                               SEQUENCE LISTING

<110> DERMTECH, INC.
 
<120> GENE CLASSIFIERS AND USES THEREOF 

<130> 44503-739.601

<140> PCT/US2022/024488
<141> 2022-04-12

<150> 63/174,345
<151> 2021-04-13

<150> 63/175,514
<151> 2021-04-15

<150> 63/245,118 
<151> 2021-09-16

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 393
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 2
<211> 1132
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210> 3
<211> 1447
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ser Ala Gly Asn Ala Ala Glu Pro Gln Asp Arg Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Cys Ile Gly Ala Pro Gly Arg Pro Ala Gly Gly Gly Arg 
            20                  25                  30          


Arg Arg Arg Thr Gly Gly Leu Arg Arg Ala Ala Ala Pro Asp Arg Asp 
        35                  40                  45              


Tyr Leu His Arg Pro Ser Tyr Cys Asp Ala Ala Phe Ala Leu Glu Gln 
    50                  55                  60                  


Ile Ser Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg 
65                  70                  75                  80  


Ala Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys 
                85                  90                  95      


Asn Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe 
            100                 105                 110         


Ala Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu 
        115                 120                 125             


Trp Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg 
    130                 135                 140                 


Gln Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln 
145                 150                 155                 160 


Thr Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu 
                165                 170                 175     


Gln His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met 
            180                 185                 190         


Tyr Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr 
    210                 215                 220                 


Pro Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys 
225                 230                 235                 240 


Leu Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Pro Leu Arg Trp 
                245                 250                 255     


Thr Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn 
            260                 265                 270         


Tyr Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly 
        275                 280                 285             


His Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys 
    290                 295                 300                 


Pro Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala 
305                 310                 315                 320 


Leu Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His 
                325                 330                 335     


Trp Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly 
            340                 345                 350         


Lys Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr 
        355                 360                 365             


Pro Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His 
    370                 375                 380                 


Ile Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln 
385                 390                 395                 400 


Arg Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr 
                405                 410                 415     


Gln Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys 
            420                 425                 430         


Ser Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu 
        435                 440                 445             


Met Leu Ala Tyr Ala Cys Leu Thr Met Leu Arg Trp Asp Cys Ser Lys 
    450                 455                 460                 


Ser Gln Gly Ala Val Gly Leu Ala Gly Val Leu Leu Val Ala Leu Ser 
465                 470                 475                 480 


Val Ala Ala Gly Leu Gly Leu Cys Ser Leu Ile Gly Ile Ser Phe Asn 
                485                 490                 495     


Ala Ala Thr Thr Gln Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val 
            500                 505                 510         


Asp Asp Val Phe Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn 
        515                 520                 525             


Lys Arg Ile Pro Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr 
    530                 535                 540                 


Gly Ala Ser Val Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe 
545                 550                 555                 560 


Met Ala Ala Leu Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln 
                565                 570                 575     


Ala Ala Val Val Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe 
            580                 585                 590         


Pro Ala Ile Leu Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu 
        595                 600                 605             


Asp Ile Phe Cys Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln 
    610                 615                 620                 


Val Glu Pro Gln Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser 
625                 630                 635                 640 


Pro Pro Pro Pro Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile 
                645                 650                 655     


Thr Met Gln Ser Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr 
            660                 665                 670         


His Val Tyr Tyr Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln 
        675                 680                 685             


Pro Val Thr Val Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser 
    690                 695                 700                 


Thr Ser Ser Thr Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu 
705                 710                 715                 720 


His Cys Leu Glu Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala 
                725                 730                 735     


Glu Lys His Tyr Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val 
            740                 745                 750         


Val Ile Phe Leu Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr 
        755                 760                 765             


Thr Arg Val Arg Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu 
    770                 775                 780                 


Thr Arg Glu Tyr Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe 
785                 790                 795                 800 


Tyr Asn Met Tyr Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln 
                805                 810                 815     


His Leu Leu Tyr Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val 
            820                 825                 830         


Met Leu Glu Glu Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe 
        835                 840                 845             


Arg Asp Trp Leu Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu 
    850                 855                 860                 


Thr Gly Lys Ile Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly 
865                 870                 875                 880 


Val Leu Ala Tyr Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro 
                885                 890                 895     


Ile Asp Ile Ser Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly 
            900                 905                 910         


Ile Ile Asn Pro Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser 
        915                 920                 925             


Asn Asp Pro Val Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His 
    930                 935                 940                 


Arg Pro Glu Trp Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg 
945                 950                 955                 960 


Leu Arg Ile Pro Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe 
                965                 970                 975     


Tyr Leu Asn Gly Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu 
            980                 985                 990         


Lys Val Arg Thr Ile Cys Ser Asn  Tyr Thr Ser Leu Gly  Leu Ser Ser 
        995                 1000                 1005             


Tyr Pro  Asn Gly Tyr Pro Phe  Leu Phe Trp Glu Gln  Tyr Ile Gly 
    1010                 1015                 1020             


Leu Arg  His Trp Leu Leu Leu  Phe Ile Ser Val Val  Leu Ala Cys 
    1025                 1030                 1035             


Thr Phe  Leu Val Cys Ala Val  Phe Leu Leu Asn Pro  Trp Thr Ala 
    1040                 1045                 1050             


Gly Ile  Ile Val Met Val Leu  Ala Leu Met Thr Val  Glu Leu Phe 
    1055                 1060                 1065             


Gly Met  Met Gly Leu Ile Gly  Ile Lys Leu Ser Ala  Val Pro Val 
    1070                 1075                 1080             


Val Ile  Leu Ile Ala Ser Val  Gly Ile Gly Val Glu  Phe Thr Val 
    1085                 1090                 1095             


His Val  Ala Leu Ala Phe Leu  Thr Ala Ile Gly Asp  Lys Asn Arg 
    1100                 1105                 1110             


Arg Ala  Val Leu Ala Leu Glu  His Met Phe Ala Pro  Val Leu Asp 
    1115                 1120                 1125             


Gly Ala  Val Ser Thr Leu Leu  Gly Val Leu Met Leu  Ala Gly Ser 
    1130                 1135                 1140             


Glu Phe  Asp Phe Ile Val Arg  Tyr Phe Phe Ala Val  Leu Ala Ile 
    1145                 1150                 1155             


Leu Thr  Ile Leu Gly Val Leu  Asn Gly Leu Val Leu  Leu Pro Val 
    1160                 1165                 1170             


Leu Leu  Ser Phe Phe Gly Pro  Tyr Pro Glu Val Ser  Pro Ala Asn 
    1175                 1180                 1185             


Gly Leu  Asn Arg Leu Pro Thr  Pro Ser Pro Glu Pro  Pro Pro Ser 
    1190                 1195                 1200             


Val Val  Arg Phe Ala Met Pro  Pro Gly His Thr His  Ser Gly Ser 
    1205                 1210                 1215             


Asp Ser  Ser Asp Ser Glu Tyr  Ser Ser Gln Thr Thr  Val Ser Gly 
    1220                 1225                 1230             


Leu Ser  Glu Glu Leu Arg His  Tyr Glu Ala Gln Gln  Gly Ala Gly 
    1235                 1240                 1245             


Gly Pro  Ala His Gln Val Ile  Val Glu Ala Thr Glu  Asn Pro Val 
    1250                 1255                 1260             


Phe Ala  His Ser Thr Val Val  His Pro Glu Ser Arg  His His Pro 
    1265                 1270                 1275             


Pro Ser  Asn Pro Arg Gln Gln  Pro His Leu Asp Ser  Gly Ser Leu 
    1280                 1285                 1290             


Pro Pro  Gly Arg Gln Gly Gln  Gln Pro Arg Arg Asp  Pro Pro Arg 
    1295                 1300                 1305             


Glu Gly  Leu Trp Pro Pro Pro  Tyr Arg Pro Arg Arg  Asp Ala Phe 
    1310                 1315                 1320             


Glu Ile  Ser Thr Glu Gly His  Ser Gly Pro Ser Asn  Arg Ala Arg 
    1325                 1330                 1335             


Trp Gly  Pro Arg Gly Ala Arg  Ser His Asn Pro Arg  Asn Pro Ala 
    1340                 1345                 1350             


Ser Thr  Ala Met Gly Ser Ser  Val Pro Gly Tyr Cys  Gln Pro Ile 
    1355                 1360                 1365             


Thr Thr  Val Thr Ala Ser Ala  Ser Val Thr Val Ala  Val His Pro 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Pro Gly  Arg Asn Pro Arg Gly  Gly Leu Cys 
    1385                 1390                 1395             


Pro Gly  Tyr Pro Glu Thr Asp  His Gly Leu Phe Glu  Asp Pro His 
    1400                 1405                 1410             


Val Pro  Phe His Val Arg Cys  Glu Arg Arg Asp Ser  Lys Val Glu 
    1415                 1420                 1425             


Val Ile  Glu Leu Gln Asp Val  Glu Cys Glu Glu Arg  Pro Arg Gly 
    1430                 1435                 1440             


Ser Ser  Ser Asn 
    1445         


<210> 4
<211> 1296
<212> PRT
<213> Homo sapiens

<400> 4
Met Phe Asn Pro Gln Leu Met Ile Gln Thr Pro Lys Glu Glu Gly Ala 
1               5                   10                  15      


Asn Val Leu Thr Thr Glu Ala Leu Leu Gln His Leu Asp Ser Ala Leu 
            20                  25                  30          


Gln Ala Ser Arg Val His Val Tyr Met Tyr Asn Arg Gln Trp Lys Leu 
        35                  40                  45              


Glu His Leu Cys Tyr Lys Ser Gly Glu Leu Ile Thr Glu Thr Gly Tyr 
    50                  55                  60                  


Met Asp Gln Ile Ile Glu Tyr Leu Tyr Pro Cys Leu Ile Ile Thr Pro 
65                  70                  75                  80  


Leu Asp Cys Phe Trp Glu Gly Ala Lys Leu Gln Ser Gly Thr Ala Tyr 
                85                  90                  95      


Leu Leu Gly Lys Pro Pro Leu Arg Trp Thr Asn Phe Asp Pro Leu Glu 
            100                 105                 110         


Phe Leu Glu Glu Leu Lys Lys Ile Asn Tyr Gln Val Asp Ser Trp Glu 
        115                 120                 125             


Glu Met Leu Asn Lys Ala Glu Val Gly His Gly Tyr Met Asp Arg Pro 
    130                 135                 140                 


Cys Leu Asn Pro Ala Asp Pro Asp Cys Pro Ala Thr Ala Pro Asn Lys 
145                 150                 155                 160 


Asn Ser Thr Lys Pro Leu Asp Met Ala Leu Val Leu Asn Gly Gly Cys 
                165                 170                 175     


His Gly Leu Ser Arg Lys Tyr Met His Trp Gln Glu Glu Leu Ile Val 
            180                 185                 190         


Gly Gly Thr Val Lys Asn Ser Thr Gly Lys Leu Val Ser Ala His Ala 
        195                 200                 205             


Leu Gln Thr Met Phe Gln Leu Met Thr Pro Lys Gln Met Tyr Glu His 
    210                 215                 220                 


Phe Lys Gly Tyr Glu Tyr Val Ser His Ile Asn Trp Asn Glu Asp Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Leu Glu Ala Trp Gln Arg Thr Tyr Val Glu Val Val 
                245                 250                 255     


His Gln Ser Val Ala Gln Asn Ser Thr Gln Lys Val Leu Ser Phe Thr 
            260                 265                 270         


Thr Thr Thr Leu Asp Asp Ile Leu Lys Ser Phe Ser Asp Val Ser Val 
        275                 280                 285             


Ile Arg Val Ala Ser Gly Tyr Leu Leu Met Leu Ala Tyr Ala Cys Leu 
    290                 295                 300                 


Thr Met Leu Arg Trp Asp Cys Ser Lys Ser Gln Gly Ala Val Gly Leu 
305                 310                 315                 320 


Ala Gly Val Leu Leu Val Ala Leu Ser Val Ala Ala Gly Leu Gly Leu 
                325                 330                 335     


Cys Ser Leu Ile Gly Ile Ser Phe Asn Ala Ala Thr Thr Gln Val Leu 
            340                 345                 350         


Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe Leu Leu Ala 
        355                 360                 365             


His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro Phe Glu Asp 
    370                 375                 380                 


Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val Ala Leu Thr 
385                 390                 395                 400 


Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu Ile Pro Ile 
                405                 410                 415     


Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val Val Val Phe 
            420                 425                 430         


Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu Ser Met Asp 
        435                 440                 445             


Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys Cys Phe Thr 
    450                 455                 460                 


Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln Ala Tyr Thr 
465                 470                 475                 480 


Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro Tyr Ser Ser 
                485                 490                 495     


His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser Thr Val Gln 
            500                 505                 510         


Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr Thr Thr Ala 
        515                 520                 525             


Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val Thr Gln Asp 
    530                 535                 540                 


Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr Arg Asp Leu 
545                 550                 555                 560 


Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu Pro Pro Cys 
                565                 570                 575     


Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr Ala Pro Phe 
            580                 585                 590         


Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu Phe Leu Gly 
        595                 600                 605             


Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg Asp Gly Leu 
    610                 615                 620                 


Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr Asp Phe Ile 
625                 630                 635                 640 


Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr Ile Val Thr 
                645                 650                 655     


Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr Asp Leu His 
            660                 665                 670         


Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu Asn Lys Gln 
        675                 680                 685             


Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu Gln Gly Leu 
    690                 695                 700                 


Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile Met Pro Asn 
705                 710                 715                 720 


Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr Lys Leu Leu 
                725                 730                 735     


Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser Gln Leu Thr 
            740                 745                 750         


Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro Ser Ala Phe 
        755                 760                 765             


Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val Ala Tyr Ala 
    770                 775                 780                 


Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp Val His Asp 
785                 790                 795                 800 


Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro Ala Ala Glu 
                805                 810                 815     


Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly Leu Arg Asp 
            820                 825                 830         


Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr Ile Cys Ser 
        835                 840                 845             


Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly Tyr Pro Phe 
    850                 855                 860                 


Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu Leu Leu Phe 
865                 870                 875                 880 


Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala Val Phe Leu 
                885                 890                 895     


Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu Ala Leu Met 
            900                 905                 910         


Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile Lys Leu Ser 
        915                 920                 925             


Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu 
    930                 935                 940                 


Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile Gly Asp Lys 
945                 950                 955                 960 


Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala Pro Val Leu 
                965                 970                 975     


Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu Ala Gly Ser 
            980                 985                 990         


Glu Phe Asp Phe Ile Val Arg Tyr  Phe Phe Ala Val Leu  Ala Ile Leu 
        995                 1000                 1005             


Thr Ile  Leu Gly Val Leu Asn  Gly Leu Val Leu Leu  Pro Val Leu 
    1010                 1015                 1020             


Leu Ser  Phe Phe Gly Pro Tyr  Pro Glu Val Ser Pro  Ala Asn Gly 
    1025                 1030                 1035             


Leu Asn  Arg Leu Pro Thr Pro  Ser Pro Glu Pro Pro  Pro Ser Val 
    1040                 1045                 1050             


Val Arg  Phe Ala Met Pro Pro  Gly His Thr His Ser  Gly Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Glu Tyr Ser  Ser Gln Thr Thr Val  Ser Gly Leu 
    1070                 1075                 1080             


Ser Glu  Glu Leu Arg His Tyr  Glu Ala Gln Gln Gly  Ala Gly Gly 
    1085                 1090                 1095             


Pro Ala  His Gln Val Ile Val  Glu Ala Thr Glu Asn  Pro Val Phe 
    1100                 1105                 1110             


Ala His  Ser Thr Val Val His  Pro Glu Ser Arg His  His Pro Pro 
    1115                 1120                 1125             


Ser Asn  Pro Arg Gln Gln Pro  His Leu Asp Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Pro Gly  Arg Gln Gly Gln Gln  Pro Arg Arg Asp Pro  Pro Arg Glu 
    1145                 1150                 1155             


Gly Leu  Trp Pro Pro Pro Tyr  Arg Pro Arg Arg Asp  Ala Phe Glu 
    1160                 1165                 1170             


Ile Ser  Thr Glu Gly His Ser  Gly Pro Ser Asn Arg  Ala Arg Trp 
    1175                 1180                 1185             


Gly Pro  Arg Gly Ala Arg Ser  His Asn Pro Arg Asn  Pro Ala Ser 
    1190                 1195                 1200             


Thr Ala  Met Gly Ser Ser Val  Pro Gly Tyr Cys Gln  Pro Ile Thr 
    1205                 1210                 1215             


Thr Val  Thr Ala Ser Ala Ser  Val Thr Val Ala Val  His Pro Pro 
    1220                 1225                 1230             


Pro Val  Pro Gly Pro Gly Arg  Asn Pro Arg Gly Gly  Leu Cys Pro 
    1235                 1240                 1245             


Gly Tyr  Pro Glu Thr Asp His  Gly Leu Phe Glu Asp  Pro His Val 
    1250                 1255                 1260             


Pro Phe  His Val Arg Cys Glu  Arg Arg Asp Ser Lys  Val Glu Val 
    1265                 1270                 1275             


Ile Glu  Leu Gln Asp Val Glu  Cys Glu Glu Arg Pro  Arg Gly Ser 
    1280                 1285                 1290             


Ser Ser  Asn 
    1295     


<210> 5
<211> 156
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210> 6
<211> 103
<212> PRT
<213> Homo sapiens

<400> 6
Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu 
1               5                   10                  15      


His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro 
            20                  25                  30          


Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu 
        35                  40                  45              


His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu 
    50                  55                  60                  


Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr 
65                  70                  75                  80  


Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Glu Gly Pro Ser 
            100             


<210> 7
<211> 45
<212> DNA
<213> Homo sapiens

<400> 7
caggtcatga tgatgggcag cgcccgagtg gcggagctgc tgctg                       45


<210> 8
<211> 45
<212> DNA
<213> Homo sapiens

<400> 8
cggcgcggag cccaactgcg ccgaccccgc cactctcacc cgacc                       45


<210> 9
<211> 44
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (29)..(29)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (37)..(37)
<223> a, c, t, g, unknown or other

<400> 9
gggcccggag ggggctgggc cggggaccng ggagggntcg ggac                        44


<210> 10
<211> 108
<212> DNA
<213> Homo sapiens

<400> 10
cgcgtccgcg ccatggccat ctacaagcag tcacagcaca tgacggaggt tgtgaggcgc       60

tgcccccacc atgagcgctg ctcagatagc gatggtgagc agctgggg                   108


<210> 11
<211> 106
<212> DNA
<213> Homo sapiens

<400> 11
tgactgtacc accatccact acaactacat gtgtaacagt tcctgcatgg gcggcatgaa       60

ccggaggccc atcctcacca tcatcacact ggaagactcc aggtca                     106


<210> 12
<211> 103
<212> DNA
<213> Homo sapiens

<400> 12
tgggacggaa cagctttgag gtgcgtgttt gtgcctgtcc tgggagagac cggcgcacag       60

aggaagagaa tctccgcaag aaaggggagc ctcaccacga gct                        103


<210> 13
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
ggtctagcta cagtgaaatc tcgatg                                            26


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ccaaatgatc cagatccaat tc                                                22


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
caaatgatcc agatccaatt c                                                 21


<210> 16
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ccaaatgatc cagatccaat tct                                               23


<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
tcttcttgtc cagctgta                                                     18


<210> 18
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ttttcccaac accacctgct ccaacc                                            26


<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
tttcccaaca ccacctgctc caacc                                             25


<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
ttttcccaac accacctgct ccaac                                             25


<210> 21
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ggagggggct gggccgggga cccgggaggg gtcg                                   34


<210> 22
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
ggagggggct gggccggkga cccgggaggg gtcg                                   34


<210> 23
<211> 5
<212> PRT
<213> Homo sapiens

<400> 23
Asp Ser Thr Pro Pro 
1               5   


<210> 24
<211> 6
<212> PRT
<213> Homo sapiens

<400> 24
Ala Pro Pro Gln His Leu 
1               5       


<210> 25
<211> 6
<212> PRT
<213> Homo sapiens

<400> 25
Arg Pro Ile Leu Thr Ile 
1               5       



