                         SEQUENCE LISTING

<110>  Imperial College Innovations Limited
 
<120>  Delivery of Gene Therapy Vectors

<130>  P68861WO

<150>  GB2105276.6 
<151>  2021-04-13

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCEF promoter

<400>  1
agatctgtta cataacttat ggtaaatggc ctgcctggct gactgcccaa tgacccctgc       60

ccaatgatgt caataatgat gtatgttccc atgtaatgcc aatagggact ttccattgat      120

gtcaatgggt ggagtattta tggtaactgc ccacttggca gtacatcaag tgtatcatat      180

gccaagtatg ccccctattg atgtcaatga tggtaaatgg cctgcctggc attatgccca      240

gtacatgacc ttatgggact ttcctacttg gcagtacatc tatgtattag tcattgctat      300

taccatggga attcactagt ggagaagagc atgcttgagg gctgagtgcc cctcagtggg      360

cagagagcac atggcccaca gtccctgaga agttgggggg aggggtgggc aattgaactg      420

gtgcctagag aaggtggggc ttgggtaaac tgggaaagtg atgtggtgta ctggctccac      480

ctttttcccc agggtggggg agaaccatat ataagtgcag tagtctctgt gaacattcaa      540

gcttctgcct tctccctcct gtgagtttgc tagc                                  574


<210>  2
<211>  873
<212>  DNA
<213>  Cauliflower mosaic virus

<400>  2
ccgcggagat ctcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggct agc                                   873


<210>  3
<211>  395
<212>  DNA
<213>  Homo sapiens

<400>  3
agatccatat ccgcggcaat tttaaaagaa agggaggaat agggggacag acttcagcag       60

agagactaat taatataata acaacacaat tagaaataca acatttacaa accaaaattc      120

aaaaaatttt aaattttaga gccgcggaga tcccgtgagg ctccggtgcc cgtcagtggg      180

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg      240

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      300

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      360

ttcgcaacgg gtttgccgcc agaacacagg ctagc                                 395


<210>  4
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  soCFTR2

<400>  4
atgcagagaa gccctctgga gaaggcctct gtggtgagca agctgttctt cagctggacc       60

aggcccatcc tgaggaaggg ctacaggcag agactggagc tgtctgacat ctaccagatc      120

ccctctgtgg actctgctga caacctgtct gagaagctgg agagggagtg ggatagagag      180

ctggccagca agaagaaccc caagctgatc aatgccctga ggagatgctt cttctggaga      240

ttcatgttct atggcatctt cctgtacctg ggggaagtga ccaaggctgt gcagcctctg      300

ctgctgggca gaatcattgc cagctatgac cctgacaaca aggaggagag gagcattgcc      360

atctacctgg gcattggcct gtgcctgctg ttcattgtga ggaccctgct gctgcaccct      420

gccatctttg gcctgcacca cattggcatg cagatgagga ttgccatgtt cagcctgatc      480

tacaagaaaa ccctgaagct gtccagcaga gtgctggaca agatcagcat tggccagctg      540

gtgagcctgc tgagcaacaa cctgaacaag tttgatgagg gcctggccct ggcccacttt      600

gtgtggattg cccctctgca ggtggccctg ctgatgggcc tgatttggga gctgctgcag      660

gcctctgcct tttgtggcct gggcttcctg attgtgctgg ccctgtttca ggctggcctg      720

ggcaggatga tgatgaagta cagggaccag agggcaggca agatcagtga gaggctggtg      780

atcacctctg agatgattga gaacatccag tctgtgaagg cctactgttg ggaggaagct      840

atggagaaga tgattgaaaa cctgaggcag acagagctga agctgaccag gaaggctgcc      900

tatgtgagat acttcaacag ctctgccttc ttcttctctg gcttctttgt ggtgttcctg      960

tctgtgctgc cctatgccct gatcaagggg atcatcctga gaaagatttt caccaccatc     1020

agcttctgca ttgtgctgag gatggctgtg accagacagt tcccctgggc tgtgcagacc     1080

tggtatgaca gcctgggggc catcaacaag atccaggact tcctgcagaa gcaggagtac     1140

aagaccctgg agtacaacct gaccaccaca gaagtggtga tggagaatgt gacagccttc     1200

tgggaggagg gctttgggga gctgtttgag aaggccaagc agaacaacaa caacagaaag     1260

accagcaatg gggatgactc cctgttcttc tccaacttct ccctgctggg cacacctgtg     1320

ctgaaggaca tcaacttcaa gattgagagg gggcagctgc tggctgtggc tggatctaca     1380

ggggctggca agaccagcct gctgatgatg atcatggggg agctggagcc ttctgagggc     1440

aagatcaagc actctggcag gatcagcttt tgcagccagt tcagctggat catgcctggc     1500

accatcaagg agaacatcat ctttggagtg agctatgatg agtacagata caggagtgtg     1560

atcaaggcct gccagctgga ggaggacatc agcaagtttg ctgagaagga caacattgtg     1620

ctgggggagg gaggcattac actgtctggg ggccagagag ccagaatcag cctggccagg     1680

gctgtgtaca aggatgctga cctgtacctg ctggactccc cctttggcta cctggatgtg     1740

ctgacagaga aggagatttt tgagagctgt gtgtgcaagc tgatggccaa caagaccaga     1800

atcctggtga ccagcaagat ggagcacctg aagaaggctg acaagatcct gatcctgcat     1860

gagggcagca gctacttcta tgggaccttc tctgagctgc agaacctgca gcctgacttc     1920

agctctaagc tgatgggctg tgacagcttt gaccagttct ctgctgagag gaggaacagc     1980

atcctgacag agaccctgca cagattcagc ctggagggag atgcccctgt gagctggaca     2040

gagaccaaga agcagagctt caagcagaca ggggagtttg gggagaagag gaagaactcc     2100

atcctgaacc ccatcaacag catcaggaag ttcagcattg tgcagaaaac ccccctgcag     2160

atgaatggca ttgaggaaga ttctgatgag cccctggaga ggagactgag cctggtgcct     2220

gattctgagc agggagaggc catcctgcct aggatctctg tgatcagcac aggccctaca     2280

ctgcaggcca gaaggaggca gtctgtgctg aacctgatga cccactctgt gaaccagggc     2340

cagaacatcc acaggaaaac cacagcctcc accaggaaag tgagcctggc ccctcaggcc     2400

aatctgacag agctggacat ctacagcagg aggctgtctc aggagacagg cctggagatt     2460

tctgaggaga tcaatgagga ggacctgaaa gagtgcttct ttgatgacat ggagagcatc     2520

cctgctgtga ccacctggaa cacctacctg agatacatca cagtgcacaa gagcctgatc     2580

tttgtgctga tctggtgcct ggtgatcttc ctggctgaag tggctgcctc tctggtggtg     2640

ctgtggctgc tgggaaacac cccactgcag gacaagggca acagcaccca cagcaggaac     2700

aacagctatg ctgtgatcat cacctccacc tccagctact atgtgttcta catctatgtg     2760

ggagtggctg ataccctgct ggctatgggc ttctttagag gcctgcccct ggtgcacaca     2820

ctgatcacag tgagcaagat cctccaccac aagatgctgc actctgtgct gcaggctcct     2880

atgagcaccc tgaataccct gaaggctggg ggcatcctga acagattctc caaggatatt     2940

gccatcctgg atgacctgct gcctctcacc atctttgact tcatccagct gctgctgatt     3000

gtgattgggg ccattgctgt ggtggcagtg ctgcagccct acatctttgt ggccacagtg     3060

cctgtgattg tggccttcat catgctgagg gcctactttc tgcagacctc ccagcagctg     3120

aagcagctgg agtctgaggg cagaagcccc atcttcaccc acctggtgac aagcctgaag     3180

ggcctgtgga ccctgagagc ctttggcagg cagccctact ttgagaccct gttccacaag     3240

gccctgaacc tgcacacagc caactggttc ctctacctgt ccaccctgag atggttccag     3300

atgagaattg agatgatctt tgtcatcttc ttcattgctg tgaccttcat cagcattctg     3360

accacaggag agggagaggg cagagtgggc attatcctga ccctggccat gaacatcatg     3420

agcacactgc agtgggcagt gaacagcagc attgatgtgg acagcctgat gaggagtgtg     3480

agcagagtgt tcaagttcat tgatatgccc acagagggca agcctaccaa gagcaccaag     3540

ccctacaaga atggccagct gagcaaagtg atgatcattg agaacagcca tgtgaagaag     3600

gatgatatct ggcccagtgg aggccagatg acagtgaagg acctgacagc caagtacaca     3660

gaggggggca atgctatcct ggagaacatc tccttcagca tctcccctgg ccagagagtg     3720

ggactgctgg gaagaacagg ctctggcaag tctaccctgc tgtctgcctt cctgaggctg     3780

ctgaacacag agggagagat ccagattgat ggagtgtcct gggacagcat cacactgcag     3840

cagtggagga aggcctttgg tgtgatcccc cagaaagtgt tcatcttcag tggcaccttc     3900

aggaagaacc tggaccccta tgagcagtgg tctgaccagg agatttggaa agtggctgat     3960

gaagtgggcc tgagaagtgt gattgagcag ttccctggca agctggactt tgtcctggtg     4020

gatgggggct gtgtgctgag ccatggccac aagcagctga tgtgcctggc cagatcagtg     4080

ctgagcaagg ccaagatcct gctgctggat gagccttctg cccacctgga tcctgtgacc     4140

taccagatca tcaggaggac cctcaagcag gcctttgctg actgcacagt catcctgtgt     4200

gagcacagga ttgaggccat gctggagtgc cagcagttcc tggtgattga ggagaacaaa     4260

gtgaggcagt atgacagcat ccagaagctg ctgaatgaga ggagcctgtt caggcaggcc     4320

atcagcccct ctgatagagt gaagctgttc ccccacagga acagctccaa gtgcaagagc     4380

aagccccaga ttgctgccct gaaggaggag acagaggagg aagtgcagga caccaggctg     4440

tga                                                                   4443


<210>  5
<211>  1480
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Met Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  6
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  7
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  8
<211>  426
<212>  DNA
<213>  Mus musculus

<400>  8
atgtggctgc agaacctgct gttcctgggc attgtggtgt acagcctgtc tgcccctaca       60

agatccccta tcacagtgac cagaccttgg aaacatgtgg aagccatcaa agaggccctg      120

aatctgctgg atgacatgcc tgtgacactg aatgaagagg tggaagtggt gtccaatgag      180

ttcagcttca agaaactgac ctgtgtgcag accaggctga agatttttga gcagggcctg      240

agaggcaact tcaccaagct gaaaggggct ctgaacatga cagccagcta ctaccagacc      300

tactgtcctc ctacacctga gacagactgt gaaacccaag tgaccaccta tgctgacttc      360

attgacagcc tcaagacctt cctgacagac atcccctttg agtgcaagaa acctggccag      420

aagtga                                                                 426


<210>  9
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  9

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  10
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  10
atgcccagct ctgtgtcctg gggcattctg ctgctggctg gcctgtgctg tctggtgcct       60

gtgtccctgg ctgaggaccc tcagggggat gctgcccaga aaacagacac ctcccaccat      120

gaccaggacc accccacctt caacaagatc acccccaacc tggcagagtt tgccttcagc      180

ctgtacagac agctggccca ccagagcaac agcaccaaca tctttttcag ccctgtgtcc      240

attgccacag cctttgccat gctgagcctg ggcaccaagg ctgacaccca tgatgagatc      300

ctggaaggcc tgaacttcaa cctgacagag atccctgagg cccagatcca tgagggcttc      360

caggaactgc tgagaaccct gaaccagcca gacagccagc tgcagctgac aacaggcaat      420

gggctgttcc tgtctgaggg cctgaagctg gtggacaagt ttctggaaga tgtgaagaag      480

ctgtaccact ctgaggcctt cacagtgaac tttggggaca cagaagaggc caagaaacag      540

atcaatgact atgtggaaaa gggcacccag ggcaagattg tggaccttgt gaaagagctg      600

gacagggaca ctgtgtttgc ccttgtgaac tacatcttct tcaagggcaa gtgggagagg      660

ccctttgaag tgaaggacac tgaggaagag gacttccatg tggaccaagt gaccacagtg      720

aaggtgccaa tgatgaagag actggggatg ttcaatatcc agcactgcaa gaaactgagc      780

agctgggtgc tgctgatgaa gtacctgggc aatgctacag ccatattctt tctgcctgat      840

gagggcaagc tgcagcacct ggaaaatgag ctgacccatg acatcatcac caaatttctg      900

gaaaatgagg acagaagatc tgccagcctg catctgccca agctgagcat cacaggcaca      960

tatgacctga agtctgtgct gggacagctg ggaatcacca aggtgttcag caatggggca     1020

gacctgagtg gagtgacaga ggaagcccct ctgaagctgt ccaaggctgt gcacaaggca     1080

gtgctgacca ttgatgagaa gggcacagag gctgctgggg ccatgtttct ggaagccatc     1140

cccatgtcca tccccccaga agtgaagttc aacaagccct ttgtgttcct gatgattgag     1200

cagaacacca agagccccct gttcatgggc aaggttgtga accccaccca gaaatga        1257


<210>  11
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  11
tacgggtcga gacacaggac cccgtaagac gacgaccgac cggacacgac agaccacgga       60

cacagggacc gactcctggg agtcccccta cgacgggtct tttgtctgtg gagggtggta      120

ctggtcctgg tggggtggaa gttgttctag tgggggttgg accgtctcaa acggaagtcg      180

gacatgtctg tcgaccgggt ggtctcgttg tcgtggttgt agaaaaagtc gggacacagg      240

taacggtgtc ggaaacggta cgactcggac ccgtggttcc gactgtgggt actactctag      300

gaccttccgg acttgaagtt ggactgtctc tagggactcc gggtctaggt actcccgaag      360

gtccttgacg actcttggga cttggtcggt ctgtcggtcg acgtcgactg ttgtccgtta      420

cccgacaagg acagactccc ggacttcgac cacctgttca aagaccttct acacttcttc      480

gacatggtga gactccggaa gtgtcacttg aaacccctgt gtcttctccg gttctttgtc      540

tagttactga tacacctttt cccgtgggtc ccgttctaac acctggaaca ctttctcgac      600

ctgtccctgt gacacaaacg ggaacacttg atgtagaaga agttcccgtt caccctctcc      660

gggaaacttc acttcctgtg actccttctc ctgaaggtac acctggttca ctggtgtcac      720

ttccacggtt actacttctc tgacccctac aagttatagg tcgtgacgtt ctttgactcg      780

tcgacccacg acgactactt catggacccg ttacgatgtc ggtataagaa agacggacta      840

ctcccgttcg acgtcgtgga ccttttactc gactgggtac tgtagtagtg gtttaaagac      900

cttttactcc tgtcttctag acggtcggac gtagacgggt tcgactcgta gtgtccgtgt      960

atactggact tcagacacga ccctgtcgac ccttagtggt tccacaagtc gttaccccgt     1020

ctggactcac ctcactgtct ccttcgggga gacttcgaca ggttccgaca cgtgttccgt     1080

cacgactggt aactactctt cccgtgtctc cgacgacccc ggtacaaaga ccttcggtag     1140

gggtacaggt aggggggtct tcacttcaag ttgttcggga aacacaagga ctactaactc     1200

gtcttgtggt tctcggggga caagtacccg ttccaacact tggggtgggt ctttact        1257


<210>  12
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Ala 
        35                  40                  45              


Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
    50                  55                  60                  


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
65                  70                  75                  80  


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
                85                  90                  95      


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
            100                 105                 110         


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
        115                 120                 125             


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
    130                 135                 140                 


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
145                 150                 155                 160 


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
                165                 170                 175     


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
            180                 185                 190         


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
        195                 200                 205             


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
    210                 215                 220                 


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
225                 230                 235                 240 


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
                245                 250                 255     


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
            260                 265                 270         


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
        275                 280                 285             


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
    290                 295                 300                 


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
305                 310                 315                 320 


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
                325                 330                 335     


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
            340                 345                 350         


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
        355                 360                 365             


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
    370                 375                 380                 


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
385                 390                 395                 400 


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
                405                 410                 415     


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
            420                 425                 430         


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
        435                 440         


<210>  13
<211>  5013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII N6 transgene

<400>  13
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg ggctgtggag ctgagctggg actacatgca gtctgacctg      120

ggggagctgc ctgtggatgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

acctctgtgg tgtacaagaa gaccctgttt gtggagttca ctgaccacct gttcaacatt      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc tgaggtgtat      300

gacactgtgg tgatcaccct gaagaacatg gccagccacc ctgtgagcct gcatgctgtg      360

ggggtgagct actggaaggc ctctgagggg gctgagtatg atgaccagac cagccagagg      420

gagaaggagg atgacaaggt gttccctggg ggcagccaca cctatgtgtg gcaggtgctg      480

aaggagaatg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccat      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gtttgctgtg      660

tttgatgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggat      720

gctgcctctg ccagggcctg gcccaagatg cacactgtga atggctatgt gaacaggagc      780

ctgcctggcc tgattggctg ccacaggaag tctgtgtact ggcatgtgat tggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ctgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atcagcagcc accagcatga tggcatggag     1020

gcctatgtga aggtggacag ctgccctgag gagccccagc tgaggatgaa gaacaatgag     1080

gaggctgagg actatgatga tgacctgact gactctgaga tggatgtggt gaggtttgat     1140

gatgacaaca gccccagctt catccagatc aggtctgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acattgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aggtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtatg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcact     1500

gatgtgaggc ccctgtacag caggaggctg cccaaggggg tgaagcacct gaaggacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggatggcccc     1620

accaagtctg accccaggtg cctgaccaga tactacagca gctttgtgaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgtc tgacaagagg aatgtgatcc tgttctctgt gtttgatgag     1800

aacaggagct ggtacctgac tgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accctgagtt ccaggccagc aacatcatgc acagcatcaa tggctatgtg     1920

tttgacagcc tgcagctgtc tgtgtgcctg catgaggtgg cctactggta catcctgagc     1980

attggggccc agactgactt cctgtctgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttctctg gggagactgt gttcatgagc     2100

atggagaacc ctggcctgtg gattctgggc tgccacaact ctgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ctggggacta ctatgaggac     2220

agctatgagg acatctctgc ctacctgctg agcaagaaca atgccattga gcccaggagc     2280

ttcagccaga acagcaggca ccccagcacc aggcagaagc agttcaatgc caccaccatc     2340

cctgagaatg acatagagaa gacagaccca tggtttgccc accggacccc catgcccaag     2400

atccagaatg tgagcagctc tgacctgctg atgctgctga ggcagagccc caccccccat     2460

ggcctgagcc tgtctgacct gcaggaggcc aagtatgaaa ccttctctga tgaccccagc     2520

cctggggcca ttgacagcaa caacagcctg tctgagatga cccacttcag gccccagctg     2580

caccactctg gggacatggt gttcacccct gagtctggcc tgcagctgag gctgaatgag     2640

aagctgggca ccactgctgc cactgagctg aagaagctgg acttcaaagt ctccagcacc     2700

agcaacaacc tgatcagcac catcccctct gacaacctgg ctgctggcac tgacaacacc     2760

agcagcctgg gcccccccag catgcctgtg cactatgaca gccagctgga caccaccctg     2820

tttggcaaga agagcagccc cctgactgag tctgggggcc ccctgagcct gtctgaggag     2880

aacaatgaca gcaagctgct ggagtctggc ctgatgaaca gccaggagag cagctggggc     2940

aagaatgtga gcagcaggga gatcaccagg accaccctgc agtctgacca ggaggagatt     3000

gactatgatg acaccatctc tgtggagatg aagaaggagg actttgacat ctacgacgag     3060

gacgagaacc agagccccag gagcttccag aagaagacca ggcactactt cattgctgct     3120

gtggagaggc tgtgggacta tggcatgagc agcagccccc atgtgctgag gaacagggcc     3180

cagtctggct ctgtgcccca gttcaagaag gtggtgttcc aggagttcac tgatggcagc     3240

ttcacccagc ccctgtacag aggggagctg aatgagcacc tgggcctgct gggcccctac     3300

atcagggctg aggtggagga caacatcatg gtgaccttca ggaaccaggc cagcaggccc     3360

tacagcttct acagcagcct gatcagctat gaggaggacc agaggcaggg ggctgagccc     3420

aggaagaact ttgtgaagcc caatgaaacc aagacctact tctggaaggt gcagcaccac     3480

atggccccca ccaaggatga gtttgactgc aaggcctggg cctacttctc tgatgtggac     3540

ctggagaagg atgtgcactc tggcctgatt ggccccctgc tggtgtgcca caccaacacc     3600

ctgaaccctg cccatggcag gcaggtgact gtgcaggagt ttgccctgtt cttcaccatc     3660

tttgatgaaa ccaagagctg gtacttcact gagaacatgg agaggaactg cagggccccc     3720

tgcaacatcc agatggagga ccccaccttc aaggagaact acaggttcca tgccatcaat     3780

ggctacatca tggacaccct gcctggcctg gtgatggccc aggaccagag gatcaggtgg     3840

tacctgctga gcatgggcag caatgagaac atccacagca tccacttctc tggccatgtg     3900

ttcactgtga ggaagaagga ggagtacaag atggccctgt acaacctgta ccctggggtg     3960

tttgagactg tggagatgct gcccagcaag gctggcatct ggagggtgga gtgcctgatt     4020

ggggagcacc tgcatgctgg catgagcacc ctgttcctgg tgtacagcaa caagtgccag     4080

acccccctgg gcatggcctc tggccacatc agggacttcc agatcactgc ctctggccag     4140

tatggccagt gggcccccaa gctggccagg ctgcactact ctggcagcat caatgcctgg     4200

agcaccaagg agcccttcag ctggatcaag gtggacctgc tggcccccat gatcatccat     4260

ggcatcaaga cccagggggc caggcagaag ttcagcagcc tgtacatcag ccagttcatc     4320

atcatgtaca gcctggatgg caagaagtgg cagacctaca ggggcaacag cactggcacc     4380

ctgatggtgt tctttggcaa tgtggacagc tctggcatca agcacaacat cttcaacccc     4440

cccatcattg ccagatacat caggctgcac cccacccact acagcatcag gagcaccctg     4500

aggatggagc tgatgggctg tgacctgaac agctgcagca tgcccctggg catggagagc     4560

aaggccatct ctgatgccca gatcactgcc agcagctact tcaccaacat gtttgccacc     4620

tggagcccca gcaaggccag gctgcacctg cagggcagga gcaatgcctg gaggccccag     4680

gtcaacaacc ccaaggagtg gctgcaggtg gacttccaga agaccatgaa ggtgactggg     4740

gtgaccaccc agggggtgaa gagcctgctg accagcatgt atgtgaagga gttcctgatc     4800

agcagcagcc aggatggcca ccagtggacc ctgttcttcc agaatggcaa ggtgaaggtg     4860

ttccagggca accaggacag cttcacccct gtggtgaaca gcctggaccc ccccctgctg     4920

accagatacc tgaggattca cccccagagc tgggtgcacc agattgccct gaggatggag     4980

gtgctgggct gtgaggccca ggacctgtac tga                                  5013


<210>  14
<211>  4425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII V3 transgene

<400>  14
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc       60

accaggagat actacctggg ggctgtggag ctgagctggg actacatgca gtctgacctg      120

ggggagctgc ctgtggatgc caggttcccc cccagagtgc ccaagagctt ccccttcaac      180

acctctgtgg tgtacaagaa gaccctgttt gtggagttca ctgaccacct gttcaacatt      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc tgaggtgtat      300

gacactgtgg tgatcaccct gaagaacatg gccagccacc ctgtgagcct gcatgctgtg      360

ggggtgagct actggaaggc ctctgagggg gctgagtatg atgaccagac cagccagagg      420

gagaaggagg atgacaaggt gttccctggg ggcagccaca cctatgtgtg gcaggtgctg      480

aaggagaatg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccat      540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag      600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gtttgctgtg      660

tttgatgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggat      720

gctgcctctg ccagggcctg gcccaagatg cacactgtga atggctatgt gaacaggagc      780

ctgcctggcc tgattggctg ccacaggaag tctgtgtact ggcatgtgat tggcatgggc      840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac      900

aggcaggcca gcctggagat cagccccatc accttcctga ctgcccagac cctgctgatg      960

gacctgggcc agttcctgct gttctgccac atcagcagcc accagcatga tggcatggag     1020

gcctatgtga aggtggacag ctgccctgag gagccccagc tgaggatgaa gaacaatgag     1080

gaggctgagg actatgatga tgacctgact gactctgaga tggatgtggt gaggtttgat     1140

gatgacaaca gccccagctt catccagatc aggtctgtgg ccaagaagca ccccaagacc     1200

tgggtgcact acattgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc     1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg     1320

aagtacaaga aggtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc     1380

atccagcatg agtctggcat cctgggcccc ctgctgtatg gggaggtggg ggacaccctg     1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcact     1500

gatgtgaggc ccctgtacag caggaggctg cccaaggggg tgaagcacct gaaggacttc     1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggatggcccc     1620

accaagtctg accccaggtg cctgaccaga tactacagca gctttgtgaa catggagagg     1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag     1740

aggggcaacc agatcatgtc tgacaagagg aatgtgatcc tgttctctgt gtttgatgag     1800

aacaggagct ggtacctgac tgagaacatc cagaggttcc tgcccaaccc tgctggggtg     1860

cagctggagg accctgagtt ccaggccagc aacatcatgc acagcatcaa tggctatgtg     1920

tttgacagcc tgcagctgtc tgtgtgcctg catgaggtgg cctactggta catcctgagc     1980

attggggccc agactgactt cctgtctgtg ttcttctctg gctacacctt caagcacaag     2040

atggtgtatg aggacaccct gaccctgttc cccttctctg gggagactgt gttcatgagc     2100

atggagaacc ctggcctgtg gattctgggc tgccacaact ctgacttcag gaacaggggc     2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ctggggacta ctatgaggac     2220

agctatgagg acatctctgc ctacctgctg agcaagaaca atgccattga gcccaggagc     2280

ttcagccaga atgccactaa tgtgtctaac aacagcaaca ccagcaatga cagcaatgtg     2340

tctcccccag tgctgaagag gcaccagagg gagatcacca ggaccaccct gcagtctgac     2400

caggaggaga ttgactatga tgacaccatc tctgtggaga tgaagaagga ggactttgac     2460

atctacgacg aggacgagaa ccagagcccc aggagcttcc agaagaagac caggcactac     2520

ttcattgctg ctgtggagag gctgtgggac tatggcatga gcagcagccc ccatgtgctg     2580

aggaacaggg cccagtctgg ctctgtgccc cagttcaaga aggtggtgtt ccaggagttc     2640

actgatggca gcttcaccca gcccctgtac agaggggagc tgaatgagca cctgggcctg     2700

ctgggcccct acatcagggc tgaggtggag gacaacatca tggtgacctt caggaaccag     2760

gccagcaggc cctacagctt ctacagcagc ctgatcagct atgaggagga ccagaggcag     2820

ggggctgagc ccaggaagaa ctttgtgaag cccaatgaaa ccaagaccta cttctggaag     2880

gtgcagcacc acatggcccc caccaaggat gagtttgact gcaaggcctg ggcctacttc     2940

tctgatgtgg acctggagaa ggatgtgcac tctggcctga ttggccccct gctggtgtgc     3000

cacaccaaca ccctgaaccc tgcccatggc aggcaggtga ctgtgcagga gtttgccctg     3060

ttcttcacca tctttgatga aaccaagagc tggtacttca ctgagaacat ggagaggaac     3120

tgcagggccc cctgcaacat ccagatggag gaccccacct tcaaggagaa ctacaggttc     3180

catgccatca atggctacat catggacacc ctgcctggcc tggtgatggc ccaggaccag     3240

aggatcaggt ggtacctgct gagcatgggc agcaatgaga acatccacag catccacttc     3300

tctggccatg tgttcactgt gaggaagaag gaggagtaca agatggccct gtacaacctg     3360

taccctgggg tgtttgagac tgtggagatg ctgcccagca aggctggcat ctggagggtg     3420

gagtgcctga ttggggagca cctgcatgct ggcatgagca ccctgttcct ggtgtacagc     3480

aacaagtgcc agacccccct gggcatggcc tctggccaca tcagggactt ccagatcact     3540

gcctctggcc agtatggcca gtgggccccc aagctggcca ggctgcacta ctctggcagc     3600

atcaatgcct ggagcaccaa ggagcccttc agctggatca aggtggacct gctggccccc     3660

atgatcatcc atggcatcaa gacccagggg gccaggcaga agttcagcag cctgtacatc     3720

agccagttca tcatcatgta cagcctggat ggcaagaagt ggcagaccta caggggcaac     3780

agcactggca ccctgatggt gttctttggc aatgtggaca gctctggcat caagcacaac     3840

atcttcaacc cccccatcat tgccagatac atcaggctgc accccaccca ctacagcatc     3900

aggagcaccc tgaggatgga gctgatgggc tgtgacctga acagctgcag catgcccctg     3960

ggcatggaga gcaaggccat ctctgatgcc cagatcactg ccagcagcta cttcaccaac     4020

atgtttgcca cctggagccc cagcaaggcc aggctgcacc tgcagggcag gagcaatgcc     4080

tggaggcccc aggtcaacaa ccccaaggag tggctgcagg tggacttcca gaagaccatg     4140

aaggtgactg gggtgaccac ccagggggtg aagagcctgc tgaccagcat gtatgtgaag     4200

gagttcctga tcagcagcag ccaggatggc caccagtgga ccctgttctt ccagaatggc     4260

aaggtgaagg tgttccaggg caaccaggac agcttcaccc ctgtggtgaa cagcctggac     4320

ccccccctgc tgaccagata cctgaggatt cacccccaga gctgggtgca ccagattgcc     4380

ctgaggatgg aggtgctggg ctgtgaggcc caggacctgt actga                     4425


<210>  15
<211>  5013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complementary strand to FVIII transgene (N6)

<400>  15
tacgtctaac tcgactcgtg gacgaagaag gacacggacg actccaagac gaagagacgg       60

tggtcctcta tgatggaccc ccgacacctc gactcgaccc tgatgtacgt cagactggac      120

cccctcgacg gacacctacg gtccaagggg gggtctcacg ggttctcgaa ggggaagttg      180

tggagacacc acatgttctt ctgggacaaa cacctcaagt gactggtgga caagttgtaa      240

cggttcgggt ccggggggac ctacccggac gacccggggt ggtaggtccg actccacata      300

ctgtgacacc actagtggga cttcttgtac cggtcggtgg gacactcgga cgtacgacac      360

ccccactcga tgaccttccg gagactcccc cgactcatac tactggtctg gtcggtctcc      420

ctcttcctcc tactgttcca caagggaccc ccgtcggtgt ggatacacac cgtccacgac      480

ttcctcttac cggggtaccg gagactgggg gacacggact ggatgtcgat ggactcggta      540

cacctggacc acttcctgga cttgagaccg gactaacccc gggacgacca cacgtccctc      600

ccgtcggacc ggttcctctt ctgggtctgg gacgtgttca agtaggacga caaacgacac      660

aaactactcc cgttctcgac cgtgagactt tggttcttgt cggactacgt cctgtcccta      720

cgacggagac ggtcccggac cgggttctac gtgtgacact taccgataca cttgtcctcg      780

gacggaccgg actaaccgac ggtgtccttc agacacatga ccgtacacta accgtacccg      840

tggtggggac tccacgtgtc gtagaaggac ctcccggtgt ggaaggacca gtccttggtg      900

tccgtccggt cggacctcta gtcggggtag tggaaggact gacgggtctg ggacgactac      960

ctggacccgg tcaaggacga caagacggtg tagtcgtcgg tggtcgtact accgtacctc     1020

cggatacact tccacctgtc gacgggactc ctcggggtcg actcctactt cttgttactc     1080

ctccgactcc tgatactact actggactga ctgagactct acctacacca ctccaaacta     1140

ctactgttgt cggggtcgaa gtaggtctag tccagacacc ggttcttcgt ggggttctgg     1200

acccacgtga tgtaacgacg actcctcctc ctgaccctga tacgggggga ccacgaccgg     1260

ggactactgt cctcgatgtt ctcggtcatg gacttgttac cgggggtctc ctaaccgtcc     1320

ttcatgttct tccagtccaa gtaccggatg tgactacttt ggaagttctg gtccctccgg     1380

taggtcgtac tcagaccgta ggacccgggg gacgacatac ccctccaccc cctgtgggac     1440

gactagtaga agttcttggt ccggtcgtcc gggatgttgt agatgggggt accgtagtga     1500

ctacactccg gggacatgtc gtcctccgac gggttccccc acttcgtgga cttcctgaag     1560

gggtaggacg gacccctcta gaagttcatg ttcacctgac actgacacct cctaccgggg     1620

tggttcagac tggggtccac ggactggtct atgatgtcgt cgaaacactt gtacctctcc     1680

ctggaccgga gaccggacta accgggggac gactagacga tgttcctcag acacctggtc     1740

tccccgttgg tctagtacag actgttctcc ttacactagg acaagagaca caaactactc     1800

ttgtcctcga ccatggactg actcttgtag gtctccaagg acgggttggg acgaccccac     1860

gtcgacctcc tgggactcaa ggtccggtcg ttgtagtacg tgtcgtagtt accgatacac     1920

aaactgtcgg acgtcgacag acacacggac gtactccacc ggatgaccat gtaggactcg     1980

taaccccggg tctgactgaa ggacagacac aagaagagac cgatgtggaa gttcgtgttc     2040

taccacatac tcctgtggga ctgggacaag gggaagagac ccctctgaca caagtactcg     2100

tacctcttgg gaccggacac ctaagacccg acggtgttga gactgaagtc cttgtccccg     2160

tactgacggg acgactttca gaggtcgaca ctgttcttgt gacccctgat gatactcctg     2220

tcgatactcc tgtagagacg gatggacgac tcgttcttgt tacggtaact cgggtcctcg     2280

aagtcggtct tgtcgtccgt ggggtcgtgg tccgtcttcg tcaagttacg gtggtggtag     2340

ggactcttac tgtatctctt ctgtctgggt accaaacggg tggcctgggg gtacgggttc     2400

taggtcttac actcgtcgag actggacgac tacgacgact ccgtctcggg gtggggggta     2460

ccggactcgg acagactgga cgtcctccgg ttcatacttt ggaagagact actggggtcg     2520

ggaccccggt aactgtcgtt gttgtcggac agactctact gggtgaagtc cggggtcgac     2580

gtggtgagac ccctgtacca caagtgggga ctcagaccgg acgtcgactc cgacttactc     2640

ttcgacccgt ggtgacgacg gtgactcgac ttcttcgacc tgaagtttca gaggtcgtgg     2700

tcgttgttgg actagtcgtg gtaggggaga ctgttggacc gacgaccgtg actgttgtgg     2760

tcgtcggacc cgggggggtc gtacggacac gtgatactgt cggtcgacct gtggtgggac     2820

aaaccgttct tctcgtcggg ggactgactc agacccccgg gggactcgga cagactcctc     2880

ttgttactgt cgttcgacga cctcagaccg gactacttgt cggtcctctc gtcgaccccg     2940

ttcttacact cgtcgtccct ctagtggtcc tggtgggacg tcagactggt cctcctctaa     3000

ctgatactac tgtggtagag acacctctac ttcttcctcc tgaaactgta gatgctgctc     3060

ctgctcttgg tctcggggtc ctcgaaggtc ttcttctggt ccgtgatgaa gtaacgacga     3120

cacctctccg acaccctgat accgtactcg tcgtcggggg tacacgactc cttgtcccgg     3180

gtcagaccga gacacggggt caagttcttc caccacaagg tcctcaagtg actaccgtcg     3240

aagtgggtcg gggacatgtc tcccctcgac ttactcgtgg acccggacga cccggggatg     3300

tagtcccgac tccacctcct gttgtagtac cactggaagt ccttggtccg gtcgtccggg     3360

atgtcgaaga tgtcgtcgga ctagtcgata ctcctcctgg tctccgtccc ccgactcggg     3420

tccttcttga aacacttcgg gttactttgg ttctggatga agaccttcca cgtcgtggtg     3480

taccgggggt ggttcctact caaactgacg ttccggaccc ggatgaagag actacacctg     3540

gacctcttcc tacacgtgag accggactaa ccgggggacg accacacggt gtggttgtgg     3600

gacttgggac gggtaccgtc cgtccactga cacgtcctca aacgggacaa gaagtggtag     3660

aaactacttt ggttctcgac catgaagtga ctcttgtacc tctccttgac gtcccggggg     3720

acgttgtagg tctacctcct ggggtggaag ttcctcttga tgtccaaggt acggtagtta     3780

ccgatgtagt acctgtggga cggaccggac cactaccggg tcctggtctc ctagtccacc     3840

atggacgact cgtacccgtc gttactcttg taggtgtcgt aggtgaagag accggtacac     3900

aagtgacact ccttcttcct cctcatgttc taccgggaca tgttggacat gggaccccac     3960

aaactctgac acctctacga cgggtcgttc cgaccgtaga cctcccacct cacggactaa     4020

cccctcgtgg acgtacgacc gtactcgtgg gacaaggacc acatgtcgtt gttcacggtc     4080

tggggggacc cgtaccggag accggtgtag tccctgaagg tctagtgacg gagaccggtc     4140

ataccggtca cccgggggtt cgaccggtcc gacgtgatga gaccgtcgta gttacggacc     4200

tcgtggttcc tcgggaagtc gacctagttc cacctggacg accgggggta ctagtaggta     4260

ccgtagttct gggtcccccg gtccgtcttc aagtcgtcgg acatgtagtc ggtcaagtag     4320

tagtacatgt cggacctacc gttcttcacc gtctggatgt ccccgttgtc gtgaccgtgg     4380

gactaccaca agaaaccgtt acacctgtcg agaccgtagt tcgtgttgta gaagttgggg     4440

gggtagtaac ggtctatgta gtccgacgtg gggtgggtga tgtcgtagtc ctcgtgggac     4500

tcctacctcg actacccgac actggacttg tcgacgtcgt acggggaccc gtacctctcg     4560

ttccggtaga gactacgggt ctagtgacgg tcgtcgatga agtggttgta caaacggtgg     4620

acctcggggt cgttccggtc cgacgtggac gtcccgtcct cgttacggac ctccggggtc     4680

cagttgttgg ggttcctcac cgacgtccac ctgaaggtct tctggtactt ccactgaccc     4740

cactggtggg tcccccactt ctcggacgac tggtcgtaca tacacttcct caaggactag     4800

tcgtcgtcgg tcctaccggt ggtcacctgg gacaagaagg tcttaccgtt ccacttccac     4860

aaggtcccgt tggtcctgtc gaagtgggga caccacttgt cggacctggg gggggacgac     4920

tggtctatgg actcctaagt gggggtctcg acccacgtgg tctaacggga ctcctacctc     4980

cacgacccga cactccgggt cctggacatg act                                  5013


<210>  16
<211>  4425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complementary strand to FVIII transgene (V3)

<400>  16
tacgtctaac tcgactcgtg gacgaagaag gacacggacg actccaagac gaagagacgg       60

tggtcctcta tgatggaccc ccgacacctc gactcgaccc tgatgtacgt cagactggac      120

cccctcgacg gacacctacg gtccaagggg gggtctcacg ggttctcgaa ggggaagttg      180

tggagacacc acatgttctt ctgggacaaa cacctcaagt gactggtgga caagttgtaa      240

cggttcgggt ccggggggac ctacccggac gacccggggt ggtaggtccg actccacata      300

ctgtgacacc actagtggga cttcttgtac cggtcggtgg gacactcgga cgtacgacac      360

ccccactcga tgaccttccg gagactcccc cgactcatac tactggtctg gtcggtctcc      420

ctcttcctcc tactgttcca caagggaccc ccgtcggtgt ggatacacac cgtccacgac      480

ttcctcttac cggggtaccg gagactgggg gacacggact ggatgtcgat ggactcggta      540

cacctggacc acttcctgga cttgagaccg gactaacccc gggacgacca cacgtccctc      600

ccgtcggacc ggttcctctt ctgggtctgg gacgtgttca agtaggacga caaacgacac      660

aaactactcc cgttctcgac cgtgagactt tggttcttgt cggactacgt cctgtcccta      720

cgacggagac ggtcccggac cgggttctac gtgtgacact taccgataca cttgtcctcg      780

gacggaccgg actaaccgac ggtgtccttc agacacatga ccgtacacta accgtacccg      840

tggtggggac tccacgtgtc gtagaaggac ctcccggtgt ggaaggacca gtccttggtg      900

tccgtccggt cggacctcta gtcggggtag tggaaggact gacgggtctg ggacgactac      960

ctggacccgg tcaaggacga caagacggtg tagtcgtcgg tggtcgtact accgtacctc     1020

cggatacact tccacctgtc gacgggactc ctcggggtcg actcctactt cttgttactc     1080

ctccgactcc tgatactact actggactga ctgagactct acctacacca ctccaaacta     1140

ctactgttgt cggggtcgaa gtaggtctag tccagacacc ggttcttcgt ggggttctgg     1200

acccacgtga tgtaacgacg actcctcctc ctgaccctga tacgggggga ccacgaccgg     1260

ggactactgt cctcgatgtt ctcggtcatg gacttgttac cgggggtctc ctaaccgtcc     1320

ttcatgttct tccagtccaa gtaccggatg tgactacttt ggaagttctg gtccctccgg     1380

taggtcgtac tcagaccgta ggacccgggg gacgacatac ccctccaccc cctgtgggac     1440

gactagtaga agttcttggt ccggtcgtcc gggatgttgt agatgggggt accgtagtga     1500

ctacactccg gggacatgtc gtcctccgac gggttccccc acttcgtgga cttcctgaag     1560

gggtaggacg gacccctcta gaagttcatg ttcacctgac actgacacct cctaccgggg     1620

tggttcagac tggggtccac ggactggtct atgatgtcgt cgaaacactt gtacctctcc     1680

ctggaccgga gaccggacta accgggggac gactagacga tgttcctcag acacctggtc     1740

tccccgttgg tctagtacag actgttctcc ttacactagg acaagagaca caaactactc     1800

ttgtcctcga ccatggactg actcttgtag gtctccaagg acgggttggg acgaccccac     1860

gtcgacctcc tgggactcaa ggtccggtcg ttgtagtacg tgtcgtagtt accgatacac     1920

aaactgtcgg acgtcgacag acacacggac gtactccacc ggatgaccat gtaggactcg     1980

taaccccggg tctgactgaa ggacagacac aagaagagac cgatgtggaa gttcgtgttc     2040

taccacatac tcctgtggga ctgggacaag gggaagagac ccctctgaca caagtactcg     2100

tacctcttgg gaccggacac ctaagacccg acggtgttga gactgaagtc cttgtccccg     2160

tactgacggg acgactttca gaggtcgaca ctgttcttgt gacccctgat gatactcctg     2220

tcgatactcc tgtagagacg gatggacgac tcgttcttgt tacggtaact cgggtcctcg     2280

aagtcggtct tacggtgatt acacagattg ttgtcgttgt ggtcgttact gtcgttacac     2340

agagggggtc acgacttctc cgtggtctcc ctctagtggt cctggtggga cgtcagactg     2400

gtcctcctct aactgatact actgtggtag agacacctct acttcttcct cctgaaactg     2460

tagatgctgc tcctgctctt ggtctcgggg tcctcgaagg tcttcttctg gtccgtgatg     2520

aagtaacgac gacacctctc cgacaccctg ataccgtact cgtcgtcggg ggtacacgac     2580

tccttgtccc gggtcagacc gagacacggg gtcaagttct tccaccacaa ggtcctcaag     2640

tgactaccgt cgaagtgggt cggggacatg tctcccctcg acttactcgt ggacccggac     2700

gacccgggga tgtagtcccg actccacctc ctgttgtagt accactggaa gtccttggtc     2760

cggtcgtccg ggatgtcgaa gatgtcgtcg gactagtcga tactcctcct ggtctccgtc     2820

ccccgactcg ggtccttctt gaaacacttc gggttacttt ggttctggat gaagaccttc     2880

cacgtcgtgg tgtaccgggg gtggttccta ctcaaactga cgttccggac ccggatgaag     2940

agactacacc tggacctctt cctacacgtg agaccggact aaccggggga cgaccacacg     3000

gtgtggttgt gggacttggg acgggtaccg tccgtccact gacacgtcct caaacgggac     3060

aagaagtggt agaaactact ttggttctcg accatgaagt gactcttgta cctctccttg     3120

acgtcccggg ggacgttgta ggtctacctc ctggggtgga agttcctctt gatgtccaag     3180

gtacggtagt taccgatgta gtacctgtgg gacggaccgg accactaccg ggtcctggtc     3240

tcctagtcca ccatggacga ctcgtacccg tcgttactct tgtaggtgtc gtaggtgaag     3300

agaccggtac acaagtgaca ctccttcttc ctcctcatgt tctaccggga catgttggac     3360

atgggacccc acaaactctg acacctctac gacgggtcgt tccgaccgta gacctcccac     3420

ctcacggact aacccctcgt ggacgtacga ccgtactcgt gggacaagga ccacatgtcg     3480

ttgttcacgg tctgggggga cccgtaccgg agaccggtgt agtccctgaa ggtctagtga     3540

cggagaccgg tcataccggt cacccggggg ttcgaccggt ccgacgtgat gagaccgtcg     3600

tagttacgga cctcgtggtt cctcgggaag tcgacctagt tccacctgga cgaccggggg     3660

tactagtagg taccgtagtt ctgggtcccc cggtccgtct tcaagtcgtc ggacatgtag     3720

tcggtcaagt agtagtacat gtcggaccta ccgttcttca ccgtctggat gtccccgttg     3780

tcgtgaccgt gggactacca caagaaaccg ttacacctgt cgagaccgta gttcgtgttg     3840

tagaagttgg gggggtagta acggtctatg tagtccgacg tggggtgggt gatgtcgtag     3900

tcctcgtggg actcctacct cgactacccg acactggact tgtcgacgtc gtacggggac     3960

ccgtacctct cgttccggta gagactacgg gtctagtgac ggtcgtcgat gaagtggttg     4020

tacaaacggt ggacctcggg gtcgttccgg tccgacgtgg acgtcccgtc ctcgttacgg     4080

acctccgggg tccagttgtt ggggttcctc accgacgtcc acctgaaggt cttctggtac     4140

ttccactgac cccactggtg ggtcccccac ttctcggacg actggtcgta catacacttc     4200

ctcaaggact agtcgtcgtc ggtcctaccg gtggtcacct gggacaagaa ggtcttaccg     4260

ttccacttcc acaaggtccc gttggtcctg tcgaagtggg gacaccactt gtcggacctg     4320

gggggggacg actggtctat ggactcctaa gtgggggtct cgacccacgt ggtctaacgg     4380

gactcctacc tccacgaccc gacactccgg gtcctggaca tgact                     4425


<210>  17
<211>  1670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII polypeptide (N6)

<400>  17

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Arg Glu Ile Thr Arg Thr Thr 
            980                 985                 990         


Leu Gln Ser Asp Gln Glu Glu Ile  Asp Tyr Asp Asp Thr  Ile Ser Val 
        995                 1000                 1005             


Glu Met  Lys Lys Glu Asp Phe  Asp Ile Tyr Asp Glu  Asp Glu Asn 
    1010                 1015                 1020             


Gln Ser  Pro Arg Ser Phe Gln  Lys Lys Thr Arg His  Tyr Phe Ile 
    1025                 1030                 1035             


Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly Met Ser  Ser Ser Pro 
    1040                 1045                 1050             


His Val  Leu Arg Asn Arg Ala  Gln Ser Gly Ser Val  Pro Gln Phe 
    1055                 1060                 1065             


Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp Gly Ser  Phe Thr Gln 
    1070                 1075                 1080             


Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His Leu Gly  Leu Leu Gly 
    1085                 1090                 1095             


Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn Ile Met  Val Thr Phe 
    1100                 1105                 1110             


Arg Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Ile 
    1115                 1120                 1125             


Ser Tyr  Glu Glu Asp Gln Arg  Gln Gly Ala Glu Pro  Arg Lys Asn 
    1130                 1135                 1140             


Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr Phe Trp  Lys Val Gln 
    1145                 1150                 1155             


His His  Met Ala Pro Thr Lys  Asp Glu Phe Asp Cys  Lys Ala Trp 
    1160                 1165                 1170             


Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys Asp Val  His Ser Gly 
    1175                 1180                 1185             


Leu Ile  Gly Pro Leu Leu Val  Cys His Thr Asn Thr  Leu Asn Pro 
    1190                 1195                 1200             


Ala His  Gly Arg Gln Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe 
    1205                 1210                 1215             


Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
    1220                 1225                 1230             


Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 
    1235                 1240                 1245             


Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile 
    1250                 1255                 1260             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 
    1265                 1270                 1275             


Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 
    1280                 1285                 1290             


Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 
    1295                 1300                 1305             


Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 
    1310                 1315                 1320             


Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 
    1325                 1330                 1335             


Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 
    1340                 1345                 1350             


Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly 
    1355                 1360                 1365             


His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    1370                 1375                 1380             


Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 
    1385                 1390                 1395             


Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    1400                 1405                 1410             


Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    1415                 1420                 1425             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 
    1430                 1435                 1440             


Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 
    1445                 1450                 1455             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 
    1460                 1465                 1470             


Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    1475                 1480                 1485             


Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 
    1490                 1495                 1500             


Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    1505                 1510                 1515             


Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    1520                 1525                 1530             


Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu 
    1535                 1540                 1545             


His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn 
    1550                 1555                 1560             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 
    1565                 1570                 1575             


Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 
    1580                 1585                 1590             


Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln 
    1595                 1600                 1605             


Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 
    1610                 1615                 1620             


Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    1625                 1630                 1635             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 
    1640                 1645                 1650             


Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp 
    1655                 1660                 1665             


Leu Tyr  
    1670 


<210>  18
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII polypeptide (V3)

<400>  18

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ala Thr Asn Val 
        755                 760                 765             


Ser Asn Asn Ser Asn Thr Ser Asn Asp Ser Asn Val Ser Pro Pro Val 
    770                 775                 780                 


Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp 
785                 790                 795                 800 


Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys 
                805                 810                 815     


Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser 
            820                 825                 830         


Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu 
        835                 840                 845             


Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala 
    850                 855                 860                 


Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe 
865                 870                 875                 880 


Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu 
                885                 890                 895     


His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn 
            900                 905                 910         


Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr 
        915                 920                 925             


Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro 
    930                 935                 940                 


Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys 
945                 950                 955                 960 


Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
                965                 970                 975     


Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 
            980                 985                 990         


Leu Ile Gly Pro Leu Leu Val Cys  His Thr Asn Thr Leu  Asn Pro Ala 
        995                 1000                 1005             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1010                 1015                 1020             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 
    1025                 1030                 1035             


Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 
    1040                 1045                 1050             


Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Ile Met 
    1055                 1060                 1065             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 
    1070                 1075                 1080             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1085                 1090                 1095             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 
    1100                 1105                 1110             


Lys Met  Ala Leu Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    1115                 1120                 1125             


Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 
    1130                 1135                 1140             


Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    1145                 1150                 1155             


Tyr Ser  Asn Lys Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 
    1160                 1165                 1170             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    1175                 1180                 1185             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    1190                 1195                 1200             


Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 
    1205                 1210                 1215             


Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 
    1220                 1225                 1230             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    1235                 1240                 1245             


Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 
    1250                 1255                 1260             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 
    1265                 1270                 1275             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    1280                 1285                 1290             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    1295                 1300                 1305             


Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 
    1310                 1315                 1320             


Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 
    1325                 1330                 1335             


Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Lys Ala  Arg Leu His 
    1340                 1345                 1350             


Leu Gln  Gly Arg Ser Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    1355                 1360                 1365             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 
    1370                 1375                 1380             


Gly Val  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    1385                 1390                 1395             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His Gln Trp 
    1400                 1405                 1410             


Thr Leu  Phe Phe Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    1415                 1420                 1425             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 
    1430                 1435                 1440             


Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 
    1445                 1450                 1455             


Ile Ala  Leu Arg Met Glu Val  Leu Gly Cys Glu Ala  Gln Asp Leu 
    1460                 1465                 1470             


Tyr 
    


<210>  19
<211>  1080
<212>  DNA
<213>  Homo sapiens

<400>  19
atgaaggcca ctatcatcct ccttctgctt gcacaagttt cctgggctgg accgtttcaa       60

cagagaggct tatttgactt tatgctagaa gatgaggctt ctgggatagg cccagaagtt      120

cctgatgacc gcgacttcga gccctcccta ggcccagtgt gccccttccg ctgtcaatgc      180

catcttcgag tggtccagtg ttctgatttg ggtctggaca aagtgccaaa ggatcttccc      240

cctgacacaa ctctgctaga cctgcaaaac aacaaaataa ccgaaatcaa agatggagac      300

tttaagaacc tgaagaacct tcacgcattg attcttgtca acaataaaat tagcaaagtt      360

agtcctggag catttacacc tttggtgaag ttggaacgac tttatctgtc caagaatcag      420

ctgaaggaat tgccagaaaa aatgcccaaa actcttcagg agctgcgtgc ccatgagaat      480

gagatcacca aagtgcgaaa agttactttc aatggactga accagatgat tgtcatagaa      540

ctgggcacca atccgctgaa gagctcagga attgaaaatg gggctttcca gggaatgaag      600

aagctctcct acatccgcat tgctgatacc aatatcacca gcattcctca aggtcttcct      660

ccttccctta cggaattaca tcttgatggc aacaaaatca gcagagttga tgcagctagc      720

ctgaaaggac tgaataattt ggctaagttg ggattgagtt tcaacagcat ctctgctgtt      780

gacaatggct ctctggccaa cacgcctcat ctgagggagc ttcacttgga caacaacaag      840

cttaccagag tacctggtgg gctggcagag cataagtaca tccaggttgt ctaccttcat      900

aacaacaata tctctgtagt tggatcaagt gacttctgcc cacctggaca caacaccaaa      960

aaggcttctt attcgggtgt gagtcttttc agcaacccgg tccagtactg ggagatacag     1020

ccatccacct tcagatgtgt ctacgtgcgc tctgccattc aactcggaaa ctataagtaa     1080


<210>  20
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  21
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  21
atgtcggctg cgcccggcct cctgcaccag gagctgtcct gcccgctgtg cctgcagctg       60

ttcgacgcgc ccgtgacagc cgagtgcggc cacagtttct gccgcgcctg cctaggccgc      120

gtggccgggg agccggcggc ggatggcacc gttctctgcc cctgctgcca ggcccccacg      180

cggccgcagg cactcagcac caacctgcag ctggcgcgcc tggtggaggg gctggcccag      240

gtgccgcagg gccactgcga ggagcacctg gacccgctga gcatctactg cgagcaggac      300

cgcgcgctgg tgtgcggagt gtgcgcctca ctcggctcgc accgcggtca tcgcctcctg      360

cctgccgccg aggcccacgc acgcctcaag acacagctgc cacagcagaa actgcagctg      420

caggaggcat gcatgcgcaa ggagaagagt gtggctgtgc tggagcatca gctggtggag      480

gtggaggaga cagtgcgtca gttccggggg gccgtggggg agcagctggg caagatgcgg      540

gtgttcctgg ctgcactgga gggctccttg gaccgcgagg cagagcgtgt acggggtgag      600

gcaggggtcg ccttgcgccg ggagctgggg agcctgaact cttacctgga gcagctgcgg      660

cagatggaga aggtcctgga ggaggtggcg gacaagccgc agactgagtt cctcatgaaa      720

tactgcctgg tgaccagcag gctgcagaag atcctggcag agtctccccc acccgcccgt      780

ctggacatcc agctgccaat tatctcagat gacttcaaat tccaggtgtg gaggaagatg      840

ttccgggctc tgatgccagc gctggaggag ctgacctttg acccgagctc tgcgcacccg      900

agcctggtgg tgtcttcctc tggccgccgc gtggagtgct cggagcagaa ggcgccgccg      960

gccggggagg acccgcgcca gttcgacaag gcggtggcgg tggtggcgca ccagcagctc     1020

tccgagggcg agcactactg ggaggtggat gttggcgaca agccgcgctg ggcgctgggc     1080

gtgatcgcgg ccgaggcccc ccgccgcggg cgcctgcacg cggtgccctc gcagggcctg     1140

tggctgctgg ggctgcgcga gggcaagatc ctggaggcac acgtggaggc caaggagccg     1200

cgcgctctgc gcagccccga gaggcggccc acgcgcattg gcctttacct gagcttcggc     1260

gacggcgtcc tctccttcta cgatgccagc gacgccgacg cgctcgtgcc gctttttgcc     1320

ttccacgagc gcctgcccag gcccgtgtac cccttcttcg acgtgtgctg gcacgacaag     1380

ggcaagaatg cccagccgct gctgctcgtg ggtcccgaag gcgccgaggc ctga           1434


<210>  22
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  23
<211>  5115
<212>  DNA
<213>  Homo sapiens

<400>  23
atggctgtgc tcaggcagct ggcgctcctc ctctggaaga actacaccct gcagaagcgg       60

aaggtcctgg tgacggtcct ggaactcttc ctgccattgc tgttttctgg gatcctcatc      120

tggctccgct tgaagattca gtcggaaaat gtgcccaacg ccaccatcta cccgggccag      180

tccatccagg agctgcctct gttcttcacc ttccctccgc caggagacac ctgggagctt      240

gcctacatcc cttctcacag tgacgctgcc aagaccgtca ctgagacagt gcgcagggca      300

cttgtgatca acatgcgagt gcgcggcttt ccctccgaga aggactttga ggactacatt      360

aggtacgaca actgctcgtc cagcgtgctg gccgccgtgg tcttcgagca ccccttcaac      420

cacagcaagg agcccctgcc gctggcggtg aaatatcacc tacggttcag ttacacacgg      480

agaaattaca tgtggaccca aacaggctcc tttttcctga aagagacaga aggctggcac      540

actacttccc ttttcccgct tttcccaaac ccaggaccaa gggaacctac atcccctgat      600

ggcggagaac ctgggtacat ccgggaaggc ttcctggccg tgcagcatgc tgtggaccgg      660

gccatcatgg agtaccatgc cgatgccgcc acacgccagc tgttccagag actgacggtg      720

accatcaaga ggttcccgta cccgccgttc atcgcagacc ccttcctcgt ggccatccag      780

taccagctgc ccctgctgct gctgctcagc ttcacctaca ccgcgctcac cattgcccgt      840

gctgtcgtgc aggagaagga aaggaggctg aaggagtaca tgcgcatgat ggggctcagc      900

agctggctgc actggagtgc ctggttcctc ttgttcttcc tcttcctcct catcgccgcc      960

tccttcatga ccctgctctt ctgtgtcaag gtgaagccaa atgtagccgt gctgtcccgc     1020

agcgacccct ccctggtgct cgccttcctg ctgtgcttcg ccatctctac catctccttc     1080

agcttcatgg tcagcacctt cttcagcaaa gccaacatgg cagcagcctt cggaggcttc     1140

ctctacttct tcacctacat cccctacttc ttcgtggccc ctcggtacaa ctggatgact     1200

ctgagccaga agctctgctc ctgcctcctg tctaatgtcg ccatggcaat gggagcccag     1260

ctcattggga aatttgaggc gaaaggcatg ggcatccagt ggcgagacct cctgagtccc     1320

gtcaacgtgg acgacgactt ctgcttcggg caggtgctgg ggatgctgct gctggactct     1380

gtgctctatg gcctggtgac ctggtacatg gaggccgtct tcccagggca gttcggcgtg     1440

cctcagccct ggtacttctt catcatgccc tcctattggt gtgggaagcc aagggcggtt     1500

gcagggaagg aggaagaaga cagtgacccc gagaaagcac tcagaaacga gtactttgaa     1560

gccgagccag aggacctggt ggcggggatc aagatcaagc acctgtccaa ggtgttcagg     1620

gtgggaaata aggacagggc ggccgtcaga gacctgaacc tcaacctgta cgagggacag     1680

atcaccgtcc tgctgggcca caacggtgcc gggaagacca ccaccctctc catgctcaca     1740

ggtctctttc cccccaccag tggacgggca tacatcagcg ggtatgaaat ttcccaggac     1800

atggttcaga tccggaagag cctgggcctg tgcccgcagc acgacatcct gtttgacaac     1860

ttgacagtcg cagagcacct ttatttctac gcccagctga agggcctgtc acgtcagaag     1920

tgccctgaag aagtcaagca gatgctgcac atcatcggcc tggaggacaa gtggaactca     1980

cggagccgct tcctgagcgg gggcatgagg cgcaagctct ccatcggcat cgccctcatc     2040

gcaggctcca aggtgctgat actggacgag cccacctcgg gcatggacgc catctccagg     2100

agggccatct gggatcttct tcagcggcag aaaagtgacc gcaccatcgt gctgaccacc     2160

cacttcatgg acgaggctga cctgctggga gaccgcatcg ccatcatggc caagggggag     2220

ctgcagtgct gcgggtcctc gctgttcctc aagcagaaat acggtgccgg ctatcacatg     2280

acgctggtga aggagccgca ctgcaacccg gaagacatct cccagctggt ccaccaccac     2340

gtgcccaacg ccacgctgga gagcagcgct ggggccgagc tgtctttcat ccttcccaga     2400

gagagcacgc acaggtttga aggtctcttt gctaaactgg agaagaagca gaaagagctg     2460

ggcattgcca gctttggggc atccatcacc accatggagg aagtcttcct tcgggtcggg     2520

aagctggtgg acagcagtat ggacatccag gccatccagc tccctgccct gcagtaccag     2580

cacgagaggc gcgccagcga ctgggctgtg gacagcaacc tctgtggggc catggacccc     2640

tccgacggca ttggagccct catcgaggag gagcgcaccg ctgtcaagct caacactggg     2700

ctcgccctgc actgccagca attctgggcc atgttcctga agaaggccgc atacagctgg     2760

cgcgagtgga aaatggtggc ggcacaggtc ctggtgcctc tgacctgcgt caccctggcc     2820

ctcctggcca tcaactactc ctcggagctc ttcgacgacc ccatgctgag gctgaccttg     2880

ggcgagtacg gcagaaccgt cgtgcccttc tcagttcccg ggacctccca gctgggtcag     2940

cagctgtcag agcatctgaa agacgcactg caggctgagg gacaggagcc ccgcgaggtg     3000

ctcggtgacc tggaggagtt cttgatcttc agggcttctg tggagggggg cggctttaat     3060

gagcggtgcc ttgtggcagc gtccttcaga gatgtgggag agcgcacggt cgtcaacgcc     3120

ttgttcaaca accaggcgta ccactctcca gccactgccc tggccgtcgt ggacaacctt     3180

ctgttcaagc tgctgtgcgg gcctcacgcc tccattgtgg tctccaactt cccccagccc     3240

cggagcgccc tgcaggctgc caaggaccag tttaacgagg gccggaaggg attcgacatt     3300

gccctcaacc tgctcttcgc catggcattc ttggccagca cgttctccat cctggcggtc     3360

agcgagaggg ccgtgcaggc caagcatgtg cagtttgtga gtggagtcca cgtggccagt     3420

ttctggctct ctgctctgct gtgggacctc atctccttcc tcatccccag tctgctgctg     3480

ctggtggtgt ttaaggcctt cgacgtgcgt gccttcacgc gggacggcca catggctgac     3540

accctgctgc tgctcctgct ctacggctgg gccatcatcc ccctcatgta cctgatgaac     3600

ttcttcttct tgggggcggc cactgcctac acgaggctga ccatcttcaa catcctgtca     3660

ggcatcgcca ccttcctgat ggtcaccatc atgcgcatcc cagctgtaaa actggaagaa     3720

ctttccaaaa ccctggatca cgtgttcctg gtgctgccca accactgtct ggggatggca     3780

gtcagcagtt tctacgagaa ctacgagacg cggaggtact gcacctcctc cgaggtcgcc     3840

gcccactact gcaagaaata taacatccag taccaggaga acttctatgc ctggagcgcc     3900

ccgggggtcg gccggtttgt ggcctccatg gccgcctcag ggtgcgccta cctcatcctg     3960

ctcttcctca tcgagaccaa cctgcttcag agactcaggg gcatcctctg cgccctccgg     4020

aggaggcgga cactgacaga attatacacc cggatgcctg tgcttcctga ggaccaagat     4080

gtagcggacg agaggacccg catcctggcc cccagtccgg actccctgct ccacacacct     4140

ctgattatca aggagctctc caaggtgtac gagcagcggg tgcccctcct ggccgtggac     4200

aggctctccc tcgcggtgca gaaaggggag tgcttcggcc tgctgggctt caatggagcc     4260

gggaagacca cgactttcaa aatgctgacc ggggaggaga gcctcacttc tggggatgcc     4320

tttgtcgggg gtcacagaat cagctctgat gtcggaaagg tgcggcagcg gatcggctac     4380

tgcccgcagt ttgatgcctt gctggaccac atgacaggcc gggagatgct ggtcatgtac     4440

gctcggctcc ggggcatccc tgagcgccac atcggggcct gcgtggagaa cactctgcgg     4500

ggcctgctgc tggagccaca tgccaacaag ctggtcagga cgtacagtgg tggtaacaag     4560

cggaagctga gcaccggcat cgccctgatc ggagagcctg ctgtcatctt cctggacgag     4620

ccgtccactg gcatggaccc cgtggcccgg cgcctgcttt gggacaccgt ggcacgagcc     4680

cgagagtctg gcaaggccat catcatcacc tcccacagca tggaggagtg tgaggccctg     4740

tgcacccggc tggccatcat ggtgcagggg cagttcaagt gcctgggcag cccccagcac     4800

ctcaagagca agttcggcag cggctactcc ctgcgggcca aggtgcagag tgaagggcaa     4860

caggaggcgc tggaggagtt caaggccttc gtggacctga cctttccagg cagcgtcctg     4920

gaagatgagc accaaggcat ggtccattac cacctgccgg gccgtgacct cagctgggcg     4980

aaggttttcg gtattctgga gaaagccaag gaaaagtacg gcgtggacga ctactccgtg     5040

agccagatct cgctggaaca ggtcttcctg agcttcgccc acctgcagcc gcccaccgca     5100

gaggaggggc gatga                                                      5115


<210>  24
<211>  1704
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Val Leu Arg Gln Leu Ala Leu Leu Leu Trp Lys Asn Tyr Thr 
1               5                   10                  15      


Leu Gln Lys Arg Lys Val Leu Val Thr Val Leu Glu Leu Phe Leu Pro 
            20                  25                  30          


Leu Leu Phe Ser Gly Ile Leu Ile Trp Leu Arg Leu Lys Ile Gln Ser 
        35                  40                  45              


Glu Asn Val Pro Asn Ala Thr Ile Tyr Pro Gly Gln Ser Ile Gln Glu 
    50                  55                  60                  


Leu Pro Leu Phe Phe Thr Phe Pro Pro Pro Gly Asp Thr Trp Glu Leu 
65                  70                  75                  80  


Ala Tyr Ile Pro Ser His Ser Asp Ala Ala Lys Thr Val Thr Glu Thr 
                85                  90                  95      


Val Arg Arg Ala Leu Val Ile Asn Met Arg Val Arg Gly Phe Pro Ser 
            100                 105                 110         


Glu Lys Asp Phe Glu Asp Tyr Ile Arg Tyr Asp Asn Cys Ser Ser Ser 
        115                 120                 125             


Val Leu Ala Ala Val Val Phe Glu His Pro Phe Asn His Ser Lys Glu 
    130                 135                 140                 


Pro Leu Pro Leu Ala Val Lys Tyr His Leu Arg Phe Ser Tyr Thr Arg 
145                 150                 155                 160 


Arg Asn Tyr Met Trp Thr Gln Thr Gly Ser Phe Phe Leu Lys Glu Thr 
                165                 170                 175     


Glu Gly Trp His Thr Thr Ser Leu Phe Pro Leu Phe Pro Asn Pro Gly 
            180                 185                 190         


Pro Arg Glu Pro Thr Ser Pro Asp Gly Gly Glu Pro Gly Tyr Ile Arg 
        195                 200                 205             


Glu Gly Phe Leu Ala Val Gln His Ala Val Asp Arg Ala Ile Met Glu 
    210                 215                 220                 


Tyr His Ala Asp Ala Ala Thr Arg Gln Leu Phe Gln Arg Leu Thr Val 
225                 230                 235                 240 


Thr Ile Lys Arg Phe Pro Tyr Pro Pro Phe Ile Ala Asp Pro Phe Leu 
                245                 250                 255     


Val Ala Ile Gln Tyr Gln Leu Pro Leu Leu Leu Leu Leu Ser Phe Thr 
            260                 265                 270         


Tyr Thr Ala Leu Thr Ile Ala Arg Ala Val Val Gln Glu Lys Glu Arg 
        275                 280                 285             


Arg Leu Lys Glu Tyr Met Arg Met Met Gly Leu Ser Ser Trp Leu His 
    290                 295                 300                 


Trp Ser Ala Trp Phe Leu Leu Phe Phe Leu Phe Leu Leu Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Met Thr Leu Leu Phe Cys Val Lys Val Lys Pro Asn Val Ala 
                325                 330                 335     


Val Leu Ser Arg Ser Asp Pro Ser Leu Val Leu Ala Phe Leu Leu Cys 
            340                 345                 350         


Phe Ala Ile Ser Thr Ile Ser Phe Ser Phe Met Val Ser Thr Phe Phe 
        355                 360                 365             


Ser Lys Ala Asn Met Ala Ala Ala Phe Gly Gly Phe Leu Tyr Phe Phe 
    370                 375                 380                 


Thr Tyr Ile Pro Tyr Phe Phe Val Ala Pro Arg Tyr Asn Trp Met Thr 
385                 390                 395                 400 


Leu Ser Gln Lys Leu Cys Ser Cys Leu Leu Ser Asn Val Ala Met Ala 
                405                 410                 415     


Met Gly Ala Gln Leu Ile Gly Lys Phe Glu Ala Lys Gly Met Gly Ile 
            420                 425                 430         


Gln Trp Arg Asp Leu Leu Ser Pro Val Asn Val Asp Asp Asp Phe Cys 
        435                 440                 445             


Phe Gly Gln Val Leu Gly Met Leu Leu Leu Asp Ser Val Leu Tyr Gly 
    450                 455                 460                 


Leu Val Thr Trp Tyr Met Glu Ala Val Phe Pro Gly Gln Phe Gly Val 
465                 470                 475                 480 


Pro Gln Pro Trp Tyr Phe Phe Ile Met Pro Ser Tyr Trp Cys Gly Lys 
                485                 490                 495     


Pro Arg Ala Val Ala Gly Lys Glu Glu Glu Asp Ser Asp Pro Glu Lys 
            500                 505                 510         


Ala Leu Arg Asn Glu Tyr Phe Glu Ala Glu Pro Glu Asp Leu Val Ala 
        515                 520                 525             


Gly Ile Lys Ile Lys His Leu Ser Lys Val Phe Arg Val Gly Asn Lys 
    530                 535                 540                 


Asp Arg Ala Ala Val Arg Asp Leu Asn Leu Asn Leu Tyr Glu Gly Gln 
545                 550                 555                 560 


Ile Thr Val Leu Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu 
                565                 570                 575     


Ser Met Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Arg Ala Tyr Ile 
            580                 585                 590         


Ser Gly Tyr Glu Ile Ser Gln Asp Met Val Gln Ile Arg Lys Ser Leu 
        595                 600                 605             


Gly Leu Cys Pro Gln His Asp Ile Leu Phe Asp Asn Leu Thr Val Ala 
    610                 615                 620                 


Glu His Leu Tyr Phe Tyr Ala Gln Leu Lys Gly Leu Ser Arg Gln Lys 
625                 630                 635                 640 


Cys Pro Glu Glu Val Lys Gln Met Leu His Ile Ile Gly Leu Glu Asp 
                645                 650                 655     


Lys Trp Asn Ser Arg Ser Arg Phe Leu Ser Gly Gly Met Arg Arg Lys 
            660                 665                 670         


Leu Ser Ile Gly Ile Ala Leu Ile Ala Gly Ser Lys Val Leu Ile Leu 
        675                 680                 685             


Asp Glu Pro Thr Ser Gly Met Asp Ala Ile Ser Arg Arg Ala Ile Trp 
    690                 695                 700                 


Asp Leu Leu Gln Arg Gln Lys Ser Asp Arg Thr Ile Val Leu Thr Thr 
705                 710                 715                 720 


His Phe Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Met 
                725                 730                 735     


Ala Lys Gly Glu Leu Gln Cys Cys Gly Ser Ser Leu Phe Leu Lys Gln 
            740                 745                 750         


Lys Tyr Gly Ala Gly Tyr His Met Thr Leu Val Lys Glu Pro His Cys 
        755                 760                 765             


Asn Pro Glu Asp Ile Ser Gln Leu Val His His His Val Pro Asn Ala 
    770                 775                 780                 


Thr Leu Glu Ser Ser Ala Gly Ala Glu Leu Ser Phe Ile Leu Pro Arg 
785                 790                 795                 800 


Glu Ser Thr His Arg Phe Glu Gly Leu Phe Ala Lys Leu Glu Lys Lys 
                805                 810                 815     


Gln Lys Glu Leu Gly Ile Ala Ser Phe Gly Ala Ser Ile Thr Thr Met 
            820                 825                 830         


Glu Glu Val Phe Leu Arg Val Gly Lys Leu Val Asp Ser Ser Met Asp 
        835                 840                 845             


Ile Gln Ala Ile Gln Leu Pro Ala Leu Gln Tyr Gln His Glu Arg Arg 
    850                 855                 860                 


Ala Ser Asp Trp Ala Val Asp Ser Asn Leu Cys Gly Ala Met Asp Pro 
865                 870                 875                 880 


Ser Asp Gly Ile Gly Ala Leu Ile Glu Glu Glu Arg Thr Ala Val Lys 
                885                 890                 895     


Leu Asn Thr Gly Leu Ala Leu His Cys Gln Gln Phe Trp Ala Met Phe 
            900                 905                 910         


Leu Lys Lys Ala Ala Tyr Ser Trp Arg Glu Trp Lys Met Val Ala Ala 
        915                 920                 925             


Gln Val Leu Val Pro Leu Thr Cys Val Thr Leu Ala Leu Leu Ala Ile 
    930                 935                 940                 


Asn Tyr Ser Ser Glu Leu Phe Asp Asp Pro Met Leu Arg Leu Thr Leu 
945                 950                 955                 960 


Gly Glu Tyr Gly Arg Thr Val Val Pro Phe Ser Val Pro Gly Thr Ser 
                965                 970                 975     


Gln Leu Gly Gln Gln Leu Ser Glu His Leu Lys Asp Ala Leu Gln Ala 
            980                 985                 990         


Glu Gly Gln Glu Pro Arg Glu Val  Leu Gly Asp Leu Glu  Glu Phe Leu 
        995                 1000                 1005             


Ile Phe  Arg Ala Ser Val Glu  Gly Gly Gly Phe Asn  Glu Arg Cys 
    1010                 1015                 1020             


Leu Val  Ala Ala Ser Phe Arg  Asp Val Gly Glu Arg  Thr Val Val 
    1025                 1030                 1035             


Asn Ala  Leu Phe Asn Asn Gln  Ala Tyr His Ser Pro  Ala Thr Ala 
    1040                 1045                 1050             


Leu Ala  Val Val Asp Asn Leu  Leu Phe Lys Leu Leu  Cys Gly Pro 
    1055                 1060                 1065             


His Ala  Ser Ile Val Val Ser  Asn Phe Pro Gln Pro  Arg Ser Ala 
    1070                 1075                 1080             


Leu Gln  Ala Ala Lys Asp Gln  Phe Asn Glu Gly Arg  Lys Gly Phe 
    1085                 1090                 1095             


Asp Ile  Ala Leu Asn Leu Leu  Phe Ala Met Ala Phe  Leu Ala Ser 
    1100                 1105                 1110             


Thr Phe  Ser Ile Leu Ala Val  Ser Glu Arg Ala Val  Gln Ala Lys 
    1115                 1120                 1125             


His Val  Gln Phe Val Ser Gly  Val His Val Ala Ser  Phe Trp Leu 
    1130                 1135                 1140             


Ser Ala  Leu Leu Trp Asp Leu  Ile Ser Phe Leu Ile  Pro Ser Leu 
    1145                 1150                 1155             


Leu Leu  Leu Val Val Phe Lys  Ala Phe Asp Val Arg  Ala Phe Thr 
    1160                 1165                 1170             


Arg Asp  Gly His Met Ala Asp  Thr Leu Leu Leu Leu  Leu Leu Tyr 
    1175                 1180                 1185             


Gly Trp  Ala Ile Ile Pro Leu  Met Tyr Leu Met Asn  Phe Phe Phe 
    1190                 1195                 1200             


Leu Gly  Ala Ala Thr Ala Tyr  Thr Arg Leu Thr Ile  Phe Asn Ile 
    1205                 1210                 1215             


Leu Ser  Gly Ile Ala Thr Phe  Leu Met Val Thr Ile  Met Arg Ile 
    1220                 1225                 1230             


Pro Ala  Val Lys Leu Glu Glu  Leu Ser Lys Thr Leu  Asp His Val 
    1235                 1240                 1245             


Phe Leu  Val Leu Pro Asn His  Cys Leu Gly Met Ala  Val Ser Ser 
    1250                 1255                 1260             


Phe Tyr  Glu Asn Tyr Glu Thr  Arg Arg Tyr Cys Thr  Ser Ser Glu 
    1265                 1270                 1275             


Val Ala  Ala His Tyr Cys Lys  Lys Tyr Asn Ile Gln  Tyr Gln Glu 
    1280                 1285                 1290             


Asn Phe  Tyr Ala Trp Ser Ala  Pro Gly Val Gly Arg  Phe Val Ala 
    1295                 1300                 1305             


Ser Met  Ala Ala Ser Gly Cys  Ala Tyr Leu Ile Leu  Leu Phe Leu 
    1310                 1315                 1320             


Ile Glu  Thr Asn Leu Leu Gln  Arg Leu Arg Gly Ile  Leu Cys Ala 
    1325                 1330                 1335             


Leu Arg  Arg Arg Arg Thr Leu  Thr Glu Leu Tyr Thr  Arg Met Pro 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Gln Asp  Val Ala Asp Glu Arg  Thr Arg Ile 
    1355                 1360                 1365             


Leu Ala  Pro Ser Pro Asp Ser  Leu Leu His Thr Pro  Leu Ile Ile 
    1370                 1375                 1380             


Lys Glu  Leu Ser Lys Val Tyr  Glu Gln Arg Val Pro  Leu Leu Ala 
    1385                 1390                 1395             


Val Asp  Arg Leu Ser Leu Ala  Val Gln Lys Gly Glu  Cys Phe Gly 
    1400                 1405                 1410             


Leu Leu  Gly Phe Asn Gly Ala  Gly Lys Thr Thr Thr  Phe Lys Met 
    1415                 1420                 1425             


Leu Thr  Gly Glu Glu Ser Leu  Thr Ser Gly Asp Ala  Phe Val Gly 
    1430                 1435                 1440             


Gly His  Arg Ile Ser Ser Asp  Val Gly Lys Val Arg  Gln Arg Ile 
    1445                 1450                 1455             


Gly Tyr  Cys Pro Gln Phe Asp  Ala Leu Leu Asp His  Met Thr Gly 
    1460                 1465                 1470             


Arg Glu  Met Leu Val Met Tyr  Ala Arg Leu Arg Gly  Ile Pro Glu 
    1475                 1480                 1485             


Arg His  Ile Gly Ala Cys Val  Glu Asn Thr Leu Arg  Gly Leu Leu 
    1490                 1495                 1500             


Leu Glu  Pro His Ala Asn Lys  Leu Val Arg Thr Tyr  Ser Gly Gly 
    1505                 1510                 1515             


Asn Lys  Arg Lys Leu Ser Thr  Gly Ile Ala Leu Ile  Gly Glu Pro 
    1520                 1525                 1530             


Ala Val  Ile Phe Leu Asp Glu  Pro Ser Thr Gly Met  Asp Pro Val 
    1535                 1540                 1545             


Ala Arg  Arg Leu Leu Trp Asp  Thr Val Ala Arg Ala  Arg Glu Ser 
    1550                 1555                 1560             


Gly Lys  Ala Ile Ile Ile Thr  Ser His Ser Met Glu  Glu Cys Glu 
    1565                 1570                 1575             


Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val Gln Gly  Gln Phe Lys 
    1580                 1585                 1590             


Cys Leu  Gly Ser Pro Gln His  Leu Lys Ser Lys Phe  Gly Ser Gly 
    1595                 1600                 1605             


Tyr Ser  Leu Arg Ala Lys Val  Gln Ser Glu Gly Gln  Gln Glu Ala 
    1610                 1615                 1620             


Leu Glu  Glu Phe Lys Ala Phe  Val Asp Leu Thr Phe  Pro Gly Ser 
    1625                 1630                 1635             


Val Leu  Glu Asp Glu His Gln  Gly Met Val His Tyr  His Leu Pro 
    1640                 1645                 1650             


Gly Arg  Asp Leu Ser Trp Ala  Lys Val Phe Gly Ile  Leu Glu Lys 
    1655                 1660                 1665             


Ala Lys  Glu Lys Tyr Gly Val  Asp Asp Tyr Ser Val  Ser Gln Ile 
    1670                 1675                 1680             


Ser Leu  Glu Gln Val Phe Leu  Ser Phe Ala His Leu  Gln Pro Pro 
    1685                 1690                 1695             


Thr Ala  Glu Glu Gly Arg 
    1700                 


<210>  25
<211>  3117
<212>  DNA
<213>  Homo sapiens

<400>  25
atgacttcct cgctgcagcg gccctggcgg gtgccctggc taccatggac catcctgctg       60

gtcagcactg cggctgcttc gcagaatcaa gaacggctat gtgcgtttaa agatccgtat      120

cagcaagacc ttgggatagg tgagagtaga atctctcatg aaaatgggac aatattatgc      180

tcgaaaggta gcacctgcta tggcctttgg gagaaatcaa aaggggacat aaatcttgta      240

aaacaaggat gttggtctca cattggagat ccccaagagt gtcactatga agaatgtgta      300

gtaactacca ctcctccctc aattcagaat ggaacatacc gtttctgctg ttgtagcaca      360

gatttatgta atgtcaactt tactgagaat tttccacctc ctgacacaac accactcagt      420

ccacctcatt catttaaccg agatgagaca ataatcattg ctttggcatc agtctctgta      480

ttagctgttt tgatagttgc cttatgcttt ggatacagaa tgttgacagg agaccgtaaa      540

caaggtcttc acagtatgaa catgatggag gcagcagcat ccgaaccctc tcttgatcta      600

gataatctga aactgttgga gctgattggc cgaggtcgat atggagcagt atataaaggc      660

tccttggatg agcgtccagt tgctgtaaaa gtgttttcct ttgcaaaccg tcagaatttt      720

atcaacgaaa agaacattta cagagtgcct ttgatggaac atgacaacat tgcccgcttt      780

atagttggag atgagagagt cactgcagat ggacgcatgg aatatttgct tgtgatggag      840

tactatccca atggatcttt atgcaagtat ttaagtctcc acacaagtga ctgggtaagc      900

tcttgccgtc ttgctcattc tgttactaga ggactggctt atcttcacac agaattacca      960

cgaggagatc attataaacc tgcaatttcc catcgagatt taaacagcag aaatgtccta     1020

gtgaaaaatg atggaacctg tgttattagt gactttggac tgtccatgag gctgactgga     1080

aatagactgg tgcgcccagg ggaggaagat aatgcagcca taagcgaggt tggcactatc     1140

agatatatgg caccagaagt gctagaagga gctgtgaact tgagggactg tgaatcagct     1200

ttgaaacaag tagacatgta tgctcttgga ctaatctatt gggagatatt tatgagatgt     1260

acagacctct tcccagggga atccgtacca gagtaccaga tggcttttca gacagaggtt     1320

ggaaaccatc ccacttttga ggatatgcag gttctcgtgt ctagggaaaa acagagaccc     1380

aagttcccag aagcctggaa agaaaatagc ctggcagtga ggtcactcaa ggagacaatc     1440

gaagactgtt gggaccagga tgcagaggct cggcttactg cacagtgtgc tgaggaaagg     1500

atggctgaac ttatgatgat ttgggaaaga aacaaatctg tgagcccaac agtcaatcca     1560

atgtctactg ctatgcagaa tgaacgcaac ctgtcacata ataggcgtgt gccaaaaatt     1620

ggtccttatc cagattattc ttcctcctca tacattgaag actctatcca tcatactgac     1680

agcatcgtga agaatatttc ctctgagcat tctatgtcca gcacaccttt gactataggg     1740

gaaaaaaacc gaaattcaat taactatgaa cgacagcaag cacaagctcg aatccccagc     1800

cctgaaacaa gtgtcaccag cctctccacc aacacaacaa ccacaaacac cacaggactc     1860

acgccaagta ctggcatgac tactatatct gagatgccat acccagatga aacaaatctg     1920

cataccacaa atgttgcaca gtcaattggg ccaacccctg tctgcttaca gctgacagaa     1980

gaagacttgg aaaccaacaa gctagaccca aaagaagttg ataagaacct caaggaaagc     2040

tctgatgaga atctcatgga gcactctctt aaacagttca gtggcccaga cccactgagc     2100

agtactagtt ctagcttgct ttacccactc ataaaacttg cagtagaagc aactggacag     2160

caggacttca cacagactgc aaatggccaa gcatgtttga ttcctgatgt tctgcctact     2220

cagatctatc ctctccccaa gcagcagaac cttcccaaga gacctactag tttgcctttg     2280

aacaccaaaa attcaacaaa agagccccgg ctaaaatttg gcagcaagca caaatcaaac     2340

ttgaaacaag tcgaaactgg agttgccaag atgaatacaa tcaatgcagc agaacctcat     2400

gtggtgacag tcaccatgaa tggtgtggca ggtagaaacc acagtgttaa ctcccatgct     2460

gccacaaccc aatatgccaa tgggacagta ctatctggcc aaacaaccaa catagtgaca     2520

catagggccc aagaaatgtt gcagaatcag tttattggtg aggacacccg gctgaatatt     2580

aattccagtc ctgatgagca tgagccttta ctgagacgag agcaacaagc tggccatgat     2640

gaaggtgttc tggatcgtct tgtggacagg agggaacggc cactagaagg tggccgaact     2700

aattccaata acaacaacag caatccatgt tcagaacaag atgttcttgc acagggtgtt     2760

ccaagcacag cagcagatcc tgggccatca aagcccagaa gagcacagag gcctaattct     2820

ctggatcttt cagccacaaa tgtcctggat ggcagcagta tacagatagg tgagtcaaca     2880

caagatggca aatcaggatc aggtgaaaag atcaagaaac gtgtgaaaac tccctattct     2940

cttaagcggt ggcgcccctc cacctgggtc atctccactg aatcgctgga ctgtgaagtc     3000

aacaataatg gcagtaacag ggcagttcat tccaaatcca gcactgctgt ttaccttgca     3060

gaaggaggca ctgctacaac catggtgtct aaagatatag gaatgaactg tctgtga        3117


<210>  26
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro 
                565                 570                 575     


Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu 
        595                 600                 605             


Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr 
    610                 615                 620                 


Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu 
625                 630                 635                 640 


His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser 
            820                 825                 830         


Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser 
            980                 985                 990         


Thr Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Thr  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Thr Ala  Thr Thr Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210>  27
<211>  600
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  27
gggcccaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcaagct      600


