                         SEQUENCE LISTING

<110>  The Administrators of the Tulane Educational Fund
 
<120>  METHOD AND COMPOSITIONS FOR PREVENTING TUMOR DEVELOPMENT AND 
       METASTASIS

<130>  TU-TM-680WO

<150>  63174527
<151>  2021-04-13

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  1
ccggcatgga actatcatta ccattctcga gaatggtaat gatagttcca tgtttttt         58


<210>  2
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  2
gmgmumgmgm gcacatgctc cmumumcmum                                        30


<210>  3
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Pro Gln Leu Gln Glu Thr Arg Met Asn Arg Ser Ile Pro Val 
1               5                   10                  15      


Glu Val Asp Glu Ser Glu Pro Tyr Pro Ser Gln Leu Leu Lys Pro Ile 
            20                  25                  30          


Pro Glu Tyr Ser Pro Glu Glu Glu Ser Glu Pro Pro Ala Pro Asn Ile 
        35                  40                  45              


Arg Asn Met Ala Pro Asn Ser Leu Ser Ala Pro Thr Met Leu His Asn 
    50                  55                  60                  


Ser Ser Gly Asp Phe Ser Gln Ala His Ser Thr Leu Lys Leu Ala Asn 
65                  70                  75                  80  


His Gln Arg Pro Val Ser Arg Gln Val Thr Cys Leu Arg Thr Gln Val 
                85                  90                  95      


Leu Glu Asp Ser Glu Asp Ser Phe Cys Arg Arg His Pro Gly Leu Gly 
            100                 105                 110         


Lys Ala Phe Pro Ser Gly Cys Ser Ala Val Ser Glu Pro Ala Ser Glu 
        115                 120                 125             


Ser Val Val Gly Ala Leu Pro Ala Glu His Gln Phe Ser Phe Met Glu 
    130                 135                 140                 


Lys Arg Asn Gln Trp Leu Val Ser Gln Leu Ser Ala Ala Ser Pro Asp 
145                 150                 155                 160 


Thr Gly His Asp Ser Asp Lys Ser Asp Gln Ser Leu Pro Asn Ala Ser 
                165                 170                 175     


Ala Asp Ser Leu Gly Gly Ser Gln Glu Met Val Gln Arg Pro Gln Pro 
            180                 185                 190         


His Arg Asn Arg Ala Gly Leu Asp Leu Pro Thr Ile Asp Thr Gly Tyr 
        195                 200                 205             


Asp Ser Gln Pro Gln Asp Val Leu Gly Ile Arg Gln Leu Glu Arg Pro 
    210                 215                 220                 


Leu Pro Leu Thr Ser Val Cys Tyr Pro Gln Asp Leu Pro Arg Pro Leu 
225                 230                 235                 240 


Arg Ser Arg Glu Phe Pro Gln Phe Glu Pro Gln Arg Tyr Pro Ala Cys 
                245                 250                 255     


Ala Gln Met Leu Pro Pro Asn Leu Ser Pro His Ala Pro Trp Asn Tyr 
            260                 265                 270         


His Tyr His Cys Pro Gly Ser Pro Asp His Gln Val Pro Tyr Gly His 
        275                 280                 285             


Asp Tyr Pro Arg Ala Ala Tyr Gln Gln Val Ile Gln Pro Ala Leu Pro 
    290                 295                 300                 


Gly Gln Pro Leu Pro Gly Ala Ser Val Arg Gly Leu His Pro Val Gln 
305                 310                 315                 320 


Lys Val Ile Leu Asn Tyr Pro Ser Pro Trp Asp His Glu Glu Arg Pro 
                325                 330                 335     


Ala Gln Arg Asp Cys Ser Phe Pro Gly Leu Pro Arg His Gln Asp Gln 
            340                 345                 350         


Pro His His Gln Pro Pro Asn Arg Ala Gly Ala Pro Gly Glu Ser Leu 
        355                 360                 365             


Glu Cys Pro Ala Glu Leu Arg Pro Gln Val Pro Gln Pro Pro Ser Pro 
    370                 375                 380                 


Ala Ala Val Pro Arg Pro Pro Ser Asn Pro Pro Ala Arg Gly Thr Leu 
385                 390                 395                 400 


Lys Thr Ser Asn Leu Pro Glu Glu Leu Arg Lys Val Phe Ile Thr Tyr 
                405                 410                 415     


Ser Met Asp Thr Ala Met Glu Val Val Lys Phe Val Asn Phe Leu Leu 
            420                 425                 430         


Val Asn Gly Phe Gln Thr Ala Ile Asp Ile Phe Glu Asp Arg Ile Arg 
        435                 440                 445             


Gly Ile Asp Ile Ile Lys Trp Met Glu Arg Tyr Leu Arg Asp Lys Thr 
    450                 455                 460                 


Val Met Ile Ile Val Ala Ile Ser Pro Lys Tyr Lys Gln Asp Val Glu 
465                 470                 475                 480 


Gly Ala Glu Ser Gln Leu Asp Glu Asp Glu His Gly Leu His Thr Lys 
                485                 490                 495     


Tyr Ile His Arg Met Met Gln Ile Glu Phe Ile Lys Gln Gly Ser Met 
            500                 505                 510         


Asn Phe Arg Phe Ile Pro Val Leu Phe Pro Asn Ala Lys Lys Glu His 
        515                 520                 525             


Val Pro Thr Trp Leu Gln Asn Thr His Val Tyr Ser Trp Pro Lys Asn 
    530                 535                 540                 


Lys Lys Asn Ile Leu Leu Arg Leu Leu Arg Glu Glu Glu Tyr Val Ala 
545                 550                 555                 560 


Pro Pro Arg Gly Pro Leu Pro Thr Leu Gln Val Val Pro Leu 
                565                 570                 


<210>  4
<211>  5944
<212>  DNA
<213>  Homo sapiens

<400>  4
gttcttctac ttacctgggc ccggagaagg tggagggaga cgagaagccg ccgagagccg       60

actaccctcc gggcccagtc tgtctgtccg tggtggatct aagcctcatc tgtatcctct      120

tgtgatggcg tgaaggaaag ccatggcaga tttccagcct ggtgatgctg tacagaacac      180

aggtggcctg cttccatgcc tcctcagctt caagaaacta gaatgaaccg aagcattcct      240

gtggaggttg atgaatcaga accataccca agtcagttgc tgaaaccaat cccagaatat      300

tccccggaag aggaatcaga accacctgct ccaaatataa ggaacatggc acccaacagc      360

ttgtctgcac ccacaatgct tcacaattcc tccggagact tttctcaagc tcactcaacc      420

ctgaaacttg caaatcacca gcggcctgta tcccggcagg tcacctgcct gcgcactcaa      480

gttctggagg acagtgaaga cagtttctgc aggagacacc caggcctggg caaagctttc      540

ccttctgggt gctctgcagt cagcgagcct gcgtctgagt ctgtggttgg agccctccct      600

gcagagcatc agttttcatt tatggaaaaa cgtaatcaat ggctggtatc tcagctttca      660

gcggcttctc ctgacactgg ccatgactca gacaaatcag accaaagttt acctaatgcc      720

tcagcagact ccttgggcgg tagccaggag atggtgcaac ggccccagcc tcacaggaac      780

cgagcaggcc tggatctgcc aaccatagac acgggatatg attcccagcc ccaggatgtc      840

ctgggcatca ggcagctgga aaggcccctg cccctcacct ccgtgtgtta cccccaggac      900

ctccccagac ctctcaggtc cagggagttc cctcagtttg aacctcagag gtatccagca      960

tgtgcacaga tgctgcctcc caatctttcc ccacatgctc catggaacta tcattaccat     1020

tgtcctggaa gtcccgatca ccaggtgcca tatggccatg actaccctcg agcagcctac     1080

cagcaagtga tccagccggc tctgcctggg cagcccctgc ctggagccag tgtgagaggc     1140

ctgcaccctg tgcagaaggt tatcctgaat tatcccagcc cctgggacca cgaagagagg     1200

cccgcacaga gagactgctc ctttccgggg cttccaaggc accaggacca gccacatcac     1260

cagccaccta atagagctgg tgctcctggg gagtccttgg agtgccctgc agagctgaga     1320

ccacaggttc cccagcctcc gtccccagct gctgtgccta gaccccctag caaccctcca     1380

gccagaggaa ctctaaaaac aagcaatttg ccagaagaat tgcggaaagt ctttatcact     1440

tattcgatgg acacagctat ggaggtggtg aaattcgtga actttttgtt ggtaaatggc     1500

ttccaaactg caattgacat atttgaggat agaatccgag gcattgatat cattaaatgg     1560

atggagcgct accttaggga taagaccgtg atgataatcg tagcaatcag ccccaaatac     1620

aaacaggacg tggaaggcgc tgagtcgcag ctggacgagg atgagcatgg cttacatact     1680

aagtacattc atcgaatgat gcagattgag ttcataaaac aaggaagcat gaatttcaga     1740

ttcatccctg tgctcttccc aaatgctaag aaggagcatg tgcccacctg gcttcagaac     1800

actcatgtct acagctggcc caagaataaa aaaaacatcc tgctgcggct gctgagagag     1860

gaagagtatg tggctcctcc acgggggcct ctgcccaccc ttcaggtggt tcccttgtga     1920

caccgttcat ccccagatca ctgaggccag gccatgtttg gggccttgtt ctgacagcat     1980

tctggctgag gctggtcggt agcactcctg gctggttttt ttctgttcct ccccgagagg     2040

ccctctggcc cccaggaaac ctgttgtgca gagctcttcc ccggagacct ccacacaccc     2100

tggctttgaa gtggagtctg tgactgctct gcattctctg cttttaaaaa aaccattgca     2160

ggtgccagtg tcccatatgt tcctcctgac agtttgatgt gtccattctg ggcctctcag     2220

tgcttagcaa gtagataatg taagggatgt ggcagcaaat ggaaatgact acaaacactc     2280

tcctatcaat cacttcaggc tacttttatg agttagccag atgcttgtgt atcctcagac     2340

caaactgatt catgtacaaa taataaaatg tttactcttt tgtaagatta tgttttactt     2400

atctcaaagg agatacatat aatttataat gatatgggca gttgcttcca gggacatcaa     2460

caaagctgct tagatataat attagataaa tataacagac cactctgtat taatggatta     2520

aagccagcta gttaaacaac cctttttaac cataatcatg gaagctttat tcttgcaata     2580

aagattttta ggctgggcgc agtgactcac acctgtaatc ccagcacttt gggaagctaa     2640

ggcaggcaga tcatttgagg tcaggagttt gagaccagcc tggccaacat ggtgaaaccc     2700

catctctgct aaaattacaa aaaagttagc cgggcatggt ggtgtgcacc tgtaatccca     2760

gctactcggg aggctgaggc aggagaatca cttgaacccg ggaggcagag gttgcagtga     2820

gccgagatca tgtcactgca ctctagcttg ggagacagag cgagactccg tctcaaaaaa     2880

caaacaaaca aataaaaaca cccattttta acaaaacaac tttatatagc atacagccat     2940

gattctaaat agtatgatta tggttctcag gatctgacta cataggtaaa aatatttgca     3000

tatgtgtatg aagtgttggg ggatgtaggc tagaattgta gtctgtgttc taattttggt     3060

tctaccacca attagctgta tgacctttag caagtccttt aacttttctt agattccagg     3120

gactcattta taaaatgaca tggacaaaag catctctaat cactctaaaa gatttgaagt     3180

ctaggaccta aattctaaat actcttttga ggagtgactg agttttcatt ttcataatta     3240

tgtctctcag aggacaaatt tacattttct taacagagac attttcttct tctttttttt     3300

tgtttgagac agagtctcgc tctgtcgtcc aggctggagt gcagtgctgc aatcttggct     3360

cactgcaacc tgcgcctcct gggttcaagt gattcttctg cctcaacctc ccaagtagct     3420

agacctatag gcgcctgcca ccatgcccag ctaatttttg tatttttagt agagacaggg     3480

tttcatattg gccagactgg tctcgaactc ctgaccttgt gatccgccca cctcggcctc     3540

ccaaagtgct gggattacag gtgtgagcca ccacacccag ccaacatttt cctcttttaa     3600

aaaatatctt ctcacgcctg taatcccagc actttgggag gctgaggcag gcggatcatg     3660

aggtcaggag atcaagacca tcctggctaa cacggtgaaa ctccatctct actaaaaata     3720

caaaaaaaat agccgggcgt ggtggcaggc gcctgtagtc ccagctactg gggaggctga     3780

ggcaggaaaa tggtgtcaac ccgggaggcg gagcttgcag tgagccgaga ttgcgccact     3840

gcactccagc ctgggcaata gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa     3900

cttcaacaat accctcaggt tgataatttt ggatatctat ctgtatctat atatcttgtt     3960

tacctggtct ccagaaaaag aacacataca catatccata tataaaatat gtatacatgt     4020

atcaaatcta cgtaaactat aaaggtggga tggctttaat tatggcccaa gctactaaga     4080

caatgaagac tttttggggc tgcaagctac tgcttccctt ctttatctac tagcctctta     4140

aacaaggctc acttgtgcta caagacagtc caccgttttg tttttttttt cttttttttg     4200

agacagggtc tcactctttc ccaggctgca gtacagtgac acagtctcag ctcactgcag     4260

ctttgacctt gccgggctca ggtgaccctt acacttcagc ctcccaagta gcagggacta     4320

taggtgtgca ccaacatgct tggttaattt ttgtattttt tgtagagaca gggttttgcc     4380

atgttgtcca ggctagtctc gaattcctgg gctcaagtga ttcacctgcc ttggcctccc     4440

aaagtgctag gattacagat gggagccacc acgcccagcc cagtccagct cttatatgta     4500

gcacagggaa aggacaaata cttgtcaact ataaataaga aacattgcta atgcattgca     4560

aagaacacta gtttcattta ctttataact tagatgtcta ctgggtgaga cgaatgtctt     4620

tgttctttaa aaaataggaa aagagaagaa aaactagcat aacataagta ctcatttgta     4680

agactttctg acatgtaaca ttagttccgt agttttgaga cctggtagaa ctgactttca     4740

tatttggata acctggaaaa cacccaaaca caaacttcaa gtcttctttc tcttttttca     4800

ttatcttttt tagtctgagg tgacaccatc attaaggatt cgacacccgt ttgtaaataa     4860

aatgacatca gcaattactc tgaaatgttt ctagtttgca aagacttagc aatgtgatgt     4920

tattaaccct tcctcccttc agagacctgt cctaagctct gaaccactca ttccttccac     4980

tcttcttacc ccaggtggtt gatgagcagt ggtccctggt gttccacaaa gagtcattaa     5040

agtgttacag ctggtagcac tggtagcaaa aaaacaaacc aaaaagtaca cacagacaca     5100

cacacacaca cgcacacata cacacacaca cgcacttggc caagtgacaa aagcttggcc     5160

cctgaaattt ctatgagatc cgatgaccac caacatcaaa gcattttttt tttttttttt     5220

ttgagacgta gtctcgctct gtcacccagg ctagagtgca gtggtgcaat cacagctcac     5280

tgcaacctcc acctcccggg ttcaagcgat tctcctgcct cagcctctcg agtagctgtg     5340

actacaggca cctgccacca tgcccggcta attttttgta tttttagtag agacggggtt     5400

tcaccgtgtt agccaggatg gtcttgatct cctgacctcg tgatccatcc gcctcggcct     5460

cccaaattgc tgggattaca ggcatgagcc accacgcccg gcccatcaaa ggaattgtaa     5520

caactatttg agagcactga caataagatt aacactcggt tgatttagat gttatgctgg     5580

tcctcaggca ttcatcttta gatatttttg gggtggaagt ggggtagggc tgacttagta     5640

aaaataacct cttagcccaa aggctttatt cagacttaca ccgatttgag gggtgggttt     5700

gtggaatgca aggttaggtt cttacctaat atttgatgac taatttagaa ttttaaatgt     5760

aattttaaat tttagtgact ggtttcaaat ctattttaac ttctagattg ttcaaagagg     5820

tctcagtaca tggctacaat caaagtatta gactagctat ttctcagctc agtgctcaga     5880

aaaattatta ctgttgatac ctttttcttt gtttcctgtt aaataaatca cctctttaaa     5940

gaca                                                                  5944


<210>  5
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Arg Ser Ile Pro Val Glu Val Asp Glu Ser Glu Pro Tyr Pro 
1               5                   10                  15      


Ser Gln Leu Leu Lys Pro Ile Pro Glu Tyr Ser Pro Glu Glu Glu Ser 
            20                  25                  30          


Glu Pro Pro Ala Pro Asn Ile Arg Asn Met Ala Pro Asn Ser Leu Ser 
        35                  40                  45              


Ala Pro Thr Met Leu His Asn Ser Ser Gly Asp Phe Ser Gln Ala His 
    50                  55                  60                  


Ser Thr Leu Lys Leu Ala Asn His Gln Arg Pro Val Ser Arg Gln Val 
65                  70                  75                  80  


Thr Cys Leu Arg Thr Gln Val Leu Glu Asp Ser Glu Asp Ser Phe Cys 
                85                  90                  95      


Arg Arg His Pro Gly Leu Gly Lys Ala Phe Pro Ser Gly Cys Ser Ala 
            100                 105                 110         


Val Ser Glu Pro Ala Ser Glu Ser Val Val Gly Ala Leu Pro Ala Glu 
        115                 120                 125             


His Gln Phe Ser Phe Met Glu Lys Arg Asn Gln Trp Leu Val Ser Gln 
    130                 135                 140                 


Leu Ser Ala Ala Ser Pro Asp Thr Gly His Asp Ser Asp Lys Ser Asp 
145                 150                 155                 160 


Gln Ser Leu Pro Asn Ala Ser Ala Asp Ser Leu Gly Gly Ser Gln Glu 
                165                 170                 175     


Met Val Gln Arg Pro Gln Pro His Arg Asn Arg Ala Gly Leu Asp Leu 
            180                 185                 190         


Pro Thr Ile Asp Thr Gly Tyr Asp Ser Gln Pro Gln Asp Val Leu Gly 
        195                 200                 205             


Ile Arg Gln Leu Glu Arg Pro Leu Pro Leu Thr Ser Val Cys Tyr Pro 
    210                 215                 220                 


Gln Asp Leu Pro Arg Pro Leu Arg Ser Arg Glu Phe Pro Gln Phe Glu 
225                 230                 235                 240 


Pro Gln Arg Tyr Pro Ala Cys Ala Gln Met Leu Pro Pro Asn Leu Ser 
                245                 250                 255     


Pro His Ala Pro Trp Asn Tyr His Tyr His Cys Pro Gly Ser Pro Asp 
            260                 265                 270         


His Gln Val Pro Tyr Gly His Asp Tyr Pro Arg Ala Ala Tyr Gln Gln 
        275                 280                 285             


Val Ile Gln Pro Ala Leu Pro Gly Gln Pro Leu Pro Gly Ala Ser Val 
    290                 295                 300                 


Arg Gly Leu His Pro Val Gln Lys Val Ile Leu Asn Tyr Pro Ser Pro 
305                 310                 315                 320 


Trp Asp His Glu Glu Arg Pro Ala Gln Arg Asp Cys Ser Phe Pro Gly 
                325                 330                 335     


Leu Pro Arg His Gln Asp Gln Pro His His Gln Pro Pro Asn Arg Ala 
            340                 345                 350         


Gly Ala Pro Gly Glu Ser Leu Glu Cys Pro Ala Glu Leu Arg Pro Gln 
        355                 360                 365             


Val Pro Gln Pro Pro Ser Pro Ala Ala Val Pro Arg Pro Pro Ser Asn 
    370                 375                 380                 


Pro Pro Ala Arg Gly Thr Leu Lys Thr Ser Asn Leu Pro Glu Glu Leu 
385                 390                 395                 400 


Arg Lys Val Phe Ile Thr Tyr Ser Met Asp Thr Ala Met Glu Val Val 
                405                 410                 415     


Lys Phe Val Asn Phe Leu Leu Val Asn Gly Phe Gln Thr Ala Ile Asp 
            420                 425                 430         


Ile Phe Glu Asp Arg Ile Arg Gly Ile Asp Ile Ile Lys Trp Met Glu 
        435                 440                 445             


Arg Tyr Leu Arg Asp Lys Thr Val Met Ile Ile Val Ala Ile Ser Pro 
    450                 455                 460                 


Lys Tyr Lys Gln Asp Val Glu Gly Ala Glu Ser Gln Leu Asp Glu Asp 
465                 470                 475                 480 


Glu His Gly Leu His Thr Lys Tyr Ile His Arg Met Met Gln Ile Glu 
                485                 490                 495     


Phe Ile Lys Gln Gly Ser Met Asn Phe Arg Phe Ile Pro Val Leu Phe 
            500                 505                 510         


Pro Asn Ala Lys Lys Glu His Val Pro Thr Trp Leu Gln Asn Thr His 
        515                 520                 525             


Val Tyr Ser Trp Pro Lys Asn Lys Lys Asn Ile Leu Leu Arg Leu Leu 
    530                 535                 540                 


Arg Glu Glu Glu Tyr Val Ala Pro Pro Arg Gly Pro Leu Pro Thr Leu 
545                 550                 555                 560 


Gln Val Val Pro Leu 
                565 


<210>  6
<211>  940
<212>  DNA
<213>  Homo sapiens

<400>  6
gttcttctac ttacctgggc ccggagaagg tggagggaga cgagaagccg ccgagagccg       60

actaccctcc gggcccagtc tgtctgtccg tggtggatct aagaaactag aatgaaccga      120

agcattcctg tggaggttga tgaatcagaa ccatacccaa gtcagttgct gaaaccaatc      180

ccagaatatt ccccggaaga ggaatcagaa ccacctgctc caaatataag gaacatggca      240

cccaacagct tgtctgcacc cacaatgctt cacaattcct ccggagactt ttctcaagct      300

cactcaaccc tgaaacttgc aaatcaccag cggcctgtat cccggcaggt cacctgcctg      360

cgcactcaag ttctggagga cagtgaagac agtttctgca ggagacaccc aggcctgggc      420

aaagctttcc cttctgggtg ctctgcagtc agcgagcctg cgtctgagtc tgtggttgga      480

gccctccctg cagagcatca gttttcattt atggaaaaac gtaatcaatg gctggtatct      540

cagctttcag cggcttctcc tgacactggc catgactcag acaaatcaga ccaaagttta      600

cctaatgcct cagcagactc cttgggcggt agccaggaga tggtgcaacg gccccagcct      660

cacaggaacc gagcaggcct ggatctgcca accatagaca cgggatatga ttcccagccc      720

caggatgtcc tgggcatcag gcagctggaa aggcccctgc ccctcacctc cgtgtgttac      780

ccccaggacc tccccagacc tctcaggtcc agggagttcc ctcagtttga acctcagagg      840

tatccagcat gtgcacagat gctgcctccc aatctttccc cacatgctcc atggaactat      900

cattaccatt gtcctggaag tcccgatcac caggtgccat                            940


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Pro Gln Leu Gln Glu Thr Arg 
1               5                   


<210>  8
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  8
atgcctcctc agcttcaaga aactaga                                           27


<210>  9
<211>  6241
<212>  DNA
<213>  Homo sapiens

<400>  9
aatgctgatg ttttaagcag ttagaggagg tggaagaagc tcgactccct cttcttcccc       60

attatctgcc cacaatcccc tcctttggag ctgctaatga ttactaattc ttaacattcg      120

agttcaatct cctcccggag acaccctccc aggcgagggc actgcgacta cactgaggtt      180

ctgcccactc ctgggcagct tcttagctgg gtggcgaaaa caaaaatgcc gcctaattgg      240

tcactggccc tttctcatga atgaaggagg tttctgtttt aagaaataaa gtgactcctc      300

agccgttgat tcactgccca cagggagatt ttgagcagag gcttcctagg ctccgtagaa      360

atttgcatac agcttccact tcctgcttca gagcctgttc ttctacttac ctgggcccgg      420

agaaggtgga gggagacgag aagccgccga gagccgacta ccctccgggc ccagtctgtc      480

tgtccgtggt ggatctaaga aactagaatg aaccgaagca ttcctgtgga ggttgatgaa      540

tcagaaccat acccaagtca gttgctgaaa ccaatcccag aatattcccc ggaagaggaa      600

tcagaaccac ctgctccaaa tataaggaac atggcaccca acagcttgtc tgcacccaca      660

atgcttcaca attcctccgg agacttttct caagctcact caaccctgaa acttgcaaat      720

caccagcggc ctgtatcccg gcaggtcacc tgcctgcgca ctcaagttct ggaggacagt      780

gaagacagtt tctgcaggag acacccaggc ctgggcaaag ctttcccttc tgggtgctct      840

gcagtcagcg agcctgcgtc tgagtctgtg gttggagccc tccctgcaga gcatcagttt      900

tcatttatgg aaaaacgtaa tcaatggctg gtatctcagc tttcagcggc ttctcctgac      960

actggccatg actcagacaa atcagaccaa agtttaccta atgcctcagc agactccttg     1020

ggcggtagcc aggagatggt gcaacggccc cagcctcaca ggaaccgagc aggcctggat     1080

ctgccaacca tagacacggg atatgattcc cagccccagg atgtcctggg catcaggcag     1140

ctggaaaggc ccctgcccct cacctccgtg tgttaccccc aggacctccc cagacctctc     1200

aggtccaggg agttccctca gtttgaacct cagaggtatc cagcatgtgc acagatgctg     1260

cctcccaatc tttccccaca tgctccatgg aactatcatt accattgtcc tggaagtccc     1320

gatcaccagg tgccatatgg ccatgactac cctcgagcag cctaccagca agtgatccag     1380

ccggctctgc ctgggcagcc cctgcctgga gccagtgtga gaggcctgca ccctgtgcag     1440

aaggttatcc tgaattatcc cagcccctgg gaccacgaag agaggcccgc acagagagac     1500

tgctcctttc cggggcttcc aaggcaccag gaccagccac atcaccagcc acctaataga     1560

gctggtgctc ctggggagtc cttggagtgc cctgcagagc tgagaccaca ggttccccag     1620

cctccgtccc cagctgctgt gcctagaccc cctagcaacc ctccagccag aggaactcta     1680

aaaacaagca atttgccaga agaattgcgg aaagtcttta tcacttattc gatggacaca     1740

gctatggagg tggtgaaatt cgtgaacttt ttgttggtaa atggcttcca aactgcaatt     1800

gacatatttg aggatagaat ccgaggcatt gatatcatta aatggatgga gcgctacctt     1860

agggataccg tgatgataat cgtagcaatc agccccaaat acaaacagga cgtggaaggc     1920

gctgagtcgc agctggacga ggatgagcat ggcttacata ctaagtacat tcatcgaatg     1980

atgcagattg agttcataaa acaaggaagc atgaatttca gattcatccc tgtgctcttc     2040

ccaaatgcta agaaggagca tgtgcccacc tggcttcaga acactcatgt ctacagctgg     2100

cccaagaata aaaaaaacat cctgctgcgg ctgctgagag aggaagagta tgtggctcct     2160

ccacgggggc ctctgcccac ccttcaggtg gttcccttgt gacaccgttc atccccagat     2220

cactgaggcc aggccatgtt tggggccttg ttctgacagc attctggctg aggctggtcg     2280

gtagcactcc tggctggttt ttttctgttc ctccccgaga ggccctctgg cccccaggaa     2340

acctgttgtg cagagctctt ccccggagac ctccacacac cctggctttg aagtggagtc     2400

tgtgactgct ctgcattctc tgcttttaaa aaaaccattg caggtgccag tgtcccatat     2460

gttcctcctg acagtttgat gtgtccattc tgggcctctc agtgcttagc aagtagataa     2520

tgtaagggat gtggcagcaa atggaaatga ctacaaacac tctcctatca atcacttcag     2580

gctactttta tgagttagcc agatgcttgt gtatcctcag accaaactga ttcatgtaca     2640

aataataaaa tgtttactct tttgtaagat tatgttttac ttatctcaaa ggagatacat     2700

ataatttata atgatatggg cagttgcttc cagggacatc aacaaagctg cttagatata     2760

atattagata aatataacag accactctgt attaatggat taaagccagc tagttaaaca     2820

acccttttta accataatca tggaagcttt attcttgcaa taaagatttt taggctgggc     2880

gcagtgactc acacctgtaa tcccagcact ttgggaagct aaggcaggca gatcatttga     2940

ggtcaggagt ttgagaccag cctggccaac atggtgaaac cccatctctg ctaaaattac     3000

aaaaaagtta gccgggcatg gtggtgtgca cctgtaatcc cagctactcg ggaggctgag     3060

gcaggagaat cacttgaacc cgggaggcag aggttgcagt gagccgagat catgtcactg     3120

cactctagct tgggagacag agcgagactc cgtctcaaaa aacaaacaaa caaataaaaa     3180

cacccatttt taacaaaaca actttatata gcatacagcc atgattctaa atagtatgat     3240

tatggttctc aggatctgac tacataggta aaaatatttg catatgtgta tgaagtgttg     3300

ggggatgtag gctagaattg tagtctgtgt tctaattttg gttctaccac caattagctg     3360

tatgaccttt agcaagtcct ttaacttttc ttagattcca gggactcatt tataaaatga     3420

catggacaaa agcatctcta atcactctaa aagatttgaa gtctaggacc taaattctaa     3480

atactctttt gaggagtgac tgagttttca ttttcataat tatgtctctc agaggacaaa     3540

tttacatttt cttaacagag acattttctt cttctttttt tttgtttgag acagagtctc     3600

gctctgtcgt ccaggctgga gtgcagtgct gcaatcttgg ctcactgcaa cctgcgcctc     3660

ctgggttcaa gtgattcttc tgcctcaacc tcccaagtag ctagacctat aggcgcctgc     3720

caccatgccc agctaatttt tgtattttta gtagagacag ggtttcatat tggccagact     3780

ggtctcgaac tcctgacctt gtgatccgcc cacctcggcc tcccaaagtg ctgggattac     3840

aggtgtgagc caccacaccc agccaacatt ttcctctttt aaaaaatatc ttctcacgcc     3900

tgtaatccca gcactttggg aggctgaggc aggcggatca tgaggtcagg agatcaagac     3960

catcctggct aacacggtga aactccatct ctactaaaaa tacaaaaaaa atagccgggc     4020

gtggtggcag gcgcctgtag tcccagctac tggggaggct gaggcaggaa aatggtgtca     4080

acccgggagg cggagcttgc agtgagccga gattgcgcca ctgcactcca gcctgggcaa     4140

tagagtgaga ctccgtctca aaaaaaaaaa aaaaaaaaaa aacttcaaca ataccctcag     4200

gttgataatt ttggatatct atctgtatct atatatcttg tttacctggt ctccagaaaa     4260

agaacacata cacatatcca tatataaaat atgtatacat gtatcaaatc tacgtaaact     4320

ataaaggtgg gatggcttta attatggccc aagctactaa gacaatgaag actttttggg     4380

gctgcaagct actgcttccc ttctttatct actagcctct taaacaaggc tcacttgtgc     4440

tacaagacag tccaccgttt tgtttttttt ttcttttttt tgagacaggg tctcactctt     4500

tcccaggctg cagtacagtg acacagtctc agctcactgc agctttgacc ttgccgggct     4560

caggtgaccc ttacacttca gcctcccaag tagcagggac tataggtgtg caccaacatg     4620

cttggttaat ttttgtattt tttgtagaga cagggttttg ccatgttgtc caggctagtc     4680

tcgaattcct gggctcaagt gattcacctg ccttggcctc ccaaagtgct aggattacag     4740

atgggagcca ccacgcccag cccagtccag ctcttatatg tagcacaggg aaaggacaaa     4800

tacttgtcaa ctataaataa gaaacattgc taatgcattg caaagaacac tagtttcatt     4860

tactttataa cttagatgtc tactgggtga gacgaatgtc tttgttcttt aaaaaatagg     4920

aaaagagaag aaaaactagc ataacataag tactcatttg taagactttc tgacatgtaa     4980

cattagttcc gtagttttga gacctggtag aactgacttt catatttgga taacctggaa     5040

aacacccaaa cacaaacttc aagtcttctt tctctttttt cattatcttt tttagtctga     5100

ggtgacacca tcattaagga ttcgacaccc gtttgtaaat aaaatgacat cagcaattac     5160

tctgaaatgt ttctagtttg caaagactta gcaatgtgat gttattaacc cttcctccct     5220

tcagagacct gtcctaagct ctgaaccact cattccttcc actcttctta ccccaggtgg     5280

ttgatgagca gtggtccctg gtgttccaca aagagtcatt aaagtgttac agctggtagc     5340

actggtagca aaaaaacaaa ccaaaaagta cacacagaca cacacacaca cacgcacaca     5400

tacacacaca cacgcacttg gccaagtgac aaaagcttgg cccctgaaat ttctatgaga     5460

tccgatgacc accaacatca aagcattttt tttttttttt ttttgagacg tagtctcgct     5520

ctgtcaccca ggctagagtg cagtggtgca atcacagctc actgcaacct ccacctcccg     5580

ggttcaagcg attctcctgc ctcagcctct cgagtagctg tgactacagg cacctgccac     5640

catgcccggc taattttttg tatttttagt agagacgggg tttcaccgtg ttagccagga     5700

tggtcttgat ctcctgacct cgtgatccat ccgcctcggc ctcccaaatt gctgggatta     5760

caggcatgag ccaccacgcc cggcccatca aaggaattgt aacaactatt tgagagcact     5820

gacaataaga ttaacactcg gttgatttag atgttatgct ggtcctcagg cattcatctt     5880

tagatatttt tggggtggaa gtggggtagg gctgacttag taaaaataac ctcttagccc     5940

aaaggcttta ttcagactta caccgatttg aggggtgggt ttgtggaatg caaggttagg     6000

ttcttaccta atatttgatg actaatttag aattttaaat gtaattttaa attttagtga     6060

ctggtttcaa atctatttta acttctagat tgttcaaaga ggtctcagta catggctaca     6120

atcaaagtat tagactagct atttctcagc tcagtgctca gaaaaattat tactgttgat     6180

acctttttct ttgtttcctg ttaaataaat cacctcttta aagacagaaa aaaaaaaaaa     6240

a                                                                     6241


<210>  10
<211>  2474
<212>  DNA
<213>  Homo sapiens

<400>  10
ggagattttg agcagaggct tcctaggctc cgtagaaatt tgcatacagc ttccacttcc       60

tgcttcagag cctgttcttc tacttacctg ggcccggaga aggtggaggg agacgagaag      120

ccgccgagag ccgactaccc tccgggccca gtctgtctgt ccgtggtgga tctaagcctc      180

atctgtatcc tcttgtgatg gcgtgaagga aagccatggc agatttccag cctggtgatg      240

ctgtacagaa cacaggtggc ctgcttccat gcctcctcag cttcaagaaa ctagaatgaa      300

ccgaagcatt cctgtggagg ttgatgaatc agaaccatac ccaagtcagt tgctgaaacc      360

aatcccagaa tattccccgg aagaggaatc agaaccacct gctccaaata taaggaacat      420

ggcacccaac agcttgtctg cacccacaat gcttcacaat tcctccggag acttttctca      480

agctcactca accctgaaac ttgcaaatca ccagcggcct gtatcccggc aggtcacctg      540

cctgcgcact caagttctgg aggacagtga agacagtttc tgcaggagac acccaggcct      600

gggcaaagct ttcccttctg ggtgctctgc agtcagcgag cctgcgtctg agtctgtggt      660

tggagccctc cctgcagagc atcagttttc atttatggaa aaacgtaatc aatggctggt      720

atctcagctt tcagcggctt ctcctgacac tggccatgac tcagacaaat cagaccaaag      780

tttacctaat gcctcagcag actccttggg cggtagccag gagatggtgc aacggcccca      840

gcctcacagg aaccgagcag gcctggatct gccaaccata gacacgggat atgattccca      900

gccccaggat gtcctgggca tcaggcagct ggaaaggccc ctgcccctca cctccgtgtg      960

ttacccccag gacctcccca gacctctcag gtccagggag ttccctcagt ttgaacctca     1020

gaggtatcca gcatgtgcac agatgctgcc tcccaatctt tccccacatg ctccatggaa     1080

ctatcattac cattgtcctg gaagtcccga tcaccaggtg ccatatggcc atgactaccc     1140

tcgagcagcc taccagcaag tgatccagcc ggctctgcct gggcagcccc tgcctggagc     1200

cagtgtgaga ggcctgcacc ctgtgcagaa ggttatcctg aattatccca gcccctggga     1260

ccacgaagag aggcccgcac agagagactg ctcctttccg gggcttccaa ggcaccagga     1320

ccagccacat caccagccac ctaatagagc tggtgctcct ggggagtcct tggagtgccc     1380

tgcagagctg agaccacagg ttccccagcc tccgtcccca gctgctgtgc ctagaccccc     1440

tagcaaccct ccagccagag gaactctaaa aacaagcaat ttgccagaag aattgcggaa     1500

agtctttatc acttattcga tggacacagc tatggaggtg gtgaaattcg tgaacttttt     1560

gttggtaaat ggcttccaaa ctgcaattga catatttgag gatagaatcc gaggcattga     1620

tatcattaaa tggatggagc gctaccttag ggataagacc gtgatgataa tcgtagcaat     1680

cagccccaaa tacaaacagg acgtggaagg cgctgagtcg cagctggacg aggatgagca     1740

tggcttacat actaagtaca ttcatcgaat gatgcagatt gagttcataa aacaaggaag     1800

catgaatttc agattcatcc ctgtgctctt cccaaatgct aagaaggagc atgtgcccac     1860

ctggcttcag aacactcatg tctacagctg gcccaagaat aaaaaaaaca tcctgctgcg     1920

gctgctgaga gaggaagagt atgtggctcc tccacggggg cctctgccca cccttcaggt     1980

ggttcccttg tgacaccgtt catccccaga tcactgaggc caggccatgt ttggggcctt     2040

gttctgacag cattctggct gaggctggtc ggtagcactc ctggctggtt tttttctgtt     2100

cctccccgag aggccctctg gcccccagga aacctgttgt gcagagctct tccccggaga     2160

cctccacaca ccctggcttt gaagtggagt ctgtgactgc tctgcattct ctgcttttaa     2220

aaaaaccatt gcaggtgcca gtgtcccata tgttcctcct gacagtttga tgtgtccatt     2280

ctgggcctct cagtgcttag caagtagata atgtaaggga tgtggcagca aatggaaatg     2340

actacaaaca ctctcctatc aatcacttca ggctactttt atgagttagc cagatgcttg     2400

tgtatcctca gaccaaactg attcatgtac aaataataaa atgtttactc ttttgtaaaa     2460

aaaaaaaaaa aaaa                                                       2474


<210>  11
<211>  2819
<212>  DNA
<213>  Homo sapiens

<400>  11
tacaggcgtg agtcaccgcg ctcggcaatg ctgatgtttt aagcagttag aggaggtgga       60

agaagctcga ctccctcttc ttccccatta tctgcccaca atcccctcct ttggagctgc      120

taatgattac taattcttaa cattcgagtt caatctcctc ccggagacac cctcccaggc      180

gagggcactg cgactacact gaggttctgc ccactcctgg gcagcttctt agctgggtgg      240

cgaaaacaaa aatgccgcct aattggtcac tggccctttc tcatgaatga aggaggtttc      300

tgttttaaga aataaagtga ctcctcagcc gttgattcac tgcccacagg gagattttga      360

gcagaggctt cctaggctcc gtagaaattt gcatacagct tccacttcct gcttcagagc      420

ctgttcttct acttacctgg gcccggagaa ggtggaggga gacgagaagc cgccgagagc      480

cgactaccct ccgggcccag tctgtctgtc cgtggtggat ctaagatgcc tctgcagcct      540

catctgtatc ctcttgtgat ggcgtgaagg aaagccatgg cagatttcca gcctggtgat      600

gctgtacaga acacaggtgg cctgcttcca tgcctcctca gcttcaagaa actagaatga      660

accgaagcat tcctgtggag gttgatgaat cagaaccata cccaagtcag ttgctgaaac      720

caatcccaga atattccccg gaagaggaat cagaaccacc tgctccaaat ataaggaaca      780

tggcacccaa cagcttgtct gcacccacaa tgcttcacaa ttcctccgga gacttttctc      840

aagctcactc aaccctgaaa cttgcaaatc accagcggcc tgtatcccgg caggtcacct      900

gcctgcgcac tcaagttctg gaggacagtg aagacagttt ctgcaggaga cacccaggcc      960

tgggcaaagc tttcccttct gggtgctctg cagtcagcga gcctgcgtct gagtctgtgg     1020

ttggagccct ccctgcagag catcagtttt catttatgga aaaacgtaat caatggctgg     1080

tatctcagct ttcagcggct tctcctgaca ctggccatga ctcagacaaa tcagaccaaa     1140

gtttacctaa tgcctcagca gactccttgg gcggtagcca ggagatggtg caacggcccc     1200

agcctcacag gaaccgagca ggcctggatc tgccaaccat agacacggga tatgattccc     1260

agccccagga tgtcctgggc atcaggcagc tggaaaggcc cctgcccctc acctccgtgt     1320

gttaccccca ggacctcccc agacctctca ggtccaggga gttccctcag tttgaacctc     1380

agaggtatcc agcatgtgca cagatgctgc ctcccaatct ttccccacat gctccatgga     1440

actatcatta ccattgtcct ggaagtcccg atcaccaggt gccatatggc catgactacc     1500

ctcgagcagc ctaccagcaa gtgatccagc cggctctgcc tgggcagccc ctgcctggag     1560

ccagtgtgag aggcctgcac cctgtgcaga aggttatcct gaattatccc agcccctggg     1620

accacgaaga gaggcccgca cagagagact gctcctttcc ggggcttcca aggcaccagg     1680

accagccaca tcaccagcca cctaatagag ctggtgctcc tggggagtcc ttggagtgcc     1740

ctgcagagct gagaccacag gttccccagc ctccgtcccc agctgctgtg cctagacccc     1800

ctagcaaccc tccagccaga ggaactctaa aaacaagcaa tttgccagaa gaattgcgga     1860

aagtctttat cacttattcg atggacacag ctatggaggt ggtgaaattc gtgaactttt     1920

tgttggtaaa tggcttccaa actgcaattg acatatttga ggatagaatc cgaggcattg     1980

atatcattaa atggatggag cgctacctta gggataagac cgtgatgata atcgtagcaa     2040

tcagccccaa atacaaacag gacgtggaag gcgctgagtc gcagctggac gaggatgagc     2100

atggcttaca tactaagtac attcatcgaa tgatgcagat tgagttcata aaacaaggaa     2160

gcatgaattt cagattcatc cctgtgctct tcccaaatgc taagaaggag catgtgccca     2220

cctggcttca gaacactcat gtctacagct ggcccaagaa taaaaaaaac atcctgctgc     2280

ggctgctgag agaggaagag tatgtggctc ctccacgggg gcctctgccc acccttcagg     2340

tggttccctt gtgacaccgt tcatccccag atcactgagg ccaggccatg tttggggcct     2400

tgttctgaca gcattctggc tgaggctggt cggtagcact cctggctggt ttttttctgt     2460

tcctccccga gaggccctct ggcccccagg aaacctgttg tgcagagctc ttccccggag     2520

acctccacac accctggctt tgaagtggag tctgtgactg ctctgcattc tctgctttta     2580

aaaaaaccat tgcaggtgcc agtgtcccat atgttcctcc tgacagtttg atgtgtccat     2640

tctgggcctc tcagtgctta gcaagtagat aatgtaaggg atgtggcagc aaatggaaat     2700

gactacaaac actctcctat caatcacttc aggctacttt tatgagttag ccagatgctt     2760

gtgtatcctc agaccaaact gattcatgta caaataataa aatgtttact cttttgtaa      2819


<210>  12
<211>  6244
<212>  DNA
<213>  Homo sapiens

<400>  12
aatgctgatg ttttaagcag ttagaggagg tggaagaagc tcgactccct cttcttcccc       60

attatctgcc cacaatcccc tcctttggag ctgctaatga ttactaattc ttaacattcg      120

agttcaatct cctcccggag acaccctccc aggcgagggc actgcgacta cactgaggtt      180

ctgcccactc ctgggcagct tcttagctgg gtggcgaaaa caaaaatgcc gcctaattgg      240

tcactggccc tttctcatga atgaaggagg tttctgtttt aagaaataaa gtgactcctc      300

agccgttgat tcactgccca cagggagatt ttgagcagag gcttcctagg ctccgtagaa      360

atttgcatac agcttccact tcctgcttca gagcctgttc ttctacttac ctgggcccgg      420

agaaggtgga gggagacgag aagccgccga gagccgacta ccctccgggc ccagtctgtc      480

tgtccgtggt ggatctaaga aactagaatg aaccgaagca ttcctgtgga ggttgatgaa      540

tcagaaccat acccaagtca gttgctgaaa ccaatcccag aatattcccc ggaagaggaa      600

tcagaaccac ctgctccaaa tataaggaac atggcaccca acagcttgtc tgcacccaca      660

atgcttcaca attcctccgg agacttttct caagctcact caaccctgaa acttgcaaat      720

caccagcggc ctgtatcccg gcaggtcacc tgcctgcgca ctcaagttct ggaggacagt      780

gaagacagtt tctgcaggag acacccaggc ctgggcaaag ctttcccttc tgggtgctct      840

gcagtcagcg agcctgcgtc tgagtctgtg gttggagccc tccctgcaga gcatcagttt      900

tcatttatgg aaaaacgtaa tcaatggctg gtatctcagc tttcagcggc ttctcctgac      960

actggccatg actcagacaa atcagaccaa agtttaccta atgcctcagc agactccttg     1020

ggcggtagcc aggagatggt gcaacggccc cagcctcaca ggaaccgagc aggcctggat     1080

ctgccaacca tagacacggg atatgattcc cagccccagg atgtcctggg catcaggcag     1140

ctggaaaggc ccctgcccct cacctccgtg tgttaccccc aggacctccc cagacctctc     1200

aggtccaggg agttccctca gtttgaacct cagaggtatc cagcatgtgc acagatgctg     1260

cctcccaatc tttccccaca tgctccatgg aactatcatt accattgtcc tggaagtccc     1320

gatcaccagg tgccatatgg ccatgactac cctcgagcag cctaccagca agtgatccag     1380

ccggctctgc ctgggcagcc cctgcctgga gccagtgtga gaggcctgca ccctgtgcag     1440

aaggttatcc tgaattatcc cagcccctgg gaccacgaag agaggcccgc acagagagac     1500

tgctcctttc cggggcttcc aaggcaccag gaccagccac atcaccagcc acctaataga     1560

gctggtgctc ctggggagtc cttggagtgc cctgcagagc tgagaccaca ggttccccag     1620

cctccgtccc cagctgctgt gcctagaccc cctagcaacc ctccagccag aggaactcta     1680

aaaacaagca atttgccaga agaattgcgg aaagtcttta tcacttattc gatggacaca     1740

gctatggagg tggtgaaatt cgtgaacttt ttgttggtaa atggcttcca aactgcaatt     1800

gacatatttg aggatagaat ccgaggcatt gatatcatta aatggatgga gcgctacctt     1860

agggataaga ccgtgatgat aatcgtagca atcagcccca aatacaaaca ggacgtggaa     1920

ggcgctgagt cgcagctgga cgaggatgag catggcttac atactaagta cattcatcga     1980

atgatgcaga ttgagttcat aaaacaagga agcatgaatt tcagattcat ccctgtgctc     2040

ttcccaaatg ctaagaagga gcatgtgccc acctggcttc agaacactca tgtctacagc     2100

tggcccaaga ataaaaaaaa catcctgctg cggctgctga gagaggaaga gtatgtggct     2160

cctccacggg ggcctctgcc cacccttcag gtggttccct tgtgacaccg ttcatcccca     2220

gatcactgag gccaggccat gtttggggcc ttgttctgac agcattctgg ctgaggctgg     2280

tcggtagcac tcctggctgg tttttttctg ttcctccccg agaggccctc tggcccccag     2340

gaaacctgtt gtgcagagct cttccccgga gacctccaca caccctggct ttgaagtgga     2400

gtctgtgact gctctgcatt ctctgctttt aaaaaaacca ttgcaggtgc cagtgtccca     2460

tatgttcctc ctgacagttt gatgtgtcca ttctgggcct ctcagtgctt agcaagtaga     2520

taatgtaagg gatgtggcag caaatggaaa tgactacaaa cactctccta tcaatcactt     2580

caggctactt ttatgagtta gccagatgct tgtgtatcct cagaccaaac tgattcatgt     2640

acaaataata aaatgtttac tcttttgtaa gattatgttt tacttatctc aaaggagata     2700

catataattt ataatgatat gggcagttgc ttccagggac atcaacaaag ctgcttagat     2760

ataatattag ataaatataa cagaccactc tgtattaatg gattaaagcc agctagttaa     2820

acaacccttt ttaaccataa tcatggaagc tttattcttg caataaagat ttttaggctg     2880

ggcgcagtga ctcacacctg taatcccagc actttgggaa gctaaggcag gcagatcatt     2940

tgaggtcagg agtttgagac cagcctggcc aacatggtga aaccccatct ctgctaaaat     3000

tacaaaaaag ttagccgggc atggtggtgt gcacctgtaa tcccagctac tcgggaggct     3060

gaggcaggag aatcacttga acccgggagg cagaggttgc agtgagccga gatcatgtca     3120

ctgcactcta gcttgggaga cagagcgaga ctccgtctca aaaaacaaac aaacaaataa     3180

aaacacccat ttttaacaaa acaactttat atagcataca gccatgattc taaatagtat     3240

gattatggtt ctcaggatct gactacatag gtaaaaatat ttgcatatgt gtatgaagtg     3300

ttgggggatg taggctagaa ttgtagtctg tgttctaatt ttggttctac caccaattag     3360

ctgtatgacc tttagcaagt cctttaactt ttcttagatt ccagggactc atttataaaa     3420

tgacatggac aaaagcatct ctaatcactc taaaagattt gaagtctagg acctaaattc     3480

taaatactct tttgaggagt gactgagttt tcattttcat aattatgtct ctcagaggac     3540

aaatttacat tttcttaaca gagacatttt cttcttcttt ttttttgttt gagacagagt     3600

ctcgctctgt cgtccaggct ggagtgcagt gctgcaatct tggctcactg caacctgcgc     3660

ctcctgggtt caagtgattc ttctgcctca acctcccaag tagctagacc tataggcgcc     3720

tgccaccatg cccagctaat ttttgtattt ttagtagaga cagggtttca tattggccag     3780

actggtctcg aactcctgac cttgtgatcc gcccacctcg gcctcccaaa gtgctgggat     3840

tacaggtgtg agccaccaca cccagccaac attttcctct tttaaaaaat atcttctcac     3900

gcctgtaatc ccagcacttt gggaggctga ggcaggcgga tcatgaggtc aggagatcaa     3960

gaccatcctg gctaacacgg tgaaactcca tctctactaa aaatacaaaa aaaatagccg     4020

ggcgtggtgg caggcgcctg tagtcccagc tactggggag gctgaggcag gaaaatggtg     4080

tcaacccggg aggcggagct tgcagtgagc cgagattgcg ccactgcact ccagcctggg     4140

caatagagtg agactccgtc tcaaaaaaaa aaaaaaaaaa aaaaacttca acaataccct     4200

caggttgata attttggata tctatctgta tctatatatc ttgtttacct ggtctccaga     4260

aaaagaacac atacacatat ccatatataa aatatgtata catgtatcaa atctacgtaa     4320

actataaagg tgggatggct ttaattatgg cccaagctac taagacaatg aagacttttt     4380

ggggctgcaa gctactgctt cccttcttta tctactagcc tcttaaacaa ggctcacttg     4440

tgctacaaga cagtccaccg ttttgttttt tttttctttt ttttgagaca gggtctcact     4500

ctttcccagg ctgcagtaca gtgacacagt ctcagctcac tgcagctttg accttgccgg     4560

gctcaggtga cccttacact tcagcctccc aagtagcagg gactataggt gtgcaccaac     4620

atgcttggtt aatttttgta ttttttgtag agacagggtt ttgccatgtt gtccaggcta     4680

gtctcgaatt cctgggctca agtgattcac ctgccttggc ctcccaaagt gctaggatta     4740

cagatgggag ccaccacgcc cagcccagtc cagctcttat atgtagcaca gggaaaggac     4800

aaatacttgt caactataaa taagaaacat tgctaatgca ttgcaaagaa cactagtttc     4860

atttacttta taacttagat gtctactggg tgagacgaat gtctttgttc tttaaaaaat     4920

aggaaaagag aagaaaaact agcataacat aagtactcat ttgtaagact ttctgacatg     4980

taacattagt tccgtagttt tgagacctgg tagaactgac tttcatattt ggataacctg     5040

gaaaacaccc aaacacaaac ttcaagtctt ctttctcttt tttcattatc ttttttagtc     5100

tgaggtgaca ccatcattaa ggattcgaca cccgtttgta aataaaatga catcagcaat     5160

tactctgaaa tgtttctagt ttgcaaagac ttagcaatgt gatgttatta acccttcctc     5220

ccttcagaga cctgtcctaa gctctgaacc actcattcct tccactcttc ttaccccagg     5280

tggttgatga gcagtggtcc ctggtgttcc acaaagagtc attaaagtgt tacagctggt     5340

agcactggta gcaaaaaaac aaaccaaaaa gtacacacag acacacacac acacacgcac     5400

acatacacac acacacgcac ttggccaagt gacaaaagct tggcccctga aatttctatg     5460

agatccgatg accaccaaca tcaaagcatt tttttttttt tttttttgag acgtagtctc     5520

gctctgtcac ccaggctaga gtgcagtggt gcaatcacag ctcactgcaa cctccacctc     5580

ccgggttcaa gcgattctcc tgcctcagcc tctcgagtag ctgtgactac aggcacctgc     5640

caccatgccc ggctaatttt ttgtattttt agtagagacg gggtttcacc gtgttagcca     5700

ggatggtctt gatctcctga cctcgtgatc catccgcctc ggcctcccaa attgctggga     5760

ttacaggcat gagccaccac gcccggccca tcaaaggaat tgtaacaact atttgagagc     5820

actgacaata agattaacac tcggttgatt tagatgttat gctggtcctc aggcattcat     5880

ctttagatat ttttggggtg gaagtggggt agggctgact tagtaaaaat aacctcttag     5940

cccaaaggct ttattcagac ttacaccgat ttgaggggtg ggtttgtgga atgcaaggtt     6000

aggttcttac ctaatatttg atgactaatt tagaatttta aatgtaattt taaattttag     6060

tgactggttt caaatctatt ttaacttcta gattgttcaa agaggtctca gtacatggct     6120

acaatcaaag tattagacta gctatttctc agctcagtgc tcagaaaaat tattactgtt     6180

gatacctttt tctttgtttc ctgttaaata aatcacctct ttaaagacag aaaaaaaaaa     6240

aaaa                                                                  6244


<210>  13
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  13
ggctgcttct tttggaggga gccagtgggg gacgggagtc tcagcaggct ggggtgttgc       60

acttttcctt ttgtctgcag cctgatgttt gctttgtgct gaaggaagac cgtgatgata      120

atcgtagcaa tcagccccaa atacaaacag gacgtggaag gcgctgagtc gcagctggac      180

gaggatgagc atggcttaca tactaagtac attcatcgaa tgatgcagat tgagttcata      240

aaacaaggaa gcatgaattt cagattcatc cctgtgctct tcccaaatgc taagaaggag      300

catgtgccca cctggcttca gaacactcat gtctacagct ggcccaagaa taaaaaaaac      360

atcctgctgc ggctgctgag agaggaagag tatgtggctc ctccacgggg gcctctgccc      420

acccttcagg tggttccctt gtgacaccgt tcatccccag atcactgagg ccaggccatg      480

tttggggcct tgttctgaca gcattctggc tgaggctggt cggtagcact cctggctggt      540

ttttttctgt tcctccccga gaggccctct ggcccccagg aaacctgttg tgcagagctc      600

ttccccggag acctccacac accctggctt tgaagtggag tctgtgactg ctctgcattc      660

tctgctttta aaaaaaccat tgcaggtgcc agtgtcccat atgttcctcc tgacagtttg      720

atgtgtccat tctgggcctc tcagtgctta gcaagtagat aatgtaaggg atgtggcagc      780

aaatggaaat gactacaaac actctcctat caatcacttc aggctacttt tatgagttag      840

ccagatgctt gtgtatcctc agaccaaact gattcatgta caaataataa aatgtttact      900

cttttgtaa                                                              909


<210>  14
<211>  4523
<212>  DNA
<213>  Homo sapiens

<400>  14
ataggaaaga aggaaatgaa ggcggagagt ggggagagag cagcagaatt caatttaatc       60

tgaggccacc ccaagtgttt tgtagaattg ggctgaagag gtttcctagg cagcctcgca      120

ggctgcacag cacaccaccc ccgagaagac cgtgatgata atcgtagcaa tcagccccaa      180

atacaaacag gacgtggaag gcgctgagtc gcagctggac gaggatgagc atggcttaca      240

tactaagtac attcatcgaa tgatgcagat tgagttcata aaacaaggaa gcatgaattt      300

cagattcatc cctgtgctct tcccaaatgc taagaaggag catgtgccca cctggcttca      360

gaacactcat gtctacagct ggcccaagaa taaaaaaaac atcctgctgc ggctgctgag      420

agaggaagag tatgtggctc ctccacgggg gcctctgccc acccttcagg tggttccctt      480

gtgacaccgt tcatccccag atcactgagg ccaggccatg tttggggcct tgttctgaca      540

gcattctggc tgaggctggt cggtagcact cctggctggt ttttttctgt tcctccccga      600

gaggccctct ggcccccagg aaacctgttg tgcagagctc ttccccggag acctccacac      660

accctggctt tgaagtggag tctgtgactg ctctgcattc tctgctttta aaaaaaccat      720

tgcaggtgcc agtgtcccat atgttcctcc tgacagtttg atgtgtccat tctgggcctc      780

tcagtgctta gcaagtagat aatgtaaggg atgtggcagc aaatggaaat gactacaaac      840

actctcctat caatcacttc aggctacttt tatgagttag ccagatgctt gtgtatcctc      900

agaccaaact gattcatgta caaataataa aatgtttact cttttgtaag attatgtttt      960

acttatctca aaggagatac atataattta taatgatatg ggcagttgct tccagggaca     1020

tcaacaaagc tgcttagata taatattaga taaatataac agaccactct gtattaatgg     1080

attaaagcca gctagttaaa caaccctttt taaccataat catggaagct ttattcttgc     1140

aataaagatt tttaggctgg gcgcagtgac tcacacctgt aatcccagca ctttgggaag     1200

ctaaggcagg cagatcattt gaggtcagga gtttgagacc agcctggcca acatggtgaa     1260

accccatctc tgctaaaatt acaaaaaagt tagccgggca tggtggtgtg cacctgtaat     1320

cccagctact cgggaggctg aggcaggaga atcacttgaa cccgggaggc agaggttgca     1380

gtgagccgag atcatgtcac tgcactctag cttgggagac agagcgagac tccgtctcaa     1440

aaaacaaaca aacaaataaa aacacccatt tttaacaaaa caactttata tagcatacag     1500

ccatgattct aaatagtatg attatggttc tcaggatctg actacatagg taaaaatatt     1560

tgcatatgtg tatgaagtgt tgggggatgt aggctagaat tgtagtctgt gttctaattt     1620

tggttctacc accaattagc tgtatgacct ttagcaagtc ctttaacttt tcttagattc     1680

cagggactca tttataaaat gacatggaca aaagcatctc taatcactct aaaagatttg     1740

aagtctagga cctaaattct aaatactctt ttgaggagtg actgagtttt cattttcata     1800

attatgtctc tcagaggaca aatttacatt ttcttaacag agacattttc ttcttctttt     1860

tttttgtttg agacagagtc tcgctctgtc gtccaggctg gagtgcagtg ctgcaatctt     1920

ggctcactgc aacctgcgcc tcctgggttc aagtgattct tctgcctcaa cctcccaagt     1980

agctagacct ataggcgcct gccaccatgc ccagctaatt tttgtatttt tagtagagac     2040

agggtttcat attggccaga ctggtctcga actcctgacc ttgtgatccg cccacctcgg     2100

cctcccaaag tgctgggatt acaggtgtga gccaccacac ccagccaaca ttttcctctt     2160

ttaaaaaata tcttctcacg cctgtaatcc cagcactttg ggaggctgag gcaggcggat     2220

catgaggtca ggagatcaag accatcctgg ctaacacggt gaaactccat ctctactaaa     2280

aatacaaaaa aaatagccgg gcgtggtggc aggcgcctgt agtcccagct actggggagg     2340

ctgaggcagg aaaatggtgt caacccggga ggcggagctt gcagtgagcc gagattgcgc     2400

cactgcactc cagcctgggc aatagagtga gactccgtct caaaaaaaaa aaaaaaaaaa     2460

aaaacttcaa caataccctc aggttgataa ttttggatat ctatctgtat ctatatatct     2520

tgtttacctg gtctccagaa aaagaacaca tacacatatc catatataaa atatgtatac     2580

atgtatcaaa tctacgtaaa ctataaaggt gggatggctt taattatggc ccaagctact     2640

aagacaatga agactttttg gggctgcaag ctactgcttc ccttctttat ctactagcct     2700

cttaaacaag gctcacttgt gctacaagac agtccaccgt tttgtttttt ttttcttttt     2760

tttgagacag ggtctcactc tttcccaggc tgcagtacag tgacacagtc tcagctcact     2820

gcagctttga ccttgccggg ctcaggtgac ccttacactt cagcctccca agtagcaggg     2880

actataggtg tgcaccaaca tgcttggtta atttttgtat tttttgtaga gacagggttt     2940

tgccatgttg tccaggctag tctcgaattc ctgggctcaa gtgattcacc tgccttggcc     3000

tcccaaagtg ctaggattac agatgggagc caccacgccc agcccagtcc agctcttata     3060

tgtagcacag ggaaaggaca aatacttgtc aactataaat aagaaacatt gctaatgcat     3120

tgcaaagaac actagtttca tttactttat aacttagatg tctactgggt gagacgaatg     3180

tctttgttct ttaaaaaata ggaaaagaga agaaaaacta gcataacata agtactcatt     3240

tgtaagactt tctgacatgt aacattagtt ccgtagtttt gagacctggt agaactgact     3300

ttcatatttg gataacctgg aaaacaccca aacacaaact tcaagtcttc tttctctttt     3360

ttcattatct tttttagtct gaggtgacac catcattaag gattcgacac ccgtttgtaa     3420

ataaaatgac atcagcaatt actctgaaat gtttctagtt tgcaaagact tagcaatgtg     3480

atgttattaa cccttcctcc cttcagagac ctgtcctaag ctctgaacca ctcattcctt     3540

ccactcttct taccccaggt ggttgatgag cagtggtccc tggtgttcca caaagagtca     3600

ttaaagtgtt acagctggta gcactggtag caaaaaaaca aaccaaaaag tacacacaga     3660

cacacacaca cacacgcaca catacacaca cacacgcact tggccaagtg acaaaagctt     3720

ggcccctgaa atttctatga gatccgatga ccaccaacat caaagcattt tttttttttt     3780

ttttttgaga cgtagtctcg ctctgtcacc caggctagag tgcagtggtg caatcacagc     3840

tcactgcaac ctccacctcc cgggttcaag cgattctcct gcctcagcct ctcgagtagc     3900

tgtgactaca ggcacctgcc accatgcccg gctaattttt tgtattttta gtagagacgg     3960

ggtttcaccg tgttagccag gatggtcttg atctcctgac ctcgtgatcc atccgcctcg     4020

gcctcccaaa ttgctgggat tacaggcatg agccaccacg cccggcccat caaaggaatt     4080

gtaacaacta tttgagagca ctgacaataa gattaacact cggttgattt agatgttatg     4140

ctggtcctca ggcattcatc tttagatatt tttggggtgg aagtggggta gggctgactt     4200

agtaaaaata acctcttagc ccaaaggctt tattcagact tacaccgatt tgaggggtgg     4260

gtttgtggaa tgcaaggtta ggttcttacc taatatttga tgactaattt agaattttaa     4320

atgtaatttt aaattttagt gactggtttc aaatctattt taacttctag attgttcaaa     4380

gaggtctcag tacatggcta caatcaaagt attagactag ctatttctca gctcagtgct     4440

cagaaaaatt attactgttg ataccttttt ctttgtttcc tgttaaataa atcacctctt     4500

taaagacaga aaaaaaaaaa aaa                                             4523


