                         SEQUENCE LISTING

<110>  ABBVIE BIOTHERAPEUTICS INC.
 
<120>  METHODS OF TREATMENT OF NON-SMALL-CELL LUNG CARCINOMA 
       USING TELISOTUZUMAB VEDOTIN

<130>  381493-190077

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gly Tyr Ile Phe Thr Ala Tyr Thr Met His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ser Glu Ile Thr Thr Glu Phe Asp Tyr 
1               5                   


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys His 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Lys Ser Ser Glu Ser Val Asp Ser Tyr Ala Asn Ser Phe Leu His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Arg Ala Ser Thr Arg Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Gln Gln Ser Lys Glu Asp Pro Leu Thr 
1               5                   


<210>  9
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  10
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  11
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
atgggatggt cttggatctt tctgctgttt ctgtctggta ctgctggtgt gctgagccag       60

gtccagctgg tgcaatccgg cgcagaggtg aagaagccag gcgcttccgt gaaggtgagc      120

tgtaaggcct ctggctacat cttcacagca tacaccatgc actgggtgag gcaagctcct      180

gggcagggac tggagtggat gggatggatt aaacccaaca atgggctggc caactacgcc      240

cagaaattcc agggtagggt cactatgaca agggatacca gcatcagcac cgcatatatg      300

gagctgagca ggctgaggtc tgacgacact gctgtctatt attgcgccag gagcgaaatt      360

acaacagaat tcgattactg ggggcagggc accctggtga ccgtgtcctc tgccagcacc      420

aagggcccaa gcgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc      480

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc      540

ggagccctca cttctggagt tcataccttc ccagcagtat tgcagagcag tggcctgtat      600

tcactgtctt ccgtcgtaac agttccatcc tccagcctcg ggacacagac ttacatttgt      660

aacgtgaatc acaagcctag caacaccaag gtcgacaaga gagttgaacc aaagagttgt      720

gattgccact gtcctccctg cccagctcct gagctgcttg gcggtcccag tgtcttcttg      780

tttcccccta aacccaaaga caccctgatg atctcaagga ctcccgaggt gacatgcgtg      840

gtggtggatg tgtctcatga ggacccagag gtgaagttca actggtacgt ggacggcgtg      900

gaggtgcaca acgccaagac caagcccaga gaggagcagt acaacagcac ctacagggtg      960

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgtaag     1020

gtgtccaaca aggccctgcc agccccaatc gaaaagacca tcagcaaggc caagggccag     1080

ccaagagagc cccaggtgta caccctgcca cccagcaggg aggagatgac caagaaccag     1140

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag     1200

agcaacggcc agcccgagaa caactacaag accacccccc cagtgctgga cagcgacggc     1260

agcttcttcc tgtacagcaa gctgaccgtg gacaagagca gatggcagca gggcaacgtg     1320

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc     1380

ctgtccccag gctga                                                      1395


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
ggctacatct tcacagcata caccatgcac                                        30


<210>  13
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
tggattaaac ccaacaatgg gctggccaac tacgcccaga aattccaggg t                51


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
agcgaaatta caacagaatt cgattac                                           27


<210>  15
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
gctgatttac agggcttcta ccagggagag cggcgtgccc gataggttca gcggatctgg       60

cagcggcacc gactttacac tgaccatctc cagcctgcag gccgaagatg tggcagtcta      120

ttactgccag cagtccaagg aggaccccct gactttcggg ggtggtacta aagtggagat      180

caagcgtacg gtggccgctc ccagcgtgtt catcttcccc ccaagcgacg agcagctgaa      240

gagcggcacc gccagcgtgg tgtgtctgct gaacaacttc taccccaggg aggccaaggt      300

gcagtggaag gtggacaacg ccctgcagag cggcaacagc caggagagcg tcaccgagca      360

ggacagcaag gactccacct acagcctgag cagcaccctg accctgagca aggccgacta      420

cgagaagcac aaggtgtacg cctgtgaggt gacccaccag ggcctgtcca gccccgtgac      480

caagagcttc aacaggggcg agtgctga                                         508


<210>  16
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
aaaagctccg aatctgtgga ctcttacgca aacagctttc tgcac                       45


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
agggcttcta ccagggagag c                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
cagcagtcca aggaggaccc cctgact                                           27


