                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  EXOSOME GENE THERAPY FOR TREATING INNER EAR DISEASE

<130>  U1197.70191WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/173,662
<151>  2021-04-12

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  7483
<212>  DNA
<213>  Homo sapiens

<400>  1
agtgctggct ggacagctgc tctgggcagg agagagaggg agagacaaga gacacacaca       60

gagagacggc gaggaaggga aagacccaga gggacgccta gaacgagact tggagccaga      120

cagaggaaga ggggacgtgt gtttgcagac tggctgggcc cgtgacccag cttcctgagt      180

cctccgtgca ggtggcagct gtaccaggct ggcaggtcac tgagagtggg cagctgggcc      240

ccagaactgt gcctggccca gtgggcagca ggagctcctg acttgggacc atggtgattc      300

ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc gacgtgccca      360

tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat gatgaagaca      420

atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac cccacgtcgg      480

tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc atcttgcgca      540

acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc atcctggtgg      600

ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc cagtatacca      660

acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac tgctacttca      720

acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct ggggccggga      780

agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg cagcactcgt      840

ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg aatgccaaga      900

ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac ttcaacaagc      960

ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca cgtgtctgtc     1020

gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag ggtatgagtg     1080

aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac ttggccatgg     1140

gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac atccgctccg     1200

ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag ctcctggctg     1260

ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac ctggatgcct     1320

gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag gtgaaccccc     1380

cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag acggtgtcca     1440

ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag gggatctacg     1500

ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag cctccctccc     1560

aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg tttgagaact     1620

ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac ctgcagcagt     1680

tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag agcattgact     1740

ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc aacaagccca     1800

tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca gacaccacca     1860

tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc cccaagaaca     1920

accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat gagacccaag     1980

gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg gtccactcct     2040

ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc gccgagacca     2100

ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg ctgatgcgca     2160

cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag ttcaagaagc     2220

ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga atgatggaga     2280

ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag tttgtggagc     2340

ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac ctccgcggga     2400

cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag ataggcaaaa     2460

ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg gacaaagcca     2520

tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac aggtctaact     2580

ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt cacaactgta     2640

ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg caccgctccc     2700

ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc caggcccgct     2760

gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg ctcaccgtgc     2820

aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg gctgagtatc     2880

tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt cggaaggaga     2940

tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc ctggcccagc     3000

tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg cggaagaagg     3060

agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca gacatggtgg     3120

acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag ggccaggcac     3180

ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag gacctggatg     3240

cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa tttgccaagt     3300

tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg ccactcaaac     3360

agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg gtctggatca     3420

ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc atgagtgatg     3480

gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag aagacgtaca     3540

agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag ggccagaaga     3600

agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc aagctcacag     3660

aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac agcatgctgg     3720

aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat ggcatcctgc     3780

ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc cacaacccct     3840

ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc tgtttcgccc     3900

cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg cccggctacg     3960

ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg acacagccgc     4020

ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg cccgtgacat     4080

tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc aaggagctct     4140

gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc ctctacattg     4200

ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg gacgccatct     4260

cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc ccctggaggc     4320

tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac aacgtggcca     4380

ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac aggtgtgaga     4440

aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat ggctctgaga     4500

tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc gagatcacgc     4560

ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag aaggggattt     4620

atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt tatgcccgct     4680

tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca ggccccagtc     4740

tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt gtggatgagc     4800

aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc agcagcaggg     4860

agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg cctcactcag     4920

gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc aggggagcga     4980

aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac accttcacct     5040

ccagcaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg ctccggaaga     5100

gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag gagtcaggct     5160

tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc gagcaggtca     5220

tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg gacttcccca     5280

ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt gtggccctgg     5340

tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg cgaacggcgg     5400

agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac tacttcaggc     5460

ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc aaggaccggc     5520

tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc ctgggcagtg     5580

aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac atgggcgact     5640

acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt gagggtcccc     5700

tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag ctgaccgaca     5760

accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc acgggccttt     5820

tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc cgaaagcact     5880

gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac gggtcccgga     5940

agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc cagattttcc     6000

acaaagtcta cttccctgat gacactgacg aggccttcga agtggagtcc agcaccaagg     6060

ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca gagggattca     6120

gcctctttgt caaaattgca gacaaggtcc tcagcgttcc tgagaatgac ttcttctttg     6180

actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag gacggaattg     6240

tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc acggtgccag     6300

ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc aagtatctcc     6360

gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg atctacaggg     6420

tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg cgggagctgg     6480

tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc atcgtcgcct     6540

acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc ctgaagctca     6600

tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact acggagccaa     6660

acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc atcgatccca     6720

aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg agcagcggca     6780

acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg ctctgcgaga     6840

cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag atgctcacag     6900

ccatgagcaa acagcggggc tccaggagcg gcaagtgaac agtcacgggg aggtgctggt     6960

tccatgcctg ctctcgaggc agcagtgggt tcaggcccat cagctacccc tgcagctggg     7020

gaagacttat gccatcccgg cagcgaggct gggctggcca gccaccactg actataccaa     7080

ctgggcctct gatgttcttc cagtgaggca tctctctggg atgcagaact tccctccatc     7140

cacccctctg gcacctgggt tggtctaatc ctagtttgct gtggccttcc cggttgtgag     7200

agcctgtgat ccttagatgt gtctcctgtt tcagaccagc cccaccatgc aacttccttt     7260

gactttctgt gtaccactgg gatagaggaa tcaagaggac aatctagctc tccatacttt     7320

gaacaaccaa atgtgcattg aatactctga aaccgaaggg actggatctg caggtgggat     7380

gagggagaca gaccactttt ctatattgca gtgtgaatgc tgggcccctg ctcaagtcta     7440

ccctgatcac ctcagggcat aaagcatgtt tcattctctg gcc                       7483


<210>  2
<211>  2215
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Trp Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Ala  Pro His Ser Gly Trp  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Ala 
    1550                 1555                 1560             


Lys Thr  Thr Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Ser Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Met  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Leu  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Leu Ala 
    1760                 1765                 1770             


Phe Ile  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Thr Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Gly Pro 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Thr Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Leu Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Lys Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Gly  Ser Arg Ser Gly Lys  
    2210                 2215 


<210>  3
<211>  7363
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgctggct ggacagctgc tctgggcagg agagagaggg agagacaaga gacacacaca       60

gagagacggc gaggaaggga aagacccaga gggacgccta gaacgagact tggagccaga      120

cagaggaaga ggggacgtgt gtttgcagac tggctgggcc cgtgacccag cttcctgagt      180

cctccgtgca ggtggcagct gtaccaggct ggcaggtcac tgagagtggg cagctgggcc      240

ccagaactgt gcctggccca gtgggcagca ggagctcctg acttgggacc atggtgattc      300

ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc gacgtgccca      360

tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat gatgaagaca      420

atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac cccacgtcgg      480

tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc atcttgcgca      540

acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc atcctggtgg      600

ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc cagtatacca      660

acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac tgctacttca      720

acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct ggggccggga      780

agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg cagcactcgt      840

ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg aatgccaaga      900

ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac ttcaacaagc      960

ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca cgtgtctgtc     1020

gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag ggtatgagtg     1080

aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac ttggccatgg     1140

gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac atccgctccg     1200

ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag ctcctggctg     1260

ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac ctggatgcct     1320

gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag gtgaaccccc     1380

cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag acggtgtcca     1440

ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag gggatctacg     1500

ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag cctccctccc     1560

aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg tttgagaact     1620

ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac ctgcagcagt     1680

tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag agcattgact     1740

ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc aacaagccca     1800

tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca gacaccacca     1860

tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc cccaagaaca     1920

accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat gagacccaag     1980

gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg gtccactcct     2040

ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc gccgagacca     2100

ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg ctgatgcgca     2160

cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag ttcaagaagc     2220

ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga atgatggaga     2280

ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag tttgtggagc     2340

ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac ctccgcggga     2400

cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag ataggcaaaa     2460

ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg gacaaagcca     2520

tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac aggtctaact     2580

ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt cacaactgta     2640

ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg caccgctccc     2700

ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc caggcccgct     2760

gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg ctcaccgtgc     2820

aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg gctgagtatc     2880

tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt cggaaggaga     2940

tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc ctggcccagc     3000

tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg cggaagaagg     3060

agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca gacatggtgg     3120

acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag ggccaggcac     3180

ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag gacctggatg     3240

cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa tttgccaagt     3300

tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg ccactcaaac     3360

agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg gtctggatca     3420

ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc atgagtgatg     3480

gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag aagacgtaca     3540

agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag ggccagaaga     3600

agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc aagctcacag     3660

aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac agcatgctgg     3720

aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat ggcatcctgc     3780

ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc cacaacccct     3840

ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc tgtttcgccc     3900

cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg cccggctacg     3960

ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg acacagccgc     4020

ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg cccgtgacat     4080

tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc aaggagctct     4140

gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc ctctacattg     4200

ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg gacgccatct     4260

cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc ccctggaggc     4320

tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac aacgtggcca     4380

ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac aggtgtgaga     4440

aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat ggctctgaga     4500

tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc gagatcacgc     4560

ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag aaggggattt     4620

atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt tatgcccgct     4680

tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca ggccccagtc     4740

tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt gtggatgagc     4800

aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc agcagcaggg     4860

gagcgaaaac gacggccccc agcttcacgc tggccaccat caagggggac gaatacacct     4920

tcacctccag caatgctgag gacattcgtg acctggtggt caccttccta gaggggctcc     4980

ggaagagatc taagtatgtt gtggccctgc aggataaccc caaccccgca ggcgaggagt     5040

caggcttcct cagctttgcc aagggagacc tcatcatcct ggaccatgac acgggcgagc     5100

aggtcatgaa ctcgggctgg gccaacggca tcaatgagag gaccaagcag cgtggggact     5160

tccccaccga cagtgtgtac gtcatgccca ctgtcaccat gccaccgcgg gagattgtgg     5220

ccctggtcac catgactccc gatcagaggc aggacgttgt ccggctcttg cagctgcgaa     5280

cggcggagcc cgaggtgcgt gccaagccct acacgctgga ggagttttcc tatgactact     5340

tcaggccccc acccaagcac acgctgagcc gtgtcatggt gtccaaggcc cgaggcaagg     5400

accggctgtg gagccacacg cgggaaccgc tcaagcaggc gctgctcaag aagctcctgg     5460

gcagtgagga gctctcgcag gaggcctgcc tggccttcat tgctgtgctc aagtacatgg     5520

gcgactaccc gtccaagagg acacgctccg tcaacgagct caccgaccag atctttgagg     5580

gtcccctgaa agccgagccc ctgaaggacg aggcatatgt gcagatcctg aagcagctga     5640

ccgacaacca catcaggtac agcgaggagc ggggttggga gctgctctgg ctgtgcacgg     5700

gccttttccc acccagcaac atcctcctgc cccacgtgca gcgcttcctg cagtcccgaa     5760

agcactgccc actcgccatc gactgcctgc aacggctcca gaaagccctg agaaacgggt     5820

cccggaagta ccctccgcac ctggtggagg tggaggccat ccagcacaag accacccaga     5880

ttttccacaa agtctacttc cctgatgaca ctgacgaggc cttcgaagtg gagtccagca     5940

ccaaggccaa ggacttctgc cagaacatcg ccaccaggct gctcctcaag tcctcagagg     6000

gattcagcct ctttgtcaaa attgcagaca aggtcctcag cgttcctgag aatgacttct     6060

tctttgactt tgttcgacac ttgacagact ggataaagaa agctcggccc atcaaggacg     6120

gaattgtgcc ctcactcacc taccaggtgt tcttcatgaa gaagctgtgg accaccacgg     6180

tgccagggaa ggatcccatg gccgattcca tcttccacta ttaccaggag ttgcccaagt     6240

atctccgagg ctaccacaag tgcacgcggg aggaggtgct gcagctgggg gcgctgatct     6300

acagggtcaa gttcgaggag gacaagtcct acttccccag catccccaag ctgctgcggg     6360

agctggtgcc ccaggacctt atccggcagg tctcacctga tgactggaag cggtccatcg     6420

tcgcctactt caacaagcac gcagggaagt ccaaggagga ggccaagctg gccttcctga     6480

agctcatctt caagtggccc acctttggct cagccttctt cgagcaaact acggagccaa     6540

acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc atcgatccca     6600

aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg agcagcggca     6660

acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg ctctgcgaga     6720

cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag atgctcacag     6780

ccatgagcaa acagcggggc tccaggagcg gcaagtgaac agtcacgggg aggtgctggt     6840

tccatgcctg ctctcgaggc agcagtgggt tcaggcccat cagctacccc tgcagctggg     6900

gaagacttat gccatcccgg cagcgaggct gggctggcca gccaccactg actataccaa     6960

ctgggcctct gatgttcttc cagtgaggca tctctctggg atgcagaact tccctccatc     7020

cacccctctg gcacctgggt tggtctaatc ctagtttgct gtggccttcc cggttgtgag     7080

agcctgtgat ccttagatgt gtctcctgtt tcagaccagc cccaccatgc aacttccttt     7140

gactttctgt gtaccactgg gatagaggaa tcaagaggac aatctagctc tccatacttt     7200

gaacaaccaa atgtgcattg aatactctga aaccgaaggg actggatctg caggtgggat     7260

gagggagaca gaccactttt ctatattgca gtgtgaatgc tgggcccctg ctcaagtcta     7320

ccctgatcac ctcagggcat aaagcatgtt tcattctctg gcc                       7363


<210>  4
<211>  2175
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 


Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             


Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 


Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Ala Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Ser  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  His Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Lys Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Ser Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Asn Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Thr Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ala Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Ser  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Ser Leu Pro  Lys Asn Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Gly Ala  Lys Thr Thr Ala Pro  Ser Phe Thr 
    1520                 1525                 1530             


Leu Ala  Thr Ile Lys Gly Asp  Glu Tyr Thr Phe Thr  Ser Ser Asn 
    1535                 1540                 1545             


Ala Glu  Asp Ile Arg Asp Leu  Val Val Thr Phe Leu  Glu Gly Leu 
    1550                 1555                 1560             


Arg Lys  Arg Ser Lys Tyr Val  Val Ala Leu Gln Asp  Asn Pro Asn 
    1565                 1570                 1575             


Pro Ala  Gly Glu Glu Ser Gly  Phe Leu Ser Phe Ala  Lys Gly Asp 
    1580                 1585                 1590             


Leu Ile  Ile Leu Asp His Asp  Thr Gly Glu Gln Val  Met Asn Ser 
    1595                 1600                 1605             


Gly Trp  Ala Asn Gly Ile Asn  Glu Arg Thr Lys Gln  Arg Gly Asp 
    1610                 1615                 1620             


Phe Pro  Thr Asp Ser Val Tyr  Val Met Pro Thr Val  Thr Met Pro 
    1625                 1630                 1635             


Pro Arg  Glu Ile Val Ala Leu  Val Thr Met Thr Pro  Asp Gln Arg 
    1640                 1645                 1650             


Gln Asp  Val Val Arg Leu Leu  Gln Leu Arg Thr Ala  Glu Pro Glu 
    1655                 1660                 1665             


Val Arg  Ala Lys Pro Tyr Thr  Leu Glu Glu Phe Ser  Tyr Asp Tyr 
    1670                 1675                 1680             


Phe Arg  Pro Pro Pro Lys His  Thr Leu Ser Arg Val  Met Val Ser 
    1685                 1690                 1695             


Lys Ala  Arg Gly Lys Asp Arg  Leu Trp Ser His Thr  Arg Glu Pro 
    1700                 1705                 1710             


Leu Lys  Gln Ala Leu Leu Lys  Lys Leu Leu Gly Ser  Glu Glu Leu 
    1715                 1720                 1725             


Ser Gln  Glu Ala Cys Leu Ala  Phe Ile Ala Val Leu  Lys Tyr Met 
    1730                 1735                 1740             


Gly Asp  Tyr Pro Ser Lys Arg  Thr Arg Ser Val Asn  Glu Leu Thr 
    1745                 1750                 1755             


Asp Gln  Ile Phe Glu Gly Pro  Leu Lys Ala Glu Pro  Leu Lys Asp 
    1760                 1765                 1770             


Glu Ala  Tyr Val Gln Ile Leu  Lys Gln Leu Thr Asp  Asn His Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Glu Glu Arg Gly  Trp Glu Leu Leu Trp  Leu Cys Thr 
    1790                 1795                 1800             


Gly Leu  Phe Pro Pro Ser Asn  Ile Leu Leu Pro His  Val Gln Arg 
    1805                 1810                 1815             


Phe Leu  Gln Ser Arg Lys His  Cys Pro Leu Ala Ile  Asp Cys Leu 
    1820                 1825                 1830             


Gln Arg  Leu Gln Lys Ala Leu  Arg Asn Gly Ser Arg  Lys Tyr Pro 
    1835                 1840                 1845             


Pro His  Leu Val Glu Val Glu  Ala Ile Gln His Lys  Thr Thr Gln 
    1850                 1855                 1860             


Ile Phe  His Lys Val Tyr Phe  Pro Asp Asp Thr Asp  Glu Ala Phe 
    1865                 1870                 1875             


Glu Val  Glu Ser Ser Thr Lys  Ala Lys Asp Phe Cys  Gln Asn Ile 
    1880                 1885                 1890             


Ala Thr  Arg Leu Leu Leu Lys  Ser Ser Glu Gly Phe  Ser Leu Phe 
    1895                 1900                 1905             


Val Lys  Ile Ala Asp Lys Val  Leu Ser Val Pro Glu  Asn Asp Phe 
    1910                 1915                 1920             


Phe Phe  Asp Phe Val Arg His  Leu Thr Asp Trp Ile  Lys Lys Ala 
    1925                 1930                 1935             


Arg Pro  Ile Lys Asp Gly Ile  Val Pro Ser Leu Thr  Tyr Gln Val 
    1940                 1945                 1950             


Phe Phe  Met Lys Lys Leu Trp  Thr Thr Thr Val Pro  Gly Lys Asp 
    1955                 1960                 1965             


Pro Met  Ala Asp Ser Ile Phe  His Tyr Tyr Gln Glu  Leu Pro Lys 
    1970                 1975                 1980             


Tyr Leu  Arg Gly Tyr His Lys  Cys Thr Arg Glu Glu  Val Leu Gln 
    1985                 1990                 1995             


Leu Gly  Ala Leu Ile Tyr Arg  Val Lys Phe Glu Glu  Asp Lys Ser 
    2000                 2005                 2010             


Tyr Phe  Pro Ser Ile Pro Lys  Leu Leu Arg Glu Leu  Val Pro Gln 
    2015                 2020                 2025             


Asp Leu  Ile Arg Gln Val Ser  Pro Asp Asp Trp Lys  Arg Ser Ile 
    2030                 2035                 2040             


Val Ala  Tyr Phe Asn Lys His  Ala Gly Lys Ser Lys  Glu Glu Ala 
    2045                 2050                 2055             


Lys Leu  Ala Phe Leu Lys Leu  Ile Phe Lys Trp Pro  Thr Phe Gly 
    2060                 2065                 2070             


Ser Ala  Phe Phe Glu Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile 
    2075                 2080                 2085             


Leu Leu  Ile Ala Ile Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro 
    2090                 2095                 2100             


Lys Thr  Lys Asp Ile Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser 
    2105                 2110                 2115             


Asn Trp  Ser Ser Gly Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn 
    2120                 2125                 2130             


Leu Val  Arg Gly Ser Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr 
    2135                 2140                 2145             


Lys Met  Asp Asp Leu Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr 
    2150                 2155                 2160             


Ala Met  Ser Lys Gln Arg Gly  Ser Arg Ser Gly Lys  
    2165                 2170                 2175 


<210>  5
<211>  7449
<212>  DNA
<213>  Homo sapiens

<400>  5
agtgctggct ggacagctgc tctgggcagg agagagaggg agagacaaga gacacacaca       60

gagagacggc gaggaaggga aagacccaga gggacgccta gaacgagact tggagccaga      120

cagaggaaga ggggacgtgt gtttgcagac tggctgggcc cgtgacccag cttcctgagt      180

cctccgtgca ggtggcagct gtaccaggct ggcaggtcac tgagagtggg cagctgggcc      240

ccagaactgt gcctggccca gtgggcagca ggagctcctg acttgggacc atggtgattc      300

ttcagcagga gaaaagctgg gacttgcccc acgttacaca gccacactga ggcatgtgtc      360

gtgtcacaaa cgagatcttc cattcaaggg ggaccatgtg tggatggacc tgagattggg      420

gcaggagttc gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca      480

ggtggtggat gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa      540

gcctatgcac cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa      600

cgaggcgggc atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta      660

tacgggctcc atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga      720

gcacatccgc cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat      780

tgctgacaac tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag      840

tggggaatct ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc      900

catcagtggg cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga      960

agcatttggg aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat     1020

cgacatccac ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct     1080

ggaaaagtca cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg     1140

catgctggag ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga     1200

ctacaactac ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga     1260

gtacgccaac atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga     1320

gatctcgaag ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac     1380

atttgaaaac ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc     1440

cctgcttgag gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac     1500

ccgcggggag acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc     1560

cttcgtaaag gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc     1620

aatttacaag cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga     1680

catctttggg tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc     1740

caatgagcac ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata     1800

tgacctggag agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga     1860

catgattgcc aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc     1920

caagggcaca gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa     1980

ctacatcccc cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat     2040

cgtctactat gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat     2100

tatccagctg gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt     2160

cgccatgggc gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc     2220

actggagctg ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa     2280

gcccaatgag ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg     2340

gtactcagga atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag     2400

cttcgtagag tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa     2460

gcagggcgac ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga     2520

tgactggcag ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga     2580

agtggagcgg gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg     2640

attcaaagac aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca     2700

ctggcggggt cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct     2760

gcaggccctg caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat     2820

catccagttc caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct     2880

ctgggctgtg ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca     2940

acgcctcagg gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga     3000

agagaagctt cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca     3060

tcaggagcgc ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga     3120

ggccgctcgg cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt     3180

caatcactca gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc     3240

aggccaggag ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat     3300

ggtggaggag gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc     3360

tgagtataaa tttgccaagt tcgcggccac ctacttccag gggacaacca cgcactccta     3420

cacccggcgg ccactcaaac agccactgct ctaccatgac gacgagggtg accagctggc     3480

agccctggcg gtctggatca ccatcctccg cttcatgggg gacctccctg agcccaagta     3540

ccacacagcc atgagtgatg gcagtgagaa gatccctgtg atgaccaaga tttatgagac     3600

cctgggcaag aagacgtaca agagggagct gcaggccctg cagggcgagg gcgaggccca     3660

gctccccgag ggccagaaga agagcagtgt gaggcacaag ctggtgcatt tgactctgaa     3720

aaagaagtcc aagctcacag aggaggtgac caagaggctg catgacgggg agtccacagt     3780

gcagggcaac agcatgctgg aggaccggcc cacctccaac ctggagaagc tgcacttcat     3840

catcggcaat ggcatcctgc ggccagcact ccgggacgag atctactgcc agatcagcaa     3900

gcagctgacc cacaacccct ccaagagcag ctatgcccgg ggctggattc tcgtgtctct     3960

ctgcgtgggc tgtttcgccc cctccgagaa gtttgtcaag tacctgcgga acttcatcca     4020

cgggggcccg cccggctacg ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa     4080

tgggacacgg acacagccgc ccagctggct ggagctgcag gccaccaagt ccaagaagcc     4140

aatcatgttg cccgtgacat tcatggatgg gaccaccaag accctgctga cggactcggc     4200

aaccacggcc aaggagctct gcaacgcgct ggccgacaag atctctctca aggaccggtt     4260

cgggttctcc ctctacattg ccctgtttga caaggtgtcc tccctgggca gcggcagtga     4320

ccacgtcatg gacgccatct cccagtgcga gcagtacgcc aaggagcagg gcgcccagga     4380

gcgcaacgcc ccctggaggc tcttcttccg caaagaggtc ttcacgccct ggcacagccc     4440

ctccgaggac aacgtggcca ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt     4500

tggggagtac aggtgtgaga aggaggacga cctggctgag ctggcctccc agcagtactt     4560

tgtagactat ggctctgaga tgatcctgga gcgcctcctg aacctcgtgc ccacctacat     4620

ccccgaccgc gagatcacgc ccctgaagac gctggagaag tgggcccagc tggccatcgc     4680

cgcccacaag aaggggattt atgcccagag gagaactgat gcccagaagg tcaaagagga     4740

tgtggtcagt tatgcccgct tcaagtggcc cttgctcttc tccaggtttt atgaagccta     4800

caaattctca ggccccagtc tccccaagaa cgacgtcatc gtggccgtca actggacggg     4860

tgtgtacttt gtggatgagc aggagcaggt acttctggag ctgtccttcc cagagatcat     4920

ggccgtgtcc agcagcaggg gagcgaaaac gacggccccc agcttcacgc tggccaccat     4980

caagggggac gaatacacct tcacctccag caatgctgag gacattcgtg acctggtggt     5040

caccttccta gaggggctcc ggaagagatc taagtatgtt gtggccctgc aggataaccc     5100

caaccccgca ggcgaggagt caggcttcct cagctttgcc aagggagacc tcatcatcct     5160

ggaccatgac acgggcgagc aggtcatgaa ctcgggctgg gccaacggca tcaatgagag     5220

gaccaagcag cgtggggact tccccaccga cagtgtgtac gtcatgccca ctgtcaccat     5280

gccaccgcgg gagattgtgg ccctggtcac catgactccc gatcagaggc aggacgttgt     5340

ccggctcttg cagctgcgaa cggcggagcc cgaggtgcgt gccaagccct acacgctgga     5400

ggagttttcc tatgactact tcaggccccc acccaagcac acgctgagcc gtgtcatggt     5460

gtccaaggcc cgaggcaagg accggctgtg gagccacacg cgggaaccgc tcaagcaggc     5520

gctgctcaag aagctcctgg gcagtgagga gctctcgcag gaggcctgcc tggccttcat     5580

tgctgtgctc aagtacatgg gcgactaccc gtccaagagg acacgctccg tcaacgagct     5640

caccgaccag atctttgagg gtcccctgaa agccgagccc ctgaaggacg aggcatatgt     5700

gcagatcctg aagcagctga ccgacaacca catcaggtac agcgaggagc ggggttggga     5760

gctgctctgg ctgtgcacgg gccttttccc acccagcaac atcctcctgc cccacgtgca     5820

gcgcttcctg cagtcccgaa agcactgccc actcgccatc gactgcctgc aacggctcca     5880

gaaagccctg agaaacgggt cccggaagta ccctccgcac ctggtggagg tggaggccat     5940

ccagcacaag accacccaga ttttccacaa agtctacttc cctgatgaca ctgacgaggc     6000

cttcgaagtg gagtccagca ccaaggccaa ggacttctgc cagaacatcg ccaccaggct     6060

gctcctcaag tcctcagagg gattcagcct ctttgtcaaa attgcagaca aggtcctcag     6120

cgttcctgag aatgacttct tctttgactt tgttcgacac ttgacagact ggataaagaa     6180

agctcggccc atcaaggacg gaattgtgcc ctcactcacc taccaggtgt tcttcatgaa     6240

gaagctgtgg accaccacgg tgccagggaa ggatcccatg gccgattcca tcttccacta     6300

ttaccaggag ttgcccaagt atctccgagg ctaccacaag tgcacgcggg aggaggtgct     6360

gcagctgggg gcgctgatct acagggtcaa gttcgaggag gacaagtcct acttccccag     6420

catccccaag ctgctgcggg agctggtgcc ccaggacctt atccggcagg tctcacctga     6480

tgactggaag cggtccatcg tcgcctactt caacaagcac gcagggaagt ccaaggagga     6540

ggccaagctg gccttcctga agctcatctt caagtggccc acctttggct cagccttctt     6600

cgaggtgaag caaactacgg agccaaactt ccctgagatc ctcctaattg ccatcaacaa     6660

gtatggggtc agcctcatcg atcccaaaac gaaggatatc ctcaccactc atcccttcac     6720

caagatctcc aactggagca gcggcaacac ctacttccac atcaccattg ggaacttggt     6780

gcgcgggagc aaactgctct gcgagacgtc actgggctac aagatggatg acctcctgac     6840

ttcctacatt agccagatgc tcacagccat gagcaaacag cggggctcca ggagcggcaa     6900

gtgaacagtc acggggaggt gctggttcca tgcctgctct cgaggcagca gtgggttcag     6960

gcccatcagc tacccctgca gctggggaag acttatgcca tcccggcagc gaggctgggc     7020

tggccagcca ccactgacta taccaactgg gcctctgatg ttcttccagt gaggcatctc     7080

tctgggatgc agaacttccc tccatccacc cctctggcac ctgggttggt ctaatcctag     7140

tttgctgtgg ccttcccggt tgtgagagcc tgtgatcctt agatgtgtct cctgtttcag     7200

accagcccca ccatgcaact tcctttgact ttctgtgtac cactgggata gaggaatcaa     7260

gaggacaatc tagctctcca tactttgaac aaccaaatgt gcattgaata ctctgaaacc     7320

gaagggactg gatctgcagg tgggatgagg gagacagacc acttttctat attgcagtgt     7380

gaatgctggg cccctgctca agtctaccct gatcacctca gggcataaag catgtttcat     7440

tctctggcc                                                             7449


<210>  6
<211>  2166
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Leu Arg Leu Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val 
1               5                   10                  15      


Val Lys Leu Cys Asp Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp 
            20                  25                  30          


Asn Glu His Trp Ile Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met 
        35                  40                  45              


His Pro Thr Ser Val His Gly Val Glu Asp Met Ile Arg Leu Gly Asp 
    50                  55                  60                  


Leu Asn Glu Ala Gly Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp 
65                  70                  75                  80  


His Leu Ile Tyr Thr Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro 
                85                  90                  95      


Tyr Gln Leu Leu Ser Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr 
            100                 105                 110         


Asn Lys Lys Ile Gly Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp 
        115                 120                 125             


Asn Cys Tyr Phe Asn Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile 
    130                 135                 140                 


Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile 
145                 150                 155                 160 


Leu Gln Phe Leu Ala Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln 
                165                 170                 175     


Gln Val Leu Glu Ala Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys 
            180                 185                 190         


Thr Ile Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile 
        195                 200                 205             


His Phe Asn Lys Arg Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr 
    210                 215                 220                 


Leu Leu Glu Lys Ser Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn 
225                 230                 235                 240 


Tyr His Val Phe Tyr Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys 
                245                 250                 255     


Lys Lys Leu Gly Leu Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met 
            260                 265                 270         


Gly Asn Cys Ile Thr Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala 
        275                 280                 285             


Asn Ile Arg Ser Ala Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn 
    290                 295                 300                 


Trp Glu Ile Ser Lys Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu 
305                 310                 315                 320 


Gln Tyr Glu Ala Arg Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu 
                325                 330                 335     


Phe Ser Pro Ser Leu Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro 
            340                 345                 350         


Pro Asp Leu Met Ser Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly 
        355                 360                 365             


Glu Thr Val Ser Thr Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg 
    370                 375                 380                 


Asp Ala Phe Val Lys Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val 
385                 390                 395                 400 


Asp Lys Ile Asn Ala Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys 
                405                 410                 415     


Asn Ser Arg Arg Ser Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn 
            420                 425                 430         


Phe Ala Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu 
        435                 440                 445             


His Leu Gln Gln Phe Phe Val Arg His Val Phe Lys Leu Glu Gln Glu 
    450                 455                 460                 


Glu Tyr Asp Leu Glu Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp 
465                 470                 475                 480 


Asn Gln Asp Ala Leu Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile 
                485                 490                 495     


Ser Leu Ile Asp Glu Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr 
            500                 505                 510         


Met Leu His Lys Leu Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile 
        515                 520                 525             


Pro Pro Lys Asn Asn His Glu Thr Gln Phe Gly Ile Asn His Phe Ala 
    530                 535                 540                 


Gly Ile Val Tyr Tyr Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp 
545                 550                 555                 560 


Thr Leu His Gly Asp Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys 
                565                 570                 575     


Phe Ile Lys Gln Ile Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr 
            580                 585                 590         


Arg Lys Arg Ser Pro Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu 
        595                 600                 605             


Leu Leu Met Arg Thr Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys 
    610                 615                 620                 


Ile Lys Pro Asn Glu Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu 
625                 630                 635                 640 


Cys Val Arg Gln Leu Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile 
                645                 650                 655     


Arg Arg Ala Gly Tyr Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu 
            660                 665                 670         


Arg Tyr Arg Val Leu Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly 
        675                 680                 685             


Asp Leu Arg Gly Thr Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr 
    690                 695                 700                 


His Asp Asp Trp Gln Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His 
705                 710                 715                 720 


His Asp Met Leu Leu Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg 
                725                 730                 735     


Val Ile Leu Leu Gln Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn 
            740                 745                 750         


Phe Leu Lys Leu Lys Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg 
        755                 760                 765             


Gly His Asn Cys Arg Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu 
    770                 775                 780                 


Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg 
785                 790                 795                 800 


Leu Ala Arg Gln Arg Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr 
                805                 810                 815     


Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Leu Thr Val 
            820                 825                 830         


Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu 
        835                 840                 845             


Arg Ala Glu Tyr Leu Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala 
    850                 855                 860                 


Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu 
865                 870                 875                 880 


Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu 
                885                 890                 895     


Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys 
            900                 905                 910         


Glu Leu Leu Glu Gln Met Glu Arg Ala Arg His Glu Pro Val Asn His 
        915                 920                 925             


Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly 
    930                 935                 940                 


Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu 
945                 950                 955                 960 


Arg Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro 
                965                 970                 975     


Leu Pro Asp Glu Asp Glu Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys 
            980                 985                 990         


Phe Ala Ala Thr Tyr Phe Gln Gly  Thr Thr Thr His Ser  Tyr Thr Arg 
        995                 1000                 1005             


Arg Pro  Leu Lys Gln Pro Leu  Leu Tyr His Asp Asp  Glu Gly Asp 
    1010                 1015                 1020             


Gln Leu  Ala Ala Leu Ala Val  Trp Ile Thr Ile Leu  Arg Phe Met 
    1025                 1030                 1035             


Gly Asp  Leu Pro Glu Pro Lys  Tyr His Thr Ala Met  Ser Asp Gly 
    1040                 1045                 1050             


Ser Glu  Lys Ile Pro Val Met  Thr Lys Ile Tyr Glu  Thr Leu Gly 
    1055                 1060                 1065             


Lys Lys  Thr Tyr Lys Arg Glu  Leu Gln Ala Leu Gln  Gly Glu Gly 
    1070                 1075                 1080             


Glu Ala  Gln Leu Pro Glu Gly  Gln Lys Lys Ser Ser  Val Arg His 
    1085                 1090                 1095             


Lys Leu  Val His Leu Thr Leu  Lys Lys Lys Ser Lys  Leu Thr Glu 
    1100                 1105                 1110             


Glu Val  Thr Lys Arg Leu His  Asp Gly Glu Ser Thr  Val Gln Gly 
    1115                 1120                 1125             


Asn Ser  Met Leu Glu Asp Arg  Pro Thr Ser Asn Leu  Glu Lys Leu 
    1130                 1135                 1140             


His Phe  Ile Ile Gly Asn Gly  Ile Leu Arg Pro Ala  Leu Arg Asp 
    1145                 1150                 1155             


Glu Ile  Tyr Cys Gln Ile Ser  Lys Gln Leu Thr His  Asn Pro Ser 
    1160                 1165                 1170             


Lys Ser  Ser Tyr Ala Arg Gly  Trp Ile Leu Val Ser  Leu Cys Val 
    1175                 1180                 1185             


Gly Cys  Phe Ala Pro Ser Glu  Lys Phe Val Lys Tyr  Leu Arg Asn 
    1190                 1195                 1200             


Phe Ile  His Gly Gly Pro Pro  Gly Tyr Ala Pro Tyr  Cys Glu Glu 
    1205                 1210                 1215             


Arg Leu  Arg Arg Thr Phe Val  Asn Gly Thr Arg Thr  Gln Pro Pro 
    1220                 1225                 1230             


Ser Trp  Leu Glu Leu Gln Ala  Thr Lys Ser Lys Lys  Pro Ile Met 
    1235                 1240                 1245             


Leu Pro  Val Thr Phe Met Asp  Gly Thr Thr Lys Thr  Leu Leu Thr 
    1250                 1255                 1260             


Asp Ser  Ala Thr Thr Ala Lys  Glu Leu Cys Asn Ala  Leu Ala Asp 
    1265                 1270                 1275             


Lys Ile  Ser Leu Lys Asp Arg  Phe Gly Phe Ser Leu  Tyr Ile Ala 
    1280                 1285                 1290             


Leu Phe  Asp Lys Val Ser Ser  Leu Gly Ser Gly Ser  Asp His Val 
    1295                 1300                 1305             


Met Asp  Ala Ile Ser Gln Cys  Glu Gln Tyr Ala Lys  Glu Gln Gly 
    1310                 1315                 1320             


Ala Gln  Glu Arg Asn Ala Pro  Trp Arg Leu Phe Phe  Arg Lys Glu 
    1325                 1330                 1335             


Val Phe  Thr Pro Trp His Ser  Pro Ser Glu Asp Asn  Val Ala Thr 
    1340                 1345                 1350             


Asn Leu  Ile Tyr Gln Gln Val  Val Arg Gly Val Lys  Phe Gly Glu 
    1355                 1360                 1365             


Tyr Arg  Cys Glu Lys Glu Asp  Asp Leu Ala Glu Leu  Ala Ser Gln 
    1370                 1375                 1380             


Gln Tyr  Phe Val Asp Tyr Gly  Ser Glu Met Ile Leu  Glu Arg Leu 
    1385                 1390                 1395             


Leu Asn  Leu Val Pro Thr Tyr  Ile Pro Asp Arg Glu  Ile Thr Pro 
    1400                 1405                 1410             


Leu Lys  Thr Leu Glu Lys Trp  Ala Gln Leu Ala Ile  Ala Ala His 
    1415                 1420                 1425             


Lys Lys  Gly Ile Tyr Ala Gln  Arg Arg Thr Asp Ala  Gln Lys Val 
    1430                 1435                 1440             


Lys Glu  Asp Val Val Ser Tyr  Ala Arg Phe Lys Trp  Pro Leu Leu 
    1445                 1450                 1455             


Phe Ser  Arg Phe Tyr Glu Ala  Tyr Lys Phe Ser Gly  Pro Ser Leu 
    1460                 1465                 1470             


Pro Lys  Asn Asp Val Ile Val  Ala Val Asn Trp Thr  Gly Val Tyr 
    1475                 1480                 1485             


Phe Val  Asp Glu Gln Glu Gln  Val Leu Leu Glu Leu  Ser Phe Pro 
    1490                 1495                 1500             


Glu Ile  Met Ala Val Ser Ser  Ser Arg Gly Ala Lys  Thr Thr Ala 
    1505                 1510                 1515             


Pro Ser  Phe Thr Leu Ala Thr  Ile Lys Gly Asp Glu  Tyr Thr Phe 
    1520                 1525                 1530             


Thr Ser  Ser Asn Ala Glu Asp  Ile Arg Asp Leu Val  Val Thr Phe 
    1535                 1540                 1545             


Leu Glu  Gly Leu Arg Lys Arg  Ser Lys Tyr Val Val  Ala Leu Gln 
    1550                 1555                 1560             


Asp Asn  Pro Asn Pro Ala Gly  Glu Glu Ser Gly Phe  Leu Ser Phe 
    1565                 1570                 1575             


Ala Lys  Gly Asp Leu Ile Ile  Leu Asp His Asp Thr  Gly Glu Gln 
    1580                 1585                 1590             


Val Met  Asn Ser Gly Trp Ala  Asn Gly Ile Asn Glu  Arg Thr Lys 
    1595                 1600                 1605             


Gln Arg  Gly Asp Phe Pro Thr  Asp Ser Val Tyr Val  Met Pro Thr 
    1610                 1615                 1620             


Val Thr  Met Pro Pro Arg Glu  Ile Val Ala Leu Val  Thr Met Thr 
    1625                 1630                 1635             


Pro Asp  Gln Arg Gln Asp Val  Val Arg Leu Leu Gln  Leu Arg Thr 
    1640                 1645                 1650             


Ala Glu  Pro Glu Val Arg Ala  Lys Pro Tyr Thr Leu  Glu Glu Phe 
    1655                 1660                 1665             


Ser Tyr  Asp Tyr Phe Arg Pro  Pro Pro Lys His Thr  Leu Ser Arg 
    1670                 1675                 1680             


Val Met  Val Ser Lys Ala Arg  Gly Lys Asp Arg Leu  Trp Ser His 
    1685                 1690                 1695             


Thr Arg  Glu Pro Leu Lys Gln  Ala Leu Leu Lys Lys  Leu Leu Gly 
    1700                 1705                 1710             


Ser Glu  Glu Leu Ser Gln Glu  Ala Cys Leu Ala Phe  Ile Ala Val 
    1715                 1720                 1725             


Leu Lys  Tyr Met Gly Asp Tyr  Pro Ser Lys Arg Thr  Arg Ser Val 
    1730                 1735                 1740             


Asn Glu  Leu Thr Asp Gln Ile  Phe Glu Gly Pro Leu  Lys Ala Glu 
    1745                 1750                 1755             


Pro Leu  Lys Asp Glu Ala Tyr  Val Gln Ile Leu Lys  Gln Leu Thr 
    1760                 1765                 1770             


Asp Asn  His Ile Arg Tyr Ser  Glu Glu Arg Gly Trp  Glu Leu Leu 
    1775                 1780                 1785             


Trp Leu  Cys Thr Gly Leu Phe  Pro Pro Ser Asn Ile  Leu Leu Pro 
    1790                 1795                 1800             


His Val  Gln Arg Phe Leu Gln  Ser Arg Lys His Cys  Pro Leu Ala 
    1805                 1810                 1815             


Ile Asp  Cys Leu Gln Arg Leu  Gln Lys Ala Leu Arg  Asn Gly Ser 
    1820                 1825                 1830             


Arg Lys  Tyr Pro Pro His Leu  Val Glu Val Glu Ala  Ile Gln His 
    1835                 1840                 1845             


Lys Thr  Thr Gln Ile Phe His  Lys Val Tyr Phe Pro  Asp Asp Thr 
    1850                 1855                 1860             


Asp Glu  Ala Phe Glu Val Glu  Ser Ser Thr Lys Ala  Lys Asp Phe 
    1865                 1870                 1875             


Cys Gln  Asn Ile Ala Thr Arg  Leu Leu Leu Lys Ser  Ser Glu Gly 
    1880                 1885                 1890             


Phe Ser  Leu Phe Val Lys Ile  Ala Asp Lys Val Leu  Ser Val Pro 
    1895                 1900                 1905             


Glu Asn  Asp Phe Phe Phe Asp  Phe Val Arg His Leu  Thr Asp Trp 
    1910                 1915                 1920             


Ile Lys  Lys Ala Arg Pro Ile  Lys Asp Gly Ile Val  Pro Ser Leu 
    1925                 1930                 1935             


Thr Tyr  Gln Val Phe Phe Met  Lys Lys Leu Trp Thr  Thr Thr Val 
    1940                 1945                 1950             


Pro Gly  Lys Asp Pro Met Ala  Asp Ser Ile Phe His  Tyr Tyr Gln 
    1955                 1960                 1965             


Glu Leu  Pro Lys Tyr Leu Arg  Gly Tyr His Lys Cys  Thr Arg Glu 
    1970                 1975                 1980             


Glu Val  Leu Gln Leu Gly Ala  Leu Ile Tyr Arg Val  Lys Phe Glu 
    1985                 1990                 1995             


Glu Asp  Lys Ser Tyr Phe Pro  Ser Ile Pro Lys Leu  Leu Arg Glu 
    2000                 2005                 2010             


Leu Val  Pro Gln Asp Leu Ile  Arg Gln Val Ser Pro  Asp Asp Trp 
    2015                 2020                 2025             


Lys Arg  Ser Ile Val Ala Tyr  Phe Asn Lys His Ala  Gly Lys Ser 
    2030                 2035                 2040             


Lys Glu  Glu Ala Lys Leu Ala  Phe Leu Lys Leu Ile  Phe Lys Trp 
    2045                 2050                 2055             


Pro Thr  Phe Gly Ser Ala Phe  Phe Glu Val Lys Gln  Thr Thr Glu 
    2060                 2065                 2070             


Pro Asn  Phe Pro Glu Ile Leu  Leu Ile Ala Ile Asn  Lys Tyr Gly 
    2075                 2080                 2085             


Val Ser  Leu Ile Asp Pro Lys  Thr Lys Asp Ile Leu  Thr Thr His 
    2090                 2095                 2100             


Pro Phe  Thr Lys Ile Ser Asn  Trp Ser Ser Gly Asn  Thr Tyr Phe 
    2105                 2110                 2115             


His Ile  Thr Ile Gly Asn Leu  Val Arg Gly Ser Lys  Leu Leu Cys 
    2120                 2125                 2130             


Glu Thr  Ser Leu Gly Tyr Lys  Met Asp Asp Leu Leu  Thr Ser Tyr 
    2135                 2140                 2145             


Ile Ser  Gln Met Leu Thr Ala  Met Ser Lys Gln Arg  Gly Ser Arg 
    2150                 2155                 2160             


Ser Gly  Lys 
    2165     


<210>  7
<211>  7481
<212>  DNA
<213>  Mus musculus

<400>  7
agtgcaggct ggacagctgc cctgaacaga aagaaagagt gacccaggga gacaagaaac       60

agagtagccc aagggaagcc cacagcagca gcagatcaag gctcaagctg gagctgaaaa      120

tttgcaggct ccagcctcag cttccagagt cctcctgacc tgtgacccct ggctcctggc      180

tgggaggtgg tgactcggag ggtgtggata aaacccagag ctgtgtctgg tcactccggc      240

aggtgtgctg acgtagaagc atggttattc tgcagaaggg ggactatgta tggatggacc      300

tgaagtcagg ccaggagttt gatgtgccca tcggggccgt ggtgaagctc tgcgactcgg      360

gccagatcca ggtggtggat gatgaagaca atgaacactg gatatcccct cagaatgcca      420

cgcacatcaa gccaatgcac cccacatcgg tgcacggcgt ggaggacatg atccgcctgg      480

gggatctcaa cgaggcaggc atccttcgaa accttctcat tcgctaccgg gaccacctca      540

tctatacgta cacaggttcc atcctggtgg ccgtgaaccc ctaccagctg ctctccatct      600

actcgccaga gcacatccgc cagtacacca acaagaagat aggggagatg cccccccaca      660

tcttcgccat tgctgacaac tgctacttca acatgaaacg caacaaccgg gaccagtgct      720

gtattatcag cggggagtcg ggagctggca agacagagag cacaaagttg atcctgcagt      780

tcctggcagc catcagtgga cagcactcat ggatcgagca gcaggtgctg gaggccaccc      840

cgatcctgga agcatttggg aacgccaaga ccatccgcaa cgacaactct agccgctttg      900

gcaagtacat tgacatccac tttaacaagc gtggtgccat cgagggcgcc aaaatagagc      960

aatacctgct ggagaagtca cgtgtctgcc gccaggcccc tgacgagagg aactatcacg     1020

tgttctactg tatgctggag ggcatgaatg aggaggagaa gaagaaactg ggcctaggcc     1080

aggccgctga ctacaactac ttggccatgg gtaactgcat cacctgtgag ggccgcgtgg     1140

acagtcagga gtatgccaac atccgctctg ccatgaaggt tctcatgttc acagacacgg     1200

agaactggga gatctcgaag cttctggctg ccatcctaca catgggcaat ctgcagtatg     1260

aggcccggac atttgagaac ttggatgcgt gtgaagtcct cttctcccca tcgctggcca     1320

cggcagcttc tctgctcgag gtgaaccccc cagacctgat gagctgcctc accagccgca     1380

ccctcatcac ccgtggggag acggtgtcca cccctctcag cagggaacag gcgctggatg     1440

tgcgagatgc ctttgtcaag ggcatctatg ggcggctctt tgtgtggatt gtggagaaga     1500

tcaacgcagc aatctacaag ccaccccccc tggaagtgaa gaactctcgc cggtccatcg     1560

gtctcctgga catctttgga tttgagaact tcactgtgaa cagcttcgag cagctctgca     1620

ttaactttgc caatgagcac ctgcagcaat tcttcgtgcg gcacgtgttc aagctggagc     1680

aggaggagta cgacctggag agcatcgact ggttgcacat tgagttcact gacaaccagg     1740

aagcactgga catgattgcc aaccggccta tgaacgtcat ctccctcatc gatgaggaga     1800

gcaagttccc caagggcacg gatgccacca tgctgcataa gctgaactca cagcacaagc     1860

tcaatgccaa ctacgtgcca cccaagaaca gccacgagac ccagtttgga atcaaccact     1920

ttgcgggtgt tgtctattat gagagtcaag gcttcctgga gaagaaccga gacaccctgc     1980

atggggacat catccagctg gtccactctt cccggaacaa gttcataaag cagattttcc     2040

aagctgacgt tgccatgggt gccgagacca ggaagcgctc gcctacactc agcagccagt     2100

tcaagcggtc tctggagctg ctgatgcgca cactgggcgc ctgccagccc ttctttgtgc     2160

gttgtatcaa acccaatgag ttcaagaagc ccatgctctt cgaccggcac ttgtgtgtac     2220

gccagctgcg atattcgggc atgatggaga caatccgcat ccgccacgca ggctacccca     2280

ttcgctacag ctttgtggag tttgtggagc gctaccgggt actgctgcct ggtgtgaagc     2340

cagcatacaa gcagggtgac ctccgaggga catgccagcg catggctgag gctgtgctgg     2400

gcacgcacga tgactggcag attggcaaaa ccaagatctt tctgaaggac caccatgaca     2460

tgttgctgga ggtggagcgg gacaaggcca tcacagacag agtcattctc ctccagaagg     2520

ttatccgggg cttcaaagac aggtccaact tcctgagact gaagagtgct gccacactga     2580

tccagaggca ctggcggggc caccactgta ggaaaaacta tgagctgatt cgtcttggct     2640

tcctgcggct gcaggccctg caccgctccc ggaagctgca caagcagtac cgcctggcca     2700

gacagcgcat aatagagttc caggcccgct gccgggccta tctggtgcgc aaggccttcc     2760

gccaccgcct ctgggccgtg atcaccgtgc aggcctatgc ccgaggcatg attgcccgcc     2820

ggctacaccg ccgcctccgg gttgagtacc agcggcgcct cgaggcagag aggatgcgtc     2880

tggcagagga ggagaaactc cgaaaggaga tgagtgccaa gaaggccaaa gaggaggctg     2940

agcgcaagca tcaggagcgc ctggctcagc tagcccgcga ggatgcggag cgggaactga     3000

aggagaagga ggaggctcgg aggaagaagg aactgctgga gcagatggag aaggcccgcc     3060

acgaacccat caaccactca gatatggtgg acaagatgtt tggcttcctg gggacttcag     3120

gcagcctgcc aggccaggaa ggccaggcgc ctagtggctt tgaggaccta gagcgcggac     3180

ggagggagat ggtggaagag gatgttgacg ctgccctgcc cctgcctgat gaagacgagg     3240

aggacctttc tgagtacaaa ttcgccaagt ttgctgccac ctacttccag ggcacaacca     3300

cacactccta cacccggagg cctctcaagc agccgctgct ctaccacgac gatgagggtg     3360

accagctggc ggcgctggct gtctggatca ccatcctccg gttcatgggg gacctcccag     3420

agcccaagta ccacacagcc atgagcgacg gcagtgagaa gatcccagtg atgactaaga     3480

tctacgagac cctaggcaag aagacatata agagggagct gcaggccttg cagggcgagg     3540

gcgagaccca gctccctgag gggcagaaga agaccagtgt gagacacaag ttggtacact     3600

tgacactgaa gaaaaagtcc aaactcacag aagaggtgac caagaggctg aacgatgggg     3660

aatccacggt acagggcaac agcatgctgg aggatcggcc cacctcaaat ctagagaagc     3720

tgcacttcat catcggcaac ggcatcctgc ggcctgcgct gcgggacgag atttactgcc     3780

agatcagtaa gcagctcaca cacaacccat ccaagagcag ctatgccagg ggctggatcc     3840

tcgtgtcgct ctgtgtgggc tgcttcgccc cctctgagaa gttcgttaag tacctgcgga     3900

acttcatcca cggaggccca cctggctatg ctccttactg tgaggagcgc ctgaggagga     3960

cctttgtcaa cggaactcgg acacagccac ccagctggct ggagctgcag gccaccaagt     4020

ccaagaagcc catcatgttg cccgtgacct tcatggatgg gaccaccaag accctgctaa     4080

cagattcagc aactacagcc agggagctgt gcaatgctct ggctgacaag atctcactca     4140

aggaccgctt tggcttctcc ctctacatcg ctctgttcga taaggtgtcc tccctgggca     4200

gcggcagtga ccatgtcatg gatgccatct ctcagtgtga gcagtacgcc aaggagcagg     4260

gtgctcagga gcgcaacgcc ccatggaggc tcttctttag aaaggaggtc ttcacaccct     4320

ggcacaaccc ctcggaggac aacgtggcca cgaacctcat ctaccagcag gtggtgcgag     4380

gagtcaagtt tggggagtac aggtgtgaga aggaggacga cctggctgag ctggcttctc     4440

agcagtactt tgtggactat ggttctgaga tgattctgga gcgcctgctg agcctcgtgc     4500

ccacttacat ccctgaccgt gagatcacac cgctgaagaa tcttgagaag tgggcacagc     4560

tggccattgc tgcccacaag aagggaattt atgcccagag gagaactgac tcccagaagg     4620

tcaaagagga tgtggtcaat tatgcccgtt tcaagtggcc cttgctcttc tccaggtttt     4680

acgaagctta caaattctca ggccctcccc tccccaagag cgacgtcatc gtggctgtca     4740

actggacggg tgtgtacttc gtggacgagc aggagcaggt gcttctggag ctgtccttcc     4800

cggagatcat ggctgtgtcc agcagtaggg agtgccgcgt cttgctctca ctgggctgct     4860

ctgacttggg ctgtgctact tgtcaatcgg gccgggcagg gctgaccccg gctggaccct     4920

gttctccgtg ttggtcctgt aggggaacaa agatgatggc ccccagcttt accctggcca     4980

ccatcaaagg agatgagtac accttcacat ccagcaatgc tgaggacatc cgtgacctgg     5040

tggtcacctt tctggagggg ctacggaaga ggtctaagta tgtggtggca ctgcaggaca     5100

atcctaaccc tgctggtgag gagtcaggct tcctcagctt cgccaaggga gacctcatca     5160

tccttgacca tgatactggt gagcaggtca tgaactcagg ctgggccaac ggcatcaacg     5220

agaggaccaa gcagcgcggc gacttcccca ctgactgtgt atacgtcatg cccactgtca     5280

ccttgccacc aagggagatt gtggccctgg tcactatgac cccagaccag aggcaggatg     5340

tcgtccggct cctgcagctt cgcacagcag agccagaggt gcgcgccaag ccctacacgc     5400

tagaggagtt ctcctacgac tacttcaggc ccccacccaa gcacacgctg agccgtgtca     5460

tggtgtccaa ggcccgcggt aaggacaggc tgtggagcca cacacgagag cccctcaagc     5520

aggccctgct caagaagatc ctgggcagtg aagaactctc ccaggaagcc tgcatggcct     5580

ttgtagctgt gctcaagtac atgggcgact acccatccaa gaggatgcga tccgtcaatg     5640

agctcactga ccagatcttt gagtgggcac tcaaggctga gcccctcaag gatgaggcct     5700

acgtgcagat cctgaagcag ctgactgaca atcacatcag gtacagcgaa gagaggggct     5760

gggaactgct gtggctgtgc acgggcctct tcccgcccag caacatcctc ctgcctcatg     5820

ttcagcggtt tctgcagtcc cgcaagcact gtcctcttgc cattgactgc ctgcagaggc     5880

tccagaaagc cctgagaaat ggctcccgga agtaccctcc gcacctggtg gaggtggagg     5940

ccatccaaca taagactacc cagatcttcc acaaggtcta cttccccgat gacacggacg     6000

aggcttttga ggtggagtcc agcaccaagg ccaaggactt ctgccagaac atcgccagcc     6060

ggctgctgct caagtcttcc gagggattca gcctttttgt caaaatcgca gataaggtca     6120

tcagcgtccc agagaatgat ttcttctttg actttgtccg acacctgaca gactggataa     6180

agaaagcacg gcccatcaag gacggaatcg tgccctcact aacctaccag gtgttcttca     6240

tgaagaagct gtggaccacc acagtgccgg gcaaggaccc catggctgac tccatcttcc     6300

actattacca ggaactgccc aaatatctcc gaggctacca caagtgcacc cgggaggagg     6360

tgctgcagct gggcgcactc atctacaggg tcaagtttga ggaggacaaa tcctacttcc     6420

ctagcatccc caagttgctg agggagctgg taccccagga cctaatccgg caggtctcac     6480

ctgatgactg gaaacggtct attgtcgcct acttcaacaa acatgcgggg aagtccaagg     6540

aggaagccaa gctggccttc ctcaaactca tcttcaagtg gcccaccttt ggctcagcct     6600

tctttgaggt gaagcaaact acagaaccaa acttcccaga gattctctta attgccatca     6660

acaagtacgg ggtcagcctc atcgatccca gaaccaagga catcctgact actcacccct     6720

tcaccaagat ctccaactgg agtagtggca acacctactt ccacatcacc attgggaact     6780

tggtccgtgg gagcaaactg ctctgtgaga catcgctggg atacaaaatg gatgatcttc     6840

tgacttccta catcagccag atgctcacag ccatgagcaa gcagaggaac tccaggagtg     6900

gaaggtgaac ctcagaggag acgctggctc aggccttggc cctctaggca gggaagctgg     6960

actgaccata tctgctgggc atctgatctg cctgccacga ggtccagact cttctgcatc     7020

cacctatggc atctgggttt gctgtcaccc tactttgttg tggccttcct ggtgtaagag     7080

tctgtgttcc ttggtcacct ctcctgattc agaccagctc catcaagcaa cctcttttga     7140

ctttctgtat atggatggca cagaggaatc aaggacaact tagctctctg catacttgga     7200

acaaccaaac tatttgtaca ttgaacggat gctctgaaac ccaagggact gggctcaggg     7260

tcctcagcac tggcccctgt cataagcact accactaagg actctctgga ggactcctca     7320

gtatcatctg ctccaggaag ccccctagac tacctcctga gtctggacaa agcctcctga     7380

ttctacctgg atcactcctg ttatgtgaca gttatgtggt gggtccctgc taaaatctcc     7440

ctgaccacct gagggcataa agcatgtgtc ttattctctg g                         7481


<210>  8
<211>  2215
<212>  PRT
<213>  Mus musculus

<400>  8

Met Val Ile Leu Gln Lys Gly Asp Tyr Val Trp Met Asp Leu Lys Ser 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Ile Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Asn Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Pro Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Asn Glu Glu Glu Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ala Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Met Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Glu Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Pro Leu Glu Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Thr Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Glu Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Arg Pro Met Asn Val Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Ala Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Val Pro Pro Lys Asn Ser 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Val Val Tyr Tyr 
545                 550                 555                 560 


Glu Ser Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg His Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Arg Leu Lys 
        755                 760                 765             


Ser Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His His Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Glu Leu Ile Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Lys Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Glu Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Ile Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Arg Arg Leu Arg Val Glu Tyr Gln 
    850                 855                 860                 


Arg Arg Leu Glu Ala Glu Arg Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Glu Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Lys Ala Arg His Glu Pro Ile Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Ser Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Val Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Thr Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Thr  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  Asn Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Arg Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Asn Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Ser Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Asn Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ser Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Asn  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Pro Leu Pro  Lys Ser Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Glu Cys  Arg Val Leu Leu Ser  Leu Gly Cys 
    1520                 1525                 1530             


Ser Asp  Leu Gly Cys Ala Thr  Cys Gln Ser Gly Arg  Ala Gly Leu 
    1535                 1540                 1545             


Thr Pro  Ala Gly Pro Cys Ser  Pro Cys Trp Ser Cys  Arg Gly Thr 
    1550                 1555                 1560             


Lys Met  Met Ala Pro Ser Phe  Thr Leu Ala Thr Ile  Lys Gly Asp 
    1565                 1570                 1575             


Glu Tyr  Thr Phe Thr Ser Ser  Asn Ala Glu Asp Ile  Arg Asp Leu 
    1580                 1585                 1590             


Val Val  Thr Phe Leu Glu Gly  Leu Arg Lys Arg Ser  Lys Tyr Val 
    1595                 1600                 1605             


Val Ala  Leu Gln Asp Asn Pro  Asn Pro Ala Gly Glu  Glu Ser Gly 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ala Lys Gly  Asp Leu Ile Ile Leu  Asp His Asp 
    1625                 1630                 1635             


Thr Gly  Glu Gln Val Met Asn  Ser Gly Trp Ala Asn  Gly Ile Asn 
    1640                 1645                 1650             


Glu Arg  Thr Lys Gln Arg Gly  Asp Phe Pro Thr Asp  Cys Val Tyr 
    1655                 1660                 1665             


Val Met  Pro Thr Val Thr Leu  Pro Pro Arg Glu Ile  Val Ala Leu 
    1670                 1675                 1680             


Val Thr  Met Thr Pro Asp Gln  Arg Gln Asp Val Val  Arg Leu Leu 
    1685                 1690                 1695             


Gln Leu  Arg Thr Ala Glu Pro  Glu Val Arg Ala Lys  Pro Tyr Thr 
    1700                 1705                 1710             


Leu Glu  Glu Phe Ser Tyr Asp  Tyr Phe Arg Pro Pro  Pro Lys His 
    1715                 1720                 1725             


Thr Leu  Ser Arg Val Met Val  Ser Lys Ala Arg Gly  Lys Asp Arg 
    1730                 1735                 1740             


Leu Trp  Ser His Thr Arg Glu  Pro Leu Lys Gln Ala  Leu Leu Lys 
    1745                 1750                 1755             


Lys Ile  Leu Gly Ser Glu Glu  Leu Ser Gln Glu Ala  Cys Met Ala 
    1760                 1765                 1770             


Phe Val  Ala Val Leu Lys Tyr  Met Gly Asp Tyr Pro  Ser Lys Arg 
    1775                 1780                 1785             


Met Arg  Ser Val Asn Glu Leu  Thr Asp Gln Ile Phe  Glu Trp Ala 
    1790                 1795                 1800             


Leu Lys  Ala Glu Pro Leu Lys  Asp Glu Ala Tyr Val  Gln Ile Leu 
    1805                 1810                 1815             


Lys Gln  Leu Thr Asp Asn His  Ile Arg Tyr Ser Glu  Glu Arg Gly 
    1820                 1825                 1830             


Trp Glu  Leu Leu Trp Leu Cys  Thr Gly Leu Phe Pro  Pro Ser Asn 
    1835                 1840                 1845             


Ile Leu  Leu Pro His Val Gln  Arg Phe Leu Gln Ser  Arg Lys His 
    1850                 1855                 1860             


Cys Pro  Leu Ala Ile Asp Cys  Leu Gln Arg Leu Gln  Lys Ala Leu 
    1865                 1870                 1875             


Arg Asn  Gly Ser Arg Lys Tyr  Pro Pro His Leu Val  Glu Val Glu 
    1880                 1885                 1890             


Ala Ile  Gln His Lys Thr Thr  Gln Ile Phe His Lys  Val Tyr Phe 
    1895                 1900                 1905             


Pro Asp  Asp Thr Asp Glu Ala  Phe Glu Val Glu Ser  Ser Thr Lys 
    1910                 1915                 1920             


Ala Lys  Asp Phe Cys Gln Asn  Ile Ala Ser Arg Leu  Leu Leu Lys 
    1925                 1930                 1935             


Ser Ser  Glu Gly Phe Ser Leu  Phe Val Lys Ile Ala  Asp Lys Val 
    1940                 1945                 1950             


Ile Ser  Val Pro Glu Asn Asp  Phe Phe Phe Asp Phe  Val Arg His 
    1955                 1960                 1965             


Leu Thr  Asp Trp Ile Lys Lys  Ala Arg Pro Ile Lys  Asp Gly Ile 
    1970                 1975                 1980             


Val Pro  Ser Leu Thr Tyr Gln  Val Phe Phe Met Lys  Lys Leu Trp 
    1985                 1990                 1995             


Thr Thr  Thr Val Pro Gly Lys  Asp Pro Met Ala Asp  Ser Ile Phe 
    2000                 2005                 2010             


His Tyr  Tyr Gln Glu Leu Pro  Lys Tyr Leu Arg Gly  Tyr His Lys 
    2015                 2020                 2025             


Cys Thr  Arg Glu Glu Val Leu  Gln Leu Gly Ala Leu  Ile Tyr Arg 
    2030                 2035                 2040             


Val Lys  Phe Glu Glu Asp Lys  Ser Tyr Phe Pro Ser  Ile Pro Lys 
    2045                 2050                 2055             


Leu Leu  Arg Glu Leu Val Pro  Gln Asp Leu Ile Arg  Gln Val Ser 
    2060                 2065                 2070             


Pro Asp  Asp Trp Lys Arg Ser  Ile Val Ala Tyr Phe  Asn Lys His 
    2075                 2080                 2085             


Ala Gly  Lys Ser Lys Glu Glu  Ala Lys Leu Ala Phe  Leu Lys Leu 
    2090                 2095                 2100             


Ile Phe  Lys Trp Pro Thr Phe  Gly Ser Ala Phe Phe  Glu Val Lys 
    2105                 2110                 2115             


Gln Thr  Thr Glu Pro Asn Phe  Pro Glu Ile Leu Leu  Ile Ala Ile 
    2120                 2125                 2130             


Asn Lys  Tyr Gly Val Ser Leu  Ile Asp Pro Arg Thr  Lys Asp Ile 
    2135                 2140                 2145             


Leu Thr  Thr His Pro Phe Thr  Lys Ile Ser Asn Trp  Ser Ser Gly 
    2150                 2155                 2160             


Asn Thr  Tyr Phe His Ile Thr  Ile Gly Asn Leu Val  Arg Gly Ser 
    2165                 2170                 2175             


Lys Leu  Leu Cys Glu Thr Ser  Leu Gly Tyr Lys Met  Asp Asp Leu 
    2180                 2185                 2190             


Leu Thr  Ser Tyr Ile Ser Gln  Met Leu Thr Ala Met  Ser Lys Gln 
    2195                 2200                 2205             


Arg Asn  Ser Arg Ser Gly Arg  
    2210                 2215 


<210>  9
<211>  7214
<212>  DNA
<213>  Mus musculus

<400>  9
ggcgctaggc tgtgagatca tcagaggact ccgttaccca cacagctgcc agaggggagt       60

tgtcaaagtg aaaccccagg gactgggggt gtagtttgtg gggtcagggg gactatgtat      120

ggatggacct gaagtcaggc caggagtttg atgtgcccat cggggccgtg gtgaagctct      180

gcgactcggg ccagatccag gtggtggatg atgaagacaa tgaacactgg atatcccctc      240

agaatgccac gcacatcaag ccaatgcacc ccacatcggt gcacggcgtg gaggacatga      300

tccgcctggg ggatctcaac gaggcaggca tccttcgaaa ccttctcatt cgctaccggg      360

accacctcat ctataccagc tgtggaggac ggacgtacac aggttccatc ctggtggccg      420

tgaaccccta ccagctgctc tccatctact cgccagagca catccgccag tacaccaaca      480

agaagatagg ggagatgccc ccccacatct tcgccattgc tgacaactgc tacttcaaca      540

tgaaacgcaa caaccgggac cagtgctgta ttatcagcgg ggagtcggga gctggcaaga      600

cagagagcac aaagttgatc ctgcagttcc tggcagccat cagtggacag cactcatgga      660

tcgagcagca ggtgctggag gccaccccga tcctggaagc atttgggaac gccaagacca      720

tccgcaacga caactctagc cgctttggca agtacattga catccacttt aacaagcgtg      780

gtgccatcga gggcgccaaa atagagcaat acctgctgga gaagtcacgt gtctgccgcc      840

aggcccctga cgagaggaac tatcacgtgt tctactgtat gctggagggc atgaatgagg      900

aggagaagaa gaaactgggc ctaggccagg ccgctgacta caactacttg gccatgggta      960

actgcatcac ctgtgagggc cgcgtggaca gtcaggagta tgccaacatc cgctctgcca     1020

tgaaggttct catgttcaca gacacggaga actgggagat ctcgaagctt ctggctgcca     1080

tcctacacat gggcaatctg cagtatgagg cccggacatt tgagaacttg gatgcgtgtg     1140

aagtcctctt ctccccatcg ctggccacgg cagcttctct gctcgaggtg aaccccccag     1200

acctgatgag ctgcctcacc agccgcaccc tcatcacccg tggggagacg gtgtccaccc     1260

ctctcagcag ggaacaggcg ctggatgtgc gagatgcctt tgtcaagggc atctatgggc     1320

ggctctttgt gtggattgtg gagaagatca acgcagcaat ctacaagcca ccccccctgg     1380

aagtgaagaa ctctcgccgg tccatcggtc tcctggacat ctttggattt gagaacttca     1440

ctgtgaacag cttcgagcag ctctgcatta actttgccaa tgagcacctg cagcaattct     1500

tcgtgcggca cgtgttcaag ctggagcagg aggagtacga cctggagagc atcgactggt     1560

tgcacattga gttcactgac aaccaggaag cactggacat gattgccaac cggcctatga     1620

acgtcatctc cctcatcgat gaggagagca agttccccaa gggcacggat gccaccatgc     1680

tgcataagct gaactcacag cacaagctca atgccaacta cgtgccaccc aagaacagcc     1740

acgagaccca gtttggaatc aaccactttg cgggtgttgt ctattatgag agtcaaggct     1800

tcctggagaa gaaccgagac accctgcatg gggacatcat ccagctggtc cactcttccc     1860

ggaacaagtt cataaagcag attttccaag ctgacgttgc catgggtgcc gagaccagga     1920

agcgctcgcc tacactcagc agccagttca agcggtctct ggagctgctg atgcgcacac     1980

tgggcgcctg ccagcccttc tttgtgcgtt gtatcaaacc caatgagttc aagaagccca     2040

tgctcttcga ccggcacttg tgtgtacgcc agctgcgata ttcgggcatg atggagacaa     2100

tccgcatccg ccacgcaggc taccccattc gctacagctt tgtggagttt gtggagcgct     2160

accgggtact gctgcctggt gtgaagccag catacaagca gggtgacctc cgagggacat     2220

gccagcgcat ggctgaggct gtgctgggca cgcacgatga ctggcagatt ggcaaaacca     2280

agatctttct gaaggaccac catgacatgt tgctggaggt ggagcgggac aaggccatca     2340

cagacagagt cattctcctc cagaaggtta tccggggctt caaagacagg tccaacttcc     2400

tgagactgaa gagtgctgcc acactgatcc agaggcactg gcggggccac cactgtagga     2460

aaaactatga gctgattcgt cttggcttcc tgcggctgca ggccctgcac cgctcccgga     2520

agctgcacaa gcagtaccgc ctggccagac agcgcataat agagttccag gcccgctgcc     2580

gggcctatct ggtgcgcaag gccttccgcc accgcctctg ggccgtgatc accgtgcagg     2640

cctatgcccg aggcatgatt gcccgccggc tacaccgccg cctccgggtt gagtaccagc     2700

ggcgcctcga ggcagagagg atgcgtctgg cagaggagga gaaactccga aaggagatga     2760

gtgccaagaa ggccaaagag gaggctgagc gcaagcatca ggagcgcctg gctcagctag     2820

cccgcgagga tgcggagcgg gaactgaagg agaaggagga ggctcggagg aagaaggaac     2880

tgctggagca gatggagaag gcccgccacg aacccatcaa ccactcagat atggtggaca     2940

agatgtttgg cttcctgggg acttcaggca gcctgccagg ccaggaaggc caggcgccta     3000

gtggctttga ggacctagag cgcggacgga gggagatggt ggaagaggat gttgacgctg     3060

ccctgcccct gcctgatgaa gacgaggagg acctttctga gtacaaattc gccaagtttg     3120

ctgccaccta cttccagggc acaaccacac actcctacac ccggaggcct ctcaagcagc     3180

cgctgctcta ccacgacgat gagggtgacc agctggcggc gctggctgtc tggatcacca     3240

tcctccggtt catgggggac ctcccagagc ccaagtacca cacagccatg agcgacggca     3300

gtgagaagat cccagtgatg actaagatct acgagaccct aggcaagaag acatataaga     3360

gggagctgca ggccttgcag ggcgagggcg agacccagct ccctgagggg cagaagaaga     3420

ccagtgtgag acacaagttg gtacacttga cactgaagaa aaagtccaaa ctcacagaag     3480

aggtgaccaa gaggctgaac gatggggaat ccacggtaca gggcaacagc atgctggagg     3540

atcggcccac ctcaaatcta gagaagctgc acttcatcat cggcaacggc atcctgcggc     3600

ctgcgctgcg ggacgagatt tactgccaga tcagtaagca gctcacacac aacccatcca     3660

agagcagcta tgccaggggc tggatcctcg tgtcgctctg tgtgggctgc ttcgccccct     3720

ctgagaagtt cgttaagtac ctgcggaact tcatccacgg aggcccacct ggctatgctc     3780

cttactgtga ggagcgcctg aggaggacct ttgtcaacgg aactcggaca cagccaccca     3840

gctggctgga gctgcaggcc accaagtcca agaagcccat catgttgccc gtgaccttca     3900

tggatgggac caccaagacc ctgctaacag attcagcaac tacagccagg gagctgtgca     3960

atgctctggc tgacaagatc tcactcaagg accgctttgg cttctccctc tacatcgctc     4020

tgttcgataa ggtgtcctcc ctgggcagcg gcagtgacca tgtcatggat gccatctctc     4080

agtgtgagca gtacgccaag gagcagggtg ctcaggagcg caacgcccca tggaggctct     4140

tctttagaaa ggaggtcttc acaccctggc acaacccctc ggaggacaac gtggccacga     4200

acctcatcta ccagcaggtg gtgcgaggag tcaagtttgg ggagtacagg tgtgagaagg     4260

aggacgacct ggctgagctg gcttctcagc agtactttgt ggactatggt tctgagatga     4320

ttctggagcg cctgctgagc ctcgtgccca cttacatccc tgaccgtgag atcacaccgc     4380

tgaagaatct tgagaagtgg gcacagctgg ccattgctgc ccacaagaag ggaatttatg     4440

cccagaggag aactgactcc cagaaggtca aagaggatgt ggtcaattat gcccgtttca     4500

agtggccctt gctcttctcc aggttttacg aagcttacaa attctcaggc cctcccctcc     4560

ccaagagcga cgtcatcgtg gctgtcaact ggacgggtgt gtacttcgtg gacgagcagg     4620

agcaggtgct tctggagctg tccttcccgg agatcatggc tgtgtccagc agtaggggaa     4680

caaagatgat ggcccccagc tttaccctgg ccaccatcaa aggagatgag tacaccttca     4740

catccagcaa tgctgaggac atccgtgacc tggtggtcac ctttctggag gggctacgga     4800

agaggtctaa gtatgtggtg gcactgcagg acaatcctaa ccctgctggt gaggagtcag     4860

gcttcctcag cttcgccaag ggagacctca tcatccttga ccatgatact ggtgagcagg     4920

tcatgaactc aggctgggcc aacggcatca acgagaggac caagcagcgc ggcgacttcc     4980

ccactgactg tgtatacgtc atgcccactg tcaccttgcc accaagggag attgtggccc     5040

tggtcactat gaccccagac cagaggcagg atgtcgtccg gctcctgcag cttcgcacag     5100

cagagccaga ggtgcgcgcc aagccctaca cgctagagga gttctcctac gactacttca     5160

ggcccccacc caagcacacg ctgagccgtg tcatggtgtc caaggcccgc ggtaaggaca     5220

ggctgtggag ccacacacga gagcccctca agcaggccct gctcaagaag atcctgggca     5280

gtgaagaact ctcccaggaa gcctgcatgg cctttgtagc tgtgctcaag tacatgggcg     5340

actacccatc caagaggatg cgatccgtca atgagctcac tgaccagatc tttgagtggg     5400

cactcaaggc tgagcccctc aaggatgagg cctacgtgca gatcctgaag cagctgactg     5460

acaatcacat caggtacagc gaagagaggg gctgggaact gctgtggctg tgcacgggcc     5520

tcttcccgcc cagcaacatc ctcctgcctc atgttcagcg gtttctgcag tcccgcaagc     5580

actgtcctct tgccattgac tgcctgcaga ggctccagaa agccctgaga aatggctccc     5640

ggaagtaccc tccgcacctg gtggaggtgg aggccatcca acataagact acccagatct     5700

tccacaaggt ctacttcccc gatgacacgg acgaggcttt tgaggtggag tccagcacca     5760

aggccaagga cttctgccag aacatcgcca gccggctgct gctcaagtct tccgagggat     5820

tcagcctttt tgtcaaaatc gcagataagg tcatcagcgt cccagagaat gatttcttct     5880

ttgactttgt ccgacacctg acagactgga taaagaaagc acggcccatc aaggacggaa     5940

tcgtgccctc actaacctac caggtgttct tcatgaagaa gctgtggacc accacagtgc     6000

cgggcaagga ccccatggct gactccatct tccactatta ccaggaactg cccaaatatc     6060

tccgaggcta ccacaagtgc acccgggagg aggtgctgca gctgggcgca ctcatctaca     6120

gggtcaagtt tgaggaggac aaatcctact tccctagcat ccccaagttg ctgagggagc     6180

tggtacccca ggacctaatc cggcaggtct cacctgatga ctggaaacgg tctattgtcg     6240

cctacttcaa caaacatgcg gggaagtcca aggaggaagc caagctggcc ttcctcaaac     6300

tcatcttcaa gtggcccacc tttggctcag ccttctttga ggtgaagcaa actacagaac     6360

caaacttccc agagattctc ttaattgcca tcaacaagta cggggtcagc ctcatcgatc     6420

ccagaaccaa ggacatcctg actactcacc ccttcaccaa gatctccaac tggagtagtg     6480

gcaacaccta cttccacatc accattggga acttggtccg tgggagcaaa ctgctctgtg     6540

agacatcgct gggatacaaa atggatgatc ttctgacttc ctacatcagc cagatgctca     6600

cagccatgag caagcagagg aactccagga gtggaaggtg aacctcagag gagacgctgg     6660

ctcaggcctt ggccctctag gcagggaagc tggactgacc atatctgctg ggcatctgat     6720

ctgcctgcca cgaggtccag actcttctgc atccacctat ggcatctggg tttgctgtca     6780

ccctactttg ttgtggcctt cctggtgtaa gagtctgtgt tccttggtca cctctcctga     6840

ttcagaccag ctccatcaag caacctcttt tgactttctg tatatggatg gcacagagga     6900

atcaaggaca acttagctct ctgcatactt ggaacaacca aactatttgt acattgaacg     6960

gatgctctga aacccaaggg actgggctca gggtcctcag cactggcccc tgtcataagc     7020

actaccacta aggactctct ggaggactcc tcagtatcat ctgctccagg aagcccccta     7080

gactacctcc tgagtctgga caaagcctcc tgattctacc tggatcactc ctgttatgtg     7140

acagttatgt ggtgggtccc tgctaaaatc tccctgacca cctgagggca taaagcatgt     7200

gtcttattct ctgg                                                       7214


<210>  10
<211>  2172
<212>  PRT
<213>  Mus musculus

<400>  10

Met Asp Leu Lys Ser Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val 
1               5                   10                  15      


Val Lys Leu Cys Asp Ser Gly Gln Ile Gln Val Val Asp Asp Glu Asp 
            20                  25                  30          


Asn Glu His Trp Ile Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met 
        35                  40                  45              


His Pro Thr Ser Val His Gly Val Glu Asp Met Ile Arg Leu Gly Asp 
    50                  55                  60                  


Leu Asn Glu Ala Gly Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp 
65                  70                  75                  80  


His Leu Ile Tyr Thr Ser Cys Gly Gly Arg Thr Tyr Thr Gly Ser Ile 
                85                  90                  95      


Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser Ile Tyr Ser Pro Glu 
            100                 105                 110         


His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly Glu Met Pro Pro His 
        115                 120                 125             


Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn Met Lys Arg Asn Asn 
    130                 135                 140                 


Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr 
145                 150                 155                 160 


Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala Ala Ile Ser Gly Gln 
                165                 170                 175     


His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala Thr Pro Ile Leu Glu 
            180                 185                 190         


Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp Asn Ser Ser Arg Phe 
        195                 200                 205             


Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg Gly Ala Ile Glu Gly 
    210                 215                 220                 


Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser Arg Val Cys Arg Gln 
225                 230                 235                 240 


Ala Pro Asp Glu Arg Asn Tyr His Val Phe Tyr Cys Met Leu Glu Gly 
                245                 250                 255     


Met Asn Glu Glu Glu Lys Lys Lys Leu Gly Leu Gly Gln Ala Ala Asp 
            260                 265                 270         


Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr Cys Glu Gly Arg Val 
        275                 280                 285             


Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala Met Lys Val Leu Met 
    290                 295                 300                 


Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys Leu Leu Ala Ala Ile 
305                 310                 315                 320 


Leu His Met Gly Asn Leu Gln Tyr Glu Ala Arg Thr Phe Glu Asn Leu 
                325                 330                 335     


Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu Ala Thr Ala Ala Ser 
            340                 345                 350         


Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser Cys Leu Thr Ser Arg 
        355                 360                 365             


Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr Pro Leu Ser Arg Glu 
    370                 375                 380                 


Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys Gly Ile Tyr Gly Arg 
385                 390                 395                 400 


Leu Phe Val Trp Ile Val Glu Lys Ile Asn Ala Ala Ile Tyr Lys Pro 
                405                 410                 415     


Pro Pro Leu Glu Val Lys Asn Ser Arg Arg Ser Ile Gly Leu Leu Asp 
            420                 425                 430         


Ile Phe Gly Phe Glu Asn Phe Thr Val Asn Ser Phe Glu Gln Leu Cys 
        435                 440                 445             


Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe Phe Val Arg His Val 
    450                 455                 460                 


Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu Ser Ile Asp Trp Leu 
465                 470                 475                 480 


His Ile Glu Phe Thr Asp Asn Gln Glu Ala Leu Asp Met Ile Ala Asn 
                485                 490                 495     


Arg Pro Met Asn Val Ile Ser Leu Ile Asp Glu Glu Ser Lys Phe Pro 
            500                 505                 510         


Lys Gly Thr Asp Ala Thr Met Leu His Lys Leu Asn Ser Gln His Lys 
        515                 520                 525             


Leu Asn Ala Asn Tyr Val Pro Pro Lys Asn Ser His Glu Thr Gln Phe 
    530                 535                 540                 


Gly Ile Asn His Phe Ala Gly Val Val Tyr Tyr Glu Ser Gln Gly Phe 
545                 550                 555                 560 


Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp Ile Ile Gln Leu Val 
                565                 570                 575     


His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile Phe Gln Ala Asp Val 
            580                 585                 590         


Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro Thr Leu Ser Ser Gln 
        595                 600                 605             


Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr Leu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu Phe Lys Lys Pro Met 
625                 630                 635                 640 


Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu Arg Tyr Ser Gly Met 
                645                 650                 655     


Met Glu Thr Ile Arg Ile Arg His Ala Gly Tyr Pro Ile Arg Tyr Ser 
            660                 665                 670         


Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu Leu Pro Gly Val Lys 
        675                 680                 685             


Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr Cys Gln Arg Met Ala 
    690                 695                 700                 


Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln Ile Gly Lys Thr Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Asp His His Asp Met Leu Leu Glu Val Glu Arg Asp 
                725                 730                 735     


Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln Lys Val Ile Arg Gly 
            740                 745                 750         


Phe Lys Asp Arg Ser Asn Phe Leu Arg Leu Lys Ser Ala Ala Thr Leu 
        755                 760                 765             


Ile Gln Arg His Trp Arg Gly His His Cys Arg Lys Asn Tyr Glu Leu 
    770                 775                 780                 


Ile Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu His Arg Ser Arg Lys 
785                 790                 795                 800 


Leu His Lys Gln Tyr Arg Leu Ala Arg Gln Arg Ile Ile Glu Phe Gln 
                805                 810                 815     


Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala Phe Arg His Arg Leu 
            820                 825                 830         


Trp Ala Val Ile Thr Val Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg 
        835                 840                 845             


Arg Leu His Arg Arg Leu Arg Val Glu Tyr Gln Arg Arg Leu Glu Ala 
    850                 855                 860                 


Glu Arg Met Arg Leu Ala Glu Glu Glu Lys Leu Arg Lys Glu Met Ser 
865                 870                 875                 880 


Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys His Gln Glu Arg Leu 
                885                 890                 895     


Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu 
            900                 905                 910         


Glu Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln Met Glu Lys Ala Arg 
        915                 920                 925             


His Glu Pro Ile Asn His Ser Asp Met Val Asp Lys Met Phe Gly Phe 
    930                 935                 940                 


Leu Gly Thr Ser Gly Ser Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser 
945                 950                 955                 960 


Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu Met Val Glu Glu Asp 
                965                 970                 975     


Val Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp Glu Glu Asp Leu Ser 
            980                 985                 990         


Glu Tyr Lys Phe Ala Lys Phe Ala  Ala Thr Tyr Phe Gln  Gly Thr Thr 
        995                 1000                 1005             


Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys Gln Pro  Leu Leu Tyr 
    1010                 1015                 1020             


His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala Leu Ala  Val Trp Ile 
    1025                 1030                 1035             


Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro Glu Pro  Lys Tyr His 
    1040                 1045                 1050             


Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile Pro Val  Met Thr Lys 
    1055                 1060                 1065             


Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr Lys Arg  Glu Leu Gln 
    1070                 1075                 1080             


Ala Leu  Gln Gly Glu Gly Glu  Thr Gln Leu Pro Glu  Gly Gln Lys 
    1085                 1090                 1095             


Lys Thr  Ser Val Arg His Lys  Leu Val His Leu Thr  Leu Lys Lys 
    1100                 1105                 1110             


Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys Arg Leu  Asn Asp Gly 
    1115                 1120                 1125             


Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu Glu Asp  Arg Pro Thr 
    1130                 1135                 1140             


Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile Gly Asn  Gly Ile Leu 
    1145                 1150                 1155             


Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys Gln Ile  Ser Lys Gln 
    1160                 1165                 1170             


Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr Ala Arg  Gly Trp Ile 
    1175                 1180                 1185             


Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala Pro Ser  Glu Lys Phe 
    1190                 1195                 1200             


Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly Gly Pro  Pro Gly Tyr 
    1205                 1210                 1215             


Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg Thr Phe  Val Asn Gly 
    1220                 1225                 1230             


Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu Leu Gln  Ala Thr Lys 
    1235                 1240                 1245             


Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr Phe Met  Asp Gly Thr 
    1250                 1255                 1260             


Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr Thr Ala  Arg Glu Leu 
    1265                 1270                 1275             


Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu Lys Asp  Arg Phe Gly 
    1280                 1285                 1290             


Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys Val Ser  Ser Leu Gly 
    1295                 1300                 1305             


Ser Gly  Ser Asp His Val Met  Asp Ala Ile Ser Gln  Cys Glu Gln 
    1310                 1315                 1320             


Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg Asn Ala  Pro Trp Arg 
    1325                 1330                 1335             


Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro Trp His  Asn Pro Ser 
    1340                 1345                 1350             


Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr Gln Gln  Val Val Arg 
    1355                 1360                 1365             


Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu Lys Glu  Asp Asp Leu 
    1370                 1375                 1380             


Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val Asp Tyr  Gly Ser Glu 
    1385                 1390                 1395             


Met Ile  Leu Glu Arg Leu Leu  Ser Leu Val Pro Thr  Tyr Ile Pro 
    1400                 1405                 1410             


Asp Arg  Glu Ile Thr Pro Leu  Lys Asn Leu Glu Lys  Trp Ala Gln 
    1415                 1420                 1425             


Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile Tyr Ala  Gln Arg Arg 
    1430                 1435                 1440             


Thr Asp  Ser Gln Lys Val Lys  Glu Asp Val Val Asn  Tyr Ala Arg 
    1445                 1450                 1455             


Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe Tyr Glu  Ala Tyr Lys 
    1460                 1465                 1470             


Phe Ser  Gly Pro Pro Leu Pro  Lys Ser Asp Val Ile  Val Ala Val 
    1475                 1480                 1485             


Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu Gln Glu  Gln Val Leu 
    1490                 1495                 1500             


Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala Val Ser  Ser Ser Arg 
    1505                 1510                 1515             


Gly Thr  Lys Met Met Ala Pro  Ser Phe Thr Leu Ala  Thr Ile Lys 
    1520                 1525                 1530             


Gly Asp  Glu Tyr Thr Phe Thr  Ser Ser Asn Ala Glu  Asp Ile Arg 
    1535                 1540                 1545             


Asp Leu  Val Val Thr Phe Leu  Glu Gly Leu Arg Lys  Arg Ser Lys 
    1550                 1555                 1560             


Tyr Val  Val Ala Leu Gln Asp  Asn Pro Asn Pro Ala  Gly Glu Glu 
    1565                 1570                 1575             


Ser Gly  Phe Leu Ser Phe Ala  Lys Gly Asp Leu Ile  Ile Leu Asp 
    1580                 1585                 1590             


His Asp  Thr Gly Glu Gln Val  Met Asn Ser Gly Trp  Ala Asn Gly 
    1595                 1600                 1605             


Ile Asn  Glu Arg Thr Lys Gln  Arg Gly Asp Phe Pro  Thr Asp Cys 
    1610                 1615                 1620             


Val Tyr  Val Met Pro Thr Val  Thr Leu Pro Pro Arg  Glu Ile Val 
    1625                 1630                 1635             


Ala Leu  Val Thr Met Thr Pro  Asp Gln Arg Gln Asp  Val Val Arg 
    1640                 1645                 1650             


Leu Leu  Gln Leu Arg Thr Ala  Glu Pro Glu Val Arg  Ala Lys Pro 
    1655                 1660                 1665             


Tyr Thr  Leu Glu Glu Phe Ser  Tyr Asp Tyr Phe Arg  Pro Pro Pro 
    1670                 1675                 1680             


Lys His  Thr Leu Ser Arg Val  Met Val Ser Lys Ala  Arg Gly Lys 
    1685                 1690                 1695             


Asp Arg  Leu Trp Ser His Thr  Arg Glu Pro Leu Lys  Gln Ala Leu 
    1700                 1705                 1710             


Leu Lys  Lys Ile Leu Gly Ser  Glu Glu Leu Ser Gln  Glu Ala Cys 
    1715                 1720                 1725             


Met Ala  Phe Val Ala Val Leu  Lys Tyr Met Gly Asp  Tyr Pro Ser 
    1730                 1735                 1740             


Lys Arg  Met Arg Ser Val Asn  Glu Leu Thr Asp Gln  Ile Phe Glu 
    1745                 1750                 1755             


Trp Ala  Leu Lys Ala Glu Pro  Leu Lys Asp Glu Ala  Tyr Val Gln 
    1760                 1765                 1770             


Ile Leu  Lys Gln Leu Thr Asp  Asn His Ile Arg Tyr  Ser Glu Glu 
    1775                 1780                 1785             


Arg Gly  Trp Glu Leu Leu Trp  Leu Cys Thr Gly Leu  Phe Pro Pro 
    1790                 1795                 1800             


Ser Asn  Ile Leu Leu Pro His  Val Gln Arg Phe Leu  Gln Ser Arg 
    1805                 1810                 1815             


Lys His  Cys Pro Leu Ala Ile  Asp Cys Leu Gln Arg  Leu Gln Lys 
    1820                 1825                 1830             


Ala Leu  Arg Asn Gly Ser Arg  Lys Tyr Pro Pro His  Leu Val Glu 
    1835                 1840                 1845             


Val Glu  Ala Ile Gln His Lys  Thr Thr Gln Ile Phe  His Lys Val 
    1850                 1855                 1860             


Tyr Phe  Pro Asp Asp Thr Asp  Glu Ala Phe Glu Val  Glu Ser Ser 
    1865                 1870                 1875             


Thr Lys  Ala Lys Asp Phe Cys  Gln Asn Ile Ala Ser  Arg Leu Leu 
    1880                 1885                 1890             


Leu Lys  Ser Ser Glu Gly Phe  Ser Leu Phe Val Lys  Ile Ala Asp 
    1895                 1900                 1905             


Lys Val  Ile Ser Val Pro Glu  Asn Asp Phe Phe Phe  Asp Phe Val 
    1910                 1915                 1920             


Arg His  Leu Thr Asp Trp Ile  Lys Lys Ala Arg Pro  Ile Lys Asp 
    1925                 1930                 1935             


Gly Ile  Val Pro Ser Leu Thr  Tyr Gln Val Phe Phe  Met Lys Lys 
    1940                 1945                 1950             


Leu Trp  Thr Thr Thr Val Pro  Gly Lys Asp Pro Met  Ala Asp Ser 
    1955                 1960                 1965             


Ile Phe  His Tyr Tyr Gln Glu  Leu Pro Lys Tyr Leu  Arg Gly Tyr 
    1970                 1975                 1980             


His Lys  Cys Thr Arg Glu Glu  Val Leu Gln Leu Gly  Ala Leu Ile 
    1985                 1990                 1995             


Tyr Arg  Val Lys Phe Glu Glu  Asp Lys Ser Tyr Phe  Pro Ser Ile 
    2000                 2005                 2010             


Pro Lys  Leu Leu Arg Glu Leu  Val Pro Gln Asp Leu  Ile Arg Gln 
    2015                 2020                 2025             


Val Ser  Pro Asp Asp Trp Lys  Arg Ser Ile Val Ala  Tyr Phe Asn 
    2030                 2035                 2040             


Lys His  Ala Gly Lys Ser Lys  Glu Glu Ala Lys Leu  Ala Phe Leu 
    2045                 2050                 2055             


Lys Leu  Ile Phe Lys Trp Pro  Thr Phe Gly Ser Ala  Phe Phe Glu 
    2060                 2065                 2070             


Val Lys  Gln Thr Thr Glu Pro  Asn Phe Pro Glu Ile  Leu Leu Ile 
    2075                 2080                 2085             


Ala Ile  Asn Lys Tyr Gly Val  Ser Leu Ile Asp Pro  Arg Thr Lys 
    2090                 2095                 2100             


Asp Ile  Leu Thr Thr His Pro  Phe Thr Lys Ile Ser  Asn Trp Ser 
    2105                 2110                 2115             


Ser Gly  Asn Thr Tyr Phe His  Ile Thr Ile Gly Asn  Leu Val Arg 
    2120                 2125                 2130             


Gly Ser  Lys Leu Leu Cys Glu  Thr Ser Leu Gly Tyr  Lys Met Asp 
    2135                 2140                 2145             


Asp Leu  Leu Thr Ser Tyr Ile  Ser Gln Met Leu Thr  Ala Met Ser 
    2150                 2155                 2160             


Lys Gln  Arg Asn Ser Arg Ser  Gly Arg 
    2165                 2170         


<210>  11
<211>  7196
<212>  DNA
<213>  Mus musculus

<400>  11
ggcgctaggc tgtgagatca tcagaggact ccgttaccca cacagctgcc agaggggagt       60

tgtcaaagtg aaaccccagg gactgggggt gtagtttgtg gggtcagggg gactatgtat      120

ggatggacct gaagtcaggc caggagtttg atgtgcccat cggggccgtg gtgaagctct      180

gcgactcggg ccagatccag gtggtggatg atgaagacaa tgaacactgg atatcccctc      240

agaatgccac gcacatcaag ccaatgcacc ccacatcggt gcacggcgtg gaggacatga      300

tccgcctggg ggatctcaac gaggcaggca tccttcgaaa ccttctcatt cgctaccggg      360

accacctcat ctatacgtac acaggttcca tcctggtggc cgtgaacccc taccagctgc      420

tctccatcta ctcgccagag cacatccgcc agtacaccaa caagaagata ggggagatgc      480

ccccccacat cttcgccatt gctgacaact gctacttcaa catgaaacgc aacaaccggg      540

accagtgctg tattatcagc ggggagtcgg gagctggcaa gacagagagc acaaagttga      600

tcctgcagtt cctggcagcc atcagtggac agcactcatg gatcgagcag caggtgctgg      660

aggccacccc gatcctggaa gcatttggga acgccaagac catccgcaac gacaactcta      720

gccgctttgg caagtacatt gacatccact ttaacaagcg tggtgccatc gagggcgcca      780

aaatagagca atacctgctg gagaagtcac gtgtctgccg ccaggcccct gacgagagga      840

actatcacgt gttctactgt atgctggagg gcatgaatga ggaggagaag aagaaactgg      900

gcctaggcca ggccgctgac tacaactact tggccatggg taactgcatc acctgtgagg      960

gccgcgtgga cagtcaggag tatgccaaca tccgctctgc catgaaggtt ctcatgttca     1020

cagacacgga gaactgggag atctcgaagc ttctggctgc catcctacac atgggcaatc     1080

tgcagtatga ggcccggaca tttgagaact tggatgcgtg tgaagtcctc ttctccccat     1140

cgctggccac ggcagcttct ctgctcgagg tgaacccccc agacctgatg agctgcctca     1200

ccagccgcac cctcatcacc cgtggggaga cggtgtccac ccctctcagc agggaacagg     1260

cgctggatgt gcgagatgcc tttgtcaagg gcatctatgg gcggctcttt gtgtggattg     1320

tggagaagat caacgcagca atctacaagc caccccccct ggaagtgaag aactctcgcc     1380

ggtccatcgg tctcctggac atctttggat ttgagaactt cactgtgaac agcttcgagc     1440

agctctgcat taactttgcc aatgagcacc tgcagcaatt cttcgtgcgg cacgtgttca     1500

agctggagca ggaggagtac gacctggaga gcatcgactg gttgcacatt gagttcactg     1560

acaaccagga agcactggac atgattgcca accggcctat gaacgtcatc tccctcatcg     1620

atgaggagag caagttcccc aagggcacgg atgccaccat gctgcataag ctgaactcac     1680

agcacaagct caatgccaac tacgtgccac ccaagaacag ccacgagacc cagtttggaa     1740

tcaaccactt tgcgggtgtt gtctattatg agagtcaagg cttcctggag aagaaccgag     1800

acaccctgca tggggacatc atccagctgg tccactcttc ccggaacaag ttcataaagc     1860

agattttcca agctgacgtt gccatgggtg ccgagaccag gaagcgctcg cctacactca     1920

gcagccagtt caagcggtct ctggagctgc tgatgcgcac actgggcgcc tgccagccct     1980

tctttgtgcg ttgtatcaaa cccaatgagt tcaagaagcc catgctcttc gaccggcact     2040

tgtgtgtacg ccagctgcga tattcgggca tgatggagac aatccgcatc cgccacgcag     2100

gctaccccat tcgctacagc tttgtggagt ttgtggagcg ctaccgggta ctgctgcctg     2160

gtgtgaagcc agcatacaag cagggtgacc tccgagggac atgccagcgc atggctgagg     2220

ctgtgctggg cacgcacgat gactggcaga ttggcaaaac caagatcttt ctgaaggacc     2280

accatgacat gttgctggag gtggagcggg acaaggccat cacagacaga gtcattctcc     2340

tccagaaggt tatccggggc ttcaaagaca ggtccaactt cctgagactg aagagtgctg     2400

ccacactgat ccagaggcac tggcggggcc accactgtag gaaaaactat gagctgattc     2460

gtcttggctt cctgcggctg caggccctgc accgctcccg gaagctgcac aagcagtacc     2520

gcctggccag acagcgcata atagagttcc aggcccgctg ccgggcctat ctggtgcgca     2580

aggccttccg ccaccgcctc tgggccgtga tcaccgtgca ggcctatgcc cgaggcatga     2640

ttgcccgccg gctacaccgc cgcctccggg ttgagtacca gcggcgcctc gaggcagaga     2700

ggatgcgtct ggcagaggag gagaaactcc gaaaggagat gagtgccaag aaggccaaag     2760

aggaggctga gcgcaagcat caggagcgcc tggctcagct agcccgcgag gatgcggagc     2820

gggaactgaa ggagaaggag gaggctcgga ggaagaagga actgctggag cagatggaga     2880

aggcccgcca cgaacccatc aaccactcag atatggtgga caagatgttt ggcttcctgg     2940

ggacttcagg cagcctgcca ggccaggaag gccaggcgcc tagtggcttt gaggacctag     3000

agcgcggacg gagggagatg gtggaagagg atgttgacgc tgccctgccc ctgcctgatg     3060

aagacgagga ggacctttct gagtacaaat tcgccaagtt tgctgccacc tacttccagg     3120

gcacaaccac acactcctac acccggaggc ctctcaagca gccgctgctc taccacgacg     3180

atgagggtga ccagctggcg gcgctggctg tctggatcac catcctccgg ttcatggggg     3240

acctcccaga gcccaagtac cacacagcca tgagcgacgg cagtgagaag atcccagtga     3300

tgactaagat ctacgagacc ctaggcaaga agacatataa gagggagctg caggccttgc     3360

agggcgaggg cgagacccag ctccctgagg ggcagaagaa gaccagtgtg agacacaagt     3420

tggtacactt gacactgaag aaaaagtcca aactcacaga agaggtgacc aagaggctga     3480

acgatgggga atccacggta cagggcaaca gcatgctgga ggatcggccc acctcaaatc     3540

tagagaagct gcacttcatc atcggcaacg gcatcctgcg gcctgcgctg cgggacgaga     3600

tttactgcca gatcagtaag cagctcacac acaacccatc caagagcagc tatgccaggg     3660

gctggatcct cgtgtcgctc tgtgtgggct gcttcgcccc ctctgagaag ttcgttaagt     3720

acctgcggaa cttcatccac ggaggcccac ctggctatgc tccttactgt gaggagcgcc     3780

tgaggaggac ctttgtcaac ggaactcgga cacagccacc cagctggctg gagctgcagg     3840

ccaccaagtc caagaagccc atcatgttgc ccgtgacctt catggatggg accaccaaga     3900

ccctgctaac agattcagca actacagcca gggagctgtg caatgctctg gctgacaaga     3960

tctcactcaa ggaccgcttt ggcttctccc tctacatcgc tctgttcgat aaggtgtcct     4020

ccctgggcag cggcagtgac catgtcatgg atgccatctc tcagtgtgag cagtacgcca     4080

aggagcaggg tgctcaggag cgcaacgccc catggaggct cttctttaga aaggaggtct     4140

tcacaccctg gcacaacccc tcggaggaca acgtggccac gaacctcatc taccagcagg     4200

tggtgcgagg agtcaagttt ggggagtaca ggtgtgagaa ggaggacgac ctggctgagc     4260

tggcttctca gcagtacttt gtggactatg gttctgagat gattctggag cgcctgctga     4320

gcctcgtgcc cacttacatc cctgaccgtg agatcacacc gctgaagaat cttgagaagt     4380

gggcacagct ggccattgct gcccacaaga agggaattta tgcccagagg agaactgact     4440

cccagaaggt caaagaggat gtggtcaatt atgcccgttt caagtggccc ttgctcttct     4500

ccaggtttta cgaagcttac aaattctcag gccctcccct ccccaagagc gacgtcatcg     4560

tggctgtcaa ctggacgggt gtgtacttcg tggacgagca ggagcaggtg cttctggagc     4620

tgtccttccc ggagatcatg gctgtgtcca gcagtagggg aacaaagatg atggccccca     4680

gctttaccct ggccaccatc aaaggagatg agtacacctt cacatccagc aatgctgagg     4740

acatccgtga cctggtggtc acctttctgg aggggctacg gaagaggtct aagtatgtgg     4800

tggcactgca ggacaatcct aaccctgctg gtgaggagtc aggcttcctc agcttcgcca     4860

agggagacct catcatcctt gaccatgata ctggtgagca ggtcatgaac tcaggctggg     4920

ccaacggcat caacgagagg accaagcagc gcggcgactt ccccactgac tgtgtatacg     4980

tcatgcccac tgtcaccttg ccaccaaggg agattgtggc cctggtcact atgaccccag     5040

accagaggca ggatgtcgtc cggctcctgc agcttcgcac agcagagcca gaggtgcgcg     5100

ccaagcccta cacgctagag gagttctcct acgactactt caggccccca cccaagcaca     5160

cgctgagccg tgtcatggtg tccaaggccc gcggtaagga caggctgtgg agccacacac     5220

gagagcccct caagcaggcc ctgctcaaga agatcctggg cagtgaagaa ctctcccagg     5280

aagcctgcat ggcctttgta gctgtgctca agtacatggg cgactaccca tccaagagga     5340

tgcgatccgt caatgagctc actgaccaga tctttgagtg ggcactcaag gctgagcccc     5400

tcaaggatga ggcctacgtg cagatcctga agcagctgac tgacaatcac atcaggtaca     5460

gcgaagagag gggctgggaa ctgctgtggc tgtgcacggg cctcttcccg cccagcaaca     5520

tcctcctgcc tcatgttcag cggtttctgc agtcccgcaa gcactgtcct cttgccattg     5580

actgcctgca gaggctccag aaagccctga gaaatggctc ccggaagtac cctccgcacc     5640

tggtggaggt ggaggccatc caacataaga ctacccagat cttccacaag gtctacttcc     5700

ccgatgacac ggacgaggct tttgaggtgg agtccagcac caaggccaag gacttctgcc     5760

agaacatcgc cagccggctg ctgctcaagt cttccgaggg attcagcctt tttgtcaaaa     5820

tcgcagataa ggtcatcagc gtcccagaga atgatttctt ctttgacttt gtccgacacc     5880

tgacagactg gataaagaaa gcacggccca tcaaggacgg aatcgtgccc tcactaacct     5940

accaggtgtt cttcatgaag aagctgtgga ccaccacagt gccgggcaag gaccccatgg     6000

ctgactccat cttccactat taccaggaac tgcccaaata tctccgaggc taccacaagt     6060

gcacccggga ggaggtgctg cagctgggcg cactcatcta cagggtcaag tttgaggagg     6120

acaaatccta cttccctagc atccccaagt tgctgaggga gctggtaccc caggacctaa     6180

tccggcaggt ctcacctgat gactggaaac ggtctattgt cgcctacttc aacaaacatg     6240

cggggaagtc caaggaggaa gccaagctgg ccttcctcaa actcatcttc aagtggccca     6300

cctttggctc agccttcttt gaggtgaagc aaactacaga accaaacttc ccagagattc     6360

tcttaattgc catcaacaag tacggggtca gcctcatcga tcccagaacc aaggacatcc     6420

tgactactca ccccttcacc aagatctcca actggagtag tggcaacacc tacttccaca     6480

tcaccattgg gaacttggtc cgtgggagca aactgctctg tgagacatcg ctgggataca     6540

aaatggatga tcttctgact tcctacatca gccagatgct cacagccatg agcaagcaga     6600

ggaactccag gagtggaagg tgaacctcag aggagacgct ggctcaggcc ttggccctct     6660

aggcagggaa gctggactga ccatatctgc tgggcatctg atctgcctgc cacgaggtcc     6720

agactcttct gcatccacct atggcatctg ggtttgctgt caccctactt tgttgtggcc     6780

ttcctggtgt aagagtctgt gttccttggt cacctctcct gattcagacc agctccatca     6840

agcaacctct tttgactttc tgtatatgga tggcacagag gaatcaagga caacttagct     6900

ctctgcatac ttggaacaac caaactattt gtacattgaa cggatgctct gaaacccaag     6960

ggactgggct cagggtcctc agcactggcc cctgtcataa gcactaccac taaggactct     7020

ctggaggact cctcagtatc atctgctcca ggaagccccc tagactacct cctgagtctg     7080

gacaaagcct cctgattcta cctggatcac tcctgttatg tgacagttat gtggtgggtc     7140

cctgctaaaa tctccctgac cacctgaggg cataaagcat gtgtcttatt ctctgg         7196


<210>  12
<211>  2166
<212>  PRT
<213>  Mus musculus

<400>  12

Met Asp Leu Lys Ser Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val 
1               5                   10                  15      


Val Lys Leu Cys Asp Ser Gly Gln Ile Gln Val Val Asp Asp Glu Asp 
            20                  25                  30          


Asn Glu His Trp Ile Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met 
        35                  40                  45              


His Pro Thr Ser Val His Gly Val Glu Asp Met Ile Arg Leu Gly Asp 
    50                  55                  60                  


Leu Asn Glu Ala Gly Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp 
65                  70                  75                  80  


His Leu Ile Tyr Thr Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro 
                85                  90                  95      


Tyr Gln Leu Leu Ser Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr 
            100                 105                 110         


Asn Lys Lys Ile Gly Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp 
        115                 120                 125             


Asn Cys Tyr Phe Asn Met Lys Arg Asn Asn Arg Asp Gln Cys Cys Ile 
    130                 135                 140                 


Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile 
145                 150                 155                 160 


Leu Gln Phe Leu Ala Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln 
                165                 170                 175     


Gln Val Leu Glu Ala Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys 
            180                 185                 190         


Thr Ile Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile 
        195                 200                 205             


His Phe Asn Lys Arg Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr 
    210                 215                 220                 


Leu Leu Glu Lys Ser Arg Val Cys Arg Gln Ala Pro Asp Glu Arg Asn 
225                 230                 235                 240 


Tyr His Val Phe Tyr Cys Met Leu Glu Gly Met Asn Glu Glu Glu Lys 
                245                 250                 255     


Lys Lys Leu Gly Leu Gly Gln Ala Ala Asp Tyr Asn Tyr Leu Ala Met 
            260                 265                 270         


Gly Asn Cys Ile Thr Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala 
        275                 280                 285             


Asn Ile Arg Ser Ala Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn 
    290                 295                 300                 


Trp Glu Ile Ser Lys Leu Leu Ala Ala Ile Leu His Met Gly Asn Leu 
305                 310                 315                 320 


Gln Tyr Glu Ala Arg Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu 
                325                 330                 335     


Phe Ser Pro Ser Leu Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro 
            340                 345                 350         


Pro Asp Leu Met Ser Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly 
        355                 360                 365             


Glu Thr Val Ser Thr Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg 
    370                 375                 380                 


Asp Ala Phe Val Lys Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val 
385                 390                 395                 400 


Glu Lys Ile Asn Ala Ala Ile Tyr Lys Pro Pro Pro Leu Glu Val Lys 
                405                 410                 415     


Asn Ser Arg Arg Ser Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn 
            420                 425                 430         


Phe Thr Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu 
        435                 440                 445             


His Leu Gln Gln Phe Phe Val Arg His Val Phe Lys Leu Glu Gln Glu 
    450                 455                 460                 


Glu Tyr Asp Leu Glu Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp 
465                 470                 475                 480 


Asn Gln Glu Ala Leu Asp Met Ile Ala Asn Arg Pro Met Asn Val Ile 
                485                 490                 495     


Ser Leu Ile Asp Glu Glu Ser Lys Phe Pro Lys Gly Thr Asp Ala Thr 
            500                 505                 510         


Met Leu His Lys Leu Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Val 
        515                 520                 525             


Pro Pro Lys Asn Ser His Glu Thr Gln Phe Gly Ile Asn His Phe Ala 
    530                 535                 540                 


Gly Val Val Tyr Tyr Glu Ser Gln Gly Phe Leu Glu Lys Asn Arg Asp 
545                 550                 555                 560 


Thr Leu His Gly Asp Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys 
                565                 570                 575     


Phe Ile Lys Gln Ile Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr 
            580                 585                 590         


Arg Lys Arg Ser Pro Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu 
        595                 600                 605             


Leu Leu Met Arg Thr Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys 
    610                 615                 620                 


Ile Lys Pro Asn Glu Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu 
625                 630                 635                 640 


Cys Val Arg Gln Leu Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile 
                645                 650                 655     


Arg His Ala Gly Tyr Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu 
            660                 665                 670         


Arg Tyr Arg Val Leu Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly 
        675                 680                 685             


Asp Leu Arg Gly Thr Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr 
    690                 695                 700                 


His Asp Asp Trp Gln Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His 
705                 710                 715                 720 


His Asp Met Leu Leu Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg 
                725                 730                 735     


Val Ile Leu Leu Gln Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn 
            740                 745                 750         


Phe Leu Arg Leu Lys Ser Ala Ala Thr Leu Ile Gln Arg His Trp Arg 
        755                 760                 765             


Gly His His Cys Arg Lys Asn Tyr Glu Leu Ile Arg Leu Gly Phe Leu 
    770                 775                 780                 


Arg Leu Gln Ala Leu His Arg Ser Arg Lys Leu His Lys Gln Tyr Arg 
785                 790                 795                 800 


Leu Ala Arg Gln Arg Ile Ile Glu Phe Gln Ala Arg Cys Arg Ala Tyr 
                805                 810                 815     


Leu Val Arg Lys Ala Phe Arg His Arg Leu Trp Ala Val Ile Thr Val 
            820                 825                 830         


Gln Ala Tyr Ala Arg Gly Met Ile Ala Arg Arg Leu His Arg Arg Leu 
        835                 840                 845             


Arg Val Glu Tyr Gln Arg Arg Leu Glu Ala Glu Arg Met Arg Leu Ala 
    850                 855                 860                 


Glu Glu Glu Lys Leu Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu 
865                 870                 875                 880 


Glu Ala Glu Arg Lys His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu 
                885                 890                 895     


Asp Ala Glu Arg Glu Leu Lys Glu Lys Glu Glu Ala Arg Arg Lys Lys 
            900                 905                 910         


Glu Leu Leu Glu Gln Met Glu Lys Ala Arg His Glu Pro Ile Asn His 
        915                 920                 925             


Ser Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Ser 
    930                 935                 940                 


Leu Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu 
945                 950                 955                 960 


Arg Gly Arg Arg Glu Met Val Glu Glu Asp Val Asp Ala Ala Leu Pro 
                965                 970                 975     


Leu Pro Asp Glu Asp Glu Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys 
            980                 985                 990         


Phe Ala Ala Thr Tyr Phe Gln Gly  Thr Thr Thr His Ser  Tyr Thr Arg 
        995                 1000                 1005             


Arg Pro  Leu Lys Gln Pro Leu  Leu Tyr His Asp Asp  Glu Gly Asp 
    1010                 1015                 1020             


Gln Leu  Ala Ala Leu Ala Val  Trp Ile Thr Ile Leu  Arg Phe Met 
    1025                 1030                 1035             


Gly Asp  Leu Pro Glu Pro Lys  Tyr His Thr Ala Met  Ser Asp Gly 
    1040                 1045                 1050             


Ser Glu  Lys Ile Pro Val Met  Thr Lys Ile Tyr Glu  Thr Leu Gly 
    1055                 1060                 1065             


Lys Lys  Thr Tyr Lys Arg Glu  Leu Gln Ala Leu Gln  Gly Glu Gly 
    1070                 1075                 1080             


Glu Thr  Gln Leu Pro Glu Gly  Gln Lys Lys Thr Ser  Val Arg His 
    1085                 1090                 1095             


Lys Leu  Val His Leu Thr Leu  Lys Lys Lys Ser Lys  Leu Thr Glu 
    1100                 1105                 1110             


Glu Val  Thr Lys Arg Leu Asn  Asp Gly Glu Ser Thr  Val Gln Gly 
    1115                 1120                 1125             


Asn Ser  Met Leu Glu Asp Arg  Pro Thr Ser Asn Leu  Glu Lys Leu 
    1130                 1135                 1140             


His Phe  Ile Ile Gly Asn Gly  Ile Leu Arg Pro Ala  Leu Arg Asp 
    1145                 1150                 1155             


Glu Ile  Tyr Cys Gln Ile Ser  Lys Gln Leu Thr His  Asn Pro Ser 
    1160                 1165                 1170             


Lys Ser  Ser Tyr Ala Arg Gly  Trp Ile Leu Val Ser  Leu Cys Val 
    1175                 1180                 1185             


Gly Cys  Phe Ala Pro Ser Glu  Lys Phe Val Lys Tyr  Leu Arg Asn 
    1190                 1195                 1200             


Phe Ile  His Gly Gly Pro Pro  Gly Tyr Ala Pro Tyr  Cys Glu Glu 
    1205                 1210                 1215             


Arg Leu  Arg Arg Thr Phe Val  Asn Gly Thr Arg Thr  Gln Pro Pro 
    1220                 1225                 1230             


Ser Trp  Leu Glu Leu Gln Ala  Thr Lys Ser Lys Lys  Pro Ile Met 
    1235                 1240                 1245             


Leu Pro  Val Thr Phe Met Asp  Gly Thr Thr Lys Thr  Leu Leu Thr 
    1250                 1255                 1260             


Asp Ser  Ala Thr Thr Ala Arg  Glu Leu Cys Asn Ala  Leu Ala Asp 
    1265                 1270                 1275             


Lys Ile  Ser Leu Lys Asp Arg  Phe Gly Phe Ser Leu  Tyr Ile Ala 
    1280                 1285                 1290             


Leu Phe  Asp Lys Val Ser Ser  Leu Gly Ser Gly Ser  Asp His Val 
    1295                 1300                 1305             


Met Asp  Ala Ile Ser Gln Cys  Glu Gln Tyr Ala Lys  Glu Gln Gly 
    1310                 1315                 1320             


Ala Gln  Glu Arg Asn Ala Pro  Trp Arg Leu Phe Phe  Arg Lys Glu 
    1325                 1330                 1335             


Val Phe  Thr Pro Trp His Asn  Pro Ser Glu Asp Asn  Val Ala Thr 
    1340                 1345                 1350             


Asn Leu  Ile Tyr Gln Gln Val  Val Arg Gly Val Lys  Phe Gly Glu 
    1355                 1360                 1365             


Tyr Arg  Cys Glu Lys Glu Asp  Asp Leu Ala Glu Leu  Ala Ser Gln 
    1370                 1375                 1380             


Gln Tyr  Phe Val Asp Tyr Gly  Ser Glu Met Ile Leu  Glu Arg Leu 
    1385                 1390                 1395             


Leu Ser  Leu Val Pro Thr Tyr  Ile Pro Asp Arg Glu  Ile Thr Pro 
    1400                 1405                 1410             


Leu Lys  Asn Leu Glu Lys Trp  Ala Gln Leu Ala Ile  Ala Ala His 
    1415                 1420                 1425             


Lys Lys  Gly Ile Tyr Ala Gln  Arg Arg Thr Asp Ser  Gln Lys Val 
    1430                 1435                 1440             


Lys Glu  Asp Val Val Asn Tyr  Ala Arg Phe Lys Trp  Pro Leu Leu 
    1445                 1450                 1455             


Phe Ser  Arg Phe Tyr Glu Ala  Tyr Lys Phe Ser Gly  Pro Pro Leu 
    1460                 1465                 1470             


Pro Lys  Ser Asp Val Ile Val  Ala Val Asn Trp Thr  Gly Val Tyr 
    1475                 1480                 1485             


Phe Val  Asp Glu Gln Glu Gln  Val Leu Leu Glu Leu  Ser Phe Pro 
    1490                 1495                 1500             


Glu Ile  Met Ala Val Ser Ser  Ser Arg Gly Thr Lys  Met Met Ala 
    1505                 1510                 1515             


Pro Ser  Phe Thr Leu Ala Thr  Ile Lys Gly Asp Glu  Tyr Thr Phe 
    1520                 1525                 1530             


Thr Ser  Ser Asn Ala Glu Asp  Ile Arg Asp Leu Val  Val Thr Phe 
    1535                 1540                 1545             


Leu Glu  Gly Leu Arg Lys Arg  Ser Lys Tyr Val Val  Ala Leu Gln 
    1550                 1555                 1560             


Asp Asn  Pro Asn Pro Ala Gly  Glu Glu Ser Gly Phe  Leu Ser Phe 
    1565                 1570                 1575             


Ala Lys  Gly Asp Leu Ile Ile  Leu Asp His Asp Thr  Gly Glu Gln 
    1580                 1585                 1590             


Val Met  Asn Ser Gly Trp Ala  Asn Gly Ile Asn Glu  Arg Thr Lys 
    1595                 1600                 1605             


Gln Arg  Gly Asp Phe Pro Thr  Asp Cys Val Tyr Val  Met Pro Thr 
    1610                 1615                 1620             


Val Thr  Leu Pro Pro Arg Glu  Ile Val Ala Leu Val  Thr Met Thr 
    1625                 1630                 1635             


Pro Asp  Gln Arg Gln Asp Val  Val Arg Leu Leu Gln  Leu Arg Thr 
    1640                 1645                 1650             


Ala Glu  Pro Glu Val Arg Ala  Lys Pro Tyr Thr Leu  Glu Glu Phe 
    1655                 1660                 1665             


Ser Tyr  Asp Tyr Phe Arg Pro  Pro Pro Lys His Thr  Leu Ser Arg 
    1670                 1675                 1680             


Val Met  Val Ser Lys Ala Arg  Gly Lys Asp Arg Leu  Trp Ser His 
    1685                 1690                 1695             


Thr Arg  Glu Pro Leu Lys Gln  Ala Leu Leu Lys Lys  Ile Leu Gly 
    1700                 1705                 1710             


Ser Glu  Glu Leu Ser Gln Glu  Ala Cys Met Ala Phe  Val Ala Val 
    1715                 1720                 1725             


Leu Lys  Tyr Met Gly Asp Tyr  Pro Ser Lys Arg Met  Arg Ser Val 
    1730                 1735                 1740             


Asn Glu  Leu Thr Asp Gln Ile  Phe Glu Trp Ala Leu  Lys Ala Glu 
    1745                 1750                 1755             


Pro Leu  Lys Asp Glu Ala Tyr  Val Gln Ile Leu Lys  Gln Leu Thr 
    1760                 1765                 1770             


Asp Asn  His Ile Arg Tyr Ser  Glu Glu Arg Gly Trp  Glu Leu Leu 
    1775                 1780                 1785             


Trp Leu  Cys Thr Gly Leu Phe  Pro Pro Ser Asn Ile  Leu Leu Pro 
    1790                 1795                 1800             


His Val  Gln Arg Phe Leu Gln  Ser Arg Lys His Cys  Pro Leu Ala 
    1805                 1810                 1815             


Ile Asp  Cys Leu Gln Arg Leu  Gln Lys Ala Leu Arg  Asn Gly Ser 
    1820                 1825                 1830             


Arg Lys  Tyr Pro Pro His Leu  Val Glu Val Glu Ala  Ile Gln His 
    1835                 1840                 1845             


Lys Thr  Thr Gln Ile Phe His  Lys Val Tyr Phe Pro  Asp Asp Thr 
    1850                 1855                 1860             


Asp Glu  Ala Phe Glu Val Glu  Ser Ser Thr Lys Ala  Lys Asp Phe 
    1865                 1870                 1875             


Cys Gln  Asn Ile Ala Ser Arg  Leu Leu Leu Lys Ser  Ser Glu Gly 
    1880                 1885                 1890             


Phe Ser  Leu Phe Val Lys Ile  Ala Asp Lys Val Ile  Ser Val Pro 
    1895                 1900                 1905             


Glu Asn  Asp Phe Phe Phe Asp  Phe Val Arg His Leu  Thr Asp Trp 
    1910                 1915                 1920             


Ile Lys  Lys Ala Arg Pro Ile  Lys Asp Gly Ile Val  Pro Ser Leu 
    1925                 1930                 1935             


Thr Tyr  Gln Val Phe Phe Met  Lys Lys Leu Trp Thr  Thr Thr Val 
    1940                 1945                 1950             


Pro Gly  Lys Asp Pro Met Ala  Asp Ser Ile Phe His  Tyr Tyr Gln 
    1955                 1960                 1965             


Glu Leu  Pro Lys Tyr Leu Arg  Gly Tyr His Lys Cys  Thr Arg Glu 
    1970                 1975                 1980             


Glu Val  Leu Gln Leu Gly Ala  Leu Ile Tyr Arg Val  Lys Phe Glu 
    1985                 1990                 1995             


Glu Asp  Lys Ser Tyr Phe Pro  Ser Ile Pro Lys Leu  Leu Arg Glu 
    2000                 2005                 2010             


Leu Val  Pro Gln Asp Leu Ile  Arg Gln Val Ser Pro  Asp Asp Trp 
    2015                 2020                 2025             


Lys Arg  Ser Ile Val Ala Tyr  Phe Asn Lys His Ala  Gly Lys Ser 
    2030                 2035                 2040             


Lys Glu  Glu Ala Lys Leu Ala  Phe Leu Lys Leu Ile  Phe Lys Trp 
    2045                 2050                 2055             


Pro Thr  Phe Gly Ser Ala Phe  Phe Glu Val Lys Gln  Thr Thr Glu 
    2060                 2065                 2070             


Pro Asn  Phe Pro Glu Ile Leu  Leu Ile Ala Ile Asn  Lys Tyr Gly 
    2075                 2080                 2085             


Val Ser  Leu Ile Asp Pro Arg  Thr Lys Asp Ile Leu  Thr Thr His 
    2090                 2095                 2100             


Pro Phe  Thr Lys Ile Ser Asn  Trp Ser Ser Gly Asn  Thr Tyr Phe 
    2105                 2110                 2115             


His Ile  Thr Ile Gly Asn Leu  Val Arg Gly Ser Lys  Leu Leu Cys 
    2120                 2125                 2130             


Glu Thr  Ser Leu Gly Tyr Lys  Met Asp Asp Leu Leu  Thr Ser Tyr 
    2135                 2140                 2145             


Ile Ser  Gln Met Leu Thr Ala  Met Ser Lys Gln Arg  Asn Ser Arg 
    2150                 2155                 2160             


Ser Gly  Arg 
    2165     


<210>  13
<211>  7361
<212>  DNA
<213>  Mus musculus

<400>  13
agtgcaggct ggacagctgc cctgaacaga aagaaagagt gacccaggga gacaagaaac       60

agagtagccc aagggaagcc cacagcagca gcagatcaag gctcaagctg gagctgaaaa      120

tttgcaggct ccagcctcag cttccagagt cctcctgacc tgtgacccct ggctcctggc      180

tgggaggtgg tgactcggag ggtgtggata aaacccagag ctgtgtctgg tcactccggc      240

aggtgtgctg acgtagaagc atggttattc tgcagaaggg ggactatgta tggatggacc      300

tgaagtcagg ccaggagttt gatgtgccca tcggggccgt ggtgaagctc tgcgactcgg      360

gccagatcca ggtggtggat gatgaagaca atgaacactg gatatcccct cagaatgcca      420

cgcacatcaa gccaatgcac cccacatcgg tgcacggcgt ggaggacatg atccgcctgg      480

gggatctcaa cgaggcaggc atccttcgaa accttctcat tcgctaccgg gaccacctca      540

tctatacgta cacaggttcc atcctggtgg ccgtgaaccc ctaccagctg ctctccatct      600

actcgccaga gcacatccgc cagtacacca acaagaagat aggggagatg cccccccaca      660

tcttcgccat tgctgacaac tgctacttca acatgaaacg caacaaccgg gaccagtgct      720

gtattatcag cggggagtcg ggagctggca agacagagag cacaaagttg atcctgcagt      780

tcctggcagc catcagtgga cagcactcat ggatcgagca gcaggtgctg gaggccaccc      840

cgatcctgga agcatttggg aacgccaaga ccatccgcaa cgacaactct agccgctttg      900

gcaagtacat tgacatccac tttaacaagc gtggtgccat cgagggcgcc aaaatagagc      960

aatacctgct ggagaagtca cgtgtctgcc gccaggcccc tgacgagagg aactatcacg     1020

tgttctactg tatgctggag ggcatgaatg aggaggagaa gaagaaactg ggcctaggcc     1080

aggccgctga ctacaactac ttggccatgg gtaactgcat cacctgtgag ggccgcgtgg     1140

acagtcagga gtatgccaac atccgctctg ccatgaaggt tctcatgttc acagacacgg     1200

agaactggga gatctcgaag cttctggctg ccatcctaca catgggcaat ctgcagtatg     1260

aggcccggac atttgagaac ttggatgcgt gtgaagtcct cttctcccca tcgctggcca     1320

cggcagcttc tctgctcgag gtgaaccccc cagacctgat gagctgcctc accagccgca     1380

ccctcatcac ccgtggggag acggtgtcca cccctctcag cagggaacag gcgctggatg     1440

tgcgagatgc ctttgtcaag ggcatctatg ggcggctctt tgtgtggatt gtggagaaga     1500

tcaacgcagc aatctacaag ccaccccccc tggaagtgaa gaactctcgc cggtccatcg     1560

gtctcctgga catctttgga tttgagaact tcactgtgaa cagcttcgag cagctctgca     1620

ttaactttgc caatgagcac ctgcagcaat tcttcgtgcg gcacgtgttc aagctggagc     1680

aggaggagta cgacctggag agcatcgact ggttgcacat tgagttcact gacaaccagg     1740

aagcactgga catgattgcc aaccggccta tgaacgtcat ctccctcatc gatgaggaga     1800

gcaagttccc caagggcacg gatgccacca tgctgcataa gctgaactca cagcacaagc     1860

tcaatgccaa ctacgtgcca cccaagaaca gccacgagac ccagtttgga atcaaccact     1920

ttgcgggtgt tgtctattat gagagtcaag gcttcctgga gaagaaccga gacaccctgc     1980

atggggacat catccagctg gtccactctt cccggaacaa gttcataaag cagattttcc     2040

aagctgacgt tgccatgggt gccgagacca ggaagcgctc gcctacactc agcagccagt     2100

tcaagcggtc tctggagctg ctgatgcgca cactgggcgc ctgccagccc ttctttgtgc     2160

gttgtatcaa acccaatgag ttcaagaagc ccatgctctt cgaccggcac ttgtgtgtac     2220

gccagctgcg atattcgggc atgatggaga caatccgcat ccgccacgca ggctacccca     2280

ttcgctacag ctttgtggag tttgtggagc gctaccgggt actgctgcct ggtgtgaagc     2340

cagcatacaa gcagggtgac ctccgaggga catgccagcg catggctgag gctgtgctgg     2400

gcacgcacga tgactggcag attggcaaaa ccaagatctt tctgaaggac caccatgaca     2460

tgttgctgga ggtggagcgg gacaaggcca tcacagacag agtcattctc ctccagaagg     2520

ttatccgggg cttcaaagac aggtccaact tcctgagact gaagagtgct gccacactga     2580

tccagaggca ctggcggggc caccactgta ggaaaaacta tgagctgatt cgtcttggct     2640

tcctgcggct gcaggccctg caccgctccc ggaagctgca caagcagtac cgcctggcca     2700

gacagcgcat aatagagttc caggcccgct gccgggccta tctggtgcgc aaggccttcc     2760

gccaccgcct ctgggccgtg atcaccgtgc aggcctatgc ccgaggcatg attgcccgcc     2820

ggctacaccg ccgcctccgg gttgagtacc agcggcgcct cgaggcagag aggatgcgtc     2880

tggcagagga ggagaaactc cgaaaggaga tgagtgccaa gaaggccaaa gaggaggctg     2940

agcgcaagca tcaggagcgc ctggctcagc tagcccgcga ggatgcggag cgggaactga     3000

aggagaagga ggaggctcgg aggaagaagg aactgctgga gcagatggag aaggcccgcc     3060

acgaacccat caaccactca gatatggtgg acaagatgtt tggcttcctg gggacttcag     3120

gcagcctgcc aggccaggaa ggccaggcgc ctagtggctt tgaggaccta gagcgcggac     3180

ggagggagat ggtggaagag gatgttgacg ctgccctgcc cctgcctgat gaagacgagg     3240

aggacctttc tgagtacaaa ttcgccaagt ttgctgccac ctacttccag ggcacaacca     3300

cacactccta cacccggagg cctctcaagc agccgctgct ctaccacgac gatgagggtg     3360

accagctggc ggcgctggct gtctggatca ccatcctccg gttcatgggg gacctcccag     3420

agcccaagta ccacacagcc atgagcgacg gcagtgagaa gatcccagtg atgactaaga     3480

tctacgagac cctaggcaag aagacatata agagggagct gcaggccttg cagggcgagg     3540

gcgagaccca gctccctgag gggcagaaga agaccagtgt gagacacaag ttggtacact     3600

tgacactgaa gaaaaagtcc aaactcacag aagaggtgac caagaggctg aacgatgggg     3660

aatccacggt acagggcaac agcatgctgg aggatcggcc cacctcaaat ctagagaagc     3720

tgcacttcat catcggcaac ggcatcctgc ggcctgcgct gcgggacgag atttactgcc     3780

agatcagtaa gcagctcaca cacaacccat ccaagagcag ctatgccagg ggctggatcc     3840

tcgtgtcgct ctgtgtgggc tgcttcgccc cctctgagaa gttcgttaag tacctgcgga     3900

acttcatcca cggaggccca cctggctatg ctccttactg tgaggagcgc ctgaggagga     3960

cctttgtcaa cggaactcgg acacagccac ccagctggct ggagctgcag gccaccaagt     4020

ccaagaagcc catcatgttg cccgtgacct tcatggatgg gaccaccaag accctgctaa     4080

cagattcagc aactacagcc agggagctgt gcaatgctct ggctgacaag atctcactca     4140

aggaccgctt tggcttctcc ctctacatcg ctctgttcga taaggtgtcc tccctgggca     4200

gcggcagtga ccatgtcatg gatgccatct ctcagtgtga gcagtacgcc aaggagcagg     4260

gtgctcagga gcgcaacgcc ccatggaggc tcttctttag aaaggaggtc ttcacaccct     4320

ggcacaaccc ctcggaggac aacgtggcca cgaacctcat ctaccagcag gtggtgcgag     4380

gagtcaagtt tggggagtac aggtgtgaga aggaggacga cctggctgag ctggcttctc     4440

agcagtactt tgtggactat ggttctgaga tgattctgga gcgcctgctg agcctcgtgc     4500

ccacttacat ccctgaccgt gagatcacac cgctgaagaa tcttgagaag tgggcacagc     4560

tggccattgc tgcccacaag aagggaattt atgcccagag gagaactgac tcccagaagg     4620

tcaaagagga tgtggtcaat tatgcccgtt tcaagtggcc cttgctcttc tccaggtttt     4680

acgaagctta caaattctca ggccctcccc tccccaagag cgacgtcatc gtggctgtca     4740

actggacggg tgtgtacttc gtggacgagc aggagcaggt gcttctggag ctgtccttcc     4800

cggagatcat ggctgtgtcc agcagtaggg gaacaaagat gatggccccc agctttaccc     4860

tggccaccat caaaggagat gagtacacct tcacatccag caatgctgag gacatccgtg     4920

acctggtggt cacctttctg gaggggctac ggaagaggtc taagtatgtg gtggcactgc     4980

aggacaatcc taaccctgct ggtgaggagt caggcttcct cagcttcgcc aagggagacc     5040

tcatcatcct tgaccatgat actggtgagc aggtcatgaa ctcaggctgg gccaacggca     5100

tcaacgagag gaccaagcag cgcggcgact tccccactga ctgtgtatac gtcatgccca     5160

ctgtcacctt gccaccaagg gagattgtgg ccctggtcac tatgacccca gaccagaggc     5220

aggatgtcgt ccggctcctg cagcttcgca cagcagagcc agaggtgcgc gccaagccct     5280

acacgctaga ggagttctcc tacgactact tcaggccccc acccaagcac acgctgagcc     5340

gtgtcatggt gtccaaggcc cgcggtaagg acaggctgtg gagccacaca cgagagcccc     5400

tcaagcaggc cctgctcaag aagatcctgg gcagtgaaga actctcccag gaagcctgca     5460

tggcctttgt agctgtgctc aagtacatgg gcgactaccc atccaagagg atgcgatccg     5520

tcaatgagct cactgaccag atctttgagt gggcactcaa ggctgagccc ctcaaggatg     5580

aggcctacgt gcagatcctg aagcagctga ctgacaatca catcaggtac agcgaagaga     5640

ggggctggga actgctgtgg ctgtgcacgg gcctcttccc gcccagcaac atcctcctgc     5700

ctcatgttca gcggtttctg cagtcccgca agcactgtcc tcttgccatt gactgcctgc     5760

agaggctcca gaaagccctg agaaatggct cccggaagta ccctccgcac ctggtggagg     5820

tggaggccat ccaacataag actacccaga tcttccacaa ggtctacttc cccgatgaca     5880

cggacgaggc ttttgaggtg gagtccagca ccaaggccaa ggacttctgc cagaacatcg     5940

ccagccggct gctgctcaag tcttccgagg gattcagcct ttttgtcaaa atcgcagata     6000

aggtcatcag cgtcccagag aatgatttct tctttgactt tgtccgacac ctgacagact     6060

ggataaagaa agcacggccc atcaaggacg gaatcgtgcc ctcactaacc taccaggtgt     6120

tcttcatgaa gaagctgtgg accaccacag tgccgggcaa ggaccccatg gctgactcca     6180

tcttccacta ttaccaggaa ctgcccaaat atctccgagg ctaccacaag tgcacccggg     6240

aggaggtgct gcagctgggc gcactcatct acagggtcaa gtttgaggag gacaaatcct     6300

acttccctag catccccaag ttgctgaggg agctggtacc ccaggaccta atccggcagg     6360

tctcacctga tgactggaaa cggtctattg tcgcctactt caacaaacat gcggggaagt     6420

ccaaggagga agccaagctg gccttcctca aactcatctt caagtggccc acctttggct     6480

cagccttctt tgaggtgaag caaactacag aaccaaactt cccagagatt ctcttaattg     6540

ccatcaacaa gtacggggtc agcctcatcg atcccagaac caaggacatc ctgactactc     6600

accccttcac caagatctcc aactggagta gtggcaacac ctacttccac atcaccattg     6660

ggaacttggt ccgtgggagc aaactgctct gtgagacatc gctgggatac aaaatggatg     6720

atcttctgac ttcctacatc agccagatgc tcacagccat gagcaagcag aggaactcca     6780

ggagtggaag gtgaacctca gaggagacgc tggctcaggc cttggccctc taggcaggga     6840

agctggactg accatatctg ctgggcatct gatctgcctg ccacgaggtc cagactcttc     6900

tgcatccacc tatggcatct gggtttgctg tcaccctact ttgttgtggc cttcctggtg     6960

taagagtctg tgttccttgg tcacctctcc tgattcagac cagctccatc aagcaacctc     7020

ttttgacttt ctgtatatgg atggcacaga ggaatcaagg acaacttagc tctctgcata     7080

cttggaacaa ccaaactatt tgtacattga acggatgctc tgaaacccaa gggactgggc     7140

tcagggtcct cagcactggc ccctgtcata agcactacca ctaaggactc tctggaggac     7200

tcctcagtat catctgctcc aggaagcccc ctagactacc tcctgagtct ggacaaagcc     7260

tcctgattct acctggatca ctcctgttat gtgacagtta tgtggtgggt ccctgctaaa     7320

atctccctga ccacctgagg gcataaagca tgtgtcttat t                         7361


<210>  14
<211>  2177
<212>  PRT
<213>  Mus musculus

<400>  14

Met Val Ile Leu Gln Lys Gly Asp Tyr Val Trp Met Asp Leu Lys Ser 
1               5                   10                  15      


Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          


Ser Gly Gln Ile Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              


Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  


His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  


Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      


Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         


Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             


Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 


Met Lys Arg Asn Asn Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 


Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     


Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         


Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             


Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 


Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 


Arg Val Cys Arg Gln Ala Pro Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     


Cys Met Leu Glu Gly Met Asn Glu Glu Glu Lys Lys Lys Leu Gly Leu 
            260                 265                 270         


Gly Gln Ala Ala Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             


Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 


Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 


Leu Leu Ala Ala Ile Leu His Met Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     


Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         


Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             


Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 


Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 


Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Glu Lys Ile Asn Ala 
                405                 410                 415     


Ala Ile Tyr Lys Pro Pro Pro Leu Glu Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         


Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Thr Val Asn Ser 
        435                 440                 445             


Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 


Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 


Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Glu Ala Leu 
                485                 490                 495     


Asp Met Ile Ala Asn Arg Pro Met Asn Val Ile Ser Leu Ile Asp Glu 
            500                 505                 510         


Glu Ser Lys Phe Pro Lys Gly Thr Asp Ala Thr Met Leu His Lys Leu 
        515                 520                 525             


Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Val Pro Pro Lys Asn Ser 
    530                 535                 540                 


His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Val Val Tyr Tyr 
545                 550                 555                 560 


Glu Ser Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     


Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         


Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             


Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 


Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 


Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     


Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg His Ala Gly Tyr 
            660                 665                 670         


Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             


Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 


Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 


Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     


Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         


Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Arg Leu Lys 
        755                 760                 765             


Ser Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His His Cys Arg 
    770                 775                 780                 


Lys Asn Tyr Glu Leu Ile Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 


His Arg Ser Arg Lys Leu His Lys Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     


Ile Ile Glu Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         


Phe Arg His Arg Leu Trp Ala Val Ile Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             


Gly Met Ile Ala Arg Arg Leu His Arg Arg Leu Arg Val Glu Tyr Gln 
    850                 855                 860                 


Arg Arg Leu Glu Ala Glu Arg Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 


Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     


His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         


Leu Lys Glu Lys Glu Glu Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             


Met Glu Lys Ala Arg His Glu Pro Ile Asn His Ser Asp Met Val Asp 
    930                 935                 940                 


Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Ser Leu Pro Gly Gln Glu 
945                 950                 955                 960 


Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     


Met Val Glu Glu Asp Val Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         


Glu Glu Asp Leu Ser Glu Tyr Lys  Phe Ala Lys Phe Ala  Ala Thr Tyr 
        995                 1000                 1005             


Phe Gln  Gly Thr Thr Thr His  Ser Tyr Thr Arg Arg  Pro Leu Lys 
    1010                 1015                 1020             


Gln Pro  Leu Leu Tyr His Asp  Asp Glu Gly Asp Gln  Leu Ala Ala 
    1025                 1030                 1035             


Leu Ala  Val Trp Ile Thr Ile  Leu Arg Phe Met Gly  Asp Leu Pro 
    1040                 1045                 1050             


Glu Pro  Lys Tyr His Thr Ala  Met Ser Asp Gly Ser  Glu Lys Ile 
    1055                 1060                 1065             


Pro Val  Met Thr Lys Ile Tyr  Glu Thr Leu Gly Lys  Lys Thr Tyr 
    1070                 1075                 1080             


Lys Arg  Glu Leu Gln Ala Leu  Gln Gly Glu Gly Glu  Thr Gln Leu 
    1085                 1090                 1095             


Pro Glu  Gly Gln Lys Lys Thr  Ser Val Arg His Lys  Leu Val His 
    1100                 1105                 1110             


Leu Thr  Leu Lys Lys Lys Ser  Lys Leu Thr Glu Glu  Val Thr Lys 
    1115                 1120                 1125             


Arg Leu  Asn Asp Gly Glu Ser  Thr Val Gln Gly Asn  Ser Met Leu 
    1130                 1135                 1140             


Glu Asp  Arg Pro Thr Ser Asn  Leu Glu Lys Leu His  Phe Ile Ile 
    1145                 1150                 1155             


Gly Asn  Gly Ile Leu Arg Pro  Ala Leu Arg Asp Glu  Ile Tyr Cys 
    1160                 1165                 1170             


Gln Ile  Ser Lys Gln Leu Thr  His Asn Pro Ser Lys  Ser Ser Tyr 
    1175                 1180                 1185             


Ala Arg  Gly Trp Ile Leu Val  Ser Leu Cys Val Gly  Cys Phe Ala 
    1190                 1195                 1200             


Pro Ser  Glu Lys Phe Val Lys  Tyr Leu Arg Asn Phe  Ile His Gly 
    1205                 1210                 1215             


Gly Pro  Pro Gly Tyr Ala Pro  Tyr Cys Glu Glu Arg  Leu Arg Arg 
    1220                 1225                 1230             


Thr Phe  Val Asn Gly Thr Arg  Thr Gln Pro Pro Ser  Trp Leu Glu 
    1235                 1240                 1245             


Leu Gln  Ala Thr Lys Ser Lys  Lys Pro Ile Met Leu  Pro Val Thr 
    1250                 1255                 1260             


Phe Met  Asp Gly Thr Thr Lys  Thr Leu Leu Thr Asp  Ser Ala Thr 
    1265                 1270                 1275             


Thr Ala  Arg Glu Leu Cys Asn  Ala Leu Ala Asp Lys  Ile Ser Leu 
    1280                 1285                 1290             


Lys Asp  Arg Phe Gly Phe Ser  Leu Tyr Ile Ala Leu  Phe Asp Lys 
    1295                 1300                 1305             


Val Ser  Ser Leu Gly Ser Gly  Ser Asp His Val Met  Asp Ala Ile 
    1310                 1315                 1320             


Ser Gln  Cys Glu Gln Tyr Ala  Lys Glu Gln Gly Ala  Gln Glu Arg 
    1325                 1330                 1335             


Asn Ala  Pro Trp Arg Leu Phe  Phe Arg Lys Glu Val  Phe Thr Pro 
    1340                 1345                 1350             


Trp His  Asn Pro Ser Glu Asp  Asn Val Ala Thr Asn  Leu Ile Tyr 
    1355                 1360                 1365             


Gln Gln  Val Val Arg Gly Val  Lys Phe Gly Glu Tyr  Arg Cys Glu 
    1370                 1375                 1380             


Lys Glu  Asp Asp Leu Ala Glu  Leu Ala Ser Gln Gln  Tyr Phe Val 
    1385                 1390                 1395             


Asp Tyr  Gly Ser Glu Met Ile  Leu Glu Arg Leu Leu  Ser Leu Val 
    1400                 1405                 1410             


Pro Thr  Tyr Ile Pro Asp Arg  Glu Ile Thr Pro Leu  Lys Asn Leu 
    1415                 1420                 1425             


Glu Lys  Trp Ala Gln Leu Ala  Ile Ala Ala His Lys  Lys Gly Ile 
    1430                 1435                 1440             


Tyr Ala  Gln Arg Arg Thr Asp  Ser Gln Lys Val Lys  Glu Asp Val 
    1445                 1450                 1455             


Val Asn  Tyr Ala Arg Phe Lys  Trp Pro Leu Leu Phe  Ser Arg Phe 
    1460                 1465                 1470             


Tyr Glu  Ala Tyr Lys Phe Ser  Gly Pro Pro Leu Pro  Lys Ser Asp 
    1475                 1480                 1485             


Val Ile  Val Ala Val Asn Trp  Thr Gly Val Tyr Phe  Val Asp Glu 
    1490                 1495                 1500             


Gln Glu  Gln Val Leu Leu Glu  Leu Ser Phe Pro Glu  Ile Met Ala 
    1505                 1510                 1515             


Val Ser  Ser Ser Arg Gly Thr  Lys Met Met Ala Pro  Ser Phe Thr 
    1520                 1525                 1530             


Leu Ala  Thr Ile Lys Gly Asp  Glu Tyr Thr Phe Thr  Ser Ser Asn 
    1535                 1540                 1545             


Ala Glu  Asp Ile Arg Asp Leu  Val Val Thr Phe Leu  Glu Gly Leu 
    1550                 1555                 1560             


Arg Lys  Arg Ser Lys Tyr Val  Val Ala Leu Gln Asp  Asn Pro Asn 
    1565                 1570                 1575             


Pro Ala  Gly Glu Glu Ser Gly  Phe Leu Ser Phe Ala  Lys Gly Asp 
    1580                 1585                 1590             


Leu Ile  Ile Leu Asp His Asp  Thr Gly Glu Gln Val  Met Asn Ser 
    1595                 1600                 1605             


Gly Trp  Ala Asn Gly Ile Asn  Glu Arg Thr Lys Gln  Arg Gly Asp 
    1610                 1615                 1620             


Phe Pro  Thr Asp Cys Val Tyr  Val Met Pro Thr Val  Thr Leu Pro 
    1625                 1630                 1635             


Pro Arg  Glu Ile Val Ala Leu  Val Thr Met Thr Pro  Asp Gln Arg 
    1640                 1645                 1650             


Gln Asp  Val Val Arg Leu Leu  Gln Leu Arg Thr Ala  Glu Pro Glu 
    1655                 1660                 1665             


Val Arg  Ala Lys Pro Tyr Thr  Leu Glu Glu Phe Ser  Tyr Asp Tyr 
    1670                 1675                 1680             


Phe Arg  Pro Pro Pro Lys His  Thr Leu Ser Arg Val  Met Val Ser 
    1685                 1690                 1695             


Lys Ala  Arg Gly Lys Asp Arg  Leu Trp Ser His Thr  Arg Glu Pro 
    1700                 1705                 1710             


Leu Lys  Gln Ala Leu Leu Lys  Lys Ile Leu Gly Ser  Glu Glu Leu 
    1715                 1720                 1725             


Ser Gln  Glu Ala Cys Met Ala  Phe Val Ala Val Leu  Lys Tyr Met 
    1730                 1735                 1740             


Gly Asp  Tyr Pro Ser Lys Arg  Met Arg Ser Val Asn  Glu Leu Thr 
    1745                 1750                 1755             


Asp Gln  Ile Phe Glu Trp Ala  Leu Lys Ala Glu Pro  Leu Lys Asp 
    1760                 1765                 1770             


Glu Ala  Tyr Val Gln Ile Leu  Lys Gln Leu Thr Asp  Asn His Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Glu Glu Arg Gly  Trp Glu Leu Leu Trp  Leu Cys Thr 
    1790                 1795                 1800             


Gly Leu  Phe Pro Pro Ser Asn  Ile Leu Leu Pro His  Val Gln Arg 
    1805                 1810                 1815             


Phe Leu  Gln Ser Arg Lys His  Cys Pro Leu Ala Ile  Asp Cys Leu 
    1820                 1825                 1830             


Gln Arg  Leu Gln Lys Ala Leu  Arg Asn Gly Ser Arg  Lys Tyr Pro 
    1835                 1840                 1845             


Pro His  Leu Val Glu Val Glu  Ala Ile Gln His Lys  Thr Thr Gln 
    1850                 1855                 1860             


Ile Phe  His Lys Val Tyr Phe  Pro Asp Asp Thr Asp  Glu Ala Phe 
    1865                 1870                 1875             


Glu Val  Glu Ser Ser Thr Lys  Ala Lys Asp Phe Cys  Gln Asn Ile 
    1880                 1885                 1890             


Ala Ser  Arg Leu Leu Leu Lys  Ser Ser Glu Gly Phe  Ser Leu Phe 
    1895                 1900                 1905             


Val Lys  Ile Ala Asp Lys Val  Ile Ser Val Pro Glu  Asn Asp Phe 
    1910                 1915                 1920             


Phe Phe  Asp Phe Val Arg His  Leu Thr Asp Trp Ile  Lys Lys Ala 
    1925                 1930                 1935             


Arg Pro  Ile Lys Asp Gly Ile  Val Pro Ser Leu Thr  Tyr Gln Val 
    1940                 1945                 1950             


Phe Phe  Met Lys Lys Leu Trp  Thr Thr Thr Val Pro  Gly Lys Asp 
    1955                 1960                 1965             


Pro Met  Ala Asp Ser Ile Phe  His Tyr Tyr Gln Glu  Leu Pro Lys 
    1970                 1975                 1980             


Tyr Leu  Arg Gly Tyr His Lys  Cys Thr Arg Glu Glu  Val Leu Gln 
    1985                 1990                 1995             


Leu Gly  Ala Leu Ile Tyr Arg  Val Lys Phe Glu Glu  Asp Lys Ser 
    2000                 2005                 2010             


Tyr Phe  Pro Ser Ile Pro Lys  Leu Leu Arg Glu Leu  Val Pro Gln 
    2015                 2020                 2025             


Asp Leu  Ile Arg Gln Val Ser  Pro Asp Asp Trp Lys  Arg Ser Ile 
    2030                 2035                 2040             


Val Ala  Tyr Phe Asn Lys His  Ala Gly Lys Ser Lys  Glu Glu Ala 
    2045                 2050                 2055             


Lys Leu  Ala Phe Leu Lys Leu  Ile Phe Lys Trp Pro  Thr Phe Gly 
    2060                 2065                 2070             


Ser Ala  Phe Phe Glu Val Lys  Gln Thr Thr Glu Pro  Asn Phe Pro 
    2075                 2080                 2085             


Glu Ile  Leu Leu Ile Ala Ile  Asn Lys Tyr Gly Val  Ser Leu Ile 
    2090                 2095                 2100             


Asp Pro  Arg Thr Lys Asp Ile  Leu Thr Thr His Pro  Phe Thr Lys 
    2105                 2110                 2115             


Ile Ser  Asn Trp Ser Ser Gly  Asn Thr Tyr Phe His  Ile Thr Ile 
    2120                 2125                 2130             


Gly Asn  Leu Val Arg Gly Ser  Lys Leu Leu Cys Glu  Thr Ser Leu 
    2135                 2140                 2145             


Gly Tyr  Lys Met Asp Asp Leu  Leu Thr Ser Tyr Ile  Ser Gln Met 
    2150                 2155                 2160             


Leu Thr  Ala Met Ser Lys Gln  Arg Asn Ser Arg Ser  Gly Arg 
    2165                 2170                 2175         


<210>  15
<211>  881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
ctgagggaac agagtggcta ttaccaagcc actgccttcc aggacctcct tacccacgtc       60

ctcccaacct cccctgactt tctcagtagc taccgccatc acaccccgac acaggctctt      120

ggcctcactg ccaatctgtg aggtgggtga accacataac cttagatgca cattccaggc      180

tagggcatct gtttctcatg actaaaatga ttagaaagct agcgctggag gacgtctaga      240

gcccaggagt tcaaggctag cctgatcaat agagcaagac tctctaatct caccgtttcc      300

ccctgagagc aatactatgt ttccttcccc aggtcaagcc aattctatca ttagcatcta      360

tcctgaagca gctgtgtaaa tcttgatggt ttggcccagg gccagtggga agcagacaat      420

ccctgctccc catgtgaacc ccctagaatc agtgcagagc accagaacag gctcatgcgg      480

cttctcccag gttgcagatg ctggggggag ctgaggcttg ctgtgcccac cttggggaac      540

ttgctctcct catcgatgag ggagatgacg ttcataggcg ggttggcaat catgtccagt      600

gcttcctggt tgtcagtgaa ctcaatgtgc aaccagtcga tgctctccag gtcgtactcc      660

tcctgctcca gcttgaacac gtgccgcacg aagaattgct gcaggtgctc attggcaaag      720

ttaatgcaga gctgctcgaa gctgcagagg gaagaggacc ttggacatgt ggcgcccaac      780

ttctgccctg tcacccagac ccggctctac ctagatcaca gcttgacaca agactcccat      840

cacgtgggct agggtacaac tatcaagtcc aactcctacg c                          881


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gatgacgttc ataggccggt tgg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
cttgctctcc tcatcgatga ggg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
atgagggaga tgacgttcat agg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
agggagatga cgttcatagg cgg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
caatcatgtc cagtgcttcc tgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ccaaccggcc tatgaacgtc atc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ccctcatcga tgaggagagc aag                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
cctatgaacg tcatctccct cat                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ccgcctatga acgtcatctc cct                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ccaggaagca ctggacatga ttg                                               23


<210>  26
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
tcatcgatga gggagatgac gttcataggc gggttggcaa tcatgtccag tgcttcctgg       60

t                                                                       61


<210>  27
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
accaggaagc actggacatg attgccaacc cgcctatgaa cgtcatctcc ctcatcgatg       60

a                                                                       61


<210>  28
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
aaccaggaag cactggacat gattgccaac cggcctatga acgtcatctc cctcatcgat       60

gaggagagca ag                                                           72


<210>  29
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
aatcaagaag cactggacat gattgccaat cggccvatga acgtcatctc dctcatcgat       60

gaggagagca ag                                                           72


<210>  30
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
acaaccagga agcactggac atgattgcca accggcctat gaacgtcatc tcactcattg       60

atgaagagag caagttcccc aaggtgggca cagcaa                                 96


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gagggaacag agtggctatt ac                                                22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gcgtaggagt tggacttgat ag                                                22


<210>  33
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gaugacguuc auaggcgggu                                                   20


<210>  41
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gacguucaua ggcgggu                                                      17


<210>  42
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
agggagauga cguucauagg                                                   20


<210>  43
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
gagaugacgu ucauagg                                                      17


<210>  44
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
cuugcucucc ucaucgauga                                                   20


<210>  45
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
augagggaga ugacguucau                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
acccgcctat gaacgtcatc                                                   20


<210>  47
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
acccgcctat gaacgtc                                                      17


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
cctatgaacg tcatctccct                                                   20


<210>  49
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
cctatgaacg tcatctc                                                      17


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tcatcgatga ggagagcaag                                                   20


<210>  51
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
ttgctgtgcc caccttgggg aacttgctct cttcatcaat gagtgagatg acgttcatag       60

gccggttggc aatcatgtcc agtgcttcct ggttgt                                 96


<210>  52
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
acactctttc cctacacgac gctcttccga tctcccaggt caagccaatt ctat             54


<210>  53
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
gactggagtt cagacgtgtg ctcttccgat ctcttcgagc agctctgcat ta               52


<210>  54
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
aaccaggaag cactggacat gattgccaac ccgcctatga acgtcatctc cctcatcgat       60

gaggagagca agtt                                                         74


<210>  55
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
aacttgctct cctcatcgat gagggagatg acgttcatag gcgggttggc aatcatgtcc       60

agtgcttcct ggtt                                                         74


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
caatcatgtc aagtgcttcc tgg                                               23


<210>  57
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
aaccaggaag cactggacat gattgccaac cggcctatga acgtcatctc cctcatcgat       60

gaggagagca agtt                                                         74


<210>  58
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
aacttgctct cctcatcgat gagggagatg acgttcatag gccggttggc aatcatgtcc       60

agtgcttcct ggtt                                                         74


<210>  59
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  n is a, c, g, or t

<400>  59
aaycargaag cactggacat gattgccaay cggccnatga acgtcatctc nctcatcgat       60

gaggagagca ag                                                           72


<210>  60
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
ccaggaagca ctggacatga ttgccaaccg gcctatgaac gtcatctccc tcatcgatga       60

ggagagcaag tt                                                           72


<210>  61
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
ccaggaagca ctggacatga ttgccaaccc gcctatgaac gtcactccct catcgatgag       60

gagagcaagt t                                                            71


<210>  62
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
aaccacgaag cactggacat gattgccaac ccgcctatga acgtcatctc cctcatcgat       60

gaggagagca agtt                                                         74


<210>  63
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Asn Gln Glu Ala Leu Asp Met Ile Ala Asn Pro Pro Met Asn Val Ile 
1               5                   10                  15      


Ser Leu Ile Asp Glu Glu Ser Lys 
            20                  


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
cgttcatagg csggttggca atca                                              24


