                         SEQUENCE LISTING

<110>  INSTITUT CURIE
       INSERM (Institut National de la Sant et de la Recherche 
       Mdicale)
       UNIVERSITE PARIS CITE
       NALIO RAMOS, Rodrigo 
       GUERMONPREZ, Pierre
       PIAGGIO, Eliane
       HELFT, Julie
 
<120>  FOLR2+ MACROPHAGES AND ANTI-TUMOR IMMUNITY

<130>  B2106425EPWO

<150>  EP 21305475.2
<151>  2021-04-12

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  1

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  2
<211>  1812
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (sequence encoding anti-murine 
       FOLR2-Fc-antigen)


<220>
<221>  CDS
<222>  (7)..(1806)

<400>  2
gccacc atg ggc tgg agc tgc atc atc ctg ttc ctg gtg gcc acc gcc          48
       Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala            
       1               5                   10                             

acc ggc gtg cac agc ctc gag gac atc gtg atg acc cag agc ccc agc         96
Thr Gly Val His Ser Leu Glu Asp Ile Val Met Thr Gln Ser Pro Ser           
15                  20                  25                  30            

agc ctg gcc gtg agc gcc ggc gag acc gtg acc atc aac tgc aag agc        144
Ser Leu Ala Val Ser Ala Gly Glu Thr Val Thr Ile Asn Cys Lys Ser           
                35                  40                  45                

agc cag agc ctg ctg tac agc ggc aac cag aag aac tac ctg gcc tgg        192
Ser Gln Ser Leu Leu Tyr Ser Gly Asn Gln Lys Asn Tyr Leu Ala Trp           
            50                  55                  60                    

tac cag cag aag ccc ggc cag agc ccc aag ctg ctg atc cac tgg gcc        240
Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Trp Ala           
        65                  70                  75                        

agc acc agg cag agc ggc gtg ccc gac agg ttc atc ggc agc ggc agc        288
Ser Thr Arg Gln Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser           
    80                  85                  90                            

ggc acc gac ttc acc ctg acc atc agc agc gtg cag gcc gag gac ctg        336
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu           
95                  100                 105                 110           

gcc atc tac tac tgc cag cag tac tac gac agc ccc ctg acc ttc ggc        384
Ala Ile Tyr Tyr Cys Gln Gln Tyr Tyr Asp Ser Pro Leu Thr Phe Gly           
                115                 120                 125               

agc ggc acc aag ctg gag atc aag ggc ggc ggc ggc agc ggc ggc ggc        432
Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly           
            130                 135                 140                   

ggc agc ggc ggc ggc ggc agc ggc ggc ggc ggc agc gag gtg cag ctg        480
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu           
        145                 150                 155                       

gtg gag agc ggc ggc ggc ctg gtg cag ccc ggc agg agc ctg aag ctg        528
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu           
    160                 165                 170                           

agc tgc gcc gcc agc ggc ttc acc ttc agc aac tac gac atg gcc tgg        576
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Asp Met Ala Trp           
175                 180                 185                 190           

gtg agg cag gcc ccc acc aag tgc ctg gag tgg gtg gcc agc atc agc        624
Val Arg Gln Ala Pro Thr Lys Cys Leu Glu Trp Val Ala Ser Ile Ser           
                195                 200                 205               

ccc agc ggc gac atc acc tac tac agg gac agc gtg aag ggc agg ttc        672
Pro Ser Gly Asp Ile Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe           
            210                 215                 220                   

acc gtg agc agg gac aac acc aag agc acc ctg ttc ctg cag atg gac        720
Thr Val Ser Arg Asp Asn Thr Lys Ser Thr Leu Phe Leu Gln Met Asp           
        225                 230                 235                       

agc ctg agg agc gag gac acc gcc acc tac tac tgc gcc agg cac ggc        768
Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg His Gly           
    240                 245                 250                           

ccc acc gag gcc ccc gac atc atg gac gcc tgg ggc cag ggc gcc agc        816
Pro Thr Glu Ala Pro Asp Ile Met Asp Ala Trp Gly Gln Gly Ala Ser           
255                 260                 265                 270           

gtg acc gtg agc agc ggc ggc ggc ggc agc gcc gcc gcc gcg gcc gct        864
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala           
                275                 280                 285               

aga tct gct ccc aga ggg ccc aca atc aag ccc tgt cct cca tgc aaa        912
Arg Ser Ala Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys           
            290                 295                 300                   

tgc cca gca cct aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct        960
Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro           
        305                 310                 315                       

cca aag atc aag gat gta ctc atg atc tcc ctg agc ccc ata gtc aca       1008
Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr           
    320                 325                 330                           

tgt gtg gtg gtg gat gtg agc gag gat gac cca gat gtc cag atc agc       1056
Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser           
335                 340                 345                 350           

tgg ttt gtg aac aac gtg gaa gta cac aca gct cag aca caa acc cat       1104
Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His           
                355                 360                 365               

aga gag gat tac gcc agt act ctc cgg gtg gtc agt gcc ctc ccc atc       1152
Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile           
            370                 375                 380                   

cag cac cag gac tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac       1200
Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn           
        385                 390                 395                       

aac aaa gac ctc cca gcg ccc atc gag aga acc atc tca aaa ccc aaa       1248
Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys           
    400                 405                 410                           

ggg tca gta aga gct cca cag gta tat gtc ttg cct cca cca gaa gaa       1296
Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu           
415                 420                 425                 430           

gag atg act aag aaa cag gtc act ctg acc tgc atg gtc aca gac ttc       1344
Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe           
                435                 440                 445               

atg cct gaa gac att tac gtg gag tgg acc aac aac ggg aaa aca gag       1392
Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu           
            450                 455                 460                   

cta aac tac aag aac act gaa cca gtc ctg gac tct gat ggt tct tac       1440
Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr           
        465                 470                 475                       

ttc atg tac agc aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga       1488
Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg           
    480                 485                 490                           

aat agc tac tcc tgt tca gtg gtc cac gag ggt ctg cac aat cac cac       1536
Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His           
495                 500                 505                 510           

acg act aag agc ttc tcc cgg act ccg ggt aaa gcc cgg gca ctg gaa       1584
Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Ala Arg Ala Leu Glu           
                515                 520                 525               

agc atc atc aac ttc gag aag ctg acc gag gcc gcc agc atc tac aga       1632
Ser Ile Ile Asn Phe Glu Lys Leu Thr Glu Ala Ala Ser Ile Tyr Arg           
            530                 535                 540                   

tac tac ggc ctg gcc gct ccc agc agc tcc tac cgg aga cct gtg ggc       1680
Tyr Tyr Gly Leu Ala Ala Pro Ser Ser Ser Tyr Arg Arg Pro Val Gly           
        545                 550                 555                       

atc agc tct aac ttc agc tct ctg gag aac ttc aga gcc tac gtg gac       1728
Ile Ser Ser Asn Phe Ser Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp           
    560                 565                 570                           

ggc cag atc gcc agc aac gag aac atg gaa aca atg gag tct ggg cgc       1776
Gly Gln Ile Ala Ser Asn Glu Asn Met Glu Thr Met Glu Ser Gly Arg           
575                 580                 585                 590           

gcc gac tac aaa gac gat gac gac aag taa gctagc                        1812
Ala Asp Tyr Lys Asp Asp Asp Asp Lys                                       
                595                                                       


<210>  3
<211>  599
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu Glu Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Ser Ala Gly Glu Thr Val Thr Ile Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Gln Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Asp Ser Pro Leu Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Asp Met Ala Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Thr Lys Cys Leu Glu Trp Val Ala Ser Ile Ser Pro Ser 
        195                 200                 205             


Gly Asp Ile Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Val 
    210                 215                 220                 


Ser Arg Asp Asn Thr Lys Ser Thr Leu Phe Leu Gln Met Asp Ser Leu 
225                 230                 235                 240 


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg His Gly Pro Thr 
                245                 250                 255     


Glu Ala Pro Asp Ile Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Arg Ser 
        275                 280                 285             


Ala Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
    290                 295                 300                 


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
305                 310                 315                 320 


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
            340                 345                 350         


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
        355                 360                 365             


Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
    370                 375                 380                 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
385                 390                 395                 400 


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
                405                 410                 415     


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
            420                 425                 430         


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
        435                 440                 445             


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
    450                 455                 460                 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
465                 470                 475                 480 


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
                485                 490                 495     


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
            500                 505                 510         


Lys Ser Phe Ser Arg Thr Pro Gly Lys Ala Arg Ala Leu Glu Ser Ile 
        515                 520                 525             


Ile Asn Phe Glu Lys Leu Thr Glu Ala Ala Ser Ile Tyr Arg Tyr Tyr 
    530                 535                 540                 


Gly Leu Ala Ala Pro Ser Ser Ser Tyr Arg Arg Pro Val Gly Ile Ser 
545                 550                 555                 560 


Ser Asn Phe Ser Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Gln 
                565                 570                 575     


Ile Ala Ser Asn Glu Asn Met Glu Thr Met Glu Ser Gly Arg Ala Asp 
            580                 585                 590         


Tyr Lys Asp Asp Asp Asp Lys 
        595                 


