcatt gagatttgat ttaacagtgt tatgttaaca tttatacttg ccttggactg     5220

tagaacagaa cttaaatggg aatgtattag ttttacaact acaatcaagt cattttacct     5280

ttacccagtt tttaatataa aacttaaatt ttgaaattca ctgtgtgact aatagcatga     5340

tgctctgcag ttttattaag aaatcagcct aaccatacaa ctctcatttc cttagtaagc     5400

caaattagga ttaacttcta taaacagtgt tgggaacaat gtttaacatt ttgtgccaat     5460

ttgttcctgt attcatgtat gtaagttaca gatctgactc ttcattttta agttccttgt     5520

tacatcatgg tcattttcta gttttttacc agactcccat ctcacaataa aatgcatcaa     5580

caagcctgaa ctgctgtcat tcttttcatc attatcagta ttttctttgg aaaactgtga     5640

aatggggtac attgtcatcc tgcatttgat tcatcttgag ctgaatttgg gtaacactaa     5700

atgttttaga cattctccac taaattatgg attttcttgt ggctaaatgt ttctggagag     5760

gtcagagttg acaaaacctc ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc     5820

gcatttcatg cttcaggtca tttcagggaa gcctgggttt agatgccttt ctgactctca     5880

gctcctgcac ttctgtcatc atacctctga tactattatt tatattcctt ccccactagg     5940

aacaggaacc acatttgtca tagtcactct cacattcctc actgcctaac agggtgcctg     6000

gcataagttg ggacaacaga tatttgttga ataaaaatat aatttgcatg tttatggagc     6060

tcagctatgt tctcactttt tttgcttcta attccagaat atatgttaaa tgatctaata     6120

atttgattat tttcttataa gtcttattaa acactagtca taatagacac aataaattat     6180

gccttctttt tc                                                         6192


<210> 34
<211> 1108
<212> PRT
<213> Homo sapiens

<400> 34
Met Lys Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp Ser 
1               5                   10                  15      


Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr Asp 
            20                  25                  30          


Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp Gln 
        35                  40                  45              


Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys Asn 
    50                  55                  60                  


Cys Trp Glu Asp Asp Thr Gly Lys Glu Gly Gln Glu Ile Leu Gly Pro 
65                  70                  75                  80  


Glu Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp Glu Cys 
                85                  90                  95      


Glu Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu Glu 
            100                 105                 110         


Phe Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro Glu 
        115                 120                 125             


Glu Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu Asn 
    130                 135                 140                 


Gly Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys Asp 
145                 150                 155                 160 


Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr Arg 
                165                 170                 175     


His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr Thr 
            180                 185                 190         


Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser His Lys Ser 
        195                 200                 205             


Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys Phe 
    210                 215                 220                 


Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu Lys 
225                 230                 235                 240 


Glu His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn 
                245                 250                 255     


Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile Ser 
            260                 265                 270         


Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg Thr 
        275                 280                 285             


Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser Pro 
    290                 295                 300                 


Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys Pro 
305                 310                 315                 320 


Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val Asp 
                325                 330                 335     


Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser Thr 
            340                 345                 350         


Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala Thr 
        355                 360                 365             


Ser Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro Thr Val Gly 
    370                 375                 380                 


Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val Leu 
385                 390                 395                 400 


Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn Asn 
                405                 410                 415     


Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser Pro 
            420                 425                 430         


Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro Leu 
        435                 440                 445             


Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu Glu 
    450                 455                 460                 


Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu Asn 
465                 470                 475                 480 


Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp Leu 
                485                 490                 495     


Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn Asp 
            500                 505                 510         


Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala Leu 
        515                 520                 525             


Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro Pro 
    530                 535                 540                 


Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser Ala 
545                 550                 555                 560 


Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn Leu 
                565                 570                 575     


Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser Ala 
            580                 585                 590         


Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp Val 
        595                 600                 605             


Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val Gln 
    610                 615                 620                 


Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro Ala 
625                 630                 635                 640 


Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln Asp 
                645                 650                 655     


Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro Val 
            660                 665                 670         


Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro Ser 
        675                 680                 685             


Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr Leu 
    690                 695                 700                 


Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu Asp 
705                 710                 715                 720 


Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr Ile 
                725                 730                 735     


Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro Leu 
            740                 745                 750         


Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val Thr 
        755                 760                 765             


Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro Ile 
    770                 775                 780                 


Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val Ala 
785                 790                 795                 800 


Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala Asn 
                805                 810                 815     


Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr Thr 
            820                 825                 830         


Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro Asn 
        835                 840                 845             


Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser Asn 
    850                 855                 860                 


Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys Met 
865                 870                 875                 880 


Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Ile 
                885                 890                 895     


Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly 
            900                 905                 910         


Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His Lys 
        915                 920                 925             


His His Leu Ile Glu His Met Arg Leu His Ser Gly Glu Lys Pro Tyr 
    930                 935                 940                 


Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser 
945                 950                 955                 960 


Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu 
                965                 970                 975     


Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly Pro Glu Ile Leu Ser Asn 
            980                 985                 990         


Glu His Val Gly Ala Arg Ala Ser  Pro Ser Gln Gly Asp  Ser Asp Glu 
        995                 1000                 1005             


Arg Glu  Ser Leu Thr Arg Glu  Glu Asp Glu Asp Ser  Glu Lys Glu 
    1010                 1015                 1020             


Glu Glu  Glu Glu Asp Lys Glu  Met Glu Glu Leu Gln  Glu Glu Lys 
    1025                 1030                 1035             


Glu Cys  Glu Lys Pro Gln Gly  Asp Glu Glu Glu Glu  Glu Glu Glu 
    1040                 1045                 1050             


Glu Glu  Val Glu Glu Glu Glu  Val Glu Glu Ala Glu  Asn Glu Gly 
    1055                 1060                 1065             


Glu Glu  Ala Lys Thr Glu Gly  Leu Met Lys Asp Asp  Arg Ala Glu 
    1070                 1075                 1080             


Ser Gln  Ala Ser Ser Leu Gly  Gln Lys Val Gly Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gln Val  Ser Glu Glu Lys Thr  Asn Glu Ala 
    1100                 1105             


<210> 35
<211> 5874
<212> DNA
<213> Homo sapiens

<400> 35
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgtta caaattataa tactgtggta gaaacaaatt cagattcaga      120

tgatgaagac aaactgcata ttgtggaaga agaaagtgtt acagatgcag ctgactgtga      180

aggtgtacca gaggatgacc tgccaacaga ccagacagtg ttaccaggga ggagcagtga      240

aagagaaggg aatgctaaga actgctggga ggatgacata aaagatgatg aatgcgagtc      300

agatgcagaa aatgagcaaa accatgatcc taatgttgaa gagtttctac aacaacaaga      360

cactgctgtc atttttcctg aggcacctga agaggaccag aggcagggca caccagaagc      420

cagtggtcat gatgaaaatg gaacaccaga tgcattttca caattactca cctgtccata      480

ttgtgataga ggctataaac gctttacctc tctgaaagaa cacattaaat atcgtcatga      540

aaagaatgaa gataacttta gttgctccct gtgcagttac acctttgcat acagaaccca      600

acttgaacgt cacatgacat cacataaatc aggaagagat caaagacatg tgacgcagtc      660

tgggtgtaat cgtaaattca aatgcactga gtgtggaaaa gctttcaaat acaaacatca      720

cctaaaagag cacttaagaa ttcacagtgg agagaagcca tatgaatgcc caaactgcaa      780

gaaacgcttt tcccattctg gctcctatag ctcacacata agcagtaaga aatgtatcag      840

cttgatacct gtgaatgggc gaccaagaac aggactcaag acatctcagt gttcttcacc      900

gtctctttca gcatcaccag gcagtcccac acgaccacag atacggcaaa agatagagaa      960

taaacccctt caagaacaac tttctgttaa ccaaattaaa actgaacctg tggattatga     1020

attcaaaccc atagtggttg cttcaggaat caactgttca acccctttac aaaatggggt     1080

tttcactggt ggtggcccat tacaggcaac cagttctcct cagggcatgg tgcaagctgt     1140

tgttctgcca acagttggtt tggtgtctcc cataagtatc aatttaagtg atattcagaa     1200

tgtacttaaa gtggcggtag atggtaatgt aataaggcaa gtgttggaga ataatcaagc     1260

caatcttgca tccaaagaac aagaaacaat caatgcttca cccatacaac aaggtggcca     1320

ttctgttatt tcagccatca gtcttccttt ggttgatcaa gatggaacaa ccaaaattat     1380

catcaactac agtcttgagc agcctagcca acttcaagtt gttcctcaaa atttaaaaaa     1440

agaaaatcca gtcgctacaa acagttgtaa aagtgaaaag ttaccagaag atcttactgt     1500

taagtctgag aaggacaaaa gctttgaagg gggggtgaat gatagcactt gtcttctgtg     1560

tgatgattgt ccaggagata ttaatgcact tccagaatta aagcactatg acctaaagca     1620

gcctactcag cctcctccac tccctgcagc agaagctgag aagcctgagt cctctgtttc     1680

atcagctact ggagatggca atttgtctcc tagtcagcca cctttaaaga acctcttgtc     1740

tctcctaaaa gcatattatg ctttgaatgc acaaccaagt gcagaagagc tctcaaaaat     1800

tgctgattca gtaaacctac cactggatgt agtaaaaaag tggtttgaaa agatgcaagc     1860

tggacagatt tcagtgcagt cttctgaacc atcttctcct gaaccaggca aagtaaatat     1920

ccctgccaag aacaatgatc agcctcaatc tgcaaatgca aatgaacccc aggacagcac     1980

agtaaatcta caaagtcctt tgaagatgac taactcccca gttttaccag tgggatcaac     2040

caccaatggt tccagaagta gtacaccatc cccatcacct ctaaaccttt cctcatccag     2100

aaatacacag ggttacttgt acacagctga gggtgcacaa gaagagccac aagtagaacc     2160

tcttgatctt tcactaccaa agcaacaggg agaattatta gaaaggtcaa ctatcactag     2220

tgtttaccag aacagtgttt attctgtcca ggaagaaccc ttgaacttgt cttgcgcaaa     2280

aaaggagcca caaaaggaca gttgtgttac agactcagaa ccagttgtaa atgtaatccc     2340

accaagtgcc aaccccataa atatcgctat acctacagtc actgcccagt tacccacaat     2400

cgtggccatt gctgaccaga acagtgttcc atgcttaaga gcgctagctg ccaataagca     2460

aacgattctg attccccagg tggcatacac ctactcaact acggtcagcc ctgcagtcca     2520

agaaccaccc ttgaaagtga tccagccaaa tggaaatcag gatgaaagac aagatactag     2580

ctcagaagga gtatcaaatg tagaggatca gaatgactct gattctacac cgcccaaaaa     2640

gaaaatgcgg aagacagaaa atggaatgta tgcttgtgat ttgtgtgaca agatattcca     2700

aaagagtagt tcattattga gacataaata tgaacacaca ggtaaaagac ctcatgagtg     2760

tggaatctgt aaaaaggcat ttaaacacaa acatcatttg attgaacaca tgcgattaca     2820

ttctggagaa aagccctatc aatgtgacaa atgtggaaag cgcttctcac actctgggtc     2880

ttattctcaa cacatgaatc atcgctactc ctactgtaag agagaagcgg aagaacgtga     2940

cagcacagag caggaagagg cagggcctga aatcctctcg aatgagcacg tgggtgccag     3000

ggcgtctccc tcacagggcg actcggacga gagagagagt ttgacaaggg aagaggatga     3060

agacagtgaa aaagaggaag aggaggagga taaagagatg gaagaattgc aggaagaaaa     3120

agaatgtgaa aaaccacaag gggatgagga agaggaggag gaggaggaag aagtggaaga     3180

agaagaggta gaagaggcag agaatgaggg agaagaagca aaaactgaag gtctgatgaa     3240

ggatgacagg gctgaaagtc aagcaagcag cttaggacaa aaagtaggcg agagtagtga     3300

gcaagtgtct gaagaaaaga caaatgaagc ctaatcgttt ttctagaagg aaaataaatt     3360

ctaattgata atgaatttcg ttcaatatta tccttgcttt tcatggaaac acagtaacct     3420

gtatgctgtg attcctgttc actactgtgt aaagtaaaaa ctaaaaaaat acaaaataca     3480

aaacacacac acacacacac acacacacac acacacacac acaaaataaa tccgggtgtg     3540

cctgaacctc agacctagta atttttcatg cagttttcaa agttaggaac aagtttgtaa     3600

catgcagcag attagaaaac cttaatgact cagagagcaa caatacaaga ggttaaagga     3660

agctgattaa ttagatatgc atctggcatt gttttatctt atcagtatta tcactcttat     3720

gttggtttat tcttaagctg tacaattggg agaaatttta taatttttta ttggtaaaca     3780

tatgctaaat ccgcttcagt attttattat gttttttaaa atgtgagaac ttctgcacta     3840

caaaattccc ttcacagaga agtataatgt agttccaacc cgtgctaact accttttata     3900

aattcagtct agaaggtagt aatttctaat atttagatgt cttagtagag cgtattatca     3960

tttaaagtgt attgttagcc ttaagaaagc agctgataga agaactgaag tttcttactc     4020

acgtggttta aaatggagtt caaaagattg ccattgagtt ctgattgcag ggactaacaa     4080

tgttaatctg ataaggacag caaaatcatc agaatcagtg tttgtgattg tgtttgaata     4140

tgtggtaaca tatgaaggat atgacatgaa gctttgtatc tcctttggcc ttaagcaaga     4200

cctgtgtgct gtaagtgcca tttctcagta ttttcaaggc tctaacccgc cttcatccaa     4260

tgtgtggcct acaataacta gcatttgttg atttgtctct tgtatcaaaa ttcccaaata     4320

aaacttaaaa ccactgactc tgtcagagaa actgaaacac tgggacattt catccttcaa     4380

ttcctcggta ttgattttat gttgattgat tttcagaatt tctctacaga aacgaaaggg     4440

aaattttcta atctgcttta tccatgtact tgcatttcag acatggacat gctattgtta     4500

tttggctcat aactgtttcc aaatgttagt tattatggac ccaatttatt aacaacatta     4560

gctgattttt acctatcagt attattttat ttcttttagt ttatagatct gtgcaacatt     4620

tttgtactgt atgtcttcaa acctggcagt attaataccc ttcttactga catatgtact     4680

tttagtttta gaaaactttt atatttatgt gtcttatttt tatatttctt tatttattac     4740

acagtgtagt gtataatact gtagtttgta ttaatacaat aatatatttt agtatgaaaa     4800

tttggaaagt tgataagatt taaagtagag atgcaattgg ttctcctgca ttgagatttg     4860

atttaacagt gttatgttaa catttatact tgccttggac tgtagaacag aacttaaatg     4920

ggaatgtatt agttttacaa ctacaatcaa gtcattttac ctttacccag tttttaatat     4980

aaaacttaaa ttttgaaatt cactgtgtga ctaatagcat gatgctctgc agttttatta     5040

agaaatcagc ctaaccatac aactctcatt tccttagtaa gccaaattag gattaacttc     5100

tataaacagt gttgggaaca atgtttaaca ttttgtgcca atttgttcct gtattcatgt     5160

atgtaagtta cagatctgac tcttcatttt taagttcctt gttacatcat ggtcattttc     5220

tagtttttta ccagactccc atctcacaat aaaatgcatc aacaagcctg aactgctgtc     5280

attcttttca tcattatcag tattttcttt ggaaaactgt gaaatggggt acattgtcat     5340

cctgcatttg attcatcttg agctgaattt gggtaacact aaatgtttta gacattctcc     5400

actaaattat ggattttctt gtggctaaat gtttctggag aggtcagagt tgacaaaacc     5460

tcttcacagg ttgctccttc ttcctgaaat ccttaatcct ccgcatttca tgcttcaggt     5520

catttcaggg aagcctgggt ttagatgcct ttctgactct cagctcctgc acttctgtca     5580

tcatacctct gatactatta tttatattcc ttccccacta ggaacaggaa ccacatttgt     5640

catagtcact ctcacattcc tcactgccta acagggtgcc tggcataagt tgggacaaca     5700

gatatttgtt gaataaaaat ataatttgca tgtttatgga gctcagctat gttctcactt     5760

tttttgcttc taattccaga atatatgtta aatgatctaa taatttgatt attttcttat     5820

aagtcttatt aaacactagt cataatagac acaataaatt atgccttctt tttc           5874


<210> 36
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys Gln Ala Asn Pro Arg 
1               5                   10                  15      


Arg Asn Asn Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp 
            20                  25                  30          


Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr 
        35                  40                  45              


Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp 
    50                  55                  60                  


Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys 
65                  70                  75                  80  


Asn Cys Trp Glu Asp Asp Ile Lys Asp Asp Glu Cys Glu Ser Asp Ala 
                85                  90                  95      


Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu Glu Phe Leu Gln Gln 
            100                 105                 110         


Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro Glu Glu Asp Gln Arg 
        115                 120                 125             


Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu Asn Gly Thr Pro Asp 
    130                 135                 140                 


Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys Asp Arg Gly Tyr Lys 
145                 150                 155                 160 


Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr Arg His Glu Lys Asn 
                165                 170                 175     


Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr Thr Phe Ala Tyr Arg 
            180                 185                 190         


Thr Gln Leu Glu Arg His Met Thr Ser His Lys Ser Gly Arg Asp Gln 
        195                 200                 205             


Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu 
    210                 215                 220                 


Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu Lys Glu His Leu Arg 
225                 230                 235                 240 


Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg 
                245                 250                 255     


Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile Ser Ser Lys Lys Cys 
            260                 265                 270         


Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr 
        275                 280                 285             


Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr 
    290                 295                 300                 


Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln 
305                 310                 315                 320 


Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys 
                325                 330                 335     


Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn 
            340                 345                 350         


Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln 
        355                 360                 365             


Gly Met Val Gln Ala Val Val Leu Pro Thr Val Gly Leu Val Ser Pro 
    370                 375                 380                 


Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val Leu Lys Val Ala Val 
385                 390                 395                 400 


Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn Asn Gln Ala Asn Leu 
                405                 410                 415     


Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly 
            420                 425                 430         


Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro Leu Val Asp Gln Asp 
        435                 440                 445             


Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln 
    450                 455                 460                 


Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu Asn Pro Val Ala Thr 
465                 470                 475                 480 


Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp Leu Thr Val Lys Ser 
                485                 490                 495     


Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn Asp Ser Thr Cys Leu 
            500                 505                 510         


Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys 
        515                 520                 525             


His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala 
    530                 535                 540                 


Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser Ala Thr Gly Asp Gly 
545                 550                 555                 560 


Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu 
                565                 570                 575     


Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser 
            580                 585                 590         


Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp Val Val Lys Lys Trp 
        595                 600                 605             


Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val Gln Ser Ser Glu Pro 
    610                 615                 620                 


Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro Ala Lys Asn Asn Asp 
625                 630                 635                 640 


Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln Asp Ser Thr Val Asn 
                645                 650                 655     


Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro Val Leu Pro Val Gly 
            660                 665                 670         


Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu 
        675                 680                 685             


Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu 
    690                 695                 700                 


Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu Asp Leu Ser Leu Pro 
705                 710                 715                 720 


Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr 
                725                 730                 735     


Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro Leu Asn Leu Ser Cys 
            740                 745                 750         


Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val Thr Asp Ser Glu Pro 
        755                 760                 765             


Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile 
    770                 775                 780                 


Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val Ala Ile Ala Asp Gln 
785                 790                 795                 800 


Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile 
                805                 810                 815     


Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala 
            820                 825                 830         


Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro Asn Gly Asn Gln Asp 
        835                 840                 845             


Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser Asn Val Glu Asp Gln 
    850                 855                 860                 


Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys Met Arg Lys Thr Glu 
865                 870                 875                 880 


Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser 
                885                 890                 895     


Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly Lys Arg Pro His 
            900                 905                 910         


Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His Lys His His Leu Ile 
        915                 920                 925             


Glu His Met Arg Leu His Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys 
    930                 935                 940                 


Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Gln His Met Asn 
945                 950                 955                 960 


His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr 
                965                 970                 975     


Glu Gln Glu Glu Ala Gly Pro Glu Ile Leu Ser Asn Glu His Val Gly 
            980                 985                 990         


Ala Arg Ala Ser Pro Ser Gln Gly  Asp Ser Asp Glu Arg  Glu Ser Leu 
        995                 1000                 1005             


Thr Arg  Glu Glu Asp Glu Asp  Ser Glu Lys Glu Glu  Glu Glu Glu 
    1010                 1015                 1020             


Asp Lys  Glu Met Glu Glu Leu  Gln Glu Glu Lys Glu  Cys Glu Lys 
    1025                 1030                 1035             


Pro Gln  Gly Asp Glu Glu Glu  Glu Glu Glu Glu Glu  Glu Val Glu 
    1040                 1045                 1050             


Glu Glu  Glu Val Glu Glu Ala  Glu Asn Glu Gly Glu  Glu Ala Lys 
    1055                 1060                 1065             


Thr Glu  Gly Leu Met Lys Asp  Asp Arg Ala Glu Ser  Gln Ala Ser 
    1070                 1075                 1080             


Ser Leu  Gly Gln Lys Val Gly  Glu Ser Ser Glu Gln  Val Ser Glu 
    1085                 1090                 1095             


Glu Lys  Thr Asn Glu Ala 
    1100                 


<210> 37
<211> 6189
<212> DNA
<213> Homo sapiens

<400> 37
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa agttacaaat tataatactg tggtagaaac      360

aaattcagat tcagatgatg aagacaaact gcatattgtg gaagaagaaa gtgttacaga      420

tgcagctgac tgtgaaggtg taccagagga tgacctgcca acagaccaga cagtgttacc      480

agggaggagc agtgaaagag aagggaatgc taagaactgc tgggaggatg acagaaagga      540

agggcaagaa atcctggggc ctgaagctca ggcagatgaa gcaggatgta cagtaaaaga      600

tgatgaatgc gagtcagatg cagaaaatga gcaaaaccat gatcctaatg ttgaagagtt      660

tctacaacaa caagacactg ctgtcatttt tcctgaggca cctgaagagg accagaggca      720

gggcacacca gaagccagtg gtcatgatga aaatggaaca ccagatgcat tttcacaatt      780

actcacctgt ccatattgtg atagaggcta taaacgcttt acctctctga aagaacacat      840

taaatatcgt catgaaaaga atgaagataa ctttagttgc tccctgtgca gttacacctt      900

tgcatacaga acccaacttg aacgtcacat gacatcacat aaatcaggaa gagatcaaag      960

acatgtgacg cagtctgggt gtaatcgtaa attcaaatgc actgagtgtg gaaaagcttt     1020

caaatacaaa catcacctaa aagagcactt aagaattcac agtggagaga agccatatga     1080

atgcccaaac tgcaagaaac gcttttccca ttctggctcc tatagctcac acataagcag     1140

taagaaatgt atcagcttga tacctgtgaa tgggcgacca agaacaggac tcaagacatc     1200

tcagtgttct tcaccgtctc tttcagcatc accaggcagt cccacacgac cacagatacg     1260

gcaaaagata gagaataaac cccttcaaga acaactttct gttaaccaaa ttaaaactga     1320

acctgtggat tatgaattca aacccatagt ggttgcttca ggaatcaact gttcaacccc     1380

tttacaaaat ggggttttca ctggtggtgg cccattacag gcaaccagtt ctcctcaggg     1440

catggtgcaa gctgttgttc tgccaacagt tggtttggtg tctcccataa gtatcaattt     1500

aagtgatatt cagaatgtac ttaaagtggc ggtagatggt aatgtaataa ggcaagtgtt     1560

ggagaataat caagccaatc ttgcatccaa agaacaagaa acaatcaatg cttcacccat     1620

acaacaaggt ggccattctg ttatttcagc catcagtctt cctttggttg atcaagatgg     1680

aacaaccaaa attatcatca actacagtct tgagcagcct agccaacttc aagttgttcc     1740

tcaaaattta aaaaaagaaa atccagtcgc tacaaacagt tgtaaaagtg aaaagttacc     1800

agaagatctt actgttaagt ctgagaagga caaaagcttt gaaggggggg tgaatgatag     1860

cacttgtctt ctgtgtgatg attgtccagg agatattaat gcacttccag aattaaagca     1920

ctatgaccta aagcagccta ctcagcctcc tccactccct gcagcagaag ctgagaagcc     1980

tgagtcctct gtttcatcag ctactggaga tggcaatttg tctcctagtc agccaccttt     2040

aaagaacctc ttgtctctcc taaaagcata ttatgctttg aatgcacaac caagtgcaga     2100

agagctctca aaaattgctg attcagtaaa cctaccactg gatgtagtaa aaaagtggtt     2160

tgaaaagatg caagctggac agatttcagt gcagtcttct gaaccatctt ctcctgaacc     2220

aggcaaagta aatatccctg ccaagaacaa tgatcagcct caatctgcaa atgcaaatga     2280

accccaggac agcacagtaa atctacaaag tcctttgaag atgactaact ccccagtttt     2340

accagtggga tcaaccacca atggttccag aagtagtaca ccatccccat cacctctaaa     2400

cctttcctca tccagaaata cacagggtta cttgtacaca gctgagggtg cacaagaaga     2460

gccacaagta gaacctcttg atctttcact accaaagcaa cagggagaat tattagaaag     2520

gtcaactatc actagtgttt accagaacag tgtttattct gtccaggaag aacccttgaa     2580

cttgtcttgc gcaaaaaagg agccacaaaa ggacagttgt gttacagact cagaaccagt     2640

tgtaaatgta atcccaccaa gtgccaaccc cataaatatc gctataccta cagtcactgc     2700

ccagttaccc acaatcgtgg ccattgctga ccagaacagt gttccatgct taagagcgct     2760

agctgccaat aagcaaacga ttctgattcc ccaggtggca tacacctact caactacggt     2820

cagccctgca gtccaagaac cacccttgaa agtgatccag ccaaatggaa atcaggatga     2880

aagacaagat actagctcag aaggagtatc aaatgtagag gatcagaatg actctgattc     2940

tacaccgccc aaaaagaaaa tgcggaagac agaaaatgga atgtatgctt gtgatttgtg     3000

tgacaagata ttccaaaaga gtagttcatt attgagacat aaatatgaac acacaggtaa     3060

aagacctcat gagtgtggaa tctgtaaaaa ggcatttaaa cacaaacatc atttgattga     3120

acacatgcga ttacattctg gagaaaagcc ctatcaatgt gacaaatgtg gaaagcgctt     3180

ctcacactct gggtcttatt ctcaacacat gaatcatcgc tactcctact gtaagagaga     3240

agcggaagaa cgtgacagca cagagcagga agaggcaggg cctgaaatcc tctcgaatga     3300

gcacgtgggt gccagggcgt ctccctcaca gggcgactcg gacgagagag agagtttgac     3360

aagggaagag gatgaagaca gtgaaaaaga ggaagaggag gaggataaag agatggaaga     3420

attgcaggaa gaaaaagaat gtgaaaaacc acaaggggat gaggaagagg aggaggagga     3480

ggaagaagtg gaagaagaag aggtagaaga ggcagagaat gagggagaag aagcaaaaac     3540

tgaaggtctg atgaaggatg acagggctga aagtcaagca agcagcttag gacaaaaagt     3600

aggcgagagt agtgagcaag tgtctgaaga aaagacaaat gaagcctaat cgtttttcta     3660

gaaggaaaat aaattctaat tgataatgaa tttcgttcaa tattatcctt gcttttcatg     3720

gaaacacagt aacctgtatg ctgtgattcc tgttcactac tgtgtaaagt aaaaactaaa     3780

aaaatacaaa atacaaaaca cacacacaca cacacacaca cacacacaca cacacacaaa     3840

ataaatccgg gtgtgcctga acctcagacc tagtaatttt tcatgcagtt ttcaaagtta     3900

ggaacaagtt tgtaacatgc agcagattag aaaaccttaa tgactcagag agcaacaata     3960

caagaggtta aaggaagctg attaattaga tatgcatctg gcattgtttt atcttatcag     4020

tattatcact cttatgttgg tttattctta agctgtacaa ttgggagaaa ttttataatt     4080

ttttattggt aaacatatgc taaatccgct tcagtatttt attatgtttt ttaaaatgtg     4140

agaacttctg cactacaaaa ttcccttcac agagaagtat aatgtagttc caacccgtgc     4200

taactacctt ttataaattc agtctagaag gtagtaattt ctaatattta gatgtcttag     4260

tagagcgtat tatcatttaa agtgtattgt tagccttaag aaagcagctg atagaagaac     4320

tgaagtttct tactcacgtg gtttaaaatg gagttcaaaa gattgccatt gagttctgat     4380

tgcagggact aacaatgtta atctgataag gacagcaaaa tcatcagaat cagtgtttgt     4440

gattgtgttt gaatatgtgg taacatatga aggatatgac atgaagcttt gtatctcctt     4500

tggccttaag caagacctgt gtgctgtaag tgccatttct cagtattttc aaggctctaa     4560

cccgccttca tccaatgtgt ggcctacaat aactagcatt tgttgatttg tctcttgtat     4620

caaaattccc aaataaaact taaaaccact gactctgtca gagaaactga aacactggga     4680

catttcatcc ttcaattcct cggtattgat tttatgttga ttgattttca gaatttctct     4740

acagaaacga aagggaaatt ttctaatctg ctttatccat gtacttgcat ttcagacatg     4800

gacatgctat tgttatttgg ctcataactg tttccaaatg ttagttatta tggacccaat     4860

ttattaacaa cattagctga tttttaccta tcagtattat tttatttctt ttagtttata     4920

gatctgtgca acatttttgt actgtatgtc ttcaaacctg gcagtattaa tacccttctt     4980

actgacatat gtacttttag ttttagaaaa cttttatatt tatgtgtctt atttttatat     5040

ttctttattt attacacagt gtagtgtata atactgtagt ttgtattaat acaataatat     5100

attttagtat gaaaatttgg aaagttgata agatttaaag tagagatgca attggttctc     5160

ctgcattgag atttgattta acagtgttat gttaacattt atacttgcct tggactgtag     5220

aacagaactt aaatgggaat gtattagttt tacaactaca atcaagtcat tttaccttta     5280

cccagttttt aatataaaac ttaaattttg aaattcactg tgtgactaat agcatgatgc     5340

tctgcagttt tattaagaaa tcagcctaac catacaactc tcatttcctt agtaagccaa     5400

attaggatta acttctataa acagtgttgg gaacaatgtt taacattttg tgccaatttg     5460

ttcctgtatt catgtatgta agttacagat ctgactcttc atttttaagt tccttgttac     5520

atcatggtca ttttctagtt ttttaccaga ctcccatctc acaataaaat gcatcaacaa     5580

gcctgaactg ctgtcattct tttcatcatt atcagtattt tctttggaaa actgtgaaat     5640

ggggtacatt gtcatcctgc atttgattca tcttgagctg aatttgggta acactaaatg     5700

ttttagacat tctccactaa attatggatt ttcttgtggc taaatgtttc tggagaggtc     5760

agagttgaca aaacctcttc acaggttgct ccttcttcct gaaatcctta atcctccgca     5820

tttcatgctt caggtcattt cagggaagcc tgggtttaga tgcctttctg actctcagct     5880

cctgcacttc tgtcatcata cctctgatac tattatttat attccttccc cactaggaac     5940

aggaaccaca tttgtcatag tcactctcac attcctcact gcctaacagg gtgcctggca     6000

taagttggga caacagatat ttgttgaata aaaatataat ttgcatgttt atggagctca     6060

gctatgttct cacttttttt gcttctaatt ccagaatata tgttaaatga tctaataatt     6120

tgattatttt cttataagtc ttattaaaca ctagtcataa tagacacaat aaattatgcc     6180

ttctttttc                                                             6189


<210> 38
<211> 1107
<212> PRT
<213> Homo sapiens

<400> 38
Met Lys Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp Ser 
1               5                   10                  15      


Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr Asp 
            20                  25                  30          


Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp Gln 
        35                  40                  45              


Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys Asn 
    50                  55                  60                  


Cys Trp Glu Asp Asp Arg Lys Glu Gly Gln Glu Ile Leu Gly Pro Glu 
65                  70                  75                  80  


Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp Glu Cys Glu 
                85                  90                  95      


Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu Glu Phe 
            100                 105                 110         


Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro Glu Glu 
        115                 120                 125             


Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu Asn Gly 
    130                 135                 140                 


Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys Asp Arg 
145                 150                 155                 160 


Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr Arg His 
                165                 170                 175     


Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr Thr Phe 
            180                 185                 190         


Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser His Lys Ser Gly 
        195                 200                 205             


Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys Phe Lys 
    210                 215                 220                 


Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu Lys Glu 
225                 230                 235                 240 


His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn Cys 
                245                 250                 255     


Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile Ser Ser 
            260                 265                 270         


Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg Thr Gly 
        275                 280                 285             


Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser Pro Gly 
    290                 295                 300                 


Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys Pro Leu 
305                 310                 315                 320 


Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val Asp Tyr 
                325                 330                 335     


Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser Thr Pro 
            340                 345                 350         


Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala Thr Ser 
        355                 360                 365             


Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro Thr Val Gly Leu 
    370                 375                 380                 


Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val Leu Lys 
385                 390                 395                 400 


Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn Asn Gln 
                405                 410                 415     


Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser Pro Ile 
            420                 425                 430         


Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro Leu Val 
        435                 440                 445             


Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu Glu Gln 
    450                 455                 460                 


Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu Asn Pro 
465                 470                 475                 480 


Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp Leu Thr 
                485                 490                 495     


Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn Asp Ser 
            500                 505                 510         


Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala Leu Pro 
        515                 520                 525             


Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro Pro Leu 
    530                 535                 540                 


Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser Ala Thr 
545                 550                 555                 560 


Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn Leu Leu 
                565                 570                 575     


Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser Ala Glu 
            580                 585                 590         


Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp Val Val 
        595                 600                 605             


Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val Gln Ser 
    610                 615                 620                 


Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro Ala Lys 
625                 630                 635                 640 


Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln Asp Ser 
                645                 650                 655     


Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro Val Leu 
            660                 665                 670         


Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro Ser Pro 
        675                 680                 685             


Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr Leu Tyr 
    690                 695                 700                 


Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu Asp Leu 
705                 710                 715                 720 


Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr Ile Thr 
                725                 730                 735     


Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro Leu Asn 
            740                 745                 750         


Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val Thr Asp 
        755                 760                 765             


Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro Ile Asn 
    770                 775                 780                 


Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val Ala Ile 
785                 790                 795                 800 


Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala Asn Lys 
                805                 810                 815     


Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr Thr Val 
            820                 825                 830         


Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro Asn Gly 
        835                 840                 845             


Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser Asn Val 
    850                 855                 860                 


Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys Met Arg 
865                 870                 875                 880 


Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Ile Phe 
                885                 890                 895     


Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly Lys 
            900                 905                 910         


Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His Lys His 
        915                 920                 925             


His Leu Ile Glu His Met Arg Leu His Ser Gly Glu Lys Pro Tyr Gln 
    930                 935                 940                 


Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Gln 
945                 950                 955                 960 


His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu Arg 
                965                 970                 975     


Asp Ser Thr Glu Gln Glu Glu Ala Gly Pro Glu Ile Leu Ser Asn Glu 
            980                 985                 990         


His Val Gly Ala Arg Ala Ser Pro  Ser Gln Gly Asp Ser  Asp Glu Arg 
        995                 1000                 1005             


Glu Ser  Leu Thr Arg Glu Glu  Asp Glu Asp Ser Glu  Lys Glu Glu 
    1010                 1015                 1020             


Glu Glu  Glu Asp Lys Glu Met  Glu Glu Leu Gln Glu  Glu Lys Glu 
    1025                 1030                 1035             


Cys Glu  Lys Pro Gln Gly Asp  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1040                 1045                 1050             


Glu Val  Glu Glu Glu Glu Val  Glu Glu Ala Glu Asn  Glu Gly Glu 
    1055                 1060                 1065             


Glu Ala  Lys Thr Glu Gly Leu  Met Lys Asp Asp Arg  Ala Glu Ser 
    1070                 1075                 1080             


Gln Ala  Ser Ser Leu Gly Gln  Lys Val Gly Glu Ser  Ser Glu Gln 
    1085                 1090                 1095             


Val Ser  Glu Glu Lys Thr Asn  Glu Ala 
    1100                 1105         


<210> 39
<211> 5733
<212> DNA
<213> Homo sapiens

<400> 39
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacggaa aggaagggca agaaatcctg gggcctgaag ctcaggcaga      120

tgaagcagga tgtacagtaa aagatgatga atgcgagtca gatgcagaaa atgagcaaaa      180

ccatgatcct aatgttgaag agtttctaca acaacaagac actgctgtca tttttcctga      240

ggcacctgaa gaggaccaga ggcagggcac accagaagcc agtggtcatg atgaaaatgg      300

aacaccagat gcattttcac aattactcac ctgtccatat tgtgatagag gctataaacg      360

ctttacctct ctgaaagaac acattaaata tcgtcatgaa aagaatgaag ataactttag      420

ttgctccctg tgcagttaca cctttgcata cagaacccaa cttgaacgtc acatgacatc      480

acataaatca ggaagagatc aaagacatgt gacgcagtct gggtgtaatc gtaaattcaa      540

atgcactgag tgtggaaaag ctttcaaata caaacatcac ctaaaagagc acttaagaat      600

tcacagtgga gagaagccat atgaatgccc aaactgcaag aaacgctttt cccattctgg      660

ctcctatagc tcacacataa gcagtaagaa atgtatcagc ttgatacctg tgaatgggcg      720

accaagaaca ggactcaaga catctcagtg ttcttcaccg tctctttcag catcaccagg      780

cagtcccaca cgaccacaga tacggcaaaa gatagagaat aaaccccttc aagaacaact      840

ttctgttaac caaattaaaa ctgaacctgt ggattatgaa ttcaaaccca tagtggttgc      900

ttcaggaatc aactgttcaa cccctttaca aaatggggtt ttcactggtg gtggcccatt      960

acaggcaacc agttctcctc agggcatggt gcaagctgtt gttctgccaa cagttggttt     1020

ggtgtctccc ataagtatca atttaagtga tattcagaat gtacttaaag tggcggtaga     1080

tggtaatgta ataaggcaag tgttggagaa taatcaagcc aatcttgcat ccaaagaaca     1140

agaaacaatc aatgcttcac ccatacaaca aggtggccat tctgttattt cagccatcag     1200

tcttcctttg gttgatcaag atggaacaac caaaattatc atcaactaca gtcttgagca     1260

gcctagccaa cttcaagttg ttcctcaaaa tttaaaaaaa gaaaatccag tcgctacaaa     1320

cagttgtaaa agtgaaaagt taccagaaga tcttactgtt aagtctgaga aggacaaaag     1380

ctttgaaggg ggggtgaatg atagcacttg tcttctgtgt gatgattgtc caggagatat     1440

taatgcactt ccagaattaa agcactatga cctaaagcag cctactcagc ctcctccact     1500

ccctgcagca gaagctgaga agcctgagtc ctctgtttca tcagctactg gagatggcaa     1560

tttgtctcct agtcagccac ctttaaagaa cctcttgtct ctcctaaaag catattatgc     1620

tttgaatgca caaccaagtg cagaagagct ctcaaaaatt gctgattcag taaacctacc     1680

actggatgta gtaaaaaagt ggtttgaaaa gatgcaagct ggacagattt cagtgcagtc     1740

ttctgaacca tcttctcctg aaccaggcaa agtaaatatc cctgccaaga acaatgatca     1800

gcctcaatct gcaaatgcaa atgaacccca ggacagcaca gtaaatctac aaagtccttt     1860

gaagatgact aactccccag ttttaccagt gggatcaacc accaatggtt ccagaagtag     1920

tacaccatcc ccatcacctc taaacctttc ctcatccaga aatacacagg gttacttgta     1980

cacagctgag ggtgcacaag aagagccaca agtagaacct cttgatcttt cactaccaaa     2040

gcaacaggga gaattattag aaaggtcaac tatcactagt gtttaccaga acagtgttta     2100

ttctgtccag gaagaaccct tgaacttgtc ttgcgcaaaa aaggagccac aaaaggacag     2160

ttgtgttaca gactcagaac cagttgtaaa tgtaatccca ccaagtgcca accccataaa     2220

tatcgctata cctacagtca ctgcccagtt acccacaatc gtggccattg ctgaccagaa     2280

cagtgttcca tgcttaagag cgctagctgc caataagcaa acgattctga ttccccaggt     2340

ggcatacacc tactcaacta cggtcagccc tgcagtccaa gaaccaccct tgaaagtgat     2400

ccagccaaat ggaaatcagg atgaaagaca agatactagc tcagaaggag tatcaaatgt     2460

agaggatcag aatgactctg attctacacc gcccaaaaag aaaatgcgga agacagaaaa     2520

tggaatgtat gcttgtgatt tgtgtgacaa gatattccaa aagagtagtt cattattgag     2580

acataaatat gaacacacag gtaaaagacc tcatgagtgt ggaatctgta aaaaggcatt     2640

taaacacaaa catcatttga ttgaacacat gcgattacat tctggagaaa agccctatca     2700

atgtgacaaa tgtggaaagc gcttctcaca ctctgggtct tattctcaac acatgaatca     2760

tcgctactcc tactgtaaga gagaagcgga agaacgtgac agcacagagc aggaagaggc     2820

agggcctgaa atcctctcga atgagcacgt gggtgccagg gcgtctccct cacagggcga     2880

ctcggacgag agagagagtt tgacaaggga agaggatgaa gacagtgaaa aagaggaaga     2940

ggaggaggat aaagagatgg aagaattgca ggaagaaaaa gaatgtgaaa aaccacaagg     3000

ggatgaggaa gaggaggagg aggaggaaga agtggaagaa gaagaggtag aagaggcaga     3060

gaatgaggga gaagaagcaa aaactgaagg tctgatgaag gatgacaggg ctgaaagtca     3120

agcaagcagc ttaggacaaa aagtaggcga gagtagtgag caagtgtctg aagaaaagac     3180

aaatgaagcc taatcgtttt tctagaagga aaataaattc taattgataa tgaatttcgt     3240

tcaatattat ccttgctttt catggaaaca cagtaacctg tatgctgtga ttcctgttca     3300

ctactgtgta aagtaaaaac taaaaaaata caaaatacaa aacacacaca cacacacaca     3360

cacacacaca cacacacaca caaaataaat ccgggtgtgc ctgaacctca gacctagtaa     3420

tttttcatgc agttttcaaa gttaggaaca agtttgtaac atgcagcaga ttagaaaacc     3480

ttaatgactc agagagcaac aatacaagag gttaaaggaa gctgattaat tagatatgca     3540

tctggcattg ttttatctta tcagtattat cactcttatg ttggtttatt cttaagctgt     3600

acaattggga gaaattttat aattttttat tggtaaacat atgctaaatc cgcttcagta     3660

ttttattatg ttttttaaaa tgtgagaact tctgcactac aaaattccct tcacagagaa     3720

gtataatgta gttccaaccc gtgctaacta ccttttataa attcagtcta gaaggtagta     3780

atttctaata tttagatgtc ttagtagagc gtattatcat ttaaagtgta ttgttagcct     3840

taagaaagca gctgatagaa gaactgaagt ttcttactca cgtggtttaa aatggagttc     3900

aaaagattgc cattgagttc tgattgcagg gactaacaat gttaatctga taaggacagc     3960

aaaatcatca gaatcagtgt ttgtgattgt gtttgaatat gtggtaacat atgaaggata     4020

tgacatgaag ctttgtatct cctttggcct taagcaagac ctgtgtgctg taagtgccat     4080

ttctcagtat tttcaaggct ctaacccgcc ttcatccaat gtgtggccta caataactag     4140

catttgttga tttgtctctt gtatcaaaat tcccaaataa aacttaaaac cactgactct     4200

gtcagagaaa ctgaaacact gggacatttc atccttcaat tcctcggtat tgattttatg     4260

ttgattgatt ttcagaattt ctctacagaa acgaaaggga aattttctaa tctgctttat     4320

ccatgtactt gcatttcaga catggacatg ctattgttat ttggctcata actgtttcca     4380

aatgttagtt attatggacc caatttatta acaacattag ctgattttta cctatcagta     4440

ttattttatt tcttttagtt tatagatctg tgcaacattt ttgtactgta tgtcttcaaa     4500

cctggcagta ttaataccct tcttactgac atatgtactt ttagttttag aaaactttta     4560

tatttatgtg tcttattttt atatttcttt atttattaca cagtgtagtg tataatactg     4620

tagtttgtat taatacaata atatatttta gtatgaaaat ttggaaagtt gataagattt     4680

aaagtagaga tgcaattggt tctcctgcat tgagatttga tttaacagtg ttatgttaac     4740

atttatactt gccttggact gtagaacaga acttaaatgg gaatgtatta gttttacaac     4800

tacaatcaag tcattttacc tttacccagt ttttaatata aaacttaaat tttgaaattc     4860

actgtgtgac taatagcatg atgctctgca gttttattaa gaaatcagcc taaccataca     4920

actctcattt ccttagtaag ccaaattagg attaacttct ataaacagtg ttgggaacaa     4980

tgtttaacat tttgtgccaa tttgttcctg tattcatgta tgtaagttac agatctgact     5040

cttcattttt aagttccttg ttacatcatg gtcattttct agttttttac cagactccca     5100

tctcacaata aaatgcatca acaagcctga actgctgtca ttcttttcat cattatcagt     5160

attttctttg gaaaactgtg aaatggggta cattgtcatc ctgcatttga ttcatcttga     5220

gctgaatttg ggtaacacta aatgttttag acattctcca ctaaattatg gattttcttg     5280

tggctaaatg tttctggaga ggtcagagtt gacaaaacct cttcacaggt tgctccttct     5340

tcctgaaatc cttaatcctc cgcatttcat gcttcaggtc atttcaggga agcctgggtt     5400

tagatgcctt tctgactctc agctcctgca cttctgtcat catacctctg atactattat     5460

ttatattcct tccccactag gaacaggaac cacatttgtc atagtcactc tcacattcct     5520

cactgcctaa cagggtgcct ggcataagtt gggacaacag atatttgttg aataaaaata     5580

taatttgcat gtttatggag ctcagctatg ttctcacttt ttttgcttct aattccagaa     5640

tatatgttaa atgatctaat aatttgatta ttttcttata agtcttatta aacactagtc     5700

ataatagaca caataaatta tgccttcttt ttc                                  5733


<210> 40
<211> 1057
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys Gln Ala Asn Pro Arg 
1               5                   10                  15      


Arg Asn Asn Gly Lys Glu Gly Gln Glu Ile Leu Gly Pro Glu Ala Gln 
            20                  25                  30          


Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp Glu Cys Glu Ser Asp 
        35                  40                  45              


Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu Glu Phe Leu Gln 
    50                  55                  60                  


Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro Glu Glu Asp Gln 
65                  70                  75                  80  


Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu Asn Gly Thr Pro 
                85                  90                  95      


Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys Asp Arg Gly Tyr 
            100                 105                 110         


Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr Arg His Glu Lys 
        115                 120                 125             


Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr Thr Phe Ala Tyr 
    130                 135                 140                 


Arg Thr Gln Leu Glu Arg His Met Thr Ser His Lys Ser Gly Arg Asp 
145                 150                 155                 160 


Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys Phe Lys Cys Thr 
                165                 170                 175     


Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu Lys Glu His Leu 
            180                 185                 190         


Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn Cys Lys Lys 
        195                 200                 205             


Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile Ser Ser Lys Lys 
    210                 215                 220                 


Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg Thr Gly Leu Lys 
225                 230                 235                 240 


Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser Pro Gly Ser Pro 
                245                 250                 255     


Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys Pro Leu Gln Glu 
            260                 265                 270         


Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val Asp Tyr Glu Phe 
        275                 280                 285             


Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser Thr Pro Leu Gln 
    290                 295                 300                 


Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala Thr Ser Ser Pro 
305                 310                 315                 320 


Gln Gly Met Val Gln Ala Val Val Leu Pro Thr Val Gly Leu Val Ser 
                325                 330                 335     


Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val Leu Lys Val Ala 
            340                 345                 350         


Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn Asn Gln Ala Asn 
        355                 360                 365             


Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser Pro Ile Gln Gln 
    370                 375                 380                 


Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro Leu Val Asp Gln 
385                 390                 395                 400 


Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu Glu Gln Pro Ser 
                405                 410                 415     


Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu Asn Pro Val Ala 
            420                 425                 430         


Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp Leu Thr Val Lys 
        435                 440                 445             


Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn Asp Ser Thr Cys 
    450                 455                 460                 


Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala Leu Pro Glu Leu 
465                 470                 475                 480 


Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro Pro Leu Pro Ala 
                485                 490                 495     


Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser Ala Thr Gly Asp 
            500                 505                 510         


Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn Leu Leu Ser Leu 
        515                 520                 525             


Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser Ala Glu Glu Leu 
    530                 535                 540                 


Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp Val Val Lys Lys 
545                 550                 555                 560 


Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val Gln Ser Ser Glu 
                565                 570                 575     


Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro Ala Lys Asn Asn 
            580                 585                 590         


Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln Asp Ser Thr Val 
        595                 600                 605             


Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro Val Leu Pro Val 
    610                 615                 620                 


Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro Ser Pro Ser Pro 
625                 630                 635                 640 


Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr Leu Tyr Thr Ala 
                645                 650                 655     


Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu Asp Leu Ser Leu 
            660                 665                 670         


Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr Ile Thr Ser Val 
        675                 680                 685             


Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro Leu Asn Leu Ser 
    690                 695                 700                 


Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val Thr Asp Ser Glu 
705                 710                 715                 720 


Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro Ile Asn Ile Ala 
                725                 730                 735     


Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val Ala Ile Ala Asp 
            740                 745                 750         


Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala Asn Lys Gln Thr 
        755                 760                 765             


Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr Thr Val Ser Pro 
    770                 775                 780                 


Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro Asn Gly Asn Gln 
785                 790                 795                 800 


Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser Asn Val Glu Asp 
                805                 810                 815     


Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys Met Arg Lys Thr 
            820                 825                 830         


Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Ile Phe Gln Lys 
        835                 840                 845             


Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly Lys Arg Pro 
    850                 855                 860                 


His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His Lys His His Leu 
865                 870                 875                 880 


Ile Glu His Met Arg Leu His Ser Gly Glu Lys Pro Tyr Gln Cys Asp 
                885                 890                 895     


Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Gln His Met 
            900                 905                 910         


Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu Arg Asp Ser 
        915                 920                 925             


Thr Glu Gln Glu Glu Ala Gly Pro Glu Ile Leu Ser Asn Glu His Val 
    930                 935                 940                 


Gly Ala Arg Ala Ser Pro Ser Gln Gly Asp Ser Asp Glu Arg Glu Ser 
945                 950                 955                 960 


Leu Thr Arg Glu Glu Asp Glu Asp Ser Glu Lys Glu Glu Glu Glu Glu 
                965                 970                 975     


Asp Lys Glu Met Glu Glu Leu Gln Glu Glu Lys Glu Cys Glu Lys Pro 
            980                 985                 990         


Gln Gly Asp Glu Glu Glu Glu Glu  Glu Glu Glu Glu Val  Glu Glu Glu 
        995                 1000                 1005             


Glu Val  Glu Glu Ala Glu Asn  Glu Gly Glu Glu Ala  Lys Thr Glu 
    1010                 1015                 1020             


Gly Leu  Met Lys Asp Asp Arg  Ala Glu Ser Gln Ala  Ser Ser Leu 
    1025                 1030                 1035             


Gly Gln  Lys Val Gly Glu Ser  Ser Glu Gln Val Ser  Glu Glu Lys 
    1040                 1045                 1050             


Thr Asn  Glu Ala 
    1055         


<210> 41
<211> 5937
<212> DNA
<213> Homo sapiens

<400> 41
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgtta caaattataa tactgtggta gaaacaaatt cagattcaga      120

tgatgaagac aaactgcata ttgtggaaga agaaagtgtt acagatgcag ctgactgtga      180

aggtgtacca gaggatgacc tgccaacaga ccagacagtg ttaccaggga ggagcagtga      240

aagagaaggg aatgctaaga actgctggga ggatgacaca ggaaaggaag ggcaagaaat      300

cctggggcct gaagctcagg cagatgaagc aggatgtaca gtaaaagatg atgaatgcga      360

gtcagatgca gaaaatgagc aaaaccatga tcctaatgtt gaagagtttc tacaacaaca      420

agacactgct gtcatttttc ctgaggcacc tgaagaggac cagaggcagg gcacaccaga      480

agccagtggt catgatgaaa atggaacacc agatgcattt tcacaattac tcacctgtcc      540

atattgtgat agaggctata aacgctttac ctctctgaaa gaacacatta aatatcgtca      600

tgaaaagaat gaagataact ttagttgctc cctgtgcagt tacacctttg catacagaac      660

ccaacttgaa cgtcacatga catcacataa atcaggaaga gatcaaagac atgtgacgca      720

gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga aaagctttca aatacaaaca      780

tcacctaaaa gagcacttaa gaattcacag tggagagaag ccatatgaat gcccaaactg      840

caagaaacgc ttttcccatt ctggctccta tagctcacac ataagcagta agaaatgtat      900

cagcttgata cctgtgaatg ggcgaccaag aacaggactc aagacatctc agtgttcttc      960

accgtctctt tcagcatcac caggcagtcc cacacgacca cagatacggc aaaagataga     1020

gaataaaccc cttcaagaac aactttctgt taaccaaatt aaaactgaac ctgtggatta     1080

tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt tcaacccctt tacaaaatgg     1140

ggttttcact ggtggtggcc cattacaggc aaccagttct cctcagggca tggtgcaagc     1200

tgttgttctg ccaacagttg gtttggtgtc tcccataagt atcaatttaa gtgatattca     1260

gaatgtactt aaagtggcgg tagatggtaa tgtaataagg caagtgttgg agaataatca     1320

agccaatctt gcatccaaag aacaagaaac aatcaatgct tcacccatac aacaaggtgg     1380

ccattctgtt atttcagcca tcagtcttcc tttggttgat caagatggaa caaccaaaat     1440

tatcatcaac tacagtcttg agcagcctag ccaacttcaa gttgttcctc aaaatttaaa     1500

aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa aagttaccag aagatcttac     1560

tgttaagtct gagaaggaca aaagctttga agggggggtg aatgatagca cttgtcttct     1620

gtgtgatgat tgtccaggag atattaatgc acttccagaa ttaaagcact atgacctaaa     1680

gcagcctact cagcctcctc cactccctgc agcagaagct gagaagcctg agtcctctgt     1740

ttcatcagct actggagatg gcaatttgtc tcctagtcag ccacctttaa agaacctctt     1800

gtctctccta aaagcatatt atgctttgaa tgcacaacca agtgcagaag agctctcaaa     1860

aattgctgat tcagtaaacc taccactgga tgtagtaaaa aagtggtttg aaaagatgca     1920

agctggacag atttcagtgc agtcttctga accatcttct cctgaaccag gcaaagtaaa     1980

tatccctgcc aagaacaatg atcagcctca atctgcaaat gcaaatgaac cccaggacag     2040

cacagtaaat ctacaaagtc ctttgaagat gactaactcc ccagttttac cagtgggatc     2100

aaccaccaat ggttccagaa gtagtacacc atccccatca cctctaaacc tttcctcatc     2160

cagaaataca cagggttact tgtacacagc tgagggtgca caagaagagc cacaagtaga     2220

acctcttgat ctttcactac caaagcaaca gggagaatta ttagaaaggt caactatcac     2280

tagtgtttac cagaacagtg tttattctgt ccaggaagaa cccttgaact tgtcttgcgc     2340

aaaaaaggag ccacaaaagg acagttgtgt tacagactca gaaccagttg taaatgtaat     2400

cccaccaagt gccaacccca taaatatcgc tatacctaca gtcactgccc agttacccac     2460

aatcgtggcc attgctgacc agaacagtgt tccatgctta agagcgctag ctgccaataa     2520

gcaaacgatt ctgattcccc aggtggcata cacctactca actacggtca gccctgcagt     2580

ccaagaacca cccttgaaag tgatccagcc aaatggaaat caggatgaaa gacaagatac     2640

tagctcagaa ggagtatcaa atgtagagga tcagaatgac tctgattcta caccgcccaa     2700

aaagaaaatg cggaagacag aaaatggaat gtatgcttgt gatttgtgtg acaagatatt     2760

ccaaaagagt agttcattat tgagacataa atatgaacac acaggtaaaa gacctcatga     2820

gtgtggaatc tgtaaaaagg catttaaaca caaacatcat ttgattgaac acatgcgatt     2880

acattctgga gaaaagccct atcaatgtga caaatgtgga aagcgcttct cacactctgg     2940

gtcttattct caacacatga atcatcgcta ctcctactgt aagagagaag cggaagaacg     3000

tgacagcaca gagcaggaag aggcagggcc tgaaatcctc tcgaatgagc acgtgggtgc     3060

cagggcgtct ccctcacagg gcgactcgga cgagagagag agtttgacaa gggaagagga     3120

tgaagacagt gaaaaagagg aagaggagga ggataaagag atggaagaat tgcaggaaga     3180

aaaagaatgt gaaaaaccac aaggggatga ggaagaggag gaggaggagg aagaagtgga     3240

agaagaagag gtagaagagg cagagaatga gggagaagaa gcaaaaactg aaggtctgat     3300

gaaggatgac agggctgaaa gtcaagcaag cagcttagga caaaaagtag gcgagagtag     3360

tgagcaagtg tctgaagaaa agacaaatga agcctaatcg tttttctaga aggaaaataa     3420

attctaattg ataatgaatt tcgttcaata ttatccttgc ttttcatgga aacacagtaa     3480

cctgtatgct gtgattcctg ttcactactg tgtaaagtaa aaactaaaaa aatacaaaat     3540

acaaaacaca cacacacaca cacacacaca cacacacaca cacacaaaat aaatccgggt     3600

gtgcctgaac ctcagaccta gtaatttttc atgcagtttt caaagttagg aacaagtttg     3660

taacatgcag cagattagaa aaccttaatg actcagagag caacaataca agaggttaaa     3720

ggaagctgat taattagata tgcatctggc attgttttat cttatcagta ttatcactct     3780

tatgttggtt tattcttaag ctgtacaatt gggagaaatt ttataatttt ttattggtaa     3840

acatatgcta aatccgcttc agtattttat tatgtttttt aaaatgtgag aacttctgca     3900

ctacaaaatt cccttcacag agaagtataa tgtagttcca acccgtgcta actacctttt     3960

ataaattcag tctagaaggt agtaatttct aatatttaga tgtcttagta gagcgtatta     4020

tcatttaaag tgtattgtta gccttaagaa agcagctgat agaagaactg aagtttctta     4080

ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga gttctgattg cagggactaa     4140

caatgttaat ctgataagga cagcaaaatc atcagaatca gtgtttgtga ttgtgtttga     4200

atatgtggta acatatgaag gatatgacat gaagctttgt atctcctttg gccttaagca     4260

agacctgtgt gctgtaagtg ccatttctca gtattttcaa ggctctaacc cgccttcatc     4320

caatgtgtgg cctacaataa ctagcatttg ttgatttgtc tcttgtatca aaattcccaa     4380

ataaaactta aaaccactga ctctgtcaga gaaactgaaa cactgggaca tttcatcctt     4440

caattcctcg gtattgattt tatgttgatt gattttcaga atttctctac agaaacgaaa     4500

gggaaatttt ctaatctgct ttatccatgt acttgcattt cagacatgga catgctattg     4560

ttatttggct cataactgtt tccaaatgtt agttattatg gacccaattt attaacaaca     4620

ttagctgatt tttacctatc agtattattt tatttctttt agtttataga tctgtgcaac     4680

atttttgtac tgtatgtctt caaacctggc agtattaata cccttcttac tgacatatgt     4740

acttttagtt ttagaaaact tttatattta tgtgtcttat ttttatattt ctttatttat     4800

tacacagtgt agtgtataat actgtagttt gtattaatac aataatatat tttagtatga     4860

aaatttggaa agttgataag atttaaagta gagatgcaat tggttctcct gcattgagat     4920

ttgatttaac agtgttatgt taacatttat acttgccttg gactgtagaa cagaacttaa     4980

atgggaatgt attagtttta caactacaat caagtcattt tacctttacc cagtttttaa     5040

tataaaactt aaattttgaa attcactgtg tgactaatag catgatgctc tgcagtttta     5100

ttaagaaatc agcctaacca tacaactctc atttccttag taagccaaat taggattaac     5160

ttctataaac agtgttggga acaatgttta acattttgtg ccaatttgtt cctgtattca     5220

tgtatgtaag ttacagatct gactcttcat ttttaagttc cttgttacat catggtcatt     5280

ttctagtttt ttaccagact cccatctcac aataaaatgc atcaacaagc ctgaactgct     5340

gtcattcttt tcatcattat cagtattttc tttggaaaac tgtgaaatgg ggtacattgt     5400

catcctgcat ttgattcatc ttgagctgaa tttgggtaac actaaatgtt ttagacattc     5460

tccactaaat tatggatttt cttgtggcta aatgtttctg gagaggtcag agttgacaaa     5520

acctcttcac aggttgctcc ttcttcctga aatccttaat cctccgcatt tcatgcttca     5580

ggtcatttca gggaagcctg ggtttagatg cctttctgac tctcagctcc tgcacttctg     5640

tcatcatacc tctgatacta ttatttatat tccttcccca ctaggaacag gaaccacatt     5700

tgtcatagtc actctcacat tcctcactgc ctaacagggt gcctggcata agttgggaca     5760

acagatattt gttgaataaa aatataattt gcatgtttat ggagctcagc tatgttctca     5820

ctttttttgc ttctaattcc agaatatatg ttaaatgatc taataatttg attattttct     5880

tataagtctt attaaacact agtcataata gacacaataa attatgcctt ctttttc        5937


<210> 42
<211> 1125
<212> PRT
<213> Homo sapiens

<400> 42
Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys Gln Ala Asn Pro Arg 
1               5                   10                  15      


Arg Asn Asn Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp 
            20                  25                  30          


Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr 
        35                  40                  45              


Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp 
    50                  55                  60                  


Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys 
65                  70                  75                  80  


Asn Cys Trp Glu Asp Asp Thr Gly Lys Glu Gly Gln Glu Ile Leu Gly 
                85                  90                  95      


Pro Glu Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp Glu 
            100                 105                 110         


Cys Glu Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu 
        115                 120                 125             


Glu Phe Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro 
    130                 135                 140                 


Glu Glu Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu 
145                 150                 155                 160 


Asn Gly Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys 
                165                 170                 175     


Asp Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr 
            180                 185                 190         


Arg His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr 
        195                 200                 205             


Thr Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser His Lys 
    210                 215                 220                 


Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys 
225                 230                 235                 240 


Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu 
                245                 250                 255     


Lys Glu His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro 
            260                 265                 270         


Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile 
        275                 280                 285             


Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg 
    290                 295                 300                 


Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys 
                325                 330                 335     


Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val 
            340                 345                 350         


Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser 
        355                 360                 365             


Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala 
    370                 375                 380                 


Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro Thr Val 
385                 390                 395                 400 


Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val 
                405                 410                 415     


Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn 
            420                 425                 430         


Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser 
        435                 440                 445             


Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro 
    450                 455                 460                 


Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu 
465                 470                 475                 480 


Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu 
                485                 490                 495     


Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp 
            500                 505                 510         


Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn 
        515                 520                 525             


Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala 
    530                 535                 540                 


Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro 
545                 550                 555                 560 


Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser 
                565                 570                 575     


Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn 
            580                 585                 590         


Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser 
        595                 600                 605             


Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp 
    610                 615                 620                 


Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val 
625                 630                 635                 640 


Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro 
                645                 650                 655     


Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln 
            660                 665                 670         


Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro 
        675                 680                 685             


Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro 
    690                 695                 700                 


Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr 
705                 710                 715                 720 


Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu 
                725                 730                 735     


Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr 
            740                 745                 750         


Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro 
        755                 760                 765             


Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val 
    770                 775                 780                 


Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro 
785                 790                 795                 800 


Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val 
                805                 810                 815     


Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala 
            820                 825                 830         


Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr 
        835                 840                 845             


Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro 
    850                 855                 860                 


Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser 
865                 870                 875                 880 


Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys 
                885                 890                 895     


Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys 
            900                 905                 910         


Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr 
        915                 920                 925             


Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His 
    930                 935                 940                 


Lys His His Leu Ile Glu His Met Arg Leu His Ser Gly Glu Lys Pro 
945                 950                 955                 960 


Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr 
                965                 970                 975     


Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu 
            980                 985                 990         


Glu Arg Asp Ser Thr Glu Gln Glu  Glu Ala Gly Pro Glu  Ile Leu Ser 
        995                 1000                 1005             


Asn Glu  His Val Gly Ala Arg  Ala Ser Pro Ser Gln  Gly Asp Ser 
    1010                 1015                 1020             


Asp Glu  Arg Glu Ser Leu Thr  Arg Glu Glu Asp Glu  Asp Ser Glu 
    1025                 1030                 1035             


Lys Glu  Glu Glu Glu Glu Asp  Lys Glu Met Glu Glu  Leu Gln Glu 
    1040                 1045                 1050             


Glu Lys  Glu Cys Glu Lys Pro  Gln Gly Asp Glu Glu  Glu Glu Glu 
    1055                 1060                 1065             


Glu Glu  Glu Glu Val Glu Glu  Glu Glu Val Glu Glu  Ala Glu Asn 
    1070                 1075                 1080             


Glu Gly  Glu Glu Ala Lys Thr  Glu Gly Leu Met Lys  Asp Asp Arg 
    1085                 1090                 1095             


Ala Glu  Ser Gln Ala Ser Ser  Leu Gly Gln Lys Val  Gly Glu Ser 
    1100                 1105                 1110             


Ser Glu  Gln Val Ser Glu Glu  Lys Thr Asn Glu Ala  
    1115                 1120                 1125 


<210> 43
<211> 6706
<212> DNA
<213> Homo sapiens

<400> 43
attccgctct actaaggagg ctgctggcaa gcggaacttc tagcctctct ttcaatccag       60

ctgaagttca atctcattga agtcacttcc catcccggtt cgcttggggg gaaaccaggc      120

gtccctggaa gggaagggaa gggagtccgg gctgcgcggg tcagcccgtc gcctttctga      180

ccgcgtccct acggtttccc ggcatccgcc tccctctccc caccacacct gaggaaaact      240

tttccctcgc ccctcaattc aaattcagca gtgcccacgg ttgccgcaaa ccgcccggtc      300

cctagcaaca aggttccggc cgtagagcga gagcctctag gtgtaaggaa ggtgatgtcg      360

taaagccggg agtgtcgtaa accagttttc agtttaaatt ctcaactggc aattggccga      420

aaactcccat ctgaagacat gatcatccaa atgtcatttt gtgatttggc tactgtctgc      480

ttgacatagg aaagcactat caagaaagac taatggagtg actatcaaaa ggaagtcaat      540

gatttcttaa gaatttacaa caaaaccctg tcaaagcagc attcttacgt gagaatttca      600

cttacgggag agttcttaca ggatttcaag aaggaaagcc ctgaagaggg acactgattt      660

cctcaactga atttaaaatt gttacatgca gacattttta aaggacaacc ttaaacttcc      720

accacaagag gaatataaag aggtccctcc tgcaccaaga aagatctgca gatctttttc      780

agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt tgtgtcagcc accttgttct      840

ctaaagttac aaattataat actgtggtag aaacaaattc agattcagat gatgaagaca      900

aactgcatat tgtggaagaa gaaagtgtta cagatgcagc tgactgtgaa ggtgtaccag      960

aggatgacct gccaacagac cagacagtgt taccagggag gagcagtgaa agagaaggga     1020

atgctaagaa ctgctgggag gatgacacag gaaaggaagg gcaagaaatc ctggggcctg     1080

aagctcaggc agatgaagca ggatgtacag taaaagatga tgaatgcgag tcagatgcag     1140

aaaatgagca aaaccatgat cctaatgttg aagagtttct acaacaacaa gacactgctg     1200

tcatttttcc tgaggcacct gaagaggacc agaggcaggg cacaccagaa gccagtggtc     1260

atgatgaaaa tggaacacca gatgcatttt cacaattact cacctgtcca tattgtgata     1320

gaggctataa acgctttacc tctctgaaag aacacattaa atatcgtcat gaaaagaatg     1380

aagataactt tagttgctcc ctgtgcagtt acacctttgc atacagaacc caacttgaac     1440

gtcacatgac atcacataaa tcaggaagag atcaaagaca tgtgacgcag tctgggtgta     1500

atcgtaaatt caaatgcact gagtgtggaa aagctttcaa atacaaacat cacctaaaag     1560

agcacttaag aattcacagt ggagagaagc catatgaatg cccaaactgc aagaaacgct     1620

tttcccattc tggctcctat agctcacaca taagcagtaa gaaatgtatc agcttgatac     1680

ctgtgaatgg gcgaccaaga acaggactca agacatctca gtgttcttca ccgtctcttt     1740

cagcatcacc aggcagtccc acacgaccac agatacggca aaagatagag aataaacccc     1800

ttcaagaaca actttctgtt aaccaaatta aaactgaacc tgtggattat gaattcaaac     1860

ccatagtggt tgcttcagga atcaactgtt caaccccttt acaaaatggg gttttcactg     1920

gtggtggccc attacaggca accagttctc ctcagggcat ggtgcaagct gttgttctgc     1980

caacagttgg tttggtgtct cccataagta tcaatttaag tgatattcag aatgtactta     2040

aagtggcggt agatggtaat gtaataaggc aagtgttgga gaataatcaa gccaatcttg     2100

catccaaaga acaagaaaca atcaatgctt cacccataca acaaggtggc cattctgtta     2160

tttcagccat cagtcttcct ttggttgatc aagatggaac aaccaaaatt atcatcaact     2220

acagtcttga gcagcctagc caacttcaag ttgttcctca aaatttaaaa aaagaaaatc     2280

cagtcgctac aaacagttgt aaaagtgaaa agttaccaga agatcttact gttaagtctg     2340

agaaggacaa aagctttgaa gggggggtga atgatagcac ttgtcttctg tgtgatgatt     2400

gtccaggaga tattaatgca cttccagaat taaagcacta tgacctaaag cagcctactc     2460

agcctcctcc actccctgca gcagaagctg agaagcctga gtcctctgtt tcatcagcta     2520

ctggagatgg caatttgtct cctagtcagc cacctttaaa gaacctcttg tctctcctaa     2580

aagcatatta tgctttgaat gcacaaccaa gtgcagaaga gctctcaaaa attgctgatt     2640

cagtaaacct accactggat gtagtaaaaa agtggtttga aaagatgcaa gctggacaga     2700

tttcagtgca gtcttctgaa ccatcttctc ctgaaccagg caaagtaaat atccctgcca     2760

agaacaatga tcagcctcaa tctgcaaatg caaatgaacc ccaggacagc acagtaaatc     2820

tacaaagtcc tttgaagatg actaactccc cagttttacc agtgggatca accaccaatg     2880

gttccagaag tagtacacca tccccatcac ctctaaacct ttcctcatcc agaaatacac     2940

agggttactt gtacacagct gagggtgcac aagaagagcc acaagtagaa cctcttgatc     3000

tttcactacc aaagcaacag ggagaattat tagaaaggtc aactatcact agtgtttacc     3060

agaacagtgt ttattctgtc caggaagaac ccttgaactt gtcttgcgca aaaaaggagc     3120

cacaaaagga cagttgtgtt acagactcag aaccagttgt aaatgtaatc ccaccaagtg     3180

ccaaccccat aaatatcgct atacctacag tcactgccca gttacccaca atcgtggcca     3240

ttgctgacca gaacagtgtt ccatgcttaa gagcgctagc tgccaataag caaacgattc     3300

tgattcccca ggtggcatac acctactcaa ctacggtcag ccctgcagtc caagaaccac     3360

ccttgaaagt gatccagcca aatggaaatc aggatgaaag acaagatact agctcagaag     3420

gagtatcaaa tgtagaggat cagaatgact ctgattctac accgcccaaa aagaaaatgc     3480

ggaagacaga aaatggaatg tatgcttgtg atttgtgtga caagatattc caaaagagta     3540

gttcattatt gagacataaa tatgaacaca caggtaaaag acctcatgag tgtggaatct     3600

gtaaaaaggc atttaaacac aaacatcatt tgattgaaca catgcgatta cattctggag     3660

aaaagcccta tcaatgtgac aaatgtggaa agcgcttctc acactctggg tcttattctc     3720

aacacatgaa tcatcgctac tcctactgta agagagaagc ggaagaacgt gacagcacag     3780

agcaggaaga ggcagggcct gaaatcctct cgaatgagca cgtgggtgcc agggcgtctc     3840

cctcacaggg cgactcggac gagagagaga gtttgacaag ggaagaggat gaagacagtg     3900

aaaaagagga agaggaggag gataaagaga tggaagaatt gcaggaagaa aaagaatgtg     3960

aaaaaccaca aggggatgag gaagaggagg aggaggagga agaagtggaa gaagaagagg     4020

tagaagaggc agagaatgag ggagaagaag caaaaactga aggtctgatg aaggatgaca     4080

gggctgaaag tcaagcaagc agcttaggac aaaaagtagg cgagagtagt gagcaagtgt     4140

ctgaagaaaa gacaaatgaa gcctaatcgt ttttctagaa ggaaaataaa ttctaattga     4200

taatgaattt cgttcaatat tatccttgct tttcatggaa acacagtaac ctgtatgctg     4260

tgattcctgt tcactactgt gtaaagtaaa aactaaaaaa atacaaaata caaaacacac     4320

acacacacac acacacacac acacacacac acacaaaata aatccgggtg tgcctgaacc     4380

tcagacctag taatttttca tgcagttttc aaagttagga acaagtttgt aacatgcagc     4440

agattagaaa accttaatga ctcagagagc aacaatacaa gaggttaaag gaagctgatt     4500

aattagatat gcatctggca ttgttttatc ttatcagtat tatcactctt atgttggttt     4560

attcttaagc tgtacaattg ggagaaattt tataattttt tattggtaaa catatgctaa     4620

atccgcttca gtattttatt atgtttttta aaatgtgaga acttctgcac tacaaaattc     4680

ccttcacaga gaagtataat gtagttccaa cccgtgctaa ctacctttta taaattcagt     4740

ctagaaggta gtaatttcta atatttagat gtcttagtag agcgtattat catttaaagt     4800

gtattgttag ccttaagaaa gcagctgata gaagaactga agtttcttac tcacgtggtt     4860

taaaatggag ttcaaaagat tgccattgag ttctgattgc agggactaac aatgttaatc     4920

tgataaggac agcaaaatca tcagaatcag tgtttgtgat tgtgtttgaa tatgtggtaa     4980

catatgaagg atatgacatg aagctttgta tctcctttgg ccttaagcaa gacctgtgtg     5040

ctgtaagtgc catttctcag tattttcaag gctctaaccc gccttcatcc aatgtgtggc     5100

ctacaataac tagcatttgt tgatttgtct cttgtatcaa aattcccaaa taaaacttaa     5160

aaccactgac tctgtcagag aaactgaaac actgggacat ttcatccttc aattcctcgg     5220

tattgatttt atgttgattg attttcagaa tttctctaca gaaacgaaag ggaaattttc     5280

taatctgctt tatccatgta cttgcatttc agacatggac atgctattgt tatttggctc     5340

ataactgttt ccaaatgtta gttattatgg acccaattta ttaacaacat tagctgattt     5400

ttacctatca gtattatttt atttctttta gtttatagat ctgtgcaaca tttttgtact     5460

gtatgtcttc aaacctggca gtattaatac ccttcttact gacatatgta cttttagttt     5520

tagaaaactt ttatatttat gtgtcttatt tttatatttc tttatttatt acacagtgta     5580

gtgtataata ctgtagtttg tattaataca ataatatatt ttagtatgaa aatttggaaa     5640

gttgataaga tttaaagtag agatgcaatt ggttctcctg cattgagatt tgatttaaca     5700

gtgttatgtt aacatttata cttgccttgg actgtagaac agaacttaaa tgggaatgta     5760

ttagttttac aactacaatc aagtcatttt acctttaccc agtttttaat ataaaactta     5820

aattttgaaa ttcactgtgt gactaatagc atgatgctct gcagttttat taagaaatca     5880

gcctaaccat acaactctca tttccttagt aagccaaatt aggattaact tctataaaca     5940

gtgttgggaa caatgtttaa cattttgtgc caatttgttc ctgtattcat gtatgtaagt     6000

tacagatctg actcttcatt tttaagttcc ttgttacatc atggtcattt tctagttttt     6060

taccagactc ccatctcaca ataaaatgca tcaacaagcc tgaactgctg tcattctttt     6120

catcattatc agtattttct ttggaaaact gtgaaatggg gtacattgtc atcctgcatt     6180

tgattcatct tgagctgaat ttgggtaaca ctaaatgttt tagacattct ccactaaatt     6240

atggattttc ttgtggctaa atgtttctgg agaggtcaga gttgacaaaa cctcttcaca     6300

ggttgctcct tcttcctgaa atccttaatc ctccgcattt catgcttcag gtcatttcag     6360

ggaagcctgg gtttagatgc ctttctgact ctcagctcct gcacttctgt catcatacct     6420

ctgatactat tatttatatt ccttccccac taggaacagg aaccacattt gtcatagtca     6480

ctctcacatt cctcactgcc taacagggtg cctggcataa gttgggacaa cagatatttg     6540

ttgaataaaa atataatttg catgtttatg gagctcagct atgttctcac tttttttgct     6600

tctaattcca gaatatatgt taaatgatct aataatttga ttattttctt ataagtctta     6660

ttaaacacta gtcataatag acacaataaa ttatgccttc tttttc                    6706


<210> 44
<211> 906
<212> PRT
<213> Homo sapiens

<400> 44
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 45
<211> 6173
<212> DNA
<213> Homo sapiens

<400> 45
agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg       60

ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc      120

tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg      180

cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac      240

aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg      300

gagtgtcgta aaccagttac aaattataat actgtggtag aaacaaattc agattcagat      360

gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc tgactgtgaa      420

ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag gagcagtgaa      480

agagaaggga atgctaagaa ctgctgggag gatgacagaa aggaagggca agaaatcctg      540

gggcctgaag ctcaggcaga tgaagcagga tgtacagtaa aagatgatga atgcgagtca      600

gatgcagaaa atgagcaaaa ccatgatcct aatgttgaag agtttctaca acaacaagac      660

actgctgtca tttttcctga ggcacctgaa gaggaccaga ggcagggcac accagaagcc      720

agtggtcatg atgaaaatgg aacaccagat gcattttcac aattactcac ctgtccatat      780

tgtgatagag gctataaacg ctttacctct ctgaaagaac acattaaata tcgtcatgaa      840

aagaatgaag ataactttag ttgctccctg tgcagttaca cctttgcata cagaacccaa      900

cttgaacgtc acatgacatc acataaatca ggaagagatc aaagacatgt gacgcagtct      960

gggtgtaatc gtaaattcaa atgcactgag tgtggaaaag ctttcaaata caaacatcac     1020

ctaaaagagc acttaagaat tcacagtgga gagaagccat atgaatgccc aaactgcaag     1080

aaacgctttt cccattctgg ctcctatagc tcacacataa gcagtaagaa atgtatcagc     1140

ttgatacctg tgaatgggcg accaagaaca ggactcaaga catctcagtg ttcttcaccg     1200

tctctttcag catcaccagg cagtcccaca cgaccacaga tacggcaaaa gatagagaat     1260

aaaccccttc aagaacaact ttctgttaac caaattaaaa ctgaacctgt ggattatgaa     1320

ttcaaaccca tagtggttgc ttcaggaatc aactgttcaa cccctttaca aaatggggtt     1380

ttcactggtg gtggcccatt acaggcaacc agttctcctc agggcatggt gcaagctgtt     1440

gttctgccaa cagttggttt ggtgtctccc ataagtatca atttaagtga tattcagaat     1500

gtacttaaag tggcggtaga tggtaatgta ataaggcaag tgttggagaa taatcaagcc     1560

aatcttgcat ccaaagaaca agaaacaatc aatgcttcac ccatacaaca aggtggccat     1620

tctgttattt cagccatcag tcttcctttg gttgatcaag atggaacaac caaaattatc     1680

atcaactaca gtcttgagca gcctagccaa cttcaagttg ttcctcaaaa tttaaaaaaa     1740

gaaaatccag tcgctacaaa cagttgtaaa agtgaaaagt taccagaaga tcttactgtt     1800

aagtctgaga aggacaaaag ctttgaaggg ggggtgaatg atagcacttg tcttctgtgt     1860

gatgattgtc caggagatat taatgcactt ccagaattaa agcactatga cctaaagcag     1920

cctactcagc ctcctccact ccctgcagca gaagctgaga agcctgagtc ctctgtttca     1980

tcagctactg gagatggcaa tttgtctcct agtcagccac ctttaaagaa cctcttgtct     2040

ctcctaaaag catattatgc tttgaatgca caaccaagtg cagaagagct ctcaaaaatt     2100

gctgattcag taaacctacc actggatgta gtaaaaaagt ggtttgaaaa gatgcaagct     2160

ggacagattt cagtgcagtc ttctgaacca tcttctcctg aaccaggcaa agtaaatatc     2220

cctgccaaga acaatgatca gcctcaatct gcaaatgcaa atgaacccca ggacagcaca     2280

gtaaatctac aaagtccttt gaagatgact aactccccag ttttaccagt gggatcaacc     2340

accaatggtt ccagaagtag tacaccatcc ccatcacctc taaacctttc ctcatccaga     2400

aatacacagg gttacttgta cacagctgag ggtgcacaag aagagccaca agtagaacct     2460

cttgatcttt cactaccaaa gcaacaggga gaattattag aaaggtcaac tatcactagt     2520

gtttaccaga acagtgttta ttctgtccag gaagaaccct tgaacttgtc ttgcgcaaaa     2580

aaggagccac aaaaggacag ttgtgttaca gactcagaac cagttgtaaa tgtaatccca     2640

ccaagtgcca accccataaa tatcgctata cctacagtca ctgcccagtt acccacaatc     2700

gtggccattg ctgaccagaa cagtgttcca tgcttaagag cgctagctgc caataagcaa     2760

acgattctga ttccccaggt ggcatacacc tactcaacta cggtcagccc tgcagtccaa     2820

gaaccaccct tgaaagtgat ccagccaaat ggaaatcagg atgaaagaca agatactagc     2880

tcagaaggag tatcaaatgt agaggatcag aatgactctg attctacacc gcccaaaaag     2940

aaaatgcgga agacagaaaa tggaatgtat gcttgtgatt tgtgtgacaa gatattccaa     3000

aagagtagtt cattattgag acataaatat gaacacacag gtaaaagacc tcatgagtgt     3060

ggaatctgta aaaaggcatt taaacacaaa catcatttga ttgaacacat gcgattacat     3120

tctggagaaa agccctatca atgtgacaaa tgtggaaagc gcttctcaca ctctgggtct     3180

tattctcaac acatgaatca tcgctactcc tactgtaaga gagaagcgga agaacgtgac     3240

agcacagagc aggaagaggc agggcctgaa atcctctcga atgagcacgt gggtgccagg     3300

gcgtctccct cacagggcga ctcggacgag agagagagtt tgacaaggga agaggatgaa     3360

gacagtgaaa aagaggaaga ggaggaggat aaagagatgg aagaattgca ggaagaaaaa     3420

gaatgtgaaa aaccacaagg ggatgaggaa gaggaggagg aggaggaaga agtggaagaa     3480

gaagaggtag aagaggcaga gaatgaggga gaagaagcaa aaactgaagg tctgatgaag     3540

gatgacaggg ctgaaagtca agcaagcagc ttaggacaaa aagtaggcga gagtagtgag     3600

caagtgtctg aagaaaagac aaatgaagcc taatcgtttt tctagaagga aaataaattc     3660

taattgataa tgaatttcgt tcaatattat ccttgctttt catggaaaca cagtaacctg     3720

tatgctgtga ttcctgttca ctactgtgta aagtaaaaac taaaaaaata caaaatacaa     3780

aacacacaca cacacacaca cacacacaca cacacacaca caaaataaat ccgggtgtgc     3840

ctgaacctca gacctagtaa tttttcatgc agttttcaaa gttaggaaca agtttgtaac     3900

atgcagcaga ttagaaaacc ttaatgactc agagagcaac aatacaagag gttaaaggaa     3960

gctgattaat tagatatgca tctggcattg ttttatctta tcagtattat cactcttatg     4020

ttggtttatt cttaagctgt acaattggga gaaattttat aattttttat tggtaaacat     4080

atgctaaatc cgcttcagta ttttattatg ttttttaaaa tgtgagaact tctgcactac     4140

aaaattccct tcacagagaa gtataatgta gttccaaccc gtgctaacta ccttttataa     4200

attcagtcta gaaggtagta atttctaata tttagatgtc ttagtagagc gtattatcat     4260

ttaaagtgta ttgttagcct taagaaagca gctgatagaa gaactgaagt ttcttactca     4320

cgtggtttaa aatggagttc aaaagattgc cattgagttc tgattgcagg gactaacaat     4380

gttaatctga taaggacagc aaaatcatca gaatcagtgt ttgtgattgt gtttgaatat     4440

gtggtaacat atgaaggata tgacatgaag ctttgtatct cctttggcct taagcaagac     4500

ctgtgtgctg taagtgccat ttctcagtat tttcaaggct ctaacccgcc ttcatccaat     4560

gtgtggccta caataactag catttgttga tttgtctctt gtatcaaaat tcccaaataa     4620

aacttaaaac cactgactct gtcagagaaa ctgaaacact gggacatttc atccttcaat     4680

tcctcggtat tgattttatg ttgattgatt ttcagaattt ctctacagaa acgaaaggga     4740

aattttctaa tctgctttat ccatgtactt gcatttcaga catggacatg ctattgttat     4800

ttggctcata actgtttcca aatgttagtt attatggacc caatttatta acaacattag     4860

ctgattttta cctatcagta ttattttatt tcttttagtt tatagatctg tgcaacattt     4920

ttgtactgta tgtcttcaaa cctggcagta ttaataccct tcttactgac atatgtactt     4980

ttagttttag aaaactttta tatttatgtg tcttattttt atatttcttt atttattaca     5040

cagtgtagtg tataatactg tagtttgtat taatacaata atatatttta gtatgaaaat     5100

ttggaaagtt gataagattt aaagtagaga tgcaattggt tctcctgcat tgagatttga     5160

tttaacagtg ttatgttaac atttatactt gccttggact gtagaacaga acttaaatgg     5220

gaatgtatta gttttacaac tacaatcaag tcattttacc tttacccagt ttttaatata     5280

aaacttaaat tttgaaattc actgtgtgac taatagcatg atgctctgca gttttattaa     5340

gaaatcagcc taaccataca actctcattt ccttagtaag ccaaattagg attaacttct     5400

ataaacagtg ttgggaacaa tgtttaacat tttgtgccaa tttgttcctg tattcatgta     5460

tgtaagttac agatctgact cttcattttt aagttccttg ttacatcatg gtcattttct     5520

agttttttac cagactccca tctcacaata aaatgcatca acaagcctga actgctgtca     5580

ttcttttcat cattatcagt attttctttg gaaaactgtg aaatggggta cattgtcatc     5640

ctgcatttga ttcatcttga gctgaatttg ggtaacacta aatgttttag acattctcca     5700

ctaaattatg gattttcttg tggctaaatg tttctggaga ggtcagagtt gacaaaacct     5760

cttcacaggt tgctccttct tcctgaaatc cttaatcctc cgcatttcat gcttcaggtc     5820

atttcaggga agcctgggtt tagatgcctt tctgactctc agctcctgca cttctgtcat     5880

catacctctg atactattat ttatattcct tccccactag gaacaggaac cacatttgtc     5940

atagtcactc tcacattcct cactgcctaa cagggtgcct ggcataagtt gggacaacag     6000

atatttgttg aataaaaata taatttgcat gtttatggag ctcagctatg ttctcacttt     6060

ttttgcttct aattccagaa tatatgttaa atgatctaat aatttgatta ttttcttata     6120

agtcttatta aacactagtc ataatagaca caataaatta tgccttcttt ttc            6173


<210> 46
<211> 906
<212> PRT
<213> Homo sapiens

<400> 46
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 47
<211> 6475
<212> DNA
<213> Homo sapiens

<400> 47
agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg       60

ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc      120

tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg      180

cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac      240

aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg      300

gagtgtcgta aaccagtttt cagtttaaat tctcaactgg caattggccg aaaactccca      360

tctgaagaca tgatcatcca aatgtcattt tgtgatttgg ctactgtctg cttgacatag      420

gaaagcacta tcaagaaaga ctaatggagt gactatcaaa aggaagtcaa tggacaacct      480

taaacttcca ccacaagagg aatataaaga ggtccctcct gcaccaagaa agatctgcag      540

atctttttca gtgttcttgg aggtgtgggg tgtgagaact tgatcagttt gtgtcagcca      600

ccttgttctc taaagttaca aattataata ctgtggtaga aacaaattca gattcagatg      660

atgaagacaa actgcatatt gtggaagaag aaagtgttac agatgcagct gactgtgaag      720

gtgtaccaga ggatgacctg ccaacagacc agacagtgtt accagggagg agcagtgaaa      780

gagaagggaa tgctaagaac tgctgggagg atgacacagg aaaggaaggg caagaaatcc      840

tggggcctga agctcaggca gatgaagcag gatgtacagt aaaagatgat gaatgcgagt      900

cagatgcaga aaatgagcaa aaccatgatc ctaatgttga agagtttcta caacaacaag      960

acactgctgt catttttcct gaggcacctg aagaggacca gaggcagggc acaccagaag     1020

ccagtggtca tgatgaaaat ggaacaccag atgcattttc acaattactc acctgtccat     1080

attgtgatag aggctataaa cgctttacct ctctgaaaga acacattaaa tatcgtcatg     1140

aaaagaatga agataacttt agttgctccc tgtgcagtta cacctttgca tacagaaccc     1200

aacttgaacg tcacatgaca tcacataaat caggaagaga tcaaagacat gtgacgcagt     1260

ctgggtgtaa tcgtaaattc aaatgcactg agtgtggaaa agctttcaaa tacaaacatc     1320

acctaaaaga gcacttaaga attcacagtg gagagaagcc atatgaatgc ccaaactgca     1380

agaaacgctt ttcccattct ggctcctata gctcacacat aagcagtaag aaatgtatca     1440

gcttgatacc tgtgaatggg cgaccaagaa caggactcaa gacatctcag tgttcttcac     1500

cgtctctttc agcatcacca ggcagtccca cacgaccaca gatacggcaa aagatagaga     1560

ataaacccct tcaagaacaa ctttctgtta accaaattaa aactgaacct gtggattatg     1620

aattcaaacc catagtggtt gcttcaggaa tcaactgttc aaccccttta caaaatgggg     1680

ttttcactgg tggtggccca ttacaggcaa ccagttctcc tcagggcatg gtgcaagctg     1740

ttgttctgcc aacagttggt ttggtgtctc ccataagtat caatttaagt gatattcaga     1800

atgtacttaa agtggcggta gatggtaatg taataaggca agtgttggag aataatcaag     1860

ccaatcttgc atccaaagaa caagaaacaa tcaatgcttc acccatacaa caaggtggcc     1920

attctgttat ttcagccatc agtcttcctt tggttgatca agatggaaca accaaaatta     1980

tcatcaacta cagtcttgag cagcctagcc aacttcaagt tgttcctcaa aatttaaaaa     2040

aagaaaatcc agtcgctaca aacagttgta aaagtgaaaa gttaccagaa gatcttactg     2100

ttaagtctga gaaggacaaa agctttgaag ggggggtgaa tgatagcact tgtcttctgt     2160

gtgatgattg tccaggagat attaatgcac ttccagaatt aaagcactat gacctaaagc     2220

agcctactca gcctcctcca ctccctgcag cagaagctga gaagcctgag tcctctgttt     2280

catcagctac tggagatggc aatttgtctc ctagtcagcc acctttaaag aacctcttgt     2340

ctctcctaaa agcatattat gctttgaatg cacaaccaag tgcagaagag ctctcaaaaa     2400

ttgctgattc agtaaaccta ccactggatg tagtaaaaaa gtggtttgaa aagatgcaag     2460

ctggacagat ttcagtgcag tcttctgaac catcttctcc tgaaccaggc aaagtaaata     2520

tccctgccaa gaacaatgat cagcctcaat ctgcaaatgc aaatgaaccc caggacagca     2580

cagtaaatct acaaagtcct ttgaagatga ctaactcccc agttttacca gtgggatcaa     2640

ccaccaatgg ttccagaagt agtacaccat ccccatcacc tctaaacctt tcctcatcca     2700

gaaatacaca gggttacttg tacacagctg agggtgcaca agaagagcca caagtagaac     2760

ctcttgatct ttcactacca aagcaacagg gagaattatt agaaaggtca actatcacta     2820

gtgtttacca gaacagtgtt tattctgtcc aggaagaacc cttgaacttg tcttgcgcaa     2880

aaaaggagcc acaaaaggac agttgtgtta cagactcaga accagttgta aatgtaatcc     2940

caccaagtgc caaccccata aatatcgcta tacctacagt cactgcccag ttacccacaa     3000

tcgtggccat tgctgaccag aacagtgttc catgcttaag agcgctagct gccaataagc     3060

aaacgattct gattccccag gtggcataca cctactcaac tacggtcagc cctgcagtcc     3120

aagaaccacc cttgaaagtg atccagccaa atggaaatca ggatgaaaga caagatacta     3180

gctcagaagg agtatcaaat gtagaggatc agaatgactc tgattctaca ccgcccaaaa     3240

agaaaatgcg gaagacagaa aatggaatgt atgcttgtga tttgtgtgac aagatattcc     3300

aaaagagtag ttcattattg agacataaat atgaacacac aggtaaaaga cctcatgagt     3360

gtggaatctg taaaaaggca tttaaacaca aacatcattt gattgaacac atgcgattac     3420

attctggaga aaagccctat caatgtgaca aatgtggaaa gcgcttctca cactctgggt     3480

cttattctca acacatgaat catcgctact cctactgtaa gagagaagcg gaagaacgtg     3540

acagcacaga gcaggaagag gcagggcctg aaatcctctc gaatgagcac gtgggtgcca     3600

gggcgtctcc ctcacagggc gactcggacg agagagagag tttgacaagg gaagaggatg     3660

aagacagtga aaaagaggaa gaggaggagg ataaagagat ggaagaattg caggaagaaa     3720

aagaatgtga aaaaccacaa ggggatgagg aagaggagga ggaggaggaa gaagtggaag     3780

aagaagaggt agaagaggca gagaatgagg gagaagaagc aaaaactgaa ggtctgatga     3840

aggatgacag ggctgaaagt caagcaagca gcttaggaca aaaagtaggc gagagtagtg     3900

agcaagtgtc tgaagaaaag acaaatgaag cctaatcgtt tttctagaag gaaaataaat     3960

tctaattgat aatgaatttc gttcaatatt atccttgctt ttcatggaaa cacagtaacc     4020

tgtatgctgt gattcctgtt cactactgtg taaagtaaaa actaaaaaaa tacaaaatac     4080

aaaacacaca cacacacaca cacacacaca cacacacaca cacaaaataa atccgggtgt     4140

gcctgaacct cagacctagt aatttttcat gcagttttca aagttaggaa caagtttgta     4200

acatgcagca gattagaaaa ccttaatgac tcagagagca acaatacaag aggttaaagg     4260

aagctgatta attagatatg catctggcat tgttttatct tatcagtatt atcactctta     4320

tgttggttta ttcttaagct gtacaattgg gagaaatttt ataatttttt attggtaaac     4380

atatgctaaa tccgcttcag tattttatta tgttttttaa aatgtgagaa cttctgcact     4440

acaaaattcc cttcacagag aagtataatg tagttccaac ccgtgctaac taccttttat     4500

aaattcagtc tagaaggtag taatttctaa tatttagatg tcttagtaga gcgtattatc     4560

atttaaagtg tattgttagc cttaagaaag cagctgatag aagaactgaa gtttcttact     4620

cacgtggttt aaaatggagt tcaaaagatt gccattgagt tctgattgca gggactaaca     4680

atgttaatct gataaggaca gcaaaatcat cagaatcagt gtttgtgatt gtgtttgaat     4740

atgtggtaac atatgaagga tatgacatga agctttgtat ctcctttggc cttaagcaag     4800

acctgtgtgc tgtaagtgcc atttctcagt attttcaagg ctctaacccg ccttcatcca     4860

atgtgtggcc tacaataact agcatttgtt gatttgtctc ttgtatcaaa attcccaaat     4920

aaaacttaaa accactgact ctgtcagaga aactgaaaca ctgggacatt tcatccttca     4980

attcctcggt attgatttta tgttgattga ttttcagaat ttctctacag aaacgaaagg     5040

gaaattttct aatctgcttt atccatgtac ttgcatttca gacatggaca tgctattgtt     5100

atttggctca taactgtttc caaatgttag ttattatgga cccaatttat taacaacatt     5160

agctgatttt tacctatcag tattatttta tttcttttag tttatagatc tgtgcaacat     5220

ttttgtactg tatgtcttca aacctggcag tattaatacc cttcttactg acatatgtac     5280

ttttagtttt agaaaacttt tatatttatg tgtcttattt ttatatttct ttatttatta     5340

cacagtgtag tgtataatac tgtagtttgt attaatacaa taatatattt tagtatgaaa     5400

atttggaaag ttgataagat ttaaagtaga gatgcaattg gttctcctgc attgagattt     5460

gatttaacag tgttatgtta acatttatac ttgccttgga ctgtagaaca gaacttaaat     5520

gggaatgtat tagttttaca actacaatca agtcatttta cctttaccca gtttttaata     5580

taaaacttaa attttgaaat tcactgtgtg actaatagca tgatgctctg cagttttatt     5640

aagaaatcag cctaaccata caactctcat ttccttagta agccaaatta ggattaactt     5700

ctataaacag tgttgggaac aatgtttaac attttgtgcc aatttgttcc tgtattcatg     5760

tatgtaagtt acagatctga ctcttcattt ttaagttcct tgttacatca tggtcatttt     5820

ctagtttttt accagactcc catctcacaa taaaatgcat caacaagcct gaactgctgt     5880

cattcttttc atcattatca gtattttctt tggaaaactg tgaaatgggg tacattgtca     5940

tcctgcattt gattcatctt gagctgaatt tgggtaacac taaatgtttt agacattctc     6000

cactaaatta tggattttct tgtggctaaa tgtttctgga gaggtcagag ttgacaaaac     6060

ctcttcacag gttgctcctt cttcctgaaa tccttaatcc tccgcatttc atgcttcagg     6120

tcatttcagg gaagcctggg tttagatgcc tttctgactc tcagctcctg cacttctgtc     6180

atcatacctc tgatactatt atttatattc cttccccact aggaacagga accacatttg     6240

tcatagtcac tctcacattc ctcactgcct aacagggtgc ctggcataag ttgggacaac     6300

agatatttgt tgaataaaaa tataatttgc atgtttatgg agctcagcta tgttctcact     6360

ttttttgctt ctaattccag aatatatgtt aaatgatcta ataatttgat tattttctta     6420

taagtcttat taaacactag tcataataga cacaataaat tatgccttct ttttc          6475


<210> 48
<211> 906
<212> PRT
<213> Homo sapiens

<400> 48
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 49
<211> 6366
<212> DNA
<213> Homo sapiens

<400> 49
attccgctct actaaggagg ctgctggcaa gcggaacttc tagcctctct ttcaatccag       60

ctgaagttca atctcattga agtcacttcc catcccggtt cgcttggggg gaaaccaggc      120

gtccctggaa gggaagggaa gggagtccgg gctgcgcggg tcagcccgtc gcctttctga      180

ccgcgtccct acggtttccc ggcatccgcc tccctctccc caccacacct gaggaaaact      240

tttccctcgc ccctcaattc aaattcagca gtgcccacgg ttgccgcaaa ccgcccggtc      300

cctagcaaca aggttccggc cgtagagcga gagcctctag gtgtaaggaa ggtgatgtcg      360

taaagccggg agtgtcgtaa accagggaaa cacacacccc tctgcctggc gtgagagtta      420

aaaaaaaaga gagacagccc gagggatcga gacctgaaca tgtggtggtg gttgcacagt      480

cgccttttcc agtttggaga gacgttttac aaattataat actgtggtag aaacaaattc      540

agattcagat gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc      600

tgactgtgaa ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag      660

gagcagtgaa agagaaggga atgctaagaa ctgctgggag gatgacacag gaaaggaagg      720

gcaagaaatc ctggggcctg aagctcaggc agatgaagca ggatgtacag taaaagatga      780

tgaatgcgag tcagatgcag aaaatgagca aaaccatgat cctaatgttg aagagtttct      840

acaacaacaa gacactgctg tcatttttcc tgaggcacct gaagaggacc agaggcaggg      900

cacaccagaa gccagtggtc atgatgaaaa tggaacacca gatgcatttt cacaattact      960

cacctgtcca tattgtgata gaggctataa acgctttacc tctctgaaag aacacattaa     1020

atatcgtcat gaaaagaatg aagataactt tagttgctcc ctgtgcagtt acacctttgc     1080

atacagaacc caacttgaac gtcacatgac atcacataaa tcaggaagag atcaaagaca     1140

tgtgacgcag tctgggtgta atcgtaaatt caaatgcact gagtgtggaa aagctttcaa     1200

atacaaacat cacctaaaag agcacttaag aattcacagt ggagagaagc catatgaatg     1260

cccaaactgc aagaaacgct tttcccattc tggctcctat agctcacaca taagcagtaa     1320

gaaatgtatc agcttgatac ctgtgaatgg gcgaccaaga acaggactca agacatctca     1380

gtgttcttca ccgtctcttt cagcatcacc aggcagtccc acacgaccac agatacggca     1440

aaagatagag aataaacccc ttcaagaaca actttctgtt aaccaaatta aaactgaacc     1500

tgtggattat gaattcaaac ccatagtggt tgcttcagga atcaactgtt caaccccttt     1560

acaaaatggg gttttcactg gtggtggccc attacaggca accagttctc ctcagggcat     1620

ggtgcaagct gttgttctgc caacagttgg tttggtgtct cccataagta tcaatttaag     1680

tgatattcag aatgtactta aagtggcggt agatggtaat gtaataaggc aagtgttgga     1740

gaataatcaa gccaatcttg catccaaaga acaagaaaca atcaatgctt cacccataca     1800

acaaggtggc cattctgtta tttcagccat cagtcttcct ttggttgatc aagatggaac     1860

aaccaaaatt atcatcaact acagtcttga gcagcctagc caacttcaag ttgttcctca     1920

aaatttaaaa aaagaaaatc cagtcgctac aaacagttgt aaaagtgaaa agttaccaga     1980

agatcttact gttaagtctg agaaggacaa aagctttgaa gggggggtga atgatagcac     2040

ttgtcttctg tgtgatgatt gtccaggaga tattaatgca cttccagaat taaagcacta     2100

tgacctaaag cagcctactc agcctcctcc actccctgca gcagaagctg agaagcctga     2160

gtcctctgtt tcatcagcta ctggagatgg caatttgtct cctagtcagc cacctttaaa     2220

gaacctcttg tctctcctaa aagcatatta tgctttgaat gcacaaccaa gtgcagaaga     2280

gctctcaaaa attgctgatt cagtaaacct accactggat gtagtaaaaa agtggtttga     2340

aaagatgcaa gctggacaga tttcagtgca gtcttctgaa ccatcttctc ctgaaccagg     2400

caaagtaaat atccctgcca agaacaatga tcagcctcaa tctgcaaatg caaatgaacc     2460

ccaggacagc acagtaaatc tacaaagtcc tttgaagatg actaactccc cagttttacc     2520

agtgggatca accaccaatg gttccagaag tagtacacca tccccatcac ctctaaacct     2580

ttcctcatcc agaaatacac agggttactt gtacacagct gagggtgcac aagaagagcc     2640

acaagtagaa cctcttgatc tttcactacc aaagcaacag ggagaattat tagaaaggtc     2700

aactatcact agtgtttacc agaacagtgt ttattctgtc caggaagaac ccttgaactt     2760

gtcttgcgca aaaaaggagc cacaaaagga cagttgtgtt acagactcag aaccagttgt     2820

aaatgtaatc ccaccaagtg ccaaccccat aaatatcgct atacctacag tcactgccca     2880

gttacccaca atcgtggcca ttgctgacca gaacagtgtt ccatgcttaa gagcgctagc     2940

tgccaataag caaacgattc tgattcccca ggtggcatac acctactcaa ctacggtcag     3000

ccctgcagtc caagaaccac ccttgaaagt gatccagcca aatggaaatc aggatgaaag     3060

acaagatact agctcagaag gagtatcaaa tgtagaggat cagaatgact ctgattctac     3120

accgcccaaa aagaaaatgc ggaagacaga aaatggaatg tatgcttgtg atttgtgtga     3180

caagatattc caaaagagta gttcattatt gagacataaa tatgaacaca caggtaaaag     3240

acctcatgag tgtggaatct gtaaaaaggc atttaaacac aaacatcatt tgattgaaca     3300

catgcgatta cattctggag aaaagcccta tcaatgtgac aaatgtggaa agcgcttctc     3360

acactctggg tcttattctc aacacatgaa tcatcgctac tcctactgta agagagaagc     3420

ggaagaacgt gacagcacag agcaggaaga ggcagggcct gaaatcctct cgaatgagca     3480

cgtgggtgcc agggcgtctc cctcacaggg cgactcggac gagagagaga gtttgacaag     3540

ggaagaggat gaagacagtg aaaaagagga agaggaggag gataaagaga tggaagaatt     3600

gcaggaagaa aaagaatgtg aaaaaccaca aggggatgag gaagaggagg aggaggagga     3660

agaagtggaa gaagaagagg tagaagaggc agagaatgag ggagaagaag caaaaactga     3720

aggtctgatg aaggatgaca gggctgaaag tcaagcaagc agcttaggac aaaaagtagg     3780

cgagagtagt gagcaagtgt ctgaagaaaa gacaaatgaa gcctaatcgt ttttctagaa     3840

ggaaaataaa ttctaattga taatgaattt cgttcaatat tatccttgct tttcatggaa     3900

acacagtaac ctgtatgctg tgattcctgt tcactactgt gtaaagtaaa aactaaaaaa     3960

atacaaaata caaaacacac acacacacac acacacacac acacacacac acacaaaata     4020

aatccgggtg tgcctgaacc tcagacctag taatttttca tgcagttttc aaagttagga     4080

acaagtttgt aacatgcagc agattagaaa accttaatga ctcagagagc aacaatacaa     4140

gaggttaaag gaagctgatt aattagatat gcatctggca ttgttttatc ttatcagtat     4200

tatcactctt atgttggttt attcttaagc tgtacaattg ggagaaattt tataattttt     4260

tattggtaaa catatgctaa atccgcttca gtattttatt atgtttttta aaatgtgaga     4320

acttctgcac tacaaaattc ccttcacaga gaagtataat gtagttccaa cccgtgctaa     4380

ctacctttta taaattcagt ctagaaggta gtaatttcta atatttagat gtcttagtag     4440

agcgtattat catttaaagt gtattgttag ccttaagaaa gcagctgata gaagaactga     4500

agtttcttac tcacgtggtt taaaatggag ttcaaaagat tgccattgag ttctgattgc     4560

agggactaac aatgttaatc tgataaggac agcaaaatca tcagaatcag tgtttgtgat     4620

tgtgtttgaa tatgtggtaa catatgaagg atatgacatg aagctttgta tctcctttgg     4680

ccttaagcaa gacctgtgtg ctgtaagtgc catttctcag tattttcaag gctctaaccc     4740

gccttcatcc aatgtgtggc ctacaataac tagcatttgt tgatttgtct cttgtatcaa     4800

aattcccaaa taaaacttaa aaccactgac tctgtcagag aaactgaaac actgggacat     4860

ttcatccttc aattcctcgg tattgatttt atgttgattg attttcagaa tttctctaca     4920

gaaacgaaag ggaaattttc taatctgctt tatccatgta cttgcatttc agacatggac     4980

atgctattgt tatttggctc ataactgttt ccaaatgtta gttattatgg acccaattta     5040

ttaacaacat tagctgattt ttacctatca gtattatttt atttctttta gtttatagat     5100

ctgtgcaaca tttttgtact gtatgtcttc aaacctggca gtattaatac ccttcttact     5160

gacatatgta cttttagttt tagaaaactt ttatatttat gtgtcttatt tttatatttc     5220

tttatttatt acacagtgta gtgtataata ctgtagtttg tattaataca ataatatatt     5280

ttagtatgaa aatttggaaa gttgataaga tttaaagtag agatgcaatt ggttctcctg     5340

cattgagatt tgatttaaca gtgttatgtt aacatttata cttgccttgg actgtagaac     5400

agaacttaaa tgggaatgta ttagttttac aactacaatc aagtcatttt acctttaccc     5460

agtttttaat ataaaactta aattttgaaa ttcactgtgt gactaatagc atgatgctct     5520

gcagttttat taagaaatca gcctaaccat acaactctca tttccttagt aagccaaatt     5580

aggattaact tctataaaca gtgttgggaa caatgtttaa cattttgtgc caatttgttc     5640

ctgtattcat gtatgtaagt tacagatctg actcttcatt tttaagttcc ttgttacatc     5700

atggtcattt tctagttttt taccagactc ccatctcaca ataaaatgca tcaacaagcc     5760

tgaactgctg tcattctttt catcattatc agtattttct ttggaaaact gtgaaatggg     5820

gtacattgtc atcctgcatt tgattcatct tgagctgaat ttgggtaaca ctaaatgttt     5880

tagacattct ccactaaatt atggattttc ttgtggctaa atgtttctgg agaggtcaga     5940

gttgacaaaa cctcttcaca ggttgctcct tcttcctgaa atccttaatc ctccgcattt     6000

catgcttcag gtcatttcag ggaagcctgg gtttagatgc ctttctgact ctcagctcct     6060

gcacttctgt catcatacct ctgatactat tatttatatt ccttccccac taggaacagg     6120

aaccacattt gtcatagtca ctctcacatt cctcactgcc taacagggtg cctggcataa     6180

gttgggacaa cagatatttg ttgaataaaa atataatttg catgtttatg gagctcagct     6240

atgttctcac tttttttgct tctaattcca gaatatatgt taaatgatct aataatttga     6300

ttattttctt ataagtctta ttaaacacta gtcataatag acacaataaa ttatgccttc     6360

tttttc                                                                6366


<210> 50
<211> 906
<212> PRT
<213> Homo sapiens

<400> 50
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 51
<211> 5972
<212> DNA
<213> Homo sapiens

<400> 51
agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg       60

ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc      120

tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg      180

cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac      240

aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg      300

gagtgtcgta aaccaggaaa ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat      360

gaagcaggat gtacagtaaa agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac      420

catgatccta atgttgaaga gtttctacaa caacaagaca ctgctgtcat ttttcctgag      480

gcacctgaag aggaccagag gcagggcaca ccagaagcca gtggtcatga tgaaaatgga      540

acaccagatg cattttcaca attactcacc tgtccatatt gtgatagagg ctataaacgc      600

tttacctctc tgaaagaaca cattaaatat cgtcatgaaa agaatgaaga taactttagt      660

tgctccctgt gcagttacac ctttgcatac agaacccaac ttgaacgtca catgacatca      720

cataaatcag gaagagatca aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa      780

tgcactgagt gtggaaaagc tttcaaatac aaacatcacc taaaagagca cttaagaatt      840

cacagtggag agaagccata tgaatgccca aactgcaaga aacgcttttc ccattctggc      900

tcctatagct cacacataag cagtaagaaa tgtatcagct tgatacctgt gaatgggcga      960

ccaagaacag gactcaagac atctcagtgt tcttcaccgt ctctttcagc atcaccaggc     1020

agtcccacac gaccacagat acggcaaaag atagagaata aaccccttca agaacaactt     1080

tctgttaacc aaattaaaac tgaacctgtg gattatgaat tcaaacccat agtggttgct     1140

tcaggaatca actgttcaac ccctttacaa aatggggttt tcactggtgg tggcccatta     1200

caggcaacca gttctcctca gggcatggtg caagctgttg ttctgccaac agttggtttg     1260

gtgtctccca taagtatcaa tttaagtgat attcagaatg tacttaaagt ggcggtagat     1320

ggtaatgtaa taaggcaagt gttggagaat aatcaagcca atcttgcatc caaagaacaa     1380

gaaacaatca atgcttcacc catacaacaa ggtggccatt ctgttatttc agccatcagt     1440

cttcctttgg ttgatcaaga tggaacaacc aaaattatca tcaactacag tcttgagcag     1500

cctagccaac ttcaagttgt tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac     1560

agttgtaaaa gtgaaaagtt accagaagat cttactgtta agtctgagaa ggacaaaagc     1620

tttgaagggg gggtgaatga tagcacttgt cttctgtgtg atgattgtcc aggagatatt     1680

aatgcacttc cagaattaaa gcactatgac ctaaagcagc ctactcagcc tcctccactc     1740

cctgcagcag aagctgagaa gcctgagtcc tctgtttcat cagctactgg agatggcaat     1800

ttgtctccta gtcagccacc tttaaagaac ctcttgtctc tcctaaaagc atattatgct     1860

ttgaatgcac aaccaagtgc agaagagctc tcaaaaattg ctgattcagt aaacctacca     1920

ctggatgtag taaaaaagtg gtttgaaaag atgcaagctg gacagatttc agtgcagtct     1980

tctgaaccat cttctcctga accaggcaaa gtaaatatcc ctgccaagaa caatgatcag     2040

cctcaatctg caaatgcaaa tgaaccccag gacagcacag taaatctaca aagtcctttg     2100

aagatgacta actccccagt tttaccagtg ggatcaacca ccaatggttc cagaagtagt     2160

acaccatccc catcacctct aaacctttcc tcatccagaa atacacaggg ttacttgtac     2220

acagctgagg gtgcacaaga agagccacaa gtagaacctc ttgatctttc actaccaaag     2280

caacagggag aattattaga aaggtcaact atcactagtg tttaccagaa cagtgtttat     2340

tctgtccagg aagaaccctt gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt     2400

tgtgttacag actcagaacc agttgtaaat gtaatcccac caagtgccaa ccccataaat     2460

atcgctatac ctacagtcac tgcccagtta cccacaatcg tggccattgc tgaccagaac     2520

agtgttccat gcttaagagc gctagctgcc aataagcaaa cgattctgat tccccaggtg     2580

gcatacacct actcaactac ggtcagccct gcagtccaag aaccaccctt gaaagtgatc     2640

cagccaaatg gaaatcagga tgaaagacaa gatactagct cagaaggagt atcaaatgta     2700

gaggatcaga atgactctga ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat     2760

ggaatgtatg cttgtgattt gtgtgacaag atattccaaa agagtagttc attattgaga     2820

cataaatatg aacacacagg taaaagacct catgagtgtg gaatctgtaa aaaggcattt     2880

aaacacaaac atcatttgat tgaacacatg cgattacatt ctggagaaaa gccctatcaa     2940

tgtgacaaat gtggaaagcg cttctcacac tctgggtctt attctcaaca catgaatcat     3000

cgctactcct actgtaagag agaagcggaa gaacgtgaca gcacagagca ggaagaggca     3060

gggcctgaaa tcctctcgaa tgagcacgtg ggtgccaggg cgtctccctc acagggcgac     3120

tcggacgaga gagagagttt gacaagggaa gaggatgaag acagtgaaaa agaggaagag     3180

gaggaggata aagagatgga agaattgcag gaagaaaaag aatgtgaaaa accacaaggg     3240

gatgaggaag aggaggagga ggaggaagaa gtggaagaag aagaggtaga agaggcagag     3300

aatgagggag aagaagcaaa aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa     3360

gcaagcagct taggacaaaa agtaggcgag agtagtgagc aagtgtctga agaaaagaca     3420

aatgaagcct aatcgttttt ctagaaggaa aataaattct aattgataat gaatttcgtt     3480

caatattatc cttgcttttc atggaaacac agtaacctgt atgctgtgat tcctgttcac     3540

tactgtgtaa agtaaaaact aaaaaaatac aaaatacaaa acacacacac acacacacac     3600

acacacacac acacacacac aaaataaatc cgggtgtgcc tgaacctcag acctagtaat     3660

ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct     3720

taatgactca gagagcaaca atacaagagg ttaaaggaag ctgattaatt agatatgcat     3780

ctggcattgt tttatcttat cagtattatc actcttatgt tggtttattc ttaagctgta     3840

caattgggag aaattttata attttttatt ggtaaacata tgctaaatcc gcttcagtat     3900

tttattatgt tttttaaaat gtgagaactt ctgcactaca aaattccctt cacagagaag     3960

tataatgtag ttccaacccg tgctaactac cttttataaa ttcagtctag aaggtagtaa     4020

tttctaatat ttagatgtct tagtagagcg tattatcatt taaagtgtat tgttagcctt     4080

aagaaagcag ctgatagaag aactgaagtt tcttactcac gtggtttaaa atggagttca     4140

aaagattgcc attgagttct gattgcaggg actaacaatg ttaatctgat aaggacagca     4200

aaatcatcag aatcagtgtt tgtgattgtg tttgaatatg tggtaacata tgaaggatat     4260

gacatgaagc tttgtatctc ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt     4320

tctcagtatt ttcaaggctc taacccgcct tcatccaatg tgtggcctac aataactagc     4380

atttgttgat ttgtctcttg tatcaaaatt cccaaataaa acttaaaacc actgactctg     4440

tcagagaaac tgaaacactg ggacatttca tccttcaatt cctcggtatt gattttatgt     4500

tgattgattt tcagaatttc tctacagaaa cgaaagggaa attttctaat ctgctttatc     4560

catgtacttg catttcagac atggacatgc tattgttatt tggctcataa ctgtttccaa     4620

atgttagtta ttatggaccc aatttattaa caacattagc tgatttttac ctatcagtat     4680

tattttattt cttttagttt atagatctgt gcaacatttt tgtactgtat gtcttcaaac     4740

ctggcagtat taataccctt cttactgaca tatgtacttt tagttttaga aaacttttat     4800

atttatgtgt cttattttta tatttcttta tttattacac agtgtagtgt ataatactgt     4860

agtttgtatt aatacaataa tatattttag tatgaaaatt tggaaagttg ataagattta     4920

aagtagagat gcaattggtt ctcctgcatt gagatttgat ttaacagtgt tatgttaaca     4980

tttatacttg ccttggactg tagaacagaa cttaaatggg aatgtattag ttttacaact     5040

acaatcaagt cattttacct ttacccagtt tttaatataa aacttaaatt ttgaaattca     5100

ctgtgtgact aatagcatga tgctctgcag ttttattaag aaatcagcct aaccatacaa     5160

ctctcatttc cttagtaagc caaattagga ttaacttcta taaacagtgt tgggaacaat     5220

gtttaacatt ttgtgccaat ttgttcctgt attcatgtat gtaagttaca gatctgactc     5280

ttcattttta agttccttgt tacatcatgg tcattttcta gttttttacc agactcccat     5340

ctcacaataa aatgcatcaa caagcctgaa ctgctgtcat tcttttcatc attatcagta     5400

ttttctttgg aaaactgtga aatggggtac attgtcatcc tgcatttgat tcatcttgag     5460

ctgaatttgg gtaacactaa atgttttaga cattctccac taaattatgg attttcttgt     5520

ggctaaatgt ttctggagag gtcagagttg acaaaacctc ttcacaggtt gctccttctt     5580

cctgaaatcc ttaatcctcc gcatttcatg cttcaggtca tttcagggaa gcctgggttt     5640

agatgccttt ctgactctca gctcctgcac ttctgtcatc atacctctga tactattatt     5700

tatattcctt ccccactagg aacaggaacc acatttgtca tagtcactct cacattcctc     5760

actgcctaac agggtgcctg gcataagttg ggacaacaga tatttgttga ataaaaatat     5820

aatttgcatg tttatggagc tcagctatgt tctcactttt tttgcttcta attccagaat     5880

atatgttaaa tgatctaata atttgattat tttcttataa gtcttattaa acactagtca     5940

taatagacac aataaattat gccttctttt tc                                   5972


<210> 52
<211> 906
<212> PRT
<213> Homo sapiens

<400> 52
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 53
<211> 6316
<212> DNA
<213> Homo sapiens

<400> 53
agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg       60

ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc      120

tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg      180

cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac      240

aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg      300

gagtgtcgta aaccaggaca accttaaact tccaccacaa gaggaatata aagaggtccc      360

tcctgcacca agaaagatct gcagatcttt ttcagtgttc ttggaggtgt ggggtgtgag      420

aacttgatca gtttgtgtca gccaccttgt tctctaaagt tacaaattat aatactgtgg      480

tagaaacaaa ttcagattca gatgatgaag acaaactgca tattgtggaa gaagaaagtg      540

ttacagatgc agctgactgt gaaggtgtac cagaggatga cctgccaaca gaccagacag      600

tgttaccagg gaggagcagt gaaagagaag ggaatgctaa gaactgctgg gaggatgaca      660

gaaaggaagg gcaagaaatc ctggggcctg aagctcaggc agatgaagca ggatgtacag      720

taaaagatga tgaatgcgag tcagatgcag aaaatgagca aaaccatgat cctaatgttg      780

aagagtttct acaacaacaa gacactgctg tcatttttcc tgaggcacct gaagaggacc      840

agaggcaggg cacaccagaa gccagtggtc atgatgaaaa tggaacacca gatgcatttt      900

cacaattact cacctgtcca tattgtgata gaggctataa acgctttacc tctctgaaag      960

aacacattaa atatcgtcat gaaaagaatg aagataactt tagttgctcc ctgtgcagtt     1020

acacctttgc atacagaacc caacttgaac gtcacatgac atcacataaa tcaggaagag     1080

atcaaagaca tgtgacgcag tctgggtgta atcgtaaatt caaatgcact gagtgtggaa     1140

aagctttcaa atacaaacat cacctaaaag agcacttaag aattcacagt ggagagaagc     1200

catatgaatg cccaaactgc aagaaacgct tttcccattc tggctcctat agctcacaca     1260

taagcagtaa gaaatgtatc agcttgatac ctgtgaatgg gcgaccaaga acaggactca     1320

agacatctca gtgttcttca ccgtctcttt cagcatcacc aggcagtccc acacgaccac     1380

agatacggca aaagatagag aataaacccc ttcaagaaca actttctgtt aaccaaatta     1440

aaactgaacc tgtggattat gaattcaaac ccatagtggt tgcttcagga atcaactgtt     1500

caaccccttt acaaaatggg gttttcactg gtggtggccc attacaggca accagttctc     1560

ctcagggcat ggtgcaagct gttgttctgc caacagttgg tttggtgtct cccataagta     1620

tcaatttaag tgatattcag aatgtactta aagtggcggt agatggtaat gtaataaggc     1680

aagtgttgga gaataatcaa gccaatcttg catccaaaga acaagaaaca atcaatgctt     1740

cacccataca acaaggtggc cattctgtta tttcagccat cagtcttcct ttggttgatc     1800

aagatggaac aaccaaaatt atcatcaact acagtcttga gcagcctagc caacttcaag     1860

ttgttcctca aaatttaaaa aaagaaaatc cagtcgctac aaacagttgt aaaagtgaaa     1920

agttaccaga agatcttact gttaagtctg agaaggacaa aagctttgaa gggggggtga     1980

atgatagcac ttgtcttctg tgtgatgatt gtccaggaga tattaatgca cttccagaat     2040

taaagcacta tgacctaaag cagcctactc agcctcctcc actccctgca gcagaagctg     2100

agaagcctga gtcctctgtt tcatcagcta ctggagatgg caatttgtct cctagtcagc     2160

cacctttaaa gaacctcttg tctctcctaa aagcatatta tgctttgaat gcacaaccaa     2220

gtgcagaaga gctctcaaaa attgctgatt cagtaaacct accactggat gtagtaaaaa     2280

agtggtttga aaagatgcaa gctggacaga tttcagtgca gtcttctgaa ccatcttctc     2340

ctgaaccagg caaagtaaat atccctgcca agaacaatga tcagcctcaa tctgcaaatg     2400

caaatgaacc ccaggacagc acagtaaatc tacaaagtcc tttgaagatg actaactccc     2460

cagttttacc agtgggatca accaccaatg gttccagaag tagtacacca tccccatcac     2520

ctctaaacct ttcctcatcc agaaatacac agggttactt gtacacagct gagggtgcac     2580

aagaagagcc acaagtagaa cctcttgatc tttcactacc aaagcaacag ggagaattat     2640

tagaaaggtc aactatcact agtgtttacc agaacagtgt ttattctgtc caggaagaac     2700

ccttgaactt gtcttgcgca aaaaaggagc cacaaaagga cagttgtgtt acagactcag     2760

aaccagttgt aaatgtaatc ccaccaagtg ccaaccccat aaatatcgct atacctacag     2820

tcactgccca gttacccaca atcgtggcca ttgctgacca gaacagtgtt ccatgcttaa     2880

gagcgctagc tgccaataag caaacgattc tgattcccca ggtggcatac acctactcaa     2940

ctacggtcag ccctgcagtc caagaaccac ccttgaaagt gatccagcca aatggaaatc     3000

aggatgaaag acaagatact agctcagaag gagtatcaaa tgtagaggat cagaatgact     3060

ctgattctac accgcccaaa aagaaaatgc ggaagacaga aaatggaatg tatgcttgtg     3120

atttgtgtga caagatattc caaaagagta gttcattatt gagacataaa tatgaacaca     3180

caggtaaaag acctcatgag tgtggaatct gtaaaaaggc atttaaacac aaacatcatt     3240

tgattgaaca catgcgatta cattctggag aaaagcccta tcaatgtgac aaatgtggaa     3300

agcgcttctc acactctggg tcttattctc aacacatgaa tcatcgctac tcctactgta     3360

agagagaagc ggaagaacgt gacagcacag agcaggaaga ggcagggcct gaaatcctct     3420

cgaatgagca cgtgggtgcc agggcgtctc cctcacaggg cgactcggac gagagagaga     3480

gtttgacaag ggaagaggat gaagacagtg aaaaagagga agaggaggag gataaagaga     3540

tggaagaatt gcaggaagaa aaagaatgtg aaaaaccaca aggggatgag gaagaggagg     3600

aggaggagga agaagtggaa gaagaagagg tagaagaggc agagaatgag ggagaagaag     3660

caaaaactga aggtctgatg aaggatgaca gggctgaaag tcaagcaagc agcttaggac     3720

aaaaagtagg cgagagtagt gagcaagtgt ctgaagaaaa gacaaatgaa gcctaatcgt     3780

ttttctagaa ggaaaataaa ttctaattga taatgaattt cgttcaatat tatccttgct     3840

tttcatggaa acacagtaac ctgtatgctg tgattcctgt tcactactgt gtaaagtaaa     3900

aactaaaaaa atacaaaata caaaacacac acacacacac acacacacac acacacacac     3960

acacaaaata aatccgggtg tgcctgaacc tcagacctag taatttttca tgcagttttc     4020

aaagttagga acaagtttgt aacatgcagc agattagaaa accttaatga ctcagagagc     4080

aacaatacaa gaggttaaag gaagctgatt aattagatat gcatctggca ttgttttatc     4140

ttatcagtat tatcactctt atgttggttt attcttaagc tgtacaattg ggagaaattt     4200

tataattttt tattggtaaa catatgctaa atccgcttca gtattttatt atgtttttta     4260

aaatgtgaga acttctgcac tacaaaattc ccttcacaga gaagtataat gtagttccaa     4320

cccgtgctaa ctacctttta taaattcagt ctagaaggta gtaatttcta atatttagat     4380

gtcttagtag agcgtattat catttaaagt gtattgttag ccttaagaaa gcagctgata     4440

gaagaactga agtttcttac tcacgtggtt taaaatggag ttcaaaagat tgccattgag     4500

ttctgattgc agggactaac aatgttaatc tgataaggac agcaaaatca tcagaatcag     4560

tgtttgtgat tgtgtttgaa tatgtggtaa catatgaagg atatgacatg aagctttgta     4620

tctcctttgg ccttaagcaa gacctgtgtg ctgtaagtgc catttctcag tattttcaag     4680

gctctaaccc gccttcatcc aatgtgtggc ctacaataac tagcatttgt tgatttgtct     4740

cttgtatcaa aattcccaaa taaaacttaa aaccactgac tctgtcagag aaactgaaac     4800

actgggacat ttcatccttc aattcctcgg tattgatttt atgttgattg attttcagaa     4860

tttctctaca gaaacgaaag ggaaattttc taatctgctt tatccatgta cttgcatttc     4920

agacatggac atgctattgt tatttggctc ataactgttt ccaaatgtta gttattatgg     4980

acccaattta ttaacaacat tagctgattt ttacctatca gtattatttt atttctttta     5040

gtttatagat ctgtgcaaca tttttgtact gtatgtcttc aaacctggca gtattaatac     5100

ccttcttact gacatatgta cttttagttt tagaaaactt ttatatttat gtgtcttatt     5160

tttatatttc tttatttatt acacagtgta gtgtataata ctgtagtttg tattaataca     5220

ataatatatt ttagtatgaa aatttggaaa gttgataaga tttaaagtag agatgcaatt     5280

ggttctcctg cattgagatt tgatttaaca gtgttatgtt aacatttata cttgccttgg     5340

actgtagaac agaacttaaa tgggaatgta ttagttttac aactacaatc aagtcatttt     5400

acctttaccc agtttttaat ataaaactta aattttgaaa ttcactgtgt gactaatagc     5460

atgatgctct gcagttttat taagaaatca gcctaaccat acaactctca tttccttagt     5520

aagccaaatt aggattaact tctataaaca gtgttgggaa caatgtttaa cattttgtgc     5580

caatttgttc ctgtattcat gtatgtaagt tacagatctg actcttcatt tttaagttcc     5640

ttgttacatc atggtcattt tctagttttt taccagactc ccatctcaca ataaaatgca     5700

tcaacaagcc tgaactgctg tcattctttt catcattatc agtattttct ttggaaaact     5760

gtgaaatggg gtacattgtc atcctgcatt tgattcatct tgagctgaat ttgggtaaca     5820

ctaaatgttt tagacattct ccactaaatt atggattttc ttgtggctaa atgtttctgg     5880

agaggtcaga gttgacaaaa cctcttcaca ggttgctcct tcttcctgaa atccttaatc     5940

ctccgcattt catgcttcag gtcatttcag ggaagcctgg gtttagatgc ctttctgact     6000

ctcagctcct gcacttctgt catcatacct ctgatactat tatttatatt ccttccccac     6060

taggaacagg aaccacattt gtcatagtca ctctcacatt cctcactgcc taacagggtg     6120

cctggcataa gttgggacaa cagatatttg ttgaataaaa atataatttg catgtttatg     6180

gagctcagct atgttctcac tttttttgct tctaattcca gaatatatgt taaatgatct     6240

aataatttga ttattttctt ataagtctta ttaaacacta gtcataatag acacaataaa     6300

ttatgccttc tttttc                                                     6316


<210> 54
<211> 906
<212> PRT
<213> Homo sapiens

<400> 54
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 55
<211> 6554
<212> DNA
<213> Homo sapiens

<400> 55
agatccctcc ctgccccggg cagccgcggc gggtgtggcc agcgcggagg caggacgccg       60

ccgagcctcc aactttacct ttccaactcc gacagcccgt cgcctttctg accgcgtccc      120

tacggtttcc cggcatccgc ctccctctcc ccaccacacc tgaggaaaac ttttccctcg      180

cccctcaatt caaattcagc agtgcccacg gttgccgcaa accgcccggt ccctagcaac      240

aaggttccgg ccgtagagcg agagcctcta ggtgtaagga aggtgatgtc gtaaagccgg      300

gagtgtcgta aaccagtttt cagtttaaat tctcaactgg caattggccg aaaactccca      360

tctgaagaca tgatcatcca aatgtcattt tgtgatttgg ctactgtctg cttgacatag      420

gaaagcacta tcaagaaaga ctaatggagt gactatcaaa aggaagtcaa tggacaacct      480

taaacttcca ccacaagagg aatataaaga ggtccctcct gcaccaagaa agatctgcag      540

atctttttca gtgttcttgg aggtgtgggg tgtgagaact tgatcagttt gtgtcagcca      600

ccttgttctc taaagggaaa gcccctcaaa ccattttgta ttctgtatta cacttcagaa      660

agtgtggaag caaaggtcat ctaatcttta aaagttacaa attataatac tgtggtagaa      720

acaaattcag attcagatga tgaagacaaa ctgcatattg tggaagaaga aagtgttaca      780

gatgcagctg actgtgaagg tgtaccagag gatgacctgc caacagacca gacagtgtta      840

ccagggagga gcagtgaaag agaagggaat gctaagaact gctgggagga tgacacagga      900

aaggaagggc aagaaatcct ggggcctgaa gctcaggcag atgaagcagg atgtacagta      960

aaagatgatg aatgcgagtc agatgcagaa aatgagcaaa accatgatcc taatgttgaa     1020

gagtttctac aacaacaaga cactgctgtc atttttcctg aggcacctga agaggaccag     1080

aggcagggca caccagaagc cagtggtcat gatgaaaatg gaacaccaga tgcattttca     1140

caattactca cctgtccata ttgtgataga ggctataaac gctttacctc tctgaaagaa     1200

cacattaaat atcgtcatga aaagaatgaa gataacttta gttgctccct gtgcagttac     1260

acctttgcat acagaaccca acttgaacgt cacatgacat cacataaatc aggaagagat     1320

caaagacatg tgacgcagtc tgggtgtaat cgtaaattca aatgcactga gtgtggaaaa     1380

gctttcaaat acaaacatca cctaaaagag cacttaagaa ttcacagtgg agagaagcca     1440

tatgaatgcc caaactgcaa gaaacgcttt tcccattctg gctcctatag ctcacacata     1500

agcagtaaga aatgtatcag cttgatacct gtgaatgggc gaccaagaac aggactcaag     1560

acatctcagt gttcttcacc gtctctttca gcatcaccag gcagtcccac acgaccacag     1620

atacggcaaa agatagagaa taaacccctt caagaacaac tttctgttaa ccaaattaaa     1680

actgaacctg tggattatga attcaaaccc atagtggttg cttcaggaat caactgttca     1740

acccctttac aaaatggggt tttcactggt ggtggcccat tacaggcaac cagttctcct     1800

cagggcatgg tgcaagctgt tgttctgcca acagttggtt tggtgtctcc cataagtatc     1860

aatttaagtg atattcagaa tgtacttaaa gtggcggtag atggtaatgt aataaggcaa     1920

gtgttggaga ataatcaagc caatcttgca tccaaagaac aagaaacaat caatgcttca     1980

cccatacaac aaggtggcca ttctgttatt tcagccatca gtcttccttt ggttgatcaa     2040

gatggaacaa ccaaaattat catcaactac agtcttgagc agcctagcca acttcaagtt     2100

gttcctcaaa atttaaaaaa agaaaatcca gtcgctacaa acagttgtaa aagtgaaaag     2160

ttaccagaag atcttactgt taagtctgag aaggacaaaa gctttgaagg gggggtgaat     2220

gatagcactt gtcttctgtg tgatgattgt ccaggagata ttaatgcact tccagaatta     2280

aagcactatg acctaaagca gcctactcag cctcctccac tccctgcagc agaagctgag     2340

aagcctgagt cctctgtttc atcagctact ggagatggca atttgtctcc tagtcagcca     2400

cctttaaaga acctcttgtc tctcctaaaa gcatattatg ctttgaatgc acaaccaagt     2460

gcagaagagc tctcaaaaat tgctgattca gtaaacctac cactggatgt agtaaaaaag     2520

tggtttgaaa agatgcaagc tggacagatt tcagtgcagt cttctgaacc atcttctcct     2580

gaaccaggca aagtaaatat ccctgccaag aacaatgatc agcctcaatc tgcaaatgca     2640

aatgaacccc aggacagcac agtaaatcta caaagtcctt tgaagatgac taactcccca     2700

gttttaccag tgggatcaac caccaatggt tccagaagta gtacaccatc cccatcacct     2760

ctaaaccttt cctcatccag aaatacacag ggttacttgt acacagctga gggtgcacaa     2820

gaagagccac aagtagaacc tcttgatctt tcactaccaa agcaacaggg agaattatta     2880

gaaaggtcaa ctatcactag tgtttaccag aacagtgttt attctgtcca ggaagaaccc     2940

ttgaacttgt cttgcgcaaa aaaggagcca caaaaggaca gttgtgttac agactcagaa     3000

ccagttgtaa atgtaatccc accaagtgcc aaccccataa atatcgctat acctacagtc     3060

actgcccagt tacccacaat cgtggccatt gctgaccaga acagtgttcc atgcttaaga     3120

gcgctagctg ccaataagca aacgattctg attccccagg tggcatacac ctactcaact     3180

acggtcagcc ctgcagtcca agaaccaccc ttgaaagtga tccagccaaa tggaaatcag     3240

gatgaaagac aagatactag ctcagaagga gtatcaaatg tagaggatca gaatgactct     3300

gattctacac cgcccaaaaa gaaaatgcgg aagacagaaa atggaatgta tgcttgtgat     3360

ttgtgtgaca agatattcca aaagagtagt tcattattga gacataaata tgaacacaca     3420

ggtaaaagac ctcatgagtg tggaatctgt aaaaaggcat ttaaacacaa acatcatttg     3480

attgaacaca tgcgattaca ttctggagaa aagccctatc aatgtgacaa atgtggaaag     3540

cgcttctcac actctgggtc ttattctcaa cacatgaatc atcgctactc ctactgtaag     3600

agagaagcgg aagaacgtga cagcacagag caggaagagg cagggcctga aatcctctcg     3660

aatgagcacg tgggtgccag ggcgtctccc tcacagggcg actcggacga gagagagagt     3720

ttgacaaggg aagaggatga agacagtgaa aaagaggaag aggaggagga taaagagatg     3780

gaagaattgc aggaagaaaa agaatgtgaa aaaccacaag gggatgagga agaggaggag     3840

gaggaggaag aagtggaaga agaagaggta gaagaggcag agaatgaggg agaagaagca     3900

aaaactgaag gtctgatgaa ggatgacagg gctgaaagtc aagcaagcag cttaggacaa     3960

aaagtaggcg agagtagtga gcaagtgtct gaagaaaaga caaatgaagc ctaatcgttt     4020

ttctagaagg aaaataaatt ctaattgata atgaatttcg ttcaatatta tccttgcttt     4080

tcatggaaac acagtaacct gtatgctgtg attcctgttc actactgtgt aaagtaaaaa     4140

ctaaaaaaat acaaaataca aaacacacac acacacacac acacacacac acacacacac     4200

acaaaataaa tccgggtgtg cctgaacctc agacctagta atttttcatg cagttttcaa     4260

agttaggaac aagtttgtaa catgcagcag attagaaaac cttaatgact cagagagcaa     4320

caatacaaga ggttaaagga agctgattaa ttagatatgc atctggcatt gttttatctt     4380

atcagtatta tcactcttat gttggtttat tcttaagctg tacaattggg agaaatttta     4440

taatttttta ttggtaaaca tatgctaaat ccgcttcagt attttattat gttttttaaa     4500

atgtgagaac ttctgcacta caaaattccc ttcacagaga agtataatgt agttccaacc     4560

cgtgctaact accttttata aattcagtct agaaggtagt aatttctaat atttagatgt     4620

cttagtagag cgtattatca tttaaagtgt attgttagcc ttaagaaagc agctgataga     4680

agaactgaag tttcttactc acgtggttta aaatggagtt caaaagattg ccattgagtt     4740

ctgattgcag ggactaacaa tgttaatctg ataaggacag caaaatcatc agaatcagtg     4800

tttgtgattg tgtttgaata tgtggtaaca tatgaaggat atgacatgaa gctttgtatc     4860

tcctttggcc ttaagcaaga cctgtgtgct gtaagtgcca tttctcagta ttttcaaggc     4920

tctaacccgc cttcatccaa tgtgtggcct acaataacta gcatttgttg atttgtctct     4980

tgtatcaaaa ttcccaaata aaacttaaaa ccactgactc tgtcagagaa actgaaacac     5040

tgggacattt catccttcaa ttcctcggta ttgattttat gttgattgat tttcagaatt     5100

tctctacaga aacgaaaggg aaattttcta atctgcttta tccatgtact tgcatttcag     5160

acatggacat gctattgtta tttggctcat aactgtttcc aaatgttagt tattatggac     5220

ccaatttatt aacaacatta gctgattttt acctatcagt attattttat ttcttttagt     5280

ttatagatct gtgcaacatt tttgtactgt atgtcttcaa acctggcagt attaataccc     5340

ttcttactga catatgtact tttagtttta gaaaactttt atatttatgt gtcttatttt     5400

tatatttctt tatttattac acagtgtagt gtataatact gtagtttgta ttaatacaat     5460

aatatatttt agtatgaaaa tttggaaagt tgataagatt taaagtagag atgcaattgg     5520

ttctcctgca ttgagatttg atttaacagt gttatgttaa catttatact tgccttggac     5580

tgtagaacag aacttaaatg ggaatgtatt agttttacaa ctacaatcaa gtcattttac     5640

ctttacccag tttttaatat aaaacttaaa ttttgaaatt cactgtgtga ctaatagcat     5700

gatgctctgc agttttatta agaaatcagc ctaaccatac aactctcatt tccttagtaa     5760

gccaaattag gattaacttc tataaacagt gttgggaaca atgtttaaca ttttgtgcca     5820

atttgttcct gtattcatgt atgtaagtta cagatctgac tcttcatttt taagttcctt     5880

gttacatcat ggtcattttc tagtttttta ccagactccc atctcacaat aaaatgcatc     5940

aacaagcctg aactgctgtc attcttttca tcattatcag tattttcttt ggaaaactgt     6000

gaaatggggt acattgtcat cctgcatttg attcatcttg agctgaattt gggtaacact     6060

aaatgtttta gacattctcc actaaattat ggattttctt gtggctaaat gtttctggag     6120

aggtcagagt tgacaaaacc tcttcacagg ttgctccttc ttcctgaaat ccttaatcct     6180

ccgcatttca tgcttcaggt catttcaggg aagcctgggt ttagatgcct ttctgactct     6240

cagctcctgc acttctgtca tcatacctct gatactatta tttatattcc ttccccacta     6300

ggaacaggaa ccacatttgt catagtcact ctcacattcc tcactgccta acagggtgcc     6360

tggcataagt tgggacaaca gatatttgtt gaataaaaat ataatttgca tgtttatgga     6420

gctcagctat gttctcactt tttttgcttc taattccaga atatatgtta aatgatctaa     6480

taatttgatt attttcttat aagtcttatt aaacactagt cataatagac acaataaatt     6540

atgccttctt tttc                                                       6554


<210> 56
<211> 906
<212> PRT
<213> Homo sapiens

<400> 56
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 57
<211> 6077
<212> DNA
<213> Homo sapiens

<400> 57
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacggac aaccttaaac ttccaccaca agaggaatat aaagaggtcc      120

ctcctgcacc aagaaagatc tgcagatctt tttcagtgtt cttggaggtg tggggtgtga      180

gaacttgatc agtttgtgtc agccaccttg ttctctaaag ttacaaatta taatactgtg      240

gtagaaacaa attcagattc agatgatgaa gacaaactgc atattgtgga agaagaaagt      300

gttacagatg cagctgactg tgaaggtgta ccagaggatg acctgccaac agaccagaca      360

gtgttaccag ggaggagcag tgaaagagaa gggaatgcta agaactgctg ggaggatgac      420

agaaaggaag ggcaagaaat cctggggcct gaagctcagg cagatgaagc aggatgtaca      480

gtaaaagatg atgaatgcga gtcagatgca gaaaatgagc aaaaccatga tcctaatgtt      540

gaagagtttc tacaacaaca agacactgct gtcatttttc ctgaggcacc tgaagaggac      600

cagaggcagg gcacaccaga agccagtggt catgatgaaa atggaacacc agatgcattt      660

tcacaattac tcacctgtcc atattgtgat agaggctata aacgctttac ctctctgaaa      720

gaacacatta aatatcgtca tgaaaagaat gaagataact ttagttgctc cctgtgcagt      780

tacacctttg catacagaac ccaacttgaa cgtcacatga catcacataa atcaggaaga      840

gatcaaagac atgtgacgca gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga      900

aaagctttca aatacaaaca tcacctaaaa gagcacttaa gaattcacag tggagagaag      960

ccatatgaat gcccaaactg caagaaacgc ttttcccatt ctggctccta tagctcacac     1020

ataagcagta agaaatgtat cagcttgata cctgtgaatg ggcgaccaag aacaggactc     1080

aagacatctc agtgttcttc accgtctctt tcagcatcac caggcagtcc cacacgacca     1140

cagatacggc aaaagataga gaataaaccc cttcaagaac aactttctgt taaccaaatt     1200

aaaactgaac ctgtggatta tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt     1260

tcaacccctt tacaaaatgg ggttttcact ggtggtggcc cattacaggc aaccagttct     1320

cctcagggca tggtgcaagc tgttgttctg ccaacagttg gtttggtgtc tcccataagt     1380

atcaatttaa gtgatattca gaatgtactt aaagtggcgg tagatggtaa tgtaataagg     1440

caagtgttgg agaataatca agccaatctt gcatccaaag aacaagaaac aatcaatgct     1500

tcacccatac aacaaggtgg ccattctgtt atttcagcca tcagtcttcc tttggttgat     1560

caagatggaa caaccaaaat tatcatcaac tacagtcttg agcagcctag ccaacttcaa     1620

gttgttcctc aaaatttaaa aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa     1680

aagttaccag aagatcttac tgttaagtct gagaaggaca aaagctttga agggggggtg     1740

aatgatagca cttgtcttct gtgtgatgat tgtccaggag atattaatgc acttccagaa     1800

ttaaagcact atgacctaaa gcagcctact cagcctcctc cactccctgc agcagaagct     1860

gagaagcctg agtcctctgt ttcatcagct actggagatg gcaatttgtc tcctagtcag     1920

ccacctttaa agaacctctt gtctctccta aaagcatatt atgctttgaa tgcacaacca     1980

agtgcagaag agctctcaaa aattgctgat tcagtaaacc taccactgga tgtagtaaaa     2040

aagtggtttg aaaagatgca agctggacag atttcagtgc agtcttctga accatcttct     2100

cctgaaccag gcaaagtaaa tatccctgcc aagaacaatg atcagcctca atctgcaaat     2160

gcaaatgaac cccaggacag cacagtaaat ctacaaagtc ctttgaagat gactaactcc     2220

ccagttttac cagtgggatc aaccaccaat ggttccagaa gtagtacacc atccccatca     2280

cctctaaacc tttcctcatc cagaaataca cagggttact tgtacacagc tgagggtgca     2340

caagaagagc cacaagtaga acctcttgat ctttcactac caaagcaaca gggagaatta     2400

ttagaaaggt caactatcac tagtgtttac cagaacagtg tttattctgt ccaggaagaa     2460

cccttgaact tgtcttgcgc aaaaaaggag ccacaaaagg acagttgtgt tacagactca     2520

gaaccagttg taaatgtaat cccaccaagt gccaacccca taaatatcgc tatacctaca     2580

gtcactgccc agttacccac aatcgtggcc attgctgacc agaacagtgt tccatgctta     2640

agagcgctag ctgccaataa gcaaacgatt ctgattcccc aggtggcata cacctactca     2700

actacggtca gccctgcagt ccaagaacca cccttgaaag tgatccagcc aaatggaaat     2760

caggatgaaa gacaagatac tagctcagaa ggagtatcaa atgtagagga tcagaatgac     2820

tctgattcta caccgcccaa aaagaaaatg cggaagacag aaaatggaat gtatgcttgt     2880

gatttgtgtg acaagatatt ccaaaagagt agttcattat tgagacataa atatgaacac     2940

acaggtaaaa gacctcatga gtgtggaatc tgtaaaaagg catttaaaca caaacatcat     3000

ttgattgaac acatgcgatt acattctgga gaaaagccct atcaatgtga caaatgtgga     3060

aagcgcttct cacactctgg gtcttattct caacacatga atcatcgcta ctcctactgt     3120

aagagagaag cggaagaacg tgacagcaca gagcaggaag aggcagggcc tgaaatcctc     3180

tcgaatgagc acgtgggtgc cagggcgtct ccctcacagg gcgactcgga cgagagagag     3240

agtttgacaa gggaagagga tgaagacagt gaaaaagagg aagaggagga ggataaagag     3300

atggaagaat tgcaggaaga aaaagaatgt gaaaaaccac aaggggatga ggaagaggag     3360

gaggaggagg aagaagtgga agaagaagag gtagaagagg cagagaatga gggagaagaa     3420

gcaaaaactg aaggtctgat gaaggatgac agggctgaaa gtcaagcaag cagcttagga     3480

caaaaagtag gcgagagtag tgagcaagtg tctgaagaaa agacaaatga agcctaatcg     3540

tttttctaga aggaaaataa attctaattg ataatgaatt tcgttcaata ttatccttgc     3600

ttttcatgga aacacagtaa cctgtatgct gtgattcctg ttcactactg tgtaaagtaa     3660

aaactaaaaa aatacaaaat acaaaacaca cacacacaca cacacacaca cacacacaca     3720

cacacaaaat aaatccgggt gtgcctgaac ctcagaccta gtaatttttc atgcagtttt     3780

caaagttagg aacaagtttg taacatgcag cagattagaa aaccttaatg actcagagag     3840

caacaataca agaggttaaa ggaagctgat taattagata tgcatctggc attgttttat     3900

cttatcagta ttatcactct tatgttggtt tattcttaag ctgtacaatt gggagaaatt     3960

ttataatttt ttattggtaa acatatgcta aatccgcttc agtattttat tatgtttttt     4020

aaaatgtgag aacttctgca ctacaaaatt cccttcacag agaagtataa tgtagttcca     4080

acccgtgcta actacctttt ataaattcag tctagaaggt agtaatttct aatatttaga     4140

tgtcttagta gagcgtatta tcatttaaag tgtattgtta gccttaagaa agcagctgat     4200

agaagaactg aagtttctta ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga     4260

gttctgattg cagggactaa caatgttaat ctgataagga cagcaaaatc atcagaatca     4320

gtgtttgtga ttgtgtttga atatgtggta acatatgaag gatatgacat gaagctttgt     4380

atctcctttg gccttaagca agacctgtgt gctgtaagtg ccatttctca gtattttcaa     4440

ggctctaacc cgccttcatc caatgtgtgg cctacaataa ctagcatttg ttgatttgtc     4500

tcttgtatca aaattcccaa ataaaactta aaaccactga ctctgtcaga gaaactgaaa     4560

cactgggaca tttcatcctt caattcctcg gtattgattt tatgttgatt gattttcaga     4620

atttctctac agaaacgaaa gggaaatttt ctaatctgct ttatccatgt acttgcattt     4680

cagacatgga catgctattg ttatttggct cataactgtt tccaaatgtt agttattatg     4740

gacccaattt attaacaaca ttagctgatt tttacctatc agtattattt tatttctttt     4800

agtttataga tctgtgcaac atttttgtac tgtatgtctt caaacctggc agtattaata     4860

cccttcttac tgacatatgt acttttagtt ttagaaaact tttatattta tgtgtcttat     4920

ttttatattt ctttatttat tacacagtgt agtgtataat actgtagttt gtattaatac     4980

aataatatat tttagtatga aaatttggaa agttgataag atttaaagta gagatgcaat     5040

tggttctcct gcattgagat ttgatttaac agtgttatgt taacatttat acttgccttg     5100

gactgtagaa cagaacttaa atgggaatgt attagtttta caactacaat caagtcattt     5160

tacctttacc cagtttttaa tataaaactt aaattttgaa attcactgtg tgactaatag     5220

catgatgctc tgcagtttta ttaagaaatc agcctaacca tacaactctc atttccttag     5280

taagccaaat taggattaac ttctataaac agtgttggga acaatgttta acattttgtg     5340

ccaatttgtt cctgtattca tgtatgtaag ttacagatct gactcttcat ttttaagttc     5400

cttgttacat catggtcatt ttctagtttt ttaccagact cccatctcac aataaaatgc     5460

atcaacaagc ctgaactgct gtcattcttt tcatcattat cagtattttc tttggaaaac     5520

tgtgaaatgg ggtacattgt catcctgcat ttgattcatc ttgagctgaa tttgggtaac     5580

actaaatgtt ttagacattc tccactaaat tatggatttt cttgtggcta aatgtttctg     5640

gagaggtcag agttgacaaa acctcttcac aggttgctcc ttcttcctga aatccttaat     5700

cctccgcatt tcatgcttca ggtcatttca gggaagcctg ggtttagatg cctttctgac     5760

tctcagctcc tgcacttctg tcatcatacc tctgatacta ttatttatat tccttcccca     5820

ctaggaacag gaaccacatt tgtcatagtc actctcacat tcctcactgc ctaacagggt     5880

gcctggcata agttgggaca acagatattt gttgaataaa aatataattt gcatgtttat     5940

ggagctcagc tatgttctca ctttttttgc ttctaattcc agaatatatg ttaaatgatc     6000

taataatttg attattttct tataagtctt attaaacact agtcataata gacacaataa     6060

attatgcctt ctttttc                                                    6077


<210> 58
<211> 906
<212> PRT
<213> Homo sapiens

<400> 58
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 59
<211> 6017
<212> DNA
<213> Homo sapiens

<400> 59
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacggac aaccttaaac ttccaccaca agaggaatat aaagaggtcc      120

ctcctgcacc aagaaagatc tgcagatctt tttcagtgtt cttggaggtg tggggtgtga      180

gaacttgatc agtttgtgtc agccaccttg ttctctaaag ttacaaatta taatactgtg      240

gtagaaacaa attcagattc agatgatgaa gacaaactgc atattgtgga agaagaaagt      300

gttacagatg cagctgactg tgaaggtgta ccagaggatg acctgccaac agaccagaca      360

gtgttaccag ggaggagcag tgaaagagaa gggaatgcta agaactgctg ggaggatgac      420

ataaaagatg atgaatgcga gtcagatgca gaaaatgagc aaaaccatga tcctaatgtt      480

gaagagtttc tacaacaaca agacactgct gtcatttttc ctgaggcacc tgaagaggac      540

cagaggcagg gcacaccaga agccagtggt catgatgaaa atggaacacc agatgcattt      600

tcacaattac tcacctgtcc atattgtgat agaggctata aacgctttac ctctctgaaa      660

gaacacatta aatatcgtca tgaaaagaat gaagataact ttagttgctc cctgtgcagt      720

tacacctttg catacagaac ccaacttgaa cgtcacatga catcacataa atcaggaaga      780

gatcaaagac atgtgacgca gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga      840

aaagctttca aatacaaaca tcacctaaaa gagcacttaa gaattcacag tggagagaag      900

ccatatgaat gcccaaactg caagaaacgc ttttcccatt ctggctccta tagctcacac      960

ataagcagta agaaatgtat cagcttgata cctgtgaatg ggcgaccaag aacaggactc     1020

aagacatctc agtgttcttc accgtctctt tcagcatcac caggcagtcc cacacgacca     1080

cagatacggc aaaagataga gaataaaccc cttcaagaac aactttctgt taaccaaatt     1140

aaaactgaac ctgtggatta tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt     1200

tcaacccctt tacaaaatgg ggttttcact ggtggtggcc cattacaggc aaccagttct     1260

cctcagggca tggtgcaagc tgttgttctg ccaacagttg gtttggtgtc tcccataagt     1320

atcaatttaa gtgatattca gaatgtactt aaagtggcgg tagatggtaa tgtaataagg     1380

caagtgttgg agaataatca agccaatctt gcatccaaag aacaagaaac aatcaatgct     1440

tcacccatac aacaaggtgg ccattctgtt atttcagcca tcagtcttcc tttggttgat     1500

caagatggaa caaccaaaat tatcatcaac tacagtcttg agcagcctag ccaacttcaa     1560

gttgttcctc aaaatttaaa aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa     1620

aagttaccag aagatcttac tgttaagtct gagaaggaca aaagctttga agggggggtg     1680

aatgatagca cttgtcttct gtgtgatgat tgtccaggag atattaatgc acttccagaa     1740

ttaaagcact atgacctaaa gcagcctact cagcctcctc cactccctgc agcagaagct     1800

gagaagcctg agtcctctgt ttcatcagct actggagatg gcaatttgtc tcctagtcag     1860

ccacctttaa agaacctctt gtctctccta aaagcatatt atgctttgaa tgcacaacca     1920

agtgcagaag agctctcaaa aattgctgat tcagtaaacc taccactgga tgtagtaaaa     1980

aagtggtttg aaaagatgca agctggacag atttcagtgc agtcttctga accatcttct     2040

cctgaaccag gcaaagtaaa tatccctgcc aagaacaatg atcagcctca atctgcaaat     2100

gcaaatgaac cccaggacag cacagtaaat ctacaaagtc ctttgaagat gactaactcc     2160

ccagttttac cagtgggatc aaccaccaat ggttccagaa gtagtacacc atccccatca     2220

cctctaaacc tttcctcatc cagaaataca cagggttact tgtacacagc tgagggtgca     2280

caagaagagc cacaagtaga acctcttgat ctttcactac caaagcaaca gggagaatta     2340

ttagaaaggt caactatcac tagtgtttac cagaacagtg tttattctgt ccaggaagaa     2400

cccttgaact tgtcttgcgc aaaaaaggag ccacaaaagg acagttgtgt tacagactca     2460

gaaccagttg taaatgtaat cccaccaagt gccaacccca taaatatcgc tatacctaca     2520

gtcactgccc agttacccac aatcgtggcc attgctgacc agaacagtgt tccatgctta     2580

agagcgctag ctgccaataa gcaaacgatt ctgattcccc aggtggcata cacctactca     2640

actacggtca gccctgcagt ccaagaacca cccttgaaag tgatccagcc aaatggaaat     2700

caggatgaaa gacaagatac tagctcagaa ggagtatcaa atgtagagga tcagaatgac     2760

tctgattcta caccgcccaa aaagaaaatg cggaagacag aaaatggaat gtatgcttgt     2820

gatttgtgtg acaagatatt ccaaaagagt agttcattat tgagacataa atatgaacac     2880

acaggtaaaa gacctcatga gtgtggaatc tgtaaaaagg catttaaaca caaacatcat     2940

ttgattgaac acatgcgatt acattctgga gaaaagccct atcaatgtga caaatgtgga     3000

aagcgcttct cacactctgg gtcttattct caacacatga atcatcgcta ctcctactgt     3060

aagagagaag cggaagaacg tgacagcaca gagcaggaag aggcagggcc tgaaatcctc     3120

tcgaatgagc acgtgggtgc cagggcgtct ccctcacagg gcgactcgga cgagagagag     3180

agtttgacaa gggaagagga tgaagacagt gaaaaagagg aagaggagga ggataaagag     3240

atggaagaat tgcaggaaga aaaagaatgt gaaaaaccac aaggggatga ggaagaggag     3300

gaggaggagg aagaagtgga agaagaagag gtagaagagg cagagaatga gggagaagaa     3360

gcaaaaactg aaggtctgat gaaggatgac agggctgaaa gtcaagcaag cagcttagga     3420

caaaaagtag gcgagagtag tgagcaagtg tctgaagaaa agacaaatga agcctaatcg     3480

tttttctaga aggaaaataa attctaattg ataatgaatt tcgttcaata ttatccttgc     3540

ttttcatgga aacacagtaa cctgtatgct gtgattcctg ttcactactg tgtaaagtaa     3600

aaactaaaaa aatacaaaat acaaaacaca cacacacaca cacacacaca cacacacaca     3660

cacacaaaat aaatccgggt gtgcctgaac ctcagaccta gtaatttttc atgcagtttt     3720

caaagttagg aacaagtttg taacatgcag cagattagaa aaccttaatg actcagagag     3780

caacaataca agaggttaaa ggaagctgat taattagata tgcatctggc attgttttat     3840

cttatcagta ttatcactct tatgttggtt tattcttaag ctgtacaatt gggagaaatt     3900

ttataatttt ttattggtaa acatatgcta aatccgcttc agtattttat tatgtttttt     3960

aaaatgtgag aacttctgca ctacaaaatt cccttcacag agaagtataa tgtagttcca     4020

acccgtgcta actacctttt ataaattcag tctagaaggt agtaatttct aatatttaga     4080

tgtcttagta gagcgtatta tcatttaaag tgtattgtta gccttaagaa agcagctgat     4140

agaagaactg aagtttctta ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga     4200

gttctgattg cagggactaa caatgttaat ctgataagga cagcaaaatc atcagaatca     4260

gtgtttgtga ttgtgtttga atatgtggta acatatgaag gatatgacat gaagctttgt     4320

atctcctttg gccttaagca agacctgtgt gctgtaagtg ccatttctca gtattttcaa     4380

ggctctaacc cgccttcatc caatgtgtgg cctacaataa ctagcatttg ttgatttgtc     4440

tcttgtatca aaattcccaa ataaaactta aaaccactga ctctgtcaga gaaactgaaa     4500

cactgggaca tttcatcctt caattcctcg gtattgattt tatgttgatt gattttcaga     4560

atttctctac agaaacgaaa gggaaatttt ctaatctgct ttatccatgt acttgcattt     4620

cagacatgga catgctattg ttatttggct cataactgtt tccaaatgtt agttattatg     4680

gacccaattt attaacaaca ttagctgatt tttacctatc agtattattt tatttctttt     4740

agtttataga tctgtgcaac atttttgtac tgtatgtctt caaacctggc agtattaata     4800

cccttcttac tgacatatgt acttttagtt ttagaaaact tttatattta tgtgtcttat     4860

ttttatattt ctttatttat tacacagtgt agtgtataat actgtagttt gtattaatac     4920

aataatatat tttagtatga aaatttggaa agttgataag atttaaagta gagatgcaat     4980

tggttctcct gcattgagat ttgatttaac agtgttatgt taacatttat acttgccttg     5040

gactgtagaa cagaacttaa atgggaatgt attagtttta caactacaat caagtcattt     5100

tacctttacc cagtttttaa tataaaactt aaattttgaa attcactgtg tgactaatag     5160

catgatgctc tgcagtttta ttaagaaatc agcctaacca tacaactctc atttccttag     5220

taagccaaat taggattaac ttctataaac agtgttggga acaatgttta acattttgtg     5280

ccaatttgtt cctgtattca tgtatgtaag ttacagatct gactcttcat ttttaagttc     5340

cttgttacat catggtcatt ttctagtttt ttaccagact cccatctcac aataaaatgc     5400

atcaacaagc ctgaactgct gtcattcttt tcatcattat cagtattttc tttggaaaac     5460

tgtgaaatgg ggtacattgt catcctgcat ttgattcatc ttgagctgaa tttgggtaac     5520

actaaatgtt ttagacattc tccactaaat tatggatttt cttgtggcta aatgtttctg     5580

gagaggtcag agttgacaaa acctcttcac aggttgctcc ttcttcctga aatccttaat     5640

cctccgcatt tcatgcttca ggtcatttca gggaagcctg ggtttagatg cctttctgac     5700

tctcagctcc tgcacttctg tcatcatacc tctgatacta ttatttatat tccttcccca     5760

ctaggaacag gaaccacatt tgtcatagtc actctcacat tcctcactgc ctaacagggt     5820

gcctggcata agttgggaca acagatattt gttgaataaa aatataattt gcatgtttat     5880

ggagctcagc tatgttctca ctttttttgc ttctaattcc agaatatatg ttaaatgatc     5940

taataatttg attattttct tataagtctt attaaacact agtcataata gacacaataa     6000

attatgcctt ctttttc                                                    6017


<210> 60
<211> 906
<212> PRT
<213> Homo sapiens

<400> 60
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 61
<211> 6080
<212> DNA
<213> Homo sapiens

<400> 61
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacggac aaccttaaac ttccaccaca agaggaatat aaagaggtcc      120

ctcctgcacc aagaaagatc tgcagatctt tttcagtgtt cttggaggtg tggggtgtga      180

gaacttgatc agtttgtgtc agccaccttg ttctctaaag ttacaaatta taatactgtg      240

gtagaaacaa attcagattc agatgatgaa gacaaactgc atattgtgga agaagaaagt      300

gttacagatg cagctgactg tgaaggtgta ccagaggatg acctgccaac agaccagaca      360

gtgttaccag ggaggagcag tgaaagagaa gggaatgcta agaactgctg ggaggatgac      420

acaggaaagg aagggcaaga aatcctgggg cctgaagctc aggcagatga agcaggatgt      480

acagtaaaag atgatgaatg cgagtcagat gcagaaaatg agcaaaacca tgatcctaat      540

gttgaagagt ttctacaaca acaagacact gctgtcattt ttcctgaggc acctgaagag      600

gaccagaggc agggcacacc agaagccagt ggtcatgatg aaaatggaac accagatgca      660

ttttcacaat tactcacctg tccatattgt gatagaggct ataaacgctt tacctctctg      720

aaagaacaca ttaaatatcg tcatgaaaag aatgaagata actttagttg ctccctgtgc      780

agttacacct ttgcatacag aacccaactt gaacgtcaca tgacatcaca taaatcagga      840

agagatcaaa gacatgtgac gcagtctggg tgtaatcgta aattcaaatg cactgagtgt      900

ggaaaagctt tcaaatacaa acatcaccta aaagagcact taagaattca cagtggagag      960

aagccatatg aatgcccaaa ctgcaagaaa cgcttttccc attctggctc ctatagctca     1020

cacataagca gtaagaaatg tatcagcttg atacctgtga atgggcgacc aagaacagga     1080

ctcaagacat ctcagtgttc ttcaccgtct ctttcagcat caccaggcag tcccacacga     1140

ccacagatac ggcaaaagat agagaataaa ccccttcaag aacaactttc tgttaaccaa     1200

attaaaactg aacctgtgga ttatgaattc aaacccatag tggttgcttc aggaatcaac     1260

tgttcaaccc ctttacaaaa tggggttttc actggtggtg gcccattaca ggcaaccagt     1320

tctcctcagg gcatggtgca agctgttgtt ctgccaacag ttggtttggt gtctcccata     1380

agtatcaatt taagtgatat tcagaatgta cttaaagtgg cggtagatgg taatgtaata     1440

aggcaagtgt tggagaataa tcaagccaat cttgcatcca aagaacaaga aacaatcaat     1500

gcttcaccca tacaacaagg tggccattct gttatttcag ccatcagtct tcctttggtt     1560

gatcaagatg gaacaaccaa aattatcatc aactacagtc ttgagcagcc tagccaactt     1620

caagttgttc ctcaaaattt aaaaaaagaa aatccagtcg ctacaaacag ttgtaaaagt     1680

gaaaagttac cagaagatct tactgttaag tctgagaagg acaaaagctt tgaagggggg     1740

gtgaatgata gcacttgtct tctgtgtgat gattgtccag gagatattaa tgcacttcca     1800

gaattaaagc actatgacct aaagcagcct actcagcctc ctccactccc tgcagcagaa     1860

gctgagaagc ctgagtcctc tgtttcatca gctactggag atggcaattt gtctcctagt     1920

cagccacctt taaagaacct cttgtctctc ctaaaagcat attatgcttt gaatgcacaa     1980

ccaagtgcag aagagctctc aaaaattgct gattcagtaa acctaccact ggatgtagta     2040

aaaaagtggt ttgaaaagat gcaagctgga cagatttcag tgcagtcttc tgaaccatct     2100

tctcctgaac caggcaaagt aaatatccct gccaagaaca atgatcagcc tcaatctgca     2160

aatgcaaatg aaccccagga cagcacagta aatctacaaa gtcctttgaa gatgactaac     2220

tccccagttt taccagtggg atcaaccacc aatggttcca gaagtagtac accatcccca     2280

tcacctctaa acctttcctc atccagaaat acacagggtt acttgtacac agctgagggt     2340

gcacaagaag agccacaagt agaacctctt gatctttcac taccaaagca acagggagaa     2400

ttattagaaa ggtcaactat cactagtgtt taccagaaca gtgtttattc tgtccaggaa     2460

gaacccttga acttgtcttg cgcaaaaaag gagccacaaa aggacagttg tgttacagac     2520

tcagaaccag ttgtaaatgt aatcccacca agtgccaacc ccataaatat cgctatacct     2580

acagtcactg cccagttacc cacaatcgtg gccattgctg accagaacag tgttccatgc     2640

ttaagagcgc tagctgccaa taagcaaacg attctgattc cccaggtggc atacacctac     2700

tcaactacgg tcagccctgc agtccaagaa ccacccttga aagtgatcca gccaaatgga     2760

aatcaggatg aaagacaaga tactagctca gaaggagtat caaatgtaga ggatcagaat     2820

gactctgatt ctacaccgcc caaaaagaaa atgcggaaga cagaaaatgg aatgtatgct     2880

tgtgatttgt gtgacaagat attccaaaag agtagttcat tattgagaca taaatatgaa     2940

cacacaggta aaagacctca tgagtgtgga atctgtaaaa aggcatttaa acacaaacat     3000

catttgattg aacacatgcg attacattct ggagaaaagc cctatcaatg tgacaaatgt     3060

ggaaagcgct tctcacactc tgggtcttat tctcaacaca tgaatcatcg ctactcctac     3120

tgtaagagag aagcggaaga acgtgacagc acagagcagg aagaggcagg gcctgaaatc     3180

ctctcgaatg agcacgtggg tgccagggcg tctccctcac agggcgactc ggacgagaga     3240

gagagtttga caagggaaga ggatgaagac agtgaaaaag aggaagagga ggaggataaa     3300

gagatggaag aattgcagga agaaaaagaa tgtgaaaaac cacaagggga tgaggaagag     3360

gaggaggagg aggaagaagt ggaagaagaa gaggtagaag aggcagagaa tgagggagaa     3420

gaagcaaaaa ctgaaggtct gatgaaggat gacagggctg aaagtcaagc aagcagctta     3480

ggacaaaaag taggcgagag tagtgagcaa gtgtctgaag aaaagacaaa tgaagcctaa     3540

tcgtttttct agaaggaaaa taaattctaa ttgataatga atttcgttca atattatcct     3600

tgcttttcat ggaaacacag taacctgtat gctgtgattc ctgttcacta ctgtgtaaag     3660

taaaaactaa aaaaatacaa aatacaaaac acacacacac acacacacac acacacacac     3720

acacacacaa aataaatccg ggtgtgcctg aacctcagac ctagtaattt ttcatgcagt     3780

tttcaaagtt aggaacaagt ttgtaacatg cagcagatta gaaaacctta atgactcaga     3840

gagcaacaat acaagaggtt aaaggaagct gattaattag atatgcatct ggcattgttt     3900

tatcttatca gtattatcac tcttatgttg gtttattctt aagctgtaca attgggagaa     3960

attttataat tttttattgg taaacatatg ctaaatccgc ttcagtattt tattatgttt     4020

tttaaaatgt gagaacttct gcactacaaa attcccttca cagagaagta taatgtagtt     4080

ccaacccgtg ctaactacct tttataaatt cagtctagaa ggtagtaatt tctaatattt     4140

agatgtctta gtagagcgta ttatcattta aagtgtattg ttagccttaa gaaagcagct     4200

gatagaagaa ctgaagtttc ttactcacgt ggtttaaaat ggagttcaaa agattgccat     4260

tgagttctga ttgcagggac taacaatgtt aatctgataa ggacagcaaa atcatcagaa     4320

tcagtgtttg tgattgtgtt tgaatatgtg gtaacatatg aaggatatga catgaagctt     4380

tgtatctcct ttggccttaa gcaagacctg tgtgctgtaa gtgccatttc tcagtatttt     4440

caaggctcta acccgccttc atccaatgtg tggcctacaa taactagcat ttgttgattt     4500

gtctcttgta tcaaaattcc caaataaaac ttaaaaccac tgactctgtc agagaaactg     4560

aaacactggg acatttcatc cttcaattcc tcggtattga ttttatgttg attgattttc     4620

agaatttctc tacagaaacg aaagggaaat tttctaatct gctttatcca tgtacttgca     4680

tttcagacat ggacatgcta ttgttatttg gctcataact gtttccaaat gttagttatt     4740

atggacccaa tttattaaca acattagctg atttttacct atcagtatta ttttatttct     4800

tttagtttat agatctgtgc aacatttttg tactgtatgt cttcaaacct ggcagtatta     4860

atacccttct tactgacata tgtactttta gttttagaaa acttttatat ttatgtgtct     4920

tatttttata tttctttatt tattacacag tgtagtgtat aatactgtag tttgtattaa     4980

tacaataata tattttagta tgaaaatttg gaaagttgat aagatttaaa gtagagatgc     5040

aattggttct cctgcattga gatttgattt aacagtgtta tgttaacatt tatacttgcc     5100

ttggactgta gaacagaact taaatgggaa tgtattagtt ttacaactac aatcaagtca     5160

ttttaccttt acccagtttt taatataaaa cttaaatttt gaaattcact gtgtgactaa     5220

tagcatgatg ctctgcagtt ttattaagaa atcagcctaa ccatacaact ctcatttcct     5280

tagtaagcca aattaggatt aacttctata aacagtgttg ggaacaatgt ttaacatttt     5340

gtgccaattt gttcctgtat tcatgtatgt aagttacaga tctgactctt catttttaag     5400

ttccttgtta catcatggtc attttctagt tttttaccag actcccatct cacaataaaa     5460

tgcatcaaca agcctgaact gctgtcattc ttttcatcat tatcagtatt ttctttggaa     5520

aactgtgaaa tggggtacat tgtcatcctg catttgattc atcttgagct gaatttgggt     5580

aacactaaat gttttagaca ttctccacta aattatggat tttcttgtgg ctaaatgttt     5640

ctggagaggt cagagttgac aaaacctctt cacaggttgc tccttcttcc tgaaatcctt     5700

aatcctccgc atttcatgct tcaggtcatt tcagggaagc ctgggtttag atgcctttct     5760

gactctcagc tcctgcactt ctgtcatcat acctctgata ctattattta tattccttcc     5820

ccactaggaa caggaaccac atttgtcata gtcactctca cattcctcac tgcctaacag     5880

ggtgcctggc ataagttggg acaacagata tttgttgaat aaaaatataa tttgcatgtt     5940

tatggagctc agctatgttc tcactttttt tgcttctaat tccagaatat atgttaaatg     6000

atctaataat ttgattattt tcttataagt cttattaaac actagtcata atagacacaa     6060

taaattatgc cttctttttc                                                 6080


<210> 62
<211> 906
<212> PRT
<213> Homo sapiens

<400> 62
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 63
<211> 6312
<212> DNA
<213> Homo sapiens

<400> 63
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgttt tcagtttaaa ttctcaactg gcaattggcc gaaaactccc      120

atctgaagac atgatcatcc aaatgtcatt ttgtgatttg gctactgtct gcttgacata      180

ggaaagcact atcaagaaag actaatggag tgactatcaa aaggaagtca atggacaacc      240

ttaaacttcc accacaagag gaatataaag aggtccctcc tgcaccaaga aagatctgca      300

gatctttttc agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt tgtgtcagcc      360

accttgttct ctaaagggaa agcccctcaa accattttgt attctgtatt acacttcaga      420

aagtgtggaa gcaaaggtca tctaatcttt aaaagttaca aattataata ctgtggtaga      480

aacaaattca gattcagatg atgaagacaa actgcatatt gtggaagaag aaagtgttac      540

agatgcagct gactgtgaag gtgtaccaga ggatgacctg ccaacagacc agacagtgtt      600

accagggagg agcagtgaaa gagaagggaa tgctaagaac tgctgggagg atgacagaaa      660

ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat gaagcaggat gtacagtaaa      720

agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac catgatccta atgttgaaga      780

gtttctacaa caacaagaca ctgctgtcat ttttcctgag gcacctgaag aggaccagag      840

gcagggcaca ccagaagcca gtggtcatga tgaaaatgga acaccagatg cattttcaca      900

attactcacc tgtccatatt gtgatagagg ctataaacgc tttacctctc tgaaagaaca      960

cattaaatat cgtcatgaaa agaatgaaga taactttagt tgctccctgt gcagttacac     1020

ctttgcatac agaacccaac ttgaacgtca catgacatca cataaatcag gaagagatca     1080

aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc     1140

tttcaaatac aaacatcacc taaaagagca cttaagaatt cacagtggag agaagccata     1200

tgaatgccca aactgcaaga aacgcttttc ccattctggc tcctatagct cacacataag     1260

cagtaagaaa tgtatcagct tgatacctgt gaatgggcga ccaagaacag gactcaagac     1320

atctcagtgt tcttcaccgt ctctttcagc atcaccaggc agtcccacac gaccacagat     1380

acggcaaaag atagagaata aaccccttca agaacaactt tctgttaacc aaattaaaac     1440

tgaacctgtg gattatgaat tcaaacccat agtggttgct tcaggaatca actgttcaac     1500

ccctttacaa aatggggttt tcactggtgg tggcccatta caggcaacca gttctcctca     1560

gggcatggtg caagctgttg ttctgccaac agttggtttg gtgtctccca taagtatcaa     1620

tttaagtgat attcagaatg tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt     1680

gttggagaat aatcaagcca atcttgcatc caaagaacaa gaaacaatca atgcttcacc     1740

catacaacaa ggtggccatt ctgttatttc agccatcagt cttcctttgg ttgatcaaga     1800

tggaacaacc aaaattatca tcaactacag tcttgagcag cctagccaac ttcaagttgt     1860

tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt     1920

accagaagat cttactgtta agtctgagaa ggacaaaagc tttgaagggg gggtgaatga     1980

tagcacttgt cttctgtgtg atgattgtcc aggagatatt aatgcacttc cagaattaaa     2040

gcactatgac ctaaagcagc ctactcagcc tcctccactc cctgcagcag aagctgagaa     2100

gcctgagtcc tctgtttcat cagctactgg agatggcaat ttgtctccta gtcagccacc     2160

tttaaagaac ctcttgtctc tcctaaaagc atattatgct ttgaatgcac aaccaagtgc     2220

agaagagctc tcaaaaattg ctgattcagt aaacctacca ctggatgtag taaaaaagtg     2280

gtttgaaaag atgcaagctg gacagatttc agtgcagtct tctgaaccat cttctcctga     2340

accaggcaaa gtaaatatcc ctgccaagaa caatgatcag cctcaatctg caaatgcaaa     2400

tgaaccccag gacagcacag taaatctaca aagtcctttg aagatgacta actccccagt     2460

tttaccagtg ggatcaacca ccaatggttc cagaagtagt acaccatccc catcacctct     2520

aaacctttcc tcatccagaa atacacaggg ttacttgtac acagctgagg gtgcacaaga     2580

agagccacaa gtagaacctc ttgatctttc actaccaaag caacagggag aattattaga     2640

aaggtcaact atcactagtg tttaccagaa cagtgtttat tctgtccagg aagaaccctt     2700

gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt tgtgttacag actcagaacc     2760

agttgtaaat gtaatcccac caagtgccaa ccccataaat atcgctatac ctacagtcac     2820

tgcccagtta cccacaatcg tggccattgc tgaccagaac agtgttccat gcttaagagc     2880

gctagctgcc aataagcaaa cgattctgat tccccaggtg gcatacacct actcaactac     2940

ggtcagccct gcagtccaag aaccaccctt gaaagtgatc cagccaaatg gaaatcagga     3000

tgaaagacaa gatactagct cagaaggagt atcaaatgta gaggatcaga atgactctga     3060

ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt     3120

gtgtgacaag atattccaaa agagtagttc attattgaga cataaatatg aacacacagg     3180

taaaagacct catgagtgtg gaatctgtaa aaaggcattt aaacacaaac atcatttgat     3240

tgaacacatg cgattacatt ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg     3300

cttctcacac tctgggtctt attctcaaca catgaatcat cgctactcct actgtaagag     3360

agaagcggaa gaacgtgaca gcacagagca ggaagaggca gggcctgaaa tcctctcgaa     3420

tgagcacgtg ggtgccaggg cgtctccctc acagggcgac tcggacgaga gagagagttt     3480

gacaagggaa gaggatgaag acagtgaaaa agaggaagag gaggaggata aagagatgga     3540

agaattgcag gaagaaaaag aatgtgaaaa accacaaggg gatgaggaag aggaggagga     3600

ggaggaagaa gtggaagaag aagaggtaga agaggcagag aatgagggag aagaagcaaa     3660

aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa gcaagcagct taggacaaaa     3720

agtaggcgag agtagtgagc aagtgtctga agaaaagaca aatgaagcct aatcgttttt     3780

ctagaaggaa aataaattct aattgataat gaatttcgtt caatattatc cttgcttttc     3840

atggaaacac agtaacctgt atgctgtgat tcctgttcac tactgtgtaa agtaaaaact     3900

aaaaaaatac aaaatacaaa acacacacac acacacacac acacacacac acacacacac     3960

aaaataaatc cgggtgtgcc tgaacctcag acctagtaat ttttcatgca gttttcaaag     4020

ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct taatgactca gagagcaaca     4080

atacaagagg ttaaaggaag ctgattaatt agatatgcat ctggcattgt tttatcttat     4140

cagtattatc actcttatgt tggtttattc ttaagctgta caattgggag aaattttata     4200

attttttatt ggtaaacata tgctaaatcc gcttcagtat tttattatgt tttttaaaat     4260

gtgagaactt ctgcactaca aaattccctt cacagagaag tataatgtag ttccaacccg     4320

tgctaactac cttttataaa ttcagtctag aaggtagtaa tttctaatat ttagatgtct     4380

tagtagagcg tattatcatt taaagtgtat tgttagcctt aagaaagcag ctgatagaag     4440

aactgaagtt tcttactcac gtggtttaaa atggagttca aaagattgcc attgagttct     4500

gattgcaggg actaacaatg ttaatctgat aaggacagca aaatcatcag aatcagtgtt     4560

tgtgattgtg tttgaatatg tggtaacata tgaaggatat gacatgaagc tttgtatctc     4620

ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc     4680

taacccgcct tcatccaatg tgtggcctac aataactagc atttgttgat ttgtctcttg     4740

tatcaaaatt cccaaataaa acttaaaacc actgactctg tcagagaaac tgaaacactg     4800

ggacatttca tccttcaatt cctcggtatt gattttatgt tgattgattt tcagaatttc     4860

tctacagaaa cgaaagggaa attttctaat ctgctttatc catgtacttg catttcagac     4920

atggacatgc tattgttatt tggctcataa ctgtttccaa atgttagtta ttatggaccc     4980

aatttattaa caacattagc tgatttttac ctatcagtat tattttattt cttttagttt     5040

atagatctgt gcaacatttt tgtactgtat gtcttcaaac ctggcagtat taataccctt     5100

cttactgaca tatgtacttt tagttttaga aaacttttat atttatgtgt cttattttta     5160

tatttcttta tttattacac agtgtagtgt ataatactgt agtttgtatt aatacaataa     5220

tatattttag tatgaaaatt tggaaagttg ataagattta aagtagagat gcaattggtt     5280

ctcctgcatt gagatttgat ttaacagtgt tatgttaaca tttatacttg ccttggactg     5340

tagaacagaa cttaaatggg aatgtattag ttttacaact acaatcaagt cattttacct     5400

ttacccagtt tttaatataa aacttaaatt ttgaaattca ctgtgtgact aatagcatga     5460

tgctctgcag ttttattaag aaatcagcct aaccatacaa ctctcatttc cttagtaagc     5520

caaattagga ttaacttcta taaacagtgt tgggaacaat gtttaacatt ttgtgccaat     5580

ttgttcctgt attcatgtat gtaagttaca gatctgactc ttcattttta agttccttgt     5640

tacatcatgg tcattttcta gttttttacc agactcccat ctcacaataa aatgcatcaa     5700

caagcctgaa ctgctgtcat tcttttcatc attatcagta ttttctttgg aaaactgtga     5760

aatggggtac attgtcatcc tgcatttgat tcatcttgag ctgaatttgg gtaacactaa     5820

atgttttaga cattctccac taaattatgg attttcttgt ggctaaatgt ttctggagag     5880

gtcagagttg acaaaacctc ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc     5940

gcatttcatg cttcaggtca tttcagggaa gcctgggttt agatgccttt ctgactctca     6000

gctcctgcac ttctgtcatc atacctctga tactattatt tatattcctt ccccactagg     6060

aacaggaacc acatttgtca tagtcactct cacattcctc actgcctaac agggtgcctg     6120

gcataagttg ggacaacaga tatttgttga ataaaaatat aatttgcatg tttatggagc     6180

tcagctatgt tctcactttt tttgcttcta attccagaat atatgttaaa tgatctaata     6240

atttgattat tttcttataa gtcttattaa acactagtca taatagacac aataaattat     6300

gccttctttt tc                                                         6312


<210> 64
<211> 906
<212> PRT
<213> Homo sapiens

<400> 64
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 65
<211> 5980
<212> DNA
<213> Homo sapiens

<400> 65
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgctg tttaaggaag acagagcagg cattggataa tattcttatt      120

aagttacaaa ttataatact gtggtagaaa caaattcaga ttcagatgat gaagacaaac      180

tgcatattgt ggaagaagaa agtgttacag atgcagctga ctgtgaaggt gtaccagagg      240

atgacctgcc aacagaccag acagtgttac cagggaggag cagtgaaaga gaagggaatg      300

ctaagaactg ctgggaggat gacagaaagg aagggcaaga aatcctgggg cctgaagctc      360

aggcagatga agcaggatgt acagtaaaag atgatgaatg cgagtcagat gcagaaaatg      420

agcaaaacca tgatcctaat gttgaagagt ttctacaaca acaagacact gctgtcattt      480

ttcctgaggc acctgaagag gaccagaggc agggcacacc agaagccagt ggtcatgatg      540

aaaatggaac accagatgca ttttcacaat tactcacctg tccatattgt gatagaggct      600

ataaacgctt tacctctctg aaagaacaca ttaaatatcg tcatgaaaag aatgaagata      660

actttagttg ctccctgtgc agttacacct ttgcatacag aacccaactt gaacgtcaca      720

tgacatcaca taaatcagga agagatcaaa gacatgtgac gcagtctggg tgtaatcgta      780

aattcaaatg cactgagtgt ggaaaagctt tcaaatacaa acatcaccta aaagagcact      840

taagaattca cagtggagag aagccatatg aatgcccaaa ctgcaagaaa cgcttttccc      900

attctggctc ctatagctca cacataagca gtaagaaatg tatcagcttg atacctgtga      960

atgggcgacc aagaacagga ctcaagacat ctcagtgttc ttcaccgtct ctttcagcat     1020

caccaggcag tcccacacga ccacagatac ggcaaaagat agagaataaa ccccttcaag     1080

aacaactttc tgttaaccaa attaaaactg aacctgtgga ttatgaattc aaacccatag     1140

tggttgcttc aggaatcaac tgttcaaccc ctttacaaaa tggggttttc actggtggtg     1200

gcccattaca ggcaaccagt tctcctcagg gcatggtgca agctgttgtt ctgccaacag     1260

ttggtttggt gtctcccata agtatcaatt taagtgatat tcagaatgta cttaaagtgg     1320

cggtagatgg taatgtaata aggcaagtgt tggagaataa tcaagccaat cttgcatcca     1380

aagaacaaga aacaatcaat gcttcaccca tacaacaagg tggccattct gttatttcag     1440

ccatcagtct tcctttggtt gatcaagatg gaacaaccaa aattatcatc aactacagtc     1500

ttgagcagcc tagccaactt caagttgttc ctcaaaattt aaaaaaagaa aatccagtcg     1560

ctacaaacag ttgtaaaagt gaaaagttac cagaagatct tactgttaag tctgagaagg     1620

acaaaagctt tgaagggggg gtgaatgata gcacttgtct tctgtgtgat gattgtccag     1680

gagatattaa tgcacttcca gaattaaagc actatgacct aaagcagcct actcagcctc     1740

ctccactccc tgcagcagaa gctgagaagc ctgagtcctc tgtttcatca gctactggag     1800

atggcaattt gtctcctagt cagccacctt taaagaacct cttgtctctc ctaaaagcat     1860

attatgcttt gaatgcacaa ccaagtgcag aagagctctc aaaaattgct gattcagtaa     1920

acctaccact ggatgtagta aaaaagtggt ttgaaaagat gcaagctgga cagatttcag     1980

tgcagtcttc tgaaccatct tctcctgaac caggcaaagt aaatatccct gccaagaaca     2040

atgatcagcc tcaatctgca aatgcaaatg aaccccagga cagcacagta aatctacaaa     2100

gtcctttgaa gatgactaac tccccagttt taccagtggg atcaaccacc aatggttcca     2160

gaagtagtac accatcccca tcacctctaa acctttcctc atccagaaat acacagggtt     2220

acttgtacac agctgagggt gcacaagaag agccacaagt agaacctctt gatctttcac     2280

taccaaagca acagggagaa ttattagaaa ggtcaactat cactagtgtt taccagaaca     2340

gtgtttattc tgtccaggaa gaacccttga acttgtcttg cgcaaaaaag gagccacaaa     2400

aggacagttg tgttacagac tcagaaccag ttgtaaatgt aatcccacca agtgccaacc     2460

ccataaatat cgctatacct acagtcactg cccagttacc cacaatcgtg gccattgctg     2520

accagaacag tgttccatgc ttaagagcgc tagctgccaa taagcaaacg attctgattc     2580

cccaggtggc atacacctac tcaactacgg tcagccctgc agtccaagaa ccacccttga     2640

aagtgatcca gccaaatgga aatcaggatg aaagacaaga tactagctca gaaggagtat     2700

caaatgtaga ggatcagaat gactctgatt ctacaccgcc caaaaagaaa atgcggaaga     2760

cagaaaatgg aatgtatgct tgtgatttgt gtgacaagat attccaaaag agtagttcat     2820

tattgagaca taaatatgaa cacacaggta aaagacctca tgagtgtgga atctgtaaaa     2880

aggcatttaa acacaaacat catttgattg aacacatgcg attacattct ggagaaaagc     2940

cctatcaatg tgacaaatgt ggaaagcgct tctcacactc tgggtcttat tctcaacaca     3000

tgaatcatcg ctactcctac tgtaagagag aagcggaaga acgtgacagc acagagcagg     3060

aagaggcagg gcctgaaatc ctctcgaatg agcacgtggg tgccagggcg tctccctcac     3120

agggcgactc ggacgagaga gagagtttga caagggaaga ggatgaagac agtgaaaaag     3180

aggaagagga ggaggataaa gagatggaag aattgcagga agaaaaagaa tgtgaaaaac     3240

cacaagggga tgaggaagag gaggaggagg aggaagaagt ggaagaagaa gaggtagaag     3300

aggcagagaa tgagggagaa gaagcaaaaa ctgaaggtct gatgaaggat gacagggctg     3360

aaagtcaagc aagcagctta ggacaaaaag taggcgagag tagtgagcaa gtgtctgaag     3420

aaaagacaaa tgaagcctaa tcgtttttct agaaggaaaa taaattctaa ttgataatga     3480

atttcgttca atattatcct tgcttttcat ggaaacacag taacctgtat gctgtgattc     3540

ctgttcacta ctgtgtaaag taaaaactaa aaaaatacaa aatacaaaac acacacacac     3600

acacacacac acacacacac acacacacaa aataaatccg ggtgtgcctg aacctcagac     3660

ctagtaattt ttcatgcagt tttcaaagtt aggaacaagt ttgtaacatg cagcagatta     3720

gaaaacctta atgactcaga gagcaacaat acaagaggtt aaaggaagct gattaattag     3780

atatgcatct ggcattgttt tatcttatca gtattatcac tcttatgttg gtttattctt     3840

aagctgtaca attgggagaa attttataat tttttattgg taaacatatg ctaaatccgc     3900

ttcagtattt tattatgttt tttaaaatgt gagaacttct gcactacaaa attcccttca     3960

cagagaagta taatgtagtt ccaacccgtg ctaactacct tttataaatt cagtctagaa     4020

ggtagtaatt tctaatattt agatgtctta gtagagcgta ttatcattta aagtgtattg     4080

ttagccttaa gaaagcagct gatagaagaa ctgaagtttc ttactcacgt ggtttaaaat     4140

ggagttcaaa agattgccat tgagttctga ttgcagggac taacaatgtt aatctgataa     4200

ggacagcaaa atcatcagaa tcagtgtttg tgattgtgtt tgaatatgtg gtaacatatg     4260

aaggatatga catgaagctt tgtatctcct ttggccttaa gcaagacctg tgtgctgtaa     4320

gtgccatttc tcagtatttt caaggctcta acccgccttc atccaatgtg tggcctacaa     4380

taactagcat ttgttgattt gtctcttgta tcaaaattcc caaataaaac ttaaaaccac     4440

tgactctgtc agagaaactg aaacactggg acatttcatc cttcaattcc tcggtattga     4500

ttttatgttg attgattttc agaatttctc tacagaaacg aaagggaaat tttctaatct     4560

gctttatcca tgtacttgca tttcagacat ggacatgcta ttgttatttg gctcataact     4620

gtttccaaat gttagttatt atggacccaa tttattaaca acattagctg atttttacct     4680

atcagtatta ttttatttct tttagtttat agatctgtgc aacatttttg tactgtatgt     4740

cttcaaacct ggcagtatta atacccttct tactgacata tgtactttta gttttagaaa     4800

acttttatat ttatgtgtct tatttttata tttctttatt tattacacag tgtagtgtat     4860

aatactgtag tttgtattaa tacaataata tattttagta tgaaaatttg gaaagttgat     4920

aagatttaaa gtagagatgc aattggttct cctgcattga gatttgattt aacagtgtta     4980

tgttaacatt tatacttgcc ttggactgta gaacagaact taaatgggaa tgtattagtt     5040

ttacaactac aatcaagtca ttttaccttt acccagtttt taatataaaa cttaaatttt     5100

gaaattcact gtgtgactaa tagcatgatg ctctgcagtt ttattaagaa atcagcctaa     5160

ccatacaact ctcatttcct tagtaagcca aattaggatt aacttctata aacagtgttg     5220

ggaacaatgt ttaacatttt gtgccaattt gttcctgtat tcatgtatgt aagttacaga     5280

tctgactctt catttttaag ttccttgtta catcatggtc attttctagt tttttaccag     5340

actcccatct cacaataaaa tgcatcaaca agcctgaact gctgtcattc ttttcatcat     5400

tatcagtatt ttctttggaa aactgtgaaa tggggtacat tgtcatcctg catttgattc     5460

atcttgagct gaatttgggt aacactaaat gttttagaca ttctccacta aattatggat     5520

tttcttgtgg ctaaatgttt ctggagaggt cagagttgac aaaacctctt cacaggttgc     5580

tccttcttcc tgaaatcctt aatcctccgc atttcatgct tcaggtcatt tcagggaagc     5640

ctgggtttag atgcctttct gactctcagc tcctgcactt ctgtcatcat acctctgata     5700

ctattattta tattccttcc ccactaggaa caggaaccac atttgtcata gtcactctca     5760

cattcctcac tgcctaacag ggtgcctggc ataagttggg acaacagata tttgttgaat     5820

aaaaatataa tttgcatgtt tatggagctc agctatgttc tcactttttt tgcttctaat     5880

tccagaatat atgttaaatg atctaataat ttgattattt tcttataagt cttattaaac     5940

actagtcata atagacacaa taaattatgc cttctttttc                           5980


<210> 66
<211> 906
<212> PRT
<213> Homo sapiens

<400> 66
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 67
<211> 6129
<212> DNA
<213> Homo sapiens

<400> 67
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacggaa agcactatca agaaagacta atggagtgac tatcaaaagg      120

aagtcaatgg acaaccttaa acttccacca caagaggaat ataaagaggt ccctcctgca      180

ccaagaaaga tctgcagatc tttttcagtg ttcttggagg tgtggggtgt gagaacttga      240

tcagtttgtg tcagccacct tgttctctaa agttacaaat tataatactg tggtagaaac      300

aaattcagat tcagatgatg aagacaaact gcatattgtg gaagaagaaa gtgttacaga      360

tgcagctgac tgtgaaggtg taccagagga tgacctgcca acagaccaga cagtgttacc      420

agggaggagc agtgaaagag aagggaatgc taagaactgc tgggaggatg acagaaagga      480

agggcaagaa atcctggggc ctgaagctca ggcagatgaa gcaggatgta cagtaaaaga      540

tgatgaatgc gagtcagatg cagaaaatga gcaaaaccat gatcctaatg ttgaagagtt      600

tctacaacaa caagacactg ctgtcatttt tcctgaggca cctgaagagg accagaggca      660

gggcacacca gaagccagtg gtcatgatga aaatggaaca ccagatgcat tttcacaatt      720

actcacctgt ccatattgtg atagaggcta taaacgcttt acctctctga aagaacacat      780

taaatatcgt catgaaaaga atgaagataa ctttagttgc tccctgtgca gttacacctt      840

tgcatacaga acccaacttg aacgtcacat gacatcacat aaatcaggaa gagatcaaag      900

acatgtgacg cagtctgggt gtaatcgtaa attcaaatgc actgagtgtg gaaaagcttt      960

caaatacaaa catcacctaa aagagcactt aagaattcac agtggagaga agccatatga     1020

atgcccaaac tgcaagaaac gcttttccca ttctggctcc tatagctcac acataagcag     1080

taagaaatgt atcagcttga tacctgtgaa tgggcgacca agaacaggac tcaagacatc     1140

tcagtgttct tcaccgtctc tttcagcatc accaggcagt cccacacgac cacagatacg     1200

gcaaaagata gagaataaac cccttcaaga acaactttct gttaaccaaa ttaaaactga     1260

acctgtggat tatgaattca aacccatagt ggttgcttca ggaatcaact gttcaacccc     1320

tttacaaaat ggggttttca ctggtggtgg cccattacag gcaaccagtt ctcctcaggg     1380

catggtgcaa gctgttgttc tgccaacagt tggtttggtg tctcccataa gtatcaattt     1440

aagtgatatt cagaatgtac ttaaagtggc ggtagatggt aatgtaataa ggcaagtgtt     1500

ggagaataat caagccaatc ttgcatccaa agaacaagaa acaatcaatg cttcacccat     1560

acaacaaggt ggccattctg ttatttcagc catcagtctt cctttggttg atcaagatgg     1620

aacaaccaaa attatcatca actacagtct tgagcagcct agccaacttc aagttgttcc     1680

tcaaaattta aaaaaagaaa atccagtcgc tacaaacagt tgtaaaagtg aaaagttacc     1740

agaagatctt actgttaagt ctgagaagga caaaagcttt gaaggggggg tgaatgatag     1800

cacttgtctt ctgtgtgatg attgtccagg agatattaat gcacttccag aattaaagca     1860

ctatgaccta aagcagccta ctcagcctcc tccactccct gcagcagaag ctgagaagcc     1920

tgagtcctct gtttcatcag ctactggaga tggcaatttg tctcctagtc agccaccttt     1980

aaagaacctc ttgtctctcc taaaagcata ttatgctttg aatgcacaac caagtgcaga     2040

agagctctca aaaattgctg attcagtaaa cctaccactg gatgtagtaa aaaagtggtt     2100

tgaaaagatg caagctggac agatttcagt gcagtcttct gaaccatctt ctcctgaacc     2160

aggcaaagta aatatccctg ccaagaacaa tgatcagcct caatctgcaa atgcaaatga     2220

accccaggac agcacagtaa atctacaaag tcctttgaag atgactaact ccccagtttt     2280

accagtggga tcaaccacca atggttccag aagtagtaca ccatccccat cacctctaaa     2340

cctttcctca tccagaaata cacagggtta cttgtacaca gctgagggtg cacaagaaga     2400

gccacaagta gaacctcttg atctttcact accaaagcaa cagggagaat tattagaaag     2460

gtcaactatc actagtgttt accagaacag tgtttattct gtccaggaag aacccttgaa     2520

cttgtcttgc gcaaaaaagg agccacaaaa ggacagttgt gttacagact cagaaccagt     2580

tgtaaatgta atcccaccaa gtgccaaccc cataaatatc gctataccta cagtcactgc     2640

ccagttaccc acaatcgtgg ccattgctga ccagaacagt gttccatgct taagagcgct     2700

agctgccaat aagcaaacga ttctgattcc ccaggtggca tacacctact caactacggt     2760

cagccctgca gtccaagaac cacccttgaa agtgatccag ccaaatggaa atcaggatga     2820

aagacaagat actagctcag aaggagtatc aaatgtagag gatcagaatg actctgattc     2880

tacaccgccc aaaaagaaaa tgcggaagac agaaaatgga atgtatgctt gtgatttgtg     2940

tgacaagata ttccaaaaga gtagttcatt attgagacat aaatatgaac acacaggtaa     3000

aagacctcat gagtgtggaa tctgtaaaaa ggcatttaaa cacaaacatc atttgattga     3060

acacatgcga ttacattctg gagaaaagcc ctatcaatgt gacaaatgtg gaaagcgctt     3120

ctcacactct gggtcttatt ctcaacacat gaatcatcgc tactcctact gtaagagaga     3180

agcggaagaa cgtgacagca cagagcagga agaggcaggg cctgaaatcc tctcgaatga     3240

gcacgtgggt gccagggcgt ctccctcaca gggcgactcg gacgagagag agagtttgac     3300

aagggaagag gatgaagaca gtgaaaaaga ggaagaggag gaggataaag agatggaaga     3360

attgcaggaa gaaaaagaat gtgaaaaacc acaaggggat gaggaagagg aggaggagga     3420

ggaagaagtg gaagaagaag aggtagaaga ggcagagaat gagggagaag aagcaaaaac     3480

tgaaggtctg atgaaggatg acagggctga aagtcaagca agcagcttag gacaaaaagt     3540

aggcgagagt agtgagcaag tgtctgaaga aaagacaaat gaagcctaat cgtttttcta     3600

gaaggaaaat aaattctaat tgataatgaa tttcgttcaa tattatcctt gcttttcatg     3660

gaaacacagt aacctgtatg ctgtgattcc tgttcactac tgtgtaaagt aaaaactaaa     3720

aaaatacaaa atacaaaaca cacacacaca cacacacaca cacacacaca cacacacaaa     3780

ataaatccgg gtgtgcctga acctcagacc tagtaatttt tcatgcagtt ttcaaagtta     3840

ggaacaagtt tgtaacatgc agcagattag aaaaccttaa tgactcagag agcaacaata     3900

caagaggtta aaggaagctg attaattaga tatgcatctg gcattgtttt atcttatcag     3960

tattatcact cttatgttgg tttattctta agctgtacaa ttgggagaaa ttttataatt     4020

ttttattggt aaacatatgc taaatccgct tcagtatttt attatgtttt ttaaaatgtg     4080

agaacttctg cactacaaaa ttcccttcac agagaagtat aatgtagttc caacccgtgc     4140

taactacctt ttataaattc agtctagaag gtagtaattt ctaatattta gatgtcttag     4200

tagagcgtat tatcatttaa agtgtattgt tagccttaag aaagcagctg atagaagaac     4260

tgaagtttct tactcacgtg gtttaaaatg gagttcaaaa gattgccatt gagttctgat     4320

tgcagggact aacaatgtta atctgataag gacagcaaaa tcatcagaat cagtgtttgt     4380

gattgtgttt gaatatgtgg taacatatga aggatatgac atgaagcttt gtatctcctt     4440

tggccttaag caagacctgt gtgctgtaag tgccatttct cagtattttc aaggctctaa     4500

cccgccttca tccaatgtgt ggcctacaat aactagcatt tgttgatttg tctcttgtat     4560

caaaattccc aaataaaact taaaaccact gactctgtca gagaaactga aacactggga     4620

catttcatcc ttcaattcct cggtattgat tttatgttga ttgattttca gaatttctct     4680

acagaaacga aagggaaatt ttctaatctg ctttatccat gtacttgcat ttcagacatg     4740

gacatgctat tgttatttgg ctcataactg tttccaaatg ttagttatta tggacccaat     4800

ttattaacaa cattagctga tttttaccta tcagtattat tttatttctt ttagtttata     4860

gatctgtgca acatttttgt actgtatgtc ttcaaacctg gcagtattaa tacccttctt     4920

actgacatat gtacttttag ttttagaaaa cttttatatt tatgtgtctt atttttatat     4980

ttctttattt attacacagt gtagtgtata atactgtagt ttgtattaat acaataatat     5040

attttagtat gaaaatttgg aaagttgata agatttaaag tagagatgca attggttctc     5100

ctgcattgag atttgattta acagtgttat gttaacattt atacttgcct tggactgtag     5160

aacagaactt aaatgggaat gtattagttt tacaactaca atcaagtcat tttaccttta     5220

cccagttttt aatataaaac ttaaattttg aaattcactg tgtgactaat agcatgatgc     5280

tctgcagttt tattaagaaa tcagcctaac catacaactc tcatttcctt agtaagccaa     5340

attaggatta acttctataa acagtgttgg gaacaatgtt taacattttg tgccaatttg     5400

ttcctgtatt catgtatgta agttacagat ctgactcttc atttttaagt tccttgttac     5460

atcatggtca ttttctagtt ttttaccaga ctcccatctc acaataaaat gcatcaacaa     5520

gcctgaactg ctgtcattct tttcatcatt atcagtattt tctttggaaa actgtgaaat     5580

ggggtacatt gtcatcctgc atttgattca tcttgagctg aatttgggta acactaaatg     5640

ttttagacat tctccactaa attatggatt ttcttgtggc taaatgtttc tggagaggtc     5700

agagttgaca aaacctcttc acaggttgct ccttcttcct gaaatcctta atcctccgca     5760

tttcatgctt caggtcattt cagggaagcc tgggtttaga tgcctttctg actctcagct     5820

cctgcacttc tgtcatcata cctctgatac tattatttat attccttccc cactaggaac     5880

aggaaccaca tttgtcatag tcactctcac attcctcact gcctaacagg gtgcctggca     5940

taagttggga caacagatat ttgttgaata aaaatataat ttgcatgttt atggagctca     6000

gctatgttct cacttttttt gcttctaatt ccagaatata tgttaaatga tctaataatt     6060

tgattatttt cttataagtc ttattaaaca ctagtcataa tagacacaat aaattatgcc     6120

ttctttttc                                                             6129


<210> 68
<211> 906
<212> PRT
<213> Homo sapiens

<400> 68
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 69
<211> 6236
<212> DNA
<213> Homo sapiens

<400> 69
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgttt tcagtttaaa ttctcaactg gcaattggcc gaaaactccc      120

atctgaagac atgatcatcc aaatgtcatt ttgtgatttg gctactgtct gcttgacata      180

ggaaagcact atcaagaaag actaatggag tgactatcaa aaggaagtca atggacaacc      240

ttaaacttcc accacaagag gaatataaag aggtccctcc tgcaccaaga aagatctgca      300

gatctttttc agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt tgtgtcagcc      360

accttgttct ctaaagttac aaattataat actgtggtag aaacaaattc agattcagat      420

gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc tgactgtgaa      480

ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag gagcagtgaa      540

agagaaggga atgctaagaa ctgctgggag gatgacacag gaaaggaagg gcaagaaatc      600

ctggggcctg aagctcaggc agatgaagca ggatgtacag taaaagatga tgaatgcgag      660

tcagatgcag aaaatgagca aaaccatgat cctaatgttg aagagtttct acaacaacaa      720

gacactgctg tcatttttcc tgaggcacct gaagaggacc agaggcaggg cacaccagaa      780

gccagtggtc atgatgaaaa tggaacacca gatgcatttt cacaattact cacctgtcca      840

tattgtgata gaggctataa acgctttacc tctctgaaag aacacattaa atatcgtcat      900

gaaaagaatg aagataactt tagttgctcc ctgtgcagtt acacctttgc atacagaacc      960

caacttgaac gtcacatgac atcacataaa tcaggaagag atcaaagaca tgtgacgcag     1020

tctgggtgta atcgtaaatt caaatgcact gagtgtggaa aagctttcaa atacaaacat     1080

cacctaaaag agcacttaag aattcacagt ggagagaagc catatgaatg cccaaactgc     1140

aagaaacgct tttcccattc tggctcctat agctcacaca taagcagtaa gaaatgtatc     1200

agcttgatac ctgtgaatgg gcgaccaaga acaggactca agacatctca gtgttcttca     1260

ccgtctcttt cagcatcacc aggcagtccc acacgaccac agatacggca aaagatagag     1320

aataaacccc ttcaagaaca actttctgtt aaccaaatta aaactgaacc tgtggattat     1380

gaattcaaac ccatagtggt tgcttcagga atcaactgtt caaccccttt acaaaatggg     1440

gttttcactg gtggtggccc attacaggca accagttctc ctcagggcat ggtgcaagct     1500

gttgttctgc caacagttgg tttggtgtct cccataagta tcaatttaag tgatattcag     1560

aatgtactta aagtggcggt agatggtaat gtaataaggc aagtgttgga gaataatcaa     1620

gccaatcttg catccaaaga acaagaaaca atcaatgctt cacccataca acaaggtggc     1680

cattctgtta tttcagccat cagtcttcct ttggttgatc aagatggaac aaccaaaatt     1740

atcatcaact acagtcttga gcagcctagc caacttcaag ttgttcctca aaatttaaaa     1800

aaagaaaatc cagtcgctac aaacagttgt aaaagtgaaa agttaccaga agatcttact     1860

gttaagtctg agaaggacaa aagctttgaa gggggggtga atgatagcac ttgtcttctg     1920

tgtgatgatt gtccaggaga tattaatgca cttccagaat taaagcacta tgacctaaag     1980

cagcctactc agcctcctcc actccctgca gcagaagctg agaagcctga gtcctctgtt     2040

tcatcagcta ctggagatgg caatttgtct cctagtcagc cacctttaaa gaacctcttg     2100

tctctcctaa aagcatatta tgctttgaat gcacaaccaa gtgcagaaga gctctcaaaa     2160

attgctgatt cagtaaacct accactggat gtagtaaaaa agtggtttga aaagatgcaa     2220

gctggacaga tttcagtgca gtcttctgaa ccatcttctc ctgaaccagg caaagtaaat     2280

atccctgcca agaacaatga tcagcctcaa tctgcaaatg caaatgaacc ccaggacagc     2340

acagtaaatc tacaaagtcc tttgaagatg actaactccc cagttttacc agtgggatca     2400

accaccaatg gttccagaag tagtacacca tccccatcac ctctaaacct ttcctcatcc     2460

agaaatacac agggttactt gtacacagct gagggtgcac aagaagagcc acaagtagaa     2520

cctcttgatc tttcactacc aaagcaacag ggagaattat tagaaaggtc aactatcact     2580

agtgtttacc agaacagtgt ttattctgtc caggaagaac ccttgaactt gtcttgcgca     2640

aaaaaggagc cacaaaagga cagttgtgtt acagactcag aaccagttgt aaatgtaatc     2700

ccaccaagtg ccaaccccat aaatatcgct atacctacag tcactgccca gttacccaca     2760

atcgtggcca ttgctgacca gaacagtgtt ccatgcttaa gagcgctagc tgccaataag     2820

caaacgattc tgattcccca ggtggcatac acctactcaa ctacggtcag ccctgcagtc     2880

caagaaccac ccttgaaagt gatccagcca aatggaaatc aggatgaaag acaagatact     2940

agctcagaag gagtatcaaa tgtagaggat cagaatgact ctgattctac accgcccaaa     3000

aagaaaatgc ggaagacaga aaatggaatg tatgcttgtg atttgtgtga caagatattc     3060

caaaagagta gttcattatt gagacataaa tatgaacaca caggtaaaag acctcatgag     3120

tgtggaatct gtaaaaaggc atttaaacac aaacatcatt tgattgaaca catgcgatta     3180

cattctggag aaaagcccta tcaatgtgac aaatgtggaa agcgcttctc acactctggg     3240

tcttattctc aacacatgaa tcatcgctac tcctactgta agagagaagc ggaagaacgt     3300

gacagcacag agcaggaaga ggcagggcct gaaatcctct cgaatgagca cgtgggtgcc     3360

agggcgtctc cctcacaggg cgactcggac gagagagaga gtttgacaag ggaagaggat     3420

gaagacagtg aaaaagagga agaggaggag gataaagaga tggaagaatt gcaggaagaa     3480

aaagaatgtg aaaaaccaca aggggatgag gaagaggagg aggaggagga agaagtggaa     3540

gaagaagagg tagaagaggc agagaatgag ggagaagaag caaaaactga aggtctgatg     3600

aaggatgaca gggctgaaag tcaagcaagc agcttaggac aaaaagtagg cgagagtagt     3660

gagcaagtgt ctgaagaaaa gacaaatgaa gcctaatcgt ttttctagaa ggaaaataaa     3720

ttctaattga taatgaattt cgttcaatat tatccttgct tttcatggaa acacagtaac     3780

ctgtatgctg tgattcctgt tcactactgt gtaaagtaaa aactaaaaaa atacaaaata     3840

caaaacacac acacacacac acacacacac acacacacac acacaaaata aatccgggtg     3900

tgcctgaacc tcagacctag taatttttca tgcagttttc aaagttagga acaagtttgt     3960

aacatgcagc agattagaaa accttaatga ctcagagagc aacaatacaa gaggttaaag     4020

gaagctgatt aattagatat gcatctggca ttgttttatc ttatcagtat tatcactctt     4080

atgttggttt attcttaagc tgtacaattg ggagaaattt tataattttt tattggtaaa     4140

catatgctaa atccgcttca gtattttatt atgtttttta aaatgtgaga acttctgcac     4200

tacaaaattc ccttcacaga gaagtataat gtagttccaa cccgtgctaa ctacctttta     4260

taaattcagt ctagaaggta gtaatttcta atatttagat gtcttagtag agcgtattat     4320

catttaaagt gtattgttag ccttaagaaa gcagctgata gaagaactga agtttcttac     4380

tcacgtggtt taaaatggag ttcaaaagat tgccattgag ttctgattgc agggactaac     4440

aatgttaatc tgataaggac agcaaaatca tcagaatcag tgtttgtgat tgtgtttgaa     4500

tatgtggtaa catatgaagg atatgacatg aagctttgta tctcctttgg ccttaagcaa     4560

gacctgtgtg ctgtaagtgc catttctcag tattttcaag gctctaaccc gccttcatcc     4620

aatgtgtggc ctacaataac tagcatttgt tgatttgtct cttgtatcaa aattcccaaa     4680

taaaacttaa aaccactgac tctgtcagag aaactgaaac actgggacat ttcatccttc     4740

aattcctcgg tattgatttt atgttgattg attttcagaa tttctctaca gaaacgaaag     4800

ggaaattttc taatctgctt tatccatgta cttgcatttc agacatggac atgctattgt     4860

tatttggctc ataactgttt ccaaatgtta gttattatgg acccaattta ttaacaacat     4920

tagctgattt ttacctatca gtattatttt atttctttta gtttatagat ctgtgcaaca     4980

tttttgtact gtatgtcttc aaacctggca gtattaatac ccttcttact gacatatgta     5040

cttttagttt tagaaaactt ttatatttat gtgtcttatt tttatatttc tttatttatt     5100

acacagtgta gtgtataata ctgtagtttg tattaataca ataatatatt ttagtatgaa     5160

aatttggaaa gttgataaga tttaaagtag agatgcaatt ggttctcctg cattgagatt     5220

tgatttaaca gtgttatgtt aacatttata cttgccttgg actgtagaac agaacttaaa     5280

tgggaatgta ttagttttac aactacaatc aagtcatttt acctttaccc agtttttaat     5340

ataaaactta aattttgaaa ttcactgtgt gactaatagc atgatgctct gcagttttat     5400

taagaaatca gcctaaccat acaactctca tttccttagt aagccaaatt aggattaact     5460

tctataaaca gtgttgggaa caatgtttaa cattttgtgc caatttgttc ctgtattcat     5520

gtatgtaagt tacagatctg actcttcatt tttaagttcc ttgttacatc atggtcattt     5580

tctagttttt taccagactc ccatctcaca ataaaatgca tcaacaagcc tgaactgctg     5640

tcattctttt catcattatc agtattttct ttggaaaact gtgaaatggg gtacattgtc     5700

atcctgcatt tgattcatct tgagctgaat ttgggtaaca ctaaatgttt tagacattct     5760

ccactaaatt atggattttc ttgtggctaa atgtttctgg agaggtcaga gttgacaaaa     5820

cctcttcaca ggttgctcct tcttcctgaa atccttaatc ctccgcattt catgcttcag     5880

gtcatttcag ggaagcctgg gtttagatgc ctttctgact ctcagctcct gcacttctgt     5940

catcatacct ctgatactat tatttatatt ccttccccac taggaacagg aaccacattt     6000

gtcatagtca ctctcacatt cctcactgcc taacagggtg cctggcataa gttgggacaa     6060

cagatatttg ttgaataaaa atataatttg catgtttatg gagctcagct atgttctcac     6120

tttttttgct tctaattcca gaatatatgt taaatgatct aataatttga ttattttctt     6180

ataagtctta ttaaacacta gtcataatag acacaataaa ttatgccttc tttttc         6236


<210> 70
<211> 906
<212> PRT
<213> Homo sapiens

<400> 70
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 71
<211> 6123
<212> DNA
<213> Homo sapiens

<400> 71
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgctg tttaaggaag acagagcagg cattggataa tattcttatt      120

aaggacaacc ttaaacttcc accacaagag gaatataaag aggtccctcc tgcaccaaga      180

aagatctgca gatctttttc agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt      240

tgtgtcagcc accttgttct ctaaagttac aaattataat actgtggtag aaacaaattc      300

agattcagat gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc      360

tgactgtgaa ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag      420

gagcagtgaa agagaaggga atgctaagaa ctgctgggag gatgacagaa aggaagggca      480

agaaatcctg gggcctgaag ctcaggcaga tgaagcagga tgtacagtaa aagatgatga      540

atgcgagtca gatgcagaaa atgagcaaaa ccatgatcct aatgttgaag agtttctaca      600

acaacaagac actgctgtca tttttcctga ggcacctgaa gaggaccaga ggcagggcac      660

accagaagcc agtggtcatg atgaaaatgg aacaccagat gcattttcac aattactcac      720

ctgtccatat tgtgatagag gctataaacg ctttacctct ctgaaagaac acattaaata      780

tcgtcatgaa aagaatgaag ataactttag ttgctccctg tgcagttaca cctttgcata      840

cagaacccaa cttgaacgtc acatgacatc acataaatca ggaagagatc aaagacatgt      900

gacgcagtct gggtgtaatc gtaaattcaa atgcactgag tgtggaaaag ctttcaaata      960

caaacatcac ctaaaagagc acttaagaat tcacagtgga gagaagccat atgaatgccc     1020

aaactgcaag aaacgctttt cccattctgg ctcctatagc tcacacataa gcagtaagaa     1080

atgtatcagc ttgatacctg tgaatgggcg accaagaaca ggactcaaga catctcagtg     1140

ttcttcaccg tctctttcag catcaccagg cagtcccaca cgaccacaga tacggcaaaa     1200

gatagagaat aaaccccttc aagaacaact ttctgttaac caaattaaaa ctgaacctgt     1260

ggattatgaa ttcaaaccca tagtggttgc ttcaggaatc aactgttcaa cccctttaca     1320

aaatggggtt ttcactggtg gtggcccatt acaggcaacc agttctcctc agggcatggt     1380

gcaagctgtt gttctgccaa cagttggttt ggtgtctccc ataagtatca atttaagtga     1440

tattcagaat gtacttaaag tggcggtaga tggtaatgta ataaggcaag tgttggagaa     1500

taatcaagcc aatcttgcat ccaaagaaca agaaacaatc aatgcttcac ccatacaaca     1560

aggtggccat tctgttattt cagccatcag tcttcctttg gttgatcaag atggaacaac     1620

caaaattatc atcaactaca gtcttgagca gcctagccaa cttcaagttg ttcctcaaaa     1680

tttaaaaaaa gaaaatccag tcgctacaaa cagttgtaaa agtgaaaagt taccagaaga     1740

tcttactgtt aagtctgaga aggacaaaag ctttgaaggg ggggtgaatg atagcacttg     1800

tcttctgtgt gatgattgtc caggagatat taatgcactt ccagaattaa agcactatga     1860

cctaaagcag cctactcagc ctcctccact ccctgcagca gaagctgaga agcctgagtc     1920

ctctgtttca tcagctactg gagatggcaa tttgtctcct agtcagccac ctttaaagaa     1980

cctcttgtct ctcctaaaag catattatgc tttgaatgca caaccaagtg cagaagagct     2040

ctcaaaaatt gctgattcag taaacctacc actggatgta gtaaaaaagt ggtttgaaaa     2100

gatgcaagct ggacagattt cagtgcagtc ttctgaacca tcttctcctg aaccaggcaa     2160

agtaaatatc cctgccaaga acaatgatca gcctcaatct gcaaatgcaa atgaacccca     2220

ggacagcaca gtaaatctac aaagtccttt gaagatgact aactccccag ttttaccagt     2280

gggatcaacc accaatggtt ccagaagtag tacaccatcc ccatcacctc taaacctttc     2340

ctcatccaga aatacacagg gttacttgta cacagctgag ggtgcacaag aagagccaca     2400

agtagaacct cttgatcttt cactaccaaa gcaacaggga gaattattag aaaggtcaac     2460

tatcactagt gtttaccaga acagtgttta ttctgtccag gaagaaccct tgaacttgtc     2520

ttgcgcaaaa aaggagccac aaaaggacag ttgtgttaca gactcagaac cagttgtaaa     2580

tgtaatccca ccaagtgcca accccataaa tatcgctata cctacagtca ctgcccagtt     2640

acccacaatc gtggccattg ctgaccagaa cagtgttcca tgcttaagag cgctagctgc     2700

caataagcaa acgattctga ttccccaggt ggcatacacc tactcaacta cggtcagccc     2760

tgcagtccaa gaaccaccct tgaaagtgat ccagccaaat ggaaatcagg atgaaagaca     2820

agatactagc tcagaaggag tatcaaatgt agaggatcag aatgactctg attctacacc     2880

gcccaaaaag aaaatgcgga agacagaaaa tggaatgtat gcttgtgatt tgtgtgacaa     2940

gatattccaa aagagtagtt cattattgag acataaatat gaacacacag gtaaaagacc     3000

tcatgagtgt ggaatctgta aaaaggcatt taaacacaaa catcatttga ttgaacacat     3060

gcgattacat tctggagaaa agccctatca atgtgacaaa tgtggaaagc gcttctcaca     3120

ctctgggtct tattctcaac acatgaatca tcgctactcc tactgtaaga gagaagcgga     3180

agaacgtgac agcacagagc aggaagaggc agggcctgaa atcctctcga atgagcacgt     3240

gggtgccagg gcgtctccct cacagggcga ctcggacgag agagagagtt tgacaaggga     3300

agaggatgaa gacagtgaaa aagaggaaga ggaggaggat aaagagatgg aagaattgca     3360

ggaagaaaaa gaatgtgaaa aaccacaagg ggatgaggaa gaggaggagg aggaggaaga     3420

agtggaagaa gaagaggtag aagaggcaga gaatgaggga gaagaagcaa aaactgaagg     3480

tctgatgaag gatgacaggg ctgaaagtca agcaagcagc ttaggacaaa aagtaggcga     3540

gagtagtgag caagtgtctg aagaaaagac aaatgaagcc taatcgtttt tctagaagga     3600

aaataaattc taattgataa tgaatttcgt tcaatattat ccttgctttt catggaaaca     3660

cagtaacctg tatgctgtga ttcctgttca ctactgtgta aagtaaaaac taaaaaaata     3720

caaaatacaa aacacacaca cacacacaca cacacacaca cacacacaca caaaataaat     3780

ccgggtgtgc ctgaacctca gacctagtaa tttttcatgc agttttcaaa gttaggaaca     3840

agtttgtaac atgcagcaga ttagaaaacc ttaatgactc agagagcaac aatacaagag     3900

gttaaaggaa gctgattaat tagatatgca tctggcattg ttttatctta tcagtattat     3960

cactcttatg ttggtttatt cttaagctgt acaattggga gaaattttat aattttttat     4020

tggtaaacat atgctaaatc cgcttcagta ttttattatg ttttttaaaa tgtgagaact     4080

tctgcactac aaaattccct tcacagagaa gtataatgta gttccaaccc gtgctaacta     4140

ccttttataa attcagtcta gaaggtagta atttctaata tttagatgtc ttagtagagc     4200

gtattatcat ttaaagtgta ttgttagcct taagaaagca gctgatagaa gaactgaagt     4260

ttcttactca cgtggtttaa aatggagttc aaaagattgc cattgagttc tgattgcagg     4320

gactaacaat gttaatctga taaggacagc aaaatcatca gaatcagtgt ttgtgattgt     4380

gtttgaatat gtggtaacat atgaaggata tgacatgaag ctttgtatct cctttggcct     4440

taagcaagac ctgtgtgctg taagtgccat ttctcagtat tttcaaggct ctaacccgcc     4500

ttcatccaat gtgtggccta caataactag catttgttga tttgtctctt gtatcaaaat     4560

tcccaaataa aacttaaaac cactgactct gtcagagaaa ctgaaacact gggacatttc     4620

atccttcaat tcctcggtat tgattttatg ttgattgatt ttcagaattt ctctacagaa     4680

acgaaaggga aattttctaa tctgctttat ccatgtactt gcatttcaga catggacatg     4740

ctattgttat ttggctcata actgtttcca aatgttagtt attatggacc caatttatta     4800

acaacattag ctgattttta cctatcagta ttattttatt tcttttagtt tatagatctg     4860

tgcaacattt ttgtactgta tgtcttcaaa cctggcagta ttaataccct tcttactgac     4920

atatgtactt ttagttttag aaaactttta tatttatgtg tcttattttt atatttcttt     4980

atttattaca cagtgtagtg tataatactg tagtttgtat taatacaata atatatttta     5040

gtatgaaaat ttggaaagtt gataagattt aaagtagaga tgcaattggt tctcctgcat     5100

tgagatttga tttaacagtg ttatgttaac atttatactt gccttggact gtagaacaga     5160

acttaaatgg gaatgtatta gttttacaac tacaatcaag tcattttacc tttacccagt     5220

ttttaatata aaacttaaat tttgaaattc actgtgtgac taatagcatg atgctctgca     5280

gttttattaa gaaatcagcc taaccataca actctcattt ccttagtaag ccaaattagg     5340

attaacttct ataaacagtg ttgggaacaa tgtttaacat tttgtgccaa tttgttcctg     5400

tattcatgta tgtaagttac agatctgact cttcattttt aagttccttg ttacatcatg     5460

gtcattttct agttttttac cagactccca tctcacaata aaatgcatca acaagcctga     5520

actgctgtca ttcttttcat cattatcagt attttctttg gaaaactgtg aaatggggta     5580

cattgtcatc ctgcatttga ttcatcttga gctgaatttg ggtaacacta aatgttttag     5640

acattctcca ctaaattatg gattttcttg tggctaaatg tttctggaga ggtcagagtt     5700

gacaaaacct cttcacaggt tgctccttct tcctgaaatc cttaatcctc cgcatttcat     5760

gcttcaggtc atttcaggga agcctgggtt tagatgcctt tctgactctc agctcctgca     5820

cttctgtcat catacctctg atactattat ttatattcct tccccactag gaacaggaac     5880

cacatttgtc atagtcactc tcacattcct cactgcctaa cagggtgcct ggcataagtt     5940

gggacaacag atatttgttg aataaaaata taatttgcat gtttatggag ctcagctatg     6000

ttctcacttt ttttgcttct aattccagaa tatatgttaa atgatctaat aatttgatta     6060

ttttcttata agtcttatta aacactagtc ataatagaca caataaatta tgccttcttt     6120

ttc                                                                   6123


<210> 72
<211> 906
<212> PRT
<213> Homo sapiens

<400> 72
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 73
<211> 6233
<212> DNA
<213> Homo sapiens

<400> 73
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgttt tcagtttaaa ttctcaactg gcaattggcc gaaaactccc      120

atctgaagac atgatcatcc aaatgtcatt ttgtgatttg gctactgtct gcttgacata      180

ggaaagcact atcaagaaag actaatggag tgactatcaa aaggaagtca atggacaacc      240

ttaaacttcc accacaagag gaatataaag aggtccctcc tgcaccaaga aagatctgca      300

gatctttttc agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt tgtgtcagcc      360

accttgttct ctaaagttac aaattataat actgtggtag aaacaaattc agattcagat      420

gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc tgactgtgaa      480

ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag gagcagtgaa      540

agagaaggga atgctaagaa ctgctgggag gatgacagaa aggaagggca agaaatcctg      600

gggcctgaag ctcaggcaga tgaagcagga tgtacagtaa aagatgatga atgcgagtca      660

gatgcagaaa atgagcaaaa ccatgatcct aatgttgaag agtttctaca acaacaagac      720

actgctgtca tttttcctga ggcacctgaa gaggaccaga ggcagggcac accagaagcc      780

agtggtcatg atgaaaatgg aacaccagat gcattttcac aattactcac ctgtccatat      840

tgtgatagag gctataaacg ctttacctct ctgaaagaac acattaaata tcgtcatgaa      900

aagaatgaag ataactttag ttgctccctg tgcagttaca cctttgcata cagaacccaa      960

cttgaacgtc acatgacatc acataaatca ggaagagatc aaagacatgt gacgcagtct     1020

gggtgtaatc gtaaattcaa atgcactgag tgtggaaaag ctttcaaata caaacatcac     1080

ctaaaagagc acttaagaat tcacagtgga gagaagccat atgaatgccc aaactgcaag     1140

aaacgctttt cccattctgg ctcctatagc tcacacataa gcagtaagaa atgtatcagc     1200

ttgatacctg tgaatgggcg accaagaaca ggactcaaga catctcagtg ttcttcaccg     1260

tctctttcag catcaccagg cagtcccaca cgaccacaga tacggcaaaa gatagagaat     1320

aaaccccttc aagaacaact ttctgttaac caaattaaaa ctgaacctgt ggattatgaa     1380

ttcaaaccca tagtggttgc ttcaggaatc aactgttcaa cccctttaca aaatggggtt     1440

ttcactggtg gtggcccatt acaggcaacc agttctcctc agggcatggt gcaagctgtt     1500

gttctgccaa cagttggttt ggtgtctccc ataagtatca atttaagtga tattcagaat     1560

gtacttaaag tggcggtaga tggtaatgta ataaggcaag tgttggagaa taatcaagcc     1620

aatcttgcat ccaaagaaca agaaacaatc aatgcttcac ccatacaaca aggtggccat     1680

tctgttattt cagccatcag tcttcctttg gttgatcaag atggaacaac caaaattatc     1740

atcaactaca gtcttgagca gcctagccaa cttcaagttg ttcctcaaaa tttaaaaaaa     1800

gaaaatccag tcgctacaaa cagttgtaaa agtgaaaagt taccagaaga tcttactgtt     1860

aagtctgaga aggacaaaag ctttgaaggg ggggtgaatg atagcacttg tcttctgtgt     1920

gatgattgtc caggagatat taatgcactt ccagaattaa agcactatga cctaaagcag     1980

cctactcagc ctcctccact ccctgcagca gaagctgaga agcctgagtc ctctgtttca     2040

tcagctactg gagatggcaa tttgtctcct agtcagccac ctttaaagaa cctcttgtct     2100

ctcctaaaag catattatgc tttgaatgca caaccaagtg cagaagagct ctcaaaaatt     2160

gctgattcag taaacctacc actggatgta gtaaaaaagt ggtttgaaaa gatgcaagct     2220

ggacagattt cagtgcagtc ttctgaacca tcttctcctg aaccaggcaa agtaaatatc     2280

cctgccaaga acaatgatca gcctcaatct gcaaatgcaa atgaacccca ggacagcaca     2340

gtaaatctac aaagtccttt gaagatgact aactccccag ttttaccagt gggatcaacc     2400

accaatggtt ccagaagtag tacaccatcc ccatcacctc taaacctttc ctcatccaga     2460

aatacacagg gttacttgta cacagctgag ggtgcacaag aagagccaca agtagaacct     2520

cttgatcttt cactaccaaa gcaacaggga gaattattag aaaggtcaac tatcactagt     2580

gtttaccaga acagtgttta ttctgtccag gaagaaccct tgaacttgtc ttgcgcaaaa     2640

aaggagccac aaaaggacag ttgtgttaca gactcagaac cagttgtaaa tgtaatccca     2700

ccaagtgcca accccataaa tatcgctata cctacagtca ctgcccagtt acccacaatc     2760

gtggccattg ctgaccagaa cagtgttcca tgcttaagag cgctagctgc caataagcaa     2820

acgattctga ttccccaggt ggcatacacc tactcaacta cggtcagccc tgcagtccaa     2880

gaaccaccct tgaaagtgat ccagccaaat ggaaatcagg atgaaagaca agatactagc     2940

tcagaaggag tatcaaatgt agaggatcag aatgactctg attctacacc gcccaaaaag     3000

aaaatgcgga agacagaaaa tggaatgtat gcttgtgatt tgtgtgacaa gatattccaa     3060

aagagtagtt cattattgag acataaatat gaacacacag gtaaaagacc tcatgagtgt     3120

ggaatctgta aaaaggcatt taaacacaaa catcatttga ttgaacacat gcgattacat     3180

tctggagaaa agccctatca atgtgacaaa tgtggaaagc gcttctcaca ctctgggtct     3240

tattctcaac acatgaatca tcgctactcc tactgtaaga gagaagcgga agaacgtgac     3300

agcacagagc aggaagaggc agggcctgaa atcctctcga atgagcacgt gggtgccagg     3360

gcgtctccct cacagggcga ctcggacgag agagagagtt tgacaaggga agaggatgaa     3420

gacagtgaaa aagaggaaga ggaggaggat aaagagatgg aagaattgca ggaagaaaaa     3480

gaatgtgaaa aaccacaagg ggatgaggaa gaggaggagg aggaggaaga agtggaagaa     3540

gaagaggtag aagaggcaga gaatgaggga gaagaagcaa aaactgaagg tctgatgaag     3600

gatgacaggg ctgaaagtca agcaagcagc ttaggacaaa aagtaggcga gagtagtgag     3660

caagtgtctg aagaaaagac aaatgaagcc taatcgtttt tctagaagga aaataaattc     3720

taattgataa tgaatttcgt tcaatattat ccttgctttt catggaaaca cagtaacctg     3780

tatgctgtga ttcctgttca ctactgtgta aagtaaaaac taaaaaaata caaaatacaa     3840

aacacacaca cacacacaca cacacacaca cacacacaca caaaataaat ccgggtgtgc     3900

ctgaacctca gacctagtaa tttttcatgc agttttcaaa gttaggaaca agtttgtaac     3960

atgcagcaga ttagaaaacc ttaatgactc agagagcaac aatacaagag gttaaaggaa     4020

gctgattaat tagatatgca tctggcattg ttttatctta tcagtattat cactcttatg     4080

ttggtttatt cttaagctgt acaattggga gaaattttat aattttttat tggtaaacat     4140

atgctaaatc cgcttcagta ttttattatg ttttttaaaa tgtgagaact tctgcactac     4200

aaaattccct tcacagagaa gtataatgta gttccaaccc gtgctaacta ccttttataa     4260

attcagtcta gaaggtagta atttctaata tttagatgtc ttagtagagc gtattatcat     4320

ttaaagtgta ttgttagcct taagaaagca gctgatagaa gaactgaagt ttcttactca     4380

cgtggtttaa aatggagttc aaaagattgc cattgagttc tgattgcagg gactaacaat     4440

gttaatctga taaggacagc aaaatcatca gaatcagtgt ttgtgattgt gtttgaatat     4500

gtggtaacat atgaaggata tgacatgaag ctttgtatct cctttggcct taagcaagac     4560

ctgtgtgctg taagtgccat ttctcagtat tttcaaggct ctaacccgcc ttcatccaat     4620

gtgtggccta caataactag catttgttga tttgtctctt gtatcaaaat tcccaaataa     4680

aacttaaaac cactgactct gtcagagaaa ctgaaacact gggacatttc atccttcaat     4740

tcctcggtat tgattttatg ttgattgatt ttcagaattt ctctacagaa acgaaaggga     4800

aattttctaa tctgctttat ccatgtactt gcatttcaga catggacatg ctattgttat     4860

ttggctcata actgtttcca aatgttagtt attatggacc caatttatta acaacattag     4920

ctgattttta cctatcagta ttattttatt tcttttagtt tatagatctg tgcaacattt     4980

ttgtactgta tgtcttcaaa cctggcagta ttaataccct tcttactgac atatgtactt     5040

ttagttttag aaaactttta tatttatgtg tcttattttt atatttcttt atttattaca     5100

cagtgtagtg tataatactg tagtttgtat taatacaata atatatttta gtatgaaaat     5160

ttggaaagtt gataagattt aaagtagaga tgcaattggt tctcctgcat tgagatttga     5220

tttaacagtg ttatgttaac atttatactt gccttggact gtagaacaga acttaaatgg     5280

gaatgtatta gttttacaac tacaatcaag tcattttacc tttacccagt ttttaatata     5340

aaacttaaat tttgaaattc actgtgtgac taatagcatg atgctctgca gttttattaa     5400

gaaatcagcc taaccataca actctcattt ccttagtaag ccaaattagg attaacttct     5460

ataaacagtg ttgggaacaa tgtttaacat tttgtgccaa tttgttcctg tattcatgta     5520

tgtaagttac agatctgact cttcattttt aagttccttg ttacatcatg gtcattttct     5580

agttttttac cagactccca tctcacaata aaatgcatca acaagcctga actgctgtca     5640

ttcttttcat cattatcagt attttctttg gaaaactgtg aaatggggta cattgtcatc     5700

ctgcatttga ttcatcttga gctgaatttg ggtaacacta aatgttttag acattctcca     5760

ctaaattatg gattttcttg tggctaaatg tttctggaga ggtcagagtt gacaaaacct     5820

cttcacaggt tgctccttct tcctgaaatc cttaatcctc cgcatttcat gcttcaggtc     5880

atttcaggga agcctgggtt tagatgcctt tctgactctc agctcctgca cttctgtcat     5940

catacctctg atactattat ttatattcct tccccactag gaacaggaac cacatttgtc     6000

atagtcactc tcacattcct cactgcctaa cagggtgcct ggcataagtt gggacaacag     6060

atatttgttg aataaaaata taatttgcat gtttatggag ctcagctatg ttctcacttt     6120

ttttgcttct aattccagaa tatatgttaa atgatctaat aatttgatta ttttcttata     6180

agtcttatta aacactagtc ataatagaca caataaatta tgccttcttt ttc            6233


<210> 74
<211> 906
<212> PRT
<213> Homo sapiens

<400> 74
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 75
<211> 6297
<212> DNA
<213> Homo sapiens

<400> 75
gcggaacaaa cttgtgcccg gcgctgaccg tgcaaagtgg cttccgcgcg ccgcggcccc       60

ggccggcgcc gtcgctgtcg ctcgggcccc gcgactcggg ccgggctgtg ggcgcgcggc      120

aggcgggctg cggcggcggc gggacggggc ggccgcgggt tgcgtggggt ttgtgcgcgc      180

gtgtgcgcgg gcgccggctg tgcgcgccgc gggcggacag ggttcggccg gcggcggtaa      240

agttgggacc cgcgggccgg gcgcgctcgc gtaacgggga ttagaggcgc gggggcgcgg      300

gtccctaagc gcccctcctc cctggcgcct cccgctgccc ggcccagagc cccggcctgg      360

ggactccgcg gcgagccccg cgagtggggt ccacgtttgg cggggcgcgg cggggcggcg      420

cggggaacaa ggcaggaaag ttacaaatta taatactgtg gtagaaacaa attcagattc      480

agatgatgaa gacaaactgc atattgtgga agaagaaagt gttacagatg cagctgactg      540

tgaaggtgta ccagaggatg acctgccaac agaccagaca gtgttaccag ggaggagcag      600

tgaaagagaa gggaatgcta agaactgctg ggaggatgac agaaaggaag ggcaagaaat      660

cctggggcct gaagctcagg cagatgaagc aggatgtaca gtaaaagatg atgaatgcga      720

gtcagatgca gaaaatgagc aaaaccatga tcctaatgtt gaagagtttc tacaacaaca      780

agacactgct gtcatttttc ctgaggcacc tgaagaggac cagaggcagg gcacaccaga      840

agccagtggt catgatgaaa atggaacacc agatgcattt tcacaattac tcacctgtcc      900

atattgtgat agaggctata aacgctttac ctctctgaaa gaacacatta aatatcgtca      960

tgaaaagaat gaagataact ttagttgctc cctgtgcagt tacacctttg catacagaac     1020

ccaacttgaa cgtcacatga catcacataa atcaggaaga gatcaaagac atgtgacgca     1080

gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga aaagctttca aatacaaaca     1140

tcacctaaaa gagcacttaa gaattcacag tggagagaag ccatatgaat gcccaaactg     1200

caagaaacgc ttttcccatt ctggctccta tagctcacac ataagcagta agaaatgtat     1260

cagcttgata cctgtgaatg ggcgaccaag aacaggactc aagacatctc agtgttcttc     1320

accgtctctt tcagcatcac caggcagtcc cacacgacca cagatacggc aaaagataga     1380

gaataaaccc cttcaagaac aactttctgt taaccaaatt aaaactgaac ctgtggatta     1440

tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt tcaacccctt tacaaaatgg     1500

ggttttcact ggtggtggcc cattacaggc aaccagttct cctcagggca tggtgcaagc     1560

tgttgttctg ccaacagttg gtttggtgtc tcccataagt atcaatttaa gtgatattca     1620

gaatgtactt aaagtggcgg tagatggtaa tgtaataagg caagtgttgg agaataatca     1680

agccaatctt gcatccaaag aacaagaaac aatcaatgct tcacccatac aacaaggtgg     1740

ccattctgtt atttcagcca tcagtcttcc tttggttgat caagatggaa caaccaaaat     1800

tatcatcaac tacagtcttg agcagcctag ccaacttcaa gttgttcctc aaaatttaaa     1860

aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa aagttaccag aagatcttac     1920

tgttaagtct gagaaggaca aaagctttga agggggggtg aatgatagca cttgtcttct     1980

gtgtgatgat tgtccaggag atattaatgc acttccagaa ttaaagcact atgacctaaa     2040

gcagcctact cagcctcctc cactccctgc agcagaagct gagaagcctg agtcctctgt     2100

ttcatcagct actggagatg gcaatttgtc tcctagtcag ccacctttaa agaacctctt     2160

gtctctccta aaagcatatt atgctttgaa tgcacaacca agtgcagaag agctctcaaa     2220

aattgctgat tcagtaaacc taccactgga tgtagtaaaa aagtggtttg aaaagatgca     2280

agctggacag atttcagtgc agtcttctga accatcttct cctgaaccag gcaaagtaaa     2340

tatccctgcc aagaacaatg atcagcctca atctgcaaat gcaaatgaac cccaggacag     2400

cacagtaaat ctacaaagtc ctttgaagat gactaactcc ccagttttac cagtgggatc     2460

aaccaccaat ggttccagaa gtagtacacc atccccatca cctctaaacc tttcctcatc     2520

cagaaataca cagggttact tgtacacagc tgagggtgca caagaagagc cacaagtaga     2580

acctcttgat ctttcactac caaagcaaca gggagaatta ttagaaaggt caactatcac     2640

tagtgtttac cagaacagtg tttattctgt ccaggaagaa cccttgaact tgtcttgcgc     2700

aaaaaaggag ccacaaaagg acagttgtgt tacagactca gaaccagttg taaatgtaat     2760

cccaccaagt gccaacccca taaatatcgc tatacctaca gtcactgccc agttacccac     2820

aatcgtggcc attgctgacc agaacagtgt tccatgctta agagcgctag ctgccaataa     2880

gcaaacgatt ctgattcccc aggtggcata cacctactca actacggtca gccctgcagt     2940

ccaagaacca cccttgaaag tgatccagcc aaatggaaat caggatgaaa gacaagatac     3000

tagctcagaa ggagtatcaa atgtagagga tcagaatgac tctgattcta caccgcccaa     3060

aaagaaaatg cggaagacag aaaatggaat gtatgcttgt gatttgtgtg acaagatatt     3120

ccaaaagagt agttcattat tgagacataa atatgaacac acaggtaaaa gacctcatga     3180

gtgtggaatc tgtaaaaagg catttaaaca caaacatcat ttgattgaac acatgcgatt     3240

acattctgga gaaaagccct atcaatgtga caaatgtgga aagcgcttct cacactctgg     3300

gtcttattct caacacatga atcatcgcta ctcctactgt aagagagaag cggaagaacg     3360

tgacagcaca gagcaggaag aggcagggcc tgaaatcctc tcgaatgagc acgtgggtgc     3420

cagggcgtct ccctcacagg gcgactcgga cgagagagag agtttgacaa gggaagagga     3480

tgaagacagt gaaaaagagg aagaggagga ggataaagag atggaagaat tgcaggaaga     3540

aaaagaatgt gaaaaaccac aaggggatga ggaagaggag gaggaggagg aagaagtgga     3600

agaagaagag gtagaagagg cagagaatga gggagaagaa gcaaaaactg aaggtctgat     3660

gaaggatgac agggctgaaa gtcaagcaag cagcttagga caaaaagtag gcgagagtag     3720

tgagcaagtg tctgaagaaa agacaaatga agcctaatcg tttttctaga aggaaaataa     3780

attctaattg ataatgaatt tcgttcaata ttatccttgc ttttcatgga aacacagtaa     3840

cctgtatgct gtgattcctg ttcactactg tgtaaagtaa aaactaaaaa aatacaaaat     3900

acaaaacaca cacacacaca cacacacaca cacacacaca cacacaaaat aaatccgggt     3960

gtgcctgaac ctcagaccta gtaatttttc atgcagtttt caaagttagg aacaagtttg     4020

taacatgcag cagattagaa aaccttaatg actcagagag caacaataca agaggttaaa     4080

ggaagctgat taattagata tgcatctggc attgttttat cttatcagta ttatcactct     4140

tatgttggtt tattcttaag ctgtacaatt gggagaaatt ttataatttt ttattggtaa     4200

acatatgcta aatccgcttc agtattttat tatgtttttt aaaatgtgag aacttctgca     4260

ctacaaaatt cccttcacag agaagtataa tgtagttcca acccgtgcta actacctttt     4320

ataaattcag tctagaaggt agtaatttct aatatttaga tgtcttagta gagcgtatta     4380

tcatttaaag tgtattgtta gccttaagaa agcagctgat agaagaactg aagtttctta     4440

ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga gttctgattg cagggactaa     4500

caatgttaat ctgataagga cagcaaaatc atcagaatca gtgtttgtga ttgtgtttga     4560

atatgtggta acatatgaag gatatgacat gaagctttgt atctcctttg gccttaagca     4620

agacctgtgt gctgtaagtg ccatttctca gtattttcaa ggctctaacc cgccttcatc     4680

caatgtgtgg cctacaataa ctagcatttg ttgatttgtc tcttgtatca aaattcccaa     4740

ataaaactta aaaccactga ctctgtcaga gaaactgaaa cactgggaca tttcatcctt     4800

caattcctcg gtattgattt tatgttgatt gattttcaga atttctctac agaaacgaaa     4860

gggaaatttt ctaatctgct ttatccatgt acttgcattt cagacatgga catgctattg     4920

ttatttggct cataactgtt tccaaatgtt agttattatg gacccaattt attaacaaca     4980

ttagctgatt tttacctatc agtattattt tatttctttt agtttataga tctgtgcaac     5040

atttttgtac tgtatgtctt caaacctggc agtattaata cccttcttac tgacatatgt     5100

acttttagtt ttagaaaact tttatattta tgtgtcttat ttttatattt ctttatttat     5160

tacacagtgt agtgtataat actgtagttt gtattaatac aataatatat tttagtatga     5220

aaatttggaa agttgataag atttaaagta gagatgcaat tggttctcct gcattgagat     5280

ttgatttaac agtgttatgt taacatttat acttgccttg gactgtagaa cagaacttaa     5340

atgggaatgt attagtttta caactacaat caagtcattt tacctttacc cagtttttaa     5400

tataaaactt aaattttgaa attcactgtg tgactaatag catgatgctc tgcagtttta     5460

ttaagaaatc agcctaacca tacaactctc atttccttag taagccaaat taggattaac     5520

ttctataaac agtgttggga acaatgttta acattttgtg ccaatttgtt cctgtattca     5580

tgtatgtaag ttacagatct gactcttcat ttttaagttc cttgttacat catggtcatt     5640

ttctagtttt ttaccagact cccatctcac aataaaatgc atcaacaagc ctgaactgct     5700

gtcattcttt tcatcattat cagtattttc tttggaaaac tgtgaaatgg ggtacattgt     5760

catcctgcat ttgattcatc ttgagctgaa tttgggtaac actaaatgtt ttagacattc     5820

tccactaaat tatggatttt cttgtggcta aatgtttctg gagaggtcag agttgacaaa     5880

acctcttcac aggttgctcc ttcttcctga aatccttaat cctccgcatt tcatgcttca     5940

ggtcatttca gggaagcctg ggtttagatg cctttctgac tctcagctcc tgcacttctg     6000

tcatcatacc tctgatacta ttatttatat tccttcccca ctaggaacag gaaccacatt     6060

tgtcatagtc actctcacat tcctcactgc ctaacagggt gcctggcata agttgggaca     6120

acagatattt gttgaataaa aatataattt gcatgtttat ggagctcagc tatgttctca     6180

ctttttttgc ttctaattcc agaatatatg ttaaatgatc taataatttg attattttct     6240

tataagtctt attaaacact agtcataata gacacaataa attatgcctt ctttttc        6297


<210> 76
<211> 906
<212> PRT
<213> Homo sapiens

<400> 76
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 77
<211> 6300
<212> DNA
<213> Homo sapiens

<400> 77
gcggaacaaa cttgtgcccg gcgctgaccg tgcaaagtgg cttccgcgcg ccgcggcccc       60

ggccggcgcc gtcgctgtcg ctcgggcccc gcgactcggg ccgggctgtg ggcgcgcggc      120

aggcgggctg cggcggcggc gggacggggc ggccgcgggt tgcgtggggt ttgtgcgcgc      180

gtgtgcgcgg gcgccggctg tgcgcgccgc gggcggacag ggttcggccg gcggcggtaa      240

agttgggacc cgcgggccgg gcgcgctcgc gtaacgggga ttagaggcgc gggggcgcgg      300

gtccctaagc gcccctcctc cctggcgcct cccgctgccc ggcccagagc cccggcctgg      360

ggactccgcg gcgagccccg cgagtggggt ccacgtttgg cggggcgcgg cggggcggcg      420

cggggaacaa ggcaggaaag ttacaaatta taatactgtg gtagaaacaa attcagattc      480

agatgatgaa gacaaactgc atattgtgga agaagaaagt gttacagatg cagctgactg      540

tgaaggtgta ccagaggatg acctgccaac agaccagaca gtgttaccag ggaggagcag      600

tgaaagagaa gggaatgcta agaactgctg ggaggatgac acaggaaagg aagggcaaga      660

aatcctgggg cctgaagctc aggcagatga agcaggatgt acagtaaaag atgatgaatg      720

cgagtcagat gcagaaaatg agcaaaacca tgatcctaat gttgaagagt ttctacaaca      780

acaagacact gctgtcattt ttcctgaggc acctgaagag gaccagaggc agggcacacc      840

agaagccagt ggtcatgatg aaaatggaac accagatgca ttttcacaat tactcacctg      900

tccatattgt gatagaggct ataaacgctt tacctctctg aaagaacaca ttaaatatcg      960

tcatgaaaag aatgaagata actttagttg ctccctgtgc agttacacct ttgcatacag     1020

aacccaactt gaacgtcaca tgacatcaca taaatcagga agagatcaaa gacatgtgac     1080

gcagtctggg tgtaatcgta aattcaaatg cactgagtgt ggaaaagctt tcaaatacaa     1140

acatcaccta aaagagcact taagaattca cagtggagag aagccatatg aatgcccaaa     1200

ctgcaagaaa cgcttttccc attctggctc ctatagctca cacataagca gtaagaaatg     1260

tatcagcttg atacctgtga atgggcgacc aagaacagga ctcaagacat ctcagtgttc     1320

ttcaccgtct ctttcagcat caccaggcag tcccacacga ccacagatac ggcaaaagat     1380

agagaataaa ccccttcaag aacaactttc tgttaaccaa attaaaactg aacctgtgga     1440

ttatgaattc aaacccatag tggttgcttc aggaatcaac tgttcaaccc ctttacaaaa     1500

tggggttttc actggtggtg gcccattaca ggcaaccagt tctcctcagg gcatggtgca     1560

agctgttgtt ctgccaacag ttggtttggt gtctcccata agtatcaatt taagtgatat     1620

tcagaatgta cttaaagtgg cggtagatgg taatgtaata aggcaagtgt tggagaataa     1680

tcaagccaat cttgcatcca aagaacaaga aacaatcaat gcttcaccca tacaacaagg     1740

tggccattct gttatttcag ccatcagtct tcctttggtt gatcaagatg gaacaaccaa     1800

aattatcatc aactacagtc ttgagcagcc tagccaactt caagttgttc ctcaaaattt     1860

aaaaaaagaa aatccagtcg ctacaaacag ttgtaaaagt gaaaagttac cagaagatct     1920

tactgttaag tctgagaagg acaaaagctt tgaagggggg gtgaatgata gcacttgtct     1980

tctgtgtgat gattgtccag gagatattaa tgcacttcca gaattaaagc actatgacct     2040

aaagcagcct actcagcctc ctccactccc tgcagcagaa gctgagaagc ctgagtcctc     2100

tgtttcatca gctactggag atggcaattt gtctcctagt cagccacctt taaagaacct     2160

cttgtctctc ctaaaagcat attatgcttt gaatgcacaa ccaagtgcag aagagctctc     2220

aaaaattgct gattcagtaa acctaccact ggatgtagta aaaaagtggt ttgaaaagat     2280

gcaagctgga cagatttcag tgcagtcttc tgaaccatct tctcctgaac caggcaaagt     2340

aaatatccct gccaagaaca atgatcagcc tcaatctgca aatgcaaatg aaccccagga     2400

cagcacagta aatctacaaa gtcctttgaa gatgactaac tccccagttt taccagtggg     2460

atcaaccacc aatggttcca gaagtagtac accatcccca tcacctctaa acctttcctc     2520

atccagaaat acacagggtt acttgtacac agctgagggt gcacaagaag agccacaagt     2580

agaacctctt gatctttcac taccaaagca acagggagaa ttattagaaa ggtcaactat     2640

cactagtgtt taccagaaca gtgtttattc tgtccaggaa gaacccttga acttgtcttg     2700

cgcaaaaaag gagccacaaa aggacagttg tgttacagac tcagaaccag ttgtaaatgt     2760

aatcccacca agtgccaacc ccataaatat cgctatacct acagtcactg cccagttacc     2820

cacaatcgtg gccattgctg accagaacag tgttccatgc ttaagagcgc tagctgccaa     2880

taagcaaacg attctgattc cccaggtggc atacacctac tcaactacgg tcagccctgc     2940

agtccaagaa ccacccttga aagtgatcca gccaaatgga aatcaggatg aaagacaaga     3000

tactagctca gaaggagtat caaatgtaga ggatcagaat gactctgatt ctacaccgcc     3060

caaaaagaaa atgcggaaga cagaaaatgg aatgtatgct tgtgatttgt gtgacaagat     3120

attccaaaag agtagttcat tattgagaca taaatatgaa cacacaggta aaagacctca     3180

tgagtgtgga atctgtaaaa aggcatttaa acacaaacat catttgattg aacacatgcg     3240

attacattct ggagaaaagc cctatcaatg tgacaaatgt ggaaagcgct tctcacactc     3300

tgggtcttat tctcaacaca tgaatcatcg ctactcctac tgtaagagag aagcggaaga     3360

acgtgacagc acagagcagg aagaggcagg gcctgaaatc ctctcgaatg agcacgtggg     3420

tgccagggcg tctccctcac agggcgactc ggacgagaga gagagtttga caagggaaga     3480

ggatgaagac agtgaaaaag aggaagagga ggaggataaa gagatggaag aattgcagga     3540

agaaaaagaa tgtgaaaaac cacaagggga tgaggaagag gaggaggagg aggaagaagt     3600

ggaagaagaa gaggtagaag aggcagagaa tgagggagaa gaagcaaaaa ctgaaggtct     3660

gatgaaggat gacagggctg aaagtcaagc aagcagctta ggacaaaaag taggcgagag     3720

tagtgagcaa gtgtctgaag aaaagacaaa tgaagcctaa tcgtttttct agaaggaaaa     3780

taaattctaa ttgataatga atttcgttca atattatcct tgcttttcat ggaaacacag     3840

taacctgtat gctgtgattc ctgttcacta ctgtgtaaag taaaaactaa aaaaatacaa     3900

aatacaaaac acacacacac acacacacac acacacacac acacacacaa aataaatccg     3960

ggtgtgcctg aacctcagac ctagtaattt ttcatgcagt tttcaaagtt aggaacaagt     4020

ttgtaacatg cagcagatta gaaaacctta atgactcaga gagcaacaat acaagaggtt     4080

aaaggaagct gattaattag atatgcatct ggcattgttt tatcttatca gtattatcac     4140

tcttatgttg gtttattctt aagctgtaca attgggagaa attttataat tttttattgg     4200

taaacatatg ctaaatccgc ttcagtattt tattatgttt tttaaaatgt gagaacttct     4260

gcactacaaa attcccttca cagagaagta taatgtagtt ccaacccgtg ctaactacct     4320

tttataaatt cagtctagaa ggtagtaatt tctaatattt agatgtctta gtagagcgta     4380

ttatcattta aagtgtattg ttagccttaa gaaagcagct gatagaagaa ctgaagtttc     4440

ttactcacgt ggtttaaaat ggagttcaaa agattgccat tgagttctga ttgcagggac     4500

taacaatgtt aatctgataa ggacagcaaa atcatcagaa tcagtgtttg tgattgtgtt     4560

tgaatatgtg gtaacatatg aaggatatga catgaagctt tgtatctcct ttggccttaa     4620

gcaagacctg tgtgctgtaa gtgccatttc tcagtatttt caaggctcta acccgccttc     4680

atccaatgtg tggcctacaa taactagcat ttgttgattt gtctcttgta tcaaaattcc     4740

caaataaaac ttaaaaccac tgactctgtc agagaaactg aaacactggg acatttcatc     4800

cttcaattcc tcggtattga ttttatgttg attgattttc agaatttctc tacagaaacg     4860

aaagggaaat tttctaatct gctttatcca tgtacttgca tttcagacat ggacatgcta     4920

ttgttatttg gctcataact gtttccaaat gttagttatt atggacccaa tttattaaca     4980

acattagctg atttttacct atcagtatta ttttatttct tttagtttat agatctgtgc     5040

aacatttttg tactgtatgt cttcaaacct ggcagtatta atacccttct tactgacata     5100

tgtactttta gttttagaaa acttttatat ttatgtgtct tatttttata tttctttatt     5160

tattacacag tgtagtgtat aatactgtag tttgtattaa tacaataata tattttagta     5220

tgaaaatttg gaaagttgat aagatttaaa gtagagatgc aattggttct cctgcattga     5280

gatttgattt aacagtgtta tgttaacatt tatacttgcc ttggactgta gaacagaact     5340

taaatgggaa tgtattagtt ttacaactac aatcaagtca ttttaccttt acccagtttt     5400

taatataaaa cttaaatttt gaaattcact gtgtgactaa tagcatgatg ctctgcagtt     5460

ttattaagaa atcagcctaa ccatacaact ctcatttcct tagtaagcca aattaggatt     5520

aacttctata aacagtgttg ggaacaatgt ttaacatttt gtgccaattt gttcctgtat     5580

tcatgtatgt aagttacaga tctgactctt catttttaag ttccttgtta catcatggtc     5640

attttctagt tttttaccag actcccatct cacaataaaa tgcatcaaca agcctgaact     5700

gctgtcattc ttttcatcat tatcagtatt ttctttggaa aactgtgaaa tggggtacat     5760

tgtcatcctg catttgattc atcttgagct gaatttgggt aacactaaat gttttagaca     5820

ttctccacta aattatggat tttcttgtgg ctaaatgttt ctggagaggt cagagttgac     5880

aaaacctctt cacaggttgc tccttcttcc tgaaatcctt aatcctccgc atttcatgct     5940

tcaggtcatt tcagggaagc ctgggtttag atgcctttct gactctcagc tcctgcactt     6000

ctgtcatcat acctctgata ctattattta tattccttcc ccactaggaa caggaaccac     6060

atttgtcata gtcactctca cattcctcac tgcctaacag ggtgcctggc ataagttggg     6120

acaacagata tttgttgaat aaaaatataa tttgcatgtt tatggagctc agctatgttc     6180

tcactttttt tgcttctaat tccagaatat atgttaaatg atctaataat ttgattattt     6240

tcttataagt cttattaaac actagtcata atagacacaa taaattatgc cttctttttc     6300


<210> 78
<211> 906
<212> PRT
<213> Homo sapiens

<400> 78
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 79
<211> 6139
<212> DNA
<213> Homo sapiens

<400> 79
gcggaacaaa cttgtgcccg gcgctgaccg tgcaaagtgg cttccgcgcg ccgcggcccc       60

ggccggcgcc gtcgctgtcg ctcgggcccc gcgactcggg ccgggctgtg ggcgcgcggc      120

aggcgggctg cggcggcggc gggacggggc ggccgcgggt tgcgtggggt ttgtgcgcgc      180

gtgtgcgcgg gcgccggctg tgcgcgccgc gggcggacag ggttcggccg gcggcggtaa      240

agttgggacc cgcgggccgg gcgcgctcgc gtaacgggga ttagaggcgc gggggcgcgg      300

gtccctaagc gcccctcctc cctggcgcct cccgctgccc ggcccagagc cccggcctgg      360

ggactccgcg gcgagccccg cgagtggggt ccacgtttgg cggggcgcgg cggggcggcg      420

cggggaacaa ggcaggaaag cagctgttta aggaagacag agcaggcatt ggataatatt      480

cttattaagg aaaggaaggg caagaaatcc tggggcctga agctcaggca gatgaagcag      540

gatgtacaga tgatgaatgc gagtcagatg cagaaaatga gcaaaaccat gatcctaatg      600

ttgaagagtt tctacaacaa caagacactg ctgtcatttt tcctgaggca cctgaagagg      660

accagaggca gggcacacca gaagccagtg gtcatgatga aaatggaaca ccagatgcat      720

tttcacaatt actcacctgt ccatattgtg atagaggcta taaacgcttt acctctctga      780

aagaacacat taaatatcgt catgaaaaga atgaagataa ctttagttgc tccctgtgca      840

gttacacctt tgcatacaga acccaacttg aacgtcacat gacatcacat aaatcaggaa      900

gagatcaaag acatgtgacg cagtctgggt gtaatcgtaa attcaaatgc actgagtgtg      960

gaaaagcttt caaatacaaa catcacctaa aagagcactt aagaattcac agtggagaga     1020

agccatatga atgcccaaac tgcaagaaac gcttttccca ttctggctcc tatagctcac     1080

acataagcag taagaaatgt atcagcttga tacctgtgaa tgggcgacca agaacaggac     1140

tcaagacatc tcagtgttct tcaccgtctc tttcagcatc accaggcagt cccacacgac     1200

cacagatacg gcaaaagata gagaataaac cccttcaaga acaactttct gttaaccaaa     1260

ttaaaactga acctgtggat tatgaattca aacccatagt ggttgcttca ggaatcaact     1320

gttcaacccc tttacaaaat ggggttttca ctggtggtgg cccattacag gcaaccagtt     1380

ctcctcaggg catggtgcaa gctgttgttc tgccaacagt tggtttggtg tctcccataa     1440

gtatcaattt aagtgatatt cagaatgtac ttaaagtggc ggtagatggt aatgtaataa     1500

ggcaagtgtt ggagaataat caagccaatc ttgcatccaa agaacaagaa acaatcaatg     1560

cttcacccat acaacaaggt ggccattctg ttatttcagc catcagtctt cctttggttg     1620

atcaagatgg aacaaccaaa attatcatca actacagtct tgagcagcct agccaacttc     1680

aagttgttcc tcaaaattta aaaaaagaaa atccagtcgc tacaaacagt tgtaaaagtg     1740

aaaagttacc agaagatctt actgttaagt ctgagaagga caaaagcttt gaaggggggg     1800

tgaatgatag cacttgtctt ctgtgtgatg attgtccagg agatattaat gcacttccag     1860

aattaaagca ctatgaccta aagcagccta ctcagcctcc tccactccct gcagcagaag     1920

ctgagaagcc tgagtcctct gtttcatcag ctactggaga tggcaatttg tctcctagtc     1980

agccaccttt aaagaacctc ttgtctctcc taaaagcata ttatgctttg aatgcacaac     2040

caagtgcaga agagctctca aaaattgctg attcagtaaa cctaccactg gatgtagtaa     2100

aaaagtggtt tgaaaagatg caagctggac agatttcagt gcagtcttct gaaccatctt     2160

ctcctgaacc aggcaaagta aatatccctg ccaagaacaa tgatcagcct caatctgcaa     2220

atgcaaatga accccaggac agcacagtaa atctacaaag tcctttgaag atgactaact     2280

ccccagtttt accagtggga tcaaccacca atggttccag aagtagtaca ccatccccat     2340

cacctctaaa cctttcctca tccagaaata cacagggtta cttgtacaca gctgagggtg     2400

cacaagaaga gccacaagta gaacctcttg atctttcact accaaagcaa cagggagaat     2460

tattagaaag gtcaactatc actagtgttt accagaacag tgtttattct gtccaggaag     2520

aacccttgaa cttgtcttgc gcaaaaaagg agccacaaaa ggacagttgt gttacagact     2580

cagaaccagt tgtaaatgta atcccaccaa gtgccaaccc cataaatatc gctataccta     2640

cagtcactgc ccagttaccc acaatcgtgg ccattgctga ccagaacagt gttccatgct     2700

taagagcgct agctgccaat aagcaaacga ttctgattcc ccaggtggca tacacctact     2760

caactacggt cagccctgca gtccaagaac cacccttgaa agtgatccag ccaaatggaa     2820

atcaggatga aagacaagat actagctcag aaggagtatc aaatgtagag gatcagaatg     2880

actctgattc tacaccgccc aaaaagaaaa tgcggaagac agaaaatgga atgtatgctt     2940

gtgatttgtg tgacaagata ttccaaaaga gtagttcatt attgagacat aaatatgaac     3000

acacaggtaa aagacctcat gagtgtggaa tctgtaaaaa ggcatttaaa cacaaacatc     3060

atttgattga acacatgcga ttacattctg gagaaaagcc ctatcaatgt gacaaatgtg     3120

gaaagcgctt ctcacactct gggtcttatt ctcaacacat gaatcatcgc tactcctact     3180

gtaagagaga agcggaagaa cgtgacagca cagagcagga agaggcaggg cctgaaatcc     3240

tctcgaatga gcacgtgggt gccagggcgt ctccctcaca gggcgactcg gacgagagag     3300

agagtttgac aagggaagag gatgaagaca gtgaaaaaga ggaagaggag gaggataaag     3360

agatggaaga attgcaggaa gaaaaagaat gtgaaaaacc acaaggggat gaggaagagg     3420

aggaggagga ggaagaagtg gaagaagaag aggtagaaga ggcagagaat gagggagaag     3480

aagcaaaaac tgaaggtctg atgaaggatg acagggctga aagtcaagca agcagcttag     3540

gacaaaaagt aggcgagagt agtgagcaag tgtctgaaga aaagacaaat gaagcctaat     3600

cgtttttcta gaaggaaaat aaattctaat tgataatgaa tttcgttcaa tattatcctt     3660

gcttttcatg gaaacacagt aacctgtatg ctgtgattcc tgttcactac tgtgtaaagt     3720

aaaaactaaa aaaatacaaa atacaaaaca cacacacaca cacacacaca cacacacaca     3780

cacacacaaa ataaatccgg gtgtgcctga acctcagacc tagtaatttt tcatgcagtt     3840

ttcaaagtta ggaacaagtt tgtaacatgc agcagattag aaaaccttaa tgactcagag     3900

agcaacaata caagaggtta aaggaagctg attaattaga tatgcatctg gcattgtttt     3960

atcttatcag tattatcact cttatgttgg tttattctta agctgtacaa ttgggagaaa     4020

ttttataatt ttttattggt aaacatatgc taaatccgct tcagtatttt attatgtttt     4080

ttaaaatgtg agaacttctg cactacaaaa ttcccttcac agagaagtat aatgtagttc     4140

caacccgtgc taactacctt ttataaattc agtctagaag gtagtaattt ctaatattta     4200

gatgtcttag tagagcgtat tatcatttaa agtgtattgt tagccttaag aaagcagctg     4260

atagaagaac tgaagtttct tactcacgtg gtttaaaatg gagttcaaaa gattgccatt     4320

gagttctgat tgcagggact aacaatgtta atctgataag gacagcaaaa tcatcagaat     4380

cagtgtttgt gattgtgttt gaatatgtgg taacatatga aggatatgac atgaagcttt     4440

gtatctcctt tggccttaag caagacctgt gtgctgtaag tgccatttct cagtattttc     4500

aaggctctaa cccgccttca tccaatgtgt ggcctacaat aactagcatt tgttgatttg     4560

tctcttgtat caaaattccc aaataaaact taaaaccact gactctgtca gagaaactga     4620

aacactggga catttcatcc ttcaattcct cggtattgat tttatgttga ttgattttca     4680

gaatttctct acagaaacga aagggaaatt ttctaatctg ctttatccat gtacttgcat     4740

ttcagacatg gacatgctat tgttatttgg ctcataactg tttccaaatg ttagttatta     4800

tggacccaat ttattaacaa cattagctga tttttaccta tcagtattat tttatttctt     4860

ttagtttata gatctgtgca acatttttgt actgtatgtc ttcaaacctg gcagtattaa     4920

tacccttctt actgacatat gtacttttag ttttagaaaa cttttatatt tatgtgtctt     4980

atttttatat ttctttattt attacacagt gtagtgtata atactgtagt ttgtattaat     5040

acaataatat attttagtat gaaaatttgg aaagttgata agatttaaag tagagatgca     5100

attggttctc ctgcattgag atttgattta acagtgttat gttaacattt atacttgcct     5160

tggactgtag aacagaactt aaatgggaat gtattagttt tacaactaca atcaagtcat     5220

tttaccttta cccagttttt aatataaaac ttaaattttg aaattcactg tgtgactaat     5280

agcatgatgc tctgcagttt tattaagaaa tcagcctaac catacaactc tcatttcctt     5340

agtaagccaa attaggatta acttctataa acagtgttgg gaacaatgtt taacattttg     5400

tgccaatttg ttcctgtatt catgtatgta agttacagat ctgactcttc atttttaagt     5460

tccttgttac atcatggtca ttttctagtt ttttaccaga ctcccatctc acaataaaat     5520

gcatcaacaa gcctgaactg ctgtcattct tttcatcatt atcagtattt tctttggaaa     5580

actgtgaaat ggggtacatt gtcatcctgc atttgattca tcttgagctg aatttgggta     5640

acactaaatg ttttagacat tctccactaa attatggatt ttcttgtggc taaatgtttc     5700

tggagaggtc agagttgaca aaacctcttc acaggttgct ccttcttcct gaaatcctta     5760

atcctccgca tttcatgctt caggtcattt cagggaagcc tgggtttaga tgcctttctg     5820

actctcagct cctgcacttc tgtcatcata cctctgatac tattatttat attccttccc     5880

cactaggaac aggaaccaca tttgtcatag tcactctcac attcctcact gcctaacagg     5940

gtgcctggca taagttggga caacagatat ttgttgaata aaaatataat ttgcatgttt     6000

atggagctca gctatgttct cacttttttt gcttctaatt ccagaatata tgttaaatga     6060

tctaataatt tgattatttt cttataagtc ttattaaaca ctagtcataa tagacacaat     6120

aaattatgcc ttctttttc                                                  6139


<210> 80
<211> 906
<212> PRT
<213> Homo sapiens

<400> 80
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 81
<211> 6005
<212> DNA
<213> Homo sapiens

<400> 81
attgatttgt gctgctgtgc caagggaaac acacacccct ctgcctggcg tgagagttaa       60

aaaaaaagag agacagcccg agggatcgag acctgaacat gtggtggtgg ttgcacagtc      120

gccttttcca gtttggagag acgttttaca aattataata ctgtggtaga aacaaattca      180

gattcagatg atgaagacaa actgcatatt gtggaagaag aaagtgttac agatgcagct      240

gactgtgaag gtgtaccaga ggatgacctg ccaacagacc agacagtgtt accagggagg      300

agcagtgaaa gagaagggaa tgctaagaac tgctgggagg atgacacagg aaaggaaggg      360

caagaaatcc tggggcctga agctcaggca gatgaagcag gatgtacagt aaaagatgat      420

gaatgcgagt cagatgcaga aaatgagcaa aaccatgatc ctaatgttga agagtttcta      480

caacaacaag acactgctgt catttttcct gaggcacctg aagaggacca gaggcagggc      540

acaccagaag ccagtggtca tgatgaaaat ggaacaccag atgcattttc acaattactc      600

acctgtccat attgtgatag aggctataaa cgctttacct ctctgaaaga acacattaaa      660

tatcgtcatg aaaagaatga agataacttt agttgctccc tgtgcagtta cacctttgca      720

tacagaaccc aacttgaacg tcacatgaca tcacataaat caggaagaga tcaaagacat      780

gtgacgcagt ctgggtgtaa tcgtaaattc aaatgcactg agtgtggaaa agctttcaaa      840

tacaaacatc acctaaaaga gcacttaaga attcacagtg gagagaagcc atatgaatgc      900

ccaaactgca agaaacgctt ttcccattct ggctcctata gctcacacat aagcagtaag      960

aaatgtatca gcttgatacc tgtgaatggg cgaccaagaa caggactcaa gacatctcag     1020

tgttcttcac cgtctctttc agcatcacca ggcagtccca cacgaccaca gatacggcaa     1080

aagatagaga ataaacccct tcaagaacaa ctttctgtta accaaattaa aactgaacct     1140

gtggattatg aattcaaacc catagtggtt gcttcaggaa tcaactgttc aaccccttta     1200

caaaatgggg ttttcactgg tggtggccca ttacaggcaa ccagttctcc tcagggcatg     1260

gtgcaagctg ttgttctgcc aacagttggt ttggtgtctc ccataagtat caatttaagt     1320

gatattcaga atgtacttaa agtggcggta gatggtaatg taataaggca agtgttggag     1380

aataatcaag ccaatcttgc atccaaagaa caagaaacaa tcaatgcttc acccatacaa     1440

caaggtggcc attctgttat ttcagccatc agtcttcctt tggttgatca agatggaaca     1500

accaaaatta tcatcaacta cagtcttgag cagcctagcc aacttcaagt tgttcctcaa     1560

aatttaaaaa aagaaaatcc agtcgctaca aacagttgta aaagtgaaaa gttaccagaa     1620

gatcttactg ttaagtctga gaaggacaaa agctttgaag ggggggtgaa tgatagcact     1680

tgtcttctgt gtgatgattg tccaggagat attaatgcac ttccagaatt aaagcactat     1740

gacctaaagc agcctactca gcctcctcca ctccctgcag cagaagctga gaagcctgag     1800

tcctctgttt catcagctac tggagatggc aatttgtctc ctagtcagcc acctttaaag     1860

aacctcttgt ctctcctaaa agcatattat gctttgaatg cacaaccaag tgcagaagag     1920

ctctcaaaaa ttgctgattc agtaaaccta ccactggatg tagtaaaaaa gtggtttgaa     1980

aagatgcaag ctggacagat ttcagtgcag tcttctgaac catcttctcc tgaaccaggc     2040

aaagtaaata tccctgccaa gaacaatgat cagcctcaat ctgcaaatgc aaatgaaccc     2100

caggacagca cagtaaatct acaaagtcct ttgaagatga ctaactcccc agttttacca     2160

gtgggatcaa ccaccaatgg ttccagaagt agtacaccat ccccatcacc tctaaacctt     2220

tcctcatcca gaaatacaca gggttacttg tacacagctg agggtgcaca agaagagcca     2280

caagtagaac ctcttgatct ttcactacca aagcaacagg gagaattatt agaaaggtca     2340

actatcacta gtgtttacca gaacagtgtt tattctgtcc aggaagaacc cttgaacttg     2400

tcttgcgcaa aaaaggagcc acaaaaggac agttgtgtta cagactcaga accagttgta     2460

aatgtaatcc caccaagtgc caaccccata aatatcgcta tacctacagt cactgcccag     2520

ttacccacaa tcgtggccat tgctgaccag aacagtgttc catgcttaag agcgctagct     2580

gccaataagc aaacgattct gattccccag gtggcataca cctactcaac tacggtcagc     2640

cctgcagtcc aagaaccacc cttgaaagtg atccagccaa atggaaatca ggatgaaaga     2700

caagatacta gctcagaagg agtatcaaat gtagaggatc agaatgactc tgattctaca     2760

ccgcccaaaa agaaaatgcg gaagacagaa aatggaatgt atgcttgtga tttgtgtgac     2820

aagatattcc aaaagagtag ttcattattg agacataaat atgaacacac aggtaaaaga     2880

cctcatgagt gtggaatctg taaaaaggca tttaaacaca aacatcattt gattgaacac     2940

atgcgattac attctggaga aaagccctat caatgtgaca aatgtggaaa gcgcttctca     3000

cactctgggt cttattctca acacatgaat catcgctact cctactgtaa gagagaagcg     3060

gaagaacgtg acagcacaga gcaggaagag gcagggcctg aaatcctctc gaatgagcac     3120

gtgggtgcca gggcgtctcc ctcacagggc gactcggacg agagagagag tttgacaagg     3180

gaagaggatg aagacagtga aaaagaggaa gaggaggagg ataaagagat ggaagaattg     3240

caggaagaaa aagaatgtga aaaaccacaa ggggatgagg aagaggagga ggaggaggaa     3300

gaagtggaag aagaagaggt agaagaggca gagaatgagg gagaagaagc aaaaactgaa     3360

ggtctgatga aggatgacag ggctgaaagt caagcaagca gcttaggaca aaaagtaggc     3420

gagagtagtg agcaagtgtc tgaagaaaag acaaatgaag cctaatcgtt tttctagaag     3480

gaaaataaat tctaattgat aatgaatttc gttcaatatt atccttgctt ttcatggaaa     3540

cacagtaacc tgtatgctgt gattcctgtt cactactgtg taaagtaaaa actaaaaaaa     3600

tacaaaatac aaaacacaca cacacacaca cacacacaca cacacacaca cacaaaataa     3660

atccgggtgt gcctgaacct cagacctagt aatttttcat gcagttttca aagttaggaa     3720

caagtttgta acatgcagca gattagaaaa ccttaatgac tcagagagca acaatacaag     3780

aggttaaagg aagctgatta attagatatg catctggcat tgttttatct tatcagtatt     3840

atcactctta tgttggttta ttcttaagct gtacaattgg gagaaatttt ataatttttt     3900

attggtaaac atatgctaaa tccgcttcag tattttatta tgttttttaa aatgtgagaa     3960

cttctgcact acaaaattcc cttcacagag aagtataatg tagttccaac ccgtgctaac     4020

taccttttat aaattcagtc tagaaggtag taatttctaa tatttagatg tcttagtaga     4080

gcgtattatc atttaaagtg tattgttagc cttaagaaag cagctgatag aagaactgaa     4140

gtttcttact cacgtggttt aaaatggagt tcaaaagatt gccattgagt tctgattgca     4200

gggactaaca atgttaatct gataaggaca gcaaaatcat cagaatcagt gtttgtgatt     4260

gtgtttgaat atgtggtaac atatgaagga tatgacatga agctttgtat ctcctttggc     4320

cttaagcaag acctgtgtgc tgtaagtgcc atttctcagt attttcaagg ctctaacccg     4380

ccttcatcca atgtgtggcc tacaataact agcatttgtt gatttgtctc ttgtatcaaa     4440

attcccaaat aaaacttaaa accactgact ctgtcagaga aactgaaaca ctgggacatt     4500

tcatccttca attcctcggt attgatttta tgttgattga ttttcagaat ttctctacag     4560

aaacgaaagg gaaattttct aatctgcttt atccatgtac ttgcatttca gacatggaca     4620

tgctattgtt atttggctca taactgtttc caaatgttag ttattatgga cccaatttat     4680

taacaacatt agctgatttt tacctatcag tattatttta tttcttttag tttatagatc     4740

tgtgcaacat ttttgtactg tatgtcttca aacctggcag tattaatacc cttcttactg     4800

acatatgtac ttttagtttt agaaaacttt tatatttatg tgtcttattt ttatatttct     4860

ttatttatta cacagtgtag tgtataatac tgtagtttgt attaatacaa taatatattt     4920

tagtatgaaa atttggaaag ttgataagat ttaaagtaga gatgcaattg gttctcctgc     4980

attgagattt gatttaacag tgttatgtta acatttatac ttgccttgga ctgtagaaca     5040

gaacttaaat gggaatgtat tagttttaca actacaatca agtcatttta cctttaccca     5100

gtttttaata taaaacttaa attttgaaat tcactgtgtg actaatagca tgatgctctg     5160

cagttttatt aagaaatcag cctaaccata caactctcat ttccttagta agccaaatta     5220

ggattaactt ctataaacag tgttgggaac aatgtttaac attttgtgcc aatttgttcc     5280

tgtattcatg tatgtaagtt acagatctga ctcttcattt ttaagttcct tgttacatca     5340

tggtcatttt ctagtttttt accagactcc catctcacaa taaaatgcat caacaagcct     5400

gaactgctgt cattcttttc atcattatca gtattttctt tggaaaactg tgaaatgggg     5460

tacattgtca tcctgcattt gattcatctt gagctgaatt tgggtaacac taaatgtttt     5520

agacattctc cactaaatta tggattttct tgtggctaaa tgtttctgga gaggtcagag     5580

ttgacaaaac ctcttcacag gttgctcctt cttcctgaaa tccttaatcc tccgcatttc     5640

atgcttcagg tcatttcagg gaagcctggg tttagatgcc tttctgactc tcagctcctg     5700

cacttctgtc atcatacctc tgatactatt atttatattc cttccccact aggaacagga     5760

accacatttg tcatagtcac tctcacattc ctcactgcct aacagggtgc ctggcataag     5820

ttgggacaac agatatttgt tgaataaaaa tataatttgc atgtttatgg agctcagcta     5880

tgttctcact ttttttgctt ctaattccag aatatatgtt aaatgatcta ataatttgat     5940

tattttctta taagtcttat taaacactag tcataataga cacaataaat tatgccttct     6000

ttttc                                                                 6005


<210> 82
<211> 906
<212> PRT
<213> Homo sapiens

<400> 82
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 83
<211> 6002
<212> DNA
<213> Homo sapiens

<400> 83
attgatttgt gctgctgtgc caagggaaac acacacccct ctgcctggcg tgagagttaa       60

aaaaaaagag agacagcccg agggatcgag acctgaacat gtggtggtgg ttgcacagtc      120

gccttttcca gtttggagag acgttttaca aattataata ctgtggtaga aacaaattca      180

gattcagatg atgaagacaa actgcatatt gtggaagaag aaagtgttac agatgcagct      240

gactgtgaag gtgtaccaga ggatgacctg ccaacagacc agacagtgtt accagggagg      300

agcagtgaaa gagaagggaa tgctaagaac tgctgggagg atgacagaaa ggaagggcaa      360

gaaatcctgg ggcctgaagc tcaggcagat gaagcaggat gtacagtaaa agatgatgaa      420

tgcgagtcag atgcagaaaa tgagcaaaac catgatccta atgttgaaga gtttctacaa      480

caacaagaca ctgctgtcat ttttcctgag gcacctgaag aggaccagag gcagggcaca      540

ccagaagcca gtggtcatga tgaaaatgga acaccagatg cattttcaca attactcacc      600

tgtccatatt gtgatagagg ctataaacgc tttacctctc tgaaagaaca cattaaatat      660

cgtcatgaaa agaatgaaga taactttagt tgctccctgt gcagttacac ctttgcatac      720

agaacccaac ttgaacgtca catgacatca cataaatcag gaagagatca aagacatgtg      780

acgcagtctg ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc tttcaaatac      840

aaacatcacc taaaagagca cttaagaatt cacagtggag agaagccata tgaatgccca      900

aactgcaaga aacgcttttc ccattctggc tcctatagct cacacataag cagtaagaaa      960

tgtatcagct tgatacctgt gaatgggcga ccaagaacag gactcaagac atctcagtgt     1020

tcttcaccgt ctctttcagc atcaccaggc agtcccacac gaccacagat acggcaaaag     1080

atagagaata aaccccttca agaacaactt tctgttaacc aaattaaaac tgaacctgtg     1140

gattatgaat tcaaacccat agtggttgct tcaggaatca actgttcaac ccctttacaa     1200

aatggggttt tcactggtgg tggcccatta caggcaacca gttctcctca gggcatggtg     1260

caagctgttg ttctgccaac agttggtttg gtgtctccca taagtatcaa tttaagtgat     1320

attcagaatg tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt gttggagaat     1380

aatcaagcca atcttgcatc caaagaacaa gaaacaatca atgcttcacc catacaacaa     1440

ggtggccatt ctgttatttc agccatcagt cttcctttgg ttgatcaaga tggaacaacc     1500

aaaattatca tcaactacag tcttgagcag cctagccaac ttcaagttgt tcctcaaaat     1560

ttaaaaaaag aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt accagaagat     1620

cttactgtta agtctgagaa ggacaaaagc tttgaagggg gggtgaatga tagcacttgt     1680

cttctgtgtg atgattgtcc aggagatatt aatgcacttc cagaattaaa gcactatgac     1740

ctaaagcagc ctactcagcc tcctccactc cctgcagcag aagctgagaa gcctgagtcc     1800

tctgtttcat cagctactgg agatggcaat ttgtctccta gtcagccacc tttaaagaac     1860

ctcttgtctc tcctaaaagc atattatgct ttgaatgcac aaccaagtgc agaagagctc     1920

tcaaaaattg ctgattcagt aaacctacca ctggatgtag taaaaaagtg gtttgaaaag     1980

atgcaagctg gacagatttc agtgcagtct tctgaaccat cttctcctga accaggcaaa     2040

gtaaatatcc ctgccaagaa caatgatcag cctcaatctg caaatgcaaa tgaaccccag     2100

gacagcacag taaatctaca aagtcctttg aagatgacta actccccagt tttaccagtg     2160

ggatcaacca ccaatggttc cagaagtagt acaccatccc catcacctct aaacctttcc     2220

tcatccagaa atacacaggg ttacttgtac acagctgagg gtgcacaaga agagccacaa     2280

gtagaacctc ttgatctttc actaccaaag caacagggag aattattaga aaggtcaact     2340

atcactagtg tttaccagaa cagtgtttat tctgtccagg aagaaccctt gaacttgtct     2400

tgcgcaaaaa aggagccaca aaaggacagt tgtgttacag actcagaacc agttgtaaat     2460

gtaatcccac caagtgccaa ccccataaat atcgctatac ctacagtcac tgcccagtta     2520

cccacaatcg tggccattgc tgaccagaac agtgttccat gcttaagagc gctagctgcc     2580

aataagcaaa cgattctgat tccccaggtg gcatacacct actcaactac ggtcagccct     2640

gcagtccaag aaccaccctt gaaagtgatc cagccaaatg gaaatcagga tgaaagacaa     2700

gatactagct cagaaggagt atcaaatgta gaggatcaga atgactctga ttctacaccg     2760

cccaaaaaga aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt gtgtgacaag     2820

atattccaaa agagtagttc attattgaga cataaatatg aacacacagg taaaagacct     2880

catgagtgtg gaatctgtaa aaaggcattt aaacacaaac atcatttgat tgaacacatg     2940

cgattacatt ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg cttctcacac     3000

tctgggtctt attctcaaca catgaatcat cgctactcct actgtaagag agaagcggaa     3060

gaacgtgaca gcacagagca ggaagaggca gggcctgaaa tcctctcgaa tgagcacgtg     3120

ggtgccaggg cgtctccctc acagggcgac tcggacgaga gagagagttt gacaagggaa     3180

gaggatgaag acagtgaaaa agaggaagag gaggaggata aagagatgga agaattgcag     3240

gaagaaaaag aatgtgaaaa accacaaggg gatgaggaag aggaggagga ggaggaagaa     3300

gtggaagaag aagaggtaga agaggcagag aatgagggag aagaagcaaa aactgaaggt     3360

ctgatgaagg atgacagggc tgaaagtcaa gcaagcagct taggacaaaa agtaggcgag     3420

agtagtgagc aagtgtctga agaaaagaca aatgaagcct aatcgttttt ctagaaggaa     3480

aataaattct aattgataat gaatttcgtt caatattatc cttgcttttc atggaaacac     3540

agtaacctgt atgctgtgat tcctgttcac tactgtgtaa agtaaaaact aaaaaaatac     3600

aaaatacaaa acacacacac acacacacac acacacacac acacacacac aaaataaatc     3660

cgggtgtgcc tgaacctcag acctagtaat ttttcatgca gttttcaaag ttaggaacaa     3720

gtttgtaaca tgcagcagat tagaaaacct taatgactca gagagcaaca atacaagagg     3780

ttaaaggaag ctgattaatt agatatgcat ctggcattgt tttatcttat cagtattatc     3840

actcttatgt tggtttattc ttaagctgta caattgggag aaattttata attttttatt     3900

ggtaaacata tgctaaatcc gcttcagtat tttattatgt tttttaaaat gtgagaactt     3960

ctgcactaca aaattccctt cacagagaag tataatgtag ttccaacccg tgctaactac     4020

cttttataaa ttcagtctag aaggtagtaa tttctaatat ttagatgtct tagtagagcg     4080

tattatcatt taaagtgtat tgttagcctt aagaaagcag ctgatagaag aactgaagtt     4140

tcttactcac gtggtttaaa atggagttca aaagattgcc attgagttct gattgcaggg     4200

actaacaatg ttaatctgat aaggacagca aaatcatcag aatcagtgtt tgtgattgtg     4260

tttgaatatg tggtaacata tgaaggatat gacatgaagc tttgtatctc ctttggcctt     4320

aagcaagacc tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc taacccgcct     4380

tcatccaatg tgtggcctac aataactagc atttgttgat ttgtctcttg tatcaaaatt     4440

cccaaataaa acttaaaacc actgactctg tcagagaaac tgaaacactg ggacatttca     4500

tccttcaatt cctcggtatt gattttatgt tgattgattt tcagaatttc tctacagaaa     4560

cgaaagggaa attttctaat ctgctttatc catgtacttg catttcagac atggacatgc     4620

tattgttatt tggctcataa ctgtttccaa atgttagtta ttatggaccc aatttattaa     4680

caacattagc tgatttttac ctatcagtat tattttattt cttttagttt atagatctgt     4740

gcaacatttt tgtactgtat gtcttcaaac ctggcagtat taataccctt cttactgaca     4800

tatgtacttt tagttttaga aaacttttat atttatgtgt cttattttta tatttcttta     4860

tttattacac agtgtagtgt ataatactgt agtttgtatt aatacaataa tatattttag     4920

tatgaaaatt tggaaagttg ataagattta aagtagagat gcaattggtt ctcctgcatt     4980

gagatttgat ttaacagtgt tatgttaaca tttatacttg ccttggactg tagaacagaa     5040

cttaaatggg aatgtattag ttttacaact acaatcaagt cattttacct ttacccagtt     5100

tttaatataa aacttaaatt ttgaaattca ctgtgtgact aatagcatga tgctctgcag     5160

ttttattaag aaatcagcct aaccatacaa ctctcatttc cttagtaagc caaattagga     5220

ttaacttcta taaacagtgt tgggaacaat gtttaacatt ttgtgccaat ttgttcctgt     5280

attcatgtat gtaagttaca gatctgactc ttcattttta agttccttgt tacatcatgg     5340

tcattttcta gttttttacc agactcccat ctcacaataa aatgcatcaa caagcctgaa     5400

ctgctgtcat tcttttcatc attatcagta ttttctttgg aaaactgtga aatggggtac     5460

attgtcatcc tgcatttgat tcatcttgag ctgaatttgg gtaacactaa atgttttaga     5520

cattctccac taaattatgg attttcttgt ggctaaatgt ttctggagag gtcagagttg     5580

acaaaacctc ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc gcatttcatg     5640

cttcaggtca tttcagggaa gcctgggttt agatgccttt ctgactctca gctcctgcac     5700

ttctgtcatc atacctctga tactattatt tatattcctt ccccactagg aacaggaacc     5760

acatttgtca tagtcactct cacattcctc actgcctaac agggtgcctg gcataagttg     5820

ggacaacaga tatttgttga ataaaaatat aatttgcatg tttatggagc tcagctatgt     5880

tctcactttt tttgcttcta attccagaat atatgttaaa tgatctaata atttgattat     5940

tttcttataa gtcttattaa acactagtca taatagacac aataaattat gccttctttt     6000

tc                                                                    6002


<210> 84
<211> 906
<212> PRT
<213> Homo sapiens

<400> 84
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 85
<211> 6148
<212> DNA
<213> Homo sapiens

<400> 85
attgatttgt gctgctgtgc caagggaaac acacacccct ctgcctggcg tgagagttaa       60

aaaaaaagag agacagcccg agggatcgag acctgaacat gtggtggtgg ttgcacagtc      120

gccttttcca gtttggagag acgttgacaa ccttaaactt ccaccacaag aggaatataa      180

agaggtccct cctgcaccaa gaaagatctg cagatctttt tcagtgttct tggaggtgtg      240

gggtgtgaga acttgatcag tttgtgtcag ccaccttgtt ctctaaagtt acaaattata      300

atactgtggt agaaacaaat tcagattcag atgatgaaga caaactgcat attgtggaag      360

aagaaagtgt tacagatgca gctgactgtg aaggtgtacc agaggatgac ctgccaacag      420

accagacagt gttaccaggg aggagcagtg aaagagaagg gaatgctaag aactgctggg      480

aggatgacac aggaaaggaa gggcaagaaa tcctggggcc tgaagctcag gcagatgaag      540

caggatgtac agtaaaagat gatgaatgcg agtcagatgc agaaaatgag caaaaccatg      600

atcctaatgt tgaagagttt ctacaacaac aagacactgc tgtcattttt cctgaggcac      660

ctgaagagga ccagaggcag ggcacaccag aagccagtgg tcatgatgaa aatggaacac      720

cagatgcatt ttcacaatta ctcacctgtc catattgtga tagaggctat aaacgcttta      780

cctctctgaa agaacacatt aaatatcgtc atgaaaagaa tgaagataac tttagttgct      840

ccctgtgcag ttacaccttt gcatacagaa cccaacttga acgtcacatg acatcacata      900

aatcaggaag agatcaaaga catgtgacgc agtctgggtg taatcgtaaa ttcaaatgca      960

ctgagtgtgg aaaagctttc aaatacaaac atcacctaaa agagcactta agaattcaca     1020

gtggagagaa gccatatgaa tgcccaaact gcaagaaacg cttttcccat tctggctcct     1080

atagctcaca cataagcagt aagaaatgta tcagcttgat acctgtgaat gggcgaccaa     1140

gaacaggact caagacatct cagtgttctt caccgtctct ttcagcatca ccaggcagtc     1200

ccacacgacc acagatacgg caaaagatag agaataaacc ccttcaagaa caactttctg     1260

ttaaccaaat taaaactgaa cctgtggatt atgaattcaa acccatagtg gttgcttcag     1320

gaatcaactg ttcaacccct ttacaaaatg gggttttcac tggtggtggc ccattacagg     1380

caaccagttc tcctcagggc atggtgcaag ctgttgttct gccaacagtt ggtttggtgt     1440

ctcccataag tatcaattta agtgatattc agaatgtact taaagtggcg gtagatggta     1500

atgtaataag gcaagtgttg gagaataatc aagccaatct tgcatccaaa gaacaagaaa     1560

caatcaatgc ttcacccata caacaaggtg gccattctgt tatttcagcc atcagtcttc     1620

ctttggttga tcaagatgga acaaccaaaa ttatcatcaa ctacagtctt gagcagccta     1680

gccaacttca agttgttcct caaaatttaa aaaaagaaaa tccagtcgct acaaacagtt     1740

gtaaaagtga aaagttacca gaagatctta ctgttaagtc tgagaaggac aaaagctttg     1800

aagggggggt gaatgatagc acttgtcttc tgtgtgatga ttgtccagga gatattaatg     1860

cacttccaga attaaagcac tatgacctaa agcagcctac tcagcctcct ccactccctg     1920

cagcagaagc tgagaagcct gagtcctctg tttcatcagc tactggagat ggcaatttgt     1980

ctcctagtca gccaccttta aagaacctct tgtctctcct aaaagcatat tatgctttga     2040

atgcacaacc aagtgcagaa gagctctcaa aaattgctga ttcagtaaac ctaccactgg     2100

atgtagtaaa aaagtggttt gaaaagatgc aagctggaca gatttcagtg cagtcttctg     2160

aaccatcttc tcctgaacca ggcaaagtaa atatccctgc caagaacaat gatcagcctc     2220

aatctgcaaa tgcaaatgaa ccccaggaca gcacagtaaa tctacaaagt cctttgaaga     2280

tgactaactc cccagtttta ccagtgggat caaccaccaa tggttccaga agtagtacac     2340

catccccatc acctctaaac ctttcctcat ccagaaatac acagggttac ttgtacacag     2400

ctgagggtgc acaagaagag ccacaagtag aacctcttga tctttcacta ccaaagcaac     2460

agggagaatt attagaaagg tcaactatca ctagtgttta ccagaacagt gtttattctg     2520

tccaggaaga acccttgaac ttgtcttgcg caaaaaagga gccacaaaag gacagttgtg     2580

ttacagactc agaaccagtt gtaaatgtaa tcccaccaag tgccaacccc ataaatatcg     2640

ctatacctac agtcactgcc cagttaccca caatcgtggc cattgctgac cagaacagtg     2700

ttccatgctt aagagcgcta gctgccaata agcaaacgat tctgattccc caggtggcat     2760

acacctactc aactacggtc agccctgcag tccaagaacc acccttgaaa gtgatccagc     2820

caaatggaaa tcaggatgaa agacaagata ctagctcaga aggagtatca aatgtagagg     2880

atcagaatga ctctgattct acaccgccca aaaagaaaat gcggaagaca gaaaatggaa     2940

tgtatgcttg tgatttgtgt gacaagatat tccaaaagag tagttcatta ttgagacata     3000

aatatgaaca cacaggtaaa agacctcatg agtgtggaat ctgtaaaaag gcatttaaac     3060

acaaacatca tttgattgaa cacatgcgat tacattctgg agaaaagccc tatcaatgtg     3120

acaaatgtgg aaagcgcttc tcacactctg ggtcttattc tcaacacatg aatcatcgct     3180

actcctactg taagagagaa gcggaagaac gtgacagcac agagcaggaa gaggcagggc     3240

ctgaaatcct ctcgaatgag cacgtgggtg ccagggcgtc tccctcacag ggcgactcgg     3300

acgagagaga gagtttgaca agggaagagg atgaagacag tgaaaaagag gaagaggagg     3360

aggataaaga gatggaagaa ttgcaggaag aaaaagaatg tgaaaaacca caaggggatg     3420

aggaagagga ggaggaggag gaagaagtgg aagaagaaga ggtagaagag gcagagaatg     3480

agggagaaga agcaaaaact gaaggtctga tgaaggatga cagggctgaa agtcaagcaa     3540

gcagcttagg acaaaaagta ggcgagagta gtgagcaagt gtctgaagaa aagacaaatg     3600

aagcctaatc gtttttctag aaggaaaata aattctaatt gataatgaat ttcgttcaat     3660

attatccttg cttttcatgg aaacacagta acctgtatgc tgtgattcct gttcactact     3720

gtgtaaagta aaaactaaaa aaatacaaaa tacaaaacac acacacacac acacacacac     3780

acacacacac acacacaaaa taaatccggg tgtgcctgaa cctcagacct agtaattttt     3840

catgcagttt tcaaagttag gaacaagttt gtaacatgca gcagattaga aaaccttaat     3900

gactcagaga gcaacaatac aagaggttaa aggaagctga ttaattagat atgcatctgg     3960

cattgtttta tcttatcagt attatcactc ttatgttggt ttattcttaa gctgtacaat     4020

tgggagaaat tttataattt tttattggta aacatatgct aaatccgctt cagtatttta     4080

ttatgttttt taaaatgtga gaacttctgc actacaaaat tcccttcaca gagaagtata     4140

atgtagttcc aacccgtgct aactaccttt tataaattca gtctagaagg tagtaatttc     4200

taatatttag atgtcttagt agagcgtatt atcatttaaa gtgtattgtt agccttaaga     4260

aagcagctga tagaagaact gaagtttctt actcacgtgg tttaaaatgg agttcaaaag     4320

attgccattg agttctgatt gcagggacta acaatgttaa tctgataagg acagcaaaat     4380

catcagaatc agtgtttgtg attgtgtttg aatatgtggt aacatatgaa ggatatgaca     4440

tgaagctttg tatctccttt ggccttaagc aagacctgtg tgctgtaagt gccatttctc     4500

agtattttca aggctctaac ccgccttcat ccaatgtgtg gcctacaata actagcattt     4560

gttgatttgt ctcttgtatc aaaattccca aataaaactt aaaaccactg actctgtcag     4620

agaaactgaa acactgggac atttcatcct tcaattcctc ggtattgatt ttatgttgat     4680

tgattttcag aatttctcta cagaaacgaa agggaaattt tctaatctgc tttatccatg     4740

tacttgcatt tcagacatgg acatgctatt gttatttggc tcataactgt ttccaaatgt     4800

tagttattat ggacccaatt tattaacaac attagctgat ttttacctat cagtattatt     4860

ttatttcttt tagtttatag atctgtgcaa catttttgta ctgtatgtct tcaaacctgg     4920

cagtattaat acccttctta ctgacatatg tacttttagt tttagaaaac ttttatattt     4980

atgtgtctta tttttatatt tctttattta ttacacagtg tagtgtataa tactgtagtt     5040

tgtattaata caataatata ttttagtatg aaaatttgga aagttgataa gatttaaagt     5100

agagatgcaa ttggttctcc tgcattgaga tttgatttaa cagtgttatg ttaacattta     5160

tacttgcctt ggactgtaga acagaactta aatgggaatg tattagtttt acaactacaa     5220

tcaagtcatt ttacctttac ccagttttta atataaaact taaattttga aattcactgt     5280

gtgactaata gcatgatgct ctgcagtttt attaagaaat cagcctaacc atacaactct     5340

catttcctta gtaagccaaa ttaggattaa cttctataaa cagtgttggg aacaatgttt     5400

aacattttgt gccaatttgt tcctgtattc atgtatgtaa gttacagatc tgactcttca     5460

tttttaagtt ccttgttaca tcatggtcat tttctagttt tttaccagac tcccatctca     5520

caataaaatg catcaacaag cctgaactgc tgtcattctt ttcatcatta tcagtatttt     5580

ctttggaaaa ctgtgaaatg gggtacattg tcatcctgca tttgattcat cttgagctga     5640

atttgggtaa cactaaatgt tttagacatt ctccactaaa ttatggattt tcttgtggct     5700

aaatgtttct ggagaggtca gagttgacaa aacctcttca caggttgctc cttcttcctg     5760

aaatccttaa tcctccgcat ttcatgcttc aggtcatttc agggaagcct gggtttagat     5820

gcctttctga ctctcagctc ctgcacttct gtcatcatac ctctgatact attatttata     5880

ttccttcccc actaggaaca ggaaccacat ttgtcatagt cactctcaca ttcctcactg     5940

cctaacaggg tgcctggcat aagttgggac aacagatatt tgttgaataa aaatataatt     6000

tgcatgttta tggagctcag ctatgttctc actttttttg cttctaattc cagaatatat     6060

gttaaatgat ctaataattt gattattttc ttataagtct tattaaacac tagtcataat     6120

agacacaata aattatgcct tctttttc                                        6148


<210> 86
<211> 906
<212> PRT
<213> Homo sapiens

<400> 86
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 87
<211> 6491
<212> DNA
<213> Homo sapiens

<400> 87
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa agttttcagt ttaaattctc aactggcaat      360

tggccgaaaa ctcccatctg aagacatgat catccaaatg tcattttgtg atttggctac      420

tgtctgcttg acataggaaa gcactatcaa gaaagactaa tggagtgact atcaaaagga      480

agtcaatgga caaccttaaa cttccaccac aagaggaata taaagaggtc cctcctgcac      540

caagaaagat ctgcagatct ttttcagtgt tcttggaggt gtggggtgtg agaacttgat      600

cagtttgtgt cagccacctt gttctctaaa gttacaaatt ataatactgt ggtagaaaca      660

aattcagatt cagatgatga agacaaactg catattgtgg aagaagaaag tgttacagat      720

gcagctgact gtgaaggtgt accagaggat gacctgccaa cagaccagac agtgttacca      780

gggaggagca gtgaaagaga agggaatgct aagaactgct gggaggatga cacaggaaag      840

gaagggcaag aaatcctggg gcctgaagct caggcagatg aagcaggatg tacagtaaaa      900

gatgatgaat gcgagtcaga tgcagaaaat gagcaaaacc atgatcctaa tgttgaagag      960

tttctacaac aacaagacac tgctgtcatt tttcctgagg cacctgaaga ggaccagagg     1020

cagggcacac cagaagccag tggtcatgat gaaaatggaa caccagatgc attttcacaa     1080

ttactcacct gtccatattg tgatagaggc tataaacgct ttacctctct gaaagaacac     1140

attaaatatc gtcatgaaaa gaatgaagat aactttagtt gctccctgtg cagttacacc     1200

tttgcataca gaacccaact tgaacgtcac atgacatcac ataaatcagg aagagatcaa     1260

agacatgtga cgcagtctgg gtgtaatcgt aaattcaaat gcactgagtg tggaaaagct     1320

ttcaaataca aacatcacct aaaagagcac ttaagaattc acagtggaga gaagccatat     1380

gaatgcccaa actgcaagaa acgcttttcc cattctggct cctatagctc acacataagc     1440

agtaagaaat gtatcagctt gatacctgtg aatgggcgac caagaacagg actcaagaca     1500

tctcagtgtt cttcaccgtc tctttcagca tcaccaggca gtcccacacg accacagata     1560

cggcaaaaga tagagaataa accccttcaa gaacaacttt ctgttaacca aattaaaact     1620

gaacctgtgg attatgaatt caaacccata gtggttgctt caggaatcaa ctgttcaacc     1680

cctttacaaa atggggtttt cactggtggt ggcccattac aggcaaccag ttctcctcag     1740

ggcatggtgc aagctgttgt tctgccaaca gttggtttgg tgtctcccat aagtatcaat     1800

ttaagtgata ttcagaatgt acttaaagtg gcggtagatg gtaatgtaat aaggcaagtg     1860

ttggagaata atcaagccaa tcttgcatcc aaagaacaag aaacaatcaa tgcttcaccc     1920

atacaacaag gtggccattc tgttatttca gccatcagtc ttcctttggt tgatcaagat     1980

ggaacaacca aaattatcat caactacagt cttgagcagc ctagccaact tcaagttgtt     2040

cctcaaaatt taaaaaaaga aaatccagtc gctacaaaca gttgtaaaag tgaaaagtta     2100

ccagaagatc ttactgttaa gtctgagaag gacaaaagct ttgaaggggg ggtgaatgat     2160

agcacttgtc ttctgtgtga tgattgtcca ggagatatta atgcacttcc agaattaaag     2220

cactatgacc taaagcagcc tactcagcct cctccactcc ctgcagcaga agctgagaag     2280

cctgagtcct ctgtttcatc agctactgga gatggcaatt tgtctcctag tcagccacct     2340

ttaaagaacc tcttgtctct cctaaaagca tattatgctt tgaatgcaca accaagtgca     2400

gaagagctct caaaaattgc tgattcagta aacctaccac tggatgtagt aaaaaagtgg     2460

tttgaaaaga tgcaagctgg acagatttca gtgcagtctt ctgaaccatc ttctcctgaa     2520

ccaggcaaag taaatatccc tgccaagaac aatgatcagc ctcaatctgc aaatgcaaat     2580

gaaccccagg acagcacagt aaatctacaa agtcctttga agatgactaa ctccccagtt     2640

ttaccagtgg gatcaaccac caatggttcc agaagtagta caccatcccc atcacctcta     2700

aacctttcct catccagaaa tacacagggt tacttgtaca cagctgaggg tgcacaagaa     2760

gagccacaag tagaacctct tgatctttca ctaccaaagc aacagggaga attattagaa     2820

aggtcaacta tcactagtgt ttaccagaac agtgtttatt ctgtccagga agaacccttg     2880

aacttgtctt gcgcaaaaaa ggagccacaa aaggacagtt gtgttacaga ctcagaacca     2940

gttgtaaatg taatcccacc aagtgccaac cccataaata tcgctatacc tacagtcact     3000

gcccagttac ccacaatcgt ggccattgct gaccagaaca gtgttccatg cttaagagcg     3060

ctagctgcca ataagcaaac gattctgatt ccccaggtgg catacaccta ctcaactacg     3120

gtcagccctg cagtccaaga accacccttg aaagtgatcc agccaaatgg aaatcaggat     3180

gaaagacaag atactagctc agaaggagta tcaaatgtag aggatcagaa tgactctgat     3240

tctacaccgc ccaaaaagaa aatgcggaag acagaaaatg gaatgtatgc ttgtgatttg     3300

tgtgacaaga tattccaaaa gagtagttca ttattgagac ataaatatga acacacaggt     3360

aaaagacctc atgagtgtgg aatctgtaaa aaggcattta aacacaaaca tcatttgatt     3420

gaacacatgc gattacattc tggagaaaag ccctatcaat gtgacaaatg tggaaagcgc     3480

ttctcacact ctgggtctta ttctcaacac atgaatcatc gctactccta ctgtaagaga     3540

gaagcggaag aacgtgacag cacagagcag gaagaggcag ggcctgaaat cctctcgaat     3600

gagcacgtgg gtgccagggc gtctccctca cagggcgact cggacgagag agagagtttg     3660

acaagggaag aggatgaaga cagtgaaaaa gaggaagagg aggaggataa agagatggaa     3720

gaattgcagg aagaaaaaga atgtgaaaaa ccacaagggg atgaggaaga ggaggaggag     3780

gaggaagaag tggaagaaga agaggtagaa gaggcagaga atgagggaga agaagcaaaa     3840

actgaaggtc tgatgaagga tgacagggct gaaagtcaag caagcagctt aggacaaaaa     3900

gtaggcgaga gtagtgagca agtgtctgaa gaaaagacaa atgaagccta atcgtttttc     3960

tagaaggaaa ataaattcta attgataatg aatttcgttc aatattatcc ttgcttttca     4020

tggaaacaca gtaacctgta tgctgtgatt cctgttcact actgtgtaaa gtaaaaacta     4080

aaaaaataca aaatacaaaa cacacacaca cacacacaca cacacacaca cacacacaca     4140

aaataaatcc gggtgtgcct gaacctcaga cctagtaatt tttcatgcag ttttcaaagt     4200

taggaacaag tttgtaacat gcagcagatt agaaaacctt aatgactcag agagcaacaa     4260

tacaagaggt taaaggaagc tgattaatta gatatgcatc tggcattgtt ttatcttatc     4320

agtattatca ctcttatgtt ggtttattct taagctgtac aattgggaga aattttataa     4380

ttttttattg gtaaacatat gctaaatccg cttcagtatt ttattatgtt ttttaaaatg     4440

tgagaacttc tgcactacaa aattcccttc acagagaagt ataatgtagt tccaacccgt     4500

gctaactacc ttttataaat tcagtctaga aggtagtaat ttctaatatt tagatgtctt     4560

agtagagcgt attatcattt aaagtgtatt gttagcctta agaaagcagc tgatagaaga     4620

actgaagttt cttactcacg tggtttaaaa tggagttcaa aagattgcca ttgagttctg     4680

attgcaggga ctaacaatgt taatctgata aggacagcaa aatcatcaga atcagtgttt     4740

gtgattgtgt ttgaatatgt ggtaacatat gaaggatatg acatgaagct ttgtatctcc     4800

tttggcctta agcaagacct gtgtgctgta agtgccattt ctcagtattt tcaaggctct     4860

aacccgcctt catccaatgt gtggcctaca ataactagca tttgttgatt tgtctcttgt     4920

atcaaaattc ccaaataaaa cttaaaacca ctgactctgt cagagaaact gaaacactgg     4980

gacatttcat ccttcaattc ctcggtattg attttatgtt gattgatttt cagaatttct     5040

ctacagaaac gaaagggaaa ttttctaatc tgctttatcc atgtacttgc atttcagaca     5100

tggacatgct attgttattt ggctcataac tgtttccaaa tgttagttat tatggaccca     5160

atttattaac aacattagct gatttttacc tatcagtatt attttatttc ttttagttta     5220

tagatctgtg caacattttt gtactgtatg tcttcaaacc tggcagtatt aatacccttc     5280

ttactgacat atgtactttt agttttagaa aacttttata tttatgtgtc ttatttttat     5340

atttctttat ttattacaca gtgtagtgta taatactgta gtttgtatta atacaataat     5400

atattttagt atgaaaattt ggaaagttga taagatttaa agtagagatg caattggttc     5460

tcctgcattg agatttgatt taacagtgtt atgttaacat ttatacttgc cttggactgt     5520

agaacagaac ttaaatggga atgtattagt tttacaacta caatcaagtc attttacctt     5580

tacccagttt ttaatataaa acttaaattt tgaaattcac tgtgtgacta atagcatgat     5640

gctctgcagt tttattaaga aatcagccta accatacaac tctcatttcc ttagtaagcc     5700

aaattaggat taacttctat aaacagtgtt gggaacaatg tttaacattt tgtgccaatt     5760

tgttcctgta ttcatgtatg taagttacag atctgactct tcatttttaa gttccttgtt     5820

acatcatggt cattttctag ttttttacca gactcccatc tcacaataaa atgcatcaac     5880

aagcctgaac tgctgtcatt cttttcatca ttatcagtat tttctttgga aaactgtgaa     5940

atggggtaca ttgtcatcct gcatttgatt catcttgagc tgaatttggg taacactaaa     6000

tgttttagac attctccact aaattatgga ttttcttgtg gctaaatgtt tctggagagg     6060

tcagagttga caaaacctct tcacaggttg ctccttcttc ctgaaatcct taatcctccg     6120

catttcatgc ttcaggtcat ttcagggaag cctgggttta gatgcctttc tgactctcag     6180

ctcctgcact tctgtcatca tacctctgat actattattt atattccttc cccactagga     6240

acaggaacca catttgtcat agtcactctc acattcctca ctgcctaaca gggtgcctgg     6300

cataagttgg gacaacagat atttgttgaa taaaaatata atttgcatgt ttatggagct     6360

cagctatgtt ctcacttttt ttgcttctaa ttccagaata tatgttaaat gatctaataa     6420

tttgattatt ttcttataag tcttattaaa cactagtcat aatagacaca ataaattatg     6480

ccttcttttt c                                                          6491


<210> 88
<211> 906
<212> PRT
<213> Homo sapiens

<400> 88
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 89
<211> 6430
<212> DNA
<213> Homo sapiens

<400> 89
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa agctgtttaa ggaagacaga gcaggcattg      360

gataatattc ttattaagga aagcactatc aagaaagact aatggagtga ctatcaaaag      420

gaagtcaatg gacaacctta aacttccacc acaagaggaa tataaagagg tccctcctgc      480

accaagaaag atctgcagat ctttttcagt gttcttggag gtgtggggtg tgagaacttg      540

atcagtttgt gtcagccacc ttgttctcta aagttacaaa ttataatact gtggtagaaa      600

caaattcaga ttcagatgat gaagacaaac tgcatattgt ggaagaagaa agtgttacag      660

atgcagctga ctgtgaaggt gtaccagagg atgacctgcc aacagaccag acagtgttac      720

cagggaggag cagtgaaaga gaagggaatg ctaagaactg ctgggaggat gacagaaagg      780

aagggcaaga aatcctgggg cctgaagctc aggcagatga agcaggatgt acagtaaaag      840

atgatgaatg cgagtcagat gcagaaaatg agcaaaacca tgatcctaat gttgaagagt      900

ttctacaaca acaagacact gctgtcattt ttcctgaggc acctgaagag gaccagaggc      960

agggcacacc agaagccagt ggtcatgatg aaaatggaac accagatgca ttttcacaat     1020

tactcacctg tccatattgt gatagaggct ataaacgctt tacctctctg aaagaacaca     1080

ttaaatatcg tcatgaaaag aatgaagata actttagttg ctccctgtgc agttacacct     1140

ttgcatacag aacccaactt gaacgtcaca tgacatcaca taaatcagga agagatcaaa     1200

gacatgtgac gcagtctggg tgtaatcgta aattcaaatg cactgagtgt ggaaaagctt     1260

tcaaatacaa acatcaccta aaagagcact taagaattca cagtggagag aagccatatg     1320

aatgcccaaa ctgcaagaaa cgcttttccc attctggctc ctatagctca cacataagca     1380

gtaagaaatg tatcagcttg atacctgtga atgggcgacc aagaacagga ctcaagacat     1440

ctcagtgttc ttcaccgtct ctttcagcat caccaggcag tcccacacga ccacagatac     1500

ggcaaaagat agagaataaa ccccttcaag aacaactttc tgttaaccaa attaaaactg     1560

aacctgtgga ttatgaattc aaacccatag tggttgcttc aggaatcaac tgttcaaccc     1620

ctttacaaaa tggggttttc actggtggtg gcccattaca ggcaaccagt tctcctcagg     1680

gcatggtgca agctgttgtt ctgccaacag ttggtttggt gtctcccata agtatcaatt     1740

taagtgatat tcagaatgta cttaaagtgg cggtagatgg taatgtaata aggcaagtgt     1800

tggagaataa tcaagccaat cttgcatcca aagaacaaga aacaatcaat gcttcaccca     1860

tacaacaagg tggccattct gttatttcag ccatcagtct tcctttggtt gatcaagatg     1920

gaacaaccaa aattatcatc aactacagtc ttgagcagcc tagccaactt caagttgttc     1980

ctcaaaattt aaaaaaagaa aatccagtcg ctacaaacag ttgtaaaagt gaaaagttac     2040

cagaagatct tactgttaag tctgagaagg acaaaagctt tgaagggggg gtgaatgata     2100

gcacttgtct tctgtgtgat gattgtccag gagatattaa tgcacttcca gaattaaagc     2160

actatgacct aaagcagcct actcagcctc ctccactccc tgcagcagaa gctgagaagc     2220

ctgagtcctc tgtttcatca gctactggag atggcaattt gtctcctagt cagccacctt     2280

taaagaacct cttgtctctc ctaaaagcat attatgcttt gaatgcacaa ccaagtgcag     2340

aagagctctc aaaaattgct gattcagtaa acctaccact ggatgtagta aaaaagtggt     2400

ttgaaaagat gcaagctgga cagatttcag tgcagtcttc tgaaccatct tctcctgaac     2460

caggcaaagt aaatatccct gccaagaaca atgatcagcc tcaatctgca aatgcaaatg     2520

aaccccagga cagcacagta aatctacaaa gtcctttgaa gatgactaac tccccagttt     2580

taccagtggg atcaaccacc aatggttcca gaagtagtac accatcccca tcacctctaa     2640

acctttcctc atccagaaat acacagggtt acttgtacac agctgagggt gcacaagaag     2700

agccacaagt agaacctctt gatctttcac taccaaagca acagggagaa ttattagaaa     2760

ggtcaactat cactagtgtt taccagaaca gtgtttattc tgtccaggaa gaacccttga     2820

acttgtcttg cgcaaaaaag gagccacaaa aggacagttg tgttacagac tcagaaccag     2880

ttgtaaatgt aatcccacca agtgccaacc ccataaatat cgctatacct acagtcactg     2940

cccagttacc cacaatcgtg gccattgctg accagaacag tgttccatgc ttaagagcgc     3000

tagctgccaa taagcaaacg attctgattc cccaggtggc atacacctac tcaactacgg     3060

tcagccctgc agtccaagaa ccacccttga aagtgatcca gccaaatgga aatcaggatg     3120

aaagacaaga tactagctca gaaggagtat caaatgtaga ggatcagaat gactctgatt     3180

ctacaccgcc caaaaagaaa atgcggaaga cagaaaatgg aatgtatgct tgtgatttgt     3240

gtgacaagat attccaaaag agtagttcat tattgagaca taaatatgaa cacacaggta     3300

aaagacctca tgagtgtgga atctgtaaaa aggcatttaa acacaaacat catttgattg     3360

aacacatgcg attacattct ggagaaaagc cctatcaatg tgacaaatgt ggaaagcgct     3420

tctcacactc tgggtcttat tctcaacaca tgaatcatcg ctactcctac tgtaagagag     3480

aagcggaaga acgtgacagc acagagcagg aagaggcagg gcctgaaatc ctctcgaatg     3540

agcacgtggg tgccagggcg tctccctcac agggcgactc ggacgagaga gagagtttga     3600

caagggaaga ggatgaagac agtgaaaaag aggaagagga ggaggataaa gagatggaag     3660

aattgcagga agaaaaagaa tgtgaaaaac cacaagggga tgaggaagag gaggaggagg     3720

aggaagaagt ggaagaagaa gaggtagaag aggcagagaa tgagggagaa gaagcaaaaa     3780

ctgaaggtct gatgaaggat gacagggctg aaagtcaagc aagcagctta ggacaaaaag     3840

taggcgagag tagtgagcaa gtgtctgaag aaaagacaaa tgaagcctaa tcgtttttct     3900

agaaggaaaa taaattctaa ttgataatga atttcgttca atattatcct tgcttttcat     3960

ggaaacacag taacctgtat gctgtgattc ctgttcacta ctgtgtaaag taaaaactaa     4020

aaaaatacaa aatacaaaac acacacacac acacacacac acacacacac acacacacaa     4080

aataaatccg ggtgtgcctg aacctcagac ctagtaattt ttcatgcagt tttcaaagtt     4140

aggaacaagt ttgtaacatg cagcagatta gaaaacctta atgactcaga gagcaacaat     4200

acaagaggtt aaaggaagct gattaattag atatgcatct ggcattgttt tatcttatca     4260

gtattatcac tcttatgttg gtttattctt aagctgtaca attgggagaa attttataat     4320

tttttattgg taaacatatg ctaaatccgc ttcagtattt tattatgttt tttaaaatgt     4380

gagaacttct gcactacaaa attcccttca cagagaagta taatgtagtt ccaacccgtg     4440

ctaactacct tttataaatt cagtctagaa ggtagtaatt tctaatattt agatgtctta     4500

gtagagcgta ttatcattta aagtgtattg ttagccttaa gaaagcagct gatagaagaa     4560

ctgaagtttc ttactcacgt ggtttaaaat ggagttcaaa agattgccat tgagttctga     4620

ttgcagggac taacaatgtt aatctgataa ggacagcaaa atcatcagaa tcagtgtttg     4680

tgattgtgtt tgaatatgtg gtaacatatg aaggatatga catgaagctt tgtatctcct     4740

ttggccttaa gcaagacctg tgtgctgtaa gtgccatttc tcagtatttt caaggctcta     4800

acccgccttc atccaatgtg tggcctacaa taactagcat ttgttgattt gtctcttgta     4860

tcaaaattcc caaataaaac ttaaaaccac tgactctgtc agagaaactg aaacactggg     4920

acatttcatc cttcaattcc tcggtattga ttttatgttg attgattttc agaatttctc     4980

tacagaaacg aaagggaaat tttctaatct gctttatcca tgtacttgca tttcagacat     5040

ggacatgcta ttgttatttg gctcataact gtttccaaat gttagttatt atggacccaa     5100

tttattaaca acattagctg atttttacct atcagtatta ttttatttct tttagtttat     5160

agatctgtgc aacatttttg tactgtatgt cttcaaacct ggcagtatta atacccttct     5220

tactgacata tgtactttta gttttagaaa acttttatat ttatgtgtct tatttttata     5280

tttctttatt tattacacag tgtagtgtat aatactgtag tttgtattaa tacaataata     5340

tattttagta tgaaaatttg gaaagttgat aagatttaaa gtagagatgc aattggttct     5400

cctgcattga gatttgattt aacagtgtta tgttaacatt tatacttgcc ttggactgta     5460

gaacagaact taaatgggaa tgtattagtt ttacaactac aatcaagtca ttttaccttt     5520

acccagtttt taatataaaa cttaaatttt gaaattcact gtgtgactaa tagcatgatg     5580

ctctgcagtt ttattaagaa atcagcctaa ccatacaact ctcatttcct tagtaagcca     5640

aattaggatt aacttctata aacagtgttg ggaacaatgt ttaacatttt gtgccaattt     5700

gttcctgtat tcatgtatgt aagttacaga tctgactctt catttttaag ttccttgtta     5760

catcatggtc attttctagt tttttaccag actcccatct cacaataaaa tgcatcaaca     5820

agcctgaact gctgtcattc ttttcatcat tatcagtatt ttctttggaa aactgtgaaa     5880

tggggtacat tgtcatcctg catttgattc atcttgagct gaatttgggt aacactaaat     5940

gttttagaca ttctccacta aattatggat tttcttgtgg ctaaatgttt ctggagaggt     6000

cagagttgac aaaacctctt cacaggttgc tccttcttcc tgaaatcctt aatcctccgc     6060

atttcatgct tcaggtcatt tcagggaagc ctgggtttag atgcctttct gactctcagc     6120

tcctgcactt ctgtcatcat acctctgata ctattattta tattccttcc ccactaggaa     6180

caggaaccac atttgtcata gtcactctca cattcctcac tgcctaacag ggtgcctggc     6240

ataagttggg acaacagata tttgttgaat aaaaatataa tttgcatgtt tatggagctc     6300

agctatgttc tcactttttt tgcttctaat tccagaatat atgttaaatg atctaataat     6360

ttgattattt tcttataagt cttattaaac actagtcata atagacacaa taaattatgc     6420

cttctttttc                                                            6430


<210> 90
<211> 906
<212> PRT
<213> Homo sapiens

<400> 90
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 91
<211> 6414
<212> DNA
<213> Homo sapiens

<400> 91
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa aggacaacct taaacttcca ccacaagagg      360

aatataaaga ggtccctcct gcaccaagaa agatctgcag atctttttca gtgttcttgg      420

aggtgtgggg tgtgagaact tgatcagttt gtgtcagcca ccttgttctc taaagggaaa      480

gcccctcaaa ccattttgta ttctgtatta cacttcagaa agtgtggaag caaaggtcat      540

ctaatcttta aaagttacaa attataatac tgtggtagaa acaaattcag attcagatga      600

tgaagacaaa ctgcatattg tggaagaaga aagtgttaca gatgcagctg actgtgaagg      660

tgtaccagag gatgacctgc caacagacca gacagtgtta ccagggagga gcagtgaaag      720

agaagggaat gctaagaact gctgggagga tgacacagga aaggaagggc aagaaatcct      780

ggggcctgaa gctcaggcag atgaagcagg atgtacagta aaagatgatg aatgcgagtc      840

agatgcagaa aatgagcaaa accatgatcc taatgttgaa gagtttctac aacaacaaga      900

cactgctgtc atttttcctg aggcacctga agaggaccag aggcagggca caccagaagc      960

cagtggtcat gatgaaaatg gaacaccaga tgcattttca caattactca cctgtccata     1020

ttgtgataga ggctataaac gctttacctc tctgaaagaa cacattaaat atcgtcatga     1080

aaagaatgaa gataacttta gttgctccct gtgcagttac acctttgcat acagaaccca     1140

acttgaacgt cacatgacat cacataaatc aggaagagat caaagacatg tgacgcagtc     1200

tgggtgtaat cgtaaattca aatgcactga gtgtggaaaa gctttcaaat acaaacatca     1260

cctaaaagag cacttaagaa ttcacagtgg agagaagcca tatgaatgcc caaactgcaa     1320

gaaacgcttt tcccattctg gctcctatag ctcacacata agcagtaaga aatgtatcag     1380

cttgatacct gtgaatgggc gaccaagaac aggactcaag acatctcagt gttcttcacc     1440

gtctctttca gcatcaccag gcagtcccac acgaccacag atacggcaaa agatagagaa     1500

taaacccctt caagaacaac tttctgttaa ccaaattaaa actgaacctg tggattatga     1560

attcaaaccc atagtggttg cttcaggaat caactgttca acccctttac aaaatggggt     1620

tttcactggt ggtggcccat tacaggcaac cagttctcct cagggcatgg tgcaagctgt     1680

tgttctgcca acagttggtt tggtgtctcc cataagtatc aatttaagtg atattcagaa     1740

tgtacttaaa gtggcggtag atggtaatgt aataaggcaa gtgttggaga ataatcaagc     1800

caatcttgca tccaaagaac aagaaacaat caatgcttca cccatacaac aaggtggcca     1860

ttctgttatt tcagccatca gtcttccttt ggttgatcaa gatggaacaa ccaaaattat     1920

catcaactac agtcttgagc agcctagcca acttcaagtt gttcctcaaa atttaaaaaa     1980

agaaaatcca gtcgctacaa acagttgtaa aagtgaaaag ttaccagaag atcttactgt     2040

taagtctgag aaggacaaaa gctttgaagg gggggtgaat gatagcactt gtcttctgtg     2100

tgatgattgt ccaggagata ttaatgcact tccagaatta aagcactatg acctaaagca     2160

gcctactcag cctcctccac tccctgcagc agaagctgag aagcctgagt cctctgtttc     2220

atcagctact ggagatggca atttgtctcc tagtcagcca cctttaaaga acctcttgtc     2280

tctcctaaaa gcatattatg ctttgaatgc acaaccaagt gcagaagagc tctcaaaaat     2340

tgctgattca gtaaacctac cactggatgt agtaaaaaag tggtttgaaa agatgcaagc     2400

tggacagatt tcagtgcagt cttctgaacc atcttctcct gaaccaggca aagtaaatat     2460

ccctgccaag aacaatgatc agcctcaatc tgcaaatgca aatgaacccc aggacagcac     2520

agtaaatcta caaagtcctt tgaagatgac taactcccca gttttaccag tgggatcaac     2580

caccaatggt tccagaagta gtacaccatc cccatcacct ctaaaccttt cctcatccag     2640

aaatacacag ggttacttgt acacagctga gggtgcacaa gaagagccac aagtagaacc     2700

tcttgatctt tcactaccaa agcaacaggg agaattatta gaaaggtcaa ctatcactag     2760

tgtttaccag aacagtgttt attctgtcca ggaagaaccc ttgaacttgt cttgcgcaaa     2820

aaaggagcca caaaaggaca gttgtgttac agactcagaa ccagttgtaa atgtaatccc     2880

accaagtgcc aaccccataa atatcgctat acctacagtc actgcccagt tacccacaat     2940

cgtggccatt gctgaccaga acagtgttcc atgcttaaga gcgctagctg ccaataagca     3000

aacgattctg attccccagg tggcatacac ctactcaact acggtcagcc ctgcagtcca     3060

agaaccaccc ttgaaagtga tccagccaaa tggaaatcag gatgaaagac aagatactag     3120

ctcagaagga gtatcaaatg tagaggatca gaatgactct gattctacac cgcccaaaaa     3180

gaaaatgcgg aagacagaaa atggaatgta tgcttgtgat ttgtgtgaca agatattcca     3240

aaagagtagt tcattattga gacataaata tgaacacaca ggtaaaagac ctcatgagtg     3300

tggaatctgt aaaaaggcat ttaaacacaa acatcatttg attgaacaca tgcgattaca     3360

ttctggagaa aagccctatc aatgtgacaa atgtggaaag cgcttctcac actctgggtc     3420

ttattctcaa cacatgaatc atcgctactc ctactgtaag agagaagcgg aagaacgtga     3480

cagcacagag caggaagagg cagggcctga aatcctctcg aatgagcacg tgggtgccag     3540

ggcgtctccc tcacagggcg actcggacga gagagagagt ttgacaaggg aagaggatga     3600

agacagtgaa aaagaggaag aggaggagga taaagagatg gaagaattgc aggaagaaaa     3660

agaatgtgaa aaaccacaag gggatgagga agaggaggag gaggaggaag aagtggaaga     3720

agaagaggta gaagaggcag agaatgaggg agaagaagca aaaactgaag gtctgatgaa     3780

ggatgacagg gctgaaagtc aagcaagcag cttaggacaa aaagtaggcg agagtagtga     3840

gcaagtgtct gaagaaaaga caaatgaagc ctaatcgttt ttctagaagg aaaataaatt     3900

ctaattgata atgaatttcg ttcaatatta tccttgcttt tcatggaaac acagtaacct     3960

gtatgctgtg attcctgttc actactgtgt aaagtaaaaa ctaaaaaaat acaaaataca     4020

aaacacacac acacacacac acacacacac acacacacac acaaaataaa tccgggtgtg     4080

cctgaacctc agacctagta atttttcatg cagttttcaa agttaggaac aagtttgtaa     4140

catgcagcag attagaaaac cttaatgact cagagagcaa caatacaaga ggttaaagga     4200

agctgattaa ttagatatgc atctggcatt gttttatctt atcagtatta tcactcttat     4260

gttggtttat tcttaagctg tacaattggg agaaatttta taatttttta ttggtaaaca     4320

tatgctaaat ccgcttcagt attttattat gttttttaaa atgtgagaac ttctgcacta     4380

caaaattccc ttcacagaga agtataatgt agttccaacc cgtgctaact accttttata     4440

aattcagtct agaaggtagt aatttctaat atttagatgt cttagtagag cgtattatca     4500

tttaaagtgt attgttagcc ttaagaaagc agctgataga agaactgaag tttcttactc     4560

acgtggttta aaatggagtt caaaagattg ccattgagtt ctgattgcag ggactaacaa     4620

tgttaatctg ataaggacag caaaatcatc agaatcagtg tttgtgattg tgtttgaata     4680

tgtggtaaca tatgaaggat atgacatgaa gctttgtatc tcctttggcc ttaagcaaga     4740

cctgtgtgct gtaagtgcca tttctcagta ttttcaaggc tctaacccgc cttcatccaa     4800

tgtgtggcct acaataacta gcatttgttg atttgtctct tgtatcaaaa ttcccaaata     4860

aaacttaaaa ccactgactc tgtcagagaa actgaaacac tgggacattt catccttcaa     4920

ttcctcggta ttgattttat gttgattgat tttcagaatt tctctacaga aacgaaaggg     4980

aaattttcta atctgcttta tccatgtact tgcatttcag acatggacat gctattgtta     5040

tttggctcat aactgtttcc aaatgttagt tattatggac ccaatttatt aacaacatta     5100

gctgattttt acctatcagt attattttat ttcttttagt ttatagatct gtgcaacatt     5160

tttgtactgt atgtcttcaa acctggcagt attaataccc ttcttactga catatgtact     5220

tttagtttta gaaaactttt atatttatgt gtcttatttt tatatttctt tatttattac     5280

acagtgtagt gtataatact gtagtttgta ttaatacaat aatatatttt agtatgaaaa     5340

tttggaaagt tgataagatt taaagtagag atgcaattgg ttctcctgca ttgagatttg     5400

atttaacagt gttatgttaa catttatact tgccttggac tgtagaacag aacttaaatg     5460

ggaatgtatt agttttacaa ctacaatcaa gtcattttac ctttacccag tttttaatat     5520

aaaacttaaa ttttgaaatt cactgtgtga ctaatagcat gatgctctgc agttttatta     5580

agaaatcagc ctaaccatac aactctcatt tccttagtaa gccaaattag gattaacttc     5640

tataaacagt gttgggaaca atgtttaaca ttttgtgcca atttgttcct gtattcatgt     5700

atgtaagtta cagatctgac tcttcatttt taagttcctt gttacatcat ggtcattttc     5760

tagtttttta ccagactccc atctcacaat aaaatgcatc aacaagcctg aactgctgtc     5820

attcttttca tcattatcag tattttcttt ggaaaactgt gaaatggggt acattgtcat     5880

cctgcatttg attcatcttg agctgaattt gggtaacact aaatgtttta gacattctcc     5940

actaaattat ggattttctt gtggctaaat gtttctggag aggtcagagt tgacaaaacc     6000

tcttcacagg ttgctccttc ttcctgaaat ccttaatcct ccgcatttca tgcttcaggt     6060

catttcaggg aagcctgggt ttagatgcct ttctgactct cagctcctgc acttctgtca     6120

tcatacctct gatactatta tttatattcc ttccccacta ggaacaggaa ccacatttgt     6180

catagtcact ctcacattcc tcactgccta acagggtgcc tggcataagt tgggacaaca     6240

gatatttgtt gaataaaaat ataatttgca tgtttatgga gctcagctat gttctcactt     6300

tttttgcttc taattccaga atatatgtta aatgatctaa taatttgatt attttcttat     6360

aagtcttatt aaacactagt cataatagac acaataaatt atgccttctt tttc           6414


<210> 92
<211> 906
<212> PRT
<213> Homo sapiens

<400> 92
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 93
<211> 6332
<212> DNA
<213> Homo sapiens

<400> 93
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa aggacaacct taaacttcca ccacaagagg      360

aatataaaga ggtccctcct gcaccaagaa agatctgcag atctttttca gtgttcttgg      420

aggtgtgggg tgtgagaact tgatcagttt gtgtcagcca ccttgttctc taaagttaca      480

aattataata ctgtggtaga aacaaattca gattcagatg atgaagacaa actgcatatt      540

gtggaagaag aaagtgttac agatgcagct gactgtgaag gtgtaccaga ggatgacctg      600

ccaacagacc agacagtgtt accagggagg agcagtgaaa gagaagggaa tgctaagaac      660

tgctgggagg atgacagaaa ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat      720

gaagcaggat gtacagtaaa agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac      780

catgatccta atgttgaaga gtttctacaa caacaagaca ctgctgtcat ttttcctgag      840

gcacctgaag aggaccagag gcagggcaca ccagaagcca gtggtcatga tgaaaatgga      900

acaccagatg cattttcaca attactcacc tgtccatatt gtgatagagg ctataaacgc      960

tttacctctc tgaaagaaca cattaaatat cgtcatgaaa agaatgaaga taactttagt     1020

tgctccctgt gcagttacac ctttgcatac agaacccaac ttgaacgtca catgacatca     1080

cataaatcag gaagagatca aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa     1140

tgcactgagt gtggaaaagc tttcaaatac aaacatcacc taaaagagca cttaagaatt     1200

cacagtggag agaagccata tgaatgccca aactgcaaga aacgcttttc ccattctggc     1260

tcctatagct cacacataag cagtaagaaa tgtatcagct tgatacctgt gaatgggcga     1320

ccaagaacag gactcaagac atctcagtgt tcttcaccgt ctctttcagc atcaccaggc     1380

agtcccacac gaccacagat acggcaaaag atagagaata aaccccttca agaacaactt     1440

tctgttaacc aaattaaaac tgaacctgtg gattatgaat tcaaacccat agtggttgct     1500

tcaggaatca actgttcaac ccctttacaa aatggggttt tcactggtgg tggcccatta     1560

caggcaacca gttctcctca gggcatggtg caagctgttg ttctgccaac agttggtttg     1620

gtgtctccca taagtatcaa tttaagtgat attcagaatg tacttaaagt ggcggtagat     1680

ggtaatgtaa taaggcaagt gttggagaat aatcaagcca atcttgcatc caaagaacaa     1740

gaaacaatca atgcttcacc catacaacaa ggtggccatt ctgttatttc agccatcagt     1800

cttcctttgg ttgatcaaga tggaacaacc aaaattatca tcaactacag tcttgagcag     1860

cctagccaac ttcaagttgt tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac     1920

agttgtaaaa gtgaaaagtt accagaagat cttactgtta agtctgagaa ggacaaaagc     1980

tttgaagggg gggtgaatga tagcacttgt cttctgtgtg atgattgtcc aggagatatt     2040

aatgcacttc cagaattaaa gcactatgac ctaaagcagc ctactcagcc tcctccactc     2100

cctgcagcag aagctgagaa gcctgagtcc tctgtttcat cagctactgg agatggcaat     2160

ttgtctccta gtcagccacc tttaaagaac ctcttgtctc tcctaaaagc atattatgct     2220

ttgaatgcac aaccaagtgc agaagagctc tcaaaaattg ctgattcagt aaacctacca     2280

ctggatgtag taaaaaagtg gtttgaaaag atgcaagctg gacagatttc agtgcagtct     2340

tctgaaccat cttctcctga accaggcaaa gtaaatatcc ctgccaagaa caatgatcag     2400

cctcaatctg caaatgcaaa tgaaccccag gacagcacag taaatctaca aagtcctttg     2460

aagatgacta actccccagt tttaccagtg ggatcaacca ccaatggttc cagaagtagt     2520

acaccatccc catcacctct aaacctttcc tcatccagaa atacacaggg ttacttgtac     2580

acagctgagg gtgcacaaga agagccacaa gtagaacctc ttgatctttc actaccaaag     2640

caacagggag aattattaga aaggtcaact atcactagtg tttaccagaa cagtgtttat     2700

tctgtccagg aagaaccctt gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt     2760

tgtgttacag actcagaacc agttgtaaat gtaatcccac caagtgccaa ccccataaat     2820

atcgctatac ctacagtcac tgcccagtta cccacaatcg tggccattgc tgaccagaac     2880

agtgttccat gcttaagagc gctagctgcc aataagcaaa cgattctgat tccccaggtg     2940

gcatacacct actcaactac ggtcagccct gcagtccaag aaccaccctt gaaagtgatc     3000

cagccaaatg gaaatcagga tgaaagacaa gatactagct cagaaggagt atcaaatgta     3060

gaggatcaga atgactctga ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat     3120

ggaatgtatg cttgtgattt gtgtgacaag atattccaaa agagtagttc attattgaga     3180

cataaatatg aacacacagg taaaagacct catgagtgtg gaatctgtaa aaaggcattt     3240

aaacacaaac atcatttgat tgaacacatg cgattacatt ctggagaaaa gccctatcaa     3300

tgtgacaaat gtggaaagcg cttctcacac tctgggtctt attctcaaca catgaatcat     3360

cgctactcct actgtaagag agaagcggaa gaacgtgaca gcacagagca ggaagaggca     3420

gggcctgaaa tcctctcgaa tgagcacgtg ggtgccaggg cgtctccctc acagggcgac     3480

tcggacgaga gagagagttt gacaagggaa gaggatgaag acagtgaaaa agaggaagag     3540

gaggaggata aagagatgga agaattgcag gaagaaaaag aatgtgaaaa accacaaggg     3600

gatgaggaag aggaggagga ggaggaagaa gtggaagaag aagaggtaga agaggcagag     3660

aatgagggag aagaagcaaa aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa     3720

gcaagcagct taggacaaaa agtaggcgag agtagtgagc aagtgtctga agaaaagaca     3780

aatgaagcct aatcgttttt ctagaaggaa aataaattct aattgataat gaatttcgtt     3840

caatattatc cttgcttttc atggaaacac agtaacctgt atgctgtgat tcctgttcac     3900

tactgtgtaa agtaaaaact aaaaaaatac aaaatacaaa acacacacac acacacacac     3960

acacacacac acacacacac aaaataaatc cgggtgtgcc tgaacctcag acctagtaat     4020

ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct     4080

taatgactca gagagcaaca atacaagagg ttaaaggaag ctgattaatt agatatgcat     4140

ctggcattgt tttatcttat cagtattatc actcttatgt tggtttattc ttaagctgta     4200

caattgggag aaattttata attttttatt ggtaaacata tgctaaatcc gcttcagtat     4260

tttattatgt tttttaaaat gtgagaactt ctgcactaca aaattccctt cacagagaag     4320

tataatgtag ttccaacccg tgctaactac cttttataaa ttcagtctag aaggtagtaa     4380

tttctaatat ttagatgtct tagtagagcg tattatcatt taaagtgtat tgttagcctt     4440

aagaaagcag ctgatagaag aactgaagtt tcttactcac gtggtttaaa atggagttca     4500

aaagattgcc attgagttct gattgcaggg actaacaatg ttaatctgat aaggacagca     4560

aaatcatcag aatcagtgtt tgtgattgtg tttgaatatg tggtaacata tgaaggatat     4620

gacatgaagc tttgtatctc ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt     4680

tctcagtatt ttcaaggctc taacccgcct tcatccaatg tgtggcctac aataactagc     4740

atttgttgat ttgtctcttg tatcaaaatt cccaaataaa acttaaaacc actgactctg     4800

tcagagaaac tgaaacactg ggacatttca tccttcaatt cctcggtatt gattttatgt     4860

tgattgattt tcagaatttc tctacagaaa cgaaagggaa attttctaat ctgctttatc     4920

catgtacttg catttcagac atggacatgc tattgttatt tggctcataa ctgtttccaa     4980

atgttagtta ttatggaccc aatttattaa caacattagc tgatttttac ctatcagtat     5040

tattttattt cttttagttt atagatctgt gcaacatttt tgtactgtat gtcttcaaac     5100

ctggcagtat taataccctt cttactgaca tatgtacttt tagttttaga aaacttttat     5160

atttatgtgt cttattttta tatttcttta tttattacac agtgtagtgt ataatactgt     5220

agtttgtatt aatacaataa tatattttag tatgaaaatt tggaaagttg ataagattta     5280

aagtagagat gcaattggtt ctcctgcatt gagatttgat ttaacagtgt tatgttaaca     5340

tttatacttg ccttggactg tagaacagaa cttaaatggg aatgtattag ttttacaact     5400

acaatcaagt cattttacct ttacccagtt tttaatataa aacttaaatt ttgaaattca     5460

ctgtgtgact aatagcatga tgctctgcag ttttattaag aaatcagcct aaccatacaa     5520

ctctcatttc cttagtaagc caaattagga ttaacttcta taaacagtgt tgggaacaat     5580

gtttaacatt ttgtgccaat ttgttcctgt attcatgtat gtaagttaca gatctgactc     5640

ttcattttta agttccttgt tacatcatgg tcattttcta gttttttacc agactcccat     5700

ctcacaataa aatgcatcaa caagcctgaa ctgctgtcat tcttttcatc attatcagta     5760

ttttctttgg aaaactgtga aatggggtac attgtcatcc tgcatttgat tcatcttgag     5820

ctgaatttgg gtaacactaa atgttttaga cattctccac taaattatgg attttcttgt     5880

ggctaaatgt ttctggagag gtcagagttg acaaaacctc ttcacaggtt gctccttctt     5940

cctgaaatcc ttaatcctcc gcatttcatg cttcaggtca tttcagggaa gcctgggttt     6000

agatgccttt ctgactctca gctcctgcac ttctgtcatc atacctctga tactattatt     6060

tatattcctt ccccactagg aacaggaacc acatttgtca tagtcactct cacattcctc     6120

actgcctaac agggtgcctg gcataagttg ggacaacaga tatttgttga ataaaaatat     6180

aatttgcatg tttatggagc tcagctatgt tctcactttt tttgcttcta attccagaat     6240

atatgttaaa tgatctaata atttgattat tttcttataa gtcttattaa acactagtca     6300

taatagacac aataaattat gccttctttt tc                                   6332


<210> 94
<211> 906
<212> PRT
<213> Homo sapiens

<400> 94
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 95
<211> 6272
<212> DNA
<213> Homo sapiens

<400> 95
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa aggacaacct taaacttcca ccacaagagg      360

aatataaaga ggtccctcct gcaccaagaa agatctgcag atctttttca gtgttcttgg      420

aggtgtgggg tgtgagaact tgatcagttt gtgtcagcca ccttgttctc taaagttaca      480

aattataata ctgtggtaga aacaaattca gattcagatg atgaagacaa actgcatatt      540

gtggaagaag aaagtgttac agatgcagct gactgtgaag gtgtaccaga ggatgacctg      600

ccaacagacc agacagtgtt accagggagg agcagtgaaa gagaagggaa tgctaagaac      660

tgctgggagg atgacataaa agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac      720

catgatccta atgttgaaga gtttctacaa caacaagaca ctgctgtcat ttttcctgag      780

gcacctgaag aggaccagag gcagggcaca ccagaagcca gtggtcatga tgaaaatgga      840

acaccagatg cattttcaca attactcacc tgtccatatt gtgatagagg ctataaacgc      900

tttacctctc tgaaagaaca cattaaatat cgtcatgaaa agaatgaaga taactttagt      960

tgctccctgt gcagttacac ctttgcatac agaacccaac ttgaacgtca catgacatca     1020

cataaatcag gaagagatca aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa     1080

tgcactgagt gtggaaaagc tttcaaatac aaacatcacc taaaagagca cttaagaatt     1140

cacagtggag agaagccata tgaatgccca aactgcaaga aacgcttttc ccattctggc     1200

tcctatagct cacacataag cagtaagaaa tgtatcagct tgatacctgt gaatgggcga     1260

ccaagaacag gactcaagac atctcagtgt tcttcaccgt ctctttcagc atcaccaggc     1320

agtcccacac gaccacagat acggcaaaag atagagaata aaccccttca agaacaactt     1380

tctgttaacc aaattaaaac tgaacctgtg gattatgaat tcaaacccat agtggttgct     1440

tcaggaatca actgttcaac ccctttacaa aatggggttt tcactggtgg tggcccatta     1500

caggcaacca gttctcctca gggcatggtg caagctgttg ttctgccaac agttggtttg     1560

gtgtctccca taagtatcaa tttaagtgat attcagaatg tacttaaagt ggcggtagat     1620

ggtaatgtaa taaggcaagt gttggagaat aatcaagcca atcttgcatc caaagaacaa     1680

gaaacaatca atgcttcacc catacaacaa ggtggccatt ctgttatttc agccatcagt     1740

cttcctttgg ttgatcaaga tggaacaacc aaaattatca tcaactacag tcttgagcag     1800

cctagccaac ttcaagttgt tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac     1860

agttgtaaaa gtgaaaagtt accagaagat cttactgtta agtctgagaa ggacaaaagc     1920

tttgaagggg gggtgaatga tagcacttgt cttctgtgtg atgattgtcc aggagatatt     1980

aatgcacttc cagaattaaa gcactatgac ctaaagcagc ctactcagcc tcctccactc     2040

cctgcagcag aagctgagaa gcctgagtcc tctgtttcat cagctactgg agatggcaat     2100

ttgtctccta gtcagccacc tttaaagaac ctcttgtctc tcctaaaagc atattatgct     2160

ttgaatgcac aaccaagtgc agaagagctc tcaaaaattg ctgattcagt aaacctacca     2220

ctggatgtag taaaaaagtg gtttgaaaag atgcaagctg gacagatttc agtgcagtct     2280

tctgaaccat cttctcctga accaggcaaa gtaaatatcc ctgccaagaa caatgatcag     2340

cctcaatctg caaatgcaaa tgaaccccag gacagcacag taaatctaca aagtcctttg     2400

aagatgacta actccccagt tttaccagtg ggatcaacca ccaatggttc cagaagtagt     2460

acaccatccc catcacctct aaacctttcc tcatccagaa atacacaggg ttacttgtac     2520

acagctgagg gtgcacaaga agagccacaa gtagaacctc ttgatctttc actaccaaag     2580

caacagggag aattattaga aaggtcaact atcactagtg tttaccagaa cagtgtttat     2640

tctgtccagg aagaaccctt gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt     2700

tgtgttacag actcagaacc agttgtaaat gtaatcccac caagtgccaa ccccataaat     2760

atcgctatac ctacagtcac tgcccagtta cccacaatcg tggccattgc tgaccagaac     2820

agtgttccat gcttaagagc gctagctgcc aataagcaaa cgattctgat tccccaggtg     2880

gcatacacct actcaactac ggtcagccct gcagtccaag aaccaccctt gaaagtgatc     2940

cagccaaatg gaaatcagga tgaaagacaa gatactagct cagaaggagt atcaaatgta     3000

gaggatcaga atgactctga ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat     3060

ggaatgtatg cttgtgattt gtgtgacaag atattccaaa agagtagttc attattgaga     3120

cataaatatg aacacacagg taaaagacct catgagtgtg gaatctgtaa aaaggcattt     3180

aaacacaaac atcatttgat tgaacacatg cgattacatt ctggagaaaa gccctatcaa     3240

tgtgacaaat gtggaaagcg cttctcacac tctgggtctt attctcaaca catgaatcat     3300

cgctactcct actgtaagag agaagcggaa gaacgtgaca gcacagagca ggaagaggca     3360

gggcctgaaa tcctctcgaa tgagcacgtg ggtgccaggg cgtctccctc acagggcgac     3420

tcggacgaga gagagagttt gacaagggaa gaggatgaag acagtgaaaa agaggaagag     3480

gaggaggata aagagatgga agaattgcag gaagaaaaag aatgtgaaaa accacaaggg     3540

gatgaggaag aggaggagga ggaggaagaa gtggaagaag aagaggtaga agaggcagag     3600

aatgagggag aagaagcaaa aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa     3660

gcaagcagct taggacaaaa agtaggcgag agtagtgagc aagtgtctga agaaaagaca     3720

aatgaagcct aatcgttttt ctagaaggaa aataaattct aattgataat gaatttcgtt     3780

caatattatc cttgcttttc atggaaacac agtaacctgt atgctgtgat tcctgttcac     3840

tactgtgtaa agtaaaaact aaaaaaatac aaaatacaaa acacacacac acacacacac     3900

acacacacac acacacacac aaaataaatc cgggtgtgcc tgaacctcag acctagtaat     3960

ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct     4020

taatgactca gagagcaaca atacaagagg ttaaaggaag ctgattaatt agatatgcat     4080

ctggcattgt tttatcttat cagtattatc actcttatgt tggtttattc ttaagctgta     4140

caattgggag aaattttata attttttatt ggtaaacata tgctaaatcc gcttcagtat     4200

tttattatgt tttttaaaat gtgagaactt ctgcactaca aaattccctt cacagagaag     4260

tataatgtag ttccaacccg tgctaactac cttttataaa ttcagtctag aaggtagtaa     4320

tttctaatat ttagatgtct tagtagagcg tattatcatt taaagtgtat tgttagcctt     4380

aagaaagcag ctgatagaag aactgaagtt tcttactcac gtggtttaaa atggagttca     4440

aaagattgcc attgagttct gattgcaggg actaacaatg ttaatctgat aaggacagca     4500

aaatcatcag aatcagtgtt tgtgattgtg tttgaatatg tggtaacata tgaaggatat     4560

gacatgaagc tttgtatctc ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt     4620

tctcagtatt ttcaaggctc taacccgcct tcatccaatg tgtggcctac aataactagc     4680

atttgttgat ttgtctcttg tatcaaaatt cccaaataaa acttaaaacc actgactctg     4740

tcagagaaac tgaaacactg ggacatttca tccttcaatt cctcggtatt gattttatgt     4800

tgattgattt tcagaatttc tctacagaaa cgaaagggaa attttctaat ctgctttatc     4860

catgtacttg catttcagac atggacatgc tattgttatt tggctcataa ctgtttccaa     4920

atgttagtta ttatggaccc aatttattaa caacattagc tgatttttac ctatcagtat     4980

tattttattt cttttagttt atagatctgt gcaacatttt tgtactgtat gtcttcaaac     5040

ctggcagtat taataccctt cttactgaca tatgtacttt tagttttaga aaacttttat     5100

atttatgtgt cttattttta tatttcttta tttattacac agtgtagtgt ataatactgt     5160

agtttgtatt aatacaataa tatattttag tatgaaaatt tggaaagttg ataagattta     5220

aagtagagat gcaattggtt ctcctgcatt gagatttgat ttaacagtgt tatgttaaca     5280

tttatacttg ccttggactg tagaacagaa cttaaatggg aatgtattag ttttacaact     5340

acaatcaagt cattttacct ttacccagtt tttaatataa aacttaaatt ttgaaattca     5400

ctgtgtgact aatagcatga tgctctgcag ttttattaag aaatcagcct aaccatacaa     5460

ctctcatttc cttagtaagc caaattagga ttaacttcta taaacagtgt tgggaacaat     5520

gtttaacatt ttgtgccaat ttgttcctgt attcatgtat gtaagttaca gatctgactc     5580

ttcattttta agttccttgt tacatcatgg tcattttcta gttttttacc agactcccat     5640

ctcacaataa aatgcatcaa caagcctgaa ctgctgtcat tcttttcatc attatcagta     5700

ttttctttgg aaaactgtga aatggggtac attgtcatcc tgcatttgat tcatcttgag     5760

ctgaatttgg gtaacactaa atgttttaga cattctccac taaattatgg attttcttgt     5820

ggctaaatgt ttctggagag gtcagagttg acaaaacctc ttcacaggtt gctccttctt     5880

cctgaaatcc ttaatcctcc gcatttcatg cttcaggtca tttcagggaa gcctgggttt     5940

agatgccttt ctgactctca gctcctgcac ttctgtcatc atacctctga tactattatt     6000

tatattcctt ccccactagg aacaggaacc acatttgtca tagtcactct cacattcctc     6060

actgcctaac agggtgcctg gcataagttg ggacaacaga tatttgttga ataaaaatat     6120

aatttgcatg tttatggagc tcagctatgt tctcactttt tttgcttcta attccagaat     6180

atatgttaaa tgatctaata atttgattat tttcttataa gtcttattaa acactagtca     6240

taatagacac aataaattat gccttctttt tc                                   6272


<210> 96
<211> 906
<212> PRT
<213> Homo sapiens

<400> 96
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 97
<211> 6195
<212> DNA
<213> Homo sapiens

<400> 97
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc aggacaacct taaacttcca ccacaagagg aatataaaga ggtccctcct      240

gcaccaagaa agatctgcag atctttttca gtgttcttgg aggtgtgggg tgtgagaact      300

tgatcagttt gtgtcagcca ccttgttctc taaagttaca aattataata ctgtggtaga      360

aacaaattca gattcagatg atgaagacaa actgcatatt gtggaagaag aaagtgttac      420

agatgcagct gactgtgaag gtgtaccaga ggatgacctg ccaacagacc agacagtgtt      480

accagggagg agcagtgaaa gagaagggaa tgctaagaac tgctgggagg atgacacagg      540

aaaggaaggg caagaaatcc tggggcctga agctcaggca gatgaagcag gatgtacagt      600

aaaagatgat gaatgcgagt cagatgcaga aaatgagcaa aaccatgatc ctaatgttga      660

agagtttcta caacaacaag acactgctgt catttttcct gaggcacctg aagaggacca      720

gaggcagggc acaccagaag ccagtggtca tgatgaaaat ggaacaccag atgcattttc      780

acaattactc acctgtccat attgtgatag aggctataaa cgctttacct ctctgaaaga      840

acacattaaa tatcgtcatg aaaagaatga agataacttt agttgctccc tgtgcagtta      900

cacctttgca tacagaaccc aacttgaacg tcacatgaca tcacataaat caggaagaga      960

tcaaagacat gtgacgcagt ctgggtgtaa tcgtaaattc aaatgcactg agtgtggaaa     1020

agctttcaaa tacaaacatc acctaaaaga gcacttaaga attcacagtg gagagaagcc     1080

atatgaatgc ccaaactgca agaaacgctt ttcccattct ggctcctata gctcacacat     1140

aagcagtaag aaatgtatca gcttgatacc tgtgaatggg cgaccaagaa caggactcaa     1200

gacatctcag tgttcttcac cgtctctttc agcatcacca ggcagtccca cacgaccaca     1260

gatacggcaa aagatagaga ataaacccct tcaagaacaa ctttctgtta accaaattaa     1320

aactgaacct gtggattatg aattcaaacc catagtggtt gcttcaggaa tcaactgttc     1380

aaccccttta caaaatgggg ttttcactgg tggtggccca ttacaggcaa ccagttctcc     1440

tcagggcatg gtgcaagctg ttgttctgcc aacagttggt ttggtgtctc ccataagtat     1500

caatttaagt gatattcaga atgtacttaa agtggcggta gatggtaatg taataaggca     1560

agtgttggag aataatcaag ccaatcttgc atccaaagaa caagaaacaa tcaatgcttc     1620

acccatacaa caaggtggcc attctgttat ttcagccatc agtcttcctt tggttgatca     1680

agatggaaca accaaaatta tcatcaacta cagtcttgag cagcctagcc aacttcaagt     1740

tgttcctcaa aatttaaaaa aagaaaatcc agtcgctaca aacagttgta aaagtgaaaa     1800

gttaccagaa gatcttactg ttaagtctga gaaggacaaa agctttgaag ggggggtgaa     1860

tgatagcact tgtcttctgt gtgatgattg tccaggagat attaatgcac ttccagaatt     1920

aaagcactat gacctaaagc agcctactca gcctcctcca ctccctgcag cagaagctga     1980

gaagcctgag tcctctgttt catcagctac tggagatggc aatttgtctc ctagtcagcc     2040

acctttaaag aacctcttgt ctctcctaaa agcatattat gctttgaatg cacaaccaag     2100

tgcagaagag ctctcaaaaa ttgctgattc agtaaaccta ccactggatg tagtaaaaaa     2160

gtggtttgaa aagatgcaag ctggacagat ttcagtgcag tcttctgaac catcttctcc     2220

tgaaccaggc aaagtaaata tccctgccaa gaacaatgat cagcctcaat ctgcaaatgc     2280

aaatgaaccc caggacagca cagtaaatct acaaagtcct ttgaagatga ctaactcccc     2340

agttttacca gtgggatcaa ccaccaatgg ttccagaagt agtacaccat ccccatcacc     2400

tctaaacctt tcctcatcca gaaatacaca gggttacttg tacacagctg agggtgcaca     2460

agaagagcca caagtagaac ctcttgatct ttcactacca aagcaacagg gagaattatt     2520

agaaaggtca actatcacta gtgtttacca gaacagtgtt tattctgtcc aggaagaacc     2580

cttgaacttg tcttgcgcaa aaaaggagcc acaaaaggac agttgtgtta cagactcaga     2640

accagttgta aatgtaatcc caccaagtgc caaccccata aatatcgcta tacctacagt     2700

cactgcccag ttacccacaa tcgtggccat tgctgaccag aacagtgttc catgcttaag     2760

agcgctagct gccaataagc aaacgattct gattccccag gtggcataca cctactcaac     2820

tacggtcagc cctgcagtcc aagaaccacc cttgaaagtg atccagccaa atggaaatca     2880

ggatgaaaga caagatacta gctcagaagg agtatcaaat gtagaggatc agaatgactc     2940

tgattctaca ccgcccaaaa agaaaatgcg gaagacagaa aatggaatgt atgcttgtga     3000

tttgtgtgac aagatattcc aaaagagtag ttcattattg agacataaat atgaacacac     3060

aggtaaaaga cctcatgagt gtggaatctg taaaaaggca tttaaacaca aacatcattt     3120

gattgaacac atgcgattac attctggaga aaagccctat caatgtgaca aatgtggaaa     3180

gcgcttctca cactctgggt cttattctca acacatgaat catcgctact cctactgtaa     3240

gagagaagcg gaagaacgtg acagcacaga gcaggaagag gcagggcctg aaatcctctc     3300

gaatgagcac gtgggtgcca gggcgtctcc ctcacagggc gactcggacg agagagagag     3360

tttgacaagg gaagaggatg aagacagtga aaaagaggaa gaggaggagg ataaagagat     3420

ggaagaattg caggaagaaa aagaatgtga aaaaccacaa ggggatgagg aagaggagga     3480

ggaggaggaa gaagtggaag aagaagaggt agaagaggca gagaatgagg gagaagaagc     3540

aaaaactgaa ggtctgatga aggatgacag ggctgaaagt caagcaagca gcttaggaca     3600

aaaagtaggc gagagtagtg agcaagtgtc tgaagaaaag acaaatgaag cctaatcgtt     3660

tttctagaag gaaaataaat tctaattgat aatgaatttc gttcaatatt atccttgctt     3720

ttcatggaaa cacagtaacc tgtatgctgt gattcctgtt cactactgtg taaagtaaaa     3780

actaaaaaaa tacaaaatac aaaacacaca cacacacaca cacacacaca cacacacaca     3840

cacaaaataa atccgggtgt gcctgaacct cagacctagt aatttttcat gcagttttca     3900

aagttaggaa caagtttgta acatgcagca gattagaaaa ccttaatgac tcagagagca     3960

acaatacaag aggttaaagg aagctgatta attagatatg catctggcat tgttttatct     4020

tatcagtatt atcactctta tgttggttta ttcttaagct gtacaattgg gagaaatttt     4080

ataatttttt attggtaaac atatgctaaa tccgcttcag tattttatta tgttttttaa     4140

aatgtgagaa cttctgcact acaaaattcc cttcacagag aagtataatg tagttccaac     4200

ccgtgctaac taccttttat aaattcagtc tagaaggtag taatttctaa tatttagatg     4260

tcttagtaga gcgtattatc atttaaagtg tattgttagc cttaagaaag cagctgatag     4320

aagaactgaa gtttcttact cacgtggttt aaaatggagt tcaaaagatt gccattgagt     4380

tctgattgca gggactaaca atgttaatct gataaggaca gcaaaatcat cagaatcagt     4440

gtttgtgatt gtgtttgaat atgtggtaac atatgaagga tatgacatga agctttgtat     4500

ctcctttggc cttaagcaag acctgtgtgc tgtaagtgcc atttctcagt attttcaagg     4560

ctctaacccg ccttcatcca atgtgtggcc tacaataact agcatttgtt gatttgtctc     4620

ttgtatcaaa attcccaaat aaaacttaaa accactgact ctgtcagaga aactgaaaca     4680

ctgggacatt tcatccttca attcctcggt attgatttta tgttgattga ttttcagaat     4740

ttctctacag aaacgaaagg gaaattttct aatctgcttt atccatgtac ttgcatttca     4800

gacatggaca tgctattgtt atttggctca taactgtttc caaatgttag ttattatgga     4860

cccaatttat taacaacatt agctgatttt tacctatcag tattatttta tttcttttag     4920

tttatagatc tgtgcaacat ttttgtactg tatgtcttca aacctggcag tattaatacc     4980

cttcttactg acatatgtac ttttagtttt agaaaacttt tatatttatg tgtcttattt     5040

ttatatttct ttatttatta cacagtgtag tgtataatac tgtagtttgt attaatacaa     5100

taatatattt tagtatgaaa atttggaaag ttgataagat ttaaagtaga gatgcaattg     5160

gttctcctgc attgagattt gatttaacag tgttatgtta acatttatac ttgccttgga     5220

ctgtagaaca gaacttaaat gggaatgtat tagttttaca actacaatca agtcatttta     5280

cctttaccca gtttttaata taaaacttaa attttgaaat tcactgtgtg actaatagca     5340

tgatgctctg cagttttatt aagaaatcag cctaaccata caactctcat ttccttagta     5400

agccaaatta ggattaactt ctataaacag tgttgggaac aatgtttaac attttgtgcc     5460

aatttgttcc tgtattcatg tatgtaagtt acagatctga ctcttcattt ttaagttcct     5520

tgttacatca tggtcatttt ctagtttttt accagactcc catctcacaa taaaatgcat     5580

caacaagcct gaactgctgt cattcttttc atcattatca gtattttctt tggaaaactg     5640

tgaaatgggg tacattgtca tcctgcattt gattcatctt gagctgaatt tgggtaacac     5700

taaatgtttt agacattctc cactaaatta tggattttct tgtggctaaa tgtttctgga     5760

gaggtcagag ttgacaaaac ctcttcacag gttgctcctt cttcctgaaa tccttaatcc     5820

tccgcatttc atgcttcagg tcatttcagg gaagcctggg tttagatgcc tttctgactc     5880

tcagctcctg cacttctgtc atcatacctc tgatactatt atttatattc cttccccact     5940

aggaacagga accacatttg tcatagtcac tctcacattc ctcactgcct aacagggtgc     6000

ctggcataag ttgggacaac agatatttgt tgaataaaaa tataatttgc atgtttatgg     6060

agctcagcta tgttctcact ttttttgctt ctaattccag aatatatgtt aaatgatcta     6120

ataatttgat tattttctta taagtcttat taaacactag tcataataga cacaataaat     6180

tatgccttct ttttc                                                      6195


<210> 98
<211> 906
<212> PRT
<213> Homo sapiens

<400> 98
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 99
<211> 6247
<212> DNA
<213> Homo sapiens

<400> 99
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc aggaaagcac tatcaagaaa gactaatgga gtgactatca aaaggaagtc      240

aatggacaac cttaaacttc caccacaaga ggaatataaa gaggtccctc ctgcaccaag      300

aaagatctgc agatcttttt cagtgttctt ggaggtgtgg ggtgtgagaa cttgatcagt      360

ttgtgtcagc caccttgttc tctaaagtta caaattataa tactgtggta gaaacaaatt      420

cagattcaga tgatgaagac aaactgcata ttgtggaaga agaaagtgtt acagatgcag      480

ctgactgtga aggtgtacca gaggatgacc tgccaacaga ccagacagtg ttaccaggga      540

ggagcagtga aagagaaggg aatgctaaga actgctggga ggatgacaca ggaaaggaag      600

ggcaagaaat cctggggcct gaagctcagg cagatgaagc aggatgtaca gtaaaagatg      660

atgaatgcga gtcagatgca gaaaatgagc aaaaccatga tcctaatgtt gaagagtttc      720

tacaacaaca agacactgct gtcatttttc ctgaggcacc tgaagaggac cagaggcagg      780

gcacaccaga agccagtggt catgatgaaa atggaacacc agatgcattt tcacaattac      840

tcacctgtcc atattgtgat agaggctata aacgctttac ctctctgaaa gaacacatta      900

aatatcgtca tgaaaagaat gaagataact ttagttgctc cctgtgcagt tacacctttg      960

catacagaac ccaacttgaa cgtcacatga catcacataa atcaggaaga gatcaaagac     1020

atgtgacgca gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga aaagctttca     1080

aatacaaaca tcacctaaaa gagcacttaa gaattcacag tggagagaag ccatatgaat     1140

gcccaaactg caagaaacgc ttttcccatt ctggctccta tagctcacac ataagcagta     1200

agaaatgtat cagcttgata cctgtgaatg ggcgaccaag aacaggactc aagacatctc     1260

agtgttcttc accgtctctt tcagcatcac caggcagtcc cacacgacca cagatacggc     1320

aaaagataga gaataaaccc cttcaagaac aactttctgt taaccaaatt aaaactgaac     1380

ctgtggatta tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt tcaacccctt     1440

tacaaaatgg ggttttcact ggtggtggcc cattacaggc aaccagttct cctcagggca     1500

tggtgcaagc tgttgttctg ccaacagttg gtttggtgtc tcccataagt atcaatttaa     1560

gtgatattca gaatgtactt aaagtggcgg tagatggtaa tgtaataagg caagtgttgg     1620

agaataatca agccaatctt gcatccaaag aacaagaaac aatcaatgct tcacccatac     1680

aacaaggtgg ccattctgtt atttcagcca tcagtcttcc tttggttgat caagatggaa     1740

caaccaaaat tatcatcaac tacagtcttg agcagcctag ccaacttcaa gttgttcctc     1800

aaaatttaaa aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa aagttaccag     1860

aagatcttac tgttaagtct gagaaggaca aaagctttga agggggggtg aatgatagca     1920

cttgtcttct gtgtgatgat tgtccaggag atattaatgc acttccagaa ttaaagcact     1980

atgacctaaa gcagcctact cagcctcctc cactccctgc agcagaagct gagaagcctg     2040

agtcctctgt ttcatcagct actggagatg gcaatttgtc tcctagtcag ccacctttaa     2100

agaacctctt gtctctccta aaagcatatt atgctttgaa tgcacaacca agtgcagaag     2160

agctctcaaa aattgctgat tcagtaaacc taccactgga tgtagtaaaa aagtggtttg     2220

aaaagatgca agctggacag atttcagtgc agtcttctga accatcttct cctgaaccag     2280

gcaaagtaaa tatccctgcc aagaacaatg atcagcctca atctgcaaat gcaaatgaac     2340

cccaggacag cacagtaaat ctacaaagtc ctttgaagat gactaactcc ccagttttac     2400

cagtgggatc aaccaccaat ggttccagaa gtagtacacc atccccatca cctctaaacc     2460

tttcctcatc cagaaataca cagggttact tgtacacagc tgagggtgca caagaagagc     2520

cacaagtaga acctcttgat ctttcactac caaagcaaca gggagaatta ttagaaaggt     2580

caactatcac tagtgtttac cagaacagtg tttattctgt ccaggaagaa cccttgaact     2640

tgtcttgcgc aaaaaaggag ccacaaaagg acagttgtgt tacagactca gaaccagttg     2700

taaatgtaat cccaccaagt gccaacccca taaatatcgc tatacctaca gtcactgccc     2760

agttacccac aatcgtggcc attgctgacc agaacagtgt tccatgctta agagcgctag     2820

ctgccaataa gcaaacgatt ctgattcccc aggtggcata cacctactca actacggtca     2880

gccctgcagt ccaagaacca cccttgaaag tgatccagcc aaatggaaat caggatgaaa     2940

gacaagatac tagctcagaa ggagtatcaa atgtagagga tcagaatgac tctgattcta     3000

caccgcccaa aaagaaaatg cggaagacag aaaatggaat gtatgcttgt gatttgtgtg     3060

acaagatatt ccaaaagagt agttcattat tgagacataa atatgaacac acaggtaaaa     3120

gacctcatga gtgtggaatc tgtaaaaagg catttaaaca caaacatcat ttgattgaac     3180

acatgcgatt acattctgga gaaaagccct atcaatgtga caaatgtgga aagcgcttct     3240

cacactctgg gtcttattct caacacatga atcatcgcta ctcctactgt aagagagaag     3300

cggaagaacg tgacagcaca gagcaggaag aggcagggcc tgaaatcctc tcgaatgagc     3360

acgtgggtgc cagggcgtct ccctcacagg gcgactcgga cgagagagag agtttgacaa     3420

gggaagagga tgaagacagt gaaaaagagg aagaggagga ggataaagag atggaagaat     3480

tgcaggaaga aaaagaatgt gaaaaaccac aaggggatga ggaagaggag gaggaggagg     3540

aagaagtgga agaagaagag gtagaagagg cagagaatga gggagaagaa gcaaaaactg     3600

aaggtctgat gaaggatgac agggctgaaa gtcaagcaag cagcttagga caaaaagtag     3660

gcgagagtag tgagcaagtg tctgaagaaa agacaaatga agcctaatcg tttttctaga     3720

aggaaaataa attctaattg ataatgaatt tcgttcaata ttatccttgc ttttcatgga     3780

aacacagtaa cctgtatgct gtgattcctg ttcactactg tgtaaagtaa aaactaaaaa     3840

aatacaaaat acaaaacaca cacacacaca cacacacaca cacacacaca cacacaaaat     3900

aaatccgggt gtgcctgaac ctcagaccta gtaatttttc atgcagtttt caaagttagg     3960

aacaagtttg taacatgcag cagattagaa aaccttaatg actcagagag caacaataca     4020

agaggttaaa ggaagctgat taattagata tgcatctggc attgttttat cttatcagta     4080

ttatcactct tatgttggtt tattcttaag ctgtacaatt gggagaaatt ttataatttt     4140

ttattggtaa acatatgcta aatccgcttc agtattttat tatgtttttt aaaatgtgag     4200

aacttctgca ctacaaaatt cccttcacag agaagtataa tgtagttcca acccgtgcta     4260

actacctttt ataaattcag tctagaaggt agtaatttct aatatttaga tgtcttagta     4320

gagcgtatta tcatttaaag tgtattgtta gccttaagaa agcagctgat agaagaactg     4380

aagtttctta ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga gttctgattg     4440

cagggactaa caatgttaat ctgataagga cagcaaaatc atcagaatca gtgtttgtga     4500

ttgtgtttga atatgtggta acatatgaag gatatgacat gaagctttgt atctcctttg     4560

gccttaagca agacctgtgt gctgtaagtg ccatttctca gtattttcaa ggctctaacc     4620

cgccttcatc caatgtgtgg cctacaataa ctagcatttg ttgatttgtc tcttgtatca     4680

aaattcccaa ataaaactta aaaccactga ctctgtcaga gaaactgaaa cactgggaca     4740

tttcatcctt caattcctcg gtattgattt tatgttgatt gattttcaga atttctctac     4800

agaaacgaaa gggaaatttt ctaatctgct ttatccatgt acttgcattt cagacatgga     4860

catgctattg ttatttggct cataactgtt tccaaatgtt agttattatg gacccaattt     4920

attaacaaca ttagctgatt tttacctatc agtattattt tatttctttt agtttataga     4980

tctgtgcaac atttttgtac tgtatgtctt caaacctggc agtattaata cccttcttac     5040

tgacatatgt acttttagtt ttagaaaact tttatattta tgtgtcttat ttttatattt     5100

ctttatttat tacacagtgt agtgtataat actgtagttt gtattaatac aataatatat     5160

tttagtatga aaatttggaa agttgataag atttaaagta gagatgcaat tggttctcct     5220

gcattgagat ttgatttaac agtgttatgt taacatttat acttgccttg gactgtagaa     5280

cagaacttaa atgggaatgt attagtttta caactacaat caagtcattt tacctttacc     5340

cagtttttaa tataaaactt aaattttgaa attcactgtg tgactaatag catgatgctc     5400

tgcagtttta ttaagaaatc agcctaacca tacaactctc atttccttag taagccaaat     5460

taggattaac ttctataaac agtgttggga acaatgttta acattttgtg ccaatttgtt     5520

cctgtattca tgtatgtaag ttacagatct gactcttcat ttttaagttc cttgttacat     5580

catggtcatt ttctagtttt ttaccagact cccatctcac aataaaatgc atcaacaagc     5640

ctgaactgct gtcattcttt tcatcattat cagtattttc tttggaaaac tgtgaaatgg     5700

ggtacattgt catcctgcat ttgattcatc ttgagctgaa tttgggtaac actaaatgtt     5760

ttagacattc tccactaaat tatggatttt cttgtggcta aatgtttctg gagaggtcag     5820

agttgacaaa acctcttcac aggttgctcc ttcttcctga aatccttaat cctccgcatt     5880

tcatgcttca ggtcatttca gggaagcctg ggtttagatg cctttctgac tctcagctcc     5940

tgcacttctg tcatcatacc tctgatacta ttatttatat tccttcccca ctaggaacag     6000

gaaccacatt tgtcatagtc actctcacat tcctcactgc ctaacagggt gcctggcata     6060

agttgggaca acagatattt gttgaataaa aatataattt gcatgtttat ggagctcagc     6120

tatgttctca ctttttttgc ttctaattcc agaatatatg ttaaatgatc taataatttg     6180

attattttct tataagtctt attaaacact agtcataata gacacaataa attatgcctt     6240

ctttttc                                                               6247


<210> 100
<211> 906
<212> PRT
<213> Homo sapiens

<400> 100
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 101
<211> 6192
<212> DNA
<213> Homo sapiens

<400> 101
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc aggacaacct taaacttcca ccacaagagg aatataaaga ggtccctcct      240

gcaccaagaa agatctgcag atctttttca gtgttcttgg aggtgtgggg tgtgagaact      300

tgatcagttt gtgtcagcca ccttgttctc taaagttaca aattataata ctgtggtaga      360

aacaaattca gattcagatg atgaagacaa actgcatatt gtggaagaag aaagtgttac      420

agatgcagct gactgtgaag gtgtaccaga ggatgacctg ccaacagacc agacagtgtt      480

accagggagg agcagtgaaa gagaagggaa tgctaagaac tgctgggagg atgacagaaa      540

ggaagggcaa gaaatcctgg ggcctgaagc tcaggcagat gaagcaggat gtacagtaaa      600

agatgatgaa tgcgagtcag atgcagaaaa tgagcaaaac catgatccta atgttgaaga      660

gtttctacaa caacaagaca ctgctgtcat ttttcctgag gcacctgaag aggaccagag      720

gcagggcaca ccagaagcca gtggtcatga tgaaaatgga acaccagatg cattttcaca      780

attactcacc tgtccatatt gtgatagagg ctataaacgc tttacctctc tgaaagaaca      840

cattaaatat cgtcatgaaa agaatgaaga taactttagt tgctccctgt gcagttacac      900

ctttgcatac agaacccaac ttgaacgtca catgacatca cataaatcag gaagagatca      960

aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc     1020

tttcaaatac aaacatcacc taaaagagca cttaagaatt cacagtggag agaagccata     1080

tgaatgccca aactgcaaga aacgcttttc ccattctggc tcctatagct cacacataag     1140

cagtaagaaa tgtatcagct tgatacctgt gaatgggcga ccaagaacag gactcaagac     1200

atctcagtgt tcttcaccgt ctctttcagc atcaccaggc agtcccacac gaccacagat     1260

acggcaaaag atagagaata aaccccttca agaacaactt tctgttaacc aaattaaaac     1320

tgaacctgtg gattatgaat tcaaacccat agtggttgct tcaggaatca actgttcaac     1380

ccctttacaa aatggggttt tcactggtgg tggcccatta caggcaacca gttctcctca     1440

gggcatggtg caagctgttg ttctgccaac agttggtttg gtgtctccca taagtatcaa     1500

tttaagtgat attcagaatg tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt     1560

gttggagaat aatcaagcca atcttgcatc caaagaacaa gaaacaatca atgcttcacc     1620

catacaacaa ggtggccatt ctgttatttc agccatcagt cttcctttgg ttgatcaaga     1680

tggaacaacc aaaattatca tcaactacag tcttgagcag cctagccaac ttcaagttgt     1740

tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt     1800

accagaagat cttactgtta agtctgagaa ggacaaaagc tttgaagggg gggtgaatga     1860

tagcacttgt cttctgtgtg atgattgtcc aggagatatt aatgcacttc cagaattaaa     1920

gcactatgac ctaaagcagc ctactcagcc tcctccactc cctgcagcag aagctgagaa     1980

gcctgagtcc tctgtttcat cagctactgg agatggcaat ttgtctccta gtcagccacc     2040

tttaaagaac ctcttgtctc tcctaaaagc atattatgct ttgaatgcac aaccaagtgc     2100

agaagagctc tcaaaaattg ctgattcagt aaacctacca ctggatgtag taaaaaagtg     2160

gtttgaaaag atgcaagctg gacagatttc agtgcagtct tctgaaccat cttctcctga     2220

accaggcaaa gtaaatatcc ctgccaagaa caatgatcag cctcaatctg caaatgcaaa     2280

tgaaccccag gacagcacag taaatctaca aagtcctttg aagatgacta actccccagt     2340

tttaccagtg ggatcaacca ccaatggttc cagaagtagt acaccatccc catcacctct     2400

aaacctttcc tcatccagaa atacacaggg ttacttgtac acagctgagg gtgcacaaga     2460

agagccacaa gtagaacctc ttgatctttc actaccaaag caacagggag aattattaga     2520

aaggtcaact atcactagtg tttaccagaa cagtgtttat tctgtccagg aagaaccctt     2580

gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt tgtgttacag actcagaacc     2640

agttgtaaat gtaatcccac caagtgccaa ccccataaat atcgctatac ctacagtcac     2700

tgcccagtta cccacaatcg tggccattgc tgaccagaac agtgttccat gcttaagagc     2760

gctagctgcc aataagcaaa cgattctgat tccccaggtg gcatacacct actcaactac     2820

ggtcagccct gcagtccaag aaccaccctt gaaagtgatc cagccaaatg gaaatcagga     2880

tgaaagacaa gatactagct cagaaggagt atcaaatgta gaggatcaga atgactctga     2940

ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt     3000

gtgtgacaag atattccaaa agagtagttc attattgaga cataaatatg aacacacagg     3060

taaaagacct catgagtgtg gaatctgtaa aaaggcattt aaacacaaac atcatttgat     3120

tgaacacatg cgattacatt ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg     3180

cttctcacac tctgggtctt attctcaaca catgaatcat cgctactcct actgtaagag     3240

agaagcggaa gaacgtgaca gcacagagca ggaagaggca gggcctgaaa tcctctcgaa     3300

tgagcacgtg ggtgccaggg cgtctccctc acagggcgac tcggacgaga gagagagttt     3360

gacaagggaa gaggatgaag acagtgaaaa agaggaagag gaggaggata aagagatgga     3420

agaattgcag gaagaaaaag aatgtgaaaa accacaaggg gatgaggaag aggaggagga     3480

ggaggaagaa gtggaagaag aagaggtaga agaggcagag aatgagggag aagaagcaaa     3540

aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa gcaagcagct taggacaaaa     3600

agtaggcgag agtagtgagc aagtgtctga agaaaagaca aatgaagcct aatcgttttt     3660

ctagaaggaa aataaattct aattgataat gaatttcgtt caatattatc cttgcttttc     3720

atggaaacac agtaacctgt atgctgtgat tcctgttcac tactgtgtaa agtaaaaact     3780

aaaaaaatac aaaatacaaa acacacacac acacacacac acacacacac acacacacac     3840

aaaataaatc cgggtgtgcc tgaacctcag acctagtaat ttttcatgca gttttcaaag     3900

ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct taatgactca gagagcaaca     3960

atacaagagg ttaaaggaag ctgattaatt agatatgcat ctggcattgt tttatcttat     4020

cagtattatc actcttatgt tggtttattc ttaagctgta caattgggag aaattttata     4080

attttttatt ggtaaacata tgctaaatcc gcttcagtat tttattatgt tttttaaaat     4140

gtgagaactt ctgcactaca aaattccctt cacagagaag tataatgtag ttccaacccg     4200

tgctaactac cttttataaa ttcagtctag aaggtagtaa tttctaatat ttagatgtct     4260

tagtagagcg tattatcatt taaagtgtat tgttagcctt aagaaagcag ctgatagaag     4320

aactgaagtt tcttactcac gtggtttaaa atggagttca aaagattgcc attgagttct     4380

gattgcaggg actaacaatg ttaatctgat aaggacagca aaatcatcag aatcagtgtt     4440

tgtgattgtg tttgaatatg tggtaacata tgaaggatat gacatgaagc tttgtatctc     4500

ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc     4560

taacccgcct tcatccaatg tgtggcctac aataactagc atttgttgat ttgtctcttg     4620

tatcaaaatt cccaaataaa acttaaaacc actgactctg tcagagaaac tgaaacactg     4680

ggacatttca tccttcaatt cctcggtatt gattttatgt tgattgattt tcagaatttc     4740

tctacagaaa cgaaagggaa attttctaat ctgctttatc catgtacttg catttcagac     4800

atggacatgc tattgttatt tggctcataa ctgtttccaa atgttagtta ttatggaccc     4860

aatttattaa caacattagc tgatttttac ctatcagtat tattttattt cttttagttt     4920

atagatctgt gcaacatttt tgtactgtat gtcttcaaac ctggcagtat taataccctt     4980

cttactgaca tatgtacttt tagttttaga aaacttttat atttatgtgt cttattttta     5040

tatttcttta tttattacac agtgtagtgt ataatactgt agtttgtatt aatacaataa     5100

tatattttag tatgaaaatt tggaaagttg ataagattta aagtagagat gcaattggtt     5160

ctcctgcatt gagatttgat ttaacagtgt tatgttaaca tttatacttg ccttggactg     5220

tagaacagaa cttaaatggg aatgtattag ttttacaact acaatcaagt cattttacct     5280

ttacccagtt tttaatataa aacttaaatt ttgaaattca ctgtgtgact aatagcatga     5340

tgctctgcag ttttattaag aaatcagcct aaccatacaa ctctcatttc cttagtaagc     5400

caaattagga ttaacttcta taaacagtgt tgggaacaat gtttaacatt ttgtgccaat     5460

ttgttcctgt attcatgtat gtaagttaca gatctgactc ttcattttta agttccttgt     5520

tacatcatgg tcattttcta gttttttacc agactcccat ctcacaataa aatgcatcaa     5580

caagcctgaa ctgctgtcat tcttttcatc attatcagta ttttctttgg aaaactgtga     5640

aatggggtac attgtcatcc tgcatttgat tcatcttgag ctgaatttgg gtaacactaa     5700

atgttttaga cattctccac taaattatgg attttcttgt ggctaaatgt ttctggagag     5760

gtcagagttg acaaaacctc ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc     5820

gcatttcatg cttcaggtca tttcagggaa gcctgggttt agatgccttt ctgactctca     5880

gctcctgcac ttctgtcatc atacctctga tactattatt tatattcctt ccccactagg     5940

aacaggaacc acatttgtca tagtcactct cacattcctc actgcctaac agggtgcctg     6000

gcataagttg ggacaacaga tatttgttga ataaaaatat aatttgcatg tttatggagc     6060

tcagctatgt tctcactttt tttgcttcta attccagaat atatgttaaa tgatctaata     6120

atttgattat tttcttataa gtcttattaa acactagtca taatagacac aataaattat     6180

gccttctttt tc                                                         6192


<210> 102
<211> 906
<212> PRT
<213> Homo sapiens

<400> 102
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 103
<211> 5712
<212> DNA
<213> Homo sapiens

<400> 103
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgtta caaattataa tactgtggta gaaacaaatt cagattcaga      120

tgatgaagac aaactgcata ttgtggaaga agaaagtgtt acagatgcag ctgactgtga      180

aggtgtacca gaggatgacc tgccaacaga ccagacagtg ttaccaggga ggagcagtga      240

aagagaaggg aatgctaaga actgctggga ggatgacaga acaccagatg cattttcaca      300

attactcacc tgtccatatt gtgatagagg ctataaacgc tttacctctc tgaaagaaca      360

cattaaatat cgtcatgaaa agaatgaaga taactttagt tgctccctgt gcagttacac      420

ctttgcatac agaacccaac ttgaacgtca catgacatca cataaatcag gaagagatca      480

aagacatgtg acgcagtctg ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc      540

tttcaaatac aaacatcacc taaaagagca cttaagaatt cacagtggag agaagccata      600

tgaatgccca aactgcaaga aacgcttttc ccattctggc tcctatagct cacacataag      660

cagtaagaaa tgtatcagct tgatacctgt gaatgggcga ccaagaacag gactcaagac      720

atctcagtgt tcttcaccgt ctctttcagc atcaccaggc agtcccacac gaccacagat      780

acggcaaaag atagagaata aaccccttca agaacaactt tctgttaacc aaattaaaac      840

tgaacctgtg gattatgaat tcaaacccat agtggttgct tcaggaatca actgttcaac      900

ccctttacaa aatggggttt tcactggtgg tggcccatta caggcaacca gttctcctca      960

gggcatggtg caagctgttg ttctgccaac agttggtttg gtgtctccca taagtatcaa     1020

tttaagtgat attcagaatg tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt     1080

gttggagaat aatcaagcca atcttgcatc caaagaacaa gaaacaatca atgcttcacc     1140

catacaacaa ggtggccatt ctgttatttc agccatcagt cttcctttgg ttgatcaaga     1200

tggaacaacc aaaattatca tcaactacag tcttgagcag cctagccaac ttcaagttgt     1260

tcctcaaaat ttaaaaaaag aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt     1320

accagaagat cttactgtta agtctgagaa ggacaaaagc tttgaagggg gggtgaatga     1380

tagcacttgt cttctgtgtg atgattgtcc aggagatatt aatgcacttc cagaattaaa     1440

gcactatgac ctaaagcagc ctactcagcc tcctccactc cctgcagcag aagctgagaa     1500

gcctgagtcc tctgtttcat cagctactgg agatggcaat ttgtctccta gtcagccacc     1560

tttaaagaac ctcttgtctc tcctaaaagc atattatgct ttgaatgcac aaccaagtgc     1620

agaagagctc tcaaaaattg ctgattcagt aaacctacca ctggatgtag taaaaaagtg     1680

gtttgaaaag atgcaagctg gacagatttc agtgcagtct tctgaaccat cttctcctga     1740

accaggcaaa gtaaatatcc ctgccaagaa caatgatcag cctcaatctg caaatgcaaa     1800

tgaaccccag gacagcacag taaatctaca aagtcctttg aagatgacta actccccagt     1860

tttaccagtg ggatcaacca ccaatggttc cagaagtagt acaccatccc catcacctct     1920

aaacctttcc tcatccagaa atacacaggg ttacttgtac acagctgagg gtgcacaaga     1980

agagccacaa gtagaacctc ttgatctttc actaccaaag caacagggag aattattaga     2040

aaggtcaact atcactagtg tttaccagaa cagtgtttat tctgtccagg aagaaccctt     2100

gaacttgtct tgcgcaaaaa aggagccaca aaaggacagt tgtgttacag actcagaacc     2160

agttgtaaat gtaatcccac caagtgccaa ccccataaat atcgctatac ctacagtcac     2220

tgcccagtta cccacaatcg tggccattgc tgaccagaac agtgttccat gcttaagagc     2280

gctagctgcc aataagcaaa cgattctgat tccccaggtg gcatacacct actcaactac     2340

ggtcagccct gcagtccaag aaccaccctt gaaagtgatc cagccaaatg gaaatcagga     2400

tgaaagacaa gatactagct cagaaggagt atcaaatgta gaggatcaga atgactctga     2460

ttctacaccg cccaaaaaga aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt     2520

gtgtgacaag atattccaaa agagtagttc attattgaga cataaatatg aacacacagg     2580

taaaagacct catgagtgtg gaatctgtaa aaaggcattt aaacacaaac atcatttgat     2640

tgaacacatg cgattacatt ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg     2700

cttctcacac tctgggtctt attctcaaca catgaatcat cgctactcct actgtaagag     2760

agaagcggaa gaacgtgaca gcacagagca ggaagaggca gggcctgaaa tcctctcgaa     2820

tgagcacgtg ggtgccaggg cgtctccctc acagggcgac tcggacgaga gagagagttt     2880

gacaagggaa gaggatgaag acagtgaaaa agaggaagag gaggaggata aagagatgga     2940

agaattgcag gaagaaaaag aatgtgaaaa accacaaggg gatgaggaag aggaggagga     3000

ggaggaagaa gtggaagaag aagaggtaga agaggcagag aatgagggag aagaagcaaa     3060

aactgaaggt ctgatgaagg atgacagggc tgaaagtcaa gcaagcagct taggacaaaa     3120

agtaggcgag agtagtgagc aagtgtctga agaaaagaca aatgaagcct aatcgttttt     3180

ctagaaggaa aataaattct aattgataat gaatttcgtt caatattatc cttgcttttc     3240

atggaaacac agtaacctgt atgctgtgat tcctgttcac tactgtgtaa agtaaaaact     3300

aaaaaaatac aaaatacaaa acacacacac acacacacac acacacacac acacacacac     3360

aaaataaatc cgggtgtgcc tgaacctcag acctagtaat ttttcatgca gttttcaaag     3420

ttaggaacaa gtttgtaaca tgcagcagat tagaaaacct taatgactca gagagcaaca     3480

atacaagagg ttaaaggaag ctgattaatt agatatgcat ctggcattgt tttatcttat     3540

cagtattatc actcttatgt tggtttattc ttaagctgta caattgggag aaattttata     3600

attttttatt ggtaaacata tgctaaatcc gcttcagtat tttattatgt tttttaaaat     3660

gtgagaactt ctgcactaca aaattccctt cacagagaag tataatgtag ttccaacccg     3720

tgctaactac cttttataaa ttcagtctag aaggtagtaa tttctaatat ttagatgtct     3780

tagtagagcg tattatcatt taaagtgtat tgttagcctt aagaaagcag ctgatagaag     3840

aactgaagtt tcttactcac gtggtttaaa atggagttca aaagattgcc attgagttct     3900

gattgcaggg actaacaatg ttaatctgat aaggacagca aaatcatcag aatcagtgtt     3960

tgtgattgtg tttgaatatg tggtaacata tgaaggatat gacatgaagc tttgtatctc     4020

ctttggcctt aagcaagacc tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc     4080

taacccgcct tcatccaatg tgtggcctac aataactagc atttgttgat ttgtctcttg     4140

tatcaaaatt cccaaataaa acttaaaacc actgactctg tcagagaaac tgaaacactg     4200

ggacatttca tccttcaatt cctcggtatt gattttatgt tgattgattt tcagaatttc     4260

tctacagaaa cgaaagggaa attttctaat ctgctttatc catgtacttg catttcagac     4320

atggacatgc tattgttatt tggctcataa ctgtttccaa atgttagtta ttatggaccc     4380

aatttattaa caacattagc tgatttttac ctatcagtat tattttattt cttttagttt     4440

atagatctgt gcaacatttt tgtactgtat gtcttcaaac ctggcagtat taataccctt     4500

cttactgaca tatgtacttt tagttttaga aaacttttat atttatgtgt cttattttta     4560

tatttcttta tttattacac agtgtagtgt ataatactgt agtttgtatt aatacaataa     4620

tatattttag tatgaaaatt tggaaagttg ataagattta aagtagagat gcaattggtt     4680

ctcctgcatt gagatttgat ttaacagtgt tatgttaaca tttatacttg ccttggactg     4740

tagaacagaa cttaaatggg aatgtattag ttttacaact acaatcaagt cattttacct     4800

ttacccagtt tttaatataa aacttaaatt ttgaaattca ctgtgtgact aatagcatga     4860

tgctctgcag ttttattaag aaatcagcct aaccatacaa ctctcatttc cttagtaagc     4920

caaattagga ttaacttcta taaacagtgt tgggaacaat gtttaacatt ttgtgccaat     4980

ttgttcctgt attcatgtat gtaagttaca gatctgactc ttcattttta agttccttgt     5040

tacatcatgg tcattttcta gttttttacc agactcccat ctcacaataa aatgcatcaa     5100

caagcctgaa ctgctgtcat tcttttcatc attatcagta ttttctttgg aaaactgtga     5160

aatggggtac attgtcatcc tgcatttgat tcatcttgag ctgaatttgg gtaacactaa     5220

atgttttaga cattctccac taaattatgg attttcttgt ggctaaatgt ttctggagag     5280

gtcagagttg acaaaacctc ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc     5340

gcatttcatg cttcaggtca tttcagggaa gcctgggttt agatgccttt ctgactctca     5400

gctcctgcac ttctgtcatc atacctctga tactattatt tatattcctt ccccactagg     5460

aacaggaacc acatttgtca tagtcactct cacattcctc actgcctaac agggtgcctg     5520

gcataagttg ggacaacaga tatttgttga ataaaaatat aatttgcatg tttatggagc     5580

tcagctatgt tctcactttt tttgcttcta attccagaat atatgttaaa tgatctaata     5640

atttgattat tttcttataa gtcttattaa acactagtca taatagacac aataaattat     5700

gccttctttt tc                                                         5712


<210> 104
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 104
Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys Gln Ala Asn Pro Arg 
1               5                   10                  15      


Arg Asn Asn Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp 
            20                  25                  30          


Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr 
        35                  40                  45              


Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp 
    50                  55                  60                  


Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys 
65                  70                  75                  80  


Asn Cys Trp Glu Asp Asp Arg Thr Pro Asp Ala Phe Ser Gln Leu Leu 
                85                  90                  95      


Thr Cys Pro Tyr Cys Asp Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys 
            100                 105                 110         


Glu His Ile Lys Tyr Arg His Glu Lys Asn Glu Asp Asn Phe Ser Cys 
        115                 120                 125             


Ser Leu Cys Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu Glu Arg His 
    130                 135                 140                 


Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
145                 150                 155                 160 


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
                165                 170                 175     


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
            180                 185                 190         


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
        195                 200                 205             


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
    210                 215                 220                 


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
225                 230                 235                 240 


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
                245                 250                 255     


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
            260                 265                 270         


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
        275                 280                 285             


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
    290                 295                 300                 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
305                 310                 315                 320 


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
                325                 330                 335     


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
            340                 345                 350         


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
        355                 360                 365             


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
    370                 375                 380                 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
385                 390                 395                 400 


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
                405                 410                 415     


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
            420                 425                 430         


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
        435                 440                 445             


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
    450                 455                 460                 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
465                 470                 475                 480 


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
                485                 490                 495     


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
            500                 505                 510         


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
        515                 520                 525             


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
    530                 535                 540                 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
545                 550                 555                 560 


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
                565                 570                 575     


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
            580                 585                 590         


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
        595                 600                 605             


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
    610                 615                 620                 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
625                 630                 635                 640 


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
                645                 650                 655     


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
            660                 665                 670         


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
        675                 680                 685             


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
    690                 695                 700                 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
705                 710                 715                 720 


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
                725                 730                 735     


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
            740                 745                 750         


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
        755                 760                 765             


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
    770                 775                 780                 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
785                 790                 795                 800 


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
                805                 810                 815     


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
            820                 825                 830         


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
        835                 840                 845             


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
    850                 855                 860                 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
865                 870                 875                 880 


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
                885                 890                 895     


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
            900                 905                 910         


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
        915                 920                 925             


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
    930                 935                 940                 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
945                 950                 955                 960 


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
                965                 970                 975     


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
            980                 985                 990         


Glu Glu Glu Glu Glu Val Glu Glu  Glu Glu Val Glu Glu  Ala Glu Asn 
        995                 1000                 1005             


Glu Gly  Glu Glu Ala Lys Thr  Glu Gly Leu Met Lys  Asp Asp Arg 
    1010                 1015                 1020             


Ala Glu  Ser Gln Ala Ser Ser  Leu Gly Gln Lys Val  Gly Glu Ser 
    1025                 1030                 1035             


Ser Glu  Gln Val Ser Glu Glu  Lys Thr Asn Glu Ala  
    1040                 1045                 1050 


<210> 105
<211> 5827
<212> DNA
<213> Homo sapiens

<400> 105
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc agttacaaat tataatactg tggtagaaac aaattcagat tcagatgatg      240

aagacaaact gcatattgtg gaagaagaaa gtgttacaga tgcagctgac tgtgaaggtg      300

taccagagga tgacctgcca acagaccaga cagtgttacc agggaggagc agtgaaagag      360

aagggaatgc taagaactgc tgggaggatg acagaacacc agatgcattt tcacaattac      420

tcacctgtcc atattgtgat agaggctata aacgctttac ctctctgaaa gaacacatta      480

aatatcgtca tgaaaagaat gaagataact ttagttgctc cctgtgcagt tacacctttg      540

catacagaac ccaacttgaa cgtcacatga catcacataa atcaggaaga gatcaaagac      600

atgtgacgca gtctgggtgt aatcgtaaat tcaaatgcac tgagtgtgga aaagctttca      660

aatacaaaca tcacctaaaa gagcacttaa gaattcacag tggagagaag ccatatgaat      720

gcccaaactg caagaaacgc ttttcccatt ctggctccta tagctcacac ataagcagta      780

agaaatgtat cagcttgata cctgtgaatg ggcgaccaag aacaggactc aagacatctc      840

agtgttcttc accgtctctt tcagcatcac caggcagtcc cacacgacca cagatacggc      900

aaaagataga gaataaaccc cttcaagaac aactttctgt taaccaaatt aaaactgaac      960

ctgtggatta tgaattcaaa cccatagtgg ttgcttcagg aatcaactgt tcaacccctt     1020

tacaaaatgg ggttttcact ggtggtggcc cattacaggc aaccagttct cctcagggca     1080

tggtgcaagc tgttgttctg ccaacagttg gtttggtgtc tcccataagt atcaatttaa     1140

gtgatattca gaatgtactt aaagtggcgg tagatggtaa tgtaataagg caagtgttgg     1200

agaataatca agccaatctt gcatccaaag aacaagaaac aatcaatgct tcacccatac     1260

aacaaggtgg ccattctgtt atttcagcca tcagtcttcc tttggttgat caagatggaa     1320

caaccaaaat tatcatcaac tacagtcttg agcagcctag ccaacttcaa gttgttcctc     1380

aaaatttaaa aaaagaaaat ccagtcgcta caaacagttg taaaagtgaa aagttaccag     1440

aagatcttac tgttaagtct gagaaggaca aaagctttga agggggggtg aatgatagca     1500

cttgtcttct gtgtgatgat tgtccaggag atattaatgc acttccagaa ttaaagcact     1560

atgacctaaa gcagcctact cagcctcctc cactccctgc agcagaagct gagaagcctg     1620

agtcctctgt ttcatcagct actggagatg gcaatttgtc tcctagtcag ccacctttaa     1680

agaacctctt gtctctccta aaagcatatt atgctttgaa tgcacaacca agtgcagaag     1740

agctctcaaa aattgctgat tcagtaaacc taccactgga tgtagtaaaa aagtggtttg     1800

aaaagatgca agctggacag atttcagtgc agtcttctga accatcttct cctgaaccag     1860

gcaaagtaaa tatccctgcc aagaacaatg atcagcctca atctgcaaat gcaaatgaac     1920

cccaggacag cacagtaaat ctacaaagtc ctttgaagat gactaactcc ccagttttac     1980

cagtgggatc aaccaccaat ggttccagaa gtagtacacc atccccatca cctctaaacc     2040

tttcctcatc cagaaataca cagggttact tgtacacagc tgagggtgca caagaagagc     2100

cacaagtaga acctcttgat ctttcactac caaagcaaca gggagaatta ttagaaaggt     2160

caactatcac tagtgtttac cagaacagtg tttattctgt ccaggaagaa cccttgaact     2220

tgtcttgcgc aaaaaaggag ccacaaaagg acagttgtgt tacagactca gaaccagttg     2280

taaatgtaat cccaccaagt gccaacccca taaatatcgc tatacctaca gtcactgccc     2340

agttacccac aatcgtggcc attgctgacc agaacagtgt tccatgctta agagcgctag     2400

ctgccaataa gcaaacgatt ctgattcccc aggtggcata cacctactca actacggtca     2460

gccctgcagt ccaagaacca cccttgaaag tgatccagcc aaatggaaat caggatgaaa     2520

gacaagatac tagctcagaa ggagtatcaa atgtagagga tcagaatgac tctgattcta     2580

caccgcccaa aaagaaaatg cggaagacag aaaatggaat gtatgcttgt gatttgtgtg     2640

acaagatatt ccaaaagagt agttcattat tgagacataa atatgaacac acaggtaaaa     2700

gacctcatga gtgtggaatc tgtaaaaagg catttaaaca caaacatcat ttgattgaac     2760

acatgcgatt acattctgga gaaaagccct atcaatgtga caaatgtgga aagcgcttct     2820

cacactctgg gtcttattct caacacatga atcatcgcta ctcctactgt aagagagaag     2880

cggaagaacg tgacagcaca gagcaggaag aggcagggcc tgaaatcctc tcgaatgagc     2940

acgtgggtgc cagggcgtct ccctcacagg gcgactcgga cgagagagag agtttgacaa     3000

gggaagagga tgaagacagt gaaaaagagg aagaggagga ggataaagag atggaagaat     3060

tgcaggaaga aaaagaatgt gaaaaaccac aaggggatga ggaagaggag gaggaggagg     3120

aagaagtgga agaagaagag gtagaagagg cagagaatga gggagaagaa gcaaaaactg     3180

aaggtctgat gaaggatgac agggctgaaa gtcaagcaag cagcttagga caaaaagtag     3240

gcgagagtag tgagcaagtg tctgaagaaa agacaaatga agcctaatcg tttttctaga     3300

aggaaaataa attctaattg ataatgaatt tcgttcaata ttatccttgc ttttcatgga     3360

aacacagtaa cctgtatgct gtgattcctg ttcactactg tgtaaagtaa aaactaaaaa     3420

aatacaaaat acaaaacaca cacacacaca cacacacaca cacacacaca cacacaaaat     3480

aaatccgggt gtgcctgaac ctcagaccta gtaatttttc atgcagtttt caaagttagg     3540

aacaagtttg taacatgcag cagattagaa aaccttaatg actcagagag caacaataca     3600

agaggttaaa ggaagctgat taattagata tgcatctggc attgttttat cttatcagta     3660

ttatcactct tatgttggtt tattcttaag ctgtacaatt gggagaaatt ttataatttt     3720

ttattggtaa acatatgcta aatccgcttc agtattttat tatgtttttt aaaatgtgag     3780

aacttctgca ctacaaaatt cccttcacag agaagtataa tgtagttcca acccgtgcta     3840

actacctttt ataaattcag tctagaaggt agtaatttct aatatttaga tgtcttagta     3900

gagcgtatta tcatttaaag tgtattgtta gccttaagaa agcagctgat agaagaactg     3960

aagtttctta ctcacgtggt ttaaaatgga gttcaaaaga ttgccattga gttctgattg     4020

cagggactaa caatgttaat ctgataagga cagcaaaatc atcagaatca gtgtttgtga     4080

ttgtgtttga atatgtggta acatatgaag gatatgacat gaagctttgt atctcctttg     4140

gccttaagca agacctgtgt gctgtaagtg ccatttctca gtattttcaa ggctctaacc     4200

cgccttcatc caatgtgtgg cctacaataa ctagcatttg ttgatttgtc tcttgtatca     4260

aaattcccaa ataaaactta aaaccactga ctctgtcaga gaaactgaaa cactgggaca     4320

tttcatcctt caattcctcg gtattgattt tatgttgatt gattttcaga atttctctac     4380

agaaacgaaa gggaaatttt ctaatctgct ttatccatgt acttgcattt cagacatgga     4440

catgctattg ttatttggct cataactgtt tccaaatgtt agttattatg gacccaattt     4500

attaacaaca ttagctgatt tttacctatc agtattattt tatttctttt agtttataga     4560

tctgtgcaac atttttgtac tgtatgtctt caaacctggc agtattaata cccttcttac     4620

tgacatatgt acttttagtt ttagaaaact tttatattta tgtgtcttat ttttatattt     4680

ctttatttat tacacagtgt agtgtataat actgtagttt gtattaatac aataatatat     4740

tttagtatga aaatttggaa agttgataag atttaaagta gagatgcaat tggttctcct     4800

gcattgagat ttgatttaac agtgttatgt taacatttat acttgccttg gactgtagaa     4860

cagaacttaa atgggaatgt attagtttta caactacaat caagtcattt tacctttacc     4920

cagtttttaa tataaaactt aaattttgaa attcactgtg tgactaatag catgatgctc     4980

tgcagtttta ttaagaaatc agcctaacca tacaactctc atttccttag taagccaaat     5040

taggattaac ttctataaac agtgttggga acaatgttta acattttgtg ccaatttgtt     5100

cctgtattca tgtatgtaag ttacagatct gactcttcat ttttaagttc cttgttacat     5160

catggtcatt ttctagtttt ttaccagact cccatctcac aataaaatgc atcaacaagc     5220

ctgaactgct gtcattcttt tcatcattat cagtattttc tttggaaaac tgtgaaatgg     5280

ggtacattgt catcctgcat ttgattcatc ttgagctgaa tttgggtaac actaaatgtt     5340

ttagacattc tccactaaat tatggatttt cttgtggcta aatgtttctg gagaggtcag     5400

agttgacaaa acctcttcac aggttgctcc ttcttcctga aatccttaat cctccgcatt     5460

tcatgcttca ggtcatttca gggaagcctg ggtttagatg cctttctgac tctcagctcc     5520

tgcacttctg tcatcatacc tctgatacta ttatttatat tccttcccca ctaggaacag     5580

gaaccacatt tgtcatagtc actctcacat tcctcactgc ctaacagggt gcctggcata     5640

agttgggaca acagatattt gttgaataaa aatataattt gcatgtttat ggagctcagc     5700

tatgttctca ctttttttgc ttctaattcc agaatatatg ttaaatgatc taataatttg     5760

attattttct tataagtctt attaaacact agtcataata gacacaataa attatgcctt     5820

ctttttc                                                               5827


<210> 106
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 106
Met Ala Thr Cys Ala Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn 
1               5                   10                  15      


Ser Asp Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser 
            20                  25                  30          


Val Thr Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro 
        35                  40                  45              


Thr Asp Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn 
    50                  55                  60                  


Ala Lys Asn Cys Trp Glu Asp Asp Arg Thr Pro Asp Ala Phe Ser Gln 
65                  70                  75                  80  


Leu Leu Thr Cys Pro Tyr Cys Asp Arg Gly Tyr Lys Arg Phe Thr Ser 
                85                  90                  95      


Leu Lys Glu His Ile Lys Tyr Arg His Glu Lys Asn Glu Asp Asn Phe 
            100                 105                 110         


Ser Cys Ser Leu Cys Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu Glu 
        115                 120                 125             


Arg His Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr 
    130                 135                 140                 


Gln Ser Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala 
145                 150                 155                 160 


Phe Lys Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly 
                165                 170                 175     


Glu Lys Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser 
            180                 185                 190         


Gly Ser Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile 
        195                 200                 205             


Pro Val Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser 
    210                 215                 220                 


Ser Pro Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile 
225                 230                 235                 240 


Arg Gln Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn 
                245                 250                 255     


Gln Ile Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val 
            260                 265                 270         


Ala Ser Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr 
        275                 280                 285             


Gly Gly Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln 
    290                 295                 300                 


Ala Val Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn 
305                 310                 315                 320 


Leu Ser Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val 
                325                 330                 335     


Ile Arg Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu 
            340                 345                 350         


Gln Glu Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val 
        355                 360                 365             


Ile Ser Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys 
    370                 375                 380                 


Ile Ile Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val 
385                 390                 395                 400 


Pro Gln Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys 
                405                 410                 415     


Ser Glu Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys 
            420                 425                 430         


Ser Phe Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp 
        435                 440                 445             


Cys Pro Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu 
    450                 455                 460                 


Lys Gln Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys 
465                 470                 475                 480 


Pro Glu Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro 
                485                 490                 495     


Ser Gln Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr 
            500                 505                 510         


Ala Leu Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp 
        515                 520                 525             


Ser Val Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met 
    530                 535                 540                 


Gln Ala Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu 
545                 550                 555                 560 


Pro Gly Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser 
                565                 570                 575     


Ala Asn Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro 
            580                 585                 590         


Leu Lys Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn 
        595                 600                 605             


Gly Ser Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser 
    610                 615                 620                 


Ser Arg Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu 
625                 630                 635                 640 


Glu Pro Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly 
                645                 650                 655     


Glu Leu Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val 
            660                 665                 670         


Tyr Ser Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu 
        675                 680                 685             


Pro Gln Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val 
    690                 695                 700                 


Ile Pro Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr 
705                 710                 715                 720 


Ala Gln Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro 
                725                 730                 735     


Cys Leu Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln 
            740                 745                 750         


Val Ala Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro 
        755                 760                 765             


Pro Leu Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp 
    770                 775                 780                 


Thr Ser Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp 
785                 790                 795                 800 


Ser Thr Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr 
                805                 810                 815     


Ala Cys Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu 
            820                 825                 830         


Arg His Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile 
        835                 840                 845             


Cys Lys Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg 
    850                 855                 860                 


Leu His Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg 
865                 870                 875                 880 


Phe Ser His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser 
                885                 890                 895     


Tyr Cys Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu 
            900                 905                 910         


Ala Gly Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser 
        915                 920                 925             


Pro Ser Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu 
    930                 935                 940                 


Asp Glu Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu 
945                 950                 955                 960 


Glu Leu Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu 
                965                 970                 975     


Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala 
            980                 985                 990         


Glu Asn Glu Gly Glu Glu Ala Lys  Thr Glu Gly Leu Met  Lys Asp Asp 
        995                 1000                 1005             


Arg Ala  Glu Ser Gln Ala Ser  Ser Leu Gly Gln Lys  Val Gly Glu 
    1010                 1015                 1020             


Ser Ser  Glu Gln Val Ser Glu  Glu Lys Thr Asn Glu  Ala 
    1025                 1030                 1035     


<210> 107
<211> 6052
<212> DNA
<213> Homo sapiens

<400> 107
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc agttacaaat tataatactg tggtagaaac aaattcagat tcagatgatg      240

aagacaaact gcatattgtg gaagaagaaa gtgttacaga tgcagctgac tgtgaaggtg      300

taccagagga tgacctgcca acagaccaga cagtgttacc agggaggagc agtgaaagag      360

aagggaatgc taagaactgc tgggaggatg acacaggaaa ggaagggcaa gaaatcctgg      420

ggcctgaagc tcaggcagat gaagcaggat gtacagtaaa agatgatgaa tgcgagtcag      480

atgcagaaaa tgagcaaaac catgatccta atgttgaaga gtttctacaa caacaagaca      540

ctgctgtcat ttttcctgag gcacctgaag aggaccagag gcagggcaca ccagaagcca      600

gtggtcatga tgaaaatgga acaccagatg cattttcaca attactcacc tgtccatatt      660

gtgatagagg ctataaacgc tttacctctc tgaaagaaca cattaaatat cgtcatgaaa      720

agaatgaaga taactttagt tgctccctgt gcagttacac ctttgcatac agaacccaac      780

ttgaacgtca catgacatca cataaatcag gaagagatca aagacatgtg acgcagtctg      840

ggtgtaatcg taaattcaaa tgcactgagt gtggaaaagc tttcaaatac aaacatcacc      900

taaaagagca cttaagaatt cacagtggag agaagccata tgaatgccca aactgcaaga      960

aacgcttttc ccattctggc tcctatagct cacacataag cagtaagaaa tgtatcagct     1020

tgatacctgt gaatgggcga ccaagaacag gactcaagac atctcagtgt tcttcaccgt     1080

ctctttcagc atcaccaggc agtcccacac gaccacagat acggcaaaag atagagaata     1140

aaccccttca agaacaactt tctgttaacc aaattaaaac tgaacctgtg gattatgaat     1200

tcaaacccat agtggttgct tcaggaatca actgttcaac ccctttacaa aatggggttt     1260

tcactggtgg tggcccatta caggcaacca gttctcctca gggcatggtg caagctgttg     1320

ttctgccaac agttggtttg gtgtctccca taagtatcaa tttaagtgat attcagaatg     1380

tacttaaagt ggcggtagat ggtaatgtaa taaggcaagt gttggagaat aatcaagcca     1440

atcttgcatc caaagaacaa gaaacaatca atgcttcacc catacaacaa ggtggccatt     1500

ctgttatttc agccatcagt cttcctttgg ttgatcaaga tggaacaacc aaaattatca     1560

tcaactacag tcttgagcag cctagccaac ttcaagttgt tcctcaaaat ttaaaaaaag     1620

aaaatccagt cgctacaaac agttgtaaaa gtgaaaagtt accagaagat cttactgtta     1680

agtctgagaa ggacaaaagc tttgaagggg gggtgaatga tagcacttgt cttctgtgtg     1740

atgattgtcc aggagatatt aatgcacttc cagaattaaa gcactatgac ctaaagcagc     1800

ctactcagcc tcctccactc cctgcagcag aagctgagaa gcctgagtcc tctgtttcat     1860

cagctactgg agatggcaat ttgtctccta gtcagccacc tttaaagaac ctcttgtctc     1920

tcctaaaagc atattatgct ttgaatgcac aaccaagtgc agaagagctc tcaaaaattg     1980

ctgattcagt aaacctacca ctggatgtag taaaaaagtg gtttgaaaag atgcaagctg     2040

gacagatttc agtgcagtct tctgaaccat cttctcctga accaggcaaa gtaaatatcc     2100

ctgccaagaa caatgatcag cctcaatctg caaatgcaaa tgaaccccag gacagcacag     2160

taaatctaca aagtcctttg aagatgacta actccccagt tttaccagtg ggatcaacca     2220

ccaatggttc cagaagtagt acaccatccc catcacctct aaacctttcc tcatccagaa     2280

atacacaggg ttacttgtac acagctgagg gtgcacaaga agagccacaa gtagaacctc     2340

ttgatctttc actaccaaag caacagggag aattattaga aaggtcaact atcactagtg     2400

tttaccagaa cagtgtttat tctgtccagg aagaaccctt gaacttgtct tgcgcaaaaa     2460

aggagccaca aaaggacagt tgtgttacag actcagaacc agttgtaaat gtaatcccac     2520

caagtgccaa ccccataaat atcgctatac ctacagtcac tgcccagtta cccacaatcg     2580

tggccattgc tgaccagaac agtgttccat gcttaagagc gctagctgcc aataagcaaa     2640

cgattctgat tccccaggtg gcatacacct actcaactac ggtcagccct gcagtccaag     2700

aaccaccctt gaaagtgatc cagccaaatg gaaatcagga tgaaagacaa gatactagct     2760

cagaaggagt atcaaatgta gaggatcaga atgactctga ttctacaccg cccaaaaaga     2820

aaatgcggaa gacagaaaat ggaatgtatg cttgtgattt gtgtgacaag atattccaaa     2880

agagtagttc attattgaga cataaatatg aacacacagg taaaagacct catgagtgtg     2940

gaatctgtaa aaaggcattt aaacacaaac atcatttgat tgaacacatg cgattacatt     3000

ctggagaaaa gccctatcaa tgtgacaaat gtggaaagcg cttctcacac tctgggtctt     3060

attctcaaca catgaatcat cgctactcct actgtaagag agaagcggaa gaacgtgaca     3120

gcacagagca ggaagaggca gggcctgaaa tcctctcgaa tgagcacgtg ggtgccaggg     3180

cgtctccctc acagggcgac tcggacgaga gagagagttt gacaagggaa gaggatgaag     3240

acagtgaaaa agaggaagag gaggaggata aagagatgga agaattgcag gaagaaaaag     3300

aatgtgaaaa accacaaggg gatgaggaag aggaggagga ggaggaagaa gtggaagaag     3360

aagaggtaga agaggcagag aatgagggag aagaagcaaa aactgaaggt ctgatgaagg     3420

atgacagggc tgaaagtcaa gcaagcagct taggacaaaa agtaggcgag agtagtgagc     3480

aagtgtctga agaaaagaca aatgaagcct aatcgttttt ctagaaggaa aataaattct     3540

aattgataat gaatttcgtt caatattatc cttgcttttc atggaaacac agtaacctgt     3600

atgctgtgat tcctgttcac tactgtgtaa agtaaaaact aaaaaaatac aaaatacaaa     3660

acacacacac acacacacac acacacacac acacacacac aaaataaatc cgggtgtgcc     3720

tgaacctcag acctagtaat ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca     3780

tgcagcagat tagaaaacct taatgactca gagagcaaca atacaagagg ttaaaggaag     3840

ctgattaatt agatatgcat ctggcattgt tttatcttat cagtattatc actcttatgt     3900

tggtttattc ttaagctgta caattgggag aaattttata attttttatt ggtaaacata     3960

tgctaaatcc gcttcagtat tttattatgt tttttaaaat gtgagaactt ctgcactaca     4020

aaattccctt cacagagaag tataatgtag ttccaacccg tgctaactac cttttataaa     4080

ttcagtctag aaggtagtaa tttctaatat ttagatgtct tagtagagcg tattatcatt     4140

taaagtgtat tgttagcctt aagaaagcag ctgatagaag aactgaagtt tcttactcac     4200

gtggtttaaa atggagttca aaagattgcc attgagttct gattgcaggg actaacaatg     4260

ttaatctgat aaggacagca aaatcatcag aatcagtgtt tgtgattgtg tttgaatatg     4320

tggtaacata tgaaggatat gacatgaagc tttgtatctc ctttggcctt aagcaagacc     4380

tgtgtgctgt aagtgccatt tctcagtatt ttcaaggctc taacccgcct tcatccaatg     4440

tgtggcctac aataactagc atttgttgat ttgtctcttg tatcaaaatt cccaaataaa     4500

acttaaaacc actgactctg tcagagaaac tgaaacactg ggacatttca tccttcaatt     4560

cctcggtatt gattttatgt tgattgattt tcagaatttc tctacagaaa cgaaagggaa     4620

attttctaat ctgctttatc catgtacttg catttcagac atggacatgc tattgttatt     4680

tggctcataa ctgtttccaa atgttagtta ttatggaccc aatttattaa caacattagc     4740

tgatttttac ctatcagtat tattttattt cttttagttt atagatctgt gcaacatttt     4800

tgtactgtat gtcttcaaac ctggcagtat taataccctt cttactgaca tatgtacttt     4860

tagttttaga aaacttttat atttatgtgt cttattttta tatttcttta tttattacac     4920

agtgtagtgt ataatactgt agtttgtatt aatacaataa tatattttag tatgaaaatt     4980

tggaaagttg ataagattta aagtagagat gcaattggtt ctcctgcatt gagatttgat     5040

ttaacagtgt tatgttaaca tttatacttg ccttggactg tagaacagaa cttaaatggg     5100

aatgtattag ttttacaact acaatcaagt cattttacct ttacccagtt tttaatataa     5160

aacttaaatt ttgaaattca ctgtgtgact aatagcatga tgctctgcag ttttattaag     5220

aaatcagcct aaccatacaa ctctcatttc cttagtaagc caaattagga ttaacttcta     5280

taaacagtgt tgggaacaat gtttaacatt ttgtgccaat ttgttcctgt attcatgtat     5340

gtaagttaca gatctgactc ttcattttta agttccttgt tacatcatgg tcattttcta     5400

gttttttacc agactcccat ctcacaataa aatgcatcaa caagcctgaa ctgctgtcat     5460

tcttttcatc attatcagta ttttctttgg aaaactgtga aatggggtac attgtcatcc     5520

tgcatttgat tcatcttgag ctgaatttgg gtaacactaa atgttttaga cattctccac     5580

taaattatgg attttcttgt ggctaaatgt ttctggagag gtcagagttg acaaaacctc     5640

ttcacaggtt gctccttctt cctgaaatcc ttaatcctcc gcatttcatg cttcaggtca     5700

tttcagggaa gcctgggttt agatgccttt ctgactctca gctcctgcac ttctgtcatc     5760

atacctctga tactattatt tatattcctt ccccactagg aacaggaacc acatttgtca     5820

tagtcactct cacattcctc actgcctaac agggtgcctg gcataagttg ggacaacaga     5880

tatttgttga ataaaaatat aatttgcatg tttatggagc tcagctatgt tctcactttt     5940

tttgcttcta attccagaat atatgttaaa tgatctaata atttgattat tttcttataa     6000

gtcttattaa acactagtca taatagacac aataaattat gccttctttt tc             6052


<210> 108
<211> 1111
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Thr Cys Ala Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn 
1               5                   10                  15      


Ser Asp Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser 
            20                  25                  30          


Val Thr Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro 
        35                  40                  45              


Thr Asp Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn 
    50                  55                  60                  


Ala Lys Asn Cys Trp Glu Asp Asp Thr Gly Lys Glu Gly Gln Glu Ile 
65                  70                  75                  80  


Leu Gly Pro Glu Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp 
                85                  90                  95      


Asp Glu Cys Glu Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn 
            100                 105                 110         


Val Glu Glu Phe Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu 
        115                 120                 125             


Ala Pro Glu Glu Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His 
    130                 135                 140                 


Asp Glu Asn Gly Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro 
145                 150                 155                 160 


Tyr Cys Asp Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile 
                165                 170                 175     


Lys Tyr Arg His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys 
            180                 185                 190         


Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser 
        195                 200                 205             


His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn 
    210                 215                 220                 


Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His 
225                 230                 235                 240 


His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu 
                245                 250                 255     


Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser 
            260                 265                 270         


His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg 
        275                 280                 285             


Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser 
    290                 295                 300                 


Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu 
305                 310                 315                 320 


Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu 
                325                 330                 335     


Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn 
            340                 345                 350         


Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu 
        355                 360                 365             


Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro 
    370                 375                 380                 


Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln 
385                 390                 395                 400 


Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu 
                405                 410                 415     


Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn 
            420                 425                 430         


Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser 
        435                 440                 445             


Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr 
    450                 455                 460                 


Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys 
465                 470                 475                 480 


Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro 
                485                 490                 495     


Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly 
            500                 505                 510         


Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile 
        515                 520                 525             


Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln 
    530                 535                 540                 


Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val 
545                 550                 555                 560 


Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu 
                565                 570                 575     


Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln 
            580                 585                 590         


Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro 
        595                 600                 605             


Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile 
    610                 615                 620                 


Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn 
625                 630                 635                 640 


Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu 
                645                 650                 655     


Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn 
            660                 665                 670         


Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser 
        675                 680                 685             


Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln 
    690                 695                 700                 


Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu 
705                 710                 715                 720 


Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg 
                725                 730                 735     


Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu 
            740                 745                 750         


Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser 
        755                 760                 765             


Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala 
    770                 775                 780                 


Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr 
785                 790                 795                 800 


Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu 
                805                 810                 815     


Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr 
            820                 825                 830         


Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile 
        835                 840                 845             


Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly 
    850                 855                 860                 


Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys 
865                 870                 875                 880 


Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys 
                885                 890                 895     


Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu 
            900                 905                 910         


His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe 
        915                 920                 925             


Lys His Lys His His Leu Ile Glu His Met Arg Leu His Ser Gly Glu 
    930                 935                 940                 


Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly 
945                 950                 955                 960 


Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu 
                965                 970                 975     


Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly Pro Glu Ile 
            980                 985                 990         


Leu Ser Asn Glu His Val Gly Ala  Arg Ala Ser Pro Ser  Gln Gly Asp 
        995                 1000                 1005             


Ser Asp  Glu Arg Glu Ser Leu  Thr Arg Glu Glu Asp  Glu Asp Ser 
    1010                 1015                 1020             


Glu Lys  Glu Glu Glu Glu Glu  Asp Lys Glu Met Glu  Glu Leu Gln 
    1025                 1030                 1035             


Glu Glu  Lys Glu Cys Glu Lys  Pro Gln Gly Asp Glu  Glu Glu Glu 
    1040                 1045                 1050             


Glu Glu  Glu Glu Glu Val Glu  Glu Glu Glu Val Glu  Glu Ala Glu 
    1055                 1060                 1065             


Asn Glu  Gly Glu Glu Ala Lys  Thr Glu Gly Leu Met  Lys Asp Asp 
    1070                 1075                 1080             


Arg Ala  Glu Ser Gln Ala Ser  Ser Leu Gly Gln Lys  Val Gly Glu 
    1085                 1090                 1095             


Ser Ser  Glu Gln Val Ser Glu  Glu Lys Thr Asn Glu  Ala 
    1100                 1105                 1110     


<210> 109
<211> 6049
<212> DNA
<213> Homo sapiens

<400> 109
gcagctgctg taaacatgtt tacctgaaca ggaaagaatg gatttttctc cttgagatcc       60

tgtgatatga atattacact cgtaaggcat atcaacagat gacttaaggg gggaaaagcg      120

atcctgaaag atacttgaaa tcaacaggaa agagaggttc ttgatcgctg cagcaaatgg      180

caacttgtgc agttacaaat tataatactg tggtagaaac aaattcagat tcagatgatg      240

aagacaaact gcatattgtg gaagaagaaa gtgttacaga tgcagctgac tgtgaaggtg      300

taccagagga tgacctgcca acagaccaga cagtgttacc agggaggagc agtgaaagag      360

aagggaatgc taagaactgc tgggaggatg acagaaagga agggcaagaa atcctggggc      420

ctgaagctca ggcagatgaa gcaggatgta cagtaaaaga tgatgaatgc gagtcagatg      480

cagaaaatga gcaaaaccat gatcctaatg ttgaagagtt tctacaacaa caagacactg      540

ctgtcatttt tcctgaggca cctgaagagg accagaggca gggcacacca gaagccagtg      600

gtcatgatga aaatggaaca ccagatgcat tttcacaatt actcacctgt ccatattgtg      660

atagaggcta taaacgcttt acctctctga aagaacacat taaatatcgt catgaaaaga      720

atgaagataa ctttagttgc tccctgtgca gttacacctt tgcatacaga acccaacttg      780

aacgtcacat gacatcacat aaatcaggaa gagatcaaag acatgtgacg cagtctgggt      840

gtaatcgtaa attcaaatgc actgagtgtg gaaaagcttt caaatacaaa catcacctaa      900

aagagcactt aagaattcac agtggagaga agccatatga atgcccaaac tgcaagaaac      960

gcttttccca ttctggctcc tatagctcac acataagcag taagaaatgt atcagcttga     1020

tacctgtgaa tgggcgacca agaacaggac tcaagacatc tcagtgttct tcaccgtctc     1080

tttcagcatc accaggcagt cccacacgac cacagatacg gcaaaagata gagaataaac     1140

cccttcaaga acaactttct gttaaccaaa ttaaaactga acctgtggat tatgaattca     1200

aacccatagt ggttgcttca ggaatcaact gttcaacccc tttacaaaat ggggttttca     1260

ctggtggtgg cccattacag gcaaccagtt ctcctcaggg catggtgcaa gctgttgttc     1320

tgccaacagt tggtttggtg tctcccataa gtatcaattt aagtgatatt cagaatgtac     1380

ttaaagtggc ggtagatggt aatgtaataa ggcaagtgtt ggagaataat caagccaatc     1440

ttgcatccaa agaacaagaa acaatcaatg cttcacccat acaacaaggt ggccattctg     1500

ttatttcagc catcagtctt cctttggttg atcaagatgg aacaaccaaa attatcatca     1560

actacagtct tgagcagcct agccaacttc aagttgttcc tcaaaattta aaaaaagaaa     1620

atccagtcgc tacaaacagt tgtaaaagtg aaaagttacc agaagatctt actgttaagt     1680

ctgagaagga caaaagcttt gaaggggggg tgaatgatag cacttgtctt ctgtgtgatg     1740

attgtccagg agatattaat gcacttccag aattaaagca ctatgaccta aagcagccta     1800

ctcagcctcc tccactccct gcagcagaag ctgagaagcc tgagtcctct gtttcatcag     1860

ctactggaga tggcaatttg tctcctagtc agccaccttt aaagaacctc ttgtctctcc     1920

taaaagcata ttatgctttg aatgcacaac caagtgcaga agagctctca aaaattgctg     1980

attcagtaaa cctaccactg gatgtagtaa aaaagtggtt tgaaaagatg caagctggac     2040

agatttcagt gcagtcttct gaaccatctt ctcctgaacc aggcaaagta aatatccctg     2100

ccaagaacaa tgatcagcct caatctgcaa atgcaaatga accccaggac agcacagtaa     2160

atctacaaag tcctttgaag atgactaact ccccagtttt accagtggga tcaaccacca     2220

atggttccag aagtagtaca ccatccccat cacctctaaa cctttcctca tccagaaata     2280

cacagggtta cttgtacaca gctgagggtg cacaagaaga gccacaagta gaacctcttg     2340

atctttcact accaaagcaa cagggagaat tattagaaag gtcaactatc actagtgttt     2400

accagaacag tgtttattct gtccaggaag aacccttgaa cttgtcttgc gcaaaaaagg     2460

agccacaaaa ggacagttgt gttacagact cagaaccagt tgtaaatgta atcccaccaa     2520

gtgccaaccc cataaatatc gctataccta cagtcactgc ccagttaccc acaatcgtgg     2580

ccattgctga ccagaacagt gttccatgct taagagcgct agctgccaat aagcaaacga     2640

ttctgattcc ccaggtggca tacacctact caactacggt cagccctgca gtccaagaac     2700

cacccttgaa agtgatccag ccaaatggaa atcaggatga aagacaagat actagctcag     2760

aaggagtatc aaatgtagag gatcagaatg actctgattc tacaccgccc aaaaagaaaa     2820

tgcggaagac agaaaatgga atgtatgctt gtgatttgtg tgacaagata ttccaaaaga     2880

gtagttcatt attgagacat aaatatgaac acacaggtaa aagacctcat gagtgtggaa     2940

tctgtaaaaa ggcatttaaa cacaaacatc atttgattga acacatgcga ttacattctg     3000

gagaaaagcc ctatcaatgt gacaaatgtg gaaagcgctt ctcacactct gggtcttatt     3060

ctcaacacat gaatcatcgc tactcctact gtaagagaga agcggaagaa cgtgacagca     3120

cagagcagga agaggcaggg cctgaaatcc tctcgaatga gcacgtgggt gccagggcgt     3180

ctccctcaca gggcgactcg gacgagagag agagtttgac aagggaagag gatgaagaca     3240

gtgaaaaaga ggaagaggag gaggataaag agatggaaga attgcaggaa gaaaaagaat     3300

gtgaaaaacc acaaggggat gaggaagagg aggaggagga ggaagaagtg gaagaagaag     3360

aggtagaaga ggcagagaat gagggagaag aagcaaaaac tgaaggtctg atgaaggatg     3420

acagggctga aagtcaagca agcagcttag gacaaaaagt aggcgagagt agtgagcaag     3480

tgtctgaaga aaagacaaat gaagcctaat cgtttttcta gaaggaaaat aaattctaat     3540

tgataatgaa tttcgttcaa tattatcctt gcttttcatg gaaacacagt aacctgtatg     3600

ctgtgattcc tgttcactac tgtgtaaagt aaaaactaaa aaaatacaaa atacaaaaca     3660

cacacacaca cacacacaca cacacacaca cacacacaaa ataaatccgg gtgtgcctga     3720

acctcagacc tagtaatttt tcatgcagtt ttcaaagtta ggaacaagtt tgtaacatgc     3780

agcagattag aaaaccttaa tgactcagag agcaacaata caagaggtta aaggaagctg     3840

attaattaga tatgcatctg gcattgtttt atcttatcag tattatcact cttatgttgg     3900

tttattctta agctgtacaa ttgggagaaa ttttataatt ttttattggt aaacatatgc     3960

taaatccgct tcagtatttt attatgtttt ttaaaatgtg agaacttctg cactacaaaa     4020

ttcccttcac agagaagtat aatgtagttc caacccgtgc taactacctt ttataaattc     4080

agtctagaag gtagtaattt ctaatattta gatgtcttag tagagcgtat tatcatttaa     4140

agtgtattgt tagccttaag aaagcagctg atagaagaac tgaagtttct tactcacgtg     4200

gtttaaaatg gagttcaaaa gattgccatt gagttctgat tgcagggact aacaatgtta     4260

atctgataag gacagcaaaa tcatcagaat cagtgtttgt gattgtgttt gaatatgtgg     4320

taacatatga aggatatgac atgaagcttt gtatctcctt tggccttaag caagacctgt     4380

gtgctgtaag tgccatttct cagtattttc aaggctctaa cccgccttca tccaatgtgt     4440

ggcctacaat aactagcatt tgttgatttg tctcttgtat caaaattccc aaataaaact     4500

taaaaccact gactctgtca gagaaactga aacactggga catttcatcc ttcaattcct     4560

cggtattgat tttatgttga ttgattttca gaatttctct acagaaacga aagggaaatt     4620

ttctaatctg ctttatccat gtacttgcat ttcagacatg gacatgctat tgttatttgg     4680

ctcataactg tttccaaatg ttagttatta tggacccaat ttattaacaa cattagctga     4740

tttttaccta tcagtattat tttatttctt ttagtttata gatctgtgca acatttttgt     4800

actgtatgtc ttcaaacctg gcagtattaa tacccttctt actgacatat gtacttttag     4860

ttttagaaaa cttttatatt tatgtgtctt atttttatat ttctttattt attacacagt     4920

gtagtgtata atactgtagt ttgtattaat acaataatat attttagtat gaaaatttgg     4980

aaagttgata agatttaaag tagagatgca attggttctc ctgcattgag atttgattta     5040

acagtgttat gttaacattt atacttgcct tggactgtag aacagaactt aaatgggaat     5100

gtattagttt tacaactaca atcaagtcat tttaccttta cccagttttt aatataaaac     5160

ttaaattttg aaattcactg tgtgactaat agcatgatgc tctgcagttt tattaagaaa     5220

tcagcctaac catacaactc tcatttcctt agtaagccaa attaggatta acttctataa     5280

acagtgttgg gaacaatgtt taacattttg tgccaatttg ttcctgtatt catgtatgta     5340

agttacagat ctgactcttc atttttaagt tccttgttac atcatggtca ttttctagtt     5400

ttttaccaga ctcccatctc acaataaaat gcatcaacaa gcctgaactg ctgtcattct     5460

tttcatcatt atcagtattt tctttggaaa actgtgaaat ggggtacatt gtcatcctgc     5520

atttgattca tcttgagctg aatttgggta acactaaatg ttttagacat tctccactaa     5580

attatggatt ttcttgtggc taaatgtttc tggagaggtc agagttgaca aaacctcttc     5640

acaggttgct ccttcttcct gaaatcctta atcctccgca tttcatgctt caggtcattt     5700

cagggaagcc tgggtttaga tgcctttctg actctcagct cctgcacttc tgtcatcata     5760

cctctgatac tattatttat attccttccc cactaggaac aggaaccaca tttgtcatag     5820

tcactctcac attcctcact gcctaacagg gtgcctggca taagttggga caacagatat     5880

ttgttgaata aaaatataat ttgcatgttt atggagctca gctatgttct cacttttttt     5940

gcttctaatt ccagaatata tgttaaatga tctaataatt tgattatttt cttataagtc     6000

ttattaaaca ctagtcataa tagacacaat aaattatgcc ttctttttc                 6049


<210> 110
<211> 1110
<212> PRT
<213> Homo sapiens

<400> 110
Met Ala Thr Cys Ala Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn 
1               5                   10                  15      


Ser Asp Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser 
            20                  25                  30          


Val Thr Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro 
        35                  40                  45              


Thr Asp Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn 
    50                  55                  60                  


Ala Lys Asn Cys Trp Glu Asp Asp Arg Lys Glu Gly Gln Glu Ile Leu 
65                  70                  75                  80  


Gly Pro Glu Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp 
                85                  90                  95      


Glu Cys Glu Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val 
            100                 105                 110         


Glu Glu Phe Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala 
        115                 120                 125             


Pro Glu Glu Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp 
    130                 135                 140                 


Glu Asn Gly Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr 
145                 150                 155                 160 


Cys Asp Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys 
                165                 170                 175     


Tyr Arg His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser 
            180                 185                 190         


Tyr Thr Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser His 
        195                 200                 205             


Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg 
    210                 215                 220                 


Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His 
225                 230                 235                 240 


Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys 
                245                 250                 255     


Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His 
            260                 265                 270         


Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro 
        275                 280                 285             


Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala 
    290                 295                 300                 


Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn 
305                 310                 315                 320 


Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro 
                325                 330                 335     


Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys 
            340                 345                 350         


Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln 
        355                 360                 365             


Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro Thr 
    370                 375                 380                 


Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn 
385                 390                 395                 400 


Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu 
                405                 410                 415     


Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala 
            420                 425                 430         


Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu 
        435                 440                 445             


Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser 
    450                 455                 460                 


Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys 
465                 470                 475                 480 


Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu 
                485                 490                 495     


Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val 
            500                 505                 510         


Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn 
        515                 520                 525             


Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro 
    530                 535                 540                 


Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser 
545                 550                 555                 560 


Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys 
                565                 570                 575     


Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro 
            580                 585                 590         


Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu 
        595                 600                 605             


Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser 
    610                 615                 620                 


Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile 
625                 630                 635                 640 


Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro 
                645                 650                 655     


Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser 
            660                 665                 670         


Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr 
        675                 680                 685             


Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly 
    690                 695                 700                 


Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro 
705                 710                 715                 720 


Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser 
                725                 730                 735     


Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu 
            740                 745                 750         


Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys 
        755                 760                 765             


Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn 
    770                 775                 780                 


Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile 
785                 790                 795                 800 


Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala 
                805                 810                 815     


Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser 
            820                 825                 830         


Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln 
        835                 840                 845             


Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val 
    850                 855                 860                 


Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys 
865                 870                 875                 880 


Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp 
                885                 890                 895     


Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His 
            900                 905                 910         


Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys 
        915                 920                 925             


His Lys His His Leu Ile Glu His Met Arg Leu His Ser Gly Glu Lys 
    930                 935                 940                 


Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser 
945                 950                 955                 960 


Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala 
                965                 970                 975     


Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly Pro Glu Ile Leu 
            980                 985                 990         


Ser Asn Glu His Val Gly Ala Arg  Ala Ser Pro Ser Gln  Gly Asp Ser 
        995                 1000                 1005             


Asp Glu  Arg Glu Ser Leu Thr  Arg Glu Glu Asp Glu  Asp Ser Glu 
    1010                 1015                 1020             


Lys Glu  Glu Glu Glu Glu Asp  Lys Glu Met Glu Glu  Leu Gln Glu 
    1025                 1030                 1035             


Glu Lys  Glu Cys Glu Lys Pro  Gln Gly Asp Glu Glu  Glu Glu Glu 
    1040                 1045                 1050             


Glu Glu  Glu Glu Val Glu Glu  Glu Glu Val Glu Glu  Ala Glu Asn 
    1055                 1060                 1065             


Glu Gly  Glu Glu Ala Lys Thr  Glu Gly Leu Met Lys  Asp Asp Arg 
    1070                 1075                 1080             


Ala Glu  Ser Gln Ala Ser Ser  Leu Gly Gln Lys Val  Gly Glu Ser 
    1085                 1090                 1095             


Ser Glu  Gln Val Ser Glu Glu  Lys Thr Asn Glu Ala  
    1100                 1105                 1110 


<210> 111
<211> 5967
<212> DNA
<213> Homo sapiens

<400> 111
gtgtgggatt tcctgtctag aagcagatac gaagattttt aagctgtttc aagatgtttc       60

cttccaatcc ataattatat ttttaatata ttcgagccat cattaaaatc actgctttcg      120

tgattttaat tattcaaata aacacttgca ttttaaagac gtctgttgat tataaacgaa      180

aggtattttg gtattctcat tgtggagaga tgacttgtta tagcaaggag tggagcatag      240

gctattgcaa ttttaatttc ctgttttagc gtcaaatagt gtgtgttcca tattgagctg      300

ttgccgctgt tgctgatgtg gctttatgaa agttacaaat tataatactg tggtagaaac      360

aaattcagat tcagatgatg aagacaaact gcatattgtg gaagaagaaa gtgttacaga      420

tgcagctgac tgtgaaggtg taccagagga tgacctgcca acagaccaga cagtgttacc      480

agggaggagc agtgaaagag aagggaatgc taagaactgc tgggaggatg acagaacacc      540

agatgcattt tcacaattac tcacctgtcc atattgtgat agaggctata aacgctttac      600

ctctctgaaa gaacacatta aatatcgtca tgaaaagaat gaagataact ttagttgctc      660

cctgtgcagt tacacctttg catacagaac ccaacttgaa cgtcacatga catcacataa      720

atcaggaaga gatcaaagac atgtgacgca gtctgggtgt aatcgtaaat tcaaatgcac      780

tgagtgtgga aaagctttca aatacaaaca tcacctaaaa gagcacttaa gaattcacag      840

tggagagaag ccatatgaat gcccaaactg caagaaacgc ttttcccatt ctggctccta      900

tagctcacac ataagcagta agaaatgtat cagcttgata cctgtgaatg ggcgaccaag      960

aacaggactc aagacatctc agtgttcttc accgtctctt tcagcatcac caggcagtcc     1020

cacacgacca cagatacggc aaaagataga gaataaaccc cttcaagaac aactttctgt     1080

taaccaaatt aaaactgaac ctgtggatta tgaattcaaa cccatagtgg ttgcttcagg     1140

aatcaactgt tcaacccctt tacaaaatgg ggttttcact ggtggtggcc cattacaggc     1200

aaccagttct cctcagggca tggtgcaagc tgttgttctg ccaacagttg gtttggtgtc     1260

tcccataagt atcaatttaa gtgatattca gaatgtactt aaagtggcgg tagatggtaa     1320

tgtaataagg caagtgttgg agaataatca agccaatctt gcatccaaag aacaagaaac     1380

aatcaatgct tcacccatac aacaaggtgg ccattctgtt atttcagcca tcagtcttcc     1440

tttggttgat caagatggaa caaccaaaat tatcatcaac tacagtcttg agcagcctag     1500

ccaacttcaa gttgttcctc aaaatttaaa aaaagaaaat ccagtcgcta caaacagttg     1560

taaaagtgaa aagttaccag aagatcttac tgttaagtct gagaaggaca aaagctttga     1620

agggggggtg aatgatagca cttgtcttct gtgtgatgat tgtccaggag atattaatgc     1680

acttccagaa ttaaagcact atgacctaaa gcagcctact cagcctcctc cactccctgc     1740

agcagaagct gagaagcctg agtcctctgt ttcatcagct actggagatg gcaatttgtc     1800

tcctagtcag ccacctttaa agaacctctt gtctctccta aaagcatatt atgctttgaa     1860

tgcacaacca agtgcagaag agctctcaaa aattgctgat tcagtaaacc taccactgga     1920

tgtagtaaaa aagtggtttg aaaagatgca agctggacag atttcagtgc agtcttctga     1980

accatcttct cctgaaccag gcaaagtaaa tatccctgcc aagaacaatg atcagcctca     2040

atctgcaaat gcaaatgaac cccaggacag cacagtaaat ctacaaagtc ctttgaagat     2100

gactaactcc ccagttttac cagtgggatc aaccaccaat ggttccagaa gtagtacacc     2160

atccccatca cctctaaacc tttcctcatc cagaaataca cagggttact tgtacacagc     2220

tgagggtgca caagaagagc cacaagtaga acctcttgat ctttcactac caaagcaaca     2280

gggagaatta ttagaaaggt caactatcac tagtgtttac cagaacagtg tttattctgt     2340

ccaggaagaa cccttgaact tgtcttgcgc aaaaaaggag ccacaaaagg acagttgtgt     2400

tacagactca gaaccagttg taaatgtaat cccaccaagt gccaacccca taaatatcgc     2460

tatacctaca gtcactgccc agttacccac aatcgtggcc attgctgacc agaacagtgt     2520

tccatgctta agagcgctag ctgccaataa gcaaacgatt ctgattcccc aggtggcata     2580

cacctactca actacggtca gccctgcagt ccaagaacca cccttgaaag tgatccagcc     2640

aaatggaaat caggatgaaa gacaagatac tagctcagaa ggagtatcaa atgtagagga     2700

tcagaatgac tctgattcta caccgcccaa aaagaaaatg cggaagacag aaaatggaat     2760

gtatgcttgt gatttgtgtg acaagatatt ccaaaagagt agttcattat tgagacataa     2820

atatgaacac acaggtaaaa gacctcatga gtgtggaatc tgtaaaaagg catttaaaca     2880

caaacatcat ttgattgaac acatgcgatt acattctgga gaaaagccct atcaatgtga     2940

caaatgtgga aagcgcttct cacactctgg gtcttattct caacacatga atcatcgcta     3000

ctcctactgt aagagagaag cggaagaacg tgacagcaca gagcaggaag aggcagggcc     3060

tgaaatcctc tcgaatgagc acgtgggtgc cagggcgtct ccctcacagg gcgactcgga     3120

cgagagagag agtttgacaa gggaagagga tgaagacagt gaaaaagagg aagaggagga     3180

ggataaagag atggaagaat tgcaggaaga aaaagaatgt gaaaaaccac aaggggatga     3240

ggaagaggag gaggaggagg aagaagtgga agaagaagag gtagaagagg cagagaatga     3300

gggagaagaa gcaaaaactg aaggtctgat gaaggatgac agggctgaaa gtcaagcaag     3360

cagcttagga caaaaagtag gcgagagtag tgagcaagtg tctgaagaaa agacaaatga     3420

agcctaatcg tttttctaga aggaaaataa attctaattg ataatgaatt tcgttcaata     3480

ttatccttgc ttttcatgga aacacagtaa cctgtatgct gtgattcctg ttcactactg     3540

tgtaaagtaa aaactaaaaa aatacaaaat acaaaacaca cacacacaca cacacacaca     3600

cacacacaca cacacaaaat aaatccgggt gtgcctgaac ctcagaccta gtaatttttc     3660

atgcagtttt caaagttagg aacaagtttg taacatgcag cagattagaa aaccttaatg     3720

actcagagag caacaataca agaggttaaa ggaagctgat taattagata tgcatctggc     3780

attgttttat cttatcagta ttatcactct tatgttggtt tattcttaag ctgtacaatt     3840

gggagaaatt ttataatttt ttattggtaa acatatgcta aatccgcttc agtattttat     3900

tatgtttttt aaaatgtgag aacttctgca ctacaaaatt cccttcacag agaagtataa     3960

tgtagttcca acccgtgcta actacctttt ataaattcag tctagaaggt agtaatttct     4020

aatatttaga tgtcttagta gagcgtatta tcatttaaag tgtattgtta gccttaagaa     4080

agcagctgat agaagaactg aagtttctta ctcacgtggt ttaaaatgga gttcaaaaga     4140

ttgccattga gttctgattg cagggactaa caatgttaat ctgataagga cagcaaaatc     4200

atcagaatca gtgtttgtga ttgtgtttga atatgtggta acatatgaag gatatgacat     4260

gaagctttgt atctcctttg gccttaagca agacctgtgt gctgtaagtg ccatttctca     4320

gtattttcaa ggctctaacc cgccttcatc caatgtgtgg cctacaataa ctagcatttg     4380

ttgatttgtc tcttgtatca aaattcccaa ataaaactta aaaccactga ctctgtcaga     4440

gaaactgaaa cactgggaca tttcatcctt caattcctcg gtattgattt tatgttgatt     4500

gattttcaga atttctctac agaaacgaaa gggaaatttt ctaatctgct ttatccatgt     4560

acttgcattt cagacatgga catgctattg ttatttggct cataactgtt tccaaatgtt     4620

agttattatg gacccaattt attaacaaca ttagctgatt tttacctatc agtattattt     4680

tatttctttt agtttataga tctgtgcaac atttttgtac tgtatgtctt caaacctggc     4740

agtattaata cccttcttac tgacatatgt acttttagtt ttagaaaact tttatattta     4800

tgtgtcttat ttttatattt ctttatttat tacacagtgt agtgtataat actgtagttt     4860

gtattaatac aataatatat tttagtatga aaatttggaa agttgataag atttaaagta     4920

gagatgcaat tggttctcct gcattgagat ttgatttaac agtgttatgt taacatttat     4980

acttgccttg gactgtagaa cagaacttaa atgggaatgt attagtttta caactacaat     5040

caagtcattt tacctttacc cagtttttaa tataaaactt aaattttgaa attcactgtg     5100

tgactaatag catgatgctc tgcagtttta ttaagaaatc agcctaacca tacaactctc     5160

atttccttag taagccaaat taggattaac ttctataaac agtgttggga acaatgttta     5220

acattttgtg ccaatttgtt cctgtattca tgtatgtaag ttacagatct gactcttcat     5280

ttttaagttc cttgttacat catggtcatt ttctagtttt ttaccagact cccatctcac     5340

aataaaatgc atcaacaagc ctgaactgct gtcattcttt tcatcattat cagtattttc     5400

tttggaaaac tgtgaaatgg ggtacattgt catcctgcat ttgattcatc ttgagctgaa     5460

tttgggtaac actaaatgtt ttagacattc tccactaaat tatggatttt cttgtggcta     5520

aatgtttctg gagaggtcag agttgacaaa acctcttcac aggttgctcc ttcttcctga     5580

aatccttaat cctccgcatt tcatgcttca ggtcatttca gggaagcctg ggtttagatg     5640

cctttctgac tctcagctcc tgcacttctg tcatcatacc tctgatacta ttatttatat     5700

tccttcccca ctaggaacag gaaccacatt tgtcatagtc actctcacat tcctcactgc     5760

ctaacagggt gcctggcata agttgggaca acagatattt gttgaataaa aatataattt     5820

gcatgtttat ggagctcagc tatgttctca ctttttttgc ttctaattcc agaatatatg     5880

ttaaatgatc taataatttg attattttct tataagtctt attaaacact agtcataata     5940

gacacaataa attatgcctt ctttttc                                         5967


<210> 112
<211> 1033
<212> PRT
<213> Homo sapiens

<400> 112
Met Lys Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp Ser 
1               5                   10                  15      


Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr Asp 
            20                  25                  30          


Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp Gln 
        35                  40                  45              


Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys Asn 
    50                  55                  60                  


Cys Trp Glu Asp Asp Arg Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr 
65                  70                  75                  80  


Cys Pro Tyr Cys Asp Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu 
                85                  90                  95      


His Ile Lys Tyr Arg His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser 
            100                 105                 110         


Leu Cys Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met 
        115                 120                 125             


Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly 
    130                 135                 140                 


Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr 
145                 150                 155                 160 


Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys Pro 
                165                 170                 175     


Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr 
            180                 185                 190         


Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn 
        195                 200                 205             


Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser 
    210                 215                 220                 


Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys 
225                 230                 235                 240 


Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys 
                245                 250                 255     


Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly 
            260                 265                 270         


Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly 
        275                 280                 285             


Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val Val 
    290                 295                 300                 


Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp 
305                 310                 315                 320 


Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln 
                325                 330                 335     


Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr 
            340                 345                 350         


Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala 
        355                 360                 365             


Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile 
    370                 375                 380                 


Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn 
385                 390                 395                 400 


Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys 
                405                 410                 415     


Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu 
            420                 425                 430         


Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly 
        435                 440                 445             


Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro 
    450                 455                 460                 


Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser 
465                 470                 475                 480 


Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro 
                485                 490                 495     


Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn 
            500                 505                 510         


Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn 
        515                 520                 525             


Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly 
    530                 535                 540                 


Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys 
545                 550                 555                 560 


Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala 
                565                 570                 575     


Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met 
            580                 585                 590         


Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg 
        595                 600                 605             


Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn 
    610                 615                 620                 


Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln 
625                 630                 635                 640 


Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu 
                645                 650                 655     


Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val 
            660                 665                 670         


Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys 
        675                 680                 685             


Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro 
    690                 695                 700                 


Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu 
705                 710                 715                 720 


Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg 
                725                 730                 735     


Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr 
            740                 745                 750         


Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys 
        755                 760                 765             


Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser 
    770                 775                 780                 


Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro 
785                 790                 795                 800 


Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp 
                805                 810                 815     


Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys 
            820                 825                 830         


Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys 
        835                 840                 845             


Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His Ser 
    850                 855                 860                 


Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His 
865                 870                 875                 880 


Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys 
                885                 890                 895     


Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly Pro 
            900                 905                 910         


Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser Gln 
        915                 920                 925             


Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu Asp 
    930                 935                 940                 


Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu Gln 
945                 950                 955                 960 


Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu Glu 
                965                 970                 975     


Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn Glu 
            980                 985                 990         


Gly Glu Glu Ala Lys Thr Glu Gly  Leu Met Lys Asp Asp  Arg Ala Glu 
        995                 1000                 1005             


Ser Gln  Ala Ser Ser Leu Gly  Gln Lys Val Gly Glu  Ser Ser Glu 
    1010                 1015                 1020             


Gln Val  Ser Glu Glu Lys Thr  Asn Glu Ala 
    1025                 1030             


<210> 113
<211> 5934
<212> DNA
<213> Homo sapiens

<400> 113
agacacaagc gagaggatca tggcggatgg ccccaggtgt aagcgcagaa agcaggcgaa       60

cccgcggcgc aataacgtta caaattataa tactgtggta gaaacaaatt cagattcaga      120

tgatgaagac aaactgcata ttgtggaaga agaaagtgtt acagatgcag ctgactgtga      180

aggtgtacca gaggatgacc tgccaacaga ccagacagtg ttaccaggga ggagcagtga      240

aagagaaggg aatgctaaga actgctggga ggatgacaga aaggaagggc aagaaatcct      300

ggggcctgaa gctcaggcag atgaagcagg atgtacagta aaagatgatg aatgcgagtc      360

agatgcagaa aatgagcaaa accatgatcc taatgttgaa gagtttctac aacaacaaga      420

cactgctgtc atttttcctg aggcacctga agaggaccag aggcagggca caccagaagc      480

cagtggtcat gatgaaaatg gaacaccaga tgcattttca caattactca cctgtccata      540

ttgtgataga ggctataaac gctttacctc tctgaaagaa cacattaaat atcgtcatga      600

aaagaatgaa gataacttta gttgctccct gtgcagttac acctttgcat acagaaccca      660

acttgaacgt cacatgacat cacataaatc aggaagagat caaagacatg tgacgcagtc      720

tgggtgtaat cgtaaattca aatgcactga gtgtggaaaa gctttcaaat acaaacatca      780

cctaaaagag cacttaagaa ttcacagtgg agagaagcca tatgaatgcc caaactgcaa      840

gaaacgcttt tcccattctg gctcctatag ctcacacata agcagtaaga aatgtatcag      900

cttgatacct gtgaatgggc gaccaagaac aggactcaag acatctcagt gttcttcacc      960

gtctctttca gcatcaccag gcagtcccac acgaccacag atacggcaaa agatagagaa     1020

taaacccctt caagaacaac tttctgttaa ccaaattaaa actgaacctg tggattatga     1080

attcaaaccc atagtggttg cttcaggaat caactgttca acccctttac aaaatggggt     1140

tttcactggt ggtggcccat tacaggcaac cagttctcct cagggcatgg tgcaagctgt     1200

tgttctgcca acagttggtt tggtgtctcc cataagtatc aatttaagtg atattcagaa     1260

tgtacttaaa gtggcggtag atggtaatgt aataaggcaa gtgttggaga ataatcaagc     1320

caatcttgca tccaaagaac aagaaacaat caatgcttca cccatacaac aaggtggcca     1380

ttctgttatt tcagccatca gtcttccttt ggttgatcaa gatggaacaa ccaaaattat     1440

catcaactac agtcttgagc agcctagcca acttcaagtt gttcctcaaa atttaaaaaa     1500

agaaaatcca gtcgctacaa acagttgtaa aagtgaaaag ttaccagaag atcttactgt     1560

taagtctgag aaggacaaaa gctttgaagg gggggtgaat gatagcactt gtcttctgtg     1620

tgatgattgt ccaggagata ttaatgcact tccagaatta aagcactatg acctaaagca     1680

gcctactcag cctcctccac tccctgcagc agaagctgag aagcctgagt cctctgtttc     1740

atcagctact ggagatggca atttgtctcc tagtcagcca cctttaaaga acctcttgtc     1800

tctcctaaaa gcatattatg ctttgaatgc acaaccaagt gcagaagagc tctcaaaaat     1860

tgctgattca gtaaacctac cactggatgt agtaaaaaag tggtttgaaa agatgcaagc     1920

tggacagatt tcagtgcagt cttctgaacc atcttctcct gaaccaggca aagtaaatat     1980

ccctgccaag aacaatgatc agcctcaatc tgcaaatgca aatgaacccc aggacagcac     2040

agtaaatcta caaagtcctt tgaagatgac taactcccca gttttaccag tgggatcaac     2100

caccaatggt tccagaagta gtacaccatc cccatcacct ctaaaccttt cctcatccag     2160

aaatacacag ggttacttgt acacagctga gggtgcacaa gaagagccac aagtagaacc     2220

tcttgatctt tcactaccaa agcaacaggg agaattatta gaaaggtcaa ctatcactag     2280

tgtttaccag aacagtgttt attctgtcca ggaagaaccc ttgaacttgt cttgcgcaaa     2340

aaaggagcca caaaaggaca gttgtgttac agactcagaa ccagttgtaa atgtaatccc     2400

accaagtgcc aaccccataa atatcgctat acctacagtc actgcccagt tacccacaat     2460

cgtggccatt gctgaccaga acagtgttcc atgcttaaga gcgctagctg ccaataagca     2520

aacgattctg attccccagg tggcatacac ctactcaact acggtcagcc ctgcagtcca     2580

agaaccaccc ttgaaagtga tccagccaaa tggaaatcag gatgaaagac aagatactag     2640

ctcagaagga gtatcaaatg tagaggatca gaatgactct gattctacac cgcccaaaaa     2700

gaaaatgcgg aagacagaaa atggaatgta tgcttgtgat ttgtgtgaca agatattcca     2760

aaagagtagt tcattattga gacataaata tgaacacaca ggtaaaagac ctcatgagtg     2820

tggaatctgt aaaaaggcat ttaaacacaa acatcatttg attgaacaca tgcgattaca     2880

ttctggagaa aagccctatc aatgtgacaa atgtggaaag cgcttctcac actctgggtc     2940

ttattctcaa cacatgaatc atcgctactc ctactgtaag agagaagcgg aagaacgtga     3000

cagcacagag caggaagagg cagggcctga aatcctctcg aatgagcacg tgggtgccag     3060

ggcgtctccc tcacagggcg actcggacga gagagagagt ttgacaaggg aagaggatga     3120

agacagtgaa aaagaggaag aggaggagga taaagagatg gaagaattgc aggaagaaaa     3180

agaatgtgaa aaaccacaag gggatgagga agaggaggag gaggaggaag aagtggaaga     3240

agaagaggta gaagaggcag agaatgaggg agaagaagca aaaactgaag gtctgatgaa     3300

ggatgacagg gctgaaagtc aagcaagcag cttaggacaa aaagtaggcg agagtagtga     3360

gcaagtgtct gaagaaaaga caaatgaagc ctaatcgttt ttctagaagg aaaataaatt     3420

ctaattgata atgaatttcg ttcaatatta tccttgcttt tcatggaaac acagtaacct     3480

gtatgctgtg attcctgttc actactgtgt aaagtaaaaa ctaaaaaaat acaaaataca     3540

aaacacacac acacacacac acacacacac acacacacac acaaaataaa tccgggtgtg     3600

cctgaacctc agacctagta atttttcatg cagttttcaa agttaggaac aagtttgtaa     3660

catgcagcag attagaaaac cttaatgact cagagagcaa caatacaaga ggttaaagga     3720

agctgattaa ttagatatgc atctggcatt gttttatctt atcagtatta tcactcttat     3780

gttggtttat tcttaagctg tacaattggg agaaatttta taatttttta ttggtaaaca     3840

tatgctaaat ccgcttcagt attttattat gttttttaaa atgtgagaac ttctgcacta     3900

caaaattccc ttcacagaga agtataatgt agttccaacc cgtgctaact accttttata     3960

aattcagtct agaaggtagt aatttctaat atttagatgt cttagtagag cgtattatca     4020

tttaaagtgt attgttagcc ttaagaaagc agctgataga agaactgaag tttcttactc     4080

acgtggttta aaatggagtt caaaagattg ccattgagtt ctgattgcag ggactaacaa     4140

tgttaatctg ataaggacag caaaatcatc agaatcagtg tttgtgattg tgtttgaata     4200

tgtggtaaca tatgaaggat atgacatgaa gctttgtatc tcctttggcc ttaagcaaga     4260

cctgtgtgct gtaagtgcca tttctcagta ttttcaaggc tctaacccgc cttcatccaa     4320

tgtgtggcct acaataacta gcatttgttg atttgtctct tgtatcaaaa ttcccaaata     4380

aaacttaaaa ccactgactc tgtcagagaa actgaaacac tgggacattt catccttcaa     4440

ttcctcggta ttgattttat gttgattgat tttcagaatt tctctacaga aacgaaaggg     4500

aaattttcta atctgcttta tccatgtact tgcatttcag acatggacat gctattgtta     4560

tttggctcat aactgtttcc aaatgttagt tattatggac ccaatttatt aacaacatta     4620

gctgattttt acctatcagt attattttat ttcttttagt ttatagatct gtgcaacatt     4680

tttgtactgt atgtcttcaa acctggcagt attaataccc ttcttactga catatgtact     4740

tttagtttta gaaaactttt atatttatgt gtcttatttt tatatttctt tatttattac     4800

acagtgtagt gtataatact gtagtttgta ttaatacaat aatatatttt agtatgaaaa     4860

tttggaaagt tgataagatt taaagtagag atgcaattgg ttctcctgca ttgagatttg     4920

atttaacagt gttatgttaa catttatact tgccttggac tgtagaacag aacttaaatg     4980

ggaatgtatt agttttacaa ctacaatcaa gtcattttac ctttacccag tttttaatat     5040

aaaacttaaa ttttgaaatt cactgtgtga ctaatagcat gatgctctgc agttttatta     5100

agaaatcagc ctaaccatac aactctcatt tccttagtaa gccaaattag gattaacttc     5160

tataaacagt gttgggaaca atgtttaaca ttttgtgcca atttgttcct gtattcatgt     5220

atgtaagtta cagatctgac tcttcatttt taagttcctt gttacatcat ggtcattttc     5280

tagtttttta ccagactccc atctcacaat aaaatgcatc aacaagcctg aactgctgtc     5340

attcttttca tcattatcag tattttcttt ggaaaactgt gaaatggggt acattgtcat     5400

cctgcatttg attcatcttg agctgaattt gggtaacact aaatgtttta gacattctcc     5460

actaaattat ggattttctt gtggctaaat gtttctggag aggtcagagt tgacaaaacc     5520

tcttcacagg ttgctccttc ttcctgaaat ccttaatcct ccgcatttca tgcttcaggt     5580

catttcaggg aagcctgggt ttagatgcct ttctgactct cagctcctgc acttctgtca     5640

tcatacctct gatactatta tttatattcc ttccccacta ggaacaggaa ccacatttgt     5700

catagtcact ctcacattcc tcactgccta acagggtgcc tggcataagt tgggacaaca     5760

gatatttgtt gaataaaaat ataatttgca tgtttatgga gctcagctat gttctcactt     5820

tttttgcttc taattccaga atatatgtta aatgatctaa taatttgatt attttcttat     5880

aagtcttatt aaacactagt cataatagac acaataaatt atgccttctt tttc           5934


<210> 114
<211> 1124
<212> PRT
<213> Homo sapiens

<400> 114
Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys Gln Ala Asn Pro Arg 
1               5                   10                  15      


Arg Asn Asn Val Thr Asn Tyr Asn Thr Val Val Glu Thr Asn Ser Asp 
            20                  25                  30          


Ser Asp Asp Glu Asp Lys Leu His Ile Val Glu Glu Glu Ser Val Thr 
        35                  40                  45              


Asp Ala Ala Asp Cys Glu Gly Val Pro Glu Asp Asp Leu Pro Thr Asp 
    50                  55                  60                  


Gln Thr Val Leu Pro Gly Arg Ser Ser Glu Arg Glu Gly Asn Ala Lys 
65                  70                  75                  80  


Asn Cys Trp Glu Asp Asp Arg Lys Glu Gly Gln Glu Ile Leu Gly Pro 
                85                  90                  95      


Glu Ala Gln Ala Asp Glu Ala Gly Cys Thr Val Lys Asp Asp Glu Cys 
            100                 105                 110         


Glu Ser Asp Ala Glu Asn Glu Gln Asn His Asp Pro Asn Val Glu Glu 
        115                 120                 125             


Phe Leu Gln Gln Gln Asp Thr Ala Val Ile Phe Pro Glu Ala Pro Glu 
    130                 135                 140                 


Glu Asp Gln Arg Gln Gly Thr Pro Glu Ala Ser Gly His Asp Glu Asn 
145                 150                 155                 160 


Gly Thr Pro Asp Ala Phe Ser Gln Leu Leu Thr Cys Pro Tyr Cys Asp 
                165                 170                 175     


Arg Gly Tyr Lys Arg Phe Thr Ser Leu Lys Glu His Ile Lys Tyr Arg 
            180                 185                 190         


His Glu Lys Asn Glu Asp Asn Phe Ser Cys Ser Leu Cys Ser Tyr Thr 
        195                 200                 205             


Phe Ala Tyr Arg Thr Gln Leu Glu Arg His Met Thr Ser His Lys Ser 
    210                 215                 220                 


Gly Arg Asp Gln Arg His Val Thr Gln Ser Gly Cys Asn Arg Lys Phe 
225                 230                 235                 240 


Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys Tyr Lys His His Leu Lys 
                245                 250                 255     


Glu His Leu Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn 
            260                 265                 270         


Cys Lys Lys Arg Phe Ser His Ser Gly Ser Tyr Ser Ser His Ile Ser 
        275                 280                 285             


Ser Lys Lys Cys Ile Ser Leu Ile Pro Val Asn Gly Arg Pro Arg Thr 
    290                 295                 300                 


Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro Ser Leu Ser Ala Ser Pro 
305                 310                 315                 320 


Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln Lys Ile Glu Asn Lys Pro 
                325                 330                 335     


Leu Gln Glu Gln Leu Ser Val Asn Gln Ile Lys Thr Glu Pro Val Asp 
            340                 345                 350         


Tyr Glu Phe Lys Pro Ile Val Val Ala Ser Gly Ile Asn Cys Ser Thr 
        355                 360                 365             


Pro Leu Gln Asn Gly Val Phe Thr Gly Gly Gly Pro Leu Gln Ala Thr 
    370                 375                 380                 


Ser Ser Pro Gln Gly Met Val Gln Ala Val Val Leu Pro Thr Val Gly 
385                 390                 395                 400 


Leu Val Ser Pro Ile Ser Ile Asn Leu Ser Asp Ile Gln Asn Val Leu 
                405                 410                 415     


Lys Val Ala Val Asp Gly Asn Val Ile Arg Gln Val Leu Glu Asn Asn 
            420                 425                 430         


Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu Thr Ile Asn Ala Ser Pro 
        435                 440                 445             


Ile Gln Gln Gly Gly His Ser Val Ile Ser Ala Ile Ser Leu Pro Leu 
    450                 455                 460                 


Val Asp Gln Asp Gly Thr Thr Lys Ile Ile Ile Asn Tyr Ser Leu Glu 
465                 470                 475                 480 


Gln Pro Ser Gln Leu Gln Val Val Pro Gln Asn Leu Lys Lys Glu Asn 
                485                 490                 495     


Pro Val Ala Thr Asn Ser Cys Lys Ser Glu Lys Leu Pro Glu Asp Leu 
            500                 505                 510         


Thr Val Lys Ser Glu Lys Asp Lys Ser Phe Glu Gly Gly Val Asn Asp 
        515                 520                 525             


Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro Gly Asp Ile Asn Ala Leu 
    530                 535                 540                 


Pro Glu Leu Lys His Tyr Asp Leu Lys Gln Pro Thr Gln Pro Pro Pro 
545                 550                 555                 560 


Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu Ser Ser Val Ser Ser Ala 
                565                 570                 575     


Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln Pro Pro Leu Lys Asn Leu 
            580                 585                 590         


Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu Asn Ala Gln Pro Ser Ala 
        595                 600                 605             


Glu Glu Leu Ser Lys Ile Ala Asp Ser Val Asn Leu Pro Leu Asp Val 
    610                 615                 620                 


Val Lys Lys Trp Phe Glu Lys Met Gln Ala Gly Gln Ile Ser Val Gln 
625                 630                 635                 640 


Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly Lys Val Asn Ile Pro Ala 
                645                 650                 655     


Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn Ala Asn Glu Pro Gln Asp 
            660                 665                 670         


Ser Thr Val Asn Leu Gln Ser Pro Leu Lys Met Thr Asn Ser Pro Val 
        675                 680                 685             


Leu Pro Val Gly Ser Thr Thr Asn Gly Ser Arg Ser Ser Thr Pro Ser 
    690                 695                 700                 


Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg Asn Thr Gln Gly Tyr Leu 
705                 710                 715                 720 


Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro Gln Val Glu Pro Leu Asp 
                725                 730                 735     


Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu Leu Glu Arg Ser Thr Ile 
            740                 745                 750         


Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser Val Gln Glu Glu Pro Leu 
        755                 760                 765             


Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln Lys Asp Ser Cys Val Thr 
    770                 775                 780                 


Asp Ser Glu Pro Val Val Asn Val Ile Pro Pro Ser Ala Asn Pro Ile 
785                 790                 795                 800 


Asn Ile Ala Ile Pro Thr Val Thr Ala Gln Leu Pro Thr Ile Val Ala 
                805                 810                 815     


Ile Ala Asp Gln Asn Ser Val Pro Cys Leu Arg Ala Leu Ala Ala Asn 
            820                 825                 830         


Lys Gln Thr Ile Leu Ile Pro Gln Val Ala Tyr Thr Tyr Ser Thr Thr 
        835                 840                 845             


Val Ser Pro Ala Val Gln Glu Pro Pro Leu Lys Val Ile Gln Pro Asn 
    850                 855                 860                 


Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser Ser Glu Gly Val Ser Asn 
865                 870                 875                 880 


Val Glu Asp Gln Asn Asp Ser Asp Ser Thr Pro Pro Lys Lys Lys Met 
                885                 890                 895     


Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys Asp Leu Cys Asp Lys Ile 
            900                 905                 910         


Phe Gln Lys Ser Ser Ser Leu Leu Arg His Lys Tyr Glu His Thr Gly 
        915                 920                 925             


Lys Arg Pro His Glu Cys Gly Ile Cys Lys Lys Ala Phe Lys His Lys 
    930                 935                 940                 


His His Leu Ile Glu His Met Arg Leu His Ser Gly Glu Lys Pro Tyr 
945                 950                 955                 960 


Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser 
                965                 970                 975     


Gln His Met Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Ala Glu Glu 
            980                 985                 990         


Arg Asp Ser Thr Glu Gln Glu Glu  Ala Gly Pro Glu Ile  Leu Ser Asn 
        995                 1000                 1005             


Glu His  Val Gly Ala Arg Ala  Ser Pro Ser Gln Gly  Asp Ser Asp 
    1010                 1015                 1020             


Glu Arg  Glu Ser Leu Thr Arg  Glu Glu Asp Glu Asp  Ser Glu Lys 
    1025                 1030                 1035             


Glu Glu  Glu Glu Glu Asp Lys  Glu Met Glu Glu Leu  Gln Glu Glu 
    1040                 1045                 1050             


Lys Glu  Cys Glu Lys Pro Gln  Gly Asp Glu Glu Glu  Glu Glu Glu 
    1055                 1060                 1065             


Glu Glu  Glu Val Glu Glu Glu  Glu Val Glu Glu Ala  Glu Asn Glu 
    1070                 1075                 1080             


Gly Glu  Glu Ala Lys Thr Glu  Gly Leu Met Lys Asp  Asp Arg Ala 
    1085                 1090                 1095             


Glu Ser  Gln Ala Ser Ser Leu  Gly Gln Lys Val Gly  Glu Ser Ser 
    1100                 1105                 1110             


Glu Gln  Val Ser Glu Glu Lys  Thr Asn Glu Ala 
    1115                 1120                 


<210> 115
<211> 5814
<212> DNA
<213> Homo sapiens

<400> 115
gaggtgactc gagcatttag acacaagcga gaggatcatg gcggatggcc ccaggtgtaa       60

gcgcagaaag caggcgaacc cgcggcgcaa taacgttttc agtttaaatt ctcaactggc      120

aattggccga aaactcccat ctgaagacat gatcatccaa atgtcatttt gtgatttggc      180

tactgtctgc ttgacatagg aaagcactat caagaaagac taatggagtg actatcaaaa      240

ggaagtcaat gatttcttaa gaatttacaa caaaaccctg tcaaagcagc attcttacgt      300

gagaatttca cttacgggag agttcttaca ggatttcaag aaggaaagcc ctgaagaggg      360

acactgattt cctcaactga atttaaaatt gttacatgca gacattttta aaggacaacc      420

ttaaacttcc accacaagag gaatataaag aggtccctcc tgcaccaaga aagatctgca      480

gatctttttc agtgttcttg gaggtgtggg gtgtgagaac ttgatcagtt tgtgtcagcc      540

accttgttct ctaaagttac aaattataat actgtggtag aaacaaattc agattcagat      600

gatgaagaca aactgcatat tgtggaagaa gaaagtgtta cagatgcagc tgactgtgaa      660

ggtgtaccag aggatgacct gccaacagac cagacagtgt taccagggag gagcagtgaa      720

agagaaggga atgctaagaa ctgctgggag gatgacacag gaaaggaagg gcaagaaatc      780

ctggggcctg aagctcaggc agatgaagca ggatgtacag taaaagatga tgaatgcgag      840

tcagatgcag aaaatgagca aaaccatgat cctaatgttg aagagtttct acaacaacaa      900

gacactgctg tcatttttcc tgaggcacct gaagaggacc agaggcaggg cacaccagaa      960

gccagtggtc atgatgaaaa tggaacacca gatgcatttt cacaattact cacctgtcca     1020

tattgtgata gaggctataa acgctttacc tctctgaaag aacacattaa atatcgtcat     1080

gaaaagaatg aagataactt tagttgctcc ctgtgcagtt acacctttgc atacagaacc     1140

caacttgaac gtcacatgac atcacataaa tcaggaagag atcaaagaca tgtgacgcag     1200

tctgggtgta atcgtaaatt caaatgcact gagtgtggaa aagctttcaa atacaaacat     1260

cacctaaaag agcacttaag aattcacagt ggagagaagc catatgaatg cccaaactgc     1320

aagaaacgct tttcccattc tggctcctat agctcacaca taagcagtaa gaaatgtatc     1380

agcttgatac ctgtgaatgg gcgaccaaga acaggactca agacatctca gtgttcttca     1440

ccgtctcttt cagcatcacc aggcagtccc acacgaccac agatacggca aaagatagag     1500

aataaacccc ttcaagaaca actttctgtt aaccaaatta aaactgaacc tgtggattat     1560

gaattcaaac ccatagtggt tgcttcagga atcaactgtt caaccccttt acaaaatggg     1620

gttttcactg gtggtggccc attacaggca accagttctc ctcagggcat ggtgcaagct     1680

gttgttctgc caacagttgg tttggtgtct cccataagta tcaatttaag tgatattcag     1740

aatgtactta aagtggcggt agatggtaat gtaataaggc aagtgttgga gaataatcaa     1800

gccaatcttg catccaaaga acaagaaaca atcaatgctt cacccataca acaaggtggc     1860

cattctgtta tttcagccat cagtcttcct ttggttgatc aagatggaac aaccaaaatt     1920

atcatcaact acagtcttga gcagcctagc caacttcaag ttgttcctca aaatttaaaa     1980

aaagaaaatc cagtcgctac aaacagttgt aaaagtgaaa agttaccaga agatcttact     2040

gttaagtctg agaaggacaa aagctttgaa gggggggtga atgatagcac ttgtcttctg     2100

tgtgatgatt gtccaggaga tattaatgca cttccagaat taaagcacta tgacctaaag     2160

cagcctactc agcctcctcc actccctgca gcagaagctg agaagcctga gtcctctgtt     2220

tcatcagcta ctggagatgg caatttgtct cctagtcagc cacctttaaa gaacctcttg     2280

tctctcctaa aagcatatta tgctttgaat gcacaaccaa gtgcagaaga gctctcaaaa     2340

attgctgatt cagtaaacct accactggat gtagtaaaaa agtggtttga aaagatgcaa     2400

gctggacaga tttcagtgca gtcttctgaa ccatcttctc ctgaaccagg caaagtaaat     2460

atccctgcca agaacaatga tcagcctcaa tctgcaaatg caaatgaacc ccaggacagc     2520

acagtaaatc tacaaagtcc tttgaagatg actaactccc cagttttacc agtgggatca     2580

accaccaatg gttccagaag tagtacacca tccccatcac ctctaaacct ttcctcatcc     2640

agaaatacac agggttactt gtacacagct gagggtgcac aagaagagcc acaagtagaa     2700

cctcttgatc tttcactacc aaagcaacag ggagaattat tagaaaggtc aactatcact     2760

agtgtttacc agaacagtgt ttattctgtc caggaagaac ccttgaactt gtcttgcgca     2820

aaaaaggagc cacaaaagga cagttgtgtt acagactcag aaccagttgt aaatgtaatc     2880

ccaccaagtg ccaaccccat aaatatcgct atacctacag tcactgccca gttacccaca     2940

atcgtggcca ttgctgacca gaacagtgtt ccatgcttaa gagcgctagc tgccaataag     3000

caaacgattc tgattcccca ggtggcatac acctactcaa ctacggtcag ccctgcagtc     3060

caagaaccac ccttgaaagt gatccagcca aatggaaatc aggatgaaag acaagatact     3120

agctcagaag gagtatcaaa tgtagaggat cagaatgact ctgattctac accgcccaaa     3180

aagaaaatgc ggaagacaga aaatggaatg tatgcttgtg atttgtgtga caagatattc     3240

caaaagagta gttcattatt gagacataaa tatgaacaca caggtaaaag acctcatgag     3300

tgtggaatct gtaaaaaggc atttaaacac aaacatcatt tgattgaaca catgcgatta     3360

cattctggag aaaagcccta tcaatgtgac aaatgtggaa agcgcttctc acactctggg     3420

tcttattctc aacacatgaa tcatcgctac tcctactgta agagagaagc ggaagaacgt     3480

gacagcacag agcaggaaga ggcagggcct gaaatcctct cgaatgagca cgtgggtgcc     3540

agggcgtctc cctcacaggg cgactcggac gagagagaga gtttgacaag ggaagaggat     3600

gaagacagtg aaaaagagga agaggaggag gataaagaga tggaagaatt gcaggaagaa     3660

aaagaatgtg aaaaaccaca aggggatgag gaagaggagg aggaggagga agaagtggaa     3720

gaagaagagg tagaagaggc agagaatgag ggagaagaag caaaaactga aggtctgatg     3780

aaggatgaca gggctgaaag tcaagcaagc agcttaggac aaaaagtagg cgagagtagt     3840

gagcaagtgt ctgaagaaaa gacaaatgaa gcctaatcgt ttttctagaa ggaaaataaa     3900

ttctaattga taatgaattt cgttcaatat tatccttgct tttcatggaa acacagtaac     3960

ctgtatgctg tgattcctgt tcactactgt gtaaagtaaa aactaaaaaa atacaaaata     4020

caaaacacac acacacacac acacacacac acacacacac acacaaaata aatccgggtg     4080

tgcctgaacc tcagacctag taatttttca tgcagttttc aaagttagga acaagtttgt     4140

aacatgcagc agattagaaa accttaatga ctcagagagc aacaatacaa gaggttaaag     4200

gaagctgatt aattagatat gcatctggca ttgttttatc ttatcagtat tatcactctt     4260

atgttggttt attcttaagc tgtacaattg ggagaaattt tataattttt tattggtaaa     4320

catatgctaa atccgcttca gtattttatt atgtttttta aaatgtgaga acttctgcac     4380

tacaaaattc ccttcacaga gaagtataat gtagttccaa cccgtgctaa ctacctttta     4440

taaattcagt ctagaaggta gtaatttcta atatttagat gtcttagtag agcgtattat     4500

catttaaagt gtattgttag ccttaagaaa gcagctgata gaagaactga agtttcttac     4560

tcacgtggtt taaaatggag ttcaaaagat tgccattgag ttctgattgc agggactaac     4620

aatgttaatc tgataaggac agcaaaatca tcagaatcag tgtttgtgat tgtgtttgaa     4680

tatgtggtaa catatgaagg atatgacatg aagctttgta tctcctttgg ccttaagcaa     4740

gacctgtgtg ctgtaagtgc catttctcag tattttcaag gctctaaccc gccttcatcc     4800

aatgtgtggc ctacaataac tagcatttgt tgatttgtct cttgtatcaa aattcccaaa     4860

taaaacttaa aaccactgac tctgtcagag aaactgaaac actgggacat ttcatccttc     4920

aattcctcgg tattgatttt atgttgattg attttcagaa tttctctaca gaaacgaaag     4980

ggaaattttc taatctgctt tatccatgta cttgcatttc agacatggac atgctattgt     5040

tatttggctc ataactgttt ccaaatgtta gttattatgg acccaattta ttaacaacat     5100

tagctgattt ttacctatca gtattatttt atttctttta gtttatagat ctgtgcaaca     5160

tttttgtact gtatgtcttc aaacctggca gtattaatac ccttcttact gacatatgta     5220

cttttagttt tagaaaactt ttatatttat gtgtcttatt tttatatttc tttatttatt     5280

acacagtgta gtgtataata ctgtagtttg tattaataca ataatatatt ttagtatgaa     5340

aatttggaaa gttgataaga tttaaagtag agatgcaatt ggttctcctg cattgagatt     5400

tgatttaaca gtgttatgtt aacatttata cttgccttgg actgtagaac agaacttaaa     5460

tgggaatgta ttagttttac aactacaatc aagtcatttt acctttaccc agtttttaat     5520

ataaaactta aattttgaaa ttcactgtgt gactaatagc atgatgctct gcagttttat     5580

taagaaatca gcctaaccat acaactctca tttccttagt aagccaaatt aggattaact     5640

tctataaaca gtgttgggaa caatgtttaa cattttgtgc caatttgttc ctgtattcat     5700

gtatgtaagt tacagatctg actcttcatt tttaagttcc ttgttacatc atggtcattt     5760

tctagttttt taccagactc ccatctcaca ataaaatgca tcaacaagcc tgaa           5814


<210> 116
<211> 906
<212> PRT
<213> Homo sapiens

<400> 116
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 117
<211> 5716
<212> DNA
<213> Homo sapiens

<400> 117
tttagacaca agcgagagga tcatggcgga tggccccagg tgtaagcgca gaaagcaggc       60

gaacccgcgg cgcaataacg ttttcagttt aaattctcaa ctggcaattg gccgaaaact      120

cccatctgaa gacatgatca tccaaatgtc attttgtgat ttggctactg tctgcttgac      180

ataggaaagc actatcaaga aagactaatg gagtgactat caaaaggaag tcaatggaca      240

accttaaact tccaccacaa gaggaatata aagaggtccc tcctgcacca agaaagatct      300

gcagatcttt ttcagtgttc ttggaggtgt ggggtgtgag aacttgatca gtttgtgtca      360

gccaccttgt tctctaaagg gaaagcccct caaaccattt tgtattctgt attacacttc      420

agaaagtgtg gaagcaaagg tcatctaatc tttaaaagtt acaaattata atactgtggt      480

agaaacaaat tcagattcag atgatgaaga caaactgcat attgtggaag aagaaagtgt      540

tacagatgca gctgactgtg aaggtgtacc agaggatgac ctgccaacag accagacagt      600

gttaccaggg aggagcagtg aaagagaagg gaatgctaag aactgctggg aggatgacac      660

aggaaaggaa gggcaagaaa tcctggggcc tgaagctcag gcagatgaag caggatgtac      720

agtaaaagat gatgaatgcg agtcagatgc agaaaatgag caaaaccatg atcctaatgt      780

tgaagagttt ctacaacaac aagacactgc tgtcattttt cctgaggcac ctgaagagga      840

ccagaggcag ggcacaccag aagccagtgg tcatgatgaa aatggaacac cagatgcatt      900

ttcacaatta ctcacctgtc catattgtga tagaggctat aaacgcttta cctctctgaa      960

agaacacatt aaatatcgtc atgaaaagaa tgaagataac tttagttgct ccctgtgcag     1020

ttacaccttt gcatacagaa cccaacttga acgtcacatg acatcacata aatcaggaag     1080

agatcaaaga catgtgacgc agtctgggtg taatcgtaaa ttcaaatgca ctgagtgtgg     1140

aaaagctttc aaatacaaac atcacctaaa agagcactta agaattcaca gtggagagaa     1200

gccatatgaa tgcccaaact gcaagaaacg cttttcccat tctggctcct atagctcaca     1260

cataagcagt aagaaatgta tcagcttgat acctgtgaat gggcgaccaa gaacaggact     1320

caagacatct cagtgttctt caccgtctct ttcagcatca ccaggcagtc ccacacgacc     1380

acagatacgg caaaagatag agaataaacc ccttcaagaa caactttctg ttaaccaaat     1440

taaaactgaa cctgtggatt atgaattcaa acccatagtg gttgcttcag gaatcaactg     1500

ttcaacccct ttacaaaatg gggttttcac tggtggtggc ccattacagg caaccagttc     1560

tcctcagggc atggtgcaag ctgttgttct gccaacagtt ggtttggtgt ctcccataag     1620

tatcaattta agtgatattc agaatgtact taaagtggcg gtagatggta atgtaataag     1680

gcaagtgttg gagaataatc aagccaatct tgcatccaaa gaacaagaaa caatcaatgc     1740

ttcacccata caacaaggtg gccattctgt tatttcagcc atcagtcttc ctttggttga     1800

tcaagatgga acaaccaaaa ttatcatcaa ctacagtctt gagcagccta gccaacttca     1860

agttgttcct caaaatttaa aaaaagaaaa tccagtcgct acaaacagtt gtaaaagtga     1920

aaagttacca gaagatctta ctgttaagtc tgagaaggac aaaagctttg aagggggggt     1980

gaatgatagc acttgtcttc tgtgtgatga ttgtccagga gatattaatg cacttccaga     2040

attaaagcac tatgacctaa agcagcctac tcagcctcct ccactccctg cagcagaagc     2100

tgagaagcct gagtcctctg tttcatcagc tactggagat ggcaatttgt ctcctagtca     2160

gccaccttta aagaacctct tgtctctcct aaaagcatat tatgctttga atgcacaacc     2220

aagtgcagaa gagctctcaa aaattgctga ttcagtaaac ctaccactgg atgtagtaaa     2280

aaagtggttt gaaaagatgc aagctggaca gatttcagtg cagtcttctg aaccatcttc     2340

tcctgaacca ggcaaagtaa atatccctgc caagaacaat gatcagcctc aatctgcaaa     2400

tgcaaatgaa ccccaggaca gcacagtaaa tctacaaagt cctttgaaga tgactaactc     2460

cccagtttta ccagtgggat caaccaccaa tggttccaga agtagtacac catccccatc     2520

acctctaaac ctttcctcat ccagaaatac acagggttac ttgtacacag ctgagggtgc     2580

acaagaagag ccacaagtag aacctcttga tctttcacta ccaaagcaac agggagaatt     2640

attagaaagg tcaactatca ctagtgttta ccagaacagt gtttattctg tccaggaaga     2700

acccttgaac ttgtcttgcg caaaaaagga gccacaaaag gacagttgtg ttacagactc     2760

agaaccagtt gtaaatgtaa tcccaccaag tgccaacccc ataaatatcg ctatacctac     2820

agtcactgcc cagttaccca caatcgtggc cattgctgac cagaacagtg ttccatgctt     2880

aagagcgcta gctgccaata agcaaacgat tctgattccc caggtggcat acacctactc     2940

aactacggtc agccctgcag tccaagaacc acccttgaaa gtgatccagc caaatggaaa     3000

tcaggatgaa agacaagata ctagctcaga aggagtatca aatgtagagg atcagaatga     3060

ctctgattct acaccgccca aaaagaaaat gcggaagaca gaaaatggaa tgtatgcttg     3120

tgatttgtgt gacaagatat tccaaaagag tagttcatta ttgagacata aatatgaaca     3180

cacaggtaaa agacctcatg agtgtggaat ctgtaaaaag gcatttaaac acaaacatca     3240

tttgattgaa cacatgcgat tacattctgg agaaaagccc tatcaatgtg acaaatgtgg     3300

aaagcgcttc tcacactctg ggtcttattc tcaacacatg aatcatcgct actcctactg     3360

taagagagaa gcggaagaac gtgacagcac agagcaggaa gaggcagggc ctgaaatcct     3420

ctcgaatgag cacgtgggtg ccagggcgtc tccctcacag ggcgactcgg acgagagaga     3480

gagtttgaca agggaagagg atgaagacag tgaaaaagag gaagaggagg aggataaaga     3540

gatggaagaa ttgcaggaag aaaaagaatg tgaaaaacca caaggggatg aggaagagga     3600

ggaggaggag gaagaagtgg aagaagaaga ggtagaagag gcagagaatg agggagaaga     3660

agcaaaaact gaaggtctga tgaaggatga cagggctgaa agtcaagcaa gcagcttagg     3720

acaaaaagta ggcgagagta gtgagcaagt gtctgaagaa aagacaaatg aagcctaatc     3780

gtttttctag aaggaaaata aattctaatt gataatgaat ttcgttcaat attatccttg     3840

cttttcatgg aaacacagta acctgtatgc tgtgattcct gttcactact gtgtaaagta     3900

aaaactaaaa aaatacaaaa tacaaaacac acacacacac acacacacac acacacacac     3960

acacacaaaa taaatccggg tgtgcctgaa cctcagacct agtaattttt catgcagttt     4020

tcaaagttag gaacaagttt gtaacatgca gcagattaga aaaccttaat gactcagaga     4080

gcaacaatac aagaggttaa aggaagctga ttaattagat atgcatctgg cattgtttta     4140

tcttatcagt attatcactc ttatgttggt ttattcttaa gctgtacaat tgggagaaat     4200

tttataattt tttattggta aacatatgct aaatccgctt cagtatttta ttatgttttt     4260

taaaatgtga gaacttctgc actacaaaat tcccttcaca gagaagtata atgtagttcc     4320

aacccgtgct aactaccttt tataaattca gtctagaagg tagtaatttc taatatttag     4380

atgtcttagt agagcgtatt atcatttaaa gtgtattgtt agccttaaga aagcagctga     4440

tagaagaact gaagtttctt actcacgtgg tttaaaatgg agttcaaaag attgccattg     4500

agttctgatt gcagggacta acaatgttaa tctgataagg acagcaaaat catcagaatc     4560

agtgtttgtg attgtgtttg aatatgtggt aacatatgaa ggatatgaca tgaagctttg     4620

tatctccttt ggccttaagc aagacctgtg tgctgtaagt gccatttctc agtattttca     4680

aggctctaac ccgccttcat ccaatgtgtg gcctacaata actagcattt gttgatttgt     4740

ctcttgtatc aaaattccca aataaaactt aaaaccactg actctgtcag agaaactgaa     4800

acactgggac atttcatcct tcaattcctc ggtattgatt ttatgttgat tgattttcag     4860

aatttctcta cagaaacgaa agggaaattt tctaatctgc tttatccatg tacttgcatt     4920

tcagacatgg acatgctatt gttatttggc tcataactgt ttccaaatgt tagttattat     4980

ggacccaatt tattaacaac attagctgat ttttacctat cagtattatt ttatttcttt     5040

tagtttatag atctgtgcaa catttttgta ctgtatgtct tcaaacctgg cagtattaat     5100

acccttctta ctgacatatg tacttttagt tttagaaaac ttttatattt atgtgtctta     5160

tttttatatt tctttattta ttacacagtg tagtgtataa tactgtagtt tgtattaata     5220

caataatata ttttagtatg aaaatttgga aagttgataa gatttaaagt agagatgcaa     5280

ttggttctcc tgcattgaga tttgatttaa cagtgttatg ttaacattta tacttgcctt     5340

ggactgtaga acagaactta aatgggaatg tattagtttt acaactacaa tcaagtcatt     5400

ttacctttac ccagttttta atataaaact taaattttga aattcactgt gtgactaata     5460

gcatgatgct ctgcagtttt attaagaaat cagcctaacc atacaactct catttcctta     5520

gtaagccaaa ttaggattaa cttctataaa cagtgttggg aacaatgttt aacattttgt     5580

gccaatttgt tcctgtattc atgtatgtaa gttacagatc tgactcttca tttttaagtt     5640

ccttgttaca tcatggtcat tttctagttt tttaccagac tcccatctca caataaaatg     5700

catcaacaag cctgaa                                                     5716


<210> 118
<211> 906
<212> PRT
<213> Homo sapiens

<400> 118
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 119
<211> 6117
<212> DNA
<213> Homo sapiens

<400> 119
tttctccctc ccctctggga tgcgaaacgc gaggttttgt aacctttcct ggcaatttta       60

gattttgtgt gggatttcct gtctagaagc agatacgaag atttttaagc tgtttcaaga      120

tgtttccttc caatccataa ttatattttt aatatattcg agccatcatt aaaatcactg      180

ctttcgtgat tttaattatt caaataaaca cttgcatttt aaagacgtct gttgattata      240

aacgaaaggt attttggtat tctcattgtg gagagatgac ttgttatagc aaggagtgga      300

gcataggcta ttgcaatttt aatttcctgt tttagcgtca aatagtgtgt gttccatatt      360

gagctgttgc cgctgttgct gatgtggctt tatgaaagtt ttcagtttaa attctcaact      420

ggcaattggc cgaaaactcc catctgaaga catgatcatc caaatgtcat tttgtgattt      480

ggctactgtc tgcttgacat aggaaagcac tatcaagaaa gactaatgga gtgactatca      540

aaaggaagtc aatgatttct taagaattta caacaaaacc ctgtcaaagc agcattctta      600

cgtgagaatt tcacttacgg gagagttctt acaggatttc aagaaggaaa gccctgaaga      660

gggacactga tttcctcaac tgaatttaaa attgttacat gcagacattt ttaaaggaca      720

accttaaact tccaccacaa gaggaatata aagaggtccc tcctgcacca agaaagatct      780

gcagatcttt ttcagtgttc ttggaggtgt ggggtgtgag aacttgatca gtttgtgtca      840

gccaccttgt tctctaaagt tacaaattat aatactgtgg tagaaacaaa ttcagattca      900

gatgatgaag acaaactgca tattgtggaa gaagaaagtg ttacagatgc agctgactgt      960

gaaggtgtac cagaggatga cctgccaaca gaccagacag tgttaccagg gaggagcagt     1020

gaaagagaag ggaatgctaa gaactgctgg gaggatgaca caggaaagga agggcaagaa     1080

atcctggggc ctgaagctca ggcagatgaa gcaggatgta cagtaaaaga tgatgaatgc     1140

gagtcagatg cagaaaatga gcaaaaccat gatcctaatg ttgaagagtt tctacaacaa     1200

caagacactg ctgtcatttt tcctgaggca cctgaagagg accagaggca gggcacacca     1260

gaagccagtg gtcatgatga aaatggaaca ccagatgcat tttcacaatt actcacctgt     1320

ccatattgtg atagaggcta taaacgcttt acctctctga aagaacacat taaatatcgt     1380

catgaaaaga atgaagataa ctttagttgc tccctgtgca gttacacctt tgcatacaga     1440

acccaacttg aacgtcacat gacatcacat aaatcaggaa gagatcaaag acatgtgacg     1500

cagtctgggt gtaatcgtaa attcaaatgc actgagtgtg gaaaagcttt caaatacaaa     1560

catcacctaa aagagcactt aagaattcac agtggagaga agccatatga atgcccaaac     1620

tgcaagaaac gcttttccca ttctggctcc tatagctcac acataagcag taagaaatgt     1680

atcagcttga tacctgtgaa tgggcgacca agaacaggac tcaagacatc tcagtgttct     1740

tcaccgtctc tttcagcatc accaggcagt cccacacgac cacagatacg gcaaaagata     1800

gagaataaac cccttcaaga acaactttct gttaaccaaa ttaaaactga acctgtggat     1860

tatgaattca aacccatagt ggttgcttca ggaatcaact gttcaacccc tttacaaaat     1920

ggggttttca ctggtggtgg cccattacag gcaaccagtt ctcctcaggg catggtgcaa     1980

gctgttgttc tgccaacagt tggtttggtg tctcccataa gtatcaattt aagtgatatt     2040

cagaatgtac ttaaagtggc ggtagatggt aatgtaataa ggcaagtgtt ggagaataat     2100

caagccaatc ttgcatccaa agaacaagaa acaatcaatg cttcacccat acaacaaggt     2160

ggccattctg ttatttcagc catcagtctt cctttggttg atcaagatgg aacaaccaaa     2220

attatcatca actacagtct tgagcagcct agccaacttc aagttgttcc tcaaaattta     2280

aaaaaagaaa atccagtcgc tacaaacagt tgtaaaagtg aaaagttacc agaagatctt     2340

actgttaagt ctgagaagga caaaagcttt gaaggggggg tgaatgatag cacttgtctt     2400

ctgtgtgatg attgtccagg agatattaat gcacttccag aattaaagca ctatgaccta     2460

aagcagccta ctcagcctcc tccactccct gcagcagaag ctgagaagcc tgagtcctct     2520

gtttcatcag ctactggaga tggcaatttg tctcctagtc agccaccttt aaagaacctc     2580

ttgtctctcc taaaagcata ttatgctttg aatgcacaac caagtgcaga agagctctca     2640

aaaattgctg attcagtaaa cctaccactg gatgtagtaa aaaagtggtt tgaaaagatg     2700

caagctggac agatttcagt gcagtcttct gaaccatctt ctcctgaacc aggcaaagta     2760

aatatccctg ccaagaacaa tgatcagcct caatctgcaa atgcaaatga accccaggac     2820

agcacagtaa atctacaaag tcctttgaag atgactaact ccccagtttt accagtggga     2880

tcaaccacca atggttccag aagtagtaca ccatccccat cacctctaaa cctttcctca     2940

tccagaaata cacagggtta cttgtacaca gctgagggtg cacaagaaga gccacaagta     3000

gaacctcttg atctttcact accaaagcaa cagggagaat tattagaaag gtcaactatc     3060

actagtgttt accagaacag tgtttattct gtccaggaag aacccttgaa cttgtcttgc     3120

gcaaaaaagg agccacaaaa ggacagttgt gttacagact cagaaccagt tgtaaatgta     3180

atcccaccaa gtgccaaccc cataaatatc gctataccta cagtcactgc ccagttaccc     3240

acaatcgtgg ccattgctga ccagaacagt gttccatgct taagagcgct agctgccaat     3300

aagcaaacga ttctgattcc ccaggtggca tacacctact caactacggt cagccctgca     3360

gtccaagaac cacccttgaa agtgatccag ccaaatggaa atcaggatga aagacaagat     3420

actagctcag aaggagtatc aaatgtagag gatcagaatg actctgattc tacaccgccc     3480

aaaaagaaaa tgcggaagac agaaaatgga atgtatgctt gtgatttgtg tgacaagata     3540

ttccaaaaga gtagttcatt attgagacat aaatatgaac acacaggtaa aagacctcat     3600

gagtgtggaa tctgtaaaaa ggcatttaaa cacaaacatc atttgattga acacatgcga     3660

ttacattctg gagaaaagcc ctatcaatgt gacaaatgtg gaaagcgctt ctcacactct     3720

gggtcttatt ctcaacacat gaatcatcgc tactcctact gtaagagaga agcggaagaa     3780

cgtgacagca cagagcagga agaggcaggg cctgaaatcc tctcgaatga gcacgtgggt     3840

gccagggcgt ctccctcaca gggcgactcg gacgagagag agagtttgac aagggaagag     3900

gatgaagaca gtgaaaaaga ggaagaggag gaggataaag agatggaaga attgcaggaa     3960

gaaaaagaat gtgaaaaacc acaaggggat gaggaagagg aggaggagga ggaagaagtg     4020

gaagaagaag aggtagaaga ggcagagaat gagggagaag aagcaaaaac tgaaggtctg     4080

atgaaggatg acagggctga aagtcaagca agcagcttag gacaaaaagt aggcgagagt     4140

agtgagcaag tgtctgaaga aaagacaaat gaagcctaat cgtttttcta gaaggaaaat     4200

aaattctaat tgataatgaa tttcgttcaa tattatcctt gcttttcatg gaaacacagt     4260

aacctgtatg ctgtgattcc tgttcactac tgtgtaaagt aaaaactaaa aaaatacaaa     4320

atacaaaaca cacacacaca cacacacaca cacacacaca cacacacaaa ataaatccgg     4380

gtgtgcctga acctcagacc tagtaatttt tcatgcagtt ttcaaagtta ggaacaagtt     4440

tgtaacatgc agcagattag aaaaccttaa tgactcagag agcaacaata caagaggtta     4500

aaggaagctg attaattaga tatgcatctg gcattgtttt atcttatcag tattatcact     4560

cttatgttgg tttattctta agctgtacaa ttgggagaaa ttttataatt ttttattggt     4620

aaacatatgc taaatccgct tcagtatttt attatgtttt ttaaaatgtg agaacttctg     4680

cactacaaaa ttcccttcac agagaagtat aatgtagttc caacccgtgc taactacctt     4740

ttataaattc agtctagaag gtagtaattt ctaatattta gatgtcttag tagagcgtat     4800

tatcatttaa agtgtattgt tagccttaag aaagcagctg atagaagaac tgaagtttct     4860

tactcacgtg gtttaaaatg gagttcaaaa gattgccatt gagttctgat tgcagggact     4920

aacaatgtta atctgataag gacagcaaaa tcatcagaat cagtgtttgt gattgtgttt     4980

gaatatgtgg taacatatga aggatatgac atgaagcttt gtatctcctt tggccttaag     5040

caagacctgt gtgctgtaag tgccatttct cagtattttc aaggctctaa cccgccttca     5100

tccaatgtgt ggcctacaat aactagcatt tgttgatttg tctcttgtat caaaattccc     5160

aaataaaact taaaaccact gactctgtca gagaaactga aacactggga catttcatcc     5220

ttcaattcct cggtattgat tttatgttga ttgattttca gaatttctct acagaaacga     5280

aagggaaatt ttctaatctg ctttatccat gtacttgcat ttcagacatg gacatgctat     5340

tgttatttgg ctcataactg tttccaaatg ttagttatta tggacccaat ttattaacaa     5400

cattagctga tttttaccta tcagtattat tttatttctt ttagtttata gatctgtgca     5460

acatttttgt actgtatgtc ttcaaacctg gcagtattaa tacccttctt actgacatat     5520

gtacttttag ttttagaaaa cttttatatt tatgtgtctt atttttatat ttctttattt     5580

attacacagt gtagtgtata atactgtagt ttgtattaat acaataatat attttagtat     5640

gaaaatttgg aaagttgata agatttaaag tagagatgca attggttctc ctgcattgag     5700

atttgattta acagtgttat gttaacattt atacttgcct tggactgtag aacagaactt     5760

aaatgggaat gtattagttt tacaactaca atcaagtcat tttaccttta cccagttttt     5820

aatataaaac ttaaattttg aaattcactg tgtgactaat agcatgatgc tctgcagttt     5880

tattaagaaa tcagcctaac catacaactc tcatttcctt agtaagccaa attaggatta     5940

acttctataa acagtgttgg gaacaatgtt taacattttg tgccaatttg ttcctgtatt     6000

catgtatgta agttacagat ctgactcttc atttttaagt tccttgttac atcatggtca     6060

ttttctagtt ttttaccaga ctcccatctc acaataaaat gcatcaacaa gcctgaa        6117


<210> 120
<211> 906
<212> PRT
<213> Homo sapiens

<400> 120
Met Thr Ser His Lys Ser Gly Arg Asp Gln Arg His Val Thr Gln Ser 
1               5                   10                  15      


Gly Cys Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly Lys Ala Phe Lys 
            20                  25                  30          


Tyr Lys His His Leu Lys Glu His Leu Arg Ile His Ser Gly Glu Lys 
        35                  40                  45              


Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser His Ser Gly Ser 
    50                  55                  60                  


Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Ser Leu Ile Pro Val 
65                  70                  75                  80  


Asn Gly Arg Pro Arg Thr Gly Leu Lys Thr Ser Gln Cys Ser Ser Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Pro Gly Ser Pro Thr Arg Pro Gln Ile Arg Gln 
            100                 105                 110         


Lys Ile Glu Asn Lys Pro Leu Gln Glu Gln Leu Ser Val Asn Gln Ile 
        115                 120                 125             


Lys Thr Glu Pro Val Asp Tyr Glu Phe Lys Pro Ile Val Val Ala Ser 
    130                 135                 140                 


Gly Ile Asn Cys Ser Thr Pro Leu Gln Asn Gly Val Phe Thr Gly Gly 
145                 150                 155                 160 


Gly Pro Leu Gln Ala Thr Ser Ser Pro Gln Gly Met Val Gln Ala Val 
                165                 170                 175     


Val Leu Pro Thr Val Gly Leu Val Ser Pro Ile Ser Ile Asn Leu Ser 
            180                 185                 190         


Asp Ile Gln Asn Val Leu Lys Val Ala Val Asp Gly Asn Val Ile Arg 
        195                 200                 205             


Gln Val Leu Glu Asn Asn Gln Ala Asn Leu Ala Ser Lys Glu Gln Glu 
    210                 215                 220                 


Thr Ile Asn Ala Ser Pro Ile Gln Gln Gly Gly His Ser Val Ile Ser 
225                 230                 235                 240 


Ala Ile Ser Leu Pro Leu Val Asp Gln Asp Gly Thr Thr Lys Ile Ile 
                245                 250                 255     


Ile Asn Tyr Ser Leu Glu Gln Pro Ser Gln Leu Gln Val Val Pro Gln 
            260                 265                 270         


Asn Leu Lys Lys Glu Asn Pro Val Ala Thr Asn Ser Cys Lys Ser Glu 
        275                 280                 285             


Lys Leu Pro Glu Asp Leu Thr Val Lys Ser Glu Lys Asp Lys Ser Phe 
    290                 295                 300                 


Glu Gly Gly Val Asn Asp Ser Thr Cys Leu Leu Cys Asp Asp Cys Pro 
305                 310                 315                 320 


Gly Asp Ile Asn Ala Leu Pro Glu Leu Lys His Tyr Asp Leu Lys Gln 
                325                 330                 335     


Pro Thr Gln Pro Pro Pro Leu Pro Ala Ala Glu Ala Glu Lys Pro Glu 
            340                 345                 350         


Ser Ser Val Ser Ser Ala Thr Gly Asp Gly Asn Leu Ser Pro Ser Gln 
        355                 360                 365             


Pro Pro Leu Lys Asn Leu Leu Ser Leu Leu Lys Ala Tyr Tyr Ala Leu 
    370                 375                 380                 


Asn Ala Gln Pro Ser Ala Glu Glu Leu Ser Lys Ile Ala Asp Ser Val 
385                 390                 395                 400 


Asn Leu Pro Leu Asp Val Val Lys Lys Trp Phe Glu Lys Met Gln Ala 
                405                 410                 415     


Gly Gln Ile Ser Val Gln Ser Ser Glu Pro Ser Ser Pro Glu Pro Gly 
            420                 425                 430         


Lys Val Asn Ile Pro Ala Lys Asn Asn Asp Gln Pro Gln Ser Ala Asn 
        435                 440                 445             


Ala Asn Glu Pro Gln Asp Ser Thr Val Asn Leu Gln Ser Pro Leu Lys 
    450                 455                 460                 


Met Thr Asn Ser Pro Val Leu Pro Val Gly Ser Thr Thr Asn Gly Ser 
465                 470                 475                 480 


Arg Ser Ser Thr Pro Ser Pro Ser Pro Leu Asn Leu Ser Ser Ser Arg 
                485                 490                 495     


Asn Thr Gln Gly Tyr Leu Tyr Thr Ala Glu Gly Ala Gln Glu Glu Pro 
            500                 505                 510         


Gln Val Glu Pro Leu Asp Leu Ser Leu Pro Lys Gln Gln Gly Glu Leu 
        515                 520                 525             


Leu Glu Arg Ser Thr Ile Thr Ser Val Tyr Gln Asn Ser Val Tyr Ser 
    530                 535                 540                 


Val Gln Glu Glu Pro Leu Asn Leu Ser Cys Ala Lys Lys Glu Pro Gln 
545                 550                 555                 560 


Lys Asp Ser Cys Val Thr Asp Ser Glu Pro Val Val Asn Val Ile Pro 
                565                 570                 575     


Pro Ser Ala Asn Pro Ile Asn Ile Ala Ile Pro Thr Val Thr Ala Gln 
            580                 585                 590         


Leu Pro Thr Ile Val Ala Ile Ala Asp Gln Asn Ser Val Pro Cys Leu 
        595                 600                 605             


Arg Ala Leu Ala Ala Asn Lys Gln Thr Ile Leu Ile Pro Gln Val Ala 
    610                 615                 620                 


Tyr Thr Tyr Ser Thr Thr Val Ser Pro Ala Val Gln Glu Pro Pro Leu 
625                 630                 635                 640 


Lys Val Ile Gln Pro Asn Gly Asn Gln Asp Glu Arg Gln Asp Thr Ser 
                645                 650                 655     


Ser Glu Gly Val Ser Asn Val Glu Asp Gln Asn Asp Ser Asp Ser Thr 
            660                 665                 670         


Pro Pro Lys Lys Lys Met Arg Lys Thr Glu Asn Gly Met Tyr Ala Cys 
        675                 680                 685             


Asp Leu Cys Asp Lys Ile Phe Gln Lys Ser Ser Ser Leu Leu Arg His 
    690                 695                 700                 


Lys Tyr Glu His Thr Gly Lys Arg Pro His Glu Cys Gly Ile Cys Lys 
705                 710                 715                 720 


Lys Ala Phe Lys His Lys His His Leu Ile Glu His Met Arg Leu His 
                725                 730                 735     


Ser Gly Glu Lys Pro Tyr Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser 
            740                 745                 750         


His Ser Gly Ser Tyr Ser Gln His Met Asn His Arg Tyr Ser Tyr Cys 
        755                 760                 765             


Lys Arg Glu Ala Glu Glu Arg Asp Ser Thr Glu Gln Glu Glu Ala Gly 
    770                 775                 780                 


Pro Glu Ile Leu Ser Asn Glu His Val Gly Ala Arg Ala Ser Pro Ser 
785                 790                 795                 800 


Gln Gly Asp Ser Asp Glu Arg Glu Ser Leu Thr Arg Glu Glu Asp Glu 
                805                 810                 815     


Asp Ser Glu Lys Glu Glu Glu Glu Glu Asp Lys Glu Met Glu Glu Leu 
            820                 825                 830         


Gln Glu Glu Lys Glu Cys Glu Lys Pro Gln Gly Asp Glu Glu Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu Ala Glu Asn 
    850                 855                 860                 


Glu Gly Glu Glu Ala Lys Thr Glu Gly Leu Met Lys Asp Asp Arg Ala 
865                 870                 875                 880 


Glu Ser Gln Ala Ser Ser Leu Gly Gln Lys Val Gly Glu Ser Ser Glu 
                885                 890                 895     


Gln Val Ser Glu Glu Lys Thr Asn Glu Ala 
            900                 905     


<210> 121
<211> 18697
<212> DNA
<213> Homo sapiens

<400> 121
agagcctggc ccggcgccag cagcctgagg aatgtggtgg ttggagccgg tgactaattc       60

aaaccagaac tcagggagga gtggttgtga ccgagattcc cgacgagaga gactgagggg      120

aagagaggaa ggaggggcgg gctcctggca aggcattcgc tcctgagcgg aatcctgcaa      180

agatggagaa ggaggagaca acccgggagc tgctgctgcc caactggcag ggtagtggct      240

cccacgggct gaccatcgcc cagagggacg acggcgtctt tgtgcaggag gtgacgcaga      300

actcccctgc ggcccgcact ggggtggtca aggaggggga ccagattgtg ggtgccacca      360

tctactttga caacctgcag tcgggtgagg tgacccagct gctgaacacc atggggcacc      420

acacggtggg cctgaagctg caccgcaagg gggaccgctc tcccgagcct ggccagacct      480

ggacccgtga agtcttcagc tcctgcagct ctgaagtggt tctgagcggg gatgatgagg      540

agtaccagcg catctacacc acgaagatca agccacggct gaagtcggaa gatggagtgg      600

aaggagacct cggggagacc cagagccgta ccatcacagt gaccagaagg gtcacggcct      660

acactgtgga tgtgactggc cgggaaggag ccaaggacat agacatcagt agccctgaat      720

tcaagatcaa gattccaaga catgaactga ctgaaatctc caatgtggat gtggagaccc      780

agtctgggaa gaccgtgatc agactgccct cgggctcggg ggcagcctct ccgacaggct      840

ctgctgtgga tatccgagca ggggccattt ctgcttcagg accagagctc caaggtgctg      900

gccactcgaa gctccaggtc accatgcctg ggataaaggt gggaggctca ggtgtcaatg      960

tcaatgcaaa gggcttggac ttgggtggca gaggaggggt ccaagttcca gcagtggaca     1020

tttcatcttc tcttgggggt agggcagtag aggtacaggg cccatctctg gagagtggtg     1080

atcatggcaa aattaaattt cccaccatga aagtgccgaa atttggtgtc tcaacagggc     1140

gtgagggcca gacaccaaag gcagggctga gggtttctgc acctgaagtc tctgtggggc     1200

acaagggcgg caagccaggc ttgactatcc aagcccctca gctggaagtc agtgtgccct     1260

ctgccaatat tgagggcctt gaggggaagc tgaagggccc ccaaatcact gggccatcac     1320

ttgagggtga cctaggcctg aaaggtgcca agccacaggg gcacattggg gtggatgcct     1380

ctgctcccca aattgggggt agcatcactg gccccagtgt ggaagttcag gcccctgaca     1440

ttgatgttca ggggcctggg agcaaactga atgtgcccaa gatgaaagtc cccaagttct     1500

ctgtatcagg tgcaaaggga gaggaaactg ggattgatgt gacactgcct acaggtgaag     1560

tgactgttcc tggggtctct ggggatgtca gcctgcctga gattgctact ggtgggctgg     1620

aaggaaagat gaaaggtact aaagtgaaga ctcctgaaat gattattcag aaacctaaaa     1680

tctccatgca ggatgtggat ctgagccttg ggtctcctaa actgaaagga gatattaagg     1740

tttctgctcc tggggtgcaa ggtgatgtta aaggccctca agtggcactt aaaggctcca     1800

gagtggacat agagacacca aacctagagg gaaccttgac aggccctagg cttggcagtc     1860

cttccgggaa aaccggaacc tgtaggatct ctatgtcaga agtagactta aatgtggccg     1920

cacctaaagt gaaagggggt gtagatgtca cactccccag agtagaaggg aaagtcaaag     1980

tccctgaagt tgatgtcaga ggccccaaag tggatgtcag tgccccagat gtcgaagcgc     2040

atggcccaga atggaacctg aaaatgccca agatgaaaat gcccacgttc agcactccag     2100

gagccaaagg ggaaggtcca gatgttcata tgactctacc caaaggagat atcagtattt     2160

cagggcccaa ggtcaatgtg gaagccccag atgtcaactt ggagggtctg gggggaaaac     2220

ttaaaggccc cgatgttaag ctgcctgata tgagtgtcaa gacaccaaag atctccatgc     2280

ctgatgtaga tttgcacgtg aaaggtacaa aggtgaaggg agagtatgat gtaactgtac     2340

caaagctgga aggagaactc aaaggcccaa aagtggacat tgatgcccca gatgtggatg     2400

ttcatggccc agactggcac ttgaagatgc ccaagatgaa aatgcccaaa ttcagtgtgc     2460

cagggttcaa agcagagggc ccagaagtgg atgtgaacct gcccaaggct gatgtggaca     2520

tttccgggcc caagatagat gttactgctc ctgatgtgag cattgaggaa ccagaaggga     2580

aattgaaagg gcccaagttt aagatgcctg agatgaacat caaagtcccc aagatctcca     2640

tgcctgatgt ggacttacat ctgaaaggcc ctaacgtaaa gggagaatat gatgtcacaa     2700

tgccaaaggt tgaaagtgag attaaagttc ctgatgttga acttaaaagt gccaaaatgg     2760

acattgatgt cccagatgtg gaggttcaag gcccagactg gcacctgaag atgcccaaga     2820

tgaaaatgcc caagttcagc atgcctggct tcaaagcaga gggcccagaa gtggatgtga     2880

acctgcccaa ggctgatgtg gacatctcag gacccaaggt gggtgttgaa gttccagatg     2940

tgaatattga aggacctgaa ggaaagctga agggccccaa gttcaagatg ccagagatga     3000

atatcaaggc ccccaagatc tccatgcctg atgtggactt gcatatgaaa ggtcctaaag     3060

taaagggaga atatgatatg acagtgccaa agctggaagg ggacctgaaa ggcccaaaag     3120

tagatgtcag tgccccagat gttgaaatgc agggtcctga ctggaacttg aagatgccaa     3180

agattaaaat gcccaaattt agcatgccca gcctcaaagg agaggggcca gaatttgatg     3240

tgaacctgtc caaagcgaat gtggacattt ctgcaccaaa agtagatact aatgctccag     3300

atctgagcct tgaaggacct gaagggaagt tgaaaggccc gaagtttaag atgcctgaga     3360

tgcacttcag agctcctaag atgtctttgc cagatgttga cctggatctt aaaggaccca     3420

aaatgaaagg aaatgtagat atctctgcac caaagataga gggtgaaatg caggttccag     3480

atgtggacat cagaggtccc aaggtagata ttaaagcacc agatgtggaa ggccaaggcc     3540

tggactggag cctgaaaata cccaagatga aaatgcccaa gttcagcatg cccagcctca     3600

aaggcgaggg cccagaagtg gatgtgaact tgcctaaggc tgacgttgtt gtctcaggac     3660

ccaaggtgga catcgaagcc ccagatgtga gcctcgaagg tccagaaggg aagctgaagg     3720

gtcccaagtt taagatgcct gagatgcatt tcaagacccc caagatctcc atgcctgatg     3780

tggacttaca cttgaaaggc cccaaagtca aaggggatgt ggatgtgtct gtgcccaagg     3840

tagaaggtga aatgaaagtg ccagatgttg aaatcaaagg acccaaaatg gacattgatg     3900

ccccagatgt ggaggttcaa ggcccagact ggcacctgaa gatgcccaag atgaaaatgc     3960

ccaagtttag catgcctggc ttcaaaggag agggccgaga agtggatgtg aacctgccca     4020

aggctgacat tgatgtctca ggacccaagg tggatgttga agtcccagat gtgagccttg     4080

agggcccgga aggaaagctg aagggcccca agtttaagat gcctgagatg cacttcaagg     4140

cccccaagat ctccatgcct gatgtggacc tgaatcttaa ggggccaaaa ttgaagggag     4200

atgtggatgt gtccttgcct gaggtagaag gtgaaatgaa agtgccagat gttgacatta     4260

aagggcccaa agttgacatt agtgctccag atgtggatgt tcatggccca gattggcacc     4320

tgaagatgcc caaggtgaaa atgcccaagt tcagcatgcc cggcttcaaa ggagagggcc     4380

ctgaagtgga tgtgaagctg cccaaagctg acgttgatgt ctcaggaccc aaaatggatg     4440

ctgaagttcc agatgtgaat attgaaggtc cagacgcaaa actaaaaggt cccaaattca     4500

agatgccaga aatgagtata aagcctcaga agatatccat accagatgtt ggtttgcatt     4560

tgaaaggtcc taaaatgaaa ggagattatg atgtaacagt tccaaaagta gaaggagaga     4620

taaaagctcc tgatgttgac atcaaaggcc ccaaagttga tattaatgca ccagatgtgg     4680

aggttcatgg cccagactgg cacctgaaga tgcccaaggt aaaaatgccc aagttcagca     4740

tgcctggctt taaaggagag ggcccagagg tggatatgaa cctgcccaag gctgaccttg     4800

gtgtttcagg acccaaggtg gacattgatg ttccagatgt gaatcttgaa gctccagagg     4860

ggaaactaaa aggccctaag ttcaagatgc caagcatgaa tatacagacg cacaaaatct     4920

ctatgcctga tgttggactt aatttgaaag cccctaaact gaaaactgat gtagatgttt     4980

cccttcccaa agtggaagga gacttgaagg gtcctgaaat tgatgtgaaa gcccctaaga     5040

tggatgtgaa tgttggtgat attgatattg aaggtccaga agggaagttg aagggcccca     5100

agtttaagat gcctgagatg catttcaagg cccccaagat ctccatgccc gatgtggact     5160

tacacttgaa aggccccaaa gtcaaagggg atatggatgt gtctgtgccc aaggtagaag     5220

gtgaaatgaa agtgccagat gttgacatta aagggcccaa agtggacatt gatgccccag     5280

atgtggaggt tcacgaccca gattggcacc tgaaaatgcc caagatgaaa atgcccaagt     5340

tcagtatgcc tggcttcaaa gcagagggcc ctgaagtgga tgtgaatctg ccaaaggctg     5400

acattgatgt gtctggaccc agtgtggaca ctgatgctcc tgatttggat attgagggac     5460

cagaaggaaa gttgaaaggc tccaaattta agatgcccaa gttgaatata aaagctccca     5520

aggtctccat gccagatgtg gacttgaatt tgaagggacc caaactgaag ggagagatag     5580

atgcttctgt gccagaactg gaaggtgatc tcagagggcc gcaagttgat gtcaaaggtc     5640

cttttgtgga agcggaggtg cccgatgttg atctggagtg tcctgatgca aagttgaaag     5700

ggcccaagtt taagatgcct gagatgcact tcaaggcccc caagatctcc atgcctgatg     5760

tggacttaca cctgaaaggc cccaaagtca aaggggatgc ggatgtgtcg gtgccaaaat     5820

tggagggaga tttaacaggc cccagtgtgg gtgtggaggt gcctgatgtt gagctggagt     5880

gtcctgatgc aaagttgaaa ggccctaaat ttaagatgcc agacatgcac ttcaaggccc     5940

ccaagatctc catgcctgat gtggacttac acttgaaagg ccccaaagtc aaaggggatg     6000

tggatgtgtc ggtgccaaaa ttggagggag atttaacagg tcccagtgtg ggtgtggagg     6060

tgcctgatgt tgagctggag tgtcctgatg caaagttgaa agggcccaag tttaagatgc     6120

ctgagatgca cttcaagacc cccaagatct ccatgcctga tgtggactta cacctgaaag     6180

gccccaaagt caaaggggat atggatgtgt ctgtgcccaa ggtagaaggt gaaatgaaag     6240

tgccagatgt tgacatcaaa ggacccaaaa tggacattga tgccccagat gtggatgttc     6300

atggcccaga ctggcacctg aagatgccca agatgaaaat gcccaagttc agcatgcctg     6360

gcttcaaagc agagggccca gaagtggatg tgaacttgcc caaggctgat gttgttgtct     6420

caggacccaa ggtggatgtt gaagtcccag atgtgagcct tgaaggtcca gaagggaagc     6480

tgaagggccc caagcttaag atgcctgaga tgcacttcaa ggcccccaag atctccatgc     6540

ctgatgtgga cttacacttg aaaggcccca aagtcaaagg ggatgtggat gtgtctttgc     6600

caaaattgga gggagattta acaggcccca gtgtggatgt ggaggtgcct gatgttgagc     6660

tggagtgtcc tgatgcaaag ttgaaagggc ccaagtttaa gatgcctgag atgcacttca     6720

agacccccaa gatctccatg cctgatgtga acttaaactt gaaaggcccc aaagtcaaag     6780

gggatatgga tgtgtctgtt cccaaggtag aaggtgaaat gaaagtgcca gatgttgaca     6840

tcagagggcc caaagtggac attgatgccc cagatgtgga tgttcatggc ccagactggc     6900

acctgaagat gcctaagatg aaaatgccca agttcagcat gcctggcttc aaaggagagg     6960

gcccagaagt ggatgtgaac ttgcccaagg ctgacgttga tgtctcagga cccaaggtgg     7020

atgttgaagt cccagatgtg agccttgaag gtccagaagg gaagctgaag ggccccaagt     7080

ttaagatgcc tgagatgcac ttcaagaccc ccaagatctc catgcctgat gttgatttca     7140

atttaaaggg acccaaaatc aaaggagatg ttgatgtttc tgccccaaag ctggagggag     7200

agttaaaagg tccagaattg gatgtcaaag gtcccaaatt agatgctgac atgccagaag     7260

tagctgtgga aggcccaaat ggcaagtgga aaactcctaa gttcaagatg ccagatatgc     7320

actttaaagc tcccaaaatc tctatgccag acctcgatct acacttgaag agccccaagg     7380

caaaaggaga ggtggatgta gatgttccca aattggaagg ggaccttaaa gggccacatg     7440

tggatgtcag tgggccagac attgacattg agggaccaga gggcaaattg aaaggcccta     7500

agttcaagat gcctgatatg catttcaaag cccccaatat ttctatgcct gatgttgatc     7560

taaatctcaa aggacccaaa atcaaggggg atgtggatgt gtctgtgcct gaggtagaag     7620

gtaaacttga agtaccagat atgaacatca ggggccccaa agttgatgta aatgcccccg     7680

atgtccaagc tccagactgg cacctgaaga tgcccaagat gaaaatgccc aagttcagca     7740

tgcctggctt caaagcagag ggccctgaag tagacgtcaa cttgcctaag gctgacgttg     7800

acatctcagg acccaaggtg gacattgaag gccctgatgt taatattgaa ggaccagagg     7860

gaaagttgaa agggcctaag ttaaagatgc cagagatgaa catcaaagcc cccaagatct     7920

ccatgcctga ctttgatttg catctgaaag gtcccaaggt gaagggcgat gtggatgttt     7980

ctctgcccaa agtggaaggt gacctcaagg gccccgaagt tgacatcaag gggcccaaag     8040

tggatattaa tgccccagat gtgggtgttc aaggcccaga ctggcacctg aagatgccca     8100

aggtgaaaat gccaaagttc agcatgcctg gcttcaaagg agagggccca gatggggatg     8160

tgaagctgcc caaggctgac attgatgtct caggacccaa agtggacatt gaaggccctg     8220

atgttaacat tgaaggacca gagggaaagt tgaaagggcc taagttcaag atgccagaga     8280

tgaatatcaa agcccccaag atctccatgc ctgatattga cttaaacctg aaaggaccca     8340

aagtgaaggg tgatgtggat gtttcccttc ctaaagtgga aggtgacctc aagggcccag     8400

aagttgacat caagggccca aaagtggaca ttgacgcacc tgatgttgat gttcatggcc     8460

cagactggca cctaaagatg cccaagataa aaatgcccaa gatcagcatg cctggcttca     8520

aaggagaagg tccagatgtg gacgtgaacc tgcccaaggc tgacattgat gtctcaggac     8580

cgaaagtgga tgttgaatgt cccgatgtga atatcgaagg acctgaagga aagtggaaaa     8640

gtccaaagtt taagatgcca gagatgcatt ttaagactcc aaagatatcc atgccagata     8700

ttgacctgaa tctcacaggt ccaaaaataa aaggagatgt ggatgttaca ggccctaagg     8760

tagagggaga tctgaaaggt cctgaagttg acctcaaagg ccccaaagtg gacattgatg     8820

tcccagatgt taatgttcag ggtccagact ggcacctgaa gatgcccaag atgaaaatgc     8880

ccaagttcag catgcctggc ttcaaagcag agggccctga agtggatgtg aacctgccca     8940

aggctgacgt tgatgtctca ggccccaaag tggacgttga aggccctgat gttaacattg     9000

aaggaccaga gggaaagttg aaagggccca agttcaagat gccagagatg aatatcaaag     9060

cccccaagat ccccatgcct gactttgatt tgcatctgaa aggtcccaag gtgaagggcg     9120

atgtggatat ttctctgccc aaagtggaag gtgacctcaa gggccctgaa gttgacatca     9180

ggggtcccca agtggacatt gatgtcccgg atgtgggcgt tcaaggccca gactggcacc     9240

taaaaatgcc caaagtgaaa atgcccaaat tcagcatgcc tggcttcaaa ggagagggcc     9300

cagatgtgga tgtgaacctg cccaaggctg accttgatgt ctcaggaccc aaggtggaca     9360

ttgatgttcc agatgtgaat atcgaaggcc cagagggaaa gttgaaaggt cccaaattca     9420

aaatgcctga gatgaacatc aaagccccca agatctccat gcctgacatt gatcttaacc     9480

tgaaaggtcc caaagtgaag ggtgacatgg atgtgtctct gccaaaagtg gaaggtgaca     9540

tgaaagttcc tgacgtggat attaaaggcc ccaaagtgga tattaatgcc ccagatgtgg     9600

atgttcaagg cccagactgg cacctgaaga tgcctaaaat aaaaatgccc aagatcagca     9660

tgcctggctt caaaggagaa ggtccagaag tggacgtgaa cctgcccaag gctgaccttg     9720

acgtctcagg acccaaggtg gacgttgatg ttccagatgt gaatattgaa ggtccagatg     9780

cgaaactgaa gggccctaaa ttcaagatgc cagagatgaa catcaaagct cctaaaatat     9840

caatgcctga tttggacctc aatcttaaag gccctaaaat gaaaggagag gtggatgttt     9900

cacttgcaaa tgtagaaggt gatttgaaag gacctgctct tgacataaaa ggcccaaaga     9960

tagatgtaga tgctccagat attgacattc atggcccaga tgccaaatta aaaggtccaa    10020

aactgaagat gcctgacatg catgtaaaca tgcccaagat ctccatgcca gaaattgact    10080

tgaatttgaa aggctcaaag cttaagggag atgttgatgt ctctgggccc aagttggaag    10140

gtgacattaa agctcccagt ttggatataa agggcccaga agtggacgtt tccggtccta    10200

agcttaatat cgaaggcaag tcaaagaaat ctcgttttaa gcttcccaaa tttaattttt    10260

cgggctctaa agttcagaca cctgaagtgg atgtcaaagg taaaaagcca gatattgaca    10320

taacaggtcc aaaagttgat attaatgctc ctgatgtcga ggtccaagga aaagtgaaag    10380

gatccaagtt taaaatgcct ttcctgagta tttcatctcc caaagtttct atgcctgacg    10440

tggagctaaa tttgaaaagt cccaaagtca aaggagactt agatattgca ggtcccaatt    10500

tagaaggtga ctttaaaggc cccaaagtgg atattaaggc accagaagtc aatcttaatg    10560

cacctgatgt ggatgttcat ggtccagact ggaatctgaa aatgcccaag atgaaaatgc    10620

ccaaattcag tgtgtctggc ttaaaagcag aagggccaga tgtagctgtg gatctaccaa    10680

aaggagacat caacatagag ggcccaagta tgaacattga gggcccagat ctcaatgtgg    10740

aaggtccgga gggaggcttg aaaggtccca aattcaagat gcctgacatg aatatcaaag    10800

ctcccaagat ctccatgcct gacattgact taaacttgaa aggccccaag gtgaaaggtg    10860

atgtggatat ttctcttccc aaacttgaag gggatctgaa agggccagag gttgatatca    10920

aaggccctaa agtggacatc aatgccccag atgtggatgt tcatggtcca gactggcatc    10980

tgaagatgcc caaagtgaaa atgcccaagt tcagcatgcc tggcttcaaa ggagaaggcc    11040

ctgaagtcga tgttaccctc cctaaagctg acattgacat ttctggtccc aatgtagacg    11100

ttgatgttcc agacgtgaat attgaaggtc cagatgcaaa gctgaagggc cccaagttca    11160

agatgcctga gatgaacatc aaagccccca agatctccat gcctgacttt gacctgaact    11220

tgaagggacc caaaatgaag ggtgatgtgg ttgtgtcttt gcccaaagtg gaaggtgatc    11280

taaaaggccc tgaggtggac atcaagggcc ccaaagtgga cattgacact cctgacatta    11340

acatcgaagg ctcagagggt aaattcaagg gacccaaatt taagatacca gagatgcacc    11400

tgaaggctcc caaaatatcg atgcctgaca ttgatttaaa cctgaagggc cccaaagtca    11460

agggcgatgt ggatgtttct ctgcccaaaa tggaaggtga cctcaagggt cctgaagttg    11520

acatcaaggg ccccaaagtg gacattaatg ctccagatgt tgatgttcaa ggcccagact    11580

ggcacctgaa gatgcccaag gtgaaaatgc ccaagttcag catgcctggc ttcaaaggag    11640

agggcccaga tgtggatgtg aacctgccca aggctgacct tgatgtctca ggacccaagg    11700

tggacattga tgttccagat gtgaatatcg aaggcccaga gggaaagttg aaaggtccca    11760

aattcaagat gcctgagatg aacatcaaag cccccaagat ctccatgcct gacattgatc    11820

ttaacctgaa aggacccaaa gtgaagggtg atatggatgt gtctctgcca aaagtggaag    11880

gtgacatgca agttcctgac ttggatatta aaggccccaa agtggatatt aatgccccag    11940

atgtggatgt tcgaggccca gactggcacc tgaagatgcc taagataaaa atgcccaaga    12000

tcagcatgcc tggcttcaaa ggagaaggtc cagaagtgga tgtgaacctg cccaaggctg    12060

accttgacgt ctcaggaccc aaggtggacg ttgatgttcc agatgtgaat attgaaggtc    12120

cagatgcgaa actgaagggc cctaaattca agatgccaga gatgaacatc aaagccccca    12180

agatctccat gcctgacttt gatttgcatc tgaaaggccc taaggtgaaa ggagatgtgg    12240

atgtttctct gcctaagatg gaaggtgatc taaaggcccc tgaagttgac atcaagggcc    12300

ccaaagtgga cattgatgcc ccagatgtgg atgttcatgg cccagactgg cacctgaaga    12360

tgcccaaggt gaaaatgccc aaattcagca tgccaggatt taaaggagag ggcccagaag    12420

tggatgttaa tttgcccaaa gctgacattg atgtctcagg acccaaagtg gacattgaca    12480

ctcctgatat tgatattcat ggtccagaag ggaaactgaa gggccccaaa tttaaaatgc    12540

ctgacctgca cctcaaggca ccgaagatct ctatgcctga agttgacctg aatctgaaag    12600

gtccaaagat gaagggcgac gtggacgttt ctctgcccaa agtggaaggc gacctcaagg    12660

gccctgaagt tgacatcaag ggccccaaag tggacattga tgtcccagat gtggacgttc    12720

aaggcccaga ctggcactta aaaatgccca aagtgaaaat gcccaagttc agcatgcctg    12780

gcttcaaagg agagggccca gatgtggatg tgaacctgcc caaggctgac cttgacgtct    12840

caggacccaa ggtggacatt gatgttcctg atgtgaatat cgaaggtcca gatgcgaaac    12900

taaagggccc taaattcaag atgcctgaga tgaacatcaa agcccccaag atctccatgc    12960

ctgactttga tttgcatctg aaaggtccca aggtgaaggg tgatgtggat gtttcccttc    13020

ctaaagtgga aggtgacctc aagggcccag aagttgacat caagggcccc aaagtggaca    13080

tcgatgcccc tgatgtagat gttcatggcc cagactggca cctgaagatg cccaaggtga    13140

aaatgcccaa attcagcatg ccaggattca aaggagaggg cccagatgtg gatgttaccc    13200

ttcctaaggc tgacattgag atttctggcc ccaaagtgga cattgatgcc cctgatgtca    13260

gtatcgaagg tccagatgca aaactcaagg gtccaaagtt caagatgcca gagatgaaca    13320

tcaaggcccc caaaatctcc atgcctgaca ttgactttaa cttgaagggt cccaaagtga    13380

aaggtgatgt ggatgtctct ctgcccaaag tggaaggtga tctcaagggc cctgaaattg    13440

acataaaagg ccccagtttg gacattgaca cacctgatgt caatattgaa ggtccggaag    13500

gaaaattgaa ggggcccaaa tttaagatgc ctgagatgaa catcaaagct cccaaaatct    13560

ctatgcctga ctttgatttg cacctgaaag gtcccaaggt gaagggtgat gtggatgttt    13620

cactacctaa ggtggaaagt gatctgaaag ggccagaggt agacattgaa ggtcctgaag    13680

ggaagctcaa aggtcccaag tttaagatgc ctgatgtaca tttcaaaagc ccacaaatct    13740

ccatgagtga cattgatttg aatttgaaag gacctaagat aaaaggagat atggacattt    13800

ccgttcctaa actggaggga gatctgaaag gtcccaaagt ggatgtcaaa ggccctaaag    13860

tgggcattga cactcctgat attgacattc atggtccaga agggaaactg aagggcccca    13920

aatttaaaat gcctgactta cacctcaagg caccgaagat ctctatgcct gaagttgacc    13980

tgaatctgaa aggtccaaag gtgaagggcg acatggacat ttctctgccc aaagtggaag    14040

gcgacctcaa gggccccgaa gttgacatca gggaccccaa agtggacatt gatgtcccag    14100

atgtggacgt tcaaggccca gactggcacc taaaaatgcc caaagtgaaa atgcccaagt    14160

tcagcatgcc tggcttcaaa ggagagggcc cagatgtgga tgtgaacctg cccaaggctg    14220

acattgatgt ctcaggaccc aaagtggacg ttgatgttcc tgatgtgaat atcgaaggtc    14280

cagatgcgaa actaaagggc cccaagttca agatgcctga gatgagcatc aaagccccca    14340

agatctccat gcctgatatt gacttaaacc tgaaaggacc caaagtgaag ggcgatgtgg    14400

atgttaccct tcctaaagtg gaaggtgacc tcaagggccc agaagctgac atcaagggcc    14460

caaaagtgga catcaacacc cctgatgtgg atgttcatgg cccagactgg cacctgaaga    14520

tgcccaaggt gaaaatgccc aaattcagca tgcctggctt caaaggagaa ggtccagatg    14580

tggatgtgag cctgcccaag gccgacatcg atgtctcggg acccaaggtg gacgttgata    14640

ttccagatgt gaatatcgaa ggtccagacg caaaactgaa gggccccaag ttcaagatgc    14700

ctgaaataaa tatcaaagct cccaagatct ccatacctga tgttgacctg gatttgaaag    14760

gacccaaagt aaaaggagat tttgatgtgt ctgtccctaa ggttgaaggg actttgaaag    14820

gcccagaagt agatcttaaa ggtccacgtc tggatttcga aggccctgat gccaaactca    14880

gtggcccatc tttgaagatg ccatcgctgg agatatctgc tcctaaagta actgctcctg    14940

atgttgattt gcatctcaag gcaccaaaaa ttggattttc aggtccgaag ttagaaggtg    15000

gtgaagtgga cctcaaggga cccaaagttg aagctccaag cttagatgta cacatggaca    15060

gcccagatat taacatcgaa gggccagatg ttaaaatccc caaatttaag aaacccaagt    15120

ttggatttgg ggcaaaaagc cccaaagctg acatcaagtc accttcactg gatgtcactg    15180

ttcctgaggc agagctgaac cttgagactc ctgaaattag tgttggtggc aagggcaaga    15240

aaagtaagtt taaaatgcct aaaattcata tgagtggtcc taagattaag gccaaaaaac    15300

agggatttga cctgaatgtt cctgggggtg aaattgatgc cagcctcaag gctccggatg    15360

tagatgtcaa catcgcaggg ccggatgctg cactcaaagt cgacgtgaaa tcgcccaaaa    15420

ccaagaaaac gatgtttgga aaaatgtact tcccagatgt agagtttgac attaaatcac    15480

ctaaatttaa agctgaggcc cctctcccta gccccaaact ggagggtgaa ctccaggcac    15540

ctgatctgga actttctttg ccagcgattc acgtcgaagg tcttgacatc aaggcgaagg    15600

ctcccaaggt caagatgcca gatgtggaca tctcagtgcc aaaaatagag ggtgacctga    15660

aaggccccaa agtgcaggca aacttgggtg cacctgacat caacatcgaa ggcctagatg    15720

ctaaagtcaa aacaccgtcc ttcggcattt ctgcccctca agtctccatc cctgatgtga    15780

atgtaaactt gaaaggacca aagataaagg gtgatgtccc cagcgtggga ctggaaggac    15840

cagatgtaga tctgcaaggt ccagaagcaa aaattaagtt ccccaagttt tccatgccca    15900

agatcggcat cccaggtgtg aaaatggagg gtgggggagc cgaggtccat gcccagctac    15960

cctctcttga aggagacttg agaggaccag atgttaagct cgaagggccc gatgtttctc    16020

taaaggggcc aggagtagac ttgccttcag tgaacctctc tatgccaaaa gtctctgggc    16080

ctgaccttga tctgaacttg aaaggaccaa gtttgaaggg agacctggat gcatctgttc    16140

ccagcatgaa ggtgcatgct ccagggctca acctcagtgg tgtcggtggc aaaatgcagg    16200

tgggaggaga cggtgtgaaa gtgccaggga tcgatgccac aacaaagctt aacgttgggg    16260

caccagatgt gacactgagg ggaccaagcc tgcagggaga tctggctgtc tctggtgaca    16320

tcaaatgccc taaagtatcc gtaggagctc ctgatctaag cttggaggca tccgaaggca    16380

gcattaaact tcccaaaatg aagctgcccc aatttggcat ctctactccg gggtccgact    16440

tgcacgtcaa tgccaagggg ccacaggttt ctggcgaact gaaggggcca ggtgtggatg    16500

tgaacctgaa agggcctcgg atttcagcac cgaatgtgga ctttaacttg gaaggaccaa    16560

aagtgaaagg gagccttggg gccactggtg agatcaaagg ccccactgtc ggaggaggtc    16620

ttccaggcat tggtgttcaa ggcctagaag gaaacctcca gatgcctgga attaagtcct    16680

ctggatgtga tgtgaacctg ccaggcgtga atgtgaaact cccaactggg cagatttctg    16740

ggcctgaaat caaaggtggt ctgaaaggtt cagaagtagg tttccatggg gctgctcctg    16800

atatcagtgt gaaggggcct gcctttaata tggcatctcc tgagtcagat tttggcatca    16860

acttgaaggg cccaaaaatc aaaggaggtg cggatgtttc agggggtgtc agtgccccag    16920

acatcagcct tggtgaaggg catttgagtg ttaaaggttc cgggggtgag tggaagggac    16980

cccaagtctc ctctgctctc aacttggaca catctaagtt tgctgggggc cttcatttct    17040

caggaccaaa ggtggaagga ggtgtgaaag gaggtcagat tggactccag gctcctgggc    17100

tgagtgtgtc tgggcctcaa ggtcacttgg aaagtggatc tggaaaagta acattcccta    17160

aaatgaagat ccccaaattt accttctctg gccgtgagct ggttggcaga gaaatggggg    17220

tggatgttca cttccctaaa gcagaggcca gcatccaagc tggtgctgga gacggcgagt    17280

gggaagagtc tgaagtcaaa ctgaaaaagt ccaagatcaa aatgcccaag tttaattttt    17340

ccaaacctaa agggaaaggt ggtgtcactg gctcaccaga agcatcaatt tctgggtcca    17400

aaggtgacct gaaaagttca aaggccagcc tgggctctct ggaaggagag gcagaggccg    17460

aagcctcttc accgaaaggc aaattctcct tatttaaaag taagaagcca cggcaccgct    17520

caaattcatt cagtgatgaa agagagttct ctggaccttc caccccgacg gggacgctgg    17580

agtttgaagg tggggaagtg tctctggaag gtgggaaagt taaagggaaa cacgggaagc    17640

tgaaattcgg tacctttggt ggattggggt caaagagcaa aggtcattat gaggtgactg    17700

ggagcgatga tgagacaggc aagttacagg ggagtggggt gtccctggcc tctaagaagt    17760

cccgactgtc ctcctcttct agcaatgaca gtgggaataa ggttggcatc cagcttcccg    17820

aggtggagct gtcagtttcc acaaagaaag agtagcaggc ctttgtatgt gtgtacatat    17880

atatatatat aacaaaacat cagccttggg tggtgtgttc ctatataaac tccaaaggga    17940

aacacaccga ctgcctcagc aatcatgcaa agaccttgcc tggcccggtg gcaagcgctg    18000

aaaaaccgac cgcctgtagg ctcctggaac tatacagata ggtaaagagt tccaagttcg    18060

tccagcccat gtgcaaagtc aacagtattt gccttaagat ttcatatata tatatttttt    18120

tgcattgact gctgagagct cctgtttact aagcaagctt ttgtgtttat tatcctcatt    18180

tttactgaac attgttagtt ttggggtaat ggaaacccac tttttcattg taatgacttt    18240

gggggctttt gttagtaagg gtgggtgggg tgatgggttg cagacggagg tcaggtcttc    18300

ctctttcctg agactggatc tgttcaaaca gcaaacgccc acagatggcc cagaggtggt    18360

ggtagtcagg gtgtgtgggt gtttttaggg ttctttagtg ttgtttcttt cacccagggg    18420

tggtggtccc agccagtttg gtgctgacgg tgagaggaaa ttagaatctg tttgcaaatt    18480

gtccaaccca ccccctcaac atgaggggct tccattttct gtgttttgta agggaactgt    18540

ttccttcatg ccgccatgtt cctgatatta gttctgattt ctttttaaca aatgttatca    18600

tgattaagaa aatttccagc actttaatgg ccaattaact gagaatgtaa gaaaattgat    18660

gctgtacaag gcaaataaag ctgtttatta accttga                             18697


<210> 122
<211> 5890
<212> PRT
<213> Homo sapiens

<400> 122
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210> 123
<211> 18713
<212> DNA
<213> Homo sapiens

<400> 123
aagctgcgct cgctggaacc ctgcgctcca gcggtgcgcg ccaggagagg gggcccgaag       60

cgaggtctcg cctagagttg gaaaggcagc gtgcttaggg ttgtgaccga gattcccgac      120

gagagagact gaggggaaga gaggaaggag gggcgggctc ctggcaaggc attcgctcct      180

gagcggaatc ctgcaaagat ggagaaggag gagacaaccc gggagctgct gctgcccaac      240

tggcagggta gtggctccca cgggctgacc atcgcccaga gggacgacgg cgtctttgtg      300

caggaggtga cgcagaactc ccctgcggcc cgcactgggg tggtcaagga gggggaccag      360

attgtgggtg ccaccatcta ctttgacaac ctgcagtcgg gtgaggtgac ccagctgctg      420

aacaccatgg ggcaccacac ggtgggcctg aagctgcacc gcaaggggga ccgctctccc      480

gagcctggcc agacctggac ccgtgaagtc ttcagctcct gcagctctga agtggttctg      540

agcggggatg atgaggagta ccagcgcatc tacaccacga agatcaagcc acggctgaag      600

tcggaagatg gagtggaagg agacctcggg gagacccaga gccgtaccat cacagtgacc      660

agaagggtca cggcctacac tgtggatgtg actggccggg aaggagccaa ggacatagac      720

atcagtagcc ctgaattcaa gatcaagatt ccaagacatg aactgactga aatctccaat      780

gtggatgtgg agacccagtc tgggaagacc gtgatcagac tgccctcggg ctcgggggca      840

gcctctccga caggctctgc tgtggatatc cgagcagggg ccatttctgc ttcaggacca      900

gagctccaag gtgctggcca ctcgaagctc caggtcacca tgcctgggat aaaggtggga      960

ggctcaggtg tcaatgtcaa tgcaaagggc ttggacttgg gtggcagagg aggggtccaa     1020

gttccagcag tggacatttc atcttctctt gggggtaggg cagtagaggt acagggccca     1080

tctctggaga gtggtgatca tggcaaaatt aaatttccca ccatgaaagt gccgaaattt     1140

ggtgtctcaa cagggcgtga gggccagaca ccaaaggcag ggctgagggt ttctgcacct     1200

gaagtctctg tggggcacaa gggcggcaag ccaggcttga ctatccaagc ccctcagctg     1260

gaagtcagtg tgccctctgc caatattgag ggccttgagg ggaagctgaa gggcccccaa     1320

atcactgggc catcacttga gggtgaccta ggcctgaaag gtgccaagcc acaggggcac     1380

attggggtgg atgcctctgc tccccaaatt gggggtagca tcactggccc cagtgtggaa     1440

gttcaggccc ctgacattga tgttcagggg cctgggagca aactgaatgt gcccaagatg     1500

aaagtcccca agttctctgt atcaggtgca aagggagagg aaactgggat tgatgtgaca     1560

ctgcctacag gtgaagtgac tgttcctggg gtctctgggg atgtcagcct gcctgagatt     1620

gctactggtg ggctggaagg aaagatgaaa ggtactaaag tgaagactcc tgaaatgatt     1680

attcagaaac ctaaaatctc catgcaggat gtggatctga gccttgggtc tcctaaactg     1740

aaaggagata ttaaggtttc tgctcctggg gtgcaaggtg atgttaaagg ccctcaagtg     1800

gcacttaaag gctccagagt ggacatagag acaccaaacc tagagggaac cttgacaggc     1860

cctaggcttg gcagtccttc cgggaaaacc ggaacctgta ggatctctat gtcagaagta     1920

gacttaaatg tggccgcacc taaagtgaaa gggggtgtag atgtcacact ccccagagta     1980

gaagggaaag tcaaagtccc tgaagttgat gtcagaggcc ccaaagtgga tgtcagtgcc     2040

ccagatgtcg aagcgcatgg cccagaatgg aacctgaaaa tgcccaagat gaaaatgccc     2100

acgttcagca ctccaggagc caaaggggaa ggtccagatg ttcatatgac tctacccaaa     2160

ggagatatca gtatttcagg gcccaaggtc aatgtggaag ccccagatgt caacttggag     2220

ggtctggggg gaaaacttaa aggccccgat gttaagctgc ctgatatgag tgtcaagaca     2280

ccaaagatct ccatgcctga tgtagatttg cacgtgaaag gtacaaaggt gaagggagag     2340

tatgatgtaa ctgtaccaaa gctggaagga gaactcaaag gcccaaaagt ggacattgat     2400

gccccagatg tggatgttca tggcccagac tggcacttga agatgcccaa gatgaaaatg     2460

cccaaattca gtgtgccagg gttcaaagca gagggcccag aagtggatgt gaacctgccc     2520

aaggctgatg tggacatttc cgggcccaag atagatgtta ctgctcctga tgtgagcatt     2580

gaggaaccag aagggaaatt gaaagggccc aagtttaaga tgcctgagat gaacatcaaa     2640

gtccccaaga tctccatgcc tgatgtggac ttacatctga aaggccctaa cgtaaaggga     2700

gaatatgatg tcacaatgcc aaaggttgaa agtgagatta aagttcctga tgttgaactt     2760

aaaagtgcca aaatggacat tgatgtccca gatgtggagg ttcaaggccc agactggcac     2820

ctgaagatgc ccaagatgaa aatgcccaag ttcagcatgc ctggcttcaa agcagagggc     2880

ccagaagtgg atgtgaacct gcccaaggct gatgtggaca tctcaggacc caaggtgggt     2940

gttgaagttc cagatgtgaa tattgaagga cctgaaggaa agctgaaggg ccccaagttc     3000

aagatgccag agatgaatat caaggccccc aagatctcca tgcctgatgt ggacttgcat     3060

atgaaaggtc ctaaagtaaa gggagaatat gatatgacag tgccaaagct ggaaggggac     3120

ctgaaaggcc caaaagtaga tgtcagtgcc ccagatgttg aaatgcaggg tcctgactgg     3180

aacttgaaga tgccaaagat taaaatgccc aaatttagca tgcccagcct caaaggagag     3240

gggccagaat ttgatgtgaa cctgtccaaa gcgaatgtgg acatttctgc accaaaagta     3300

gatactaatg ctccagatct gagccttgaa ggacctgaag ggaagttgaa aggcccgaag     3360

tttaagatgc ctgagatgca cttcagagct cctaagatgt ctttgccaga tgttgacctg     3420

gatcttaaag gacccaaaat gaaaggaaat gtagatatct ctgcaccaaa gatagagggt     3480

gaaatgcagg ttccagatgt ggacatcaga ggtcccaagg tagatattaa agcaccagat     3540

gtggaaggcc aaggcctgga ctggagcctg aaaataccca agatgaaaat gcccaagttc     3600

agcatgccca gcctcaaagg cgagggccca gaagtggatg tgaacttgcc taaggctgac     3660

gttgttgtct caggacccaa ggtggacatc gaagccccag atgtgagcct cgaaggtcca     3720

gaagggaagc tgaagggtcc caagtttaag atgcctgaga tgcatttcaa gacccccaag     3780

atctccatgc ctgatgtgga cttacacttg aaaggcccca aagtcaaagg ggatgtggat     3840

gtgtctgtgc ccaaggtaga aggtgaaatg aaagtgccag atgttgaaat caaaggaccc     3900

aaaatggaca ttgatgcccc agatgtggag gttcaaggcc cagactggca cctgaagatg     3960

cccaagatga aaatgcccaa gtttagcatg cctggcttca aaggagaggg ccgagaagtg     4020

gatgtgaacc tgcccaaggc tgacattgat gtctcaggac ccaaggtgga tgttgaagtc     4080

ccagatgtga gccttgaggg cccggaagga aagctgaagg gccccaagtt taagatgcct     4140

gagatgcact tcaaggcccc caagatctcc atgcctgatg tggacctgaa tcttaagggg     4200

ccaaaattga agggagatgt ggatgtgtcc ttgcctgagg tagaaggtga aatgaaagtg     4260

ccagatgttg acattaaagg gcccaaagtt gacattagtg ctccagatgt ggatgttcat     4320

ggcccagatt ggcacctgaa gatgcccaag gtgaaaatgc ccaagttcag catgcccggc     4380

ttcaaaggag agggccctga agtggatgtg aagctgccca aagctgacgt tgatgtctca     4440

ggacccaaaa tggatgctga agttccagat gtgaatattg aaggtccaga cgcaaaacta     4500

aaaggtccca aattcaagat gccagaaatg agtataaagc ctcagaagat atccatacca     4560

gatgttggtt tgcatttgaa aggtcctaaa atgaaaggag attatgatgt aacagttcca     4620

aaagtagaag gagagataaa agctcctgat gttgacatca aaggccccaa agttgatatt     4680

aatgcaccag atgtggaggt tcatggccca gactggcacc tgaagatgcc caaggtaaaa     4740

atgcccaagt tcagcatgcc tggctttaaa ggagagggcc cagaggtgga tatgaacctg     4800

cccaaggctg accttggtgt ttcaggaccc aaggtggaca ttgatgttcc agatgtgaat     4860

cttgaagctc cagaggggaa actaaaaggc cctaagttca agatgccaag catgaatata     4920

cagacgcaca aaatctctat gcctgatgtt ggacttaatt tgaaagcccc taaactgaaa     4980

actgatgtag atgtttccct tcccaaagtg gaaggagact tgaagggtcc tgaaattgat     5040

gtgaaagccc ctaagatgga tgtgaatgtt ggtgatattg atattgaagg tccagaaggg     5100

aagttgaagg gccccaagtt taagatgcct gagatgcatt tcaaggcccc caagatctcc     5160

atgcccgatg tggacttaca cttgaaaggc cccaaagtca aaggggatat ggatgtgtct     5220

gtgcccaagg tagaaggtga aatgaaagtg ccagatgttg acattaaagg gcccaaagtg     5280

gacattgatg ccccagatgt ggaggttcac gacccagatt ggcacctgaa aatgcccaag     5340

atgaaaatgc ccaagttcag tatgcctggc ttcaaagcag agggccctga agtggatgtg     5400

aatctgccaa aggctgacat tgatgtgtct ggacccagtg tggacactga tgctcctgat     5460

ttggatattg agggaccaga aggaaagttg aaaggctcca aatttaagat gcccaagttg     5520

aatataaaag ctcccaaggt ctccatgcca gatgtggact tgaatttgaa gggacccaaa     5580

ctgaagggag agatagatgc ttctgtgcca gaactggaag gtgatctcag agggccgcaa     5640

gttgatgtca aaggtccttt tgtggaagcg gaggtgcccg atgttgatct ggagtgtcct     5700

gatgcaaagt tgaaagggcc caagtttaag atgcctgaga tgcacttcaa ggcccccaag     5760

atctccatgc ctgatgtgga cttacacctg aaaggcccca aagtcaaagg ggatgcggat     5820

gtgtcggtgc caaaattgga gggagattta acaggcccca gtgtgggtgt ggaggtgcct     5880

gatgttgagc tggagtgtcc tgatgcaaag ttgaaaggcc ctaaatttaa gatgccagac     5940

atgcacttca aggcccccaa gatctccatg cctgatgtgg acttacactt gaaaggcccc     6000

aaagtcaaag gggatgtgga tgtgtcggtg ccaaaattgg agggagattt aacaggtccc     6060

agtgtgggtg tggaggtgcc tgatgttgag ctggagtgtc ctgatgcaaa gttgaaaggg     6120

cccaagttta agatgcctga gatgcacttc aagaccccca agatctccat gcctgatgtg     6180

gacttacacc tgaaaggccc caaagtcaaa ggggatatgg atgtgtctgt gcccaaggta     6240

gaaggtgaaa tgaaagtgcc agatgttgac atcaaaggac ccaaaatgga cattgatgcc     6300

ccagatgtgg atgttcatgg cccagactgg cacctgaaga tgcccaagat gaaaatgccc     6360

aagttcagca tgcctggctt caaagcagag ggcccagaag tggatgtgaa cttgcccaag     6420

gctgatgttg ttgtctcagg acccaaggtg gatgttgaag tcccagatgt gagccttgaa     6480

ggtccagaag ggaagctgaa gggccccaag cttaagatgc ctgagatgca cttcaaggcc     6540

cccaagatct ccatgcctga tgtggactta cacttgaaag gccccaaagt caaaggggat     6600

gtggatgtgt ctttgccaaa attggaggga gatttaacag gccccagtgt ggatgtggag     6660

gtgcctgatg ttgagctgga gtgtcctgat gcaaagttga aagggcccaa gtttaagatg     6720

cctgagatgc acttcaagac ccccaagatc tccatgcctg atgtgaactt aaacttgaaa     6780

ggccccaaag tcaaagggga tatggatgtg tctgttccca aggtagaagg tgaaatgaaa     6840

gtgccagatg ttgacatcag agggcccaaa gtggacattg atgccccaga tgtggatgtt     6900

catggcccag actggcacct gaagatgcct aagatgaaaa tgcccaagtt cagcatgcct     6960

ggcttcaaag gagagggccc agaagtggat gtgaacttgc ccaaggctga cgttgatgtc     7020

tcaggaccca aggtggatgt tgaagtccca gatgtgagcc ttgaaggtcc agaagggaag     7080

ctgaagggcc ccaagtttaa gatgcctgag atgcacttca agacccccaa gatctccatg     7140

cctgatgttg atttcaattt aaagggaccc aaaatcaaag gagatgttga tgtttctgcc     7200

ccaaagctgg agggagagtt aaaaggtcca gaattggatg tcaaaggtcc caaattagat     7260

gctgacatgc cagaagtagc tgtggaaggc ccaaatggca agtggaaaac tcctaagttc     7320

aagatgccag atatgcactt taaagctccc aaaatctcta tgccagacct cgatctacac     7380

ttgaagagcc ccaaggcaaa aggagaggtg gatgtagatg ttcccaaatt ggaaggggac     7440

cttaaagggc cacatgtgga tgtcagtggg ccagacattg acattgaggg accagagggc     7500

aaattgaaag gccctaagtt caagatgcct gatatgcatt tcaaagcccc caatatttct     7560

atgcctgatg ttgatctaaa tctcaaagga cccaaaatca agggggatgt ggatgtgtct     7620

gtgcctgagg tagaaggtaa acttgaagta ccagatatga acatcagggg ccccaaagtt     7680

gatgtaaatg cccccgatgt ccaagctcca gactggcacc tgaagatgcc caagatgaaa     7740

atgcccaagt tcagcatgcc tggcttcaaa gcagagggcc ctgaagtaga cgtcaacttg     7800

cctaaggctg acgttgacat ctcaggaccc aaggtggaca ttgaaggccc tgatgttaat     7860

attgaaggac cagagggaaa gttgaaaggg cctaagttaa agatgccaga gatgaacatc     7920

aaagccccca agatctccat gcctgacttt gatttgcatc tgaaaggtcc caaggtgaag     7980

ggcgatgtgg atgtttctct gcccaaagtg gaaggtgacc tcaagggccc cgaagttgac     8040

atcaaggggc ccaaagtgga tattaatgcc ccagatgtgg gtgttcaagg cccagactgg     8100

cacctgaaga tgcccaaggt gaaaatgcca aagttcagca tgcctggctt caaaggagag     8160

ggcccagatg gggatgtgaa gctgcccaag gctgacattg atgtctcagg acccaaagtg     8220

gacattgaag gccctgatgt taacattgaa ggaccagagg gaaagttgaa agggcctaag     8280

ttcaagatgc cagagatgaa tatcaaagcc cccaagatct ccatgcctga tattgactta     8340

aacctgaaag gacccaaagt gaagggtgat gtggatgttt cccttcctaa agtggaaggt     8400

gacctcaagg gcccagaagt tgacatcaag ggcccaaaag tggacattga cgcacctgat     8460

gttgatgttc atggcccaga ctggcaccta aagatgccca agataaaaat gcccaagatc     8520

agcatgcctg gcttcaaagg agaaggtcca gatgtggacg tgaacctgcc caaggctgac     8580

attgatgtct caggaccgaa agtggatgtt gaatgtcccg atgtgaatat cgaaggacct     8640

gaaggaaagt ggaaaagtcc aaagtttaag atgccagaga tgcattttaa gactccaaag     8700

atatccatgc cagatattga cctgaatctc acaggtccaa aaataaaagg agatgtggat     8760

gttacaggcc ctaaggtaga gggagatctg aaaggtcctg aagttgacct caaaggcccc     8820

aaagtggaca ttgatgtccc agatgttaat gttcagggtc cagactggca cctgaagatg     8880

cccaagatga aaatgcccaa gttcagcatg cctggcttca aagcagaggg ccctgaagtg     8940

gatgtgaacc tgcccaaggc tgacgttgat gtctcaggcc ccaaagtgga cgttgaaggc     9000

cctgatgtta acattgaagg accagaggga aagttgaaag ggcccaagtt caagatgcca     9060

gagatgaata tcaaagcccc caagatcccc atgcctgact ttgatttgca tctgaaaggt     9120

cccaaggtga agggcgatgt ggatatttct ctgcccaaag tggaaggtga cctcaagggc     9180

cctgaagttg acatcagggg tccccaagtg gacattgatg tcccggatgt gggcgttcaa     9240

ggcccagact ggcacctaaa aatgcccaaa gtgaaaatgc ccaaattcag catgcctggc     9300

ttcaaaggag agggcccaga tgtggatgtg aacctgccca aggctgacct tgatgtctca     9360

ggacccaagg tggacattga tgttccagat gtgaatatcg aaggcccaga gggaaagttg     9420

aaaggtccca aattcaaaat gcctgagatg aacatcaaag cccccaagat ctccatgcct     9480

gacattgatc ttaacctgaa aggtcccaaa gtgaagggtg acatggatgt gtctctgcca     9540

aaagtggaag gtgacatgaa agttcctgac gtggatatta aaggccccaa agtggatatt     9600

aatgccccag atgtggatgt tcaaggccca gactggcacc tgaagatgcc taaaataaaa     9660

atgcccaaga tcagcatgcc tggcttcaaa ggagaaggtc cagaagtgga cgtgaacctg     9720

cccaaggctg accttgacgt ctcaggaccc aaggtggacg ttgatgttcc agatgtgaat     9780

attgaaggtc cagatgcgaa actgaagggc cctaaattca agatgccaga gatgaacatc     9840

aaagctccta aaatatcaat gcctgatttg gacctcaatc ttaaaggccc taaaatgaaa     9900

ggagaggtgg atgtttcact tgcaaatgta gaaggtgatt tgaaaggacc tgctcttgac     9960

ataaaaggcc caaagataga tgtagatgct ccagatattg acattcatgg cccagatgcc    10020

aaattaaaag gtccaaaact gaagatgcct gacatgcatg taaacatgcc caagatctcc    10080

atgccagaaa ttgacttgaa tttgaaaggc tcaaagctta agggagatgt tgatgtctct    10140

gggcccaagt tggaaggtga cattaaagct cccagtttgg atataaaggg cccagaagtg    10200

gacgtttccg gtcctaagct taatatcgaa ggcaagtcaa agaaatctcg ttttaagctt    10260

cccaaattta atttttcggg ctctaaagtt cagacacctg aagtggatgt caaaggtaaa    10320

aagccagata ttgacataac aggtccaaaa gttgatatta atgctcctga tgtcgaggtc    10380

caaggaaaag tgaaaggatc caagtttaaa atgcctttcc tgagtatttc atctcccaaa    10440

gtttctatgc ctgacgtgga gctaaatttg aaaagtccca aagtcaaagg agacttagat    10500

attgcaggtc ccaatttaga aggtgacttt aaaggcccca aagtggatat taaggcacca    10560

gaagtcaatc ttaatgcacc tgatgtggat gttcatggtc cagactggaa tctgaaaatg    10620

cccaagatga aaatgcccaa attcagtgtg tctggcttaa aagcagaagg gccagatgta    10680

gctgtggatc taccaaaagg agacatcaac atagagggcc caagtatgaa cattgagggc    10740

ccagatctca atgtggaagg tccggaggga ggcttgaaag gtcccaaatt caagatgcct    10800

gacatgaata tcaaagctcc caagatctcc atgcctgaca ttgacttaaa cttgaaaggc    10860

cccaaggtga aaggtgatgt ggatatttct cttcccaaac ttgaagggga tctgaaaggg    10920

ccagaggttg atatcaaagg ccctaaagtg gacatcaatg ccccagatgt ggatgttcat    10980

ggtccagact ggcatctgaa gatgcccaaa gtgaaaatgc ccaagttcag catgcctggc    11040

ttcaaaggag aaggccctga agtcgatgtt accctcccta aagctgacat tgacatttct    11100

ggtcccaatg tagacgttga tgttccagac gtgaatattg aaggtccaga tgcaaagctg    11160

aagggcccca agttcaagat gcctgagatg aacatcaaag cccccaagat ctccatgcct    11220

gactttgacc tgaacttgaa gggacccaaa atgaagggtg atgtggttgt gtctttgccc    11280

aaagtggaag gtgatctaaa aggccctgag gtggacatca agggccccaa agtggacatt    11340

gacactcctg acattaacat cgaaggctca gagggtaaat tcaagggacc caaatttaag    11400

ataccagaga tgcacctgaa ggctcccaaa atatcgatgc ctgacattga tttaaacctg    11460

aagggcccca aagtcaaggg cgatgtggat gtttctctgc ccaaaatgga aggtgacctc    11520

aagggtcctg aagttgacat caagggcccc aaagtggaca ttaatgctcc agatgttgat    11580

gttcaaggcc cagactggca cctgaagatg cccaaggtga aaatgcccaa gttcagcatg    11640

cctggcttca aaggagaggg cccagatgtg gatgtgaacc tgcccaaggc tgaccttgat    11700

gtctcaggac ccaaggtgga cattgatgtt ccagatgtga atatcgaagg cccagaggga    11760

aagttgaaag gtcccaaatt caagatgcct gagatgaaca tcaaagcccc caagatctcc    11820

atgcctgaca ttgatcttaa cctgaaagga cccaaagtga agggtgatat ggatgtgtct    11880

ctgccaaaag tggaaggtga catgcaagtt cctgacttgg atattaaagg ccccaaagtg    11940

gatattaatg ccccagatgt ggatgttcga ggcccagact ggcacctgaa gatgcctaag    12000

ataaaaatgc ccaagatcag catgcctggc ttcaaaggag aaggtccaga agtggatgtg    12060

aacctgccca aggctgacct tgacgtctca ggacccaagg tggacgttga tgttccagat    12120

gtgaatattg aaggtccaga tgcgaaactg aagggcccta aattcaagat gccagagatg    12180

aacatcaaag cccccaagat ctccatgcct gactttgatt tgcatctgaa aggccctaag    12240

gtgaaaggag atgtggatgt ttctctgcct aagatggaag gtgatctaaa ggcccctgaa    12300

gttgacatca agggccccaa agtggacatt gatgccccag atgtggatgt tcatggccca    12360

gactggcacc tgaagatgcc caaggtgaaa atgcccaaat tcagcatgcc aggatttaaa    12420

ggagagggcc cagaagtgga tgttaatttg cccaaagctg acattgatgt ctcaggaccc    12480

aaagtggaca ttgacactcc tgatattgat attcatggtc cagaagggaa actgaagggc    12540

cccaaattta aaatgcctga cctgcacctc aaggcaccga agatctctat gcctgaagtt    12600

gacctgaatc tgaaaggtcc aaagatgaag ggcgacgtgg acgtttctct gcccaaagtg    12660

gaaggcgacc tcaagggccc tgaagttgac atcaagggcc ccaaagtgga cattgatgtc    12720

ccagatgtgg acgttcaagg cccagactgg cacttaaaaa tgcccaaagt gaaaatgccc    12780

aagttcagca tgcctggctt caaaggagag ggcccagatg tggatgtgaa cctgcccaag    12840

gctgaccttg acgtctcagg acccaaggtg gacattgatg ttcctgatgt gaatatcgaa    12900

ggtccagatg cgaaactaaa gggccctaaa ttcaagatgc ctgagatgaa catcaaagcc    12960

cccaagatct ccatgcctga ctttgatttg catctgaaag gtcccaaggt gaagggtgat    13020

gtggatgttt cccttcctaa agtggaaggt gacctcaagg gcccagaagt tgacatcaag    13080

ggccccaaag tggacatcga tgcccctgat gtagatgttc atggcccaga ctggcacctg    13140

aagatgccca aggtgaaaat gcccaaattc agcatgccag gattcaaagg agagggccca    13200

gatgtggatg ttacccttcc taaggctgac attgagattt ctggccccaa agtggacatt    13260

gatgcccctg atgtcagtat cgaaggtcca gatgcaaaac tcaagggtcc aaagttcaag    13320

atgccagaga tgaacatcaa ggcccccaaa atctccatgc ctgacattga ctttaacttg    13380

aagggtccca aagtgaaagg tgatgtggat gtctctctgc ccaaagtgga aggtgatctc    13440

aagggccctg aaattgacat aaaaggcccc agtttggaca ttgacacacc tgatgtcaat    13500

attgaaggtc cggaaggaaa attgaagggg cccaaattta agatgcctga gatgaacatc    13560

aaagctccca aaatctctat gcctgacttt gatttgcacc tgaaaggtcc caaggtgaag    13620

ggtgatgtgg atgtttcact acctaaggtg gaaagtgatc tgaaagggcc agaggtagac    13680

attgaaggtc ctgaagggaa gctcaaaggt cccaagttta agatgcctga tgtacatttc    13740

aaaagcccac aaatctccat gagtgacatt gatttgaatt tgaaaggacc taagataaaa    13800

ggagatatgg acatttccgt tcctaaactg gagggagatc tgaaaggtcc caaagtggat    13860

gtcaaaggcc ctaaagtggg cattgacact cctgatattg acattcatgg tccagaaggg    13920

aaactgaagg gccccaaatt taaaatgcct gacttacacc tcaaggcacc gaagatctct    13980

atgcctgaag ttgacctgaa tctgaaaggt ccaaaggtga agggcgacat ggacatttct    14040

ctgcccaaag tggaaggcga cctcaagggc cccgaagttg acatcaggga ccccaaagtg    14100

gacattgatg tcccagatgt ggacgttcaa ggcccagact ggcacctaaa aatgcccaaa    14160

gtgaaaatgc ccaagttcag catgcctggc ttcaaaggag agggcccaga tgtggatgtg    14220

aacctgccca aggctgacat tgatgtctca ggacccaaag tggacgttga tgttcctgat    14280

gtgaatatcg aaggtccaga tgcgaaacta aagggcccca agttcaagat gcctgagatg    14340

agcatcaaag cccccaagat ctccatgcct gatattgact taaacctgaa aggacccaaa    14400

gtgaagggcg atgtggatgt tacccttcct aaagtggaag gtgacctcaa gggcccagaa    14460

gctgacatca agggcccaaa agtggacatc aacacccctg atgtggatgt tcatggccca    14520

gactggcacc tgaagatgcc caaggtgaaa atgcccaaat tcagcatgcc tggcttcaaa    14580

ggagaaggtc cagatgtgga tgtgagcctg cccaaggccg acatcgatgt ctcgggaccc    14640

aaggtggacg ttgatattcc agatgtgaat atcgaaggtc cagacgcaaa actgaagggc    14700

cccaagttca agatgcctga aataaatatc aaagctccca agatctccat acctgatgtt    14760

gacctggatt tgaaaggacc caaagtaaaa ggagattttg atgtgtctgt ccctaaggtt    14820

gaagggactt tgaaaggccc agaagtagat cttaaaggtc cacgtctgga tttcgaaggc    14880

cctgatgcca aactcagtgg cccatctttg aagatgccat cgctggagat atctgctcct    14940

aaagtaactg ctcctgatgt tgatttgcat ctcaaggcac caaaaattgg attttcaggt    15000

ccgaagttag aaggtggtga agtggacctc aagggaccca aagttgaagc tccaagctta    15060

gatgtacaca tggacagccc agatattaac atcgaagggc cagatgttaa aatccccaaa    15120

tttaagaaac ccaagtttgg atttggggca aaaagcccca aagctgacat caagtcacct    15180

tcactggatg tcactgttcc tgaggcagag ctgaaccttg agactcctga aattagtgtt    15240

ggtggcaagg gcaagaaaag taagtttaaa atgcctaaaa ttcatatgag tggtcctaag    15300

attaaggcca aaaaacaggg atttgacctg aatgttcctg ggggtgaaat tgatgccagc    15360

ctcaaggctc cggatgtaga tgtcaacatc gcagggccgg atgctgcact caaagtcgac    15420

gtgaaatcgc ccaaaaccaa gaaaacgatg tttggaaaaa tgtacttccc agatgtagag    15480

tttgacatta aatcacctaa atttaaagct gaggcccctc tccctagccc caaactggag    15540

ggtgaactcc aggcacctga tctggaactt tctttgccag cgattcacgt cgaaggtctt    15600

gacatcaagg cgaaggctcc caaggtcaag atgccagatg tggacatctc agtgccaaaa    15660

atagagggtg acctgaaagg ccccaaagtg caggcaaact tgggtgcacc tgacatcaac    15720

atcgaaggcc tagatgctaa agtcaaaaca ccgtccttcg gcatttctgc ccctcaagtc    15780

tccatccctg atgtgaatgt aaacttgaaa ggaccaaaga taaagggtga tgtccccagc    15840

gtgggactgg aaggaccaga tgtagatctg caaggtccag aagcaaaaat taagttcccc    15900

aagttttcca tgcccaagat cggcatccca ggtgtgaaaa tggagggtgg gggagccgag    15960

gtccatgccc agctaccctc tcttgaagga gacttgagag gaccagatgt taagctcgaa    16020

gggcccgatg tttctctaaa ggggccagga gtagacttgc cttcagtgaa cctctctatg    16080

ccaaaagtct ctgggcctga ccttgatctg aacttgaaag gaccaagttt gaagggagac    16140

ctggatgcat ctgttcccag catgaaggtg catgctccag ggctcaacct cagtggtgtc    16200

ggtggcaaaa tgcaggtggg aggagacggt gtgaaagtgc cagggatcga tgccacaaca    16260

aagcttaacg ttggggcacc agatgtgaca ctgaggggac caagcctgca gggagatctg    16320

gctgtctctg gtgacatcaa atgccctaaa gtatccgtag gagctcctga tctaagcttg    16380

gaggcatccg aaggcagcat taaacttccc aaaatgaagc tgccccaatt tggcatctct    16440

actccggggt ccgacttgca cgtcaatgcc aaggggccac aggtttctgg cgaactgaag    16500

gggccaggtg tggatgtgaa cctgaaaggg cctcggattt cagcaccgaa tgtggacttt    16560

aacttggaag gaccaaaagt gaaagggagc cttggggcca ctggtgagat caaaggcccc    16620

actgtcggag gaggtcttcc aggcattggt gttcaaggcc tagaaggaaa cctccagatg    16680

cctggaatta agtcctctgg atgtgatgtg aacctgccag gcgtgaatgt gaaactccca    16740

actgggcaga tttctgggcc tgaaatcaaa ggtggtctga aaggttcaga agtaggtttc    16800

catggggctg ctcctgatat cagtgtgaag gggcctgcct ttaatatggc atctcctgag    16860

tcagattttg gcatcaactt gaagggccca aaaatcaaag gaggtgcgga tgtttcaggg    16920

ggtgtcagtg ccccagacat cagccttggt gaagggcatt tgagtgttaa aggttccggg    16980

ggtgagtgga agggacccca agtctcctct gctctcaact tggacacatc taagtttgct    17040

gggggccttc atttctcagg accaaaggtg gaaggaggtg tgaaaggagg tcagattgga    17100

ctccaggctc ctgggctgag tgtgtctggg cctcaaggtc acttggaaag tggatctgga    17160

aaagtaacat tccctaaaat gaagatcccc aaatttacct tctctggccg tgagctggtt    17220

ggcagagaaa tgggggtgga tgttcacttc cctaaagcag aggccagcat ccaagctggt    17280

gctggagacg gcgagtggga agagtctgaa gtcaaactga aaaagtccaa gatcaaaatg    17340

cccaagttta atttttccaa acctaaaggg aaaggtggtg tcactggctc accagaagca    17400

tcaatttctg ggtccaaagg tgacctgaaa agttcaaagg ccagcctggg ctctctggaa    17460

ggagaggcag aggccgaagc ctcttcaccg aaaggcaaat tctccttatt taaaagtaag    17520

aagccacggc accgctcaaa ttcattcagt gatgaaagag agttctctgg accttccacc    17580

ccgacgggga cgctggagtt tgaaggtggg gaagtgtctc tggaaggtgg gaaagttaaa    17640

gggaaacacg ggaagctgaa attcggtacc tttggtggat tggggtcaaa gagcaaaggt    17700

cattatgagg tgactgggag cgatgatgag acaggcaagt tacaggggag tggggtgtcc    17760

ctggcctcta agaagtcccg actgtcctcc tcttctagca atgacagtgg gaataaggtt    17820

ggcatccagc ttcccgaggt ggagctgtca gtttccacaa agaaagagta gcaggccttt    17880

gtatgtgtgt acatatatat atatataaca aaacatcagc cttgggtggt gtgttcctat    17940

ataaactcca aagggaaaca caccgactgc ctcagcaatc atgcaaagac cttgcctggc    18000

ccggtggcaa gcgctgaaaa accgaccgcc tgtaggctcc tggaactata cagataggta    18060

aagagttcca agttcgtcca gcccatgtgc aaagtcaaca gtatttgcct taagatttca    18120

tatatatata tttttttgca ttgactgctg agagctcctg tttactaagc aagcttttgt    18180

gtttattatc ctcattttta ctgaacattg ttagttttgg ggtaatggaa acccactttt    18240

tcattgtaat gactttgggg gcttttgtta gtaagggtgg gtggggtgat gggttgcaga    18300

cggaggtcag gtcttcctct ttcctgagac tggatctgtt caaacagcaa acgcccacag    18360

atggcccaga ggtggtggta gtcagggtgt gtgggtgttt ttagggttct ttagtgttgt    18420

ttctttcacc caggggtggt ggtcccagcc agtttggtgc tgacggtgag aggaaattag    18480

aatctgtttg caaattgtcc aacccacccc ctcaacatga ggggcttcca ttttctgtgt    18540

tttgtaaggg aactgtttcc ttcatgccgc catgttcctg atattagttc tgatttcttt    18600

ttaacaaatg ttatcatgat taagaaaatt tccagcactt taatggccaa ttaactgaga    18660

atgtaagaaa attgatgctg tacaaggcaa ataaagctgt ttattaacct tga           18713


<210> 124
<211> 5890
<212> PRT
<213> Homo sapiens

<400> 124
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210> 125
<211> 18761
<212> DNA
<213> Homo sapiens

<400> 125
ggccactcgg agctgctctg ccgcggggac tgcaccgccc gccctgccag acccgcccgg       60

aacggggctc gtcgccgcca gtagccgcag caccgcagcc ttgggcctcg cgccggctat      120

ggccgtgccc tggggctgag ccctcaggtt gtgaccgaga ttcccgacga gagagactga      180

ggggaagaga ggaaggaggg gcgggctcct ggcaaggcat tcgctcctga gcggaatcct      240

gcaaagatgg agaaggagga gacaacccgg gagctgctgc tgcccaactg gcagggtagt      300

ggctcccacg ggctgaccat cgcccagagg gacgacggcg tctttgtgca ggaggtgacg      360

cagaactccc ctgcggcccg cactggggtg gtcaaggagg gggaccagat tgtgggtgcc      420

accatctact ttgacaacct gcagtcgggt gaggtgaccc agctgctgaa caccatgggg      480

caccacacgg tgggcctgaa gctgcaccgc aagggggacc gctctcccga gcctggccag      540

acctggaccc gtgaagtctt cagctcctgc agctctgaag tggttctgag cggggatgat      600

gaggagtacc agcgcatcta caccacgaag atcaagccac ggctgaagtc ggaagatgga      660

gtggaaggag acctcgggga gacccagagc cgtaccatca cagtgaccag aagggtcacg      720

gcctacactg tggatgtgac tggccgggaa ggagccaagg acatagacat cagtagccct      780

gaattcaaga tcaagattcc aagacatgaa ctgactgaaa tctccaatgt ggatgtggag      840

acccagtctg ggaagaccgt gatcagactg ccctcgggct cgggggcagc ctctccgaca      900

ggctctgctg tggatatccg agcaggggcc atttctgctt caggaccaga gctccaaggt      960

gctggccact cgaagctcca ggtcaccatg cctgggataa aggtgggagg ctcaggtgtc     1020

aatgtcaatg caaagggctt ggacttgggt ggcagaggag gggtccaagt tccagcagtg     1080

gacatttcat cttctcttgg gggtagggca gtagaggtac agggcccatc tctggagagt     1140

ggtgatcatg gcaaaattaa atttcccacc atgaaagtgc cgaaatttgg tgtctcaaca     1200

gggcgtgagg gccagacacc aaaggcaggg ctgagggttt ctgcacctga agtctctgtg     1260

gggcacaagg gcggcaagcc aggcttgact atccaagccc ctcagctgga agtcagtgtg     1320

ccctctgcca atattgaggg ccttgagggg aagctgaagg gcccccaaat cactgggcca     1380

tcacttgagg gtgacctagg cctgaaaggt gccaagccac aggggcacat tggggtggat     1440

gcctctgctc cccaaattgg gggtagcatc actggcccca gtgtggaagt tcaggcccct     1500

gacattgatg ttcaggggcc tgggagcaaa ctgaatgtgc ccaagatgaa agtccccaag     1560

ttctctgtat caggtgcaaa gggagaggaa actgggattg atgtgacact gcctacaggt     1620

gaagtgactg ttcctggggt ctctggggat gtcagcctgc ctgagattgc tactggtggg     1680

ctggaaggaa agatgaaagg tactaaagtg aagactcctg aaatgattat tcagaaacct     1740

aaaatctcca tgcaggatgt ggatctgagc cttgggtctc ctaaactgaa aggagatatt     1800

aaggtttctg ctcctggggt gcaaggtgat gttaaaggcc ctcaagtggc acttaaaggc     1860

tccagagtgg acatagagac accaaaccta gagggaacct tgacaggccc taggcttggc     1920

agtccttccg ggaaaaccgg aacctgtagg atctctatgt cagaagtaga cttaaatgtg     1980

gccgcaccta aagtgaaagg gggtgtagat gtcacactcc ccagagtaga agggaaagtc     2040

aaagtccctg aagttgatgt cagaggcccc aaagtggatg tcagtgcccc agatgtcgaa     2100

gcgcatggcc cagaatggaa cctgaaaatg cccaagatga aaatgcccac gttcagcact     2160

ccaggagcca aaggggaagg tccagatgtt catatgactc tacccaaagg agatatcagt     2220

atttcagggc ccaaggtcaa tgtggaagcc ccagatgtca acttggaggg tctgggggga     2280

aaacttaaag gccccgatgt taagctgcct gatatgagtg tcaagacacc aaagatctcc     2340

atgcctgatg tagatttgca cgtgaaaggt acaaaggtga agggagagta tgatgtaact     2400

gtaccaaagc tggaaggaga actcaaaggc ccaaaagtgg acattgatgc cccagatgtg     2460

gatgttcatg gcccagactg gcacttgaag atgcccaaga tgaaaatgcc caaattcagt     2520

gtgccagggt tcaaagcaga gggcccagaa gtggatgtga acctgcccaa ggctgatgtg     2580

gacatttccg ggcccaagat agatgttact gctcctgatg tgagcattga ggaaccagaa     2640

gggaaattga aagggcccaa gtttaagatg cctgagatga acatcaaagt ccccaagatc     2700

tccatgcctg atgtggactt acatctgaaa ggccctaacg taaagggaga atatgatgtc     2760

acaatgccaa aggttgaaag tgagattaaa gttcctgatg ttgaacttaa aagtgccaaa     2820

atggacattg atgtcccaga tgtggaggtt caaggcccag actggcacct gaagatgccc     2880

aagatgaaaa tgcccaagtt cagcatgcct ggcttcaaag cagagggccc agaagtggat     2940

gtgaacctgc ccaaggctga tgtggacatc tcaggaccca aggtgggtgt tgaagttcca     3000

gatgtgaata ttgaaggacc tgaaggaaag ctgaagggcc ccaagttcaa gatgccagag     3060

atgaatatca aggcccccaa gatctccatg cctgatgtgg acttgcatat gaaaggtcct     3120

aaagtaaagg gagaatatga tatgacagtg ccaaagctgg aaggggacct gaaaggccca     3180

aaagtagatg tcagtgcccc agatgttgaa atgcagggtc ctgactggaa cttgaagatg     3240

ccaaagatta aaatgcccaa atttagcatg cccagcctca aaggagaggg gccagaattt     3300

gatgtgaacc tgtccaaagc gaatgtggac atttctgcac caaaagtaga tactaatgct     3360

ccagatctga gccttgaagg acctgaaggg aagttgaaag gcccgaagtt taagatgcct     3420

gagatgcact tcagagctcc taagatgtct ttgccagatg ttgacctgga tcttaaagga     3480

cccaaaatga aaggaaatgt agatatctct gcaccaaaga tagagggtga aatgcaggtt     3540

ccagatgtgg acatcagagg tcccaaggta gatattaaag caccagatgt ggaaggccaa     3600

ggcctggact ggagcctgaa aatacccaag atgaaaatgc ccaagttcag catgcccagc     3660

ctcaaaggcg agggcccaga agtggatgtg aacttgccta aggctgacgt tgttgtctca     3720

ggacccaagg tggacatcga agccccagat gtgagcctcg aaggtccaga agggaagctg     3780

aagggtccca agtttaagat gcctgagatg catttcaaga cccccaagat ctccatgcct     3840

gatgtggact tacacttgaa aggccccaaa gtcaaagggg atgtggatgt gtctgtgccc     3900

aaggtagaag gtgaaatgaa agtgccagat gttgaaatca aaggacccaa aatggacatt     3960

gatgccccag atgtggaggt tcaaggccca gactggcacc tgaagatgcc caagatgaaa     4020

atgcccaagt ttagcatgcc tggcttcaaa ggagagggcc gagaagtgga tgtgaacctg     4080

cccaaggctg acattgatgt ctcaggaccc aaggtggatg ttgaagtccc agatgtgagc     4140

cttgagggcc cggaaggaaa gctgaagggc cccaagttta agatgcctga gatgcacttc     4200

aaggccccca agatctccat gcctgatgtg gacctgaatc ttaaggggcc aaaattgaag     4260

ggagatgtgg atgtgtcctt gcctgaggta gaaggtgaaa tgaaagtgcc agatgttgac     4320

attaaagggc ccaaagttga cattagtgct ccagatgtgg atgttcatgg cccagattgg     4380

cacctgaaga tgcccaaggt gaaaatgccc aagttcagca tgcccggctt caaaggagag     4440

ggccctgaag tggatgtgaa gctgcccaaa gctgacgttg atgtctcagg acccaaaatg     4500

gatgctgaag ttccagatgt gaatattgaa ggtccagacg caaaactaaa aggtcccaaa     4560

ttcaagatgc cagaaatgag tataaagcct cagaagatat ccataccaga tgttggtttg     4620

catttgaaag gtcctaaaat gaaaggagat tatgatgtaa cagttccaaa agtagaagga     4680

gagataaaag ctcctgatgt tgacatcaaa ggccccaaag ttgatattaa tgcaccagat     4740

gtggaggttc atggcccaga ctggcacctg aagatgccca aggtaaaaat gcccaagttc     4800

agcatgcctg gctttaaagg agagggccca gaggtggata tgaacctgcc caaggctgac     4860

cttggtgttt caggacccaa ggtggacatt gatgttccag atgtgaatct tgaagctcca     4920

gaggggaaac taaaaggccc taagttcaag atgccaagca tgaatataca gacgcacaaa     4980

atctctatgc ctgatgttgg acttaatttg aaagccccta aactgaaaac tgatgtagat     5040

gtttcccttc ccaaagtgga aggagacttg aagggtcctg aaattgatgt gaaagcccct     5100

aagatggatg tgaatgttgg tgatattgat attgaaggtc cagaagggaa gttgaagggc     5160

cccaagttta agatgcctga gatgcatttc aaggccccca agatctccat gcccgatgtg     5220

gacttacact tgaaaggccc caaagtcaaa ggggatatgg atgtgtctgt gcccaaggta     5280

gaaggtgaaa tgaaagtgcc agatgttgac attaaagggc ccaaagtgga cattgatgcc     5340

ccagatgtgg aggttcacga cccagattgg cacctgaaaa tgcccaagat gaaaatgccc     5400

aagttcagta tgcctggctt caaagcagag ggccctgaag tggatgtgaa tctgccaaag     5460

gctgacattg atgtgtctgg acccagtgtg gacactgatg ctcctgattt ggatattgag     5520

ggaccagaag gaaagttgaa aggctccaaa tttaagatgc ccaagttgaa tataaaagct     5580

cccaaggtct ccatgccaga tgtggacttg aatttgaagg gacccaaact gaagggagag     5640

atagatgctt ctgtgccaga actggaaggt gatctcagag ggccgcaagt tgatgtcaaa     5700

ggtccttttg tggaagcgga ggtgcccgat gttgatctgg agtgtcctga tgcaaagttg     5760

aaagggccca agtttaagat gcctgagatg cacttcaagg cccccaagat ctccatgcct     5820

gatgtggact tacacctgaa aggccccaaa gtcaaagggg atgcggatgt gtcggtgcca     5880

aaattggagg gagatttaac aggccccagt gtgggtgtgg aggtgcctga tgttgagctg     5940

gagtgtcctg atgcaaagtt gaaaggccct aaatttaaga tgccagacat gcacttcaag     6000

gcccccaaga tctccatgcc tgatgtggac ttacacttga aaggccccaa agtcaaaggg     6060

gatgtggatg tgtcggtgcc aaaattggag ggagatttaa caggtcccag tgtgggtgtg     6120

gaggtgcctg atgttgagct ggagtgtcct gatgcaaagt tgaaagggcc caagtttaag     6180

atgcctgaga tgcacttcaa gacccccaag atctccatgc ctgatgtgga cttacacctg     6240

aaaggcccca aagtcaaagg ggatatggat gtgtctgtgc ccaaggtaga aggtgaaatg     6300

aaagtgccag atgttgacat caaaggaccc aaaatggaca ttgatgcccc agatgtggat     6360

gttcatggcc cagactggca cctgaagatg cccaagatga aaatgcccaa gttcagcatg     6420

cctggcttca aagcagaggg cccagaagtg gatgtgaact tgcccaaggc tgatgttgtt     6480

gtctcaggac ccaaggtgga tgttgaagtc ccagatgtga gccttgaagg tccagaaggg     6540

aagctgaagg gccccaagct taagatgcct gagatgcact tcaaggcccc caagatctcc     6600

atgcctgatg tggacttaca cttgaaaggc cccaaagtca aaggggatgt ggatgtgtct     6660

ttgccaaaat tggagggaga tttaacaggc cccagtgtgg atgtggaggt gcctgatgtt     6720

gagctggagt gtcctgatgc aaagttgaaa gggcccaagt ttaagatgcc tgagatgcac     6780

ttcaagaccc ccaagatctc catgcctgat gtgaacttaa acttgaaagg ccccaaagtc     6840

aaaggggata tggatgtgtc tgttcccaag gtagaaggtg aaatgaaagt gccagatgtt     6900

gacatcagag ggcccaaagt ggacattgat gccccagatg tggatgttca tggcccagac     6960

tggcacctga agatgcctaa gatgaaaatg cccaagttca gcatgcctgg cttcaaagga     7020

gagggcccag aagtggatgt gaacttgccc aaggctgacg ttgatgtctc aggacccaag     7080

gtggatgttg aagtcccaga tgtgagcctt gaaggtccag aagggaagct gaagggcccc     7140

aagtttaaga tgcctgagat gcacttcaag acccccaaga tctccatgcc tgatgttgat     7200

ttcaatttaa agggacccaa aatcaaagga gatgttgatg tttctgcccc aaagctggag     7260

ggagagttaa aaggtccaga attggatgtc aaaggtccca aattagatgc tgacatgcca     7320

gaagtagctg tggaaggccc aaatggcaag tggaaaactc ctaagttcaa gatgccagat     7380

atgcacttta aagctcccaa aatctctatg ccagacctcg atctacactt gaagagcccc     7440

aaggcaaaag gagaggtgga tgtagatgtt cccaaattgg aaggggacct taaagggcca     7500

catgtggatg tcagtgggcc agacattgac attgagggac cagagggcaa attgaaaggc     7560

cctaagttca agatgcctga tatgcatttc aaagccccca atatttctat gcctgatgtt     7620

gatctaaatc tcaaaggacc caaaatcaag ggggatgtgg atgtgtctgt gcctgaggta     7680

gaaggtaaac ttgaagtacc agatatgaac atcaggggcc ccaaagttga tgtaaatgcc     7740

cccgatgtcc aagctccaga ctggcacctg aagatgccca agatgaaaat gcccaagttc     7800

agcatgcctg gcttcaaagc agagggccct gaagtagacg tcaacttgcc taaggctgac     7860

gttgacatct caggacccaa ggtggacatt gaaggccctg atgttaatat tgaaggacca     7920

gagggaaagt tgaaagggcc taagttaaag atgccagaga tgaacatcaa agcccccaag     7980

atctccatgc ctgactttga tttgcatctg aaaggtccca aggtgaaggg cgatgtggat     8040

gtttctctgc ccaaagtgga aggtgacctc aagggccccg aagttgacat caaggggccc     8100

aaagtggata ttaatgcccc agatgtgggt gttcaaggcc cagactggca cctgaagatg     8160

cccaaggtga aaatgccaaa gttcagcatg cctggcttca aaggagaggg cccagatggg     8220

gatgtgaagc tgcccaaggc tgacattgat gtctcaggac ccaaagtgga cattgaaggc     8280

cctgatgtta acattgaagg accagaggga aagttgaaag ggcctaagtt caagatgcca     8340

gagatgaata tcaaagcccc caagatctcc atgcctgata ttgacttaaa cctgaaagga     8400

cccaaagtga agggtgatgt ggatgtttcc cttcctaaag tggaaggtga cctcaagggc     8460

ccagaagttg acatcaaggg cccaaaagtg gacattgacg cacctgatgt tgatgttcat     8520

ggcccagact ggcacctaaa gatgcccaag ataaaaatgc ccaagatcag catgcctggc     8580

ttcaaaggag aaggtccaga tgtggacgtg aacctgccca aggctgacat tgatgtctca     8640

ggaccgaaag tggatgttga atgtcccgat gtgaatatcg aaggacctga aggaaagtgg     8700

aaaagtccaa agtttaagat gccagagatg cattttaaga ctccaaagat atccatgcca     8760

gatattgacc tgaatctcac aggtccaaaa ataaaaggag atgtggatgt tacaggccct     8820

aaggtagagg gagatctgaa aggtcctgaa gttgacctca aaggccccaa agtggacatt     8880

gatgtcccag atgttaatgt tcagggtcca gactggcacc tgaagatgcc caagatgaaa     8940

atgcccaagt tcagcatgcc tggcttcaaa gcagagggcc ctgaagtgga tgtgaacctg     9000

cccaaggctg acgttgatgt ctcaggcccc aaagtggacg ttgaaggccc tgatgttaac     9060

attgaaggac cagagggaaa gttgaaaggg cccaagttca agatgccaga gatgaatatc     9120

aaagccccca agatccccat gcctgacttt gatttgcatc tgaaaggtcc caaggtgaag     9180

ggcgatgtgg atatttctct gcccaaagtg gaaggtgacc tcaagggccc tgaagttgac     9240

atcaggggtc cccaagtgga cattgatgtc ccggatgtgg gcgttcaagg cccagactgg     9300

cacctaaaaa tgcccaaagt gaaaatgccc aaattcagca tgcctggctt caaaggagag     9360

ggcccagatg tggatgtgaa cctgcccaag gctgaccttg atgtctcagg acccaaggtg     9420

gacattgatg ttccagatgt gaatatcgaa ggcccagagg gaaagttgaa aggtcccaaa     9480

ttcaaaatgc ctgagatgaa catcaaagcc cccaagatct ccatgcctga cattgatctt     9540

aacctgaaag gtcccaaagt gaagggtgac atggatgtgt ctctgccaaa agtggaaggt     9600

gacatgaaag ttcctgacgt ggatattaaa ggccccaaag tggatattaa tgccccagat     9660

gtggatgttc aaggcccaga ctggcacctg aagatgccta aaataaaaat gcccaagatc     9720

agcatgcctg gcttcaaagg agaaggtcca gaagtggacg tgaacctgcc caaggctgac     9780

cttgacgtct caggacccaa ggtggacgtt gatgttccag atgtgaatat tgaaggtcca     9840

gatgcgaaac tgaagggccc taaattcaag atgccagaga tgaacatcaa agctcctaaa     9900

atatcaatgc ctgatttgga cctcaatctt aaaggcccta aaatgaaagg agaggtggat     9960

gtttcacttg caaatgtaga aggtgatttg aaaggacctg ctcttgacat aaaaggccca    10020

aagatagatg tagatgctcc agatattgac attcatggcc cagatgccaa attaaaaggt    10080

ccaaaactga agatgcctga catgcatgta aacatgccca agatctccat gccagaaatt    10140

gacttgaatt tgaaaggctc aaagcttaag ggagatgttg atgtctctgg gcccaagttg    10200

gaaggtgaca ttaaagctcc cagtttggat ataaagggcc cagaagtgga cgtttccggt    10260

cctaagctta atatcgaagg caagtcaaag aaatctcgtt ttaagcttcc caaatttaat    10320

ttttcgggct ctaaagttca gacacctgaa gtggatgtca aaggtaaaaa gccagatatt    10380

gacataacag gtccaaaagt tgatattaat gctcctgatg tcgaggtcca aggaaaagtg    10440

aaaggatcca agtttaaaat gcctttcctg agtatttcat ctcccaaagt ttctatgcct    10500

gacgtggagc taaatttgaa aagtcccaaa gtcaaaggag acttagatat tgcaggtccc    10560

aatttagaag gtgactttaa aggccccaaa gtggatatta aggcaccaga agtcaatctt    10620

aatgcacctg atgtggatgt tcatggtcca gactggaatc tgaaaatgcc caagatgaaa    10680

atgcccaaat tcagtgtgtc tggcttaaaa gcagaagggc cagatgtagc tgtggatcta    10740

ccaaaaggag acatcaacat agagggccca agtatgaaca ttgagggccc agatctcaat    10800

gtggaaggtc cggagggagg cttgaaaggt cccaaattca agatgcctga catgaatatc    10860

aaagctccca agatctccat gcctgacatt gacttaaact tgaaaggccc caaggtgaaa    10920

ggtgatgtgg atatttctct tcccaaactt gaaggggatc tgaaagggcc agaggttgat    10980

atcaaaggcc ctaaagtgga catcaatgcc ccagatgtgg atgttcatgg tccagactgg    11040

catctgaaga tgcccaaagt gaaaatgccc aagttcagca tgcctggctt caaaggagaa    11100

ggccctgaag tcgatgttac cctccctaaa gctgacattg acatttctgg tcccaatgta    11160

gacgttgatg ttccagacgt gaatattgaa ggtccagatg caaagctgaa gggccccaag    11220

ttcaagatgc ctgagatgaa catcaaagcc cccaagatct ccatgcctga ctttgacctg    11280

aacttgaagg gacccaaaat gaagggtgat gtggttgtgt ctttgcccaa agtggaaggt    11340

gatctaaaag gccctgaggt ggacatcaag ggccccaaag tggacattga cactcctgac    11400

attaacatcg aaggctcaga gggtaaattc aagggaccca aatttaagat accagagatg    11460

cacctgaagg ctcccaaaat atcgatgcct gacattgatt taaacctgaa gggccccaaa    11520

gtcaagggcg atgtggatgt ttctctgccc aaaatggaag gtgacctcaa gggtcctgaa    11580

gttgacatca agggccccaa agtggacatt aatgctccag atgttgatgt tcaaggccca    11640

gactggcacc tgaagatgcc caaggtgaaa atgcccaagt tcagcatgcc tggcttcaaa    11700

ggagagggcc cagatgtgga tgtgaacctg cccaaggctg accttgatgt ctcaggaccc    11760

aaggtggaca ttgatgttcc agatgtgaat atcgaaggcc cagagggaaa gttgaaaggt    11820

cccaaattca agatgcctga gatgaacatc aaagccccca agatctccat gcctgacatt    11880

gatcttaacc tgaaaggacc caaagtgaag ggtgatatgg atgtgtctct gccaaaagtg    11940

gaaggtgaca tgcaagttcc tgacttggat attaaaggcc ccaaagtgga tattaatgcc    12000

ccagatgtgg atgttcgagg cccagactgg cacctgaaga tgcctaagat aaaaatgccc    12060

aagatcagca tgcctggctt caaaggagaa ggtccagaag tggatgtgaa cctgcccaag    12120

gctgaccttg acgtctcagg acccaaggtg gacgttgatg ttccagatgt gaatattgaa    12180

ggtccagatg cgaaactgaa gggccctaaa ttcaagatgc cagagatgaa catcaaagcc    12240

cccaagatct ccatgcctga ctttgatttg catctgaaag gccctaaggt gaaaggagat    12300

gtggatgttt ctctgcctaa gatggaaggt gatctaaagg cccctgaagt tgacatcaag    12360

ggccccaaag tggacattga tgccccagat gtggatgttc atggcccaga ctggcacctg    12420

aagatgccca aggtgaaaat gcccaaattc agcatgccag gatttaaagg agagggccca    12480

gaagtggatg ttaatttgcc caaagctgac attgatgtct caggacccaa agtggacatt    12540

gacactcctg atattgatat tcatggtcca gaagggaaac tgaagggccc caaatttaaa    12600

atgcctgacc tgcacctcaa ggcaccgaag atctctatgc ctgaagttga cctgaatctg    12660

aaaggtccaa agatgaaggg cgacgtggac gtttctctgc ccaaagtgga aggcgacctc    12720

aagggccctg aagttgacat caagggcccc aaagtggaca ttgatgtccc agatgtggac    12780

gttcaaggcc cagactggca cttaaaaatg cccaaagtga aaatgcccaa gttcagcatg    12840

cctggcttca aaggagaggg cccagatgtg gatgtgaacc tgcccaaggc tgaccttgac    12900

gtctcaggac ccaaggtgga cattgatgtt cctgatgtga atatcgaagg tccagatgcg    12960

aaactaaagg gccctaaatt caagatgcct gagatgaaca tcaaagcccc caagatctcc    13020

atgcctgact ttgatttgca tctgaaaggt cccaaggtga agggtgatgt ggatgtttcc    13080

cttcctaaag tggaaggtga cctcaagggc ccagaagttg acatcaaggg ccccaaagtg    13140

gacatcgatg cccctgatgt agatgttcat ggcccagact ggcacctgaa gatgcccaag    13200

gtgaaaatgc ccaaattcag catgccagga ttcaaaggag agggcccaga tgtggatgtt    13260

acccttccta aggctgacat tgagatttct ggccccaaag tggacattga tgcccctgat    13320

gtcagtatcg aaggtccaga tgcaaaactc aagggtccaa agttcaagat gccagagatg    13380

aacatcaagg cccccaaaat ctccatgcct gacattgact ttaacttgaa gggtcccaaa    13440

gtgaaaggtg atgtggatgt ctctctgccc aaagtggaag gtgatctcaa gggccctgaa    13500

attgacataa aaggccccag tttggacatt gacacacctg atgtcaatat tgaaggtccg    13560

gaaggaaaat tgaaggggcc caaatttaag atgcctgaga tgaacatcaa agctcccaaa    13620

atctctatgc ctgactttga tttgcacctg aaaggtccca aggtgaaggg tgatgtggat    13680

gtttcactac ctaaggtgga aagtgatctg aaagggccag aggtagacat tgaaggtcct    13740

gaagggaagc tcaaaggtcc caagtttaag atgcctgatg tacatttcaa aagcccacaa    13800

atctccatga gtgacattga tttgaatttg aaaggaccta agataaaagg agatatggac    13860

atttccgttc ctaaactgga gggagatctg aaaggtccca aagtggatgt caaaggccct    13920

aaagtgggca ttgacactcc tgatattgac attcatggtc cagaagggaa actgaagggc    13980

cccaaattta aaatgcctga cttacacctc aaggcaccga agatctctat gcctgaagtt    14040

gacctgaatc tgaaaggtcc aaaggtgaag ggcgacatgg acatttctct gcccaaagtg    14100

gaaggcgacc tcaagggccc cgaagttgac atcagggacc ccaaagtgga cattgatgtc    14160

ccagatgtgg acgttcaagg cccagactgg cacctaaaaa tgcccaaagt gaaaatgccc    14220

aagttcagca tgcctggctt caaaggagag ggcccagatg tggatgtgaa cctgcccaag    14280

gctgacattg atgtctcagg acccaaagtg gacgttgatg ttcctgatgt gaatatcgaa    14340

ggtccagatg cgaaactaaa gggccccaag ttcaagatgc ctgagatgag catcaaagcc    14400

cccaagatct ccatgcctga tattgactta aacctgaaag gacccaaagt gaagggcgat    14460

gtggatgtta cccttcctaa agtggaaggt gacctcaagg gcccagaagc tgacatcaag    14520

ggcccaaaag tggacatcaa cacccctgat gtggatgttc atggcccaga ctggcacctg    14580

aagatgccca aggtgaaaat gcccaaattc agcatgcctg gcttcaaagg agaaggtcca    14640

gatgtggatg tgagcctgcc caaggccgac atcgatgtct cgggacccaa ggtggacgtt    14700

gatattccag atgtgaatat cgaaggtcca gacgcaaaac tgaagggccc caagttcaag    14760

atgcctgaaa taaatatcaa agctcccaag atctccatac ctgatgttga cctggatttg    14820

aaaggaccca aagtaaaagg agattttgat gtgtctgtcc ctaaggttga agggactttg    14880

aaaggcccag aagtagatct taaaggtcca cgtctggatt tcgaaggccc tgatgccaaa    14940

ctcagtggcc catctttgaa gatgccatcg ctggagatat ctgctcctaa agtaactgct    15000

cctgatgttg atttgcatct caaggcacca aaaattggat tttcaggtcc gaagttagaa    15060

ggtggtgaag tggacctcaa gggacccaaa gttgaagctc caagcttaga tgtacacatg    15120

gacagcccag atattaacat cgaagggcca gatgttaaaa tccccaaatt taagaaaccc    15180

aagtttggat ttggggcaaa aagccccaaa gctgacatca agtcaccttc actggatgtc    15240

actgttcctg aggcagagct gaaccttgag actcctgaaa ttagtgttgg tggcaagggc    15300

aagaaaagta agtttaaaat gcctaaaatt catatgagtg gtcctaagat taaggccaaa    15360

aaacagggat ttgacctgaa tgttcctggg ggtgaaattg atgccagcct caaggctccg    15420

gatgtagatg tcaacatcgc agggccggat gctgcactca aagtcgacgt gaaatcgccc    15480

aaaaccaaga aaacgatgtt tggaaaaatg tacttcccag atgtagagtt tgacattaaa    15540

tcacctaaat ttaaagctga ggcccctctc cctagcccca aactggaggg tgaactccag    15600

gcacctgatc tggaactttc tttgccagcg attcacgtcg aaggtcttga catcaaggcg    15660

aaggctccca aggtcaagat gccagatgtg gacatctcag tgccaaaaat agagggtgac    15720

ctgaaaggcc ccaaagtgca ggcaaacttg ggtgcacctg acatcaacat cgaaggccta    15780

gatgctaaag tcaaaacacc gtccttcggc atttctgccc ctcaagtctc catccctgat    15840

gtgaatgtaa acttgaaagg accaaagata aagggtgatg tccccagcgt gggactggaa    15900

ggaccagatg tagatctgca aggtccagaa gcaaaaatta agttccccaa gttttccatg    15960

cccaagatcg gcatcccagg tgtgaaaatg gagggtgggg gagccgaggt ccatgcccag    16020

ctaccctctc ttgaaggaga cttgagagga ccagatgtta agctcgaagg gcccgatgtt    16080

tctctaaagg ggccaggagt agacttgcct tcagtgaacc tctctatgcc aaaagtctct    16140

gggcctgacc ttgatctgaa cttgaaagga ccaagtttga agggagacct ggatgcatct    16200

gttcccagca tgaaggtgca tgctccaggg ctcaacctca gtggtgtcgg tggcaaaatg    16260

caggtgggag gagacggtgt gaaagtgcca gggatcgatg ccacaacaaa gcttaacgtt    16320

ggggcaccag atgtgacact gaggggacca agcctgcagg gagatctggc tgtctctggt    16380

gacatcaaat gccctaaagt atccgtagga gctcctgatc taagcttgga ggcatccgaa    16440

ggcagcatta aacttcccaa aatgaagctg ccccaatttg gcatctctac tccggggtcc    16500

gacttgcacg tcaatgccaa ggggccacag gtttctggcg aactgaaggg gccaggtgtg    16560

gatgtgaacc tgaaagggcc tcggatttca gcaccgaatg tggactttaa cttggaagga    16620

ccaaaagtga aagggagcct tggggccact ggtgagatca aaggccccac tgtcggagga    16680

ggtcttccag gcattggtgt tcaaggccta gaaggaaacc tccagatgcc tggaattaag    16740

tcctctggat gtgatgtgaa cctgccaggc gtgaatgtga aactcccaac tgggcagatt    16800

tctgggcctg aaatcaaagg tggtctgaaa ggttcagaag taggtttcca tggggctgct    16860

cctgatatca gtgtgaaggg gcctgccttt aatatggcat ctcctgagtc agattttggc    16920

atcaacttga agggcccaaa aatcaaagga ggtgcggatg tttcaggggg tgtcagtgcc    16980

ccagacatca gccttggtga agggcatttg agtgttaaag gttccggggg tgagtggaag    17040

ggaccccaag tctcctctgc tctcaacttg gacacatcta agtttgctgg gggccttcat    17100

ttctcaggac caaaggtgga aggaggtgtg aaaggaggtc agattggact ccaggctcct    17160

gggctgagtg tgtctgggcc tcaaggtcac ttggaaagtg gatctggaaa agtaacattc    17220

cctaaaatga agatccccaa atttaccttc tctggccgtg agctggttgg cagagaaatg    17280

ggggtggatg ttcacttccc taaagcagag gccagcatcc aagctggtgc tggagacggc    17340

gagtgggaag agtctgaagt caaactgaaa aagtccaaga tcaaaatgcc caagtttaat    17400

ttttccaaac ctaaagggaa aggtggtgtc actggctcac cagaagcatc aatttctggg    17460

tccaaaggtg acctgaaaag ttcaaaggcc agcctgggct ctctggaagg agaggcagag    17520

gccgaagcct cttcaccgaa aggcaaattc tccttattta aaagtaagaa gccacggcac    17580

cgctcaaatt cattcagtga tgaaagagag ttctctggac cttccacccc gacggggacg    17640

ctggagtttg aaggtgggga agtgtctctg gaaggtggga aagttaaagg gaaacacggg    17700

aagctgaaat tcggtacctt tggtggattg gggtcaaaga gcaaaggtca ttatgaggtg    17760

actgggagcg atgatgagac aggcaagtta caggggagtg gggtgtccct ggcctctaag    17820

aagtcccgac tgtcctcctc ttctagcaat gacagtggga ataaggttgg catccagctt    17880

cccgaggtgg agctgtcagt ttccacaaag aaagagtagc aggcctttgt atgtgtgtac    17940

atatatatat atataacaaa acatcagcct tgggtggtgt gttcctatat aaactccaaa    18000

gggaaacaca ccgactgcct cagcaatcat gcaaagacct tgcctggccc ggtggcaagc    18060

gctgaaaaac cgaccgcctg taggctcctg gaactataca gataggtaaa gagttccaag    18120

ttcgtccagc ccatgtgcaa agtcaacagt atttgcctta agatttcata tatatatatt    18180

tttttgcatt gactgctgag agctcctgtt tactaagcaa gcttttgtgt ttattatcct    18240

catttttact gaacattgtt agttttgggg taatggaaac ccactttttc attgtaatga    18300

ctttgggggc ttttgttagt aagggtgggt ggggtgatgg gttgcagacg gaggtcaggt    18360

cttcctcttt cctgagactg gatctgttca aacagcaaac gcccacagat ggcccagagg    18420

tggtggtagt cagggtgtgt gggtgttttt agggttcttt agtgttgttt ctttcaccca    18480

ggggtggtgg tcccagccag tttggtgctg acggtgagag gaaattagaa tctgtttgca    18540

aattgtccaa cccaccccct caacatgagg ggcttccatt ttctgtgttt tgtaagggaa    18600

ctgtttcctt catgccgcca tgttcctgat attagttctg atttcttttt aacaaatgtt    18660

atcatgatta agaaaatttc cagcacttta atggccaatt aactgagaat gtaagaaaat    18720

tgatgctgta caaggcaaat aaagctgttt attaaccttg a                        18761


<210> 126
<211> 5890
<212> PRT
<213> Homo sapiens

<400> 126
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210> 127
<211> 1036
<212> DNA
<213> Homo sapiens

<400> 127
ggccactcgg agctgctctg ccgcggggac tgcaccgccc gccctgccag acccgcccgg       60

aacggggctc gtcgccgcca gtagccgcag caccgcagcc ttgggcctcg cgccggctat      120

ggccgtgccc tggggctgag ccctcaggtt gtgaccgaga ttcccgacga gagagactga      180

ggggaagaga ggaaggaggg gcgggctcct ggcaaggcat tcgctcctga gcggaatcct      240

gcaaagatgg agaaggagga gacaacccgg gagctgctgc tgcccaactg gcagggtagt      300

ggctcccacg ggctgaccat cgcccagagg gacgacggcg tctttgtgca ggaggtgacg      360

cagaactccc ctgcggcccg cactggggtg gtcaaggagg gggaccagat tgtgggtgcc      420

accatctact ttgacaacct gcagtcgggt gaggtgaccc agctgctgaa caccatgggg      480

caccacacgg tgggcctgaa gctgcaccgc aagggggacc gctctcccga gcctggccag      540

acctggaccc gtgaagtctt cagctcctgc agctctgaag tggttctgaa cacaccacag      600

ccatcagcac tggaatgcaa agaccagaac aaacagaagg aagccagcag ccaagccggg      660

gcagtttcag tctccacccc aaatgcagga ctgtagaagc ggccaggaag aaaaccaccc      720

cctcttaagg ttgtttttgt gaccgttctt tggagcattg ttctaaaaat gggaaattac      780

atattgctgt gccaagggca acaaacacct gcagttaaag gaataccttc cgcgaggcgg      840

cttttcggag catgcatgtt tatagctcca gccaggccag accgagggct gctgcataag      900

ccctgcttgg tgcatttctt tacttgcaag gggacagagt gtgggcttag gtttgggact      960

agagggggct ttggcaacta tggtgctcag gtgattatcc ttcgctcgtt tatccaataa     1020

acatttatca agcatc                                                     1036


<210> 128
<211> 149
<212> PRT
<213> Homo sapiens

<400> 128
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Asn Thr Pro Gln Pro Ser Ala Leu Glu Cys Lys Asp Gln Asn 
        115                 120                 125             


Lys Gln Lys Glu Ala Ser Ser Gln Ala Gly Ala Val Ser Val Ser Thr 
    130                 135                 140                 


Pro Asn Ala Gly Leu 
145                 


<210> 129
<211> 18556
<212> DNA
<213> Homo sapiens

<400> 129
actcggagct gctctgccgc ggggactgca ccgcccgccc tgccagaccc gcccggaacg       60

gggctcgtcg ccgccagtag ccgcagcacc gcagccttgg gcctcgcgcc ggctatggcc      120

gtgccctggg gctgagccct caggttgtga ccgagattcc cgacgagaga gactgagggg      180

aagagaggaa ggaggggcgg gctcctggca aggcattcgc tcctgagcgg aatcctgcaa      240

agatggagaa ggaggagaca acccgggagc tgctgctgcc caactggcag ggtagtggct      300

cccacgggct gaccatcgcc cagagggacg acggcgtctt tgtgcaggag gtgacgcaga      360

actcccctgc ggcccgcact ggggtggtca aggaggggga ccagattgtg ggtgccacca      420

tctactttga caacctgcag tcgggtgagg tgacccagct gctgaacacc atggggcacc      480

acacggtggg cctgaagctg caccgcaagg gggaccgctc tcccgagcct ggccagacct      540

ggacccgtga agtcttcagc tcctgcagct ctgaagtggt tctgagcggg gatgatgagg      600

agtaccagcg catctacacc acgaagatca agccacggct gaagtcggaa gatggagtgg      660

aaggagacct cggggagacc cagagccgta ccatcacagt gaccagaagg gtcacggcct      720

acactgtgga tgtgactggc cgggaaggag ccaaggacat agacatcagt agccctgaat      780

tcaagatcaa gattccaaga catgaactga ctgaaatctc caatgtggat gtggagaccc      840

agtctgggaa gaccgtgatc agactgccct cgggctcggg ggcagcctct ccgacaggct      900

ctgctgtgga tatccgagca ggggccattt ctgcttcagg accagagctc caaggtgctg      960

gccactcgaa gctccaggtc accatgcctg ggataaaggt gggaggctca ggtgtcaatg     1020

tcaatgcaaa gggcttggac ttgggtggca gaggaggggt ccaagttcca gcagtggaca     1080

tttcatcttc tcttgggggt agggcagtag aggtacaggg cccatctctg gagagtggtg     1140

atcatggcaa aattaaattt cccaccatga aagtgccgaa atttggtgtc tcaacagggc     1200

gtgagggcca gacaccaaag gcagggctga gggtttctgc acctgaagtc tctgtggggc     1260

acaagggcgg caagccaggc ttgactatcc aagcccctca gctggaagtc agtgtgccct     1320

ctgccaatat tgagggcctt gaggggaagc tgaagggccc ccaaatcact gggccatcac     1380

ttgagggtga cctaggcctg aaaggtgcca agccacaggg gcacattggg gtggatgcct     1440

ctgctcccca aattgggggt agcatcactg gccccagtgt ggaagttcag gcccctgaca     1500

ttgatgttca ggggcctggg agcaaactga atgtgcccaa gatgaaagtc cccaagttct     1560

ctgtatcagg tgcaaaggga gaggaaactg ggattgatgt gacactgcct acaggtgaag     1620

tgactgttcc tggggtctct ggggatgtca gcctgcctga gattgctact ggtgggctgg     1680

aaggaaagat gaaaggtact aaagtgaaga ctcctgaaat gattattcag aaacctaaaa     1740

tctccatgca ggatgtggat ctgagccttg ggtctcctaa actgaaagga gatattaagg     1800

tttctgctcc tggggtgcaa ggtgatgtta aaggccctca agtggcactt aaaggctcca     1860

gagtggacat agagacacca aacctagagg gaaccttgac aggccctagg cttggcagtc     1920

cttccgggaa aaccggaacc tgtaggatct ctatgtcaga agtagactta aatgtggccg     1980

cacctaaagt gaaagggggt gtagatgtca cactccccag agtagaaggg aaagtcaaag     2040

tccctgaagt tgatgtcaga ggccccaaag tggatgtcag tgccccagat gtcgaagcgc     2100

atggcccaga atggaacctg aaaatgccca agatgaaaat gcccacgttc agcactccag     2160

gagccaaagg ggaaggtcca gatgttcata tgactctacc caaaggagat atcagtattt     2220

cagggcccaa ggtcaatgtg gaagccccag atgtcaactt ggagggtctg gggggaaaac     2280

ttaaaggccc cgatgttaag ctgcctgata tgagtgtcaa gacaccaaag atctccatgc     2340

ctgatgtaga tttgcacgtg aaaggtacaa aggtgaaggg agagtatgat gtaactgtac     2400

caaagctgga aggagaactc aaaggcccaa aagtggacat tgatgcccca gatgtggatg     2460

ttcatggccc agactggcac ttgaagatgc ccaagatgaa aatgcccaaa ttcagtgtgc     2520

cagggttcaa agcagagggc ccagaagtgg atgtgaacct gcccaaggct gatgtggaca     2580

tttccgggcc caagatagat gttactgctc ctgatgtgag cattgaggaa ccagaaggga     2640

aattgaaagg gcccaagttt aagatgcctg agatgaacat caaagtcccc aagatctcca     2700

tgcctgatgt ggacttacat ctgaaaggcc ctaacgtaaa gggagaatat gatgtcacaa     2760

tgccaaaggt tgaaagtgag attaaagttc ctgatgttga acttaaaagt gccaaaatgg     2820

acattgatgt cccagatgtg gaggttcaag gcccagactg gcacctgaag atgcccaaga     2880

tgaaaatgcc caagttcagc atgcctggct tcaaagcaga gggcccagaa gtggatgtga     2940

acctgcccaa ggctgatgtg gacatctcag gacccaaggt gggtgttgaa gttccagatg     3000

tgaatattga aggacctgaa ggaaagctga agggccccaa gttcaagatg ccagagatga     3060

atatcaaggc ccccaagatc tccatgcctg atgtggactt gcatatgaaa ggtcctaaag     3120

taaagggaga atatgatatg acagtgccaa agctggaagg ggacctgaaa ggcccaaaag     3180

tagatgtcag tgccccagat gttgaaatgc agggtcctga ctggaacttg aagatgccaa     3240

agattaaaat gcccaaattt agcatgccca gcctcaaagg agaggggcca gaatttgatg     3300

tgaacctgtc caaagcgaat gtggacattt ctgcaccaaa agtagatact aatgctccag     3360

atctgagcct tgaaggacct gaagggaagt tgaaaggccc gaagtttaag atgcctgaga     3420

tgcacttcag agctcctaag atgtctttgc cagatgttga cctggatctt aaaggaccca     3480

aaatgaaagg aaatgtagat atctctgcac caaagataga gggtgaaatg caggttccag     3540

atgtggacat cagaggtccc aaggtagata ttaaagcacc agatgtggaa ggccaaggcc     3600

tggactggag cctgaaaata cccaagatga aaatgcccaa gttcagcatg cccagcctca     3660

aaggcgaggg cccagaagtg gatgtgaact tgcctaaggc tgacgttgtt gtctcaggac     3720

ccaaggtgga catcgaagcc ccagatgtga gcctcgaagg tccagaaggg aagctgaagg     3780

gtcccaagtt taagatgcct gagatgcatt tcaagacccc caagatctcc atgcctgatg     3840

tggacttaca cttgaaaggc cccaaagtca aaggggatgt ggatgtgtct gtgcccaagg     3900

tagaaggtga aatgaaagtg ccagatgttg aaatcaaagg acccaaaatg gacattgatg     3960

ccccagatgt ggaggttcaa ggcccagact ggcacctgaa gatgcccaag atgaaaatgc     4020

ccaagtttag catgcctggc ttcaaaggag agggccgaga agtggatgtg aacctgccca     4080

aggctgacat tgatgtctca ggacccaagg tggatgttga agtcccagat gtgagccttg     4140

agggcccgga aggaaagctg aagggcccca agtttaagat gcctgagatg cacttcaagg     4200

cccccaagat ctccatgcct gatgtggacc tgaatcttaa ggggccaaaa ttgaagggag     4260

atgtggatgt gtccttgcct gaggtagaag gtgaaatgaa agtgccagat gttgacatta     4320

aagggcccaa agttgacatt agtgctccag atgtggatgt tcatggccca gattggcacc     4380

tgaagatgcc caaggtgaaa atgcccaagt tcagcatgcc cggcttcaaa ggagagggcc     4440

ctgaagtgga tgtgaagctg cccaaagctg acgttgatgt ctcaggaccc aaaatggatg     4500

ctgaagttcc agatgtgaat attgaaggtc cagacgcaaa actaaaaggt cccaaattca     4560

agatgccaga aatgagtata aagcctcaga agatatccat accagatgtt ggtttgcatt     4620

tgaaaggtcc taaaatgaaa ggagattatg atgtaacagt tccaaaagta gaaggagaga     4680

taaaagctcc tgatgttgac atcaaaggcc ccaaagttga tattaatgca ccagatgtgg     4740

aggttcatgg cccagactgg cacctgaaga tgcccaaggt aaaaatgccc aagttcagca     4800

tgcctggctt taaaggagag ggcccagagg tggatatgaa cctgcccaag gctgaccttg     4860

gtgtttcagg acccaaggtg gacattgatg ttccagatgt gaatcttgaa gctccagagg     4920

ggaaactaaa aggccctaag ttcaagatgc caagcatgaa tatacagacg cacaaaatct     4980

ctatgcctga tgttggactt aatttgaaag cccctaaact gaaaactgat gtagatgttt     5040

cccttcccaa agtggaagga gacttgaagg gtcctgaaat tgatgtgaaa gcccctaaga     5100

tggatgtgaa tgttggtgat attgatattg aaggtccaga agggaagttg aagggcccca     5160

agtttaagat gcctgagatg catttcaagg cccccaagat ctccatgccc gatgtggact     5220

tacacttgaa aggccccaaa gtcaaagggg atatggatgt gtctgtgccc aaggtagaag     5280

gtgaaatgaa agtgccagat gttgacatta aagggcccaa agtggacatt gatgccccag     5340

atgtggaggt tcacgaccca gattggcacc tgaaaatgcc caagatgaaa atgcccaagt     5400

tcagtatgcc tggcttcaaa gcagagggcc ctgaagtgga tgtgaatctg ccaaaggctg     5460

acattgatgt gtctggaccc agtgtggaca ctgatgctcc tgatttggat attgagggac     5520

cagaaggaaa gttgaaaggc tccaaattta agatgcccaa gttgaatata aaagctccca     5580

aggtctccat gccagatgtg gacttgaatt tgaagggacc caaactgaag ggagagatag     5640

atgcttctgt gccagaactg gaaggtgatc tcagagggcc gcaagttgat gtcaaaggtc     5700

cttttgtgga agcggaggtg cccgatgttg atctggagtg tcctgatgca aagttgaaag     5760

ggcccaagtt taagatgcct gagatgcact tcaaggcccc caagatctcc atgcctgatg     5820

tggacttaca cctgaaaggc cccaaagtca aaggggatgc ggatgtgtcg gtgccaaaat     5880

tggagggaga tttaacaggc cccagtgtgg gtgtggaggt gcctgatgtt gagctggagt     5940

gtcctgatgc aaagttgaaa ggccctaaat ttaagatgcc agacatgcac ttcaaggccc     6000

ccaagatctc catgcctgat gtggacttac acttgaaagg ccccaaagtc aaaggggatg     6060

tggatgtgtc tgtgcccaag gtagaaggtg aaatgaaagt gccagatgtt gacatcaaag     6120

gacccaaaat ggacattgat gccccagatg tggatgttca tggcccagac tggcacctga     6180

agatgcccaa gatgaaaatg cccaagttca gcatgcctgg cttcaaagca gagggcccag     6240

aagtggatgt gaacttgccc aaggctgatg ttgttgtctc aggacccaag gtggatgttg     6300

aagtcccaga tgtgagcctt gaaggtccag aagggaagct gaagggcccc aagcttaaga     6360

tgcctgagat gcacttcaag gcccccaaga tctccatgcc tgatgtggac ttacacttga     6420

aaggccccaa agtcaaaggg gatgtggatg tgtctttgcc aaaattggag ggagatttaa     6480

caggccccag tgtggatgtg gaggtgcctg atgttgagct ggagtgtcct gatgcaaagt     6540

tgaaagggcc caagtttaag atgcctgaga tgcacttcaa gacccccaag atctccatgc     6600

ctgatgtgaa cttaaacttg aaaggcccca aagtcaaagg ggatatggat gtgtctgttc     6660

ccaaggtaga aggtgaaatg aaagtgccag atgttgacat cagagggccc aaagtggaca     6720

ttgatgcccc agatgtggat gttcatggcc cagactggca cctgaagatg cctaagatga     6780

aaatgcccaa gttcagcatg cctggcttca aaggagaggg cccagaagtg gatgtgaact     6840

tgcccaaggc tgacgttgat gtctcaggac ccaaggtgga tgttgaagtc ccagatgtga     6900

gccttgaagg tccagaaggg aagctgaagg gccccaagtt taagatgcct gagatgcact     6960

tcaagacccc caagatctcc atgcctgatg ttgatttcaa tttaaaggga cccaaaatca     7020

aaggagatgt tgatgtttct gccccaaagc tggagggaga gttaaaaggt ccagaattgg     7080

atgtcaaagg tcccaaatta gatgctgaca tgccagaagt agctgtggaa ggcccaaatg     7140

gcaagtggaa aactcctaag ttcaagatgc cagatatgca ctttaaagct cccaaaatct     7200

ctatgccaga cctcgatcta cacttgaaga gccccaaggc aaaaggagag gtggatgtag     7260

atgttcccaa attggaaggg gaccttaaag ggccacatgt ggatgtcagt gggccagaca     7320

ttgacattga gggaccagag ggcaaattga aaggccctaa gttcaagatg cctgatatgc     7380

atttcaaagc ccccaatatt tctatgcctg atgttgatct aaatctcaaa ggacccaaaa     7440

tcaaggggga tgtggatgtg tctgtgcctg aggtagaagg taaacttgaa gtaccagata     7500

tgaacatcag gggccccaaa gttgatgtaa atgcccccga tgtccaagct ccagactggc     7560

acctgaagat gcccaagatg aaaatgccca agttcagcat gcctggcttc aaagcagagg     7620

gccctgaagt agacgtcaac ttgcctaagg ctgacgttga catctcagga cccaaggtgg     7680

acattgaagg ccctgatgtt aatattgaag gaccagaggg aaagttgaaa gggcctaagt     7740

taaagatgcc agagatgaac atcaaagccc ccaagatctc catgcctgac tttgatttgc     7800

atctgaaagg tcccaaggtg aagggcgatg tggatgtttc tctgcccaaa gtggaaggtg     7860

acctcaaggg ccccgaagtt gacatcaagg ggcccaaagt ggatattaat gccccagatg     7920

tgggtgttca aggcccagac tggcacctga agatgcccaa ggtgaaaatg ccaaagttca     7980

gcatgcctgg cttcaaagga gagggcccag atggggatgt gaagctgccc aaggctgaca     8040

ttgatgtctc aggacccaaa gtggacattg aaggccctga tgttaacatt gaaggaccag     8100

agggaaagtt gaaagggcct aagttcaaga tgccagagat gaatatcaaa gcccccaaga     8160

tctccatgcc tgatattgac ttaaacctga aaggacccaa agtgaagggt gatgtggatg     8220

tttcccttcc taaagtggaa ggtgacctca agggcccaga agttgacatc aagggcccaa     8280

aagtggacat tgacgcacct gatgttgatg ttcatggccc agactggcac ctaaagatgc     8340

ccaagataaa aatgcccaag atcagcatgc ctggcttcaa aggagaaggt ccagatgtgg     8400

acgtgaacct gcccaaggct gacattgatg tctcaggacc gaaagtggat gttgaatgtc     8460

ccgatgtgaa tatcgaagga cctgaaggaa agtggaaaag tccaaagttt aagatgccag     8520

agatgcattt taagactcca aagatatcca tgccagatat tgacctgaat ctcacaggtc     8580

caaaaataaa aggagatgtg gatgttacag gccctaaggt agagggagat ctgaaaggtc     8640

ctgaagttga cctcaaaggc cccaaagtgg acattgatgt cccagatgtt aatgttcagg     8700

gtccagactg gcacctgaag atgcccaaga tgaaaatgcc caagttcagc atgcctggct     8760

tcaaagcaga gggccctgaa gtggatgtga acctgcccaa ggctgacgtt gatgtctcag     8820

gccccaaagt ggacgttgaa ggccctgatg ttaacattga aggaccagag ggaaagttga     8880

aagggcccaa gttcaagatg ccagagatga atatcaaagc ccccaagatc cccatgcctg     8940

actttgattt gcatctgaaa ggtcccaagg tgaagggcga tgtggatatt tctctgccca     9000

aagtggaagg tgacctcaag ggccctgaag ttgacatcag gggtccccaa gtggacattg     9060

atgtcccgga tgtgggcgtt caaggcccag actggcacct aaaaatgccc aaagtgaaaa     9120

tgcccaaatt cagcatgcct ggcttcaaag gagagggccc agatgtggat gtgaacctgc     9180

ccaaggctga ccttgatgtc tcaggaccca aggtggacat tgatgttcca gatgtgaata     9240

tcgaaggccc agagggaaag ttgaaaggtc ccaaattcaa aatgcctgag atgaacatca     9300

aagcccccaa gatctccatg cctgacattg atcttaacct gaaaggtccc aaagtgaagg     9360

gtgacatgga tgtgtctctg ccaaaagtgg aaggtgacat gaaagttcct gacgtggata     9420

ttaaaggccc caaagtggat attaatgccc cagatgtgga tgttcaaggc ccagactggc     9480

acctgaagat gcctaaaata aaaatgccca agatcagcat gcctggcttc aaaggagaag     9540

gtccagaagt ggacgtgaac ctgcccaagg ctgaccttga cgtctcagga cccaaggtgg     9600

acgttgatgt tccagatgtg aatattgaag gtccagatgc gaaactgaag ggccctaaat     9660

tcaagatgcc agagatgaac atcaaagctc ctaaaatatc aatgcctgat ttggacctca     9720

atcttaaagg ccctaaaatg aaaggagagg tggatgtttc acttgcaaat gtagaaggtg     9780

atttgaaagg acctgctctt gacataaaag gcccaaagat agatgtagat gctccagata     9840

ttgacattca tggcccagat gccaaattaa aaggtccaaa actgaagatg cctgacatgc     9900

atgtaaacat gcccaagatc tccatgccag aaattgactt gaatttgaaa ggctcaaagc     9960

ttaagggaga tgttgatgtc tctgggccca agttggaagg tgacattaaa gctcccagtt    10020

tggatataaa gggcccagaa gtggacgttt ccggtcctaa gcttaatatc gaaggcaagt    10080

caaagaaatc tcgttttaag cttcccaaat ttaatttttc gggctctaaa gttcagacac    10140

ctgaagtgga tgtcaaaggt aaaaagccag atattgacat aacaggtcca aaagttgata    10200

ttaatgctcc tgatgtcgag gtccaaggaa aagtgaaagg atccaagttt aaaatgcctt    10260

tcctgagtat ttcatctccc aaagtttcta tgcctgacgt ggagctaaat ttgaaaagtc    10320

ccaaagtcaa aggagactta gatattgcag gtcccaattt agaaggtgac tttaaaggcc    10380

ccaaagtgga tattaaggca ccagaagtca atcttaatgc acctgatgtg gatgttcatg    10440

gtccagactg gaatctgaaa atgcccaaga tgaaaatgcc caaattcagt gtgtctggct    10500

taaaagcaga agggccagat gtagctgtgg atctaccaaa aggagacatc aacatagagg    10560

gcccaagtat gaacattgag ggcccagatc tcaatgtgga aggtccggag ggaggcttga    10620

aaggtcccaa attcaagatg cctgacatga atatcaaagc tcccaagatc tccatgcctg    10680

acattgactt aaacttgaaa ggccccaagg tgaaaggtga tgtggatatt tctcttccca    10740

aacttgaagg ggatctgaaa gggccagagg ttgatatcaa aggccctaaa gtggacatca    10800

atgccccaga tgtggatgtt catggtccag actggcatct gaagatgccc aaagtgaaaa    10860

tgcccaagtt cagcatgcct ggcttcaaag gagaaggccc tgaagtcgat gttaccctcc    10920

ctaaagctga cattgacatt tctggtccca atgtagacgt tgatgttcca gacgtgaata    10980

ttgaaggtcc agatgcaaag ctgaagggcc ccaagttcaa gatgcctgag atgaacatca    11040

aagcccccaa gatctccatg cctgactttg acctgaactt gaagggaccc aaaatgaagg    11100

gtgatgtggt tgtgtctttg cccaaagtgg aaggtgatct aaaaggccct gaggtggaca    11160

tcaagggccc caaagtggac attgacactc ctgacattaa catcgaaggc tcagagggta    11220

aattcaaggg acccaaattt aagataccag agatgcacct gaaggctccc aaaatatcga    11280

tgcctgacat tgatttaaac ctgaagggcc ccaaagtcaa gggcgatgtg gatgtttctc    11340

tgcccaaaat ggaaggtgac ctcaagggtc ctgaagttga catcaagggc cccaaagtgg    11400

acattaatgc tccagatgtt gatgttcaag gcccagactg gcacctgaag atgcccaagg    11460

tgaaaatgcc caagttcagc atgcctggct tcaaaggaga gggcccagat gtggatgtga    11520

acctgcccaa ggctgacctt gatgtctcag gacccaaggt ggacattgat gttccagatg    11580

tgaatatcga aggcccagag ggaaagttga aaggtcccaa attcaagatg cctgagatga    11640

acatcaaagc ccccaagatc tccatgcctg acattgatct taacctgaaa ggacccaaag    11700

tgaagggtga tatggatgtg tctctgccaa aagtggaagg tgacatgcaa gttcctgact    11760

tggatattaa aggccccaaa gtggatatta atgccccaga tgtggatgtt cgaggcccag    11820

actggcacct gaagatgcct aagataaaaa tgcccaagat cagcatgcct ggcttcaaag    11880

gagaaggtcc agaagtggat gtgaacctgc ccaaggctga ccttgacgtc tcaggaccca    11940

aggtggacgt tgatgttcca gatgtgaata ttgaaggtcc agatgcgaaa ctgaagggcc    12000

ctaaattcaa gatgccagag atgaacatca aagcccccaa gatctccatg cctgactttg    12060

atttgcatct gaaaggccct aaggtgaaag gagatgtgga tgtttctctg cctaagatgg    12120

aaggtgatct aaaggcccct gaagttgaca tcaagggccc caaagtggac attgatgccc    12180

cagatgtgga tgttcatggc ccagactggc acctgaagat gcccaaggtg aaaatgccca    12240

aattcagcat gccaggattt aaaggagagg gcccagaagt ggatgttaat ttgcccaaag    12300

ctgacattga tgtctcagga cccaaagtgg acattgacac tcctgatatt gatattcatg    12360

gtccagaagg gaaactgaag ggccccaaat ttaaaatgcc tgacctgcac ctcaaggcac    12420

cgaagatctc tatgcctgaa gttgacctga atctgaaagg tccaaagatg aagggcgacg    12480

tggacgtttc tctgcccaaa gtggaaggcg acctcaaggg ccctgaagtt gacatcaagg    12540

gccccaaagt ggacattgat gtcccagatg tggacgttca aggcccagac tggcacttaa    12600

aaatgcccaa agtgaaaatg cccaagttca gcatgcctgg cttcaaagga gagggcccag    12660

atgtggatgt gaacctgccc aaggctgacc ttgacgtctc aggacccaag gtggacattg    12720

atgttcctga tgtgaatatc gaaggtccag atgcgaaact aaagggccct aaattcaaga    12780

tgcctgagat gaacatcaaa gcccccaaga tctccatgcc tgactttgat ttgcatctga    12840

aaggtcccaa ggtgaagggt gatgtggatg tttcccttcc taaagtggaa ggtgacctca    12900

agggcccaga agttgacatc aagggcccca aagtggacat cgatgcccct gatgtagatg    12960

ttcatggccc agactggcac ctgaagatgc ccaaggtgaa aatgcccaaa ttcagcatgc    13020

caggattcaa aggagagggc ccagatgtgg atgttaccct tcctaaggct gacattgaga    13080

tttctggccc caaagtggac attgatgccc ctgatgtcag tatcgaaggt ccagatgcaa    13140

aactcaaggg tccaaagttc aagatgccag agatgaacat caaggccccc aaaatctcca    13200

tgcctgacat tgactttaac ttgaagggtc ccaaagtgaa aggtgatgtg gatgtctctc    13260

tgcccaaagt ggaaggtgat ctcaagggcc ctgaaattga cataaaaggc cccagtttgg    13320

acattgacac acctgatgtc aatattgaag gtccggaagg aaaattgaag gggcccaaat    13380

ttaagatgcc tgagatgaac atcaaagctc ccaaaatctc tatgcctgac tttgatttgc    13440

acctgaaagg tcccaaggtg aagggtgatg tggatgtttc actacctaag gtggaaagtg    13500

atctgaaagg gccagaggta gacattgaag gtcctgaagg gaagctcaaa ggtcccaagt    13560

ttaagatgcc tgatgtacat ttcaaaagcc cacaaatctc catgagtgac attgatttga    13620

atttgaaagg acctaagata aaaggagata tggacatttc cgttcctaaa ctggagggag    13680

atctgaaagg tcccaaagtg gatgtcaaag gccctaaagt gggcattgac actcctgata    13740

ttgacattca tggtccagaa gggaaactga agggccccaa atttaaaatg cctgacttac    13800

acctcaaggc accgaagatc tctatgcctg aagttgacct gaatctgaaa ggtccaaagg    13860

tgaagggcga catggacatt tctctgccca aagtggaagg cgacctcaag ggccccgaag    13920

ttgacatcag ggaccccaaa gtggacattg atgtcccaga tgtggacgtt caaggcccag    13980

actggcacct aaaaatgccc aaagtgaaaa tgcccaagtt cagcatgcct ggcttcaaag    14040

gagagggccc agatgtggat gtgaacctgc ccaaggctga cattgatgtc tcaggaccca    14100

aagtggacgt tgatgttcct gatgtgaata tcgaaggtcc agatgcgaaa ctaaagggcc    14160

ccaagttcaa gatgcctgag atgagcatca aagcccccaa gatctccatg cctgatattg    14220

acttaaacct gaaaggaccc aaagtgaagg gcgatgtgga tgttaccctt cctaaagtgg    14280

aaggtgacct caagggccca gaagctgaca tcaagggccc aaaagtggac atcaacaccc    14340

ctgatgtgga tgttcatggc ccagactggc acctgaagat gcccaaggtg aaaatgccca    14400

aattcagcat gcctggcttc aaaggagaag gtccagatgt ggatgtgagc ctgcccaagg    14460

ccgacatcga tgtctcggga cccaaggtgg acgttgatat tccagatgtg aatatcgaag    14520

gtccagacgc aaaactgaag ggccccaagt tcaagatgcc tgaaataaat atcaaagctc    14580

ccaagatctc catacctgat gttgacctgg atttgaaagg acccaaagta aaaggagatt    14640

ttgatgtgtc tgtccctaag gttgaaggga ctttgaaagg cccagaagta gatcttaaag    14700

gtccacgtct ggatttcgaa ggccctgatg ccaaactcag tggcccatct ttgaagatgc    14760

catcgctgga gatatctgct cctaaagtaa ctgctcctga tgttgatttg catctcaagg    14820

caccaaaaat tggattttca ggtccgaagt tagaaggtgg tgaagtggac ctcaagggac    14880

ccaaagttga agctccaagc ttagatgtac acatggacag cccagatatt aacatcgaag    14940

ggccagatgt taaaatcccc aaatttaaga aacccaagtt tggatttggg gcaaaaagcc    15000

ccaaagctga catcaagtca ccttcactgg atgtcactgt tcctgaggca gagctgaacc    15060

ttgagactcc tgaaattagt gttggtggca agggcaagaa aagtaagttt aaaatgccta    15120

aaattcatat gagtggtcct aagattaagg ccaaaaaaca gggatttgac ctgaatgttc    15180

ctgggggtga aattgatgcc agcctcaagg ctccggatgt agatgtcaac atcgcagggc    15240

cggatgctgc actcaaagtc gacgtgaaat cgcccaaaac caagaaaacg atgtttggaa    15300

aaatgtactt cccagatgta gagtttgaca ttaaatcacc taaatttaaa gctgaggccc    15360

ctctccctag ccccaaactg gagggtgaac tccaggcacc tgatctggaa ctttctttgc    15420

cagcgattca cgtcgaaggt cttgacatca aggcgaaggc tcccaaggtc aagatgccag    15480

atgtggacat ctcagtgcca aaaatagagg gtgacctgaa aggccccaaa gtgcaggcaa    15540

acttgggtgc acctgacatc aacatcgaag gcctagatgc taaagtcaaa acaccgtcct    15600

tcggcatttc tgcccctcaa gtctccatcc ctgatgtgaa tgtaaacttg aaaggaccaa    15660

agataaaggg tgatgtcccc agcgtgggac tggaaggacc agatgtagat ctgcaaggtc    15720

cagaagcaaa aattaagttc cccaagtttt ccatgcccaa gatcggcatc ccaggtgtga    15780

aaatggaggg tgggggagcc gaggtccatg cccagctacc ctctcttgaa ggagacttga    15840

gaggaccaga tgttaagctc gaagggcccg atgtttctct aaaggggcca ggagtagact    15900

tgccttcagt gaacctctct atgccaaaag tctctgggcc tgaccttgat ctgaacttga    15960

aaggaccaag tttgaaggga gacctggatg catctgttcc cagcatgaag gtgcatgctc    16020

cagggctcaa cctcagtggt gtcggtggca aaatgcaggt gggaggagac ggtgtgaaag    16080

tgccagggat cgatgccaca acaaagctta acgttggggc accagatgtg acactgaggg    16140

gaccaagcct gcagggagat ctggctgtct ctggtgacat caaatgccct aaagtatccg    16200

taggagctcc tgatctaagc ttggaggcat ccgaaggcag cattaaactt cccaaaatga    16260

agctgcccca atttggcatc tctactccgg ggtccgactt gcacgtcaat gccaaggggc    16320

cacaggtttc tggcgaactg aaggggccag gtgtggatgt gaacctgaaa gggcctcgga    16380

tttcagcacc gaatgtggac tttaacttgg aaggaccaaa agtgaaaggg agccttgggg    16440

ccactggtga gatcaaaggc cccactgtcg gaggaggtct tccaggcatt ggtgttcaag    16500

gcctagaagg aaacctccag atgcctggaa ttaagtcctc tggatgtgat gtgaacctgc    16560

caggcgtgaa tgtgaaactc ccaactgggc agatttctgg gcctgaaatc aaaggtggtc    16620

tgaaaggttc agaagtaggt ttccatgggg ctgctcctga tatcagtgtg aaggggcctg    16680

cctttaatat ggcatctcct gagtcagatt ttggcatcaa cttgaagggc ccaaaaatca    16740

aaggaggtgc ggatgtttca gggggtgtca gtgccccaga catcagcctt ggtgaagggc    16800

atttgagtgt taaaggttcc gggggtgagt ggaagggacc ccaagtctcc tctgctctca    16860

acttggacac atctaagttt gctgggggcc ttcatttctc aggaccaaag gtggaaggag    16920

gtgtgaaagg aggtcagatt ggactccagg ctcctgggct gagtgtgtct gggcctcaag    16980

gtcacttgga aagtggatct ggaaaagtaa cattccctaa aatgaagatc cccaaattta    17040

ccttctctgg ccgtgagctg gttggcagag aaatgggggt ggatgttcac ttccctaaag    17100

cagaggccag catccaagct ggtgctggag acggcgagtg ggaagagtct gaagtcaaac    17160

tgaaaaagtc caagatcaaa atgcccaagt ttaatttttc caaacctaaa gggaaaggtg    17220

gtgtcactgg ctcaccagaa gcatcaattt ctgggtccaa aggtgacctg aaaagttcaa    17280

aggccagcct gggctctctg gaaggagagg cagaggccga agcctcttca ccgaaaggca    17340

aattctcctt atttaaaagt aagaagccac ggcaccgctc aaattcattc agtgatgaaa    17400

gagagttctc tggaccttcc accccgacgg ggacgctgga gtttgaaggt ggggaagtgt    17460

ctctggaagg tgggaaagtt aaagggaaac acgggaagct gaaattcggt acctttggtg    17520

gattggggtc aaagagcaaa ggtcattatg aggtgactgg gagcgatgat gagacaggca    17580

agttacaggg gagtggggtg tccctggcct ctaagaagtc ccgactgtcc tcctcttcta    17640

gcaatgacag tgggaataag gttggcatcc agcttcccga ggtggagctg tcagtttcca    17700

caaagaaaga gtagcaggcc tttgtatgtg tgtacatata tatatatata acaaaacatc    17760

agccttgggt ggtgtgttcc tatataaact ccaaagggaa acacaccgac tgcctcagca    17820

atcatgcaaa gaccttgcct ggcccggtgg caagcgctga aaaaccgacc gcctgtaggc    17880

tcctggaact atacagatag gtaaagagtt ccaagttcgt ccagcccatg tgcaaagtca    17940

acagtatttg ccttaagatt tcatatatat atattttttt gcattgactg ctgagagctc    18000

ctgtttacta agcaagcttt tgtgtttatt atcctcattt ttactgaaca ttgttagttt    18060

tggggtaatg gaaacccact ttttcattgt aatgactttg ggggcttttg ttagtaaggg    18120

tgggtggggt gatgggttgc agacggaggt caggtcttcc tctttcctga gactggatct    18180

gttcaaacag caaacgccca cagatggccc agaggtggtg gtagtcaggg tgtgtgggtg    18240

tttttagggt tctttagtgt tgtttctttc acccaggggt ggtggtccca gccagtttgg    18300

tgctgacggt gagaggaaat tagaatctgt ttgcaaattg tccaacccac cccctcaaca    18360

tgaggggctt ccattttctg tgttttgtaa gggaactgtt tccttcatgc cgccatgttc    18420

ctgatattag ttctgatttc tttttaacaa atgttatcat gattaagaaa atttccagca    18480

ctttaatggc caattaactg agaatgtaag aaaattgatg ctgtacaagg caaataaagc    18540

tgtttattaa ccttga                                                    18556


<210> 130
<211> 5823
<212> PRT
<213> Homo sapiens

<400> 130
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Val Glu Gly Glu  Met Lys Val 
    1940                 1945                 1950             


Pro Asp  Val Asp Ile Lys Gly  Pro Lys Met Asp Ile  Asp Ala Pro 
    1955                 1960                 1965             


Asp Val  Asp Val His Gly Pro  Asp Trp His Leu Lys  Met Pro Lys 
    1970                 1975                 1980             


Met Lys  Met Pro Lys Phe Ser  Met Pro Gly Phe Lys  Ala Glu Gly 
    1985                 1990                 1995             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    2000                 2005                 2010             


Gly Pro  Lys Val Asp Val Glu  Val Pro Asp Val Ser  Leu Glu Gly 
    2015                 2020                 2025             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Leu Lys Met  Pro Glu Met 
    2030                 2035                 2040             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    2045                 2050                 2055             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    2060                 2065                 2070             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asn Leu Asn  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Met  Asp Val Ser Val Pro  Lys Val Glu Gly Glu  Met Lys Val 
    2135                 2140                 2145             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Asp Ala Pro 
    2150                 2155                 2160             


Asp Val  Asp Val His Gly Pro  Asp Trp His Leu Lys  Met Pro Lys 
    2165                 2170                 2175             


Met Lys  Met Pro Lys Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly 
    2180                 2185                 2190             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Asp Val Ser 
    2195                 2200                 2205             


Gly Pro  Lys Val Asp Val Glu  Val Pro Asp Val Ser  Leu Glu Gly 
    2210                 2215                 2220             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    2225                 2230                 2235             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Phe Asn 
    2240                 2245                 2250             


Leu Lys  Gly Pro Lys Ile Lys  Gly Asp Val Asp Val  Ser Ala Pro 
    2255                 2260                 2265             


Lys Leu  Glu Gly Glu Leu Lys  Gly Pro Glu Leu Asp  Val Lys Gly 
    2270                 2275                 2280             


Pro Lys  Leu Asp Ala Asp Met  Pro Glu Val Ala Val  Glu Gly Pro 
    2285                 2290                 2295             


Asn Gly  Lys Trp Lys Thr Pro  Lys Phe Lys Met Pro  Asp Met His 
    2300                 2305                 2310             


Phe Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu His Leu 
    2315                 2320                 2325             


Lys Ser  Pro Lys Ala Lys Gly  Glu Val Asp Val Asp  Val Pro Lys 
    2330                 2335                 2340             


Leu Glu  Gly Asp Leu Lys Gly  Pro His Val Asp Val  Ser Gly Pro 
    2345                 2350                 2355             


Asp Ile  Asp Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Asn  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Val Asp Leu Asn Leu  Lys Gly Pro Lys Ile  Lys Gly Asp 
    2390                 2395                 2400             


Val Asp  Val Ser Val Pro Glu  Val Glu Gly Lys Leu  Glu Val Pro 
    2405                 2410                 2415             


Asp Met  Asn Ile Arg Gly Pro  Lys Val Asp Val Asn  Ala Pro Asp 
    2420                 2425                 2430             


Val Gln  Ala Pro Asp Trp His  Leu Lys Met Pro Lys  Met Lys Met 
    2435                 2440                 2445             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val 
    2450                 2455                 2460             


Asp Val  Asn Leu Pro Lys Ala  Asp Val Asp Ile Ser  Gly Pro Lys 
    2465                 2470                 2475             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2480                 2485                 2490             


Lys Leu  Lys Gly Pro Lys Leu  Lys Met Pro Glu Met  Asn Ile Lys 
    2495                 2500                 2505             


Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp Leu His  Leu Lys Gly 
    2510                 2515                 2520             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2525                 2530                 2535             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2540                 2545                 2550             


Asp Ile  Asn Ala Pro Asp Val  Gly Val Gln Gly Pro  Asp Trp His 
    2555                 2560                 2565             


Leu Lys  Met Pro Lys Val Lys  Met Pro Lys Phe Ser  Met Pro Gly 
    2570                 2575                 2580             


Phe Lys  Gly Glu Gly Pro Asp  Gly Asp Val Lys Leu  Pro Lys Ala 
    2585                 2590                 2595             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Ile Glu  Gly Pro Asp 
    2600                 2605                 2610             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe 
    2615                 2620                 2625             


Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro Lys Ile  Ser Met Pro 
    2630                 2635                 2640             


Asp Ile  Asp Leu Asn Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val 
    2645                 2650                 2655             


Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2660                 2665                 2670             


Val Asp  Ile Lys Gly Pro Lys  Val Asp Ile Asp Ala  Pro Asp Val 
    2675                 2680                 2685             


Asp Val  His Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Ile Lys 
    2690                 2695                 2700             


Met Pro  Lys Ile Ser Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp 
    2705                 2710                 2715             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro 
    2720                 2725                 2730             


Lys Val  Asp Val Glu Cys Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2735                 2740                 2745             


Gly Lys  Trp Lys Ser Pro Lys  Phe Lys Met Pro Glu  Met His Phe 
    2750                 2755                 2760             


Lys Thr  Pro Lys Ile Ser Met  Pro Asp Ile Asp Leu  Asn Leu Thr 
    2765                 2770                 2775             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Thr Gly  Pro Lys Val 
    2780                 2785                 2790             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Leu Lys  Gly Pro Lys 
    2795                 2800                 2805             


Val Asp  Ile Asp Val Pro Asp  Val Asn Val Gln Gly  Pro Asp Trp 
    2810                 2815                 2820             


His Leu  Lys Met Pro Lys Met  Lys Met Pro Lys Phe  Ser Met Pro 
    2825                 2830                 2835             


Gly Phe  Lys Ala Glu Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys 
    2840                 2845                 2850             


Ala Asp  Val Asp Val Ser Gly  Pro Lys Val Asp Val  Glu Gly Pro 
    2855                 2860                 2865             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    2870                 2875                 2880             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Pro Met 
    2885                 2890                 2895             


Pro Asp  Phe Asp Leu His Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    2900                 2905                 2910             


Val Asp  Ile Ser Leu Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro 
    2915                 2920                 2925             


Glu Val  Asp Ile Arg Gly Pro  Gln Val Asp Ile Asp  Val Pro Asp 
    2930                 2935                 2940             


Val Gly  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Val 
    2945                 2950                 2955             


Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    2960                 2965                 2970             


Asp Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    2975                 2980                 2985             


Pro Lys  Val Asp Ile Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    2990                 2995                 3000             


Glu Gly  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3005                 3010                 3015             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Ile Asp  Leu Asn Leu 
    3020                 3025                 3030             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Leu Pro Lys 
    3035                 3040                 3045             


Val Glu  Gly Asp Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    3050                 3055                 3060             


Lys Val  Asp Ile Asn Ala Pro  Asp Val Asp Val Gln  Gly Pro Asp 
    3065                 3070                 3075             


Trp His  Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    3095                 3100                 3105             


Lys Ala  Asp Leu Asp Val Ser  Gly Pro Lys Val Asp  Val Asp Val 
    3110                 3115                 3120             


Pro Asp  Val Asn Ile Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro 
    3125                 3130                 3135             


Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser 
    3140                 3145                 3150             


Met Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Lys  Met Lys Gly 
    3155                 3160                 3165             


Glu Val  Asp Val Ser Leu Ala  Asn Val Glu Gly Asp  Leu Lys Gly 
    3170                 3175                 3180             


Pro Ala  Leu Asp Ile Lys Gly  Pro Lys Ile Asp Val  Asp Ala Pro 
    3185                 3190                 3195             


Asp Ile  Asp Ile His Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys 
    3200                 3205                 3210             


Leu Lys  Met Pro Asp Met His  Val Asn Met Pro Lys  Ile Ser Met 
    3215                 3220                 3225             


Pro Glu  Ile Asp Leu Asn Leu  Lys Gly Ser Lys Leu  Lys Gly Asp 
    3230                 3235                 3240             


Val Asp  Val Ser Gly Pro Lys  Leu Glu Gly Asp Ile  Lys Ala Pro 
    3245                 3250                 3255             


Ser Leu  Asp Ile Lys Gly Pro  Glu Val Asp Val Ser  Gly Pro Lys 
    3260                 3265                 3270             


Leu Asn  Ile Glu Gly Lys Ser  Lys Lys Ser Arg Phe  Lys Leu Pro 
    3275                 3280                 3285             


Lys Phe  Asn Phe Ser Gly Ser  Lys Val Gln Thr Pro  Glu Val Asp 
    3290                 3295                 3300             


Val Lys  Gly Lys Lys Pro Asp  Ile Asp Ile Thr Gly  Pro Lys Val 
    3305                 3310                 3315             


Asp Ile  Asn Ala Pro Asp Val  Glu Val Gln Gly Lys  Val Lys Gly 
    3320                 3325                 3330             


Ser Lys  Phe Lys Met Pro Phe  Leu Ser Ile Ser Ser  Pro Lys Val 
    3335                 3340                 3345             


Ser Met  Pro Asp Val Glu Leu  Asn Leu Lys Ser Pro  Lys Val Lys 
    3350                 3355                 3360             


Gly Asp  Leu Asp Ile Ala Gly  Pro Asn Leu Glu Gly  Asp Phe Lys 
    3365                 3370                 3375             


Gly Pro  Lys Val Asp Ile Lys  Ala Pro Glu Val Asn  Leu Asn Ala 
    3380                 3385                 3390             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp Asn Leu  Lys Met Pro 
    3395                 3400                 3405             


Lys Met  Lys Met Pro Lys Phe  Ser Val Ser Gly Leu  Lys Ala Glu 
    3410                 3415                 3420             


Gly Pro  Asp Val Ala Val Asp  Leu Pro Lys Gly Asp  Ile Asn Ile 
    3425                 3430                 3435             


Glu Gly  Pro Ser Met Asn Ile  Glu Gly Pro Asp Leu  Asn Val Glu 
    3440                 3445                 3450             


Gly Pro  Glu Gly Gly Leu Lys  Gly Pro Lys Phe Lys  Met Pro Asp 
    3455                 3460                 3465             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    3470                 3475                 3480             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Ile Ser Leu 
    3485                 3490                 3495             


Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3500                 3505                 3510             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Asp  Val His Gly 
    3515                 3520                 3525             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    3530                 3535                 3540             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Thr 
    3545                 3550                 3555             


Leu Pro  Lys Ala Asp Ile Asp  Ile Ser Gly Pro Asn  Val Asp Val 
    3560                 3565                 3570             


Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    3575                 3580                 3585             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    3590                 3595                 3600             


Ile Ser  Met Pro Asp Phe Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    3605                 3610                 3615             


Lys Gly  Asp Val Val Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    3620                 3625                 3630             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    3635                 3640                 3645             


Thr Pro  Asp Ile Asn Ile Glu  Gly Ser Glu Gly Lys  Phe Lys Gly 
    3650                 3655                 3660             


Pro Lys  Phe Lys Ile Pro Glu  Met His Leu Lys Ala  Pro Lys Ile 
    3665                 3670                 3675             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3680                 3685                 3690             


Gly Asp  Val Asp Val Ser Leu  Pro Lys Met Glu Gly  Asp Leu Lys 
    3695                 3700                 3705             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3710                 3715                 3720             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3725                 3730                 3735             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3740                 3745                 3750             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3755                 3760                 3765             


Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro Asp Val  Asn Ile Glu 
    3770                 3775                 3780             


Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3785                 3790                 3795             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    3800                 3805                 3810             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Met Asp  Val Ser Leu 
    3815                 3820                 3825             


Pro Lys  Val Glu Gly Asp Met  Gln Val Pro Asp Leu  Asp Ile Lys 
    3830                 3835                 3840             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Asp  Val Arg Gly 
    3845                 3850                 3855             


Pro Asp  Trp His Leu Lys Met  Pro Lys Ile Lys Met  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    3875                 3880                 3885             


Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly Pro Lys  Val Asp Val 
    3890                 3895                 3900             


Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    3905                 3910                 3915             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    3920                 3925                 3930             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    3935                 3940                 3945             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Met Glu  Gly Asp Leu 
    3950                 3955                 3960             


Lys Ala  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    3965                 3970                 3975             


Ala Pro  Asp Val Asp Val His  Gly Pro Asp Trp His  Leu Lys Met 
    3980                 3985                 3990             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    3995                 4000                 4005             


Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro Lys Ala  Asp Ile Asp 
    4010                 4015                 4020             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Thr Pro Asp  Ile Asp Ile 
    4025                 4030                 4035             


His Gly  Pro Glu Gly Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4040                 4045                 4050             


Asp Leu  His Leu Lys Ala Pro  Lys Ile Ser Met Pro  Glu Val Asp 
    4055                 4060                 4065             


Leu Asn  Leu Lys Gly Pro Lys  Met Lys Gly Asp Val  Asp Val Ser 
    4070                 4075                 4080             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4085                 4090                 4095             


Lys Gly  Pro Lys Val Asp Ile  Asp Val Pro Asp Val  Asp Val Gln 
    4100                 4105                 4110             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4115                 4120                 4125             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4130                 4135                 4140             


Asn Leu  Pro Lys Ala Asp Leu  Asp Val Ser Gly Pro  Lys Val Asp 
    4145                 4150                 4155             


Ile Asp  Val Pro Asp Val Asn  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4160                 4165                 4170             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4175                 4180                 4185             


Lys Ile  Ser Met Pro Asp Phe  Asp Leu His Leu Lys  Gly Pro Lys 
    4190                 4195                 4200             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4205                 4210                 4215             


Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly Pro Lys  Val Asp Ile 
    4220                 4225                 4230             


Asp Ala  Pro Asp Val Asp Val  His Gly Pro Asp Trp  His Leu Lys 
    4235                 4240                 4245             


Met Pro  Lys Val Lys Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys 
    4250                 4255                 4260             


Gly Glu  Gly Pro Asp Val Asp  Val Thr Leu Pro Lys  Ala Asp Ile 
    4265                 4270                 4275             


Glu Ile  Ser Gly Pro Lys Val  Asp Ile Asp Ala Pro  Asp Val Ser 
    4280                 4285                 4290             


Ile Glu  Gly Pro Asp Ala Lys  Leu Lys Gly Pro Lys  Phe Lys Met 
    4295                 4300                 4305             


Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile Ser Met  Pro Asp Ile 
    4310                 4315                 4320             


Asp Phe  Asn Leu Lys Gly Pro  Lys Val Lys Gly Asp  Val Asp Val 
    4325                 4330                 4335             


Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys Gly Pro  Glu Ile Asp 
    4340                 4345                 4350             


Ile Lys  Gly Pro Ser Leu Asp  Ile Asp Thr Pro Asp  Val Asn Ile 
    4355                 4360                 4365             


Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4370                 4375                 4380             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4385                 4390                 4395             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4400                 4405                 4410             


Leu Pro  Lys Val Glu Ser Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4415                 4420                 4425             


Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4430                 4435                 4440             


Asp Val  His Phe Lys Ser Pro  Gln Ile Ser Met Ser  Asp Ile Asp 
    4445                 4450                 4455             


Leu Asn  Leu Lys Gly Pro Lys  Ile Lys Gly Asp Met  Asp Ile Ser 
    4460                 4465                 4470             


Val Pro  Lys Leu Glu Gly Asp  Leu Lys Gly Pro Lys  Val Asp Val 
    4475                 4480                 4485             


Lys Gly  Pro Lys Val Gly Ile  Asp Thr Pro Asp Ile  Asp Ile His 
    4490                 4495                 4500             


Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Asp 
    4505                 4510                 4515             


Leu His  Leu Lys Ala Pro Lys  Ile Ser Met Pro Glu  Val Asp Leu 
    4520                 4525                 4530             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Met Asp  Ile Ser Leu 
    4535                 4540                 4545             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Arg 
    4550                 4555                 4560             


Asp Pro  Lys Val Asp Ile Asp  Val Pro Asp Val Asp  Val Gln Gly 
    4565                 4570                 4575             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4580                 4585                 4590             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Asn 
    4595                 4600                 4605             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4610                 4615                 4620             


Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4625                 4630                 4635             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Ser Ile Lys  Ala Pro Lys 
    4640                 4645                 4650             


Ile Ser  Met Pro Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Val 
    4655                 4660                 4665             


Lys Gly  Asp Val Asp Val Thr  Leu Pro Lys Val Glu  Gly Asp Leu 
    4670                 4675                 4680             


Lys Gly  Pro Glu Ala Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn 
    4685                 4690                 4695             


Thr Pro  Asp Val Asp Val His  Gly Pro Asp Trp His  Leu Lys Met 
    4700                 4705                 4710             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4715                 4720                 4725             


Glu Gly  Pro Asp Val Asp Val  Ser Leu Pro Lys Ala  Asp Ile Asp 
    4730                 4735                 4740             


Val Ser  Gly Pro Lys Val Asp  Val Asp Ile Pro Asp  Val Asn Ile 
    4745                 4750                 4755             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4760                 4765                 4770             


Glu Ile  Asn Ile Lys Ala Pro  Lys Ile Ser Ile Pro  Asp Val Asp 
    4775                 4780                 4785             


Leu Asp  Leu Lys Gly Pro Lys  Val Lys Gly Asp Phe  Asp Val Ser 
    4790                 4795                 4800             


Val Pro  Lys Val Glu Gly Thr  Leu Lys Gly Pro Glu  Val Asp Leu 
    4805                 4810                 4815             


Lys Gly  Pro Arg Leu Asp Phe  Glu Gly Pro Asp Ala  Lys Leu Ser 
    4820                 4825                 4830             


Gly Pro  Ser Leu Lys Met Pro  Ser Leu Glu Ile Ser  Ala Pro Lys 
    4835                 4840                 4845             


Val Thr  Ala Pro Asp Val Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4850                 4855                 4860             


Gly Phe  Ser Gly Pro Lys Leu  Glu Gly Gly Glu Val  Asp Leu Lys 
    4865                 4870                 4875             


Gly Pro  Lys Val Glu Ala Pro  Ser Leu Asp Val His  Met Asp Ser 
    4880                 4885                 4890             


Pro Asp  Ile Asn Ile Glu Gly  Pro Asp Val Lys Ile  Pro Lys Phe 
    4895                 4900                 4905             


Lys Lys  Pro Lys Phe Gly Phe  Gly Ala Lys Ser Pro  Lys Ala Asp 
    4910                 4915                 4920             


Ile Lys  Ser Pro Ser Leu Asp  Val Thr Val Pro Glu  Ala Glu Leu 
    4925                 4930                 4935             


Asn Leu  Glu Thr Pro Glu Ile  Ser Val Gly Gly Lys  Gly Lys Lys 
    4940                 4945                 4950             


Ser Lys  Phe Lys Met Pro Lys  Ile His Met Ser Gly  Pro Lys Ile 
    4955                 4960                 4965             


Lys Ala  Lys Lys Gln Gly Phe  Asp Leu Asn Val Pro  Gly Gly Glu 
    4970                 4975                 4980             


Ile Asp  Ala Ser Leu Lys Ala  Pro Asp Val Asp Val  Asn Ile Ala 
    4985                 4990                 4995             


Gly Pro  Asp Ala Ala Leu Lys  Val Asp Val Lys Ser  Pro Lys Thr 
    5000                 5005                 5010             


Lys Lys  Thr Met Phe Gly Lys  Met Tyr Phe Pro Asp  Val Glu Phe 
    5015                 5020                 5025             


Asp Ile  Lys Ser Pro Lys Phe  Lys Ala Glu Ala Pro  Leu Pro Ser 
    5030                 5035                 5040             


Pro Lys  Leu Glu Gly Glu Leu  Gln Ala Pro Asp Leu  Glu Leu Ser 
    5045                 5050                 5055             


Leu Pro  Ala Ile His Val Glu  Gly Leu Asp Ile Lys  Ala Lys Ala 
    5060                 5065                 5070             


Pro Lys  Val Lys Met Pro Asp  Val Asp Ile Ser Val  Pro Lys Ile 
    5075                 5080                 5085             


Glu Gly  Asp Leu Lys Gly Pro  Lys Val Gln Ala Asn  Leu Gly Ala 
    5090                 5095                 5100             


Pro Asp  Ile Asn Ile Glu Gly  Leu Asp Ala Lys Val  Lys Thr Pro 
    5105                 5110                 5115             


Ser Phe  Gly Ile Ser Ala Pro  Gln Val Ser Ile Pro  Asp Val Asn 
    5120                 5125                 5130             


Val Asn  Leu Lys Gly Pro Lys  Ile Lys Gly Asp Val  Pro Ser Val 
    5135                 5140                 5145             


Gly Leu  Glu Gly Pro Asp Val  Asp Leu Gln Gly Pro  Glu Ala Lys 
    5150                 5155                 5160             


Ile Lys  Phe Pro Lys Phe Ser  Met Pro Lys Ile Gly  Ile Pro Gly 
    5165                 5170                 5175             


Val Lys  Met Glu Gly Gly Gly  Ala Glu Val His Ala  Gln Leu Pro 
    5180                 5185                 5190             


Ser Leu  Glu Gly Asp Leu Arg  Gly Pro Asp Val Lys  Leu Glu Gly 
    5195                 5200                 5205             


Pro Asp  Val Ser Leu Lys Gly  Pro Gly Val Asp Leu  Pro Ser Val 
    5210                 5215                 5220             


Asn Leu  Ser Met Pro Lys Val  Ser Gly Pro Asp Leu  Asp Leu Asn 
    5225                 5230                 5235             


Leu Lys  Gly Pro Ser Leu Lys  Gly Asp Leu Asp Ala  Ser Val Pro 
    5240                 5245                 5250             


Ser Met  Lys Val His Ala Pro  Gly Leu Asn Leu Ser  Gly Val Gly 
    5255                 5260                 5265             


Gly Lys  Met Gln Val Gly Gly  Asp Gly Val Lys Val  Pro Gly Ile 
    5270                 5275                 5280             


Asp Ala  Thr Thr Lys Leu Asn  Val Gly Ala Pro Asp  Val Thr Leu 
    5285                 5290                 5295             


Arg Gly  Pro Ser Leu Gln Gly  Asp Leu Ala Val Ser  Gly Asp Ile 
    5300                 5305                 5310             


Lys Cys  Pro Lys Val Ser Val  Gly Ala Pro Asp Leu  Ser Leu Glu 
    5315                 5320                 5325             


Ala Ser  Glu Gly Ser Ile Lys  Leu Pro Lys Met Lys  Leu Pro Gln 
    5330                 5335                 5340             


Phe Gly  Ile Ser Thr Pro Gly  Ser Asp Leu His Val  Asn Ala Lys 
    5345                 5350                 5355             


Gly Pro  Gln Val Ser Gly Glu  Leu Lys Gly Pro Gly  Val Asp Val 
    5360                 5365                 5370             


Asn Leu  Lys Gly Pro Arg Ile  Ser Ala Pro Asn Val  Asp Phe Asn 
    5375                 5380                 5385             


Leu Glu  Gly Pro Lys Val Lys  Gly Ser Leu Gly Ala  Thr Gly Glu 
    5390                 5395                 5400             


Ile Lys  Gly Pro Thr Val Gly  Gly Gly Leu Pro Gly  Ile Gly Val 
    5405                 5410                 5415             


Gln Gly  Leu Glu Gly Asn Leu  Gln Met Pro Gly Ile  Lys Ser Ser 
    5420                 5425                 5430             


Gly Cys  Asp Val Asn Leu Pro  Gly Val Asn Val Lys  Leu Pro Thr 
    5435                 5440                 5445             


Gly Gln  Ile Ser Gly Pro Glu  Ile Lys Gly Gly Leu  Lys Gly Ser 
    5450                 5455                 5460             


Glu Val  Gly Phe His Gly Ala  Ala Pro Asp Ile Ser  Val Lys Gly 
    5465                 5470                 5475             


Pro Ala  Phe Asn Met Ala Ser  Pro Glu Ser Asp Phe  Gly Ile Asn 
    5480                 5485                 5490             


Leu Lys  Gly Pro Lys Ile Lys  Gly Gly Ala Asp Val  Ser Gly Gly 
    5495                 5500                 5505             


Val Ser  Ala Pro Asp Ile Ser  Leu Gly Glu Gly His  Leu Ser Val 
    5510                 5515                 5520             


Lys Gly  Ser Gly Gly Glu Trp  Lys Gly Pro Gln Val  Ser Ser Ala 
    5525                 5530                 5535             


Leu Asn  Leu Asp Thr Ser Lys  Phe Ala Gly Gly Leu  His Phe Ser 
    5540                 5545                 5550             


Gly Pro  Lys Val Glu Gly Gly  Val Lys Gly Gly Gln  Ile Gly Leu 
    5555                 5560                 5565             


Gln Ala  Pro Gly Leu Ser Val  Ser Gly Pro Gln Gly  His Leu Glu 
    5570                 5575                 5580             


Ser Gly  Ser Gly Lys Val Thr  Phe Pro Lys Met Lys  Ile Pro Lys 
    5585                 5590                 5595             


Phe Thr  Phe Ser Gly Arg Glu  Leu Val Gly Arg Glu  Met Gly Val 
    5600                 5605                 5610             


Asp Val  His Phe Pro Lys Ala  Glu Ala Ser Ile Gln  Ala Gly Ala 
    5615                 5620                 5625             


Gly Asp  Gly Glu Trp Glu Glu  Ser Glu Val Lys Leu  Lys Lys Ser 
    5630                 5635                 5640             


Lys Ile  Lys Met Pro Lys Phe  Asn Phe Ser Lys Pro  Lys Gly Lys 
    5645                 5650                 5655             


Gly Gly  Val Thr Gly Ser Pro  Glu Ala Ser Ile Ser  Gly Ser Lys 
    5660                 5665                 5670             


Gly Asp  Leu Lys Ser Ser Lys  Ala Ser Leu Gly Ser  Leu Glu Gly 
    5675                 5680                 5685             


Glu Ala  Glu Ala Glu Ala Ser  Ser Pro Lys Gly Lys  Phe Ser Leu 
    5690                 5695                 5700             


Phe Lys  Ser Lys Lys Pro Arg  His Arg Ser Asn Ser  Phe Ser Asp 
    5705                 5710                 5715             


Glu Arg  Glu Phe Ser Gly Pro  Ser Thr Pro Thr Gly  Thr Leu Glu 
    5720                 5725                 5730             


Phe Glu  Gly Gly Glu Val Ser  Leu Glu Gly Gly Lys  Val Lys Gly 
    5735                 5740                 5745             


Lys His  Gly Lys Leu Lys Phe  Gly Thr Phe Gly Gly  Leu Gly Ser 
    5750                 5755                 5760             


Lys Ser  Lys Gly His Tyr Glu  Val Thr Gly Ser Asp  Asp Glu Thr 
    5765                 5770                 5775             


Gly Lys  Leu Gln Gly Ser Gly  Val Ser Leu Ala Ser  Lys Lys Ser 
    5780                 5785                 5790             


Arg Leu  Ser Ser Ser Ser Ser  Asn Asp Ser Gly Asn  Lys Val Gly 
    5795                 5800                 5805             


Ile Gln  Leu Pro Glu Val Glu  Leu Ser Val Ser Thr  Lys Lys Glu 
    5810                 5815                 5820             


