                         SEQUENCE LISTING

<110>  BioLegend, Inc
 
<120>  COMPOSITIONS AND METHODS INVOLVING SEVERE ACUTE RESPIRATORY 
       SYNDROME CORONAVIRUS 2 RECEPTOR BINDING DOMAIN

<130>  BLD018PCT

<150>  63/175,758
<151>  2021-04-16

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR1

<400>  1

Asp Tyr Ile Met Leu 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR1

<400>  2

Glu Tyr Thr Met His 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR1

<400>  3

Ser Tyr Trp Met His 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR1

<400>  4

Asn Tyr Trp Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR2

<400>  5

Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Asn Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR2

<400>  6

Gly Ile Asn Pro Asn Asn Val Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR2

<400>  7

Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR2

<400>  8

Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  9
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR2

<400>  9

Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3

<400>  10

Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val 
1               5                   10          


<210>  11
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3

<400>  11

Asp Arg Tyr Asp Tyr Thr Val Asp Tyr 
1               5                   


<210>  12
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3

<400>  12

Arg Gly Leu Leu Asn Phe Asp Tyr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3

<400>  13

Arg Gly Leu Met Asn Phe Asp Tyr 
1               5               


<210>  14
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3

<400>  14

Ala Gly Ala Tyr Tyr Arg Tyr Ser Phe Ala Tyr 
1               5                   10      


<210>  15
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  variable heavy chain

<400>  15

Glu Ile Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Asn Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  16

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Val Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Asp Tyr Thr Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  17
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  18
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  19
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Ala Tyr Tyr Arg Tyr Ser Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  20
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  20

Glu Ile Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  21

Glu Ile Gln Met Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable heavy chain

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  23
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR1

<400>  23

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  24
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR1

<400>  24

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  25
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR1

<400>  25

Ser Ala Ser Ser Ser Leu Asn Tyr Met Tyr 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR1

<400>  26

Ser Ala Ser Ser Ser Leu Asn Phe Met 
1               5                   


<210>  27
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR1

<400>  27

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  28
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR1

<400>  28

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  29
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2

<400>  29

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2

<400>  30

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2

<400>  31

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2

<400>  32

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2

<400>  33

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR3

<400>  34

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR3

<400>  35

Leu Gln Tyr Ala Ser Tyr Pro Trp Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR3

<400>  36

Gln Gln Trp Ser Thr Asn Pro Leu Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR3

<400>  37

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR3

<400>  38

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  39
<211>  109
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  variable light chain

<400>  39

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  40
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR3

<400>  41

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  42
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  42

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  43
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  43

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  44
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  44

Gln Thr Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  45
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  45

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Cys Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  46
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  variable light chain

<400>  46

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc polypeptide

<400>  47

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  48
<211>  451
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  heavy chain

<400>  48

Glu Ile Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Asn Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  49
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  49

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  50
<211>  448
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Val Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Asp Tyr Thr Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  51
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  53
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  53

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  54
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  54

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Met Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  55
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  55

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  56
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  56

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Ala Tyr Tyr Arg Tyr Ser Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  57
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  57

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  58
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  58

Glu Ile Gln Leu Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  59
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  59

Glu Ile Gln Met Gln Gln Thr Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met Leu Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Ser Tyr Asn Leu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Ser Tyr Gly Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  60
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  60

Gln Thr Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  61
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Leu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  62
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  62

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Cys Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  63
<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain

<400>  63

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  64
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR1


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is D, E, N or S

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is I, T or W

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is L or H

<400>  64

Xaa Tyr Xaa Met Xaa 
1               5   


<210>  65
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR2


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is N, G, M or E

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is N or D

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Y, N or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Y, N or D

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is G, V or S

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is S, D, E or R

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is S, N or R

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is Y or L

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is L, Q or E

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is G, D or S

<400>  65

Xaa Ile Xaa Pro Xaa Xaa Xaa Xaa Thr Xaa Xaa Asn Xaa Lys Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  66
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  HCDR3


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Y or no amino acid

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Y, R, A or no amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is G or no amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is S, D, L or A

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is S, R, L, M or Y

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is Y or N

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is G, D, R or no amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is G, Y or no amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is Y, T, S or no amino acid

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is F or V

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is D or A

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is V or Y

<400>  66

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  67
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR1


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is S or R

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is A or S

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is S, E, K, Q or T

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is S, E or G

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is L or no amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is V, L or no amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is D, H, A or no amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is N, S, V or no amino acid

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Y, N, T or no amino acid

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is G, I, T or no amino acid

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is L, I, N or S

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is N, S, T or G

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is F or Y

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is M, L or A

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is Y, N or S

<400>  67

Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  68
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LCDR2


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is L, A or R

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is T, A or M

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is S or N

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is N or T

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is L, Q or R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is A, G or D

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is S or P

<400>  68

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  69
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR3


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Q, M, L or A

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Q or L

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is W, S, H or Y

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is S, K, L, A or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is T, E or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is N, V or Y

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is P or H

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is L, Y or W

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is T or V

<400>  69

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  70
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  70
atgggaggga tctggatctt tctcttcctc ctgtcaggaa ctgcaggtgc ccactctgag       60

atccagctgc agcagactgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttattc attcactgac tacatcatgc tctgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaaatatt aatccttact atggtagtac taactacaat      240

ctgaagttca agggcaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

cagctcaaca gtctgacatc tgaggactct gcagtctatt actgtgcaag atactacggt      360

agtagctacg gggggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420


<210>  71
<211>  411
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  71
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccagctgc aacagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaagactt ctggatacac attcactgaa tacaccatgc actgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaggtatt aatcctaaca atgttgatac tagctacaac      240

cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctacatg      300

gagctccgca gcctgacatc tgaggattct gcagtctatt actgtgcaag ggataggtac      360

gactatactg tggactactg gggtcaagga acctcagtca ccgtctcctc a               411


<210>  72
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  72
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtgcaactgc agcagtctgg gcctcagctg gttaggcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcaccagc tactggatgc actgggtgaa acagaggcct      180

ggacaaggtc ttgagtggat tggcatgatt gatccttccg atagtgaaac taggttaaat      240

cagaagttca aggacaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcccgacatc tgaggactct gcggtctatt actgtgcaag aaggggacta      360

ctgaactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  73
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  73
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtgcaactgc agcagtctgg gcctcagctg gttaggcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attcaccagc tactggatgc actgggtgaa acagaggcct      180

ggacaaggtc ttgagtggat tggcatgatt gatccttccg atagtgaaac taggttaaat      240

cagaagttca aggacaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcccgacatc tgaggactct gcggtctatt actgtgcaag aaggggacta      360

atgaactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  74
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  74
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctagca acggtcgtac taactacaat      240

gagaagttca agagcaaggc cacactgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag cgcgggcgcc      360

tactataggt actcttttgc ttactggggc caagggactc tggtcactgt ctctgca         417


<210>  75
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  75
atgggaggga tctggatctt tctcttcctc ctgtcaggaa ctgcaggtgc ccactctgag       60

atccagctgc agcagactgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttattc attcactgac tacatcatgc tctgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaaatatt aatccttact atggtagtac tagctacaat      240

ctgaagttca agggcaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

cagctcaaca gtctgacatc tgaggactct gcagtctatt actgtgcaag atactacggt      360

agtagctacg gggggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420


<210>  76
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  76
atgggaggga tctggatctt tctcttcctc ctgtcaggaa ctgcaggtgc ccactctgag       60

atccagatgc agcagactgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttattc attcactgac tacatcatgc tctgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaaatatt aatccttact atggtagtac tagctacaat      240

ctgaagttca agggcaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

cagctcaaca gtctgacatc tgaggactct gcagtctatt actgtgcaag atactacggt      360

agtagctacg gggggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420


<210>  77
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  77
atgggaggga tctggatctt tctcttcctc ctgtcaggaa ctgcaggtgc ccactctgag       60

atccagatgc agcagactgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttattc attcactgac tacatcatgc tctgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaaatatt aatccttact atggtagtac tagctacaat      240

ctgaagttca agggcaaggc cacattgact gtagacaaat cttccagcac agcctacatg      300

cagctcaaca gtctgacatc tgaggactct gcagtctatt actgtgcaag atactacggt      360

agtagctacg gggggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      420


<210>  78
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  78
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtacaactgc agcagtctgg gcctcagctg gttaggcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attctccaac tactggatgc actgggtgaa acagaggcct      180

ggacaaggtc ttgagtggat tggcatgatt gatccttccg atagtgaaac taggttaaat      240

cagaagttca aggacaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcccgacatc tgaggactct gcggtctatt actgtgcaag aaggggacta      360

ctgaactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  79
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable region

<400>  79
atgggatgga gctgtatcat cctcttcttg gtatcaacag ctacaggtgt ccactcccag       60

gtacaactgc agcagtctgg gcctcagctg gttaggcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggttactc attctccaac tactggatgc actgggtgaa acagaggcct      180

ggacaaggtc ttgagtggat tggcatgatt gatccttccg atagtgaaac taggttaaat      240

cagaagttca aggacaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcccgacatc tgaggactct gcggtctatt actgtgcaag aaggggacta      360

ctgaactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  80
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  80
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  81
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  81
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  82
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  82
atgagggttc ctgctcacgt ttttggcttc ttgttgctct ggtttccagg taccagatgt       60

gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt      120

ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca      180

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa      240

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      300

gaagattttg cagactatta ctgtctacaa tatgctagtt atccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  83
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  83
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt ttaaattaca tgtactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacttcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc ttacaatcaa cagcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta ctaacccgct cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  84
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  84
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt ttaaatttca tgtactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacttcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc ttacaatcaa cagcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta ctaacccgct cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  85
<211>  393
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  85
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      180

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      300

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  86
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  86
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctagca acggtcgtac taactacaat      240

gagaagttca agagcaaggc cacactgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt actgtgcaag cgcgggcgcc      360

tactataggt actcttttgc ttactggggc caagggactc tggtcactgt ctctgca         417


<210>  87
<211>  393
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  87
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      180

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      300

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  88
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  88
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  89
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  89
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

actgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  90
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  90
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

actgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt ccta                                             384


<210>  91
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  91
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt ttaaatttca tgtactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacttcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc ttacaatcaa ctgcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta ctaacccgct cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  92
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  92
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt ttaaatttca tgtactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacttcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc ttacaatcaa ctgcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta ctaacccgct cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  93
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable region

<400>  93
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg      360

tacacgttcg gaggggggac caagctggaa ataaaa                                396


