﻿                         序列表

<110>  广东东阳光药业有限公司

<120>  一种抗FGF21羧基末端的抗体及其应用

<160>  40

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR1


<400>  1
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      

<210>  2
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR2


<400>  2
Gln Met Ser Ser Leu Ala Ser 
1               5           

<210>  3
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR2


<400>  3
Gln Met Ser Asn Leu Ala Ser 
1               5           

<210>  4
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR3


<400>  4
Ala Gln Thr Leu Glu Leu Pro Thr 
1               5               

<210>  5
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR1


<400>  5
Gly Tyr Thr Phe Thr Asn Tyr 
1               5           

<210>  6
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR2


<400>  6
Asn Thr Tyr Thr Gly Lys 
1               5       

<210>  7
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR3


<400>  7
Asn Tyr Tyr Asp Tyr Asp Val Ala Tyr 
1               5                   

<210>  8
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR3


<400>  8
Asn Tyr Tyr Asp Tyr Asp Ile Ala Tyr 
1               5                   

<210>  9
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  VL


<400>  9
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Val Leu Ile Tyr Gln Met Ser Ser Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Thr 
                85                  90                  95      
Leu Glu Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  10
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  VL


<400>  10
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Val Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Thr 
                85                  90                  95      
Leu Glu Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  11
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  VH


<400>  11
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Thr Gly Glu 
1               5                   10                  15      
Thr Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Leu Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Thr Asn Tyr Tyr Asp Tyr Asp Val Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210>  12
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  VH


<400>  12
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Leu Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Thr Asn Tyr Tyr Asp Tyr Asp Ile Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Ala Val Ser Ala 
        115             

<210>  13
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  CL


<400>  13
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         

<210>  14
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  CL


<400>  14
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  15
<211>  324
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  CH


<400>  15
Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      
Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         
Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 
Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 
Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     
Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         
Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 
Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     
Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             
Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 
Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 
Ser Pro Gly Lys 
                

<210>  16
<211>  325
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  CH


<400>  16
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
1               5                   10                  15      
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            20                  25                  30          
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        35                  40                  45              
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    50                  55                  60                  
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
65                  70                  75                  80  
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                85                  90                  95      
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            100                 105                 110         
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                165                 170                 175     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            180                 185                 190         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        195                 200                 205             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 
Leu Ser Pro Gly Lys 
                325 

<210>  17
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  CH


<400>  17
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Val 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  18
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  SinoA8624


<400>  18
Cys Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
1               5                   10                  15      
Ser 
    

<210>  19
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  SinoA8625


<400>  19
Cys Gly Gly Gly Arg Ser Pro Ser Tyr Ala Ser 
1               5                   10      

<210>  20
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  SinoA8626


<400>  20
Cys Gly Gly Ser Pro Ser Tyr Ala Ser 
1               5                   

<210>  21
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  SinoA8627


<400>  21
Cys Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser 
1               5                   10                  

<210>  22
<211>  424
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  蛋白A


<400>  22
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
                245                 250                 255     
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
            260                 265                 270         
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
        275                 280                 285             
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
    290                 295                 300                 
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
305                 310                 315                 320 
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
                325                 330                 335     
Ser Phe Arg Glu Arg Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
            340                 345                 350         
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His 
        355                 360                 365             
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
    370                 375                 380                 
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
385                 390                 395                 400 
Pro Asp Val Gly Ser Ser Asp Pro Leu His Met Val Gly Ala Ser Gln 
                405                 410                 415     
Gly Leu Ser Pro Ser Tyr Ala Ser 
            420                 

<210>  23
<211>  421
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  蛋白B


<400>  23
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
                245                 250                 255     
Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
            260                 265                 270         
Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
        275                 280                 285             
Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
    290                 295                 300                 
Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
305                 310                 315                 320 
Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
                325                 330                 335     
Ser Phe Arg Glu Arg Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
            340                 345                 350         
Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His 
        355                 360                 365             
Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
    370                 375                 380                 
Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
385                 390                 395                 400 
Pro Asp Val Gly Ser Ser Asp Pro Leu His Met Val Gly Ala Ser Gln 
                405                 410                 415     
Gly Leu Ser Pro Ser 
            420     

<210>  24
<211>  48
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR1


<400>  24
aggtctagta agagtctcct acatagtaat ggcatcactt atttgtat                     48

<210>  25
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR2


<400>  25
cagatgtcca gccttgcctc a                                                  21

<210>  26
<211>  24
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR3


<400>  26
gctcaaactc tagaacttcc gacg                                               24

<210>  27
<211>  237
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  27
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val 
            20                  25                  30          
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Gln Val Leu Ile Tyr Gln Met Ser Ser Leu Ala Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         
Ala Gln Thr Leu Glu Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             
Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 
Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
145                 150                 155                 160 
Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
                165                 170                 175     
Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
            180                 185                 190         
Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
        195                 200                 205             
Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
    210                 215                 220                 
Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235         

<210>  28
<211>  390
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcatagtgac        60
attgtgatga cacaggctgc attctccaat ccagtcactc ttggaacatc agcttccatc       120
tcctgcaggt ctagtaagag tctcctacat agtaatggca tcacttattt gtattggttt       180
ctgcagaagc caggccagtc tcctcaggtc ctgatttatc agatgtccag ccttgcctca       240
ggagtcccag acaggttcag tagcagtggg tcaggaactg atttcacact gagaatcagc       300
agagtggagg ctgaggacgt gggtgtttat tactgtgctc aaactctaga acttccgacg       360
ttcggtggag gcaccaagct ggaaatcaaa                                        390

<210>  29
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR1


<400>  29
ggatatacct tcacaaacta t                                                  21

<210>  30
<211>  18
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR2


<400>  30
aacacctaca ctggaaag                                                      18

<210>  31
<211>  27
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCRD3


<400>  31
aactactatg attacgacgt tgcttac                                            27

<210>  32
<211>  461
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  32
Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      
Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          
Thr Gly Glu Thr Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Lys Leu Met Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala 
65                  70                  75                  80  
Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         
Tyr Phe Cys Ala Thr Asn Tyr Tyr Asp Tyr Asp Val Ala Tyr Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     
Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         
Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             
Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 
Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         
Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             
Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 
Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 
Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                405                 410                 415     
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         
Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             
His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     

<210>  33
<211>  1386
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  33
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag        60
atccagttgg tgcagtctgg acctgagctg aagaagactg gagagacagt caagatgtcc       120
tgcaaggctt ctggatatac cttcacaaac tatggaatga actgggtgaa gcaggctcca       180
ggaaagggtt taaagttgat gggctggata aacacctaca ctggaaagcc aacatatgct       240
gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg       300
cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaac aaactactat       360
gattacgacg ttgcttactg gggccaaggg actctggtca ctgtctctgc agccaaaacg       420
acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg       480
accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct       540
ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact       600
ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac       660
gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt       720
tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag       780
cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc       840
agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca       900
gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt       960
cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca      1020
gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca      1080
caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc      1140
tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag      1200
ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc      1260
tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct      1320
gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt      1380
aaataa                                                                 1386

<210>  34
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  LCDR2


<400>  34
cagatgtcca accttgcctc a                                                  21

<210>  35
<211>  237
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  35
Met Ala Pro Thr Gln Leu Leu Gly Leu Leu Val Leu Trp Ile Pro Gly 
1               5                   10                  15      
Ser Thr Ala Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val 
            20                  25                  30          
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu 
        35                  40                  45              
Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Gln Val Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         
Ala Gln Thr Leu Glu Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             
Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 
Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
145                 150                 155                 160 
Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
                165                 170                 175     
Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
            180                 185                 190         
Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
        195                 200                 205             
Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
    210                 215                 220                 
Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235         

<210>  36
<211>  714
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  36
atggccccaa ctcagctcct ggggctgctt gtgctctgga tccctggatc cactgcagat        60
attgtgatga cgcaggctgc attctccaat ccagtcactc ttggaacatc agcttccatc       120
tcctgcaggt ctagtaagag tctcctacat agtaatggca tcacttattt gtattggttt       180
ctgcagaagc caggccagtc tcctcaggtc ctgatttatc agatgtccaa ccttgcctca       240
ggagtcccag acaggttcag tagcagtggg tcaggaactg atttcacact gagaatcagc       300
agagtggagg ctgaggacgt gggtgtttat tactgtgctc aaactctaga acttccgacg       360
ttcggtggag gcaccaagct ggaaatcaaa cgggctgatg ctgcaccaac tgtatccatc       420
ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac       480
aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat       540
ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag catgagcagc       600
accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg tgaggccact       660
cacaagacat caacttcacc cattgtcaag agcttcaaca ggaatgagtg ctaa             714

<210>  37
<211>  18
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR2


<400>  37
aacacctaca ctggaaaa                                                      18

<210>  38
<211>  27
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<221>
<222>
<223>  HCDR3


<400>  38
aactactatg attacgacat tgcttac                                            27

<210>  39
<211>  461
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  39
Met Gly Trp Val Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      
Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          
Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Lys Leu Met Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala 
65                  70                  75                  80  
Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Leu Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         
Tyr Phe Cys Ala Thr Asn Tyr Tyr Asp Tyr Asp Ile Ala Tyr Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Ala Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     
Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         
Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             
Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 
Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         
Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             
Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 
Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 
Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                405                 410                 415     
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         
Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             
His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     

<210>  40
<211>  1386
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  40
atgggttggg tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaagcacag        60
atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc       120
tgcaaggctt ctggatatac cttcacaaac tatggaatga actgggtgaa gcaggctcca       180
ggaaagggtt taaagttgat gggctggata aacacctaca ctggaaaacc aacatatgct       240
gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg       300
cagctcaaca acctcaagaa tgaggacacg gctacatatt tctgtgcaac aaactactat       360
gattacgaca ttgcttactg gggccagggg actctggtcg ctgtctctgc agccaaaacg       420
acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg       480
accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct       540
ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact       600
ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac       660
gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt       720
tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag       780
cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc       840
agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca       900
gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt       960
cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca      1020
gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca      1080
caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc      1140
tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag      1200
ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc      1260
tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct      1320
gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt      1380
aaataa                                                                 1386

