                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Xu, Xiaowei
       Wang, Huaishan
       Chen, Hui
       Ou, Lingling
 
<120>  METHODS TO DETERMINE TREATMENT EFFICACY WITH GAMMA-DELTA T CELLS

<130>  046483-7327WO1(02851)

<150>  63/174,879
<151>  2021-04-14

<150>  63/285,361
<151>  2021-12-02

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-human-CD19-BBZ CAR

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgc                                                   1458


<210>  2
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-human-CD19 scFv

<400>  2
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  3
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 Leader

<400>  3
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  4
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge and transmembrane domain

<400>  4
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  5
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  5
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  6
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta intracellular domain

<400>  6
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of 1

<400>  7

Gly Ser Gly Gly Ser 
1               5   


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeat n times, where n represents an integer of 1

<400>  8

Gly Gly Gly Ser 
1               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of 1

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Gly Gly Ser Gly 
1               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  11

Gly Gly Ser Gly Gly 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  12

Gly Ser Gly Ser Gly 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Gly Ser Gly Gly Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linekr

<400>  14

Gly Gly Gly Ser Gly 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  15

Gly Ser Ser Ser Gly 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  16

Gly Gly Gly Gly Ser 
1               5   


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


