                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       OLD DOMINION UNIVERSITY
       OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
       Lazo, John S.
       Sharlow, Elizabeth R.
       Catravas, John D.
       Colunga Biancatelli, Ruben ML
       Solopov, Pavel A.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING LUNG 
       INJURY

<130>  3062/153 PCT

<150>  US 63/174,750
<151>  2021-04-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2849
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (918)..(1439)

<400>  1
gtgcgcgagg gcgcgcgcgt cccgagccct ccacccgtcg tgccggcgcc gcccggaccg       60

ccagatgctg tgtgctgtgg acccacctgg ggttcatgga gtgggccacg gggcccagcc      120

ctaagcactg ctgcgcccag ggtcgccgcg cctcctgctg aggggtcccc gtgccactgg      180

ctctcaccat tgccctcgcc tgccgatggc ctctgctgcc cagcctgggg ccagctctac      240

cgcctgagcc ccctgcccca ctccaggact caccgtaccc cgatggggta acgtgacaca      300

ggccccacac gtcagaggcc gctgtcccca cggccactgc ccgtgacccc tggcccaagg      360

cagctggagt tggttcagtt caagttcatt cttcctctgg cccttggggg cttggggccc      420

acctctgagt gaagggggct gtctgcccat ccaccaatgt ggagagggcg cccccggtgt      480

ggggtccagc tctggacact gcttggcggc cgggttcact ttgagttttt aagttttctt      540

tgctgagctt ttttggttgt tctttttatt ttttgcctct ttatgactat ccagctctga      600

gagacgggag tttggagttg cccgctttac tttggttggg ttgggggggg cggcgggctg      660

ttttgttcct tttctttttt aagagttggg ttttcttttt taattatcca aacagtgggc      720

agcttcctcc cccacaccca agtatttgca caatatttgt gcggggtatg ggggtgggtt      780

tttaaatctc gtttctcttg gacaagcaca gggatctcgt tctcctcatt ttttgggggt      840

gtgtggggac ttctcaggtc gtgtccccag ccttctctgc agtcccttct gccctgccgg      900

gcccgtcggg aggcgcc atg gct cgg atg aac cgc ccg gcc ccg gtg gag         950
                   Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu            
                   1               5                   10                 

gtg agc tac aaa cac atg cgc ttc ctc atc acc cac aac ccc acc aac        998
Val Ser Tyr Lys His Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn           
            15                  20                  25                    

gcc acg ctc agc acc ttc att gag gac ctg aag aag tac ggg gct acc       1046
Ala Thr Leu Ser Thr Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr           
        30                  35                  40                        

act gtg gtg cgt gtg tgt gaa gtg acc tat gac aaa acg ccg ctg gag       1094
Thr Val Val Arg Val Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu           
    45                  50                  55                            

aag gat ggc atc acc gtt gtg gac tgg ccg ttt gac gat ggg gcg ccc       1142
Lys Asp Gly Ile Thr Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro           
60                  65                  70                  75            

ccg ccc ggc aag gta gtg gaa gac tgg ctg agc ctg gtg aag gcc aag       1190
Pro Pro Gly Lys Val Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys           
                80                  85                  90                

ttc tgt gag gcc ccc ggc agc tgc gtg gct gtg cac tgc gtg gcg ggc       1238
Phe Cys Glu Ala Pro Gly Ser Cys Val Ala Val His Cys Val Ala Gly           
            95                  100                 105                   

ctg ggc cgg gct cca gtc ctt gtg gcg ctg gcc ctt att gag agc ggg       1286
Leu Gly Arg Ala Pro Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly           
        110                 115                 120                       

atg aag tac gag gac gcc atc cag ttc atc cgc cag aag cgc cgc gga       1334
Met Lys Tyr Glu Asp Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly           
    125                 130                 135                           

gcc atc aac agc aag cag ctc acc tac ctg gag aaa tac cgg ccc aaa       1382
Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys           
140                 145                 150                 155           

cag agg ctg cgg ttc aaa gac cca cac acg cac aag acc cgg tgc tgc       1430
Gln Arg Leu Arg Phe Lys Asp Pro His Thr His Lys Thr Arg Cys Cys           
                160                 165                 170               

gtt atg tag ctcaggacct tggctgggcc tggtcgtcat gtaggtcagg               1479
Val Met                                                                   
                                                                          

accttggctg gacctggagg ccctgcccag ccctgctctg cccagcccag caggggctcc     1539

aggccttggc tggccccaca tcgccttttc ctccccgaca cctccgtgca cttgtgtccg     1599

aggagcgagg agcccctcgg gccctgggtg gcctctgggc cctttctcct gtctccgcca     1659

ctccctctgg cggcgctggc cgtggctctg tctctctgag gtgggtcggg cgccctctgc     1719

ccgccccctc ccacaccagc caggctggtc tcctctagcc tgtttgttgt ggggtggggg     1779

tatattttgt aaccactggg cccccagccc ctcttttgcg accccttgtc ctgacctgtt     1839

ctcggcacct taaattatta gaccccgggg cagtcaggtg ctccggacac ccgaaggcaa     1899

taaaacagga gccgtggccg tgtgtgtgga gtgggctaca gcgtcaggcg gggcgggctg     1959

gtggcctggg ggccccagag gctgctgtct ggatcctggg ctggtgccca ggatggggct     2019

cccgcgtgct cttgcgctgc cctctggtgg ccgctctggg tccttgcacc ccgacccagg     2079

ggccagcctg ccctgtcctg tcctgatacc gaggtgggag ccctgccttg gccagggtgg     2139

ccgtgttgac ggttcttggg actgtgacat tggaaggcga ggcaggtcac cagcactgtc     2199

ctctgcagga tgggctggga ttcatttggc agcttctcag ggcctgtgtc cggctggttg     2259

gtccctgtgc tgcccaaacc aggtgtccac atttccggct ccgaggcgca gagaaggggg     2319

caggtggtgg cttgggtgga ggaagtcacc atccatcagc ccagggaggg agggtgccac     2379

ctgggcacct ggggctggat gtgagaggcc tggaccaggg cccgccggag ggcgtggacc     2439

agatgctcat gtgttcctgg gtgcagtgtc tgtgttgggg gctggcccca ccctgggccg     2499

gggtgcatgg agggcatggc cccagcgggg aggaaggtgg gcctagggct ggctccaggg     2559

tgtggagagc ctgggagtgg tctccgtcct ggggccccag gaggttcccg caaggagcga     2619

ctggggcagg tgctggagga ggtcagtgga caagatgggg agatgtggaa accccaaaag     2679

ccccttctca ggcagccctg cccccaagac cgacagatgg ctaagggggc cgcagacctg     2739

gctcccccag ctcctgtgtg gagaaagggc aacagctgtc ccggatggtt attctctcct     2799

ttcctcaaac acatttggaa ctcaagtaaa tccaatgcat gttgggtgaa                2849


<210>  2
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
            100                 105                 110         


Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly Met Lys Tyr Glu Asp 
        115                 120                 125             


Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys 
    130                 135                 140                 


Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe 
145                 150                 155                 160 


Lys Asp Pro His Thr His Lys Thr Arg Cys Cys Val Met 
                165                 170             


<210>  3
<211>  2710
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (854)..(1300)

<400>  3
atgctgtgtg ctgtggaccc acctggggtt catggagtgg gccacggggc ccagccctaa       60

gcactgctgc gcccagggtc gccgcgcctc ctgctgaggg gtccccgtgc cactggctct      120

caccattgcc ctcgcctgcc gatggcctct gctgcccagc ctggggccag ctctaccgcc      180

tgagccccct gccccactcc aggactcacc gtaccccgat ggggtaacgt gacacaggcc      240

ccacacgtca gaggccgctg tccccacggc cactgcccgt gacccctggc ccaaggcagc      300

tggagttggt tcagttcaag ttcattcttc ctctggccct tgggggcttg gggcccacct      360

ctgagtgaag ggggctgtct gcccatccac caatgtggag agggcgcccc cggtgtgggg      420

tccagctctg gacactgctt ggcggccggg ttcactttga gtttttaagt tttctttgct      480

gagctttttt ggttgttctt tttatttttt gcctctttat gactatccag ctctgagaga      540

cgggagtttg gagttgcccg ctttactttg gttgggttgg ggggggcggc gggctgtttt      600

gttccttttc ttttttaaga gttgggtttt cttttttaat tatccaaaca gtgggcagct      660

tcctccccca cacccaagta tttgcacaat atttgtgcgg ggtatggggg tgggttttta      720

aatctcgttt ctcttggaca agcacaggga tctcgttctc ctcatttttt gggggtgtgt      780

ggggacttct caggtcgtgt ccccagcctt ctctgcagtc ccttctgccc tgccgggccc      840

gtcgggaggc gcc atg gct cgg atg aac cgc ccg gcc ccg gtg gag gtg         889
               Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val            
               1               5                   10                     

agc tac aaa cac atg cgc ttc ctc atc acc cac aac ccc acc aac gcc        937
Ser Tyr Lys His Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala           
        15                  20                  25                        

acg ctc agc acc ttc att gag gac ctg aag aag tac ggg gct acc act        985
Thr Leu Ser Thr Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr           
    30                  35                  40                            

gtg gtg cgt gtg tgt gaa gtg acc tat gac aaa acg ccg ctg gag aag       1033
Val Val Arg Val Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys           
45                  50                  55                  60            

gat ggc atc acc gtt gtg gac tgg ccg ttt gac gat ggg gcg ccc ccg       1081
Asp Gly Ile Thr Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro           
                65                  70                  75                

ccc ggc aag gta gtg gaa gac tgg ctg agc ctg gtg aag gcc aag ttc       1129
Pro Gly Lys Val Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe           
            80                  85                  90                    

tgt gag gcc ccc ggc agc tgc gtg gct gtg cac tgc gtg gcg ggc ctg       1177
Cys Glu Ala Pro Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu           
        95                  100                 105                       

ggc cgg aag cgc cgc gga gcc atc aac agc aag cag ctc acc tac ctg       1225
Gly Arg Lys Arg Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu           
    110                 115                 120                           

gag aaa tac cgg ccc aaa cag agg ctg cgg ttc aaa gac cca cac acg       1273
Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr           
125                 130                 135                 140           

cac aag acc cgg tgc tgc gtt atg tag ctcaggacct tggctgggcc             1320
His Lys Thr Arg Cys Cys Val Met                                           
                145                                                       

tggtcgtcat gtaggtcagg accttggctg gacctggagg ccctgcccag ccctgctctg     1380

cccagcccag caggggctcc aggccttggc tggccccaca tcgccttttc ctccccgaca     1440

cctccgtgca cttgtgtccg aggagcgagg agcccctcgg gccctgggtg gcctctgggc     1500

cctttctcct gtctccgcca ctccctctgg cggcgctggc cgtggctctg tctctctgag     1560

gtgggtcggg cgccctctgc ccgccccctc ccacaccagc caggctggtc tcctctagcc     1620

tgtttgttgt ggggtggggg tatattttgt aaccactggg cccccagccc ctcttttgcg     1680

accccttgtc ctgacctgtt ctcggcacct taaattatta gaccccgggg cagtcaggtg     1740

ctccggacac ccgaaggcaa taaaacagga gccgtggccg tgtgtgtgga gtgggctaca     1800

gcgtcaggcg gggcgggctg gtggcctggg ggccccagag gctgctgtct ggatcctggg     1860

ctggtgccca ggatggggct cccgcgtgct cttgcgctgc cctctggtgg ccgctctggg     1920

tccttgcacc ccgacccagg ggccagcctg ccctgtcctg tcctgatacc gaggtgggag     1980

ccctgccttg gccagggtgg ccgtgttgac ggttcttggg actgtgacat tggaaggcga     2040

ggcaggtcac cagcactgtc ctctgcagga tgggctggga ttcatttggc agcttctcag     2100

ggcctgtgtc cggctggttg gtccctgtgc tgcccaaacc aggtgtccac atttccggct     2160

ccgaggcgca gagaaggggg caggtggtgg cttgggtgga ggaagtcacc atccatcagc     2220

ccagggaggg agggtgccac ctgggcacct ggggctggat gtgagaggcc tggaccaggg     2280

cccgccggag ggcgtggacc agatgctcat gtgttcctgg gtgcagtgtc tgtgttgggg     2340

gctggcccca ccctgggccg gggtgcatgg agggcatggc cccagcgggg aggaaggtgg     2400

gcctagggct ggctccaggg tgtggagagc ctgggagtgg tctccgtcct ggggccccag     2460

gaggttcccg caaggagcga ctggggcagg tgctggagga ggtcagtgga caagatgggg     2520

agatgtggaa accccaaaag ccccttctca ggcagccctg cccccaagac cgacagatgg     2580

ctaagggggc cgcagacctg gctcccccag ctcctgtgtg gagaaagggc aacagctgtc     2640

ccggatggtt attctctcct ttcctcaaac acatttggaa ctcaagtaaa tccaatgcat     2700

gttgggtgaa                                                            2710


<210>  4
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Lys Arg 
            100                 105                 110         


Arg Gly Ala Ile Asn Ser Lys Gln Leu Thr Tyr Leu Glu Lys Tyr Arg 
        115                 120                 125             


Pro Lys Gln Arg Leu Arg Phe Lys Asp Pro His Thr His Lys Thr Arg 
    130                 135                 140                 


Cys Cys Val Met 
145             


