                         SEQUENCE LISTING

<110>  PALLEON PHARMACEUTICALS INC.
 
<120>  ANTI-INFLAMMATORY SIGLEC PROTEINS AND METHODS OF MAKING AND USING
        SAME

<130>  PAL-026WO

<140>  PCT/US2022/025087
<141>  2022-04-15

<150>  US 63/175,826
<151>  2021-04-16

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(227)
<223>  hIgG1 Fc - Shorter (No N-terminal EPKSC)

<400>  1

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  2
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - Hole (Y407T) - Shorter

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  3
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - Knob (T366Y) - Shorter

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - N297G - Shorter

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(232)
<223>  hIgG1 Fc - Longer (N-terminal EPKSC)

<400>  5

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  6
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - Knob (T366Y) - Longer

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - Hole (Y407T) - Longer

<400>  7

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  8
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc - N297G - Longer

<400>  8

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  10

Gly Gly Gly Gly Ser 
1               5   


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  12

Glu Pro Lys Ser Ser 
1               5   


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  REPEAT
<222>  (1)..(15)
<223>  "Gly Gly Pro" is present at least once and may repeat up to five 
       times

<400>  13

Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro 
1               5                   10                  15  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  REPEAT
<222>  (1)..(25)
<223>  "Gly Gly Gly Gly Ser" is present at least once and may repeat up 
       to five times

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  15
<211>  1709
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1709)
<223>  Siglec 1 FL

<400>  15

Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala 
1               5                   10                  15      


Gly Gln Ala Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val 
            20                  25                  30          


Lys Gly Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp 
        35                  40                  45              


Val Glu Val Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser 
    50                  55                  60                  


Gly Gln Arg Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu 
65                  70                  75                  80  


Ala Arg Phe Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg 
                85                  90                  95      


Val Cys Asn Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser 
            100                 105                 110         


Tyr Asn Phe Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val 
        115                 120                 125             


Lys Gly Thr Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile 
    130                 135                 140                 


Ala Ser Pro Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys 
145                 150                 155                 160 


Ser Thr Pro Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln 
                165                 170                 175     


Gly Gln Asp Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu 
            180                 185                 190         


Pro Thr Gly Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp 
        195                 200                 205             


Gln Asp His Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His 
    210                 215                 220                 


Arg Ala Gln Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly 
225                 230                 235                 240 


Val Lys Ile Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu 
                245                 250                 255     


Leu Val Thr Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser 
            260                 265                 270         


Ser Ile Lys Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly 
        275                 280                 285             


Val Leu His Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr 
    290                 295                 300                 


Cys Gln Ala Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser 
305                 310                 315                 320 


Leu His Ile Phe Met Ala Glu Val Gln Val Ser Pro Ala Gly Pro Ile 
                325                 330                 335     


Leu Glu Asn Gln Thr Val Thr Leu Val Cys Asn Thr Pro Asn Glu Ala 
            340                 345                 350         


Pro Ser Asp Leu Arg Tyr Ser Trp Tyr Lys Asn His Val Leu Leu Glu 
        355                 360                 365             


Asp Ala His Ser His Thr Leu Arg Leu His Leu Ala Thr Arg Ala Asp 
    370                 375                 380                 


Thr Gly Phe Tyr Phe Cys Glu Val Gln Asn Val His Gly Ser Glu Arg 
385                 390                 395                 400 


Ser Gly Pro Val Ser Val Val Val Asn His Pro Pro Leu Thr Pro Val 
                405                 410                 415     


Leu Thr Ala Phe Leu Glu Thr Gln Ala Gly Leu Val Gly Ile Leu His 
            420                 425                 430         


Cys Ser Val Val Ser Glu Pro Leu Ala Thr Leu Val Leu Ser His Gly 
        435                 440                 445             


Gly His Ile Leu Ala Ser Thr Ser Gly Asp Ser Asp His Ser Pro Arg 
    450                 455                 460                 


Phe Ser Gly Thr Ser Gly Pro Asn Ser Leu Arg Leu Glu Ile Arg Asp 
465                 470                 475                 480 


Leu Glu Glu Thr Asp Ser Gly Glu Tyr Lys Cys Ser Ala Thr Asn Ser 
                485                 490                 495     


Leu Gly Asn Ala Thr Ser Thr Leu Asp Phe His Ala Asn Ala Ala Arg 
            500                 505                 510         


Leu Leu Ile Ser Pro Ala Ala Glu Val Val Glu Gly Gln Ala Val Thr 
        515                 520                 525             


Leu Ser Cys Arg Ser Gly Leu Ser Pro Thr Pro Asp Ala Arg Phe Ser 
    530                 535                 540                 


Trp Tyr Leu Asn Gly Ala Leu Leu His Glu Gly Pro Gly Ser Ser Leu 
545                 550                 555                 560 


Leu Leu Pro Ala Ala Ser Ser Thr Asp Ala Gly Ser Tyr His Cys Arg 
                565                 570                 575     


Ala Arg Asp Gly His Ser Ala Ser Gly Pro Ser Ser Pro Ala Val Leu 
            580                 585                 590         


Thr Val Leu Tyr Pro Pro Arg Gln Pro Thr Phe Thr Thr Arg Leu Asp 
        595                 600                 605             


Leu Asp Ala Ala Gly Ala Gly Ala Gly Arg Arg Gly Leu Leu Leu Cys 
    610                 615                 620                 


Arg Val Asp Ser Asp Pro Pro Ala Arg Leu Gln Leu Leu His Lys Asp 
625                 630                 635                 640 


Arg Val Val Ala Thr Ser Leu Pro Ser Gly Gly Gly Cys Ser Thr Cys 
                645                 650                 655     


Gly Gly Cys Ser Pro Arg Met Lys Val Thr Lys Ala Pro Asn Leu Leu 
            660                 665                 670         


Arg Val Glu Ile His Asn Pro Leu Leu Glu Glu Glu Gly Leu Tyr Leu 
        675                 680                 685             


Cys Glu Ala Ser Asn Ala Leu Gly Asn Ala Ser Thr Ser Ala Thr Phe 
    690                 695                 700                 


Asn Gly Gln Ala Thr Val Leu Ala Ile Ala Pro Ser His Thr Leu Gln 
705                 710                 715                 720 


Glu Gly Thr Glu Ala Asn Leu Thr Cys Asn Val Ser Arg Glu Ala Ala 
                725                 730                 735     


Gly Ser Pro Ala Asn Phe Ser Trp Phe Arg Asn Gly Val Leu Trp Ala 
            740                 745                 750         


Gln Gly Pro Leu Glu Thr Val Thr Leu Leu Pro Val Ala Arg Thr Asp 
        755                 760                 765             


Ala Ala Leu Tyr Ala Cys Arg Ile Leu Thr Glu Ala Gly Ala Gln Leu 
    770                 775                 780                 


Ser Thr Pro Val Leu Leu Ser Val Leu Tyr Pro Pro Asp Arg Pro Lys 
785                 790                 795                 800 


Leu Ser Ala Leu Leu Asp Met Gly Gln Gly His Met Ala Leu Phe Ile 
                805                 810                 815     


Cys Thr Val Asp Ser Arg Pro Leu Ala Leu Leu Ala Leu Phe His Gly 
            820                 825                 830         


Glu His Leu Leu Ala Thr Ser Leu Gly Pro Gln Val Pro Ser His Gly 
        835                 840                 845             


Arg Phe Gln Ala Lys Ala Glu Ala Asn Ser Leu Lys Leu Glu Val Arg 
    850                 855                 860                 


Glu Leu Gly Leu Gly Asp Ser Gly Ser Tyr Arg Cys Glu Ala Thr Asn 
865                 870                 875                 880 


Val Leu Gly Ser Ser Asn Thr Ser Leu Phe Phe Gln Val Arg Gly Ala 
                885                 890                 895     


Trp Val Gln Val Ser Pro Ser Pro Glu Leu Gln Glu Gly Gln Ala Val 
            900                 905                 910         


Val Leu Ser Cys Gln Val His Thr Gly Val Pro Glu Gly Thr Ser Tyr 
        915                 920                 925             


Arg Trp Tyr Arg Asp Gly Gln Pro Leu Gln Glu Ser Thr Ser Ala Thr 
    930                 935                 940                 


Leu Arg Phe Ala Ala Ile Thr Leu Thr Gln Ala Gly Ala Tyr His Cys 
945                 950                 955                 960 


Gln Ala Gln Ala Pro Gly Ser Ala Thr Thr Ser Leu Ala Ala Pro Ile 
                965                 970                 975     


Ser Leu His Val Ser Tyr Ala Pro Arg His Val Thr Leu Thr Thr Leu 
            980                 985                 990         


Met Asp Thr Gly Pro Gly Arg Leu  Gly Leu Leu Leu Cys  Arg Val Asp 
        995                 1000                 1005             


Ser Asp  Pro Pro Ala Gln Leu  Arg Leu Leu His Gly  Asp Arg Leu 
    1010                 1015                 1020             


Val Ala  Ser Thr Leu Gln Gly  Val Gly Gly Pro Glu  Gly Ser Ser 
    1025                 1030                 1035             


Pro Arg  Leu His Val Ala Val  Ala Pro Asn Thr Leu  Arg Leu Glu 
    1040                 1045                 1050             


Ile His  Gly Ala Met Leu Glu  Asp Glu Gly Val Tyr  Ile Cys Glu 
    1055                 1060                 1065             


Ala Ser  Asn Thr Leu Gly Gln  Ala Ser Ala Ser Ala  Asp Phe Asp 
    1070                 1075                 1080             


Ala Gln  Ala Val Asn Val Gln  Val Trp Pro Gly Ala  Thr Val Arg 
    1085                 1090                 1095             


Glu Gly  Gln Leu Val Asn Leu  Thr Cys Leu Val Trp  Thr Thr His 
    1100                 1105                 1110             


Pro Ala  Gln Leu Thr Tyr Thr  Trp Tyr Gln Asp Gly  Gln Gln Arg 
    1115                 1120                 1125             


Leu Asp  Ala His Ser Ile Pro  Leu Pro Asn Val Thr  Val Arg Asp 
    1130                 1135                 1140             


Ala Thr  Ser Tyr Arg Cys Gly  Val Gly Pro Pro Gly  Arg Ala Pro 
    1145                 1150                 1155             


Arg Leu  Ser Arg Pro Ile Thr  Leu Asp Val Leu Tyr  Ala Pro Arg 
    1160                 1165                 1170             


Asn Leu  Arg Leu Thr Tyr Leu  Leu Glu Ser His Gly  Gly Gln Leu 
    1175                 1180                 1185             


Ala Leu  Val Leu Cys Thr Val  Asp Ser Arg Pro Pro  Ala Gln Leu 
    1190                 1195                 1200             


Ala Leu  Ser His Ala Gly Arg  Leu Leu Ala Ser Ser  Thr Ala Ala 
    1205                 1210                 1215             


Ser Val  Pro Asn Thr Leu Arg  Leu Glu Leu Arg Gly  Pro Gln Pro 
    1220                 1225                 1230             


Arg Asp  Glu Gly Phe Tyr Ser  Cys Ser Ala Arg Ser  Pro Leu Gly 
    1235                 1240                 1245             


Gln Ala  Asn Thr Ser Leu Glu  Leu Arg Leu Glu Gly  Val Arg Val 
    1250                 1255                 1260             


Ile Leu  Ala Pro Glu Ala Ala  Val Pro Glu Gly Ala  Pro Ile Thr 
    1265                 1270                 1275             


Val Thr  Cys Ala Asp Pro Ala  Ala His Ala Pro Thr  Leu Tyr Thr 
    1280                 1285                 1290             


Trp Tyr  His Asn Gly Arg Trp  Leu Gln Glu Gly Pro  Ala Ala Ser 
    1295                 1300                 1305             


Leu Ser  Phe Leu Val Ala Thr  Arg Ala His Ala Gly  Ala Tyr Ser 
    1310                 1315                 1320             


Cys Gln  Ala Gln Asp Ala Gln  Gly Thr Arg Ser Ser  Arg Pro Ala 
    1325                 1330                 1335             


Ala Leu  Gln Val Leu Tyr Ala  Pro Gln Asp Ala Val  Leu Ser Ser 
    1340                 1345                 1350             


Phe Arg  Asp Ser Arg Ala Arg  Ser Met Ala Val Ile  Gln Cys Thr 
    1355                 1360                 1365             


Val Asp  Ser Glu Pro Pro Ala  Glu Leu Ala Leu Ser  His Asp Gly 
    1370                 1375                 1380             


Lys Val  Leu Ala Thr Ser Ser  Gly Val His Ser Leu  Ala Ser Gly 
    1385                 1390                 1395             


Thr Gly  His Val Gln Val Ala  Arg Asn Ala Leu Arg  Leu Gln Val 
    1400                 1405                 1410             


Gln Asp  Val Pro Ala Gly Asp  Asp Thr Tyr Val Cys  Thr Ala Gln 
    1415                 1420                 1425             


Asn Leu  Leu Gly Ser Ile Ser  Thr Ile Gly Arg Leu  Gln Val Glu 
    1430                 1435                 1440             


Gly Ala  Arg Val Val Ala Glu  Pro Gly Leu Asp Val  Pro Glu Gly 
    1445                 1450                 1455             


Ala Ala  Leu Asn Leu Ser Cys  Arg Leu Leu Gly Gly  Pro Gly Pro 
    1460                 1465                 1470             


Val Gly  Asn Ser Thr Phe Ala  Trp Phe Trp Asn Asp  Arg Arg Leu 
    1475                 1480                 1485             


His Ala  Glu Pro Val Pro Thr  Leu Ala Phe Thr His  Val Ala Arg 
    1490                 1495                 1500             


Ala Gln  Ala Gly Met Tyr His  Cys Leu Ala Glu Leu  Pro Thr Gly 
    1505                 1510                 1515             


Ala Ala  Ala Ser Ala Pro Val  Met Leu Arg Val Leu  Tyr Pro Pro 
    1520                 1525                 1530             


Lys Thr  Pro Thr Met Met Val  Phe Val Glu Pro Glu  Gly Gly Leu 
    1535                 1540                 1545             


Arg Gly  Ile Leu Asp Cys Arg  Val Asp Ser Glu Pro  Leu Ala Ser 
    1550                 1555                 1560             


Leu Thr  Leu His Leu Gly Ser  Arg Leu Val Ala Ser  Ser Gln Pro 
    1565                 1570                 1575             


Gln Gly  Ala Pro Ala Glu Pro  His Ile His Val Leu  Ala Ser Pro 
    1580                 1585                 1590             


Asn Ala  Leu Arg Val Asp Ile  Glu Ala Leu Arg Pro  Ser Asp Gln 
    1595                 1600                 1605             


Gly Glu  Tyr Ile Cys Ser Ala  Ser Asn Val Leu Gly  Ser Ala Ser 
    1610                 1615                 1620             


Thr Ser  Thr Tyr Phe Gly Val  Arg Ala Leu His Arg  Leu His Gln 
    1625                 1630                 1635             


Phe Gln  Gln Leu Leu Trp Val  Leu Gly Leu Leu Val  Gly Leu Leu 
    1640                 1645                 1650             


Leu Leu  Leu Leu Gly Leu Gly  Ala Cys Tyr Thr Trp  Arg Arg Arg 
    1655                 1660                 1665             


Arg Val  Cys Lys Gln Ser Met  Gly Glu Asn Ser Val  Glu Met Ala 
    1670                 1675                 1680             


Phe Gln  Lys Glu Thr Thr Gln  Leu Ile Asp Pro Asp  Ala Ala Thr 
    1685                 1690                 1695             


Cys Glu  Thr Ser Thr Cys Ala  Pro Pro Leu Gly 
    1700                 1705                 


<210>  16
<211>  6736
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6736)
<223>  Siglec 1 FL

<400>  16
atgggcttct tgcccaagct tctcctcctg gcctcattct tcccagcagg ccaggcctca       60

tggggcgtct ccagtcccca ggacgtgcag ggtgtgaagg ggtcttgcct gcttatcccc      120

tgcatcttca gcttccctgc cgacgtggag gtgcccgacg gcatcacggc catctggtac      180

tacgactact cgggccagcg gcaggtggtg agccactcgg cggaccccaa gctggtggag      240

gcccgcttcc gcggccgcac cgagttcatg gggaaccccg agcacagggt gtgcaacctg      300

ctgctgaagg acctgcagcc cgaggactct ggttcctaca acttccgctt cgagatcagt      360

gaggtcaacc gctggtcaga tgtgaaaggc accttggtca cagtaacaga ggagcccagg      420

gtgcccacca ttgcctcccc ggtggagctt ctcgagggca cagaggtgga cttcaactgc      480

tccactccct acgtatgcct gcaggagcag gtcagactgc agtggcaagg ccaggaccct      540

gctcgctctg tcaccttcaa cagccagaag tttgagccca ccggcgtcgg ccacctggag      600

accctccaca tggccatgtc ctggcaggac cacggccgga tcctgcgctg ccagctctcc      660

gtggccaatc acagggctca gagcgagatt cacctccaag tgaagtatgc ccccaagggt      720

gtgaagatcc tcctcagccc ctcggggagg aacatccttc caggtgagct ggtcacactc      780

acctgccagg tgaacagcag ctaccctgca gtcagttcca ttaagtggct caaggatggg      840

gtacgcctcc aaaccaagac tggtgtgctg cacctgcccc aggcagcctg gagcgatgct      900

ggcgtctaca cctgccaagc tgagaacggc gtgggctctt tggtctcacc ccccatcagc      960

ctccacatct tcatggctga ggtccaggtg agcccagcag gtcccatcct ggagaaccag     1020

acagtgacac tagtctgcaa cacacccaat gaggcaccca gtgatctccg ctacagctgg     1080

tacaagaacc atgtcctgct ggaggatgcc cactcccata ccctccggct gcacttggcc     1140

actagggctg atactggctt ctacttctgt gaggtgcaga acgtccatgg cagcgagcgc     1200

tcgggccctg tcagcgtggt agtcaaccac ccgcctctca ctccagtcct gacagccttc     1260

ctggagaccc aggcgggact tgtgggcatc cttcactgct ctgtggtcag tgagcccctg     1320

gccacactgg tgctgtcaca tgggggtcat atcctggcct ccacctccgg ggacagtgat     1380

cacagcccac gcttcagtgg tacctctggt cccaactccc tgcgcctgga gatccgagac     1440

ctggaggaaa ctgacagtgg ggagtacaag tgctcagcca ccaactccct tggaaatgca     1500

acctccaccc tggacttcca tgccaatgcc gcccgtctcc tcatcagccc ggcagccgag     1560

gtggtggaag gacaggcagt gacactgagc tgcagaagcg gcctaagccc cacacctgat     1620

gcccgcttct cctggtacct gaatggagcc ctgcttcacg agggtcccgg cagcagcctc     1680

ctgctccccg cggcctccag cactgacgcc ggctcatacc actgccgggc ccgggacggc     1740

cacagtgcca gtggcccctc ttcgccagct gttctcactg tgctctaccc ccctcgacaa     1800

ccaacattca ccaccaggct ggaccttgat gccgctgggg ccggggctgg acggcgaggc     1860

ctccttttgt gccgtgtgga cagcgacccc cccgccaggc tgcagctgct ccacaaggac     1920

cgtgttgtgg ccacttccct gccatcaggg ggtggctgca gcacctgtgg gggctgttcc     1980

ccacgcatga aggtcaccaa agcccccaac ttgctgcgtg tggagattca caaccctttg     2040

ctggaagagg agggcttgta cctctgtgag gccagcaatg ccctgggcaa cgcctccacc     2100

tcagccacct tcaatggcca ggccactgtc ctggccattg caccatcaca cacacttcag     2160

gagggcacag aagccaactt gacttgcaac gtgagccggg aagctgctgg cagccctgct     2220

aacttctcct ggttccgaaa tggggtgctg tgggcccagg gtcccctgga gaccgtgaca     2280

ctgctgcccg tggccagaac tgatgctgcc ctttacgcct gccgcatcct gactgaggct     2340

ggtgcccagc tctccactcc cgtgctcctg agtgtactct atcccccgga ccgtccaaag     2400

ctgtcagccc tcctagacat gggccagggc cacatggctc tgttcatctg cactgtggac     2460

agccgccccc tggccttgct ggccttgttc catggggagc acctcctggc caccagcctg     2520

ggtccccagg tcccatccca tggtcggttc caggctaaag ctgaggccaa ctccctgaag     2580

ttagaggtcc gagaactggg ccttggggac tctggcagct accgctgtga ggccacaaat     2640

gttcttggat catccaacac ctcactcttc ttccaggtcc gaggagcctg ggtccaggtg     2700

tcaccatcac ctgagctcca agagggccag gctgtggtcc tgagctgcca ggtacacaca     2760

ggagtcccag aggggacctc atatcgttgg tatcgggatg gccagcccct ccaggagtcg     2820

acctcggcca cgctccgctt tgcagccata actttgacac aagctggggc ctatcattgc     2880

caagcccagg ccccaggctc agccaccacg agcctagctg cacccatcag cctccacgtg     2940

tcctatgccc cacgccacgt cacactcact accctgatgg acacaggccc tggacgactg     3000

ggcctcctcc tgtgccgtgt ggacagtgac cctccggccc agctgcggct gctccacggg     3060

gatcgccttg tggcctccac cctacaaggt gtggggggac ccgaaggcag ctctcccagg     3120

ctgcatgtgg ctgtggcccc caacacactg cgtctggaga tccacggggc tatgctggag     3180

gatgagggtg tctatatctg tgaggcctcc aacaccctgg gccaggcctc ggcctcagct     3240

gacttcgacg ctcaagctgt gaatgtgcag gtgtggcccg gggctaccgt gcgggagggg     3300

cagctggtga acctgacctg ccttgtgtgg accactcacc cggcccagct cacctacaca     3360

tggtaccagg atgggcagca gcgcctggat gcccactcca tccccctgcc caacgtcaca     3420

gtcagggatg ccacctccta ccgctgcggt gtgggccccc ctggtcgggc accccgcctc     3480

tccagaccta tcaccttgga cgtcctctac gcgccccgca acctgcgcct gacctacctc     3540

ctggagagcc atggcgggca gctggccctg gtactgtgca ctgtggacag ccgcccgccc     3600

gcccagctgg ccctcagcca cgccggtcgc ctcttggcct cctcgacagc agcctctgtc     3660

cccaacaccc tgcgcctgga gctgcgaggg ccacagccca gggatgaggg tttctacagc     3720

tgctctgccc gcagccctct gggccaggcc aacacgtccc tggagctgcg gctggagggt     3780

gtgcgggtga tcctggctcc ggaggctgcc gtgcctgaag gtgcccccat cacagtgacc     3840

tgtgcggacc ctgctgccca cgcacccaca ctctatactt ggtaccacaa cggtcgttgg     3900

ctgcaggagg gtccagctgc ctcactctca ttcctggtgg ccacgcgggc tcatgcaggc     3960

gcctactctt gccaggccca ggatgcccag ggcacccgca gctcccgtcc tgctgccctg     4020

caagtcctct atgcccctca ggacgctgtc ctgtcctcct tccgggactc cagggccaga     4080

tccatggctg tgatacagtg cactgtggac agtgagccac ctgctgagct ggccctatct     4140

catgatggca aggtgctggc cacgagcagc ggggtccaca gcttggcatc agggacaggc     4200

catgtccagg tggcccgaaa cgccctacgg ctgcaggtgc aagatgtgcc tgcaggtgat     4260

gacacctatg tttgcacagc ccaaaacttg ctgggctcaa tcagcaccat cgggcggttg     4320

caggtagaag gtgcacgcgt ggtggcagag cctggcctgg acgtgcctga gggcgctgcc     4380

ctgaacctca gctgccgcct cctgggtggc cctgggcctg tgggcaactc cacctttgca     4440

tggttctgga atgaccggcg gctgcacgcg gagcctgtgc ccactctcgc cttcacccac     4500

gtggctcgtg ctcaagctgg gatgtaccac tgcctggctg agctccccac tggggctgct     4560

gcctctgctc cagtcatgct ccgtgtgctc taccctccca agacgcccac catgatggtc     4620

ttcgtggagc ctgagggtgg cctccggggc atcctggatt gccgagtgga cagcgagccg     4680

ctcgccagcc tgactctcca ccttggcagt cgactggtgg cctccagtca gccccagggt     4740

gctcctgcag agccacacat ccatgtcctg gcttccccca atgccctgag ggtggacatc     4800

gaggcgctga ggcccagcga ccaaggggaa tacatctgtt ctgcctcaaa tgtcctgggc     4860

tctgcctcta cctccaccta ctttggggtc agagccctgc accgcctgca tcagttccag     4920

cagctgctct gggtcctggg actgctggtg ggcctcctgc tcctgctgtt gggcctgggg     4980

gcctgctaca cctggagaag gaggcgtgtt tgtaagcaga gcatgggcga gaattcggtg     5040

gagatggctt ttcagaaaga gaccacgcag ctcattgatc ctgatgcagc cacatgtgag     5100

acctcaacct gtgccccacc cctgggctga ccagtggtgt tgcctgccct ccggaggaga     5160

aagtggccag aatctgtgat gactccagcc tatgaatgtg aatgaggcag tgttgagtcc     5220

tgcccgcctc tacgaaaaca gctctgtgac atctgacttt ttatgacctg gccccaagcc     5280

tcttgccccc ccaaaaatgg gtggtgagag gtctgcccag gagggtgttg accctggagg     5340

acactgaaga gcactgagct gatctcgctc tctcttctct ggatctcctc ccttctctcc     5400

atttctccct caaaggaagc cctgcccttt cacatccttc tcctcgaaag tcaccctgga     5460

ctttggttgg attgcagcat cctgcatcct cagaggctca ccaaggcatt ctgtattcaa     5520

cagagtatca gtcagcctgc tctaacaaga gaccaaatac agtgacttca acatgataga     5580

attttatttt tctctcccac gctagtctgg ctgttacgat ggtttatgat gttggggctc     5640

aggatccttc tatcttcctt ttctctatcc ctaaaatgat gcctttgatt gtgaggctca     5700

ccatggcccc gctttgtcca catgccctcc agccagaaga aggaagagtg gaggtagaag     5760

cacacccatg cccatggtgg acgcaactca gaagctgcac aggacttttc cactcacttc     5820

ccattggctg gagtattgtc acatggctac tgcaagctac aagggagact gggaaatgta     5880

gtttttattt tgagtccaga ggacatttgg aattggactt ccaaaggact cccaactgtg     5940

agctcatccc tgagactttt gacattgttg ggaatgccac cagcaggcca tgttttgtct     6000

cagtgcccat ctactgaggg ccagggtgtg cccctggcca ttctggttgt gggcttcctg     6060

gaagaggtga tcactctcac actaagactg aggaaataaa aaaggtttgg tgttttccta     6120

gggagagagc atgccaggca gtggagttgc ctaagcagac atccttgtgc cagatttggc     6180

ccctgaaaga agagatgccc tcattcccac caccaccccc cctaccccca gggactgggt     6240

actaccttac tggcccttac aagagtggag ggcagacaca gatgttgtca gcatccttat     6300

tcctgctcca gatgcatctc tgttcatgac tgtgtgagct cctgtccttt tcctggagac     6360

cctgtgtcgg gctgttaaag agaatgagtt accaagaagg aatgacgtgc ccctgcgaat     6420

cagggaccaa caggagagag ctcttgagtg ggctagtgac tccccctgca gcctggtgga     6480

gatggtgtga ggagcgaaga gccctctgct ctaggatttg ggttgaaaaa cagagagaga     6540

agtggggagt tgccacagga gctaacacgc tgggaggcag ttgggggcgg gtgaactttg     6600

tgtagccgag gccgcaccct ccctcattcc aggctcattc attttcatgc tccattgcca     6660

gactcttgct gggagcccgt ccagaatgtc ctcccaataa aactccatcc tatgacgcaa     6720

aaaaaaaaaa aaaaaa                                                     6736


<210>  17
<211>  301
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(301)
<223>  Siglec 1 Fragment (20-320)

<400>  17

Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val Lys Gly Ser 
1               5                   10                  15      


Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp Val Glu Val 
            20                  25                  30          


Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Gln Arg 
        35                  40                  45              


Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu Ala Arg Phe 
    50                  55                  60                  


Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg Val Cys Asn 
65                  70                  75                  80  


Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser Tyr Asn Phe 
                85                  90                  95      


Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile Ala Ser Pro 
        115                 120                 125             


Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys Ser Thr Pro 
    130                 135                 140                 


Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln Gly Gln Asp 
145                 150                 155                 160 


Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu Pro Thr Gly 
                165                 170                 175     


Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp Gln Asp His 
            180                 185                 190         


Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His Arg Ala Gln 
        195                 200                 205             


Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly Val Lys Ile 
    210                 215                 220                 


Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu Leu Val Thr 
225                 230                 235                 240 


Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser Ser Ile Lys 
                245                 250                 255     


Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly Val Leu His 
            260                 265                 270         


Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr Cys Gln Ala 
        275                 280                 285             


Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser 
    290                 295                 300     


<210>  18
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 1 Fragment (20-320) SAX (R97A)

<400>  18

Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val Lys Gly Ser 
1               5                   10                  15      


Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp Val Glu Val 
            20                  25                  30          


Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Gln Arg 
        35                  40                  45              


Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu Ala Arg Phe 
    50                  55                  60                  


Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg Val Cys Asn 
65                  70                  75                  80  


Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser Tyr Asn Phe 
                85                  90                  95      


Ala Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile Ala Ser Pro 
        115                 120                 125             


Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys Ser Thr Pro 
    130                 135                 140                 


Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln Gly Gln Asp 
145                 150                 155                 160 


Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu Pro Thr Gly 
                165                 170                 175     


Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp Gln Asp His 
            180                 185                 190         


Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His Arg Ala Gln 
        195                 200                 205             


Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly Val Lys Ile 
    210                 215                 220                 


Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu Leu Val Thr 
225                 230                 235                 240 


Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser Ser Ile Lys 
                245                 250                 255     


Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly Val Leu His 
            260                 265                 270         


Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr Cys Gln Ala 
        275                 280                 285             


Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser 
    290                 295                 300     


<210>  19
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 1 Fragment (20-320) / (G4S)2 / hIgG1 Fc N297G

<400>  19

Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val Lys Gly Ser 
1               5                   10                  15      


Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp Val Glu Val 
            20                  25                  30          


Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Gln Arg 
        35                  40                  45              


Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu Ala Arg Phe 
    50                  55                  60                  


Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg Val Cys Asn 
65                  70                  75                  80  


Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser Tyr Asn Phe 
                85                  90                  95      


Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile Ala Ser Pro 
        115                 120                 125             


Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys Ser Thr Pro 
    130                 135                 140                 


Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln Gly Gln Asp 
145                 150                 155                 160 


Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu Pro Thr Gly 
                165                 170                 175     


Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp Gln Asp His 
            180                 185                 190         


Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His Arg Ala Gln 
        195                 200                 205             


Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly Val Lys Ile 
    210                 215                 220                 


Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu Leu Val Thr 
225                 230                 235                 240 


Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser Ser Ile Lys 
                245                 250                 255     


Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly Val Leu His 
            260                 265                 270         


Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr Cys Gln Ala 
        275                 280                 285             


Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        435                 440                 445             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  20
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 1 Fragment (20-320) / (G4S)2 / hIgG1 Fc N297G

<400>  20
tcttggggcg ttagcagccc tcaggatgtg cagggcgtga agggaagctg tctgctgatc       60

ccctgcatct tcagcttccc cgccgatgtg gaagtgcccg atggaatcac agccatctgg      120

tactacgact acagcggcca gagacaggtg gtgtcccata gcgccgatcc taagctggtg      180

gaagcccggt ttagaggccg gaccgagttc atgggaaacc ccgagcacag agtgtgcaac      240

ctgctgctga aggacctgca gcctgaggat agcggcagct acaacttcag attcgagatc      300

agcgaagtga accgttggag cgacgtgaag ggcaccctgg tcacagtgac cgaggaaccc      360

agagtgccca caatcgcctc tccagtggaa ctgctggaag gcaccgaggt ggacttcaac      420

tgcagcaccc cttacgtgtg cctgcaagag caagttcggc tgcagtggca gggccaagat      480

cctgccagaa gcgtgacctt caacagccag aagttcgagc ctacaggcgt gggccacctg      540

gaaacactgc atatggccat gagctggcag gaccacggca gaatcctgag atgccagctg      600

agcgtggcca accacagagc ccagtctgag atccatctgc aagtgaagta cgcccctaaa      660

ggcgtgaaga ttctgctgag ccccagcggc agaaacatcc tgcctggcga actcgtgacc      720

ctgacctgcc aagtgaacag cagctaccct gccgtgtcca gcatcaagtg gctgaaagac      780

ggcgtgcggc tgcagacaaa aaccggcgtt ctgcatctgc ctcaggccgc ttggagtgac      840

gctggcgtgt acacttgtca ggccgagaat ggcgtgggca gcctggtgtc tcctcctatc      900

tctggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc      960

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta cggtagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1320

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1614


<210>  21
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 1 Fragment (20-320) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  21

Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val Lys Gly Ser 
1               5                   10                  15      


Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp Val Glu Val 
            20                  25                  30          


Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser Gly Gln Arg 
        35                  40                  45              


Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu Ala Arg Phe 
    50                  55                  60                  


Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg Val Cys Asn 
65                  70                  75                  80  


Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser Tyr Asn Phe 
                85                  90                  95      


Ala Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val Lys Gly Thr 
            100                 105                 110         


Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile Ala Ser Pro 
        115                 120                 125             


Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys Ser Thr Pro 
    130                 135                 140                 


Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln Gly Gln Asp 
145                 150                 155                 160 


Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu Pro Thr Gly 
                165                 170                 175     


Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp Gln Asp His 
            180                 185                 190         


Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His Arg Ala Gln 
        195                 200                 205             


Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly Val Lys Ile 
    210                 215                 220                 


Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu Leu Val Thr 
225                 230                 235                 240 


Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser Ser Ile Lys 
                245                 250                 255     


Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly Val Leu His 
            260                 265                 270         


Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr Cys Gln Ala 
        275                 280                 285             


Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
305                 310                 315                 320 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        355                 360                 365             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 


Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        435                 440                 445             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            500                 505                 510         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535             


<210>  22
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 1 Fragment (20-320) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  22
tcttggggcg ttagcagccc tcaggatgtg cagggcgtga agggaagctg tctgctgatc       60

ccctgcatct tcagcttccc cgccgatgtg gaagtgcccg atggaatcac agccatctgg      120

tactacgact acagcggcca gagacaggtg gtgtcccata gcgccgatcc taagctggtg      180

gaagcccggt ttagaggccg gaccgagttc atgggaaacc ccgagcacag agtgtgcaac      240

ctgctgctga aggacctgca gcctgaggat agcggcagct acaacttcgc cttcgagatc      300

agcgaagtga accgttggag cgacgtgaag ggcaccctgg tcacagtgac cgaggaaccc      360

agagtgccca caatcgcctc tccagtggaa ctgctggaag gcaccgaggt ggacttcaac      420

tgcagcaccc cttacgtgtg cctgcaagag caagttcggc tgcagtggca gggccaagat      480

cctgccagaa gcgtgacctt caacagccag aagttcgagc ctacaggcgt gggccacctg      540

gaaacactgc atatggccat gagctggcag gaccacggca gaatcctgag atgccagctg      600

agcgtggcca accacagagc ccagtctgag atccatctgc aagtgaagta cgcccctaaa      660

ggcgtgaaga ttctgctgag ccccagcggc agaaacatcc tgcctggcga actcgtgacc      720

ctgacctgcc aagtgaacag cagctaccct gccgtgtcca gcatcaagtg gctgaaagac      780

ggcgtgcggc tgcagacaaa aaccggcgtt ctgcatctgc ctcaggccgc ttggagtgac      840

gctggcgtgt acacttgtca ggccgagaat ggcgtgggca gcctggtgtc tcctcctatc      900

tctggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc      960

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1020

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1080

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1140

aagccgcggg aggagcagta cggtagcacg taccgtgtgg tcagcgtcct caccgtcctg     1200

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1260

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1320

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1380

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1440

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1500

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1560

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1614


<210>  23
<211>  847
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(847)
<223>  Siglec 2 FL

<400>  23

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  24
<211>  2544
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2544)
<223>  Siglec 2 FL

<400>  24
atgcatctcc tcggcccctg gctcctgctc ctggttctag aatacttggc tttctctgac       60

tcaagtaaat gggtttttga gcaccctgaa accctctacg cctgggaggg ggcctgcgtc      120

tggatcccct gcacctacag agccctagat ggtgacctgg aaagcttcat cctgttccac      180

aatcctgagt ataacaagaa cacctcgaag tttgatggga caagactcta tgaaagcaca      240

aaggatggga aggttccttc tgagcagaaa agggtgcaat tcctgggaga caagaataag      300

aactgcacac tgagtatcca cccggtgcac ctcaatgaca gtggtcagct ggggctgagg      360

atggagtcca agactgagaa atggatggaa cgaatacacc tcaatgtctc tgaaaggcct      420

tttccacctc atatccagct ccctccagaa attcaagagt cccaggaagt cactctgacc      480

tgcttgctga atttctcctg ctatgggtat ccgatccaat tgcagtggct cctagagggg      540

gttccaatga ggcaggctgc tgtcacctcg acctccttga ccatcaagtc tgtcttcacc      600

cggagcgagc tcaagttctc cccacagtgg agtcaccatg ggaagattgt gacctgccag      660

cttcaggatg cagatgggaa gttcctctcc aatgacacgg tgcagctgaa cgtgaagcac      720

accccgaagt tggagatcaa ggtcactccc agtgatgcca tagtgaggga gggggactct      780

gtgaccatga cctgcgaggt cagcagcagc aacccggagt acacgacggt atcctggctc      840

aaggatggga cctcgctgaa gaagcagaat acattcacgc taaacctgcg cgaagtgacc      900

aaggaccaga gtgggaagta ctgctgtcag gtctccaatg acgtgggccc gggaaggtcg      960

gaagaagtgt tcctgcaagt gcagtatgcc ccggaacctt ccacggttca gatcctccac     1020

tcaccggctg tggagggaag tcaagtcgag tttctttgca tgtcactggc caatcctctt     1080

ccaacaaatt acacgtggta ccacaatggg aaagaaatgc agggaaggac agaggagaaa     1140

gtccacatcc caaagatcct cccctggcac gctgggactt attcctgtgt ggcagaaaac     1200

attcttggta ctggacagag gggcccggga gctgagctgg atgtccagta tcctcccaag     1260

aaggtgacca cagtgattca aaaccccatg ccgattcgag aaggagacac agtgaccctt     1320

tcctgtaact acaattccag taaccccagt gttacccggt atgaatggaa accccatggc     1380

gcctgggagg agccatcgct tggggtgctg aagatccaaa acgttggctg ggacaacaca     1440

accatcgcct gcgcagcttg taatagttgg tgctcgtggg cctcccctgt cgccctgaat     1500

gtccagtatg ccccccgaga cgtgagggtc cggaaaatca agcccctttc cgagattcac     1560

tctggaaact cggtcagcct ccaatgtgac ttctcaagca gccaccccaa agaagtccag     1620

ttcttctggg agaaaaatgg caggcttctg gggaaagaaa gccagctgaa ttttgactcc     1680

atctccccag aagatgctgg gagttacagc tgctgggtga acaactccat aggacagaca     1740

gcgtccaagg cctggacact tgaagtgctg tatgcaccca ggaggctgcg tgtgtccatg     1800

agcccggggg accaagtgat ggaggggaag agtgcaaccc tgacctgtga gagcgacgcc     1860

aaccctcccg tctcccacta cacctggttt gactggaata accaaagcct cccctaccac     1920

agccagaagc tgagattgga gccggtgaag gtccagcact cgggtgccta ctggtgccag     1980

gggaccaaca gtgtgggcaa gggccgttcg cctctcagca ccctcaccgt ctactatagc     2040

ccggagacca tcggcaggcg agtggctgtg ggactcgggt cctgcctcgc catcctcatc     2100

ctggcaatct gtgggctcaa gctccagcga cgttggaaga ggacacagag ccagcagggg     2160

cttcaggaga attccagcgg ccagagcttc tttgtgagga ataaaaaggt tagaagggcc     2220

cccctctctg aaggccccca ctccctggga tgctacaatc caatgatgga agatggcatt     2280

agctacacca ccctgcgctt tcccgagatg aacataccac gaactggaga tgcagagtcc     2340

tcagagatgc agagacctcc cccggactgc gatgacacgg tcacttattc agcattgcac     2400

aagcgccaag tgggcgacta tgagaacgtc attccagatt ttccagaaga tgaggggatt     2460

cattactcag agctgatcca gtttggggtc ggggagcggc ctcaggcaca agaaaatgtg     2520

gactatgtga tcctcaaaca ttga                                            2544


<210>  25
<211>  364
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(364)
<223>  Siglec 3 FL

<400>  25

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  26
<211>  1466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1466)
<223>  Siglec 3 FL

<400>  26
tctgctcaca caggaagccc tggaagctgc ttcctcagac atgccgctgc tgctactgct       60

gcccctgctg tgggcagggg ccctggctat ggatccaaat ttctggctgc aagtgcagga      120

gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc tgcactttct tccatcccat      180

accctactac gacaagaact ccccagttca tggttactgg ttccgggaag gagccattat      240

atccagggac tctccagtgg ccacaaacaa gctagatcaa gaagtacagg aggagactca      300

gggcagattc cgcctccttg gggatcccag taggaacaac tgctccctga gcatcgtaga      360

cgccaggagg agggataatg gttcatactt ctttcggatg gagagaggaa gtaccaaata      420

cagttacaaa tctccccagc tctctgtgca tgtgacagac ttgacccaca ggcccaaaat      480

cctcatccct ggcactctag aacccggcca ctccaaaaac ctgacctgct ctgtgtcctg      540

ggcctgtgag cagggaacac ccccgatctt ctcctggttg tcagctgccc ccacctccct      600

gggccccagg actactcact cctcggtgct cataatcacc ccacggcccc aggaccacgg      660

caccaacctg acctgtcagg tgaagttcgc tggagctggt gtgactacgg agagaaccat      720

ccagctcaac gtcacctatg ttccacagaa cccaacaact ggtatctttc caggagatgg      780

ctcagggaaa caagagacca gagcaggagt ggttcatggg gccattggag gagctggtgt      840

tacagccctg ctcgctcttt gtctctgcct catcttcttc atagtgaaga cccacaggag      900

gaaagcagcc aggacagcag tgggcaggaa tgacacccac cctaccacag ggtcagcctc      960

cccgaaacac cagaagaagt ccaagttaca tggccccact gaaacctcaa gctgttcagg     1020

tgccgcccct actgtggaga tggatgagga gctgcattat gcttccctca actttcatgg     1080

gatgaatcct tccaaggaca cctccaccga atactcagag gtcaggaccc agtgaggaac     1140

ccacaagagc atcaggctca gctagaagat ccacatcctc tacaggtcgg ggaccaaagg     1200

ctgattcttg gagatttaac accccacagg caatgggttt atagacatta tgtgagtttc     1260

ctgctatatt aacatcatct tagactttgc aagcagagag tcgtggaatc aaatctgtgc     1320

tctttcattt gctaagtgta tgatgtcaca caagctcctt aaccttccat gtctccattt     1380

tcttctctgt gaagtaggta taagaagtcc tatctcatag ggatgctgtg agcattaaat     1440

aaaggtacac atggaaaaca ccagtc                                          1466


<210>  27
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(117)
<223>  Siglec 3 V-Set (23-139)

<400>  27

Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu 
1               5                   10                  15      


Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser 
            20                  25                  30          


Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp 
        35                  40                  45              


Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr 
    50                  55                  60                  


Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser 
65                  70                  75                  80  


Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe 
                85                  90                  95      


Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu 
            100                 105                 110         


Ser Val His Val Thr 
        115         


<210>  28
<211>  205
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(205)
<223>  Siglec 3 V-Set Domain + 1 C2-Set Domain (23-227)

<400>  28

Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu 
1               5                   10                  15      


Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser 
            20                  25                  30          


Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp 
        35                  40                  45              


Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr 
    50                  55                  60                  


Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser 
65                  70                  75                  80  


Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe 
                85                  90                  95      


Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu 
            100                 105                 110         


Ser Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro 
        115                 120                 125             


Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser 
    130                 135                 140                 


Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala 
145                 150                 155                 160 


Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile 
                165                 170                 175     


Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val 
            180                 185                 190         


Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile 
        195                 200                 205 


<210>  29
<211>  242
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(242)
<223>  Siglec 3 Fragment (18-259)

<400>  29

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  30
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) SAX

<400>  30

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Lys Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  31
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) SAX / AS / hIgG1 Fc N297G

<400>  31

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Lys Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  32
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) SAX / AS / hIgG1 Fc N297G

<400>  32
gatcccaatt tctggctgca agtgcaagag tccgtgaccg tgcaagaggg cctgtgtgtg       60

ctggtgccct gcaccttctt tcaccccatt ccttactacg acaagaacag ccctgtgcac      120

ggctactggt ttagagaggg cgccatcatc agcagagata gccctgtggc caccaacaag      180

ctggaccaag aggtgcaaga agagacacag ggcagattca gactgctggg cgaccccagc      240

agaaacaact gcagcctgtc tatcgtggac gccaggcgga gagacaacgg cagctacttc      300

ttcaagatgg aacggggcag caccaagtac agctacaaga gccctcagct gtccgtgcac      360

gtgaccgacc tgacacacag acccaagatt ctgatccccg gcacactgga acctggccac      420

agcaagaatc tgacctgctc cgtgtcctgg gcctgcgaac agggaacccc tcctatcttt      480

agctggctga gcgccgctcc tacatctctg ggccctagaa caacacacag cagcgtgctg      540

atcatcaccc ctagacctca ggaccacggc accaacctga cctgccaagt gaaatttgct      600

ggcgctggcg tgaccaccga gagaaccatc cagctgaacg tgacctacgt gccacagaac      660

cctaccaccg gcatctttcc aggcgacggc tctggcaagc aagaaacaag agctggcgtg      720

gtgcacgcta gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaa                                  1413


<210>  33
<211>  626
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(626)
<223>  Siglec 4 FL

<400>  33

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                565                 570                 575     


Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
            580                 585                 590         


Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
        595                 600                 605             


Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
    610                 615                 620                 


Val Lys 
625     


<210>  34
<211>  1881
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1881)
<223>  Siglec 4 FL

<400>  34
atgatattcc tcacggcact gcctctgttc tggattatga tttcagcctc ccgagggggt       60

cactggggtg cctggatgcc ctcgtccatc tcggccttcg aaggcacgtg cgtctccatc      120

ccctgccgct ttgacttccc ggatgagctg cggcccgctg tggtgcatgg tgtctggtac      180

ttcaatagcc cctaccccaa gaactacccc ccggtggtct tcaagtcgcg cacccaagta      240

gtccacgaga gcttccaggg ccgcagccgc ctcctggggg acctgggcct gcgaaactgc      300

accctcctgc tcagcaacgt cagccccgag ctgggcggga agtactactt ccgtggggac      360

ctgggcggct acaaccagta caccttctca gagcacagcg tcctggatat cgtcaacacc      420

cccaacatcg tggtgccccc agaggtggtg gcaggcacgg aggtggaggt cagctgcatg      480

gtgccggaca actgcccaga gctgcgccct gagctgagct ggctgggcca cgaggggctg      540

ggggagcccg ctgtgctggg ccggctgcgg gaggacgagg gcacctgggt gcaggtgtca      600

ctgctgcact tcgtgcccac gagggaggcc aacggccaca ggctgggctg ccaggcctcc      660

ttccccaaca ccaccctgca gttcgagggc tacgccagca tggacgtcaa gtaccccccg      720

gtgattgtgg agatgaactc ctcggtggag gccatcgagg gctcccacgt gagcctgctc      780

tgtggggctg acagcaaccc cccgccgctg ctgacctgga tgcgggacgg gacagtcctc      840

cgggaggcgg tggccgagag cctgctcctg gagctggagg aggtgacccc cgccgaagac      900

ggcgtctatg cctgcctggc cgagaatgcc tatggccagg acaaccgcac cgtggggctc      960

agtgtcatgt atgcaccctg gaagccaaca gtgaacggga caatggtggc cgtagagggg     1020

gagacggtct ctatcttgtg ctccacacag agcaacccgg accctattct caccatcttc     1080

aaggagaagc agatcctgtc cacggtcatc tacgagagcg agctgcagct ggagctgccg     1140

gccgtgtcac ccgaggatga tggagagtac tggtgtgtgg ctgagaacca gtatggccag     1200

agggccaccg ccttcaacct gtctgtggag ttcgcccctg tgctcctcct ggagtcccac     1260

tgcgcggcag cccgagacac ggtgcagtgc ctgtgcgtgg tgaagtccaa cccggagccg     1320

tccgtggcct ttgagctgcc atcgcgcaat gtgaccgtga acgagagcga gcgggagttc     1380

gtgtactcgg agcgcagcgg cctcgtgctc accagcatcc tcacgctgcg ggggcaggcc     1440

caggccccgc cccgcgtcat ctgcaccgcg aggaacctct atggcgccaa gagcctggag     1500

ctgcccttcc agggagccca tcgactgatg tgggccaaga tcgggcctgt gggcgccgtg     1560

gtcgcctttg ccatcctgat tgccatcgtc tgctacatta cccagacacg caggaaaaag     1620

aacgtgacag agagccccag cttctcggca ggggacaacc ctcccgtcct gttcagcagc     1680

gacttccgca tctctggggc accagagaag tacgagagcg agaggcgcct gggatctgag     1740

aggaggctgc tgggccttcg gggtgagccc ccagagctgg acctgagcta ttctcactcg     1800

gacctgggga aacggcccac caaggacagc tacacgctga cggaggagct agctgagtat     1860

gctgaaatcc gggtcaagtg a                                               1881


<210>  35
<211>  497
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(497)
<223>  Siglec 4 Fragment (20-516)

<400>  35

Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly 
1               5                   10                  15      


Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg 
            20                  25                  30          


Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys 
        35                  40                  45              


Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val Val His Glu 
    50                  55                  60                  


Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr 
                85                  90                  95      


Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu 
            100                 105                 110         


His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val Val Pro Pro 
        115                 120                 125             


Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met Val Pro Asp 
    130                 135                 140                 


Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly His Glu Gly 
145                 150                 155                 160 


Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr 
                165                 170                 175     


Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg Glu Ala Asn 
            180                 185                 190         


Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln 
        195                 200                 205             


Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro Val Ile Val 
    210                 215                 220                 


Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His Val Ser Leu 
225                 230                 235                 240 


Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr Trp Met Arg 
                245                 250                 255     


Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu Leu Leu Glu 
            260                 265                 270         


Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala 
        275                 280                 285             


Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu Ser Val Met 
    290                 295                 300                 


Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val Ala Val Glu 
305                 310                 315                 320 


Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro 
                325                 330                 335     


Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr 
            340                 345                 350         


Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro Glu Asp Asp 
        355                 360                 365             


Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr 
    370                 375                 380                 


Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu Leu Glu Ser 
385                 390                 395                 400 


His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys Val Val Lys 
                405                 410                 415     


Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser Arg Asn Val 
            420                 425                 430         


Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly 
        435                 440                 445             


Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro 
    450                 455                 460                 


Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu 
465                 470                 475                 480 


Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala Lys Ile Gly 
                485                 490                 495     


Pro 
    


<210>  36
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 4 Fragment (20-516) SAX

<400>  36

Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly 
1               5                   10                  15      


Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg 
            20                  25                  30          


Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys 
        35                  40                  45              


Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val Val His Glu 
    50                  55                  60                  


Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr 
                85                  90                  95      


Tyr Phe Ala Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu 
            100                 105                 110         


His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val Val Pro Pro 
        115                 120                 125             


Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met Val Pro Asp 
    130                 135                 140                 


Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly His Glu Gly 
145                 150                 155                 160 


Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr 
                165                 170                 175     


Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg Glu Ala Asn 
            180                 185                 190         


Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln 
        195                 200                 205             


Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro Val Ile Val 
    210                 215                 220                 


Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His Val Ser Leu 
225                 230                 235                 240 


Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr Trp Met Arg 
                245                 250                 255     


Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu Leu Leu Glu 
            260                 265                 270         


Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala 
        275                 280                 285             


Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu Ser Val Met 
    290                 295                 300                 


Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val Ala Val Glu 
305                 310                 315                 320 


Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro 
                325                 330                 335     


Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr 
            340                 345                 350         


Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro Glu Asp Asp 
        355                 360                 365             


Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr 
    370                 375                 380                 


Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu Leu Glu Ser 
385                 390                 395                 400 


His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys Val Val Lys 
                405                 410                 415     


Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser Arg Asn Val 
            420                 425                 430         


Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly 
        435                 440                 445             


Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro 
    450                 455                 460                 


Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu 
465                 470                 475                 480 


Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala Lys Ile Gly 
                485                 490                 495     


Pro 
    


<210>  37
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 4 Fragment (20-516) / (G4S)2 / hIgG1 Fc N297G

<400>  37

Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly 
1               5                   10                  15      


Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg 
            20                  25                  30          


Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys 
        35                  40                  45              


Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val Val His Glu 
    50                  55                  60                  


Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr 
                85                  90                  95      


Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu 
            100                 105                 110         


His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val Val Pro Pro 
        115                 120                 125             


Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met Val Pro Asp 
    130                 135                 140                 


Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly His Glu Gly 
145                 150                 155                 160 


Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr 
                165                 170                 175     


Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg Glu Ala Asn 
            180                 185                 190         


Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln 
        195                 200                 205             


Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro Val Ile Val 
    210                 215                 220                 


Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His Val Ser Leu 
225                 230                 235                 240 


Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr Trp Met Arg 
                245                 250                 255     


Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu Leu Leu Glu 
            260                 265                 270         


Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala 
        275                 280                 285             


Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu Ser Val Met 
    290                 295                 300                 


Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val Ala Val Glu 
305                 310                 315                 320 


Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro 
                325                 330                 335     


Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr 
            340                 345                 350         


Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro Glu Asp Asp 
        355                 360                 365             


Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr 
    370                 375                 380                 


Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu Leu Glu Ser 
385                 390                 395                 400 


His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys Val Val Lys 
                405                 410                 415     


Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser Arg Asn Val 
            420                 425                 430         


Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly 
        435                 440                 445             


Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro 
    450                 455                 460                 


Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu 
465                 470                 475                 480 


Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala Lys Ile Gly 
                485                 490                 495     


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
            500                 505                 510         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        515                 520                 525             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    530                 535                 540                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
545                 550                 555                 560 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                565                 570                 575     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            580                 585                 590         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        595                 600                 605             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    610                 615                 620                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
625                 630                 635                 640 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                645                 650                 655     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            660                 665                 670         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        675                 680                 685             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    690                 695                 700                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
705                 710                 715                 720 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730                 


<210>  38
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 4 Fragment (20-516) / (G4S)2 / hIgG1 Fc N297G

<400>  38
ggacattggg gagcctggat gcctagcagc atcagcgcct ttgagggaac ctgtgtgtca       60

atcccctgca gattcgactt ccccgacgaa ctgaggcctg ctgtggttca cggcgtgtgg      120

tacttcaaca gcccctatcc taagaactac cctcctgtgg tgttcaagag cagaacccag      180

gtggtgcacg agagcttcca gggcagatct agactgctgg gcgatctggg cctgagaaac      240

tgtacactgc tgctgagcaa cgtgtcccct gaactcggcg gcaagtacta cttcagaggc      300

gatctcggcg gctacaacca gtacaccttt agcgagcaca gcgtgctgga catcgtgaac      360

acccctaaca tcgtggtgcc tccagaagtg gtggccggca cagaggtgga agtgtcctgt      420

atggtgcccg acaactgccc tgagctgagg ccagaactgt cttggctggg acacgaagga      480

ctgggagaac ctgctgttct gggcagactg agagaggacg aaggcacctg ggtgcaagtg      540

tccctgctgc actttgtgcc taccagagag gccaacggcc acagactggg ttgtcaggcc      600

agctttccca acaccacact gcagtttgag ggctacgcca gcatggacgt gaagtaccct      660

ccagtgatcg tggaaatgaa cagcagcgtg gaagccatcg agggctctca tgtgtctctg      720

ctgtgtggcg ccgacagcaa tcctcctcct ctgctgacct ggatgagaga tggcaccgtg      780

ctgagagaag ccgtggccga atctctgctg ctggaactgg aagaagtgac ccctgccgag      840

gatggcgtgt acgcttgtct ggccgagaat gcctacggcc aggacaatag aaccgtgggc      900

ctgtccgtga tgtacgcccc ttggaagcct accgtgaacg gcacaatggt ggccgtggaa      960

ggcgagacag tgtccatcct gtgtagcacc cagagcaacc ccgatcctat cctgaccatc     1020

ttcaaagaga agcagatcct gagcaccgtg atctacgaga gcgaactgca gctcgaactg     1080

cccgctgtgt ccccagagga tgatggcgaa tattggtgcg tggcagagaa ccagtacggc     1140

cagagagcca ccgccttcaa cctgagcgtg gaatttgctc ccgtgctgct gctcgagagc     1200

cattgtgctg ccgccagaga taccgtgcag tgcctgtgtg tggtcaagtc taaccccgag     1260

cctagcgtgg cctttgagct gcccagcaga aacgtgaccg tgaatgagag cgagcgcgag     1320

ttcgtgtaca gcgagagatc tggactggtg ctgaccagca tcctgacact gagaggacag     1380

gctcaggccc ctcctagagt gatctgcacc gccagaaatc tgtacggcgc caagagcctg     1440

gaactgccat ttcagggcgc ccacagactc atgtgggcca agattggacc tggcggaggt     1500

ggaagtggcg gaggcggatc cgacaaaact cacacatgcc caccgtgccc agcacctgaa     1560

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1620

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1680

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1740

gagcagtacg gtagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1800

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1860

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtctacac cctgccccca     1920

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1980

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     2040

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     2100

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2160

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        2202


<210>  39
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 4 Fragment (20-516) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  39

Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly 
1               5                   10                  15      


Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg 
            20                  25                  30          


Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys 
        35                  40                  45              


Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val Val His Glu 
    50                  55                  60                  


Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn 
65                  70                  75                  80  


Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr 
                85                  90                  95      


Tyr Phe Ala Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu 
            100                 105                 110         


His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val Val Pro Pro 
        115                 120                 125             


Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met Val Pro Asp 
    130                 135                 140                 


Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly His Glu Gly 
145                 150                 155                 160 


Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr 
                165                 170                 175     


Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg Glu Ala Asn 
            180                 185                 190         


Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln 
        195                 200                 205             


Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro Val Ile Val 
    210                 215                 220                 


Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His Val Ser Leu 
225                 230                 235                 240 


Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr Trp Met Arg 
                245                 250                 255     


Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu Leu Leu Glu 
            260                 265                 270         


Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala 
        275                 280                 285             


Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu Ser Val Met 
    290                 295                 300                 


Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val Ala Val Glu 
305                 310                 315                 320 


Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro 
                325                 330                 335     


Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr 
            340                 345                 350         


Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro Glu Asp Asp 
        355                 360                 365             


Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr 
    370                 375                 380                 


Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu Leu Glu Ser 
385                 390                 395                 400 


His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys Val Val Lys 
                405                 410                 415     


Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser Arg Asn Val 
            420                 425                 430         


Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly 
        435                 440                 445             


Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro 
    450                 455                 460                 


Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu 
465                 470                 475                 480 


Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala Lys Ile Gly 
                485                 490                 495     


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
            500                 505                 510         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        515                 520                 525             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    530                 535                 540                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
545                 550                 555                 560 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                565                 570                 575     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            580                 585                 590         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        595                 600                 605             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    610                 615                 620                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
625                 630                 635                 640 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                645                 650                 655     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            660                 665                 670         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        675                 680                 685             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    690                 695                 700                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
705                 710                 715                 720 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730                 


<210>  40
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 4 Fragment (20-516) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  40
ggacattggg gagcctggat gcctagcagc atcagcgcct ttgagggaac ctgtgtgtca       60

atcccctgca gattcgactt ccccgacgaa ctgaggcctg ctgtggttca cggcgtgtgg      120

tacttcaaca gcccctatcc taagaactac cctcctgtgg tgttcaagag cagaacccag      180

gtggtgcacg agagcttcca gggcagatct agactgctgg gcgatctggg cctgagaaac      240

tgtacactgc tgctgagcaa cgtgtcccct gaactcggcg gcaagtacta cttcgccggc      300

gatctcggcg gctacaacca gtacaccttt agcgagcaca gcgtgctgga catcgtgaac      360

acccctaaca tcgtggtgcc tccagaagtg gtggccggca cagaggtgga agtgtcctgt      420

atggtgcccg acaactgccc tgagctgagg ccagaactgt cttggctggg acacgaagga      480

ctgggagaac ctgctgttct gggcagactg agagaggacg aaggcacctg ggtgcaagtg      540

tccctgctgc actttgtgcc taccagagag gccaacggcc acagactggg ttgtcaggcc      600

agctttccca acaccacact gcagtttgag ggctacgcca gcatggacgt gaagtaccct      660

ccagtgatcg tggaaatgaa cagcagcgtg gaagccatcg agggctctca tgtgtctctg      720

ctgtgtggcg ccgacagcaa tcctcctcct ctgctgacct ggatgagaga tggcaccgtg      780

ctgagagaag ccgtggccga atctctgctg ctggaactgg aagaagtgac ccctgccgag      840

gatggcgtgt acgcttgtct ggccgagaat gcctacggcc aggacaatag aaccgtgggc      900

ctgtccgtga tgtacgcccc ttggaagcct accgtgaacg gcacaatggt ggccgtggaa      960

ggcgagacag tgtccatcct gtgtagcacc cagagcaacc ccgatcctat cctgaccatc     1020

ttcaaagaga agcagatcct gagcaccgtg atctacgaga gcgaactgca gctcgaactg     1080

cccgctgtgt ccccagagga tgatggcgaa tattggtgcg tggcagagaa ccagtacggc     1140

cagagagcca ccgccttcaa cctgagcgtg gaatttgctc ccgtgctgct gctcgagagc     1200

cattgtgctg ccgccagaga taccgtgcag tgcctgtgtg tggtcaagtc taaccccgag     1260

cctagcgtgg cctttgagct gcccagcaga aacgtgaccg tgaatgagag cgagcgcgag     1320

ttcgtgtaca gcgagagatc tggactggtg ctgaccagca tcctgacact gagaggacag     1380

gctcaggccc ctcctagagt gatctgcacc gccagaaatc tgtacggcgc caagagcctg     1440

gaactgccat ttcagggcgc ccacagactc atgtgggcca agattggacc tggcggaggt     1500

ggaagtggcg gaggcggatc cgacaaaact cacacatgcc caccgtgccc agcacctgaa     1560

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1620

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1680

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1740

gagcagtacg gtagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1800

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1860

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtctacac cctgccccca     1920

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1980

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     2040

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     2100

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     2160

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        2202


<210>  41
<211>  551
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(551)
<223>  Siglec 5 FL

<400>  41

Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln 
1               5                   10                  15      


Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
        35                  40                  45              


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
    50                  55                  60                  


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
65                  70                  75                  80  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
                85                  90                  95      


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
            100                 105                 110         


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
        115                 120                 125             


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
    130                 135                 140                 


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
145                 150                 155                 160 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
                165                 170                 175     


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
            180                 185                 190         


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
        195                 200                 205             


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
    210                 215                 220                 


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
225                 230                 235                 240 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
                245                 250                 255     


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
            260                 265                 270         


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
        275                 280                 285             


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
305                 310                 315                 320 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
                325                 330                 335     


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
            340                 345                 350         


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
        355                 360                 365             


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
    370                 375                 380                 


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
385                 390                 395                 400 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
                405                 410                 415     


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
            420                 425                 430         


Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly Ala Gly Val Met Ala 
        435                 440                 445             


Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe Leu Ile Val Lys Ala 
    450                 455                 460                 


Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp 
465                 470                 475                 480 


Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro 
                485                 490                 495     


Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu 
            500                 505                 510         


Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met 
        515                 520                 525             


Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr 
    530                 535                 540                 


Ser Glu Ile Lys Thr Ser Lys 
545                 550     


<210>  42
<211>  2523
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2523)
<223>  Siglec 5 FL

<400>  42
gtgcgcgtcc acagctctca ctcaccctcc ggcttcctgt cggggctttc tcagccccac       60

cccacgtttg gacatttgga gcatttcctt ccctgacagc cggacctggg actgggctgg      120

ggccctggcg gatggagaca tgctgcccct gctgctgctg cccctgctgt ggggggggtc      180

cctgcaggag aagccagtgt acgagctgca agtgcagaag tcggtgacgg tgcaggaggg      240

cctgtgcgtc cttgtgccct gctccttctc ttacccctgg agatcctggt attcctctcc      300

cccactctac gtctactggt tccgggacgg ggagatccca tactacgctg aggttgtggc      360

cacaaacaac ccagacagaa gagtgaagcc agagacccag ggccgattcc gcctccttgg      420

ggatgtccag aagaagaact gctccctgag catcggagat gccagaatgg aggacacggg      480

aagctatttc ttccgcgtgg agagaggaag ggatgtaaaa tatagctacc aacagaataa      540

gctgaacttg gaggtgacag ccctgataga gaaacccgac atccactttc tggagcctct      600

ggagtccggc cgccccacaa ggctgagctg cagccttcca ggatcctgtg aagcgggacc      660

acctctcaca ttctcctgga cggggaatgc cctcagcccc ctggaccccg agaccacccg      720

ctcctcggag ctcaccctca cccccaggcc cgaggaccat ggcaccaacc tcacctgtca      780

gatgaaacgc caaggagctc aggtgaccac ggagagaact gtccagctca atgtctccta      840

tgctccacag accatcacca tcttcaggaa cggcatagcc ctagagatcc tgcaaaacac      900

ctcatacctt ccggtcctgg agggccaggc tctgcggctg ctctgtgatg ctcccagcaa      960

cccccctgca cacctgagct ggttccaggg ctcccctgcc ctgaacgcca cccccatctc     1020

caataccggg atcttggagc ttcgtcgagt aaggtctgca gaagaaggag gcttcacctg     1080

ccgcgctcag cacccgctgg gcttcctgca aatttttctg aatctctcag tttactccct     1140

cccacagttg ctgggcccct cctgctcctg ggaggctgag ggtctgcact gcagatgctc     1200

ctttcgagcc cggccggccc cctccctgtg ctggcggctt gaggagaagc cgctggaggg     1260

gaacagcagc cagggctcat tcaaggtcaa ctccagctca gctgggccct gggccaacag     1320

ctccctgatc ctccacgggg ggctcagctc cgacctcaaa gtcagctgca aggcctggaa     1380

catctatggg tcccagagcg gctctgtcct gctgctgcaa gggagatcga acctcgggac     1440

aggagtggtt cctgcagccc ttggtggtgc tggtgtcatg gccctgctct gtatctgtct     1500

gtgcctcatc ttctttttaa tagtgaaagc ccgcaggaag caagcagctg ggagaccaga     1560

gaaaatggat gatgaagacc ccattatggg taccatcacc tcgggttcca ggaagaagcc     1620

ctggccagac agccccggag atcaagcatc tcctcctggg gatgcccctc ccttggaaga     1680

acaaaaggag ctccattatg cctcccttag tttttctgag atgaagtcga gggagcctaa     1740

ggaccaggag gccccaagca ccacggagta ctcggagatc aagacaagca agtgaggatt     1800

tgcccagagt tcagtcctgg ctggaggagc cacagcctgt ctgggggaaa ggacaagtca     1860

gggaccactt gctgaagcac gaagagccct tgtggcaatg ttaacattaa ctgatgttta     1920

agtgctccaa gcagatggaa ttagagaggt gggctcaaat ctaggccctg gcactgtcat     1980

caagcaattc actgcatccc tctgtgcctc agtttcccat tctgtaaatc agagatcatg     2040

catgctacct caaaggttgt tgtgaacatt aaagaaatca acacatggaa atcaaccaac     2100

atgggtcctg gaacagggcg ttgtgctcag tgctttctgg tctctcttcc ttgaatagaa     2160

aggtcctgct ggcaagttct ctcaaggctg gggatgacca ggcacaaaaa acagggcagc     2220

aatatgttgg tgtcactccc cttcccaaaa ctcttcgaag actccctagg aaagaccagc     2280

ccctcagcct ggcacttggt tcatgatgtg ggatcttata tccttgccag agtcatatct     2340

ttgcccactt ttacctgcaa tccttgcatc atattccttt ggctccagtc cttcatttat     2400

gagacccata ggaatccttc caacagccaa agagttgagt ctaactcttt cctgcccaaa     2460

cccattcacg gccccctggc cttagacaat atatcacaag catctcccct gacacataaa     2520

gtc                                                                   2523


<210>  43
<211>  453
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(453)
<223>  Siglec 6 FL

<400>  43

Met Gln Gly Ala Gln Glu Ala Ser Ala Ser Glu Met Leu Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala Gln Glu Arg Arg Phe Gln 
            20                  25                  30          


Leu Glu Gly Pro Glu Ser Leu Thr Val Gln Glu Gly Leu Cys Val Leu 
        35                  40                  45              


Val Pro Cys Arg Leu Pro Thr Thr Leu Pro Ala Ser Tyr Tyr Gly Tyr 
    50                  55                  60                  


Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val Pro Val Ala Thr Asn Asp 
65                  70                  75                  80  


Pro Asp Glu Glu Val Gln Glu Glu Thr Arg Gly Arg Phe His Leu Leu 
                85                  90                  95      


Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg 
            100                 105                 110         


Arg Arg Asp Asn Ala Ala Tyr Phe Phe Arg Leu Lys Ser Lys Trp Met 
        115                 120                 125             


Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser Val Arg Val Met Ala Leu 
    130                 135                 140                 


Thr His Arg Pro Asn Ile Ser Ile Pro Gly Thr Leu Glu Ser Gly His 
145                 150                 155                 160 


Pro Ser Asn Leu Thr Cys Ser Val Pro Trp Val Cys Glu Gln Gly Thr 
                165                 170                 175     


Pro Pro Ile Phe Ser Trp Met Ser Ala Ala Pro Thr Ser Leu Gly Pro 
            180                 185                 190         


Arg Thr Thr Gln Ser Ser Val Leu Thr Ile Thr Pro Arg Pro Gln Asp 
        195                 200                 205             


His Ser Thr Asn Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Gly Val 
    210                 215                 220                 


Thr Met Glu Arg Thr Ile Gln Leu Asn Val Ser Tyr Ala Pro Gln Lys 
225                 230                 235                 240 


Val Ala Ile Ser Ile Phe Gln Gly Asn Ser Ala Ala Phe Lys Ile Leu 
                245                 250                 255     


Gln Asn Thr Ser Ser Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu 
            260                 265                 270         


Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala His Leu Ser Trp Phe Gln 
        275                 280                 285             


Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile Ser Asn Thr Gly Val Leu 
    290                 295                 300                 


Glu Leu Pro Gln Val Gly Ser Ala Glu Glu Gly Asp Phe Thr Cys Arg 
305                 310                 315                 320 


Ala Gln His Pro Leu Gly Ser Leu Gln Ile Ser Leu Ser Leu Phe Val 
                325                 330                 335     


His Trp Lys Pro Glu Gly Arg Ala Gly Gly Val Leu Gly Ala Val Trp 
            340                 345                 350         


Gly Ala Ser Ile Thr Thr Leu Val Phe Leu Cys Val Cys Phe Ile Phe 
        355                 360                 365             


Arg Val Lys Thr Arg Arg Lys Lys Ala Ala Gln Pro Val Gln Asn Thr 
    370                 375                 380                 


Asp Asp Val Asn Pro Val Met Val Ser Gly Ser Arg Gly His Gln His 
385                 390                 395                 400 


Gln Phe Gln Thr Gly Ile Val Ser Asp His Pro Ala Glu Ala Gly Pro 
                405                 410                 415     


Ile Ser Glu Asp Glu Gln Glu Leu His Tyr Ala Val Leu His Phe His 
            420                 425                 430         


Lys Val Gln Pro Gln Glu Pro Lys Val Thr Asp Thr Glu Tyr Ser Glu 
        435                 440                 445             


Ile Lys Ile His Lys 
    450             


<210>  44
<211>  3815
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3815)
<223>  Siglec 6 FL

<400>  44
gcgggacaca gtctcttctc ctctgctctt ctttgggcag gtctctgggt ctcaaagttt       60

ccgtctgctc tgtgcagagg gagtggagct ccgagggctt gtggcttcgc agttcctctt      120

ctgtgaacag ccgagatcac gcgctcctcc ccagccaccc gttcctcccc gcagtccttc      180

ccctccactc ccttcccctt ctctgctcat gcagggagcc caggaagcct ccgcctcaga      240

gatgctaccg ctgctgctgc ccctgctgtg ggcaggggcc ctggctcagg agcggagatt      300

ccagctggag gggccagagt cactgacggt gcaggagggt ctgtgcgtcc tcgtaccctg      360

cagattgccc actacccttc cagcctcgta ctatggttat ggctactggt tcctggaagg      420

ggctgatgtt ccagtggcca caaacgaccc agacgaagaa gtgcaggagg agacccgggg      480

ccgattccac ctcctctggg atcccagaag gaagaactgc tccctgagca tcagagatgc      540

ccggaggagg gacaatgctg catacttctt tcggttgaag tccaaatgga tgaaatacgg      600

ttatacatct tccaagctct ctgtgcgtgt gatggccctg acccacaggc ccaacatctc      660

catcccaggg accctggagt ctggccatcc cagcaatctg acctgctctg tgccctgggt      720

ctgtgagcag gggacgcccc ccatcttctc ctggatgtca gctgccccca cctccctggg      780

ccccaggacc acccagtcct cggtgctcac aatcacccca cggccccagg accacagcac      840

caacctcacc tgtcaggtga cgttccctgg agccggtgtg accatggaga gaaccatcca      900

gctcaatgtc tcctccttca aaatcctgca aaacacctcg tccctccctg tcctggaggg      960

ccaggctctg cggctgctct gtgatgctga cggcaacccc cctgcacacc tgagctggtt     1020

ccagggcttc cccgccctga acgccacccc catctccaat accggggtcc tggagctgcc     1080

tcaagtaggg tctgcagaag aaggagattt cacctgccgt gctcagcatc ctctgggctc     1140

cctgcaaatc tctctgagtc tctttgtgca ttggaaacca gaaggcaggg ctggtggtgt     1200

cctgggagca gtctggggag ctagcatcac aaccctggtt ttcctctgtg tttgcttcat     1260

cttcagagtg aagactagaa ggaagaaagc agcccagcca gtgcaaaaca cggatgatgt     1320

gaaccccgtc atggtctcag gctccagggg tcatcagcac cagttccaga caggcatagt     1380

ttcagaccac cctgctgagg ctggccccat ctcagaagat gagcaggagc tccactacgc     1440

tgtcctacac ttccacaagg tgcaacctca ggaaccaaag gtcaccgaca ctgagtactc     1500

agaaatcaag atacacaagt gaggaattgt ccaaagccat aaccttgatt ggagagaaca     1560

tggtacctct cagtgtattg gttactaggg ctgccacagc aatgtaccac aaaccgagtg     1620

acataaacac agaactttat tttcgtatag tttcagatgt tagaggtctg agaacaaggt     1680

gttatcaggg ttggtccctt ctaaggcctc tcttgttggc ttgtagatgg ctgtctcctc     1740

cttgtgtctt cacatggtct ttcctctgag tgtgtttgtg tcctaatctt ctcttcttat     1800

aaagacacta gtcatattgg attagggcct ccccatgacc taatttaaat aaattaacta     1860

tttaaagacc ctccaaatac agtaaccttc tgagatattg agatttagga cttccaacat     1920

atgaatttta gaagggaaca atttagccca taacactgtg tccaattctt ttaaaattaa     1980

tgtttttgtt gtaaatggac tatataaata ccttcgtata tatggcagac cacaggactt     2040

ctgtccaaga gaactgagtt caactccatc tatgccagct attgagcaag tcgctttatg     2100

tccctgctct gtaaggcagg gaaataattt ccatctaacc agattattgt gaaaggtcaa     2160

agaaagcata cagctaacat acagctttgt tagctgtaaa acagctaaca aaggccctga     2220

cacaaaggtt ttcataaagt ctgtatattt ttgtaaatga atgccttgta tctggctttg     2280

gctagctttt tttttttttt tttttttctg agatggagtc ttgctgtatc tcccaggctg     2340

gagtgcagtg gtgcgatctt ggctcagtgc aagcttcgcc ccctgggttc acaccattct     2400

cctgcctcag cctcccaagt agctgggact acaggcaccc accaccacac ccggctaatt     2460

ttttgtattt ttagtagaga cggggtttca ccgtgttagc caggatggtc ttgatctcct     2520

gacctcgtga tctgccctcc tcggcctccc aaagtgctga gattacaggc atgagccacc     2580

gcacccggct ttgattagct gttttaacag acggtttctg ctggcaattt cttctaaggc     2640

tgaaaaggag taggcccaga ggccacagca ccaggtgtct gtgtcacccc ctgttcagaa     2700

ctcttcacga ctccccaaaa taaggtttcc atccatcatc tttctgctca aggctctcta     2760

catgatcttg tccatccaga tttccccaga tcaattcctc accagtcacc aataccccat     2820

gtccatttcc acagcttcct cttacaaatc ccagtctcca ctattccagt gaaattgaag     2880

aaagcattta atgaagacca actattaagg aaaattctta agagtagcca tgaaaaataa     2940

aaagatagat tacacttaaa agaccacagt tagcagtggc tcacgcctgt aatcccagca     3000

ctttgggagg ctgaggtggg tggatcactg gaggtcagga gttcgagact ggtctggcca     3060

acatggtgaa accccatctc tactaaaata caaaaattag ctcggtgtgg tggcacttgc     3120

ctgtaatccc aggtacttct gcaggttgaa gcaggagaat tgcttgaacc tgggaggtgg     3180

aggttgaagt gagctgagat tgcatcactg cactccagcc tgggcaacag agcgagactc     3240

caactcagaa aaagcaaaac aaaacaaaca aacaagcaaa aaaccacaat tagactgaca     3300

gctgactttt ttaggagcaa tattggaagg ctaaatgcaa tagaaagatg tctttgatgg     3360

cttaagagaa ataaatgttg ttttagaaag cctactcaat gaaaacacat tttaagactg     3420

aaagtgaaat atagatattt taaggaaaac caaaatatgt gagtgttaat aaagaaaaga     3480

tttctcaaat aaattctaaa acatataatt caggtattag gaaagtgatc ccagattaga     3540

tttttgagat ccaaaaaaaa tgaaaaccta ggaaagtagc aaatatgtga gcaaaatgaa     3600

acaaatactt gttgtaaaaa tgatggtttg tagaggggtc aaacatcaaa tgtaatattg     3660

aaataccaat attatatagc ccagaaacta taataacata aagttcagaa gagtgtaaat     3720

agaatttata ttacataaag tctttatatt tttccagaga aaattaaatg ttatgatgaa     3780

tgttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                3815


<210>  45
<211>  321
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Siglec 6 Fragment (27-347)

<400>  45

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Arg 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val 
    


<210>  46
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX

<400>  46

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Ala 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val 
    


<210>  47
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) / (G4S)2 / hIgG1 Fc N297G

<400>  47

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Arg 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  48
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) / (G4S)2 / hIgG1 Fc N297G

<400>  48
caagagcggc ggtttcagct ggaaggacct gagagcctga cagtgcaaga gggcctgtgt       60

gtgctggtgc cttgtagact gcctaccaca ctgcccgcca gctactacgg ctacggctat      120

tggtttctgg aaggcgccga tgtgcccgtg gccaccaatg atcctgacga ggaagtgcaa      180

gaagagacac ggggcagatt ccatctgctg tgggacccca gacggaagaa ctgcagcctg      240

agcatcagag atgccagaag gcgggataac gccgcctact tcttccggct gaagtccaag      300

tggatgaagt acggctacac cagcagcaag ctgagcgtca gagtgatggc cctgacacac      360

agacccaaca tcagcatccc cggcacactg gaaagcggac accctagcaa tctgacctgc      420

agcgtgccat gggtttgcga gcagggaacc cctcctatct tctcctggat gtctgccgct      480

cctacctctc tgggccctag aacaacacag agcagcgtgc tgaccatcac acccagacct      540

caggaccaca gcaccaacct gacctgccaa gtgacctttc ctggcgctgg cgtgaccatg      600

gaaagaacca tccagctcaa cgtgtcctac gctccccaga aggtggccat cagcattttc      660

cagggcaaca gcgccgcctt caagatcctg cagaatacca gcagcctgcc tgtgctggaa      720

ggccaggctc tgagactgct gtgtgacgcc gatggcaatc ctcctgctca cctgagctgg      780

ttccagggct tcccagctct gaacgccaca cctatcagca acaccggcgt gctggaactg      840

cctcaagtgg gatctgccga ggaaggcgac ttcacctgta gagcccaaca tcctctgggc      900

agcctgcaga tctccctgag cctgtttgtg cactggaagc ccgaaggcag agctggcgga      960

gtgggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc     1020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1200

aagccgcggg aggagcagta cggtagcacg taccgtgtgg tcagcgtcct caccgtcctg     1260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1380

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1674


<210>  49
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  49

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Ala 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  50
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  50
caagagcggc ggtttcagct ggaaggacct gagagcctga cagtgcaaga gggcctgtgt       60

gtgctggtgc cttgtagact gcctaccaca ctgcccgcca gctactacgg ctacggctat      120

tggtttctgg aaggcgccga tgtgcccgtg gccaccaatg atcctgacga ggaagtgcaa      180

gaagagacac ggggcagatt ccatctgctg tgggacccca gacggaagaa ctgcagcctg      240

agcatcagag atgccagaag gcgggataac gccgcctact tcttcgccct gaagtccaag      300

tggatgaagt acggctacac cagcagcaag ctgagcgtca gagtgatggc cctgacacac      360

agacccaaca tcagcatccc cggcacactg gaaagcggac accctagcaa tctgacctgc      420

agcgtgccat gggtttgcga gcagggaacc cctcctatct tctcctggat gtctgccgct      480

cctacctctc tgggccctag aacaacacag agcagcgtgc tgaccatcac acccagacct      540

caggaccaca gcaccaacct gacctgccaa gtgacctttc ctggcgctgg cgtgaccatg      600

gaaagaacca tccagctcaa cgtgtcctac gctccccaga aggtggccat cagcattttc      660

cagggcaaca gcgccgcctt caagatcctg cagaatacca gcagcctgcc tgtgctggaa      720

ggccaggctc tgagactgct gtgtgacgcc gatggcaatc ctcctgctca cctgagctgg      780

ttccagggct tcccagctct gaacgccaca cctatcagca acaccggcgt gctggaactg      840

cctcaagtgg gatctgccga ggaaggcgac ttcacctgta gagcccaaca tcctctgggc      900

agcctgcaga tctccctgag cctgtttgtg cactggaagc ccgaaggcag agctggcgga      960

gtgggcggag gtggaagtgg cggaggcgga tccgacaaaa ctcacacatg cccaccgtgc     1020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1200

aagccgcggg aggagcagta cggtagcacg taccgtgtgg tcagcgtcct caccgtcctg     1260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtctac     1380

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1674


<210>  51
<211>  467
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(467)
<223>  Siglec 7 FL

<400>  51

Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210>  52
<211>  1769
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1769)
<223>  Siglec 7 FL

<400>  52
gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca       60

accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa      120

ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa      180

gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac      240

tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca      300

gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc      360

cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat      420

gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac      480

cagctctctg tgaacgtgac agccttgacc cacaggccca acatccttat ccccggtacc      540

ctggagtctg gctgcttcca gaatctgacc tgctctgtgc cctgggcctg tgagcagggg      600

acgcccccta tgatctcctg gatggggacc tctgtgtccc ccctgcaccc ctccaccacc      660

cgctcctcag tgctcaccct catcccacag ccccagcacc acggcaccag cctcacctgt      720

caggtgacct tgcctggggc cggcgtgacc acgaacagga ccatccaact caatgtgtcc      780

taccctcctc agaacttgac tgtgactgtc ttccaaggag aaggcacagc atccacagct      840

ctggggaaca gctcatctct ttcagtccta gagggccagt ctctgcgctt ggtctgtgct      900

gttgacagca atccccctgc caggctgagc tggacctgga ggagtctgac cctgtacccc      960

tcacagccct caaaccctct ggtactggag ctgcaagtgc acctggggga tgaaggggaa     1020

ttcacctgtc gagctcagaa ctctctgggt tcccagcacg tttccctgaa cctctccctg     1080

caacaggagt acacaggcaa aatgaggcct gtatcaggag tgttgctggg ggcggtcggg     1140

ggagctggag ccacagccct ggtcttcctc tccttctgtg tcatcttcat tgtagtgagg     1200

tcctgcagga agaaatcggc aaggccagca gcggacgtgg gagacatagg catgaaggat     1260

gcaaacacca tcaggggctc agcctctcag ggtaacctga ctgagtcctg ggcagatgat     1320

aacccccgac accatggcct ggctgcccac tcctcagggg aggaaagaga gatccagtat     1380

gcacccctca gctttcataa gggggagcct caggacctat caggacaaga agccaccaac     1440

aatgagtact cagagatcaa gatccccaag taagaaaatg cagaggctcg ggcttgtttg     1500

agggttcacg acccctccag caaaggagtc tgaggctgat tccagtagaa ttagcagccc     1560

tcaatgctgt gcaacaagac atcagaactt attcctcttg tctaactgaa aatgcatgcc     1620

tgatgaccaa actctccctt tccccatcca atcggtccac actccccgcc ctggcctctg     1680

gtacccacca ttctcctctg tacttctcta aggatgacta ctttagattc cgaatatagt     1740

gagattgtaa cgtgaaaaaa aaaaaaaaa                                       1769


<210>  53
<211>  119
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(119)
<223>  Siglec 7 V-Set (26-144)

<400>  53

Tyr Ser Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Met Cys 
1               5                   10                  15      


Val His Val Arg Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp 
            20                  25                  30          


Ser Asp Pro Val His Gly Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser 
        35                  40                  45              


Trp Lys Ala Pro Val Ala Thr Asn Asn Pro Ala Trp Ala Val Gln Glu 
    50                  55                  60                  


Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro Gln Thr Lys Asn 
65                  70                  75                  80  


Cys Thr Leu Ser Ile Arg Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr 
                85                  90                  95      


Phe Phe Arg Met Glu Lys Gly Asn Ile Lys Trp Asn Tyr Lys Tyr Asp 
            100                 105                 110         


Gln Leu Ser Val Asn Val Thr 
        115                 


<210>  54
<211>  92
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(92)
<223>  Siglec 7 V-Set (Alt. boundary) (31-122)

<400>  54

Gln Ser Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys 
1               5                   10                  15      


Ser Phe Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His 
            20                  25                  30          


Gly Tyr Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val 
        35                  40                  45              


Ala Thr Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg 
    50                  55                  60                  


Phe His Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile 
65                  70                  75                  80  


Arg Asp Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe 
                85                  90          


<210>  55
<211>  221
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(221)
<223>  Siglec 7 V-Set + 1 C2-Set Domain (19-239)

<400>  55

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro 
    210                 215                 220     


<210>  56
<211>  339
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(339)
<223>  Siglec 7 V-Set Domain + 2 C2-Set Domains (Full ECD) (19-357)

<400>  56

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly 
            


<210>  57
<211>  339
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(339)
<223>  Siglec 7 Fragment (19-357)

<400>  57

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly 
            


<210>  58
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) SAX

<400>  58

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly 
            


<210>  59
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) / AS / hIgG1 Fc N297G

<400>  59

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            340                 345                 350         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        355                 360                 365             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    370                 375                 380                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
385                 390                 395                 400 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                405                 410                 415     


Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            420                 425                 430         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        435                 440                 445             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    450                 455                 460                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
465                 470                 475                 480 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                485                 490                 495     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            500                 505                 510         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        515                 520                 525             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    530                 535                 540                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
545                 550                 555                 560 


Ser Leu Ser Leu Ser Pro Gly Lys 
                565             


<210>  60
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) / AS / hIgG1 Fc N297G

<400>  60
cagaagtcca acagaaagga ctacagcctg accatgcaga gcagcgtgac agtgcaagag       60

gggatgtgcg tccacgtccg gtgcagcttt agctaccctg tggacagcca gaccgacagc      120

gatcctgtgc acggctactg gttcagagcc ggcaacgaca tctcttggaa agccccagtg      180

gccaccaaca atcctgcctg ggctgtgcaa gaagagacac gggacagatt ccatctgctg      240

ggcgaccctc agaccaagaa ctgcacactg agcatccggg acgccagaat gtctgacgcc      300

ggcagatact tcttcagaat ggaaaagggc aacatcaagt ggaactataa gtacgaccag      360

ctgagcgtga acgtgacagc cctgacacac agacccaaca ttctgatccc cggcacactg      420

gaaagcggct gcttccagaa tctgacctgc tctgtgcctt gggcctgcga gcagggaaca      480

cctcctatga tcagctggat gggaaccagc gtgtcccctc tgcaccctag caccacaaga      540

tccagcgtgc tgacactgat ccctcagcct cagcaccacg gcacaagcct gacctgtcaa      600

gttacacttc ctggcgctgg cgtgaccacc aacagaacaa tccagctcaa cgtgtcctat      660

cctcctcaga acctgaccgt gaccgtgttc caaggcgagg gcacagcttc tacagccctg      720

ggcaatagca gcagcctgtc tgtgctggaa ggccagtctc tgagactcgt gtgcgccgtg      780

gatagcaacc ctcctgctag actgagctgg acttggcgga gcctgacact gtaccctagc      840

cagcctagca atcccctggt gctggaactg caagtgcacc tgggagatga gggcgagttc      900

acctgtagag cccagaatag cctgggcagc cagcacgtgt ccctgaacct gtctctgcag      960

caagagtaca ccggcaagat gaggcctgtg tctggcgttc tgctgggagc cgtgggagct     1020

agcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     1080

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1140

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1200

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cggtagcacg     1260

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1320

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1380

aaagggcagc cccgagaacc acaggtctac accctgcccc catcccggga ggagatgacc     1440

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1500

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1560

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     1620

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1680

agcctctccc tgtctccggg taaa                                            1704


<210>  61
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) SAX / AS / hIgG1 Fc N297G

<400>  61

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            340                 345                 350         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        355                 360                 365             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    370                 375                 380                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
385                 390                 395                 400 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                405                 410                 415     


Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            420                 425                 430         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        435                 440                 445             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    450                 455                 460                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
465                 470                 475                 480 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                485                 490                 495     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            500                 505                 510         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        515                 520                 525             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    530                 535                 540                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
545                 550                 555                 560 


Ser Leu Ser Leu Ser Pro Gly Lys 
                565             


<210>  62
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) SAX / AS / hIgG1 Fc N297G

<400>  62
cagaagtcca acagaaagga ctacagcctg accatgcaga gcagcgtgac agtgcaagag       60

gggatgtgcg tccacgtccg gtgcagcttt agctaccctg tggacagcca gaccgacagc      120

gatcctgtgc acggctactg gttcagagcc ggcaacgaca tctcttggaa agccccagtg      180

gccaccaaca atcctgcctg ggctgtgcaa gaagagacac gggacagatt ccatctgctg      240

ggcgaccctc agaccaagaa ctgcacactg agcatccggg acgccagaat gtctgacgcc      300

ggcagatact tcttcaagat ggaaaagggc aacatcaagt ggaactataa gtacgaccag      360

ctgagcgtga acgtgacagc cctgacacac agacccaaca ttctgatccc cggcacactg      420

gaaagcggct gcttccagaa tctgacctgc tctgtgcctt gggcctgcga gcagggaaca      480

cctcctatga tcagctggat gggaaccagc gtgtcccctc tgcaccctag caccacaaga      540

tccagcgtgc tgacactgat ccctcagcct cagcaccacg gcacaagcct gacctgtcaa      600

gttacacttc ctggcgctgg cgtgaccacc aacagaacaa tccagctcaa cgtgtcctat      660

cctcctcaga acctgaccgt gaccgtgttc caaggcgagg gcacagcttc tacagccctg      720

ggcaatagca gcagcctgtc tgtgctggaa ggccagtctc tgagactcgt gtgcgccgtg      780

gatagcaacc ctcctgctag actgagctgg acttggcgga gcctgacact gtaccctagc      840

cagcctagca atcccctggt gctggaactg caagtgcacc tgggagatga gggcgagttc      900

acctgtagag cccagaatag cctgggcagc cagcacgtgt ccctgaacct gtctctgcag      960

caagagtaca ccggcaagat gaggcctgtg tctggcgttc tgctgggagc cgtgggagct     1020

agcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     1080

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1140

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1200

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cggtagcacg     1260

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1320

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1380

aaagggcagc cccgagaacc acaggtctac accctgcccc catcccggga ggagatgacc     1440

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1500

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1560

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag     1620

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1680

agcctctccc tgtctccggg taaa                                            1704


<210>  63
<211>  499
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(499)
<223>  Siglec 8 FL

<400>  63

Met Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Thr Lys Gly 
1               5                   10                  15      


Met Glu Gly Asp Arg Gln Tyr Gly Asp Gly Tyr Leu Leu Gln Val Gln 
            20                  25                  30          


Glu Leu Val Thr Val Gln Glu Gly Leu Cys Val His Val Pro Cys Ser 
        35                  40                  45              


Phe Ser Tyr Pro Gln Asp Gly Trp Thr Asp Ser Asp Pro Val His Gly 
    50                  55                  60                  


Tyr Trp Phe Arg Ala Gly Asp Arg Pro Tyr Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Thr Asn Asn Pro Asp Arg Glu Val Gln Ala Glu Thr Gln Gly Arg Phe 
                85                  90                  95      


Gln Leu Leu Gly Asp Ile Trp Ser Asn Asp Cys Ser Leu Ser Ile Arg 
            100                 105                 110         


Asp Ala Arg Lys Arg Asp Lys Gly Ser Tyr Phe Phe Arg Leu Glu Arg 
        115                 120                 125             


Gly Ser Met Lys Trp Ser Tyr Lys Ser Gln Leu Asn Tyr Lys Thr Lys 
    130                 135                 140                 


Gln Leu Ser Val Phe Val Thr Ala Leu Thr His Arg Pro Asp Ile Leu 
145                 150                 155                 160 


Ile Leu Gly Thr Leu Glu Ser Gly His Ser Arg Asn Leu Thr Cys Ser 
                165                 170                 175     


Val Pro Trp Ala Cys Lys Gln Gly Thr Pro Pro Met Ile Ser Trp Ile 
            180                 185                 190         


Gly Ala Ser Val Ser Ser Pro Gly Pro Thr Thr Ala Arg Ser Ser Val 
        195                 200                 205             


Leu Thr Leu Thr Pro Lys Pro Gln Asp His Gly Thr Ser Leu Thr Cys 
    210                 215                 220                 


Gln Val Thr Leu Pro Gly Thr Gly Val Thr Thr Thr Ser Thr Val Arg 
225                 230                 235                 240 


Leu Asp Val Ser Tyr Pro Pro Trp Asn Leu Thr Met Thr Val Phe Gln 
                245                 250                 255     


Gly Asp Ala Thr Ala Ser Thr Ala Leu Gly Asn Gly Ser Ser Leu Ser 
            260                 265                 270         


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asn Ser Asn 
        275                 280                 285             


Pro Pro Ala Arg Leu Ser Trp Thr Arg Gly Ser Leu Thr Leu Cys Pro 
    290                 295                 300                 


Ser Arg Ser Ser Asn Pro Gly Leu Leu Glu Leu Pro Arg Val His Val 
305                 310                 315                 320 


Arg Asp Glu Gly Glu Phe Thr Cys Arg Ala Gln Asn Ala Gln Gly Ser 
                325                 330                 335     


Gln His Ile Ser Leu Ser Leu Ser Leu Gln Asn Glu Gly Thr Gly Thr 
            340                 345                 350         


Ser Arg Pro Val Ser Gln Val Thr Leu Ala Ala Val Gly Gly Ala Gly 
        355                 360                 365             


Ala Thr Ala Leu Ala Phe Leu Ser Phe Cys Ile Ile Phe Ile Ile Val 
    370                 375                 380                 


Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly Asp 
385                 390                 395                 400 


Thr Gly Met Glu Asp Ala Lys Ala Ile Arg Gly Ser Ala Ser Gln Gly 
                405                 410                 415     


Pro Leu Thr Glu Ser Trp Lys Asp Gly Asn Pro Leu Lys Lys Pro Pro 
            420                 425                 430         


Pro Ala Val Ala Pro Ser Ser Gly Glu Glu Gly Glu Leu His Tyr Ala 
        435                 440                 445             


Thr Leu Ser Phe His Lys Val Lys Pro Gln Asp Pro Gln Gly Gln Glu 
    450                 455                 460                 


Ala Thr Asp Ser Glu Tyr Ser Glu Ile Lys Ile His Lys Arg Glu Thr 
465                 470                 475                 480 


Ala Glu Thr Gln Ala Cys Leu Arg Asn His Asn Pro Ser Ser Lys Glu 
                485                 490                 495     


Val Arg Gly 
            


<210>  64
<211>  2967
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2967)
<223>  Siglec 8 FL

<400>  64
agtttctgag agaagaaccc tgaggaacag acgttccctg gcggccctgg cgccttcaaa       60

cccagacatg ctgctgctgc tgctgctgct gcccctgctc tgggggacaa aggggatgga      120

gggagacaga caatatgggg atggttactt gctgcaagtg caggagctgg tgacggtgca      180

ggagggcctg tgtgtccatg tgccctgctc cttctcctac ccccaggatg gctggactga      240

ctctgaccca gttcatggct actggttccg ggcaggagac agaccatacc aagacgctcc      300

agtggccaca aacaacccag acagagaagt gcaggcagag acccagggcc gattccaact      360

ccttggggac atttggagca acgactgctc cctgagcatc agagacgcca ggaagaggga      420

taaggggtca tatttctttc ggctagagag aggaagcatg aaatggagtt acaaatcaca      480

gttgaattac aaaactaagc agctgtctgt gtttgtgaca gccctgaccc ataggcctga      540

catcctcatc ctagggaccc tagagtctgg ccactccagg aacctgacct gctctgtgcc      600

ctgggcctgt aagcagggga caccccccat gatctcctgg attggggcct ccgtgtcctc      660

cccgggcccc actactgccc gctcctcagt gctcaccctt accccaaagc cccaggacca      720

cggcaccagc ctcacctgtc aggtgacctt gcctgggaca ggtgtgacca cgaccagtac      780

cgtccgcctc gatgtgtcct accctccttg gaacttgacc atgactgtct tccaaggaga      840

tgccacagca tccacagccc tgggaaatgg ctcatctctt tcagtccttg agggccagtc      900

tctgcgcctg gtctgtgctg tcaacagcaa tccccctgcc aggctgagct ggacccgggg      960

gagcctgacc ctgtgcccct cacggtcctc aaaccctggg ctgctggagc tgcctcgagt     1020

gcacgtgagg gatgaagggg aattcacctg ccgagctcag aacgctcagg gctcccagca     1080

catttccctg agcctctccc tgcagaatga gggcacaggc acctcaagac ctgtatcaca     1140

agtgacactg gcagcagtcg ggggagctgg agccacagcc ctggccttcc tgtccttctg     1200

catcatcttc atcatagtga ggtcctgcag gaagaaatcg gcaaggccag cagcgggcgt     1260

gggggataca ggcatggaag atgcaaaggc catcaggggc tcggcctctc agggacccct     1320

gactgaatcc tggaaagatg gcaaccccct gaagaagcct cccccagctg ttgccccctc     1380

gtcaggggag gaaggagagc tccattatgc aaccctcagc ttccataaag tgaagcctca     1440

ggacccgcag ggacaggagg ccactgacag tgaatactcg gagatcaaga tccacaagcg     1500

agaaactgca gagactcagg cctgtttgag gaatcacaac ccctccagca aagaagtcag     1560

aggctgattc tcatagaaca agaaccctct agagccccat gctatgcagt aggtcaccag     1620

ggctccctcc tcctgtctaa ccaaaacttg gaccaatgtc tcccctttcc ccggctacca     1680

gggacccatc cctgcctcta gcttctacta cccaccattc tcctctcgac ctctctgagg     1740

ttgactattt tagattccac atagagatga ggtcatgtgg tacttgcctc tctgtgtgtg     1800

gctcatttta cacaaaaaaa tatcccctag gttcatccat gttctctcaa atgacagaat     1860

caagcactga atattttttt ttctttgaga gatggagttt cgctctgttg cccaggctgg     1920

agtgcagtgg ttcaatctct gctcactgca acctccacct cctgggttca aacgattctc     1980

ctgcctcagc ttcccaagta gctggtacta caggcgtgtg tcaccacgcc cagctaattt     2040

ttgtattttt tagtagagac ggggtttcac tataagtggg ccaggctagt ctcaaactcc     2100

tgacctcaag tgatctgcct gccttggcct cccaaagtgc tgggatttca ggcatgagcc     2160

accgcaccca gcttgcattg aatattttca aggagctaaa agaagatttt aaatggtctc     2220

acaaaaacag ataaatattt gcacagatgg gtgtgctaat cattgtgcct tgatggttcc     2280

acgatgtatc cgggtgtgga aatctcactg ggtctctctc aaggccactc ggctactcag     2340

gacagggctg gaatttaaag cctgtccgat tctgaggtct cttctctcat ctagcactga     2400

gtcaagcaat cagcaggctg ggcacccctt agccataagt tttcaggaaa taaattcctt     2460

gagggcattg acttttacaa aagagggagc agcaatggcc tagagtctca ggaacaagac     2520

aggtgcactg aggagatgaa ggccgggacc ccctgcccaa cctgtatggc gggtctgtac     2580

ttattttgtt tacccccaat ttaaaacgtt tttttttatt gcaggttgtt tgtttgatat     2640

ggtttggctg tgtccccacc caaatcttat ctagaattgt aatcagaatt ataatcccca     2700

tgtgttgggg gagggacctg gtgggaggtg ataggatcat gggggtggtt cccccatgct     2760

gttctgatag tgagtgagtt atcacgagat ctgatggttt tgtaagtggt ggtttcccct     2820

gctcttctct cttgcctgcc accatgtaag atgtgcctgg ttccccttcc gccatgattg     2880

taagtttcct gaggcctccc ccgccatgtg gaactgtgag tcaattacac ctctttcatt     2940

tataaattaa aaaaaaaaaa aaaaaaa                                         2967


<210>  65
<211>  463
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(463)
<223>  Siglec 9 FL

<400>  65

Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 
                405                 410                 415     


Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 
            420                 425                 430         


Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 
        435                 440                 445             


Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
    450                 455                 460             


<210>  66
<211>  1737
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1737)
<223>  Siglec 9 FL

<400>  66
tagggcctcc tctaagtctt gagcccgcag ttcctgagag aagaaccctg aggaacagac       60

gttccctcgc ggccctggca cctctaaccc cagacatgct gctgctgctg ctgcccctgc      120

tctgggggag ggagagggcg gaaggacaga caagtaaact gctgacgatg cagagttccg      180

tgacggtgca ggaaggcctg tgtgtccatg tgccctgctc cttctcctac ccctcgcatg      240

gctggattta ccctggccca gtagttcatg gctactggtt ccgggaaggg gccaatacag      300

accaggatgc tccagtggcc acaaacaacc cagctcgggc agtgtgggag gagactcggg      360

accgattcca cctccttggg gacccacata ccaagaattg caccctgagc atcagagatg      420

ccagaagaag tgatgcgggg agatacttct ttcgtatgga gaaaggaagt ataaaatgga      480

attataaaca tcaccggctc tctgtgaatg tgacagcctt gacccacagg cccaacatcc      540

tcatcccagg caccctggag tccggctgcc cccagaatct gacctgctct gtgccctggg      600

cctgtgagca ggggacaccc cctatgatct cctggatagg gacctccgtg tcccccctgg      660

acccctccac cacccgctcc tcggtgctca ccctcatccc acagccccag gaccatggca      720

ccagcctcac ctgtcaggtg accttccctg gggccagcgt gaccacgaac aagaccgtcc      780

atctcaacgt gtcctacccg cctcagaact tgaccatgac tgtcttccaa ggagacggca      840

cagtatccac agtcttggga aatggctcat ctctgtcact cccagagggc cagtctctgc      900

gcctggtctg tgcagttgat gcagttgaca gcaatccccc tgccaggctg agcctgagct      960

ggagaggcct gaccctgtgc ccctcacagc cctcaaaccc gggggtgctg gagctgcctt     1020

gggtgcacct gagggatgca gctgaattca cctgcagagc tcagaaccct ctcggctctc     1080

agcaggtcta cctgaacgtc tccctgcaga gcaaagccac atcaggagtg actcaggggg     1140

tggtcggggg agctggagcc acagccctgg tcttcctgtc cttctgcgtc atcttcgttg     1200

tagtgaggtc ctgcaggaag aaatcggcaa ggccagcagc gggcgtggga gatacgggca     1260

tagaggatgc aaacgctgtc aggggttcag cctctcaggg gcccctgact gaaccttggg     1320

cagaagacag tcccccagac cagcctcccc cagcttctgc ccgctcctca gtgggggaag     1380

gagagctcca gtatgcatcc ctcagcttcc agatggtgaa gccttgggac tcgcggggac     1440

aggaggccac tgacaccgag tactcggaga tcaagatcca cagatgagaa actgcagaga     1500

ctcaccctga ttgagggatc acagcccctc caggcaaggg agaagtcaga ggctgattct     1560

tgtagaatta acagccctca acgtgatgag ctatgataac actatgaatt atgtgcagag     1620

tgaaaagcac acaggcttta gagtcaaagt atctcaaacc tgaatccaca ctgtgccctc     1680

ccttttattt ttttaactaa aagacagaca aattcctaaa aaaaaaaaaa aaaaaaa        1737


<210>  67
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(122)
<223>  Siglec 9 V-Set (23-144)

<400>  67

Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu Cys Val His 
1               5                   10                  15      


Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly 
            20                  25                  30          


Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln 
        35                  40                  45              


Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu 
    50                  55                  60                  


Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe 
                85                  90                  95      


Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg 
            100                 105                 110         


Leu Ser Val Asn Val Thr Ala Leu Thr His 
        115                 120         


<210>  68
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(118)
<223>  Siglec 9 V-Set (Alt. boundary) (23-140)

<400>  68

Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu Cys Val His 
1               5                   10                  15      


Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile Tyr Pro Gly 
            20                  25                  30          


Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn Thr Asp Gln 
        35                  40                  45              


Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val Trp Glu Glu 
    50                  55                  60                  


Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr Lys Asn Cys 
65                  70                  75                  80  


Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly Arg Tyr Phe 
                85                  90                  95      


Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys His His Arg 
            100                 105                 110         


Leu Ser Val Asn Val Thr 
        115             


<210>  69
<211>  218
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(218)
<223>  Siglec 9 V-Set + 1 C2-Set Domain (18-235)

<400>  69

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro 
    210                 215             


<210>  70
<211>  331
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(331)
<223>  Siglec 9 V-Set Domain + 2 C2-Set Domains (Full ECD) (18-348)

<400>  70

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly 
                325                 330     


<210>  71
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y

<400>  71

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser 
                325                 330             


<210>  72
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX

<400>  72

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser 
                325                 330             


<210>  73
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / AS / hIgG1 
       Fc N297G

<400>  73

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  74
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / AS / hIgG1 
       Fc N297G

<400>  74
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcagga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

agcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtaccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagctagcg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacggt agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210>  75
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX / AS / 
       hIgG1 Fc N297G

<400>  75

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  76
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX / AS / 
       hIgG1 Fc N297G

<400>  76
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcaaga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

agcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtaccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagctagcg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacggt agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210>  77
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-145) / AS / hIgG1 Fc (w/ 
       monovalent mutations)

<400>  77

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Asn Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Asn Ser Thr Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  78
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-145) / AS / hIgG1 Fc (w/ 
       monovalent mutations)

<400>  78
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcagga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccgggctagc gacaaaactc acacatgccc accgtgccca      420

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      480

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      540

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      600

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      660

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      720

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtctacacc      780

ctgcccccat cccgggagga gatgaccaag aaccaggtca acctgacctg cctggtcaaa      840

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      900

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcaa tagcacgctc      960

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1020

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1071


<210>  79
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / His Tag

<400>  79

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly His His His His His 
                325                 330                 335     


His His His His His 
            340     


<210>  80
<211>  1026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / His Tag

<400>  80
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcaaga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

agcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtaccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggacaccatc accatcatca ccaccaccat     1020

caccat                                                                1026


<210>  81
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (146-348) / AS / hIgG1 Fc N297G

<400>  81

Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
1               5                   10                  15      


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
            20                  25                  30          


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
        35                  40                  45              


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
    50                  55                  60                  


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
65                  70                  75                  80  


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
                85                  90                  95      


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
        115                 120                 125             


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
    130                 135                 140                 


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
145                 150                 155                 160 


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
                165                 170                 175     


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
            180                 185                 190         


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430         


<210>  82
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (146-348) / AS / hIgG1 Fc N297G

<400>  82
cccaatatcc tcatccccgg caccctggag agcggctgcc cccagaatct tacctgcagc       60

gtaccctggg cctgcgagca gggcacccct ccaatgatca gctggatcgg caccagcgtg      120

agccccctgg accctagtac caccaggagc agcgtgctga ccctgatccc ccagccccag      180

gaccacggaa ccagcctgac ctgccaggtg accttccccg gagccagcgt aaccaccaac      240

aagaccgtgc acctgaacgt gagctaccca ccccaaaacc tgaccatgac cgtgttccag      300

ggcgacggca cggtgagcac cgtactgggc aacggcagct ctctgagcct gcccgagggc      360

cagagcttgc ggctggtctg cgccgtggat gctgtggaca gcaaccctcc cgccaggctg      420

agcctgagct ggaggggcct gaccctgtgc cccagccagc ccagcaatcc cggcgtgctg      480

gagctgccct gggttcacct gagggacgct gccgagttca catgtagggc ccagaacccc      540

ctgggctctc agcaggtgta cctgaacgtg tctcttcaga gtaaggccac cagcggcgtg      600

acccaaggag ctagcgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      660

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      720

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      780

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      840

tacggtagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      900

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      960

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg     1020

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1080

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1140

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1200

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1260

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1296


<210>  83
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K131Q / AS / hIgG1 Fc N297G

<400>  83

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Gln His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  84
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K131Q / AS / hIgG1 Fc N297G

<400>  84
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcagga tggagaaggg gtctatcaag tggaactacc agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

tgcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtgccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagctagcg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacggt agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210>  85
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K100E, A315E / AS / hIgG1 
       Fc N297G

<400>  85

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Glu Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Glu Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  86
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K100E, A315E / AS / hIgG1 
       Fc N297G

<400>  86
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccgaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcagga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

tgcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtgccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgaagccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagctagcg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacggt agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210>  87
<211>  697
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(697)
<223>  Siglec 10 FL

<400>  87

Met Leu Leu Pro Leu Leu Leu Ser Ser Leu Leu Gly Gly Ser Gln Ala 
1               5                   10                  15      


Met Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro 
            20                  25                  30          


Glu Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln 
        35                  40                  45              


Asp Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val 
    50                  55                  60                  


Thr Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg 
65                  70                  75                  80  


Glu Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro 
                85                  90                  95      


Ala Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp 
            100                 105                 110         


Glu Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr 
        115                 120                 125             


Asn Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln 
    130                 135                 140                 


Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val 
145                 150                 155                 160 


Thr Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro 
                165                 170                 175     


Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro 
            180                 185                 190         


Thr Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp 
        195                 200                 205             


His Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val 
    210                 215                 220                 


Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp 
225                 230                 235                 240 


Leu Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln 
                245                 250                 255     


Pro Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu 
            260                 265                 270         


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
        275                 280                 285             


Val Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
    290                 295                 300                 


Pro Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg 
305                 310                 315                 320 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu 
                325                 330                 335     


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
            340                 345                 350         


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
        355                 360                 365             


Pro Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser 
    370                 375                 380                 


Ser Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser 
385                 390                 395                 400 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln 
                405                 410                 415     


Val Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly 
            420                 425                 430         


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu 
        435                 440                 445             


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
    450                 455                 460                 


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
465                 470                 475                 480 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro 
                485                 490                 495     


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
            500                 505                 510         


Leu Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly 
        515                 520                 525             


Ala Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile 
    530                 535                 540                 


Ser Thr Ala Phe Ser Asn Gly Ala Phe Leu Gly Ile Gly Ile Thr Ala 
545                 550                 555                 560 


Leu Leu Phe Leu Cys Leu Ala Leu Ile Ile Met Lys Ile Leu Pro Lys 
                565                 570                 575     


Arg Arg Thr Gln Thr Glu Thr Pro Arg Pro Arg Phe Ser Arg His Ser 
            580                 585                 590         


Thr Ile Leu Asp Tyr Ile Asn Val Val Pro Thr Ala Gly Pro Leu Ala 
        595                 600                 605             


Gln Lys Arg Asn Gln Lys Ala Thr Pro Asn Ser Pro Arg Thr Pro Leu 
    610                 615                 620                 


Pro Pro Gly Ala Pro Ser Pro Glu Ser Lys Lys Asn Gln Lys Lys Gln 
625                 630                 635                 640 


Tyr Gln Leu Pro Ser Phe Pro Glu Pro Lys Ser Ser Thr Gln Ala Pro 
                645                 650                 655     


Glu Ser Gln Glu Ser Gln Glu Glu Leu His Tyr Ala Thr Leu Asn Phe 
            660                 665                 670         


Pro Gly Val Arg Pro Arg Pro Glu Ala Arg Met Pro Lys Gly Thr Gln 
        675                 680                 685             


Ala Asp Tyr Ala Glu Val Lys Phe Gln 
    690                 695         


<210>  88
<211>  3400
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3400)
<223>  Siglec 10 FL

<400>  88
gcccccagga gacccagagg acaactgggc aaggtgggcc ggagagtgtg ggggaaggca       60

aaggagttct gtgagctcag cgtctgaagc tcatttcatg catcaggccc cagggctcag      120

cttccgcctt cggcttcccc ttctgccaag agccctgagc cactcacagc acgaccagag      180

aacaggcctg tctcaggcag gccctgcgcc tcctatgcgg agatgctact gccactgctg      240

ctgtcctcgc tgctgggcgg gtcccaggct atggatggga gattctggat acgagtgcag      300

gagtcagtga tggtgccgga gggcctgtgc atctctgtgc cctgctcttt ctcctacccc      360

cgacaagact ggacagggtc taccccagct tatggctact ggttcaaagc agtgactgag      420

acaaccaagg gtgctcctgt ggccacaaac caccagagtc gagaggtgga aatgagcacc      480

cggggccgat tccagctcac tggggatccc gccaagggga actgctcctt ggtgatcaga      540

gacgcgcaga tgcaggatga gtcacagtac ttctttcggg tggagagagg aagctatgtg      600

agatataatt tcatgaacga tgggttcttt ctaaaagtaa cagccctgac tcagaagcct      660

gatgtctaca tccccgagac cctggagccc gggcagccgg tgacggtcat ctgtgtgttt      720

aactgggcct ttgaggaatg tccaccccct tctttctcct ggacgggggc tgccctctcc      780

tcccaaggaa ccaaaccaac gacctcccac ttctcagtgc tcagcttcac gcccagaccc      840

caggaccaca acaccgacct cacctgccat gtggacttct ccagaaaggg tgtgagcgca      900

cagaggaccg tccgactccg tgtggcctat gcccccagag accttgttat cagcatttca      960

cgtgacaaca cgccagccct ggagccccag ccccagggaa atgtcccata cctggaagcc     1020

caaaaaggcc agttcctgcg gctcctctgt gctgctgaca gccagccccc tgccacactg     1080

agctgggtcc tgcagaacag agtcctctcc tcgtcccatc cctggggccc tagacccctg     1140

gggctggagc tgcccggggt gaaggctggg gattcagggc gctacacctg ccgagcggag     1200

aacaggcttg gctcccagca gcgagccctg gacctctctg tgcagtatcc tccagagaac     1260

ctgagagtga tggtttccca agcaaacagg acagtcctgg aaaaccttgg gaacggcacg     1320

tctctcccag tactggaggg ccaaagcctg tgcctggtct gtgtcacaca cagcagcccc     1380

ccagccaggc tgagctggac ccagagggga caggttctga gcccctccca gccctcagac     1440

cccggggtcc tggagctgcc tcgggttcaa gtggagcacg aaggagagtt cacctgccac     1500

gctcggcacc cactgggctc ccagcacgtc tctctcagcc tctccgtgca ctactccccg     1560

aagctgctgg gcccctcctg ctcctgggag gctgagggtc tgcactgcag ctgctcctcc     1620

caggccagcc cggccccctc tctgcgctgg tggcttgggg aggagctgct ggaggggaac     1680

agcagccagg actccttcga ggtcaccccc agctcagccg ggccctgggc caacagctcc     1740

ctgagcctcc atggagggct cagctccggc ctcaggctcc gctgtgaggc ctggaacgtc     1800

catggggccc agagtggatc catcctgcag ctgccagata agaagggact catctcaacg     1860

gcattctcca acggagcgtt tctgggaatc ggcatcacgg ctcttctttt cctctgcctg     1920

gccctgatca tcatgaagat tctaccgaag agacggactc agacagaaac cccgaggccc     1980

aggttctccc ggcacagcac gatcctggat tacatcaatg tggtcccgac ggctggcccc     2040

ctggctcaga agcggaatca gaaagccaca ccaaacagtc ctcggacccc tcttccacca     2100

ggtgctccct ccccagaatc aaagaagaac cagaaaaagc agtatcagtt gcccagtttc     2160

ccagaaccca aatcatccac tcaagcccca gaatcccagg agagccaaga ggagctccat     2220

tatgccacgc tcaacttccc aggcgtcaga cccaggcctg aggcccggat gcccaagggc     2280

acccaggcgg attatgcaga agtcaagttc caatgagggt ctcttaggct ttaggactgg     2340

gacttcggct agggaggaag gtagagtaag aggttgaaga taacagagtg caaagtttcc     2400

ttctctccct ctctctctct ctttctctct ctctctctct ttctctctct tttaaaaaaa     2460

catctggcca gggcacagtg gctcacgcct gtaatcccag cactttggga ggttgaggtg     2520

ggcagatcgc ctgaggtcgg gagttcgaga ccagcctggc caacttggtg aaaccccgtc     2580

tctactaaaa atacaaaaat tagctgggca tggtggcagg cgcctgtaat cctacctact     2640

tgggaagctg aggcaggaga atcacttgaa cctgggagac ggaggttgca gtgagccaag     2700

atcacaccat tgcacgccag cctgggcaac aaagcgagac tccatctcaa aaaaaaaatc     2760

ctccaaatgg gttgggtgtc tgtaatccca gcactttggg aggctaaggt gggtggattg     2820

cttgagccca ggagttcgag accagcctgg gcaacatggt gaaaccccat ctctacaaaa     2880

aatacaaaac atagctgggc ttggtggtgt gtgcctgtag tcccagctgt cagacattta     2940

aaccagagca actccatctg gaataggagc tgaataaaat gaggctgaga cctactgggc     3000

tgcattctca gacagtggag gcattctaag tcacaggatg agacaggagg tccgtacaag     3060

atacaggtca taaagacttt gctgataaaa cagattgcag taaagaagcc aaccaaatcc     3120

caccaaaacc aagttggcca cgagagtgac ctctggtcgt cctcactgct acactcctga     3180

cagcaccatg acagtttaca aatgccatgg caacatcagg aagttacccg atatgtccca     3240

aaagggggag gaatgaataa tccacccctt gtttagcaaa taagcaagaa ataaccataa     3300

aagtgggcaa ccagcagctc taggcgctgc tcttgtctat ggagtagcca ttcttttgtt     3360

cctttacttt cttaataaac ttgctttcac cttaaaaaaa                           3400


<210>  89
<211>  533
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(533)
<223>  Siglec 10 Fragment (18-550)

<400>  89

Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro Glu 
1               5                   10                  15      


Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln Asp 
            20                  25                  30          


Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr 
        35                  40                  45              


Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu 
    50                  55                  60                  


Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala 
65                  70                  75                  80  


Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu 
                85                  90                  95      


Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn 
            100                 105                 110         


Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys 
        115                 120                 125             


Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr 
    130                 135                 140                 


Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro Ser 
145                 150                 155                 160 


Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro Thr 
                165                 170                 175     


Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp His 
            180                 185                 190         


Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser 
        195                 200                 205             


Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp Leu 
    210                 215                 220                 


Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln Pro 
225                 230                 235                 240 


Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu Arg 
                245                 250                 255     


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
            260                 265                 270         


Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Pro 
        275                 280                 285             


Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr 
    290                 295                 300                 


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
305                 310                 315                 320 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
                325                 330                 335     


Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro 
            340                 345                 350         


Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser Ser 
        355                 360                 365             


Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser Pro 
    370                 375                 380                 


Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln Val 
385                 390                 395                 400 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
                405                 410                 415     


Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu Leu 
            420                 425                 430         


Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser 
        435                 440                 445             


Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu 
    450                 455                 460                 


Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro Ser 
465                 470                 475                 480 


Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu 
                485                 490                 495     


Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly Ala 
            500                 505                 510         


Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile Ser 
        515                 520                 525             


Thr Ala Phe Ser Asn 
    530             


<210>  90
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 10 Fragment (18-550) / (G4S)2 / hIgG1 Fc N297G

<400>  90

Asp Gly Arg Phe Trp Ile Arg Val Gln Glu Ser Val Met Val Pro Glu 
1               5                   10                  15      


Gly Leu Cys Ile Ser Val Pro Cys Ser Phe Ser Tyr Pro Arg Gln Asp 
            20                  25                  30          


Trp Thr Gly Ser Thr Pro Ala Tyr Gly Tyr Trp Phe Lys Ala Val Thr 
        35                  40                  45              


Glu Thr Thr Lys Gly Ala Pro Val Ala Thr Asn His Gln Ser Arg Glu 
    50                  55                  60                  


Val Glu Met Ser Thr Arg Gly Arg Phe Gln Leu Thr Gly Asp Pro Ala 
65                  70                  75                  80  


Lys Gly Asn Cys Ser Leu Val Ile Arg Asp Ala Gln Met Gln Asp Glu 
                85                  90                  95      


Ser Gln Tyr Phe Phe Arg Val Glu Arg Gly Ser Tyr Val Arg Tyr Asn 
            100                 105                 110         


Phe Met Asn Asp Gly Phe Phe Leu Lys Val Thr Ala Leu Thr Gln Lys 
        115                 120                 125             


Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr 
    130                 135                 140                 


Val Ile Cys Val Phe Asn Trp Ala Phe Glu Glu Cys Pro Pro Pro Ser 
145                 150                 155                 160 


Phe Ser Trp Thr Gly Ala Ala Leu Ser Ser Gln Gly Thr Lys Pro Thr 
                165                 170                 175     


Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Arg Pro Gln Asp His 
            180                 185                 190         


Asn Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser 
        195                 200                 205             


Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Arg Asp Leu 
    210                 215                 220                 


Val Ile Ser Ile Ser Arg Asp Asn Thr Pro Ala Leu Glu Pro Gln Pro 
225                 230                 235                 240 


Gln Gly Asn Val Pro Tyr Leu Glu Ala Gln Lys Gly Gln Phe Leu Arg 
                245                 250                 255     


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
            260                 265                 270         


Leu Gln Asn Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Pro 
        275                 280                 285             


Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr 
    290                 295                 300                 


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
305                 310                 315                 320 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
                325                 330                 335     


Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro 
            340                 345                 350         


Val Leu Glu Gly Gln Ser Leu Cys Leu Val Cys Val Thr His Ser Ser 
        355                 360                 365             


Pro Pro Ala Arg Leu Ser Trp Thr Gln Arg Gly Gln Val Leu Ser Pro 
    370                 375                 380                 


Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln Val 
385                 390                 395                 400 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
                405                 410                 415     


Gln His Val Ser Leu Ser Leu Ser Val His Tyr Ser Pro Lys Leu Leu 
            420                 425                 430         


Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser 
        435                 440                 445             


Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu 
    450                 455                 460                 


Leu Leu Glu Gly Asn Ser Ser Gln Asp Ser Phe Glu Val Thr Pro Ser 
465                 470                 475                 480 


Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu 
                485                 490                 495     


Ser Ser Gly Leu Arg Leu Arg Cys Glu Ala Trp Asn Val His Gly Ala 
            500                 505                 510         


Gln Ser Gly Ser Ile Leu Gln Leu Pro Asp Lys Lys Gly Leu Ile Ser 
        515                 520                 525             


Thr Ala Phe Ser Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    530                 535                 540                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
545                 550                 555                 560 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                565                 570                 575     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            580                 585                 590         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        595                 600                 605             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    610                 615                 620                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
625                 630                 635                 640 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                645                 650                 655     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            660                 665                 670         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        675                 680                 685             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    690                 695                 700                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
705                 710                 715                 720 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                725                 730                 735     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            740                 745                 750         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        755                 760                 765             


Gly Lys 
    770 


<210>  91
<211>  2310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 10 Fragment (18-550) / (G4S)2 / hIgG1 Fc N297G

<400>  91
gacggcagat tctggatcag agtgcaagag tccgtgatgg tgcctgaggg cctgtgtatc       60

agcgtgccct gcagcttcag ctaccccaga caggattgga caggcagcac accagcctac      120

ggctactggt ttaaggccgt gaccgaaacc accaagggcg ctccagtggc cacaaaccac      180

cagagcagag aagtggaaat gagcacccgg ggcagattcc agctgacagg cgatcctgcc      240

aagggcaatt gcagcctggt catcagagat gcccagatgc aggacgagag ccagtacttc      300

ttcagagtgg aacggggcag ctacgtgcgg tacaacttta tgaacgacgg attcttcctg      360

aaagtgacgg ccctgacaca gaaacccgac gtgtacatcc ccgagacact ggaacctggc      420

cagcctgtga cagtgatctg cgtgttcaac tgggccttcg aggaatgccc tccaccttcc      480

ttttcttgga ctggcgccgc tctgtctagc cagggcacaa agcctaccac cagccacttt      540

agcgtgctga gcttcacccc tagacctcag gaccacaaca ccgacctgac ctgccacgtg      600

gacttcagca gaaaaggcgt gtcagcccag agaaccgtgc ggctgagagt ggcctatgct      660

cccagagatc tcgtgatcag catcagccgg gacaacaccc ctgctctgga acctcagcct      720

cagggcaatg tgccttacct ggaagcccag aagggccagt tcctgagact gctgtgtgcc      780

gccgattctc agcctcctgc tacactgtct tgggtgctgc agaacagagt gctgagcagc      840

tctcaccctt ggggccctag accactggga cttgaactgc ctggtgtcaa ggcaggcgac      900

agcggcagat acacatgcag agccgagaac agactgggca gccagcagag agcactggat      960

ctgagcgtgc agtaccctcc tgagaacctg agagtgatgg tgtcccaggc caaccggacc     1020

gtgctggaaa atctcggcaa tggcacaagc ctgcctgtgc tggaaggcca gtctctgtgt     1080

ctcgtgtgtg tgacccacag cagccctcca gccagactct cttggacaca gcgaggacag     1140

gtgctgtctc ctagccagcc ttctgatcct ggcgtcctgg aactgcctag agtgcaggtt     1200

gagcacgagg gcgagttcac ctgtcacgcc agacatcctc tgggctctca gcacgtttcc     1260

ctgagcctgt ctgtgcacta cagccctaag ctgctgggcc ctagctgttc ttgggaagcc     1320

gaaggcctgc actgcagctg tagctctcaa gcctctcctg ctcctagcct gagatggtgg     1380

ctgggcgaag aactgctcga gggcaatagc tcccaggaca gcttcgaagt gaccccttct     1440

tctgccggac cttgggccaa tagctctctg tctctgcacg gcggactgag cagtggactg     1500

agactgagat gcgaggcctg gaatgtgcac ggtgctcagt ctggctctat cctgcagctg     1560

cccgataaga agggcctgat cagcaccgcc ttcagcaacg gcggaggtgg aagtggcgga     1620

ggcggatccg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     1680

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1740

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1800

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacggt     1860

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1920

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1980

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     2040

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     2100

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     2160

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     2220

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2280

cagaagagcc tctccctgtc tccgggtaaa                                      2310


<210>  92
<211>  698
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(698)
<223>  Siglec 11 FL

<400>  92

Met Val Pro Gly Gln Ala Gln Pro Gln Ser Pro Glu Met Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu Asn Lys Asp Pro 
            20                  25                  30          


Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val Pro Glu Gly Leu 
        35                  40                  45              


Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg Asp Gly Trp Asp 
    50                  55                  60                  


Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly Arg Thr Ser Pro 
65                  70                  75                  80  


Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser Arg Glu Val Glu 
                85                  90                  95      


Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp Pro Gly Lys Gly 
            100                 105                 110         


Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu Asp Glu Ala Trp 
        115                 120                 125             


Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg His Ser Phe Leu 
    130                 135                 140                 


Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr Lys Lys Pro Asp 
145                 150                 155                 160 


Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro Val Thr Val Ile 
                165                 170                 175     


Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala Pro Ser Phe Ser 
            180                 185                 190         


Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg Pro Ser Thr Ser 
        195                 200                 205             


His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln Asp His Asp Thr 
    210                 215                 220                 


Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly Val Ser Ala Gln 
225                 230                 235                 240 


Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro Lys Asp Leu Ile Ile 
                245                 250                 255     


Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu Leu Gln Gly Asn Val 
            260                 265                 270         


Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg Leu Leu Cys Ala 
        275                 280                 285             


Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val Leu Gln Asp Arg 
    290                 295                 300                 


Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr Leu Gly Leu Glu 
305                 310                 315                 320 


Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr Thr Cys Arg Ala 
                325                 330                 335     


Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu Asp Leu Ser Val Gln 
            340                 345                 350         


Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln Ala Asn Arg Thr 
        355                 360                 365             


Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu Pro Val Leu Glu Gly 
    370                 375                 380                 


Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser Pro Pro Ala Arg 
385                 390                 395                 400 


Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro Ser Gln Pro Ser 
                405                 410                 415     


Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln Met Glu His Glu Gly 
            420                 425                 430         


Glu Phe Thr Cys His Ala Gln His Pro Leu Gly Ser Gln His Val Ser 
        435                 440                 445             


Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu Leu Gly Pro Ser Cys 
    450                 455                 460                 


Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys Ser Ser Gln Ala Ser 
465                 470                 475                 480 


Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu Glu Leu Leu Glu Gly 
                485                 490                 495     


Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro Ser Ser Ala Gly Pro 
            500                 505                 510         


Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly Leu Ser Ser Gly Leu 
        515                 520                 525             


Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly Ala Gln Ser Gly Ser 
    530                 535                 540                 


Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His Gly Gly Gly Leu Gly 
545                 550                 555                 560 


Leu Gly Ala Ala Leu Gly Ala Gly Val Ala Ala Leu Leu Ala Phe Cys 
                565                 570                 575     


Ser Cys Leu Val Val Phe Arg Val Lys Ile Cys Arg Lys Glu Ala Arg 
            580                 585                 590         


Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu Gly Pro Ile 
        595                 600                 605             


Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser Gln Asp His 
    610                 615                 620                 


Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly Glu Glu Gln 
625                 630                 635                 640 


Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg Leu Trp Glu 
                645                 650                 655     


Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile Lys 
            660                 665                 670         


Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly Leu Gln Leu 
        675                 680                 685             


Glu Arg Glu Met Ser Gly Met Val Pro Lys 
    690                 695             


<210>  93
<211>  3183
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3183)
<223>  Siglec 11 FL

<400>  93
cgaggctcct cctctgtgga tggtcactgc ccctccacca ggcttcctgc tggaggagtt       60

tccttcccag ccaggccggc ccagaagcca gatggtcccg ggacaggccc agccccagag      120

cccagagatg ctgctgctgc ccctgctgct gcccgtgctg ggggcggggt ccctgaacaa      180

ggatcccagt tacagtcttc aagtgcagag gcaggtgccg gtgccggagg gcctgtgtgt      240

catcgtgtct tgcaacctct cctacccccg ggatggctgg gacgagtcta ctgctgctta      300

tggctactgg ttcaaaggac ggaccagccc aaagacgggt gctcctgtgg ccactaacaa      360

ccagagtcga gaggtggaaa tgagcacccg ggaccgattc cagctcactg gggatcccgg      420

caaagggagc tgctccttgg tgatcagaga cgcgcagagg gaggatgagg catggtactt      480

ctttcgggtg gagagaggaa gccgtgtgag acatagtttc ctgagcaatg cgttctttct      540

aaaagtaaca gccctgacta agaagcctga tgtctacatc cccgagaccc tggagcccgg      600

gcagccggtg acggtcatct gtgtgtttaa ctgggctttc aagaaatgtc cagccccttc      660

tttctcctgg acgggggctg ccctctcccc tagaagaacc agaccaagca cctcccactt      720

ctcagtgctc agcttcacgc ccagccccca ggaccacgac accgacctca cctgccatgt      780

ggacttctcc agaaagggtg tgagcgcaca gaggaccgtc cgactccgtg tggcctatgc      840

ccccaaagac cttattatca gcatttcaca tgacaacacg tcagccctgg aactccaggg      900

aaacgtcata tatctggaag ttcagaaagg ccagttcctg cggctcctct gtgctgctga      960

cagccagccc cctgccacgc tgagctgggt cctgcaggac agagtcctct cctcgtccca     1020

cccctggggc cccagaaccc tggggctgga gctgcgtggg gtaagggccg gggattcagg     1080

gcgctacacc tgccgagcgg agaacaggct tggctcccag cagcaagccc tggacctctc     1140

tgtgcagtat cctccagaga acctgagagt gatggtttcc caagcaaaca ggacagtcct     1200

ggaaaacctc gggaacggca catccctccc ggtcctggag ggccaaagcc tgcgcctggt     1260

ctgtgtcacc cacagcagcc ccccagccag gctgagctgg acccggtggg gacagaccgt     1320

gggcccctcc cagccctcag accccggggt cctggagctg ccacccattc aaatggagca     1380

cgaaggagag ttcacctgcc acgctcagca ccctctgggc tcccagcacg tctctctcag     1440

cctctccgtg cactaccctc cacagctgct gggcccctcc tgctcctggg aggctgaggg     1500

tctgcactgc agctgctcct cccaggccag cccggccccc tctctgcgct ggtggcttgg     1560

ggaggagctg ctggagggga acagcagtca gggctccttc gaggtcaccc ccagctcagc     1620

cgggccctgg gccaacagct ccctgagcct ccatggaggg ctcagctccg gcctcaggct     1680

ccgctgtaag gcctggaacg tccacggggc ccagagtggc tctgtcttcc agctgctacc     1740

agggaagctg gagcatgggg gaggacttgg cctgggggct gccctgggag ctggcgtcgc     1800

tgccctgctc gctttctgtt cctgccttgt cgtcttcagg gtgaagatct gcaggaagga     1860

agctcgcaag agggcagcag ctgagcagga cgtgccctcc accctgggac ccatctccca     1920

gggtcaccag catgaatgct cggcaggcag ctcccaagac cacccgcccc caggtgcagc     1980

cacctacacc ccggggaagg gggaagagca ggagctccac tatgcctccc tcagcttcca     2040

gggcctgagg ctctgggagc ctgcggacca ggaggccccc agcaccaccg agtactcgga     2100

gatcaagatc cacacaggac agcccctgag gggcccaggc tttgggcttc aattggagag     2160

ggagatgtca gggatggttc caaagtgaag aggtctccat ggcaacagga caccagcaag     2220

tgtgtgggag tcgcactggt gtgacggcca gaactggact cagatttcag ccccatcccc     2280

aatgaagagc ttgagtttga agattatact ttttttgaga cagggtctga ctctgtcctc     2340

caggccagag tccagtggtg caatctcagc tcactgtagc ctcaacctgc caggttgaag     2400

tgagcctccc atttcagcct cccaagtagc tgggactaca attgtgagcc accatgccag     2460

gctcattgtt atatttttag tagagacagg gttttgccat gtttccctgg ctggtctcag     2520

actcctgggc tcaagcaatc tgcccgcctc tgcctcccaa agtgctggga ttacagacgt     2580

gagccaccac agctggctga agattatact ttcaattcag agcgagtttg aagatgacac     2640

tttgaggcat cgtgtctatg gttcattact acagaagctt ctctggatgt gtaaagcaca     2700

ggaaaccagg cagaggaggc acagggtgct ctccagaacg agaagccagc tcctggagtt     2760

gtttgctgca actgccattc cccgttgatg accatgctct tccttcagaa gagggagagt     2820

gagaggacca agtccaagtg gttcccattt gaacatttaa aaaaaaaaaa aaggctgggc     2880

atggtggctc acgcctgtaa tctcaacact ttgggaggct gaagtgggtg gatcacaagt     2940

caggagttca agaccagcct gggcaagatg gtgaaacccc atctctacta aaaatacaaa     3000

aattagccgg gcatggtggc gggcgcctaa aatcccagct actcgggaga ctaggcagag     3060

aattggttga acccgggagg tggaggttgc agtgagccga gatcgtccca ctgcactcca     3120

gcctgggcaa cagagtgaga ctctgtttct aaataaataa atgaaaaaaa aaaaaaaaaa     3180

aaa                                                                   3183


<210>  94
<211>  534
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(534)
<223>  Siglec 11 Fragment (28-561)

<400>  94

Leu Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro 
1               5                   10                  15      


Val Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro 
            20                  25                  30          


Arg Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys 
        35                  40                  45              


Gly Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln 
    50                  55                  60                  


Ser Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly 
65                  70                  75                  80  


Asp Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg 
                85                  90                  95      


Glu Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val 
            100                 105                 110         


Arg His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu 
        115                 120                 125             


Thr Lys Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln 
    130                 135                 140                 


Pro Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro 
145                 150                 155                 160 


Ala Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr 
                165                 170                 175     


Arg Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro 
            180                 185                 190         


Gln Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys 
        195                 200                 205             


Gly Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro 
    210                 215                 220                 


Lys Asp Leu Ile Ile Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu 
225                 230                 235                 240 


Leu Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Thr Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln 
385                 390                 395                 400 


Met Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His 
        515                 520                 525             


Gly Gly Gly Leu Gly Leu 
    530                 


<210>  95
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 11 Fragment (28-561) SAX

<400>  95

Leu Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro 
1               5                   10                  15      


Val Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro 
            20                  25                  30          


Arg Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys 
        35                  40                  45              


Gly Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln 
    50                  55                  60                  


Ser Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly 
65                  70                  75                  80  


Asp Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg 
                85                  90                  95      


Glu Asp Glu Ala Trp Tyr Phe Phe Ala Val Glu Arg Gly Ser Arg Val 
            100                 105                 110         


Arg His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu 
        115                 120                 125             


Thr Lys Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln 
    130                 135                 140                 


Pro Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro 
145                 150                 155                 160 


Ala Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr 
                165                 170                 175     


Arg Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro 
            180                 185                 190         


Gln Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys 
        195                 200                 205             


Gly Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro 
    210                 215                 220                 


Lys Asp Leu Ile Ile Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu 
225                 230                 235                 240 


Leu Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Thr Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln 
385                 390                 395                 400 


Met Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His 
        515                 520                 525             


Gly Gly Gly Leu Gly Leu 
    530                 


<210>  96
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 11 Fragment (28-561) / (G4S)2 / hIgG1 Fc N297G

<400>  96

Leu Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro 
1               5                   10                  15      


Val Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro 
            20                  25                  30          


Arg Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys 
        35                  40                  45              


Gly Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln 
    50                  55                  60                  


Ser Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly 
65                  70                  75                  80  


Asp Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg 
                85                  90                  95      


Glu Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val 
            100                 105                 110         


Arg His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu 
        115                 120                 125             


Thr Lys Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln 
    130                 135                 140                 


Pro Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro 
145                 150                 155                 160 


Ala Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr 
                165                 170                 175     


Arg Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro 
            180                 185                 190         


Gln Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys 
        195                 200                 205             


Gly Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro 
    210                 215                 220                 


Lys Asp Leu Ile Ile Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu 
225                 230                 235                 240 


Leu Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Thr Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln 
385                 390                 395                 400 


Met Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His 
        515                 520                 525             


Gly Gly Gly Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
545                 550                 555                 560 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                565                 570                 575     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            580                 585                 590         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        595                 600                 605             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
    610                 615                 620                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
625                 630                 635                 640 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                645                 650                 655     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            660                 665                 670         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        675                 680                 685             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    690                 695                 700                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
705                 710                 715                 720 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                725                 730                 735     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            740                 745                 750         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        755                 760                 765             


Pro Gly Lys 
    770     


<210>  97
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 11 Fragment (28-561) / (G4S)2 / hIgG1 Fc N297G

<400>  97
ctgaacaagg accccagcta tagcctgcag gtccagagac aggtgccagt gcctgaaggc       60

ctgtgtgtga tcgtgtcctg caacctgagc taccccagag atggctggga tgagagcaca      120

gccgcctacg gctactggtt caagggcaga acaagcccca aaacaggcgc cccagtggcc      180

accaacaacc agagcagaga agtggaaatg agcacccggg acagattcca gctgacaggc      240

gatcctggca agggcagctg ttctctggtc atcagagatg cccagagaga ggacgaggcc      300

tggtacttct tcagagtgga acggggctct agagtgcggc acagctttct gagcaacgca      360

ttcttcctga aagtgacggc cctgaccaag aaacccgacg tgtacatccc cgagacactg      420

gaacctggcc agcctgtgac agtgatctgc gtgttcaact gggccttcaa gaagtgcccc      480

gctcctagct ttagctggac aggcgctgct ctgagcccca gaagaaccag acctagcacc      540

agccacttca gcgtgctgag cttcacccca tctccacagg accacgacac cgatctgacc      600

tgccacgtgg acttcagcag aaagggcgtg tcagcccaga gaaccgtcag actgagagtg      660

gcctacgctc ccaaggacct gatcatcagc atcagccacg acaacacaag cgccctggaa      720

ctgcagggca acgtgatcta cctggaagtg cagaagggcc agttcctgag actgctgtgt      780

gccgccgatt ctcagcctcc tgctacactg tcttgggtgc tgcaggacag agtgctgagc      840

agcagtcatc cttggggccc tagaacactg ggcctcgaac tgagaggtgt cagagccggc      900

gatagcggca gatacacatg cagagccgag aacagactgg gctctcagca gcaggctctg      960

gatctgagcg tgcagtaccc tcctgagaac ctgagagtga tggtgtccca ggccaaccgg     1020

accgtgctgg aaaatctcgg caatggcaca agcctgcctg tgctggaagg ccagagtctg     1080

agactcgtgt gtgtgaccca cagcagccct ccagccagac tgagttggac aagatggggc     1140

cagacagtgg gccctagcca gccttctgat cctggcgttt tggagctgcc tcctatccag     1200

atggaacacg agggcgagtt cacctgtcac gcccaacatc ctctcggcag ccagcatgtg     1260

tctctgagcc tgtctgtgca ctacccacct cagctgctgg gcccttcttg ttcttgggaa     1320

gccgagggcc tgcactgcag ctgtagttct caagcctctc ctgctcctag cctgagatgg     1380

tggctgggcg aagaactgct cgagggcaat agcagccagg gcagctttga agtgacccct     1440

tcttctgccg gaccttgggc caatagctct ctgtctctgc acggcggact gagcagtgga     1500

ctgagactga gatgcaaggc ctggaatgtg cacggcgctc agagcggctc tgtgtttcaa     1560

ctgctgcccg gcaagctgga acatggcgga ggacttggac ttggcggagg tggaagtggc     1620

ggaggcggat ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1680

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1740

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1800

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1860

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1920

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1980

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     2040

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     2100

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2160

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     2220

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2280

acgcagaaga gcctctccct gtctccgggt aaa                                  2313


<210>  98
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 11 Fragment (28-561) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  98

Leu Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro 
1               5                   10                  15      


Val Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro 
            20                  25                  30          


Arg Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys 
        35                  40                  45              


Gly Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln 
    50                  55                  60                  


Ser Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly 
65                  70                  75                  80  


Asp Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg 
                85                  90                  95      


Glu Asp Glu Ala Trp Tyr Phe Phe Ala Val Glu Arg Gly Ser Arg Val 
            100                 105                 110         


Arg His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu 
        115                 120                 125             


Thr Lys Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln 
    130                 135                 140                 


Pro Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro 
145                 150                 155                 160 


Ala Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr 
                165                 170                 175     


Arg Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro 
            180                 185                 190         


Gln Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys 
        195                 200                 205             


Gly Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Tyr Ala Pro 
    210                 215                 220                 


Lys Asp Leu Ile Ile Ser Ile Ser His Asp Asn Thr Ser Ala Leu Glu 
225                 230                 235                 240 


Leu Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu 
                245                 250                 255     


Arg Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp 
            260                 265                 270         


Val Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg 
        275                 280                 285             


Thr Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg 
    290                 295                 300                 


Tyr Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Gln Ala Leu 
305                 310                 315                 320 


Asp Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser 
                325                 330                 335     


Gln Ala Asn Arg Thr Val Leu Glu Asn Leu Gly Asn Gly Thr Ser Leu 
            340                 345                 350         


Pro Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser 
        355                 360                 365             


Ser Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly 
    370                 375                 380                 


Pro Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Pro Ile Gln 
385                 390                 395                 400 


Met Glu His Glu Gly Glu Phe Thr Cys His Ala Gln His Pro Leu Gly 
                405                 410                 415     


Ser Gln His Val Ser Leu Ser Leu Ser Val His Tyr Pro Pro Gln Leu 
            420                 425                 430         


Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Ser Cys 
        435                 440                 445             


Ser Ser Gln Ala Ser Pro Ala Pro Ser Leu Arg Trp Trp Leu Gly Glu 
    450                 455                 460                 


Glu Leu Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Glu Val Thr Pro 
465                 470                 475                 480 


Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ser Leu His Gly Gly 
                485                 490                 495     


Leu Ser Ser Gly Leu Arg Leu Arg Cys Lys Ala Trp Asn Val His Gly 
            500                 505                 510         


Ala Gln Ser Gly Ser Val Phe Gln Leu Leu Pro Gly Lys Leu Glu His 
        515                 520                 525             


Gly Gly Gly Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    530                 535                 540                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
545                 550                 555                 560 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                565                 570                 575     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            580                 585                 590         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        595                 600                 605             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
    610                 615                 620                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
625                 630                 635                 640 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                645                 650                 655     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            660                 665                 670         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        675                 680                 685             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    690                 695                 700                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
705                 710                 715                 720 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                725                 730                 735     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            740                 745                 750         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        755                 760                 765             


Pro Gly Lys 
    770     


<210>  99
<211>  2313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 11 Fragment (28-561) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  99
ctgaacaagg accccagcta tagcctgcag gtccagagac aggtgccagt gcctgaaggc       60

ctgtgtgtga tcgtgtcctg caacctgagc taccccagag atggctggga tgagagcaca      120

gccgcctacg gctactggtt caagggcaga acaagcccca aaacaggcgc cccagtggcc      180

accaacaacc agagcagaga agtggaaatg agcacccggg acagattcca gctgacaggc      240

gatcctggca agggcagctg ttctctggtc atcagagatg cccagagaga ggacgaggcc      300

tggtacttct tcgccgtgga acggggctct agagtgcggc acagctttct gagcaacgca      360

ttcttcctga aagtgacggc cctgaccaag aaacccgacg tgtacatccc cgagacactg      420

gaacctggcc agcctgtgac agtgatctgc gtgttcaact gggccttcaa gaagtgcccc      480

gctcctagct ttagctggac aggcgctgct ctgagcccca gaagaaccag acctagcacc      540

agccacttca gcgtgctgag cttcacccca tctccacagg accacgacac cgatctgacc      600

tgccacgtgg acttcagcag aaagggcgtg tcagcccaga gaaccgtcag actgagagtg      660

gcctacgctc ccaaggacct gatcatcagc atcagccacg acaacacaag cgccctggaa      720

ctgcagggca acgtgatcta cctggaagtg cagaagggcc agttcctgag actgctgtgt      780

gccgccgatt ctcagcctcc tgctacactg tcttgggtgc tgcaggacag agtgctgagc      840

agcagtcatc cttggggccc tagaacactg ggcctcgaac tgagaggtgt cagagccggc      900

gatagcggca gatacacatg cagagccgag aacagactgg gctctcagca gcaggctctg      960

gatctgagcg tgcagtaccc tcctgagaac ctgagagtga tggtgtccca ggccaaccgg     1020

accgtgctgg aaaatctcgg caatggcaca agcctgcctg tgctggaagg ccagagtctg     1080

agactcgtgt gtgtgaccca cagcagccct ccagccagac tgagttggac aagatggggc     1140

cagacagtgg gccctagcca gccttctgat cctggcgttt tggagctgcc tcctatccag     1200

atggaacacg agggcgagtt cacctgtcac gcccaacatc ctctcggcag ccagcatgtg     1260

tctctgagcc tgtctgtgca ctacccacct cagctgctgg gcccttcttg ttcttgggaa     1320

gccgagggcc tgcactgcag ctgtagttct caagcctctc ctgctcctag cctgagatgg     1380

tggctgggcg aagaactgct cgagggcaat agcagccagg gcagctttga agtgacccct     1440

tcttctgccg gaccttgggc caatagctct ctgtctctgc acggcggact gagcagtgga     1500

ctgagactga gatgcaaggc ctggaatgtg cacggcgctc agagcggctc tgtgtttcaa     1560

ctgctgcccg gcaagctgga acatggcgga ggacttggac ttggcggagg tggaagtggc     1620

ggaggcggat ccgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1680

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1740

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1800

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1860

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1920

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1980

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     2040

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     2100

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2160

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     2220

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2280

acgcagaaga gcctctccct gtctccgggt aaa                                  2313


<210>  100
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(595)
<223>  Siglec 12 FL

<400>  100

Met Leu Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Cys Gly Arg Val 
1               5                   10                  15      


Gly Ala Lys Glu Gln Lys Asp Tyr Leu Leu Thr Met Gln Lys Ser Val 
            20                  25                  30          


Thr Val Gln Glu Gly Leu Cys Val Ser Val Leu Cys Ser Phe Ser Tyr 
        35                  40                  45              


Pro Gln Asn Gly Trp Thr Ala Ser Asp Pro Val His Gly Tyr Trp Phe 
    50                  55                  60                  


Arg Ala Gly Asp His Val Ser Arg Asn Ile Pro Val Ala Thr Asn Asn 
65                  70                  75                  80  


Pro Ala Arg Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
                85                  90                  95      


Gly Asp Pro Gln Asn Lys Asp Cys Thr Leu Ser Ile Arg Asp Thr Arg 
            100                 105                 110         


Glu Ser Asp Ala Gly Thr Tyr Val Phe Cys Val Glu Arg Gly Asn Met 
        115                 120                 125             


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Ser 
    130                 135                 140                 


Gln Asp Leu Leu Ser Arg Tyr Arg Leu Glu Val Pro Glu Ser Val Thr 
145                 150                 155                 160 


Val Gln Glu Gly Leu Cys Val Ser Val Pro Cys Ser Val Leu Tyr Pro 
                165                 170                 175     


His Tyr Asn Trp Thr Ala Ser Ser Pro Val Tyr Gly Ser Trp Phe Lys 
            180                 185                 190         


Glu Gly Ala Asp Ile Pro Trp Asp Ile Pro Val Ala Thr Asn Thr Pro 
        195                 200                 205             


Ser Gly Lys Val Gln Glu Asp Thr His Gly Arg Phe Leu Leu Leu Gly 
    210                 215                 220                 


Asp Pro Gln Thr Asn Asn Cys Ser Leu Ser Ile Arg Asp Ala Arg Lys 
225                 230                 235                 240 


Gly Asp Ser Gly Lys Tyr Tyr Phe Gln Val Glu Arg Gly Ser Arg Lys 
                245                 250                 255     


Trp Asn Tyr Ile Tyr Asp Lys Leu Ser Val His Val Thr Ala Leu Thr 
            260                 265                 270         


His Met Pro Thr Phe Ser Ile Pro Gly Thr Leu Glu Ser Gly His Pro 
        275                 280                 285             


Arg Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro 
    290                 295                 300                 


Pro Thr Ile Thr Trp Met Gly Ala Ser Val Ser Ser Leu Asp Pro Thr 
305                 310                 315                 320 


Ile Thr Arg Ser Ser Met Leu Ser Leu Ile Pro Gln Pro Gln Asp His 
                325                 330                 335     


Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val Thr 
            340                 345                 350         


Met Thr Arg Ala Val Arg Leu Asn Ile Ser Tyr Pro Pro Gln Asn Leu 
        355                 360                 365             


Thr Met Thr Val Phe Gln Gly Asp Gly Thr Ala Ser Thr Thr Leu Arg 
    370                 375                 380                 


Asn Gly Ser Ala Leu Ser Val Leu Glu Gly Gln Ser Leu His Leu Val 
385                 390                 395                 400 


Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly 
                405                 410                 415     


Ser Leu Thr Leu Ser Pro Ser Gln Ser Ser Asn Leu Gly Val Leu Glu 
            420                 425                 430         


Leu Pro Arg Val His Val Lys Asp Glu Gly Glu Phe Thr Cys Arg Ala 
        435                 440                 445             


Gln Asn Pro Leu Gly Ser Gln His Ile Ser Leu Ser Leu Ser Leu Gln 
    450                 455                 460                 


Asn Glu Tyr Thr Gly Lys Met Arg Pro Ile Ser Gly Val Thr Leu Gly 
465                 470                 475                 480 


Ala Phe Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Tyr Phe Cys 
                485                 490                 495     


Ile Ile Phe Val Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro 
            500                 505                 510         


Ala Val Gly Val Gly Asp Thr Gly Met Glu Asp Ala Asn Ala Val Arg 
        515                 520                 525             


Gly Ser Ala Ser Gln Gly Pro Leu Ile Glu Ser Pro Ala Asp Asp Ser 
    530                 535                 540                 


Pro Pro His His Ala Pro Pro Ala Leu Ala Thr Pro Ser Pro Glu Glu 
545                 550                 555                 560 


Gly Glu Ile Gln Tyr Ala Ser Leu Ser Phe His Lys Ala Arg Pro Gln 
                565                 570                 575     


Tyr Pro Gln Glu Gln Glu Ala Ile Gly Tyr Glu Tyr Ser Glu Ile Asn 
            580                 585                 590         


Ile Pro Lys 
        595 


<210>  101
<211>  1788
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1788)
<223>  Siglec 12 FL

<400>  101
atgctactgc tgctgctact gctgccaccc ctgctctgtg ggagagtggg ggctaaggaa       60

cagaaggatt acctgctgac aatgcagaag tccgtgacgg tgcaggaggg cctgtgtgtc      120

tctgtgcttt gctccttctc ctacccccaa aatggctgga ctgcctccga tccagttcat      180

ggctactggt tccgggcagg ggaccatgta agccggaaca ttccagtggc cacaaacaac      240

ccagctcgag cagtgcagga ggagactcgg gaccgattcc acctccttgg ggacccacag      300

aacaaggatt gtaccctgag catcagagac accagagaga gtgatgcagg gacatacgtc      360

ttttgtgtag agagaggaaa tatgaaatgg aattataaat atgaccagct ctctgtgaat      420

gtgacagcgt cccaggacct actgtcaaga tacaggctgg aggtgccaga gtcggtgact      480

gtgcaggagg gtctgtgtgt ctctgtgccc tgcagtgtcc tttaccccca ttacaactgg      540

actgcctcta gccctgttta tggatcctgg ttcaaggaag gggccgatat accatgggat      600

attccagtgg ccacaaacac cccaagtgga aaagtgcaag aggataccca cggtcgattc      660

ctcctccttg gggacccaca gaccaacaac tgctccctga gcatcagaga tgccaggaag      720

ggggattcag ggaagtacta cttccaggtg gagagaggaa gcaggaaatg gaactacata      780

tatgacaagc tctctgtgca tgtgacagcc ctgactcaca tgcccacctt ctccatcccg      840

gggaccctgg agtctggcca ccccaggaac ctgacctgct ctgtgccctg ggcctgtgaa      900

caggggacgc cccccacgat cacctggatg ggggcctccg tgtcctccct ggaccccact      960

atcactcgct cctcgatgct cagcctcatc ccacagcccc aggaccatgg caccagcctc     1020

acctgtcagg tgaccttgcc tggggccggc gtgaccatga ccagggctgt ccgactcaac     1080

atatcctatc ctcctcagaa cttgaccatg actgtcttcc aaggagatgg cacagcatcc     1140

acaaccttga ggaatggctc ggccctttca gtcctggagg gccagtccct gcaccttgtc     1200

tgtgctgtcg acagcaatcc ccctgccagg ctgagctgga cctgggggag cctgaccctg     1260

agcccctcac agtcctcgaa ccttggggtg ctggagctgc ctcgagtgca tgtgaaggat     1320

gaaggggaat tcacctgccg agctcagaac cctctaggct cccagcacat ttccctgagc     1380

ctctccctgc aaaacgagta cacaggcaaa atgaggccta tatcaggagt gacgctaggg     1440

gcattcgggg gagctggagc cacagccctg gtcttcctgt acttctgcat catcttcgtt     1500

gtagtgaggt cctgcaggaa gaaatcggca aggccagcag tgggcgtggg ggatacaggc     1560

atggaggacg caaacgctgt caggggctca gcctctcagg gacccctgat tgaatccccg     1620

gcagatgaca gccccccaca ccatgctccg ccagccctgg ccaccccctc cccagaggaa     1680

ggagagatcc agtatgcatc cctcagcttc cacaaagcga ggcctcagta cccacaggaa     1740

caggaggcca tcggctatga gtactccgag atcaacatcc ccaagtga                  1788


<210>  102
<211>  396
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(396)
<223>  Siglec 14 FL

<400>  102

Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln 
1               5                   10                  15      


Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
        35                  40                  45              


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
    50                  55                  60                  


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
65                  70                  75                  80  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
                85                  90                  95      


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
            100                 105                 110         


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
        115                 120                 125             


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
    130                 135                 140                 


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
145                 150                 155                 160 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
                165                 170                 175     


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
            180                 185                 190         


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
        195                 200                 205             


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
    210                 215                 220                 


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
225                 230                 235                 240 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
                245                 250                 255     


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
            260                 265                 270         


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
        275                 280                 285             


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
    290                 295                 300                 


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
305                 310                 315                 320 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
                325                 330                 335     


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
            340                 345                 350         


Ser Trp Pro Leu Val Leu Thr Leu Ile Arg Gly Ala Leu Met Gly Ala 
        355                 360                 365             


Gly Phe Leu Leu Thr Tyr Gly Leu Thr Trp Ile Tyr Tyr Thr Arg Cys 
    370                 375                 380                 


Gly Gly Pro Gln Gln Ser Arg Ala Glu Arg Pro Gly 
385                 390                 395     


<210>  103
<211>  1191
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1191)
<223>  Siglec 14 FL

<400>  103
atgctgcccc tgctgctgct gcccctgctg tggggggggt ccctgcagga gaagccagtg       60

tacgagctgc aagtgcagaa gtcggtgacg gtgcaggagg gcctgtgcgt ccttgtgccc      120

tgctccttct cttacccctg gagatcctgg tattcctctc ccccactcta cgtctactgg      180

ttccgggacg gggagatccc atactacgct gaggttgtgg ccacaaacaa cccagacaga      240

agagtgaagc cagagaccca gggccgattc cgcctccttg gggatgtcca gaagaagaac      300

tgctccctga gcatcggaga tgccagaatg gaggacacgg gaagctattt cttccgcgtg      360

gagagaggaa gggatgtaaa atatagctac caacagaata agctgaactt ggaggtgaca      420

gccctgatag agaaacccga catccacttt ctggagcctc tggagtccgg ccgccccaca      480

aggctgagct gcagccttcc aggatcctgt gaagcgggac cacctctcac attctcctgg      540

acggggaatg ccctcagccc cctggacccc gagaccaccc gctcctcgga gctcaccctc      600

acccccaggc ccgaggacca tggcaccaac ctcacctgtc aggtgaaacg ccaaggagct      660

caggtgacca cggagagaac tgtccagctc aatgtctcct atgctccaca gaacctcgcc      720

atcagcatct tcttcagaaa tggcacaggc acagccctgc ggatcctgag caatggcatg      780

tcggtgccca tccaggaggg ccagtccctg ttcctcgcct gcacagttga cagcaacccc      840

cctgcctcac tgagctggtt ccgggaggga aaagccctca atccttccca gacctcaatg      900

tctgggaccc tggagctgcc taacatagga gctagagagg gaggggaatt cacctgccgg      960

gttcagcatc cgctgggctc ccagcacctg tccttcatcc tttctgtgca gagaagctcc     1020

tcttcctgca tatgtgtaac tgagaaacag cagggctcct ggcccctcgt cctcaccctg     1080

atcagggggg ctctcatggg ggctggcttc ctcctcacct atggcctcac ctggatctac     1140

tataccaggt gtggaggccc ccagcagagc agggctgaga ggcctggctg a              1191


<210>  104
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(328)
<223>  Siglec 15 FL

<400>  104

Met Glu Lys Ser Ile Trp Leu Leu Ala Cys Leu Ala Trp Val Leu Pro 
1               5                   10                  15      


Thr Gly Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr Val Ala Leu Leu Leu Gly Ala Leu Gly 
            260                 265                 270         


Phe Lys Ala Leu Leu Leu Leu Gly Val Leu Ala Ala Arg Ala Ala Arg 
        275                 280                 285             


Arg Arg Pro Glu His Leu Asp Thr Pro Asp Thr Pro Pro Arg Ser Gln 
    290                 295                 300                 


Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Asn Pro Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Thr Met Cys Ser Pro 
                325             


<210>  105
<211>  987
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(987)
<223>  Siglec 15 FL

<400>  105
atggaaaagt ccatctggct gctggcctgc ttggcgtggg ttctcccgac aggctcattt       60

gtgagaacta aaatagatac tacggagaac ttgctcaaca cagaggtgca cagctcgcca      120

gcgcagcgct ggtccatgca ggtgccaccc gaggtgagcg cggaggcagg cgacgcggca      180

gtgctgccct gcaccttcac gcacccgcac cgccactacg acgggccgct gacggccatc      240

tggcgcgcgg gcgagcccta tgcgggcccg caggtgttcc gctgcgctgc ggcgcggggc      300

agcgagctct gccagacggc gctgagcctg cacggccgct tccggctgct gggcaacccg      360

cgccgcaacg acctctcgct gcgcgtcgag cgcctcgccc tggctgacga ccgccgctac      420

ttctgccgcg tcgagttcgc cggcgacgtc catgaccgct acgagagccg ccacggcgtc      480

cggctgcacg tgacagccgc gccgcggatc gtcaacatct cggtgctgcc cagtccggct      540

cacgccttcc gcgcgctctg cactgccgaa ggggagccgc cgcccgccct cgcctggtcc      600

ggcccggccc tgggcaacag cttggcagcc gtgcggagcc cgcgtgaggg tcacggccac      660

ctagtgaccg ccgaactgcc cgcactgacc catgacggcc gctacacgtg tacggccgcc      720

aacagcctgg gccgctccga ggccagcgtc tacctgttcc gcttccatgg cgccagcggg      780

gcctcgacgg tcgccctcct gctcggcgct ctcggcttca aggcgctgct gctgctcggg      840

gtcctggccg cccgcgctgc ccgccgccgc ccagagcatc tggacacccc ggacacccca      900

ccacggtccc aggcccagga gtccaattat gaaaatttga gccagatgaa cccccggagc      960

ccaccagcca ccatgtgctc accgtga                                          987


<210>  106
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(244)
<223>  Siglec 15 Fragment (20-263)

<400>  106

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr 
                


<210>  107
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) SAX

<400>  107

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Ala Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr 
                


<210>  108
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) / (G4S)2 / hIgG1 Fc N297G

<400>  108

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  109
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) / (G4S)2 / hIgG1 Fc N297G

<400>  109
tttgtgcgga ccaagatcga caccaccgag aacctgctga acaccgaggt gcactctagc       60

cctgctcagc ggtggtctat gcaggtccca cctgaagtgt ctgccgaagc tggggatgct      120

gctgtgctgc cttgcacctt tacacaccct caccggcact acgatggccc tctgacagcc      180

atttggagag ccggcgaacc ttatgccgga ccacaggtgt tcagatgcgc tgccgctaga      240

ggctctgagc tgtgtcagac agccctgtct ctgcacggca gattcagact gctgggcaac      300

cccagaagaa acgacctgag cctgagagtg gaaagactgg ccctggccga cgacagacgg      360

tacttctgca gagtggaatt tgccggcgac gtgcacgaca gatacgagtc tagacacggc      420

gtgcggctgc acgttacagc cgctcctaga atcgtgaaca tcagcgtgct gccctctcca      480

gctcacgcct ttagagccct gtgtacagcc gaaggcgaac ctcctcctgc tcttgcttgg      540

agtggacccg ctctgggaaa ttctctggcc gccgtcagaa gccctagaga aggacacgga      600

cacctggtca cagccgaact gcctgctctg acacacgacg gcagatacac atgcacagcc      660

gccaatagcc tgggcagatc tgaggccagc gtgtacctgt tcagattcca tggcgccagc      720

ggcgcctcta caggcggagg tggaagtggc ggaggcggat ccgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac ggtagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtctaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  110
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  110

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Ala Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  111
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) SAX / (G4S)2 / hIgG1 Fc 
       N297G

<400>  111
tttgtgcgga ccaagatcga caccaccgag aacctgctga acaccgaggt gcactctagc       60

cctgctcagc ggtggtctat gcaggtccca cctgaagtgt ctgccgaagc tggggatgct      120

gctgtgctgc cttgcacctt tacacaccct caccggcact acgatggccc tctgacagcc      180

atttggagag ccggcgaacc ttatgccgga ccacaggtgt tcagatgcgc tgccgctaga      240

ggctctgagc tgtgtcagac agccctgtct ctgcacggca gattcagact gctgggcaac      300

cccagaagaa acgacctgag cctgagagtg gaaagactgg ccctggccga cgacagacgg      360

tacttctgcg ccgtggaatt tgccggcgac gtgcacgaca gatacgagtc tagacacggc      420

gtgcggctgc acgttacagc cgctcctaga atcgtgaaca tcagcgtgct gccctctcca      480

gctcacgcct ttagagccct gtgtacagcc gaaggcgaac ctcctcctgc tcttgcttgg      540

agtggacccg ctctgggaaa ttctctggcc gccgtcagaa gccctagaga aggacacgga      600

cacctggtca cagccgaact gcctgctctg acacacgacg gcagatacac atgcacagcc      660

gccaatagcc tgggcagatc tgaggccagc gtgtacctgt tcagattcca tggcgccagc      720

ggcgcctcta caggcggagg tggaagtggc ggaggcggat ccgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac ggtagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtctaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  112
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Mouse Siglec 15 Fragment / (G4S)2 / hIgG1 Fc N297G

<400>  112

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Ala Glu 
            20                  25                  30          


Val Ser Ala Ala Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Ile Asn Ile Ser Val Leu Pro Gly Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Gly Ser Ala Ala Val 
            180                 185                 190         


Pro Ser Ser Gly Gln Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Asn His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  113
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Mouse Siglec 15 Fragment / (G4S)2 / hIgG1 Fc N297G

<400>  113
ttcgtgcgga ccaagatcga caccaccgag aacctgctga acaccgaggt gcactctagc       60

cctgctcagc ggtggtctat gcaggtccca gctgaagtgt ctgctgctgc tggggatgct      120

gctgtgctgc cttgcacctt tacacaccct caccggcact acgatggccc tctgacagcc      180

atttggagag ccggcgaacc ttatgccgga ccacaggtgt tcagatgcgc tgccgctaga      240

ggctctgagc tgtgtcagac agccctgtct ctgcacggca gattcagact gctgggcaac      300

cccagaagaa acgacctgag cctgagagtg gaaagactgg ccctggccga cgacagacgg      360

tacttctgca gagtggaatt tgccggcgac gtgcacgaca gatacgagtc tagacacggc      420

gtgcggctgc acgttacagc cgctcctaga atcatcaaca tcagcgtgct gcccggacct      480

gctcacgctt ttagagccct gtgtacagcc gagggcgaac ctcctcctgc tcttgcttgg      540

agtggacccg ctctcggaaa tggatctgcc gccgttccta gctctggcca aggacacgga      600

catctggtca cagccgaact gcccgctctg aaccacgacg gcagatacac atgtaccgcc      660

gccaatagcc tgggcagatc tgaggctagc gtgtacctgt tcagattcca cggcgccagc      720

ggagcctcta caggcggagg tggaagtggc ggaggcggat ccgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac ggtagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtctaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  114
<211>  481
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(481)
<223>  Siglec 16 FL

<400>  114

Met Leu Leu Leu Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu 
1               5                   10                  15      


Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val 
            20                  25                  30          


Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg 
        35                  40                  45              


Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly 
    50                  55                  60                  


Trp Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser 
65                  70                  75                  80  


Arg Glu Val Glu Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp 
                85                  90                  95      


Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu 
            100                 105                 110         


Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg 
        115                 120                 125             


His Ser Phe Val Asn Asn Leu Phe Phe Leu Lys Val Thr Ala Leu Thr 
    130                 135                 140                 


Gln Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro 
145                 150                 155                 160 


Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala 
                165                 170                 175     


Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg 
            180                 185                 190         


Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln 
        195                 200                 205             


Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly 
    210                 215                 220                 


Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Ser Leu Glu Leu 
225                 230                 235                 240 


Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg 
                245                 250                 255     


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
            260                 265                 270         


Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr 
        275                 280                 285             


Leu Gly Leu Glu Leu Arg Gly Val Arg Ala Gly Asp Ser Gly Arg Tyr 
    290                 295                 300                 


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
305                 310                 315                 320 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
                325                 330                 335     


Ala Asn Arg Thr Val Leu Glu Asn Leu Arg Asn Gly Thr Ser Leu Arg 
            340                 345                 350         


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser 
        355                 360                 365             


Pro Pro Ala Arg Leu Ser Trp Thr Arg Trp Gly Gln Thr Val Gly Pro 
    370                 375                 380                 


Ser Gln Pro Ser Asp Pro Gly Val Leu Glu Leu Pro Arg Val Gln Met 
385                 390                 395                 400 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
                405                 410                 415     


Gln Arg Val Ser Leu Ser Phe Ser Val His Cys Lys Ser Gly Pro Met 
            420                 425                 430         


Thr Gly Val Val Leu Val Ala Val Gly Glu Val Ala Met Lys Ile Leu 
        435                 440                 445             


Leu Leu Cys Leu Cys Leu Ile Leu Leu Arg Val Arg Ser Cys Arg Arg 
    450                 455                 460                 


Lys Ala Ala Arg Ala Ala Leu Gly Met Glu Ala Ala Asp Ala Val Thr 
465                 470                 475                 480 


Asp 
    


<210>  115
<211>  3811
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3811)
<223>  Siglec 16 FL

<400>  115
agatggtccc gggacaggcc cagccccaga gcccagagat gctgctgctg cccctgctgc       60

tgcccgtgct gggggcgggg tccctgaaca aggatcccag ttacagtctt caagtgcaga      120

ggcaggtgcc ggtgccggag ggcctgtgtg tcatcgtgtc ttgcaacctc tcctaccccc      180

gggatggctg ggacgagtct actgctgctt atggctactg gttcaaagga tggaccagcc      240

caaagacggg tgctcctgtg gccactaaca accagagtcg agaggtggaa atgagcaccc      300

gggaccgatt ccagctcact ggggatcccg gcaaagggag ctgctccttg gtgatcagag      360

acgcgcagag ggaggatgag gcatggtact tctttcgggt ggagagagga agccgtgtga      420

gacatagttt cgtgaacaat ttgttctttc taaaagtaac agccctgact cagaagcctg      480

atgtctacat ccccgagacc ctggagcccg ggcagccggt gacggtcatc tgtgtgttta      540

actgggcttt caagaaatgt ccagcccctt ctttctcctg gacgggggct gccctctccc      600

ctagaagaac cagaccaagc acctcccact tctcagtgct cagcttcacg cccagccccc      660

aggaccacga caccgacctc acctgccatg tggacttctc cagaaagggt gtgagcgcac      720

agaggaccgt ccgactccgt gtggcctccc tggaactcca gggaaacgtc atatatctgg      780

aagttcagaa aggccagttc ctgcggctcc tctgtgctgc tgacagccag ccccctgcca      840

cgctgagctg ggtcctgcag gacagagtcc tctcctcgtc ccacccctgg ggccccagaa      900

ccctggggct ggagctgcgt ggggtaaggg ccggggattc agggcgctac acctgccgag      960

cggagaacag gcttggctcc cagcagcgag ccctggacct ctctgtgcag tatcctccag     1020

agaacctgag agtgatggtt tcccaagcaa acaggacagt cctggaaaac ctgaggaacg     1080

gcacatccct ccgggtcctg gagggccaaa gcctgcgtct ggtctgtgtc acacacagca     1140

gccccccagc caggctgagc tggacccggt ggggacagac cgtgggcccc tcccagccct     1200

cagaccctgg ggtcctggag ctgcctcggg ttcaaatgga gcacgaagga gagttcacct     1260

gccacgctcg gcacccgctg ggctcccagc gcgtctctct cagcttctcc gtgcactgca     1320

aatcagggcc catgacgggg gtggttctgg tggctgttgg ggaggtggct atgaagatcc     1380

tgcttctctg cctctgcctc atcctcctca gagtgaggtc ttgcaggagg aaggcagcaa     1440

gggcagcatt gggcatggag gctgcagacg ctgtcacgga ctaatctcca gactccagac     1500

tgcttccaga tgcctcctca tccagttcct ccacagtctg agcggccgtg tttcctctgc     1560

aggctttgca tggtctgtcc cctgctggac tctcctgatc cctcctttcc ctgtcaccca     1620

acatctcccc aaaccctccg ggccaaggac tctgcggctc ttgacacttt gcacgtgtag     1680

tttcttctcc tgaaacaccc ttccctcctg ccaaaccacg tctggaccct ccttcaggtt     1740

cacttttttt tttttttttt gagacacagt ctcactttgt cacccaggct ggagtgcagt     1800

ggcgcgatct cggctcactg caacctctgt ctcccaggtt caagcgattc tcatgtctca     1860

gcctcctgag tagctgggat tataggcgcc cgccaccacg cctggctcat ttttgtattt     1920

ttggtagaga cagggtttca ccatgtcggc caggctggtc ttgaactccc gacttcaggt     1980

gatccgccag cctcggcctc ccaaagtggt ggggttacat gtgtgagcca ccgtgcccag     2040

ccagctgtgt cttctttttg caggatttac ttacaaaatt ccttgcagct gcagtctgcg     2100

ttccacccac atcctaatat ggtgtttgcg gtggtcacat ccaacttcct tcctcctcca     2160

tccatggaac gtgcattagg gaggaaccac acgcaccacg tgcaagatga gccagttccc     2220

tgaacggccg gccacggcgt taaccgcgct gctctgggct ctgcacgtct catctgctga     2280

ggcgcattac tgcatctttc atgcagaact tgctttccat gcctcacatc tccacatgtg     2340

tggggatatg tcctgagaaa tgcacggtta ggtgattctg tcgtgtgagc atccttgaat     2400

gtgcttacac agtcataaat ggtacagcct accacacgcc gaggctatac ggtatagccc     2460

attgctccta gactatacac ctgcacggca tgttcctgta gtgaaagctg taggcaatta     2520

taacgcaatg gataggttaa agacagagtt ttagtaaaaa tatggcataa taggccaggc     2580

gtggtggctc atgcctgtaa tcccagcact ttgggaggcc aaggcaggca gatcacaagg     2640

tcaggagttt gagaccagcc tggccaatat ggtgaaaccc agtctctact aaaaatacaa     2700

aaattagccg ggtgtggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag     2760

aagaatcatt tgaaccagga ggtggaggtt gcagtgagcc gagatcgcat cactgcactc     2820

cagcctgggc gacagagcaa gactgtctca aaaactaaaa caaaaaaaca ccaccaccac     2880

caccaatgtc tgattaaatc taagccacgg ttccattttg gggcaagggg cagggtgtgg     2940

gtgtggtgga cagagaacgg gctccagcca ccatcagctg cacgtcctgg tagcacctga     3000

gccattccca gtctcctgtg ctgggagatc atcatctaat cctgatgatg acgccctcct     3060

ctcagagctc gggggatgag ctgccaaaac ccatggaggt tcaaaacccg ggctctggag     3120

acagaagaca ctgggctcag agacatgggg ccactgtcca ggctttccct gggcctggac     3180

ctgggctcct tccactgtct gagcagggtc agcctgggct ggctgtgctg gttcaagaga     3240

tgagggagga ggacacagcg gttgccagga ccctgaggca ctggactggg cactgcccca     3300

aggggcagag gatggaaccc ggtgttgata ttgtgatgct gacccgtctg ctcacctgat     3360

ttgggtgctg aagggcagct gaccccccta atcttttata gacttgtgaa acgaaaataa     3420

ataaaagtca agctgggaac agcttagggc aaacctgcct cccattctat tcaaagccac     3480

ccctctgctc actgagatag atgcatgtct gatcacctca gttgggaaag gctaatcaga     3540

aactccaaag aatgcatctg ttcatctctc acccatctgt gacctggaag ccccctcccc     3600

acttcgagtc ttcctgcctt tgcttcaagt tttcccgcct ttccaaatgg aaccaaagta     3660

cttcttacat atagtgactc atgtctcaag tctccctaaa acgtataaaa ctaagctgtg     3720

ccccaaccac gctgaccatg tcatcaggac ctcctgaggc tgtgtcacgg cctgtgtcct     3780

caaccttggc aaaataaact ttctaaatta a                                    3811


<210>  116
<211>  418
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(418)
<223>  Siglec 16 Fragment (15-434)

<400>  116

Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val 
1               5                   10                  15      


Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg 
            20                  25                  30          


Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly 
        35                  40                  45              


Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser 
    50                  55                  60                  


Arg Glu Val Ala Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp 
65                  70                  75                  80  


Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu 
                85                  90                  95      


Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg 
            100                 105                 110         


His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr 
        115                 120                 125             


Gln Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro 
    130                 135                 140                 


Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala 
145                 150                 155                 160 


Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg 
                165                 170                 175     


Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln 
            180                 185                 190         


Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly 
        195                 200                 205             


Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Ser Leu Glu Leu 
    210                 215                 220                 


Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg 
225                 230                 235                 240 


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
                245                 250                 255     


Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr 
            260                 265                 270         


Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr 
        275                 280                 285             


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
    290                 295                 300                 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
305                 310                 315                 320 


Ala Asn Arg Thr Val Leu Glu Asn Leu Arg Asn Gly Thr Ser Leu Arg 
                325                 330                 335     


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser 
            340                 345                 350         


Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Glu Gln Thr Val Gly Pro 
        355                 360                 365             


Ser Gln Pro Ser Asp Pro Gly Val Leu Gln Leu Pro Arg Val Gln Met 
    370                 375                 380                 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
385                 390                 395                 400 


Gln Arg Val Ser Leu Ser Phe Ser Val His Cys Lys Ser Gly Pro Met 
                405                 410                 415     


Thr Gly 
        


<210>  117
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 16 Fragment (15-434) (G4S)2 / hIgG1 Fc N297G

<400>  117

Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val 
1               5                   10                  15      


Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg 
            20                  25                  30          


Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly 
        35                  40                  45              


Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser 
    50                  55                  60                  


Arg Glu Val Ala Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp 
65                  70                  75                  80  


Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu 
                85                  90                  95      


Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg 
            100                 105                 110         


His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr 
        115                 120                 125             


Gln Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro 
    130                 135                 140                 


Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala 
145                 150                 155                 160 


Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg 
                165                 170                 175     


Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln 
            180                 185                 190         


Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly 
        195                 200                 205             


Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Ser Leu Glu Leu 
    210                 215                 220                 


Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg 
225                 230                 235                 240 


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
                245                 250                 255     


Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr 
            260                 265                 270         


Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr 
        275                 280                 285             


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
    290                 295                 300                 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
305                 310                 315                 320 


Ala Asn Arg Thr Val Leu Glu Asn Leu Arg Asn Gly Thr Ser Leu Arg 
                325                 330                 335     


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser 
            340                 345                 350         


Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Glu Gln Thr Val Gly Pro 
        355                 360                 365             


Ser Gln Pro Ser Asp Pro Gly Val Leu Gln Leu Pro Arg Val Gln Met 
    370                 375                 380                 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
385                 390                 395                 400 


Gln Arg Val Ser Leu Ser Phe Ser Val His Cys Lys Ser Gly Pro Met 
                405                 410                 415     


Thr Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
            420                 425                 430         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        435                 440                 445             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    450                 455                 460                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
465                 470                 475                 480 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                485                 490                 495     


Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser 
            500                 505                 510         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        515                 520                 525             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    530                 535                 540                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
545                 550                 555                 560 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                565                 570                 575     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            580                 585                 590         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        595                 600                 605             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    610                 615                 620                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
625                 630                 635                 640 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655 


<210>  118
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 16 Fragment (15-434) (G4S)2 / hIgG1 Fc N297G

<400>  118
aacaaggacc ccagctacag cctgcaggtc cagagacagg tgccagtgcc tgaaggcctg       60

tgtgtgatcg tgtcctgcaa cctgagctac cccagagatg gctgggatga gagcacagcc      120

gcctacggct actggttcaa gggcagaaca agccccaaaa caggcgcccc agtggccacc      180

aacaaccagt ctagagaagt ggccatgagc acccgggaca gattccagtt gacaggcgat      240

cctggcaagg gcagctgtag cctggttatc agagatgccc agagagagga cgaggcctgg      300

tacttcttca gagtggaacg gggctctaga gtgcggcaca gctttctgag caacgcattc      360

ttcctgaaag tgacggccct gacacagaaa cccgacgtgt acatccccga gacactggaa      420

cctggccagc ctgtgacagt gatctgcgtg ttcaactggg ccttcaagaa gtgccccgct      480

cctagcttta gctggacagg cgctgctctg agccccagaa gaaccagacc tagcaccagc      540

cacttcagcg tgctgagctt caccccatct ccacaggacc acgacaccga tctgacctgc      600

cacgtggact tcagcagaaa gggcgtgtca gcccagagaa ccgtcagact gagagtggcc      660

agtctcgagc tgcagggcaa cgtgatctac ctggaagtgc agaagggcca gttcctgaga      720

ctgctgtgtg ccgccgattc tcagcctcct gctacactgt cttgggtgct gcaggacaga      780

gtgctgagca gcagtcatcc ttggggccct agaacactgg gcctcgaatt gcctggtgtc      840

aaggccggcg atagcggcag atacacatgc agagccgaga acagactggg cagccagcag      900

agagcactgg atctgagcgt gcagtaccct cctgagaacc tgagagtgat ggtgtcccag      960

gccaaccgga ccgtgctgga aaacctgaga aatggcacca gcctgagggt gctcgaggga     1020

cagtctctga gactcgtgtg tgtgacccac agcagccctc cagccagact ctcttggaca     1080

tggggagagc agacagtggg ccctagccag ccttctgatc ctggtgttct gcagctgccc     1140

cgggtgcaga tggaacacga aggcgagttt acctgtcacg ccagacatcc tctgggctcc     1200

cagagagtgt ctctgagctt tagcgtgcac tgcaagagcg gccctatgac aggaggcgga     1260

ggtggaagtg gcggaggcgg atccgacaaa actcacacat gcccaccgtg cccagcacct     1320

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1380

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1440

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1500

gaggagcagt acggtagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1560

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1620

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtcta caccctgccc     1680

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1740

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1800

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1860

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1920

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1965


<210>  119
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HSA-binding protein

<400>  119

Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly 
1               5                   10                  15      


Ile Thr Ser Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Gly Val Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
        35                  40                  45  


<210>  120
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / AS / hIgG1 
       Fc

<400>  120

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Ala Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  121
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / AS / hIgG1 
       Fc

<400>  121
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcagga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

agcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtaccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagctagcg acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210>  122
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX / EPKSS /
       hIgG1 Fc N297G

<400>  122

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Glu Pro Lys Ser Ser 
                325                 330                 335     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            340                 345                 350         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        355                 360                 365             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    370                 375                 380                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
385                 390                 395                 400 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
                405                 410                 415     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            420                 425                 430         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        435                 440                 445             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    450                 455                 460                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                485                 490                 495     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            500                 505                 510         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        515                 520                 525             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    530                 535                 540                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
545                 550                 555                 560 


Pro Gly Lys 
            


<210>  123
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX /  EPKSS 
       / hIgG1 Fc N297G

<400>  123
cagaccagca agctgctgac catgcagagc agcgtgaccg tgcaggaggg cctgtgcgtg       60

catgtgccct gcagcttcag ctaccccagc cacggctgga tctaccccgg tcccgtagtg      120

cacggctact ggttcaggga gggcgccaac accgaccagg acgctcccgt ggcaaccaac      180

aaccccgcca gggccgtgtg ggaggagacc agggacaggt tccacctgct gggcgacccc      240

cacaccaaga actgcaccct gagcatcagg gacgccagga ggagcgacgc cggcaggtac      300

ttcttcaaga tggagaaggg gtctatcaag tggaactaca agcaccaccg gctgagcgtg      360

aatgtgaccg ccctgaccca ccggcccaat atcctcatcc ccggcaccct ggagagcggc      420

agcccccaga atcttacctg cagcgtaccc tgggcctgcg agcagggcac ccctccaatg      480

atcagctgga tcggcaccag cgtgagcccc ctggacccta gtaccaccag gagcagcgtg      540

ctgaccctga tcccccagcc ccaggaccac ggaaccagcc tgacctgcca ggtgaccttc      600

cccggagcca gcgtaaccac caacaagacc gtgcacctga acgtgagcta cccaccccaa      660

aacctgacca tgaccgtgtt ccagggcgac ggcacggtga gcaccgtact gggcaacggc      720

agctctctga gcctgcccga gggccagagc ttgcggctgg tctgcgccgt ggatgctgtg      780

gacagcaacc ctcccgccag gctgagcctg agctggaggg gcctgaccct gtaccccagc      840

cagcccagca atcccggcgt gctggagctg ccctgggttc acctgaggga cgctgccgag      900

ttcacatgta gggcccagaa ccccctgggc tctcagcagg tgtacctgaa cgtgtctctt      960

cagagtaagg ccaccagcgg cgtgacccaa ggagagccca aatcttctga caaaactcac     1020

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     1080

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     1140

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1200

cataatgcca agacaaagcc gcgggaggag cagtacggta gcacgtaccg tgtggtcagc     1260

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1320

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1380

gaaccacagg tctacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1440

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1500

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1560

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1620

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1680

ccgggtaaa                                                             1689


<210>  124
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) / (G4S)2 / hIgG1 Fc

<400>  124

Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu Asn Thr Glu 
1               5                   10                  15      


Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val Pro Pro Glu 
            20                  25                  30          


Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr 
        35                  40                  45              


His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ala 
    50                  55                  60                  


Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala Ala Ala Arg 
65                  70                  75                  80  


Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg 
                85                  90                  95      


Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg 
            100                 105                 110         


Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val Glu Phe Ala 
        115                 120                 125             


Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu His 
    130                 135                 140                 


Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Ser Pro 
145                 150                 155                 160 


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
                165                 170                 175     


Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu Ala Ala Val 
            180                 185                 190         


Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala Glu Leu Pro 
        195                 200                 205             


Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu 
    210                 215                 220                 


Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Ser 
225                 230                 235                 240 


Gly Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  125
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 15 Fragment (20-263) / (G4S)2 / hIgG1 Fc

<400>  125
tttgtgcgga ccaagatcga caccaccgag aacctgctga acaccgaggt gcactctagc       60

cctgctcagc ggtggtctat gcaggtccca cctgaagtgt ctgccgaagc tggggatgct      120

gctgtgctgc cttgcacctt tacacaccct caccggcact acgatggccc tctgacagcc      180

atttggagag ccggcgaacc ttatgccgga ccacaggtgt tcagatgcgc tgccgctaga      240

ggctctgagc tgtgtcagac agccctgtct ctgcacggca gattcagact gctgggcaac      300

cccagaagaa acgacctgag cctgagagtg gaaagactgg ccctggccga cgacagacgg      360

tacttctgca gagtggaatt tgccggcgac gtgcacgaca gatacgagtc tagacacggc      420

gtgcggctgc acgttacagc cgctcctaga atcgtgaaca tcagcgtgct gccctctcca      480

gctcacgcct ttagagccct gtgtacagcc gaaggcgaac ctcctcctgc tcttgcttgg      540

agtggacccg ctctgggaaa ttctctggcc gccgtcagaa gccctagaga aggacacgga      600

cacctggtca cagccgaact gcctgctctg acacacgacg gcagatacac atgcacagcc      660

gccaatagcc tgggcagatc tgaggccagc gtgtacctgt tcagattcca tggcgccagc      720

ggcgcctcta caggcggagg tggaagtggc ggaggcggat ccgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtctaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  126
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) SAX / hIgG1 Fc N297G

<400>  126

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Lys Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  127
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) / hIgG1 Fc N297G

<400>  127

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            340                 345                 350         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly 
                405                 410                 415     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly Lys 
                565     


<210>  128
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 7 Fragment (19-357) SAX / hIgG1 Fc N297G

<400>  128

Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser Ser Val 
1               5                   10                  15      


Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe Ser Tyr 
            20                  25                  30          


Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr Trp Phe 
        35                  40                  45              


Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr Asn Asn 
    50                  55                  60                  


Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His Leu Leu 
65                  70                  75                  80  


Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg 
                85                  90                  95      


Met Ser Asp Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Asn Ile 
            100                 105                 110         


Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr Ala Leu 
        115                 120                 125             


Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys 
    130                 135                 140                 


Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr 
145                 150                 155                 160 


Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu His Pro 
                165                 170                 175     


Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln His 
            180                 185                 190         


His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala Gly Val 
        195                 200                 205             


Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro Gln Asn 
    210                 215                 220                 


Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr Ala Leu 
225                 230                 235                 240 


Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu Arg Leu 
                245                 250                 255     


Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp Thr Trp 
            260                 265                 270         


Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu Val Leu 
        275                 280                 285             


Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys Arg Ala 
    290                 295                 300                 


Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser Leu Gln 
305                 310                 315                 320 


Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu Leu Gly 
                325                 330                 335     


Ala Val Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            340                 345                 350         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        355                 360                 365             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    370                 375                 380                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
385                 390                 395                 400 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly 
                405                 410                 415     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            420                 425                 430         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        435                 440                 445             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    450                 455                 460                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
465                 470                 475                 480 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                485                 490                 495     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            500                 505                 510         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        515                 520                 525             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    530                 535                 540                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
545                 550                 555                 560 


Ser Leu Ser Pro Gly Lys 
                565     


<210>  129
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / hIgG1 Fc 
       N297G

<400>  129

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  130
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y, SAX / hIgG1 
       Fc N297G

<400>  130

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Lys Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  131
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-145) / hIgG1 Fc (w/ monovalent 
       mutations)

<400>  131

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Asn 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Asn Ser Thr Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys 
        355 


<210>  132
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (146-348) / hIgG1 Fc N297G

<400>  132

Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
1               5                   10                  15      


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
            20                  25                  30          


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
        35                  40                  45              


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
    50                  55                  60                  


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
65                  70                  75                  80  


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
                85                  90                  95      


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
        115                 120                 125             


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
    130                 135                 140                 


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
145                 150                 155                 160 


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
                165                 170                 175     


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
            180                 185                 190         


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
        195                 200                 205             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    210                 215                 220                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
225                 230                 235                 240 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                245                 250                 255     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            260                 265                 270         


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
        275                 280                 285             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    290                 295                 300                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
305                 310                 315                 320 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                325                 330                 335     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            340                 345                 350         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        355                 360                 365             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    370                 375                 380                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
385                 390                 395                 400 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                405                 410                 415     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430 


<210>  133
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K131Q / hIgG1 Fc N297G

<400>  133

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Gln His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  134
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) K100E, A315E / hIgG1 Fc 
       N297G

<400>  134

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Glu Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Glu Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  135
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 9 Fragment (18-348) C158S, C295Y / AS / hIgG1 
       Fc

<400>  135

Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly 
            20                  25                  30          


Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly 
        35                  40                  45              


Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg 
    50                  55                  60                  


Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro 
65                  70                  75                  80  


His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp 
                85                  90                  95      


Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn 
            100                 105                 110         


Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg 
        115                 120                 125             


Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Ser Pro Gln Asn 
    130                 135                 140                 


Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met 
145                 150                 155                 160 


Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr 
                165                 170                 175     


Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr 
            180                 185                 190         


Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn 
        195                 200                 205             


Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met 
    210                 215                 220                 


Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly 
225                 230                 235                 240 


Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala 
                245                 250                 255     


Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp 
            260                 265                 270         


Arg Gly Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Gly Val Leu 
        275                 280                 285             


Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg 
    290                 295                 300                 


Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu 
305                 310                 315                 320 


Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  136
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  N-terminal signal sequence

<400>  136

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  137
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  C terminal lysosomal signal motif

<400>  137

Tyr Gly Thr Leu 
1               


<210>  138
<211>  481
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(481)
<223>  Siglec 16 FL (uniprot A6NMB1)

<400>  138

Met Leu Leu Leu Pro Leu Leu Leu Pro Val Leu Gly Ala Gly Ser Leu 
1               5                   10                  15      


Asn Lys Asp Pro Ser Tyr Ser Leu Gln Val Gln Arg Gln Val Pro Val 
            20                  25                  30          


Pro Glu Gly Leu Cys Val Ile Val Ser Cys Asn Leu Ser Tyr Pro Arg 
        35                  40                  45              


Asp Gly Trp Asp Glu Ser Thr Ala Ala Tyr Gly Tyr Trp Phe Lys Gly 
    50                  55                  60                  


Arg Thr Ser Pro Lys Thr Gly Ala Pro Val Ala Thr Asn Asn Gln Ser 
65                  70                  75                  80  


Arg Glu Val Ala Met Ser Thr Arg Asp Arg Phe Gln Leu Thr Gly Asp 
                85                  90                  95      


Pro Gly Lys Gly Ser Cys Ser Leu Val Ile Arg Asp Ala Gln Arg Glu 
            100                 105                 110         


Asp Glu Ala Trp Tyr Phe Phe Arg Val Glu Arg Gly Ser Arg Val Arg 
        115                 120                 125             


His Ser Phe Leu Ser Asn Ala Phe Phe Leu Lys Val Thr Ala Leu Thr 
    130                 135                 140                 


Gln Lys Pro Asp Val Tyr Ile Pro Glu Thr Leu Glu Pro Gly Gln Pro 
145                 150                 155                 160 


Val Thr Val Ile Cys Val Phe Asn Trp Ala Phe Lys Lys Cys Pro Ala 
                165                 170                 175     


Pro Ser Phe Ser Trp Thr Gly Ala Ala Leu Ser Pro Arg Arg Thr Arg 
            180                 185                 190         


Pro Ser Thr Ser His Phe Ser Val Leu Ser Phe Thr Pro Ser Pro Gln 
        195                 200                 205             


Asp His Asp Thr Asp Leu Thr Cys His Val Asp Phe Ser Arg Lys Gly 
    210                 215                 220                 


Val Ser Ala Gln Arg Thr Val Arg Leu Arg Val Ala Ser Leu Glu Leu 
225                 230                 235                 240 


Gln Gly Asn Val Ile Tyr Leu Glu Val Gln Lys Gly Gln Phe Leu Arg 
                245                 250                 255     


Leu Leu Cys Ala Ala Asp Ser Gln Pro Pro Ala Thr Leu Ser Trp Val 
            260                 265                 270         


Leu Gln Asp Arg Val Leu Ser Ser Ser His Pro Trp Gly Pro Arg Thr 
        275                 280                 285             


Leu Gly Leu Glu Leu Pro Gly Val Lys Ala Gly Asp Ser Gly Arg Tyr 
    290                 295                 300                 


Thr Cys Arg Ala Glu Asn Arg Leu Gly Ser Gln Gln Arg Ala Leu Asp 
305                 310                 315                 320 


Leu Ser Val Gln Tyr Pro Pro Glu Asn Leu Arg Val Met Val Ser Gln 
                325                 330                 335     


Ala Asn Arg Thr Val Leu Glu Asn Leu Arg Asn Gly Thr Ser Leu Arg 
            340                 345                 350         


Val Leu Glu Gly Gln Ser Leu Arg Leu Val Cys Val Thr His Ser Ser 
        355                 360                 365             


Pro Pro Ala Arg Leu Ser Trp Thr Trp Gly Glu Gln Thr Val Gly Pro 
    370                 375                 380                 


Ser Gln Pro Ser Asp Pro Gly Val Leu Gln Leu Pro Arg Val Gln Met 
385                 390                 395                 400 


Glu His Glu Gly Glu Phe Thr Cys His Ala Arg His Pro Leu Gly Ser 
                405                 410                 415     


Gln Arg Val Ser Leu Ser Phe Ser Val His Cys Lys Ser Gly Pro Met 
            420                 425                 430         


Thr Gly Val Val Leu Val Ala Val Gly Glu Val Ala Met Lys Ile Leu 
        435                 440                 445             


Leu Leu Cys Leu Cys Leu Ile Leu Leu Arg Val Arg Ser Cys Arg Arg 
    450                 455                 460                 


Lys Ala Ala Arg Ala Ala Leu Gly Met Glu Ala Ala Asp Ala Val Thr 
465                 470                 475                 480 


Asp 
    


<210>  139
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) / AS / hIgG1 Fc N297G

<400>  139

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  140
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) / AS / hIgG1 Fc

<400>  140
gatcccaatt tctggctgca agtgcaagag tccgtgaccg tgcaagaggg cctgtgtgtg       60

ctggtgccct gcaccttctt tcaccccatt ccttactacg acaagaacag ccctgtgcac      120

ggctactggt ttagagaggg cgccatcatc agcagagata gccctgtggc caccaacaag      180

ctggaccaag aggtgcaaga agagacacag ggcagattca gactgctggg cgaccccagc      240

agaaacaact gcagcctgtc tatcgtggac gccaggcgga gagacaacgg cagctacttc      300

ttcaggatgg aacggggcag caccaagtac agctacaaga gccctcagct gtccgtgcac      360

gtgaccgacc tgacacacag acccaagatt ctgatccccg gcacactgga acctggccac      420

agcaagaatc tgacctgctc cgtgtcctgg gcctgcgaac agggaacccc tcctatcttt      480

agctggctga gcgccgctcc tacatctctg ggccctagaa caacacacag cagcgtgctg      540

atcatcaccc ctagacctca ggaccacggc accaacctga cctgccaagt gaaatttgct      600

ggcgctggcg tgaccaccga gagaaccatc cagctgaacg tgacctacgt gccacagaac      660

cctaccaccg gcatctttcc aggcgacggc tctggcaagc aagaaacaag agctggcgtg      720

gtgcacgcta gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaa                                  1413


<210>  141
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) / AS / hIgG1 Fc N297G

<400>  141

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
    210                 215                 220                 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
225                 230                 235                 240 


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
                245                 250                 255     


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
            260                 265                 270         


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
        275                 280                 285             


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
    290                 295                 300                 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
305                 310                 315                 320 


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
                325                 330                 335     


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
            340                 345                 350         


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
        355                 360                 365             


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
    370                 375                 380                 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
385                 390                 395                 400 


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
                405                 410                 415     


Gly Thr Gly Val Val Pro Ala Ala Leu Ala Ser Asp Lys Thr His Thr 
            420                 425                 430         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        435                 440                 445             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    450                 455                 460                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
465                 470                 475                 480 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                485                 490                 495     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            500                 505                 510         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        515                 520                 525             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    530                 535                 540                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                565                 570                 575     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            580                 585                 590         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        595                 600                 605             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    610                 615                 620                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
625                 630                 635                 640 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 


<210>  142
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) / AS / hIgG1 Fc N297G

<400>  142
gagaagcccg tgtatgagct gcaggtccag aaaagcgtga ccgtgcaaga gggcctgtgt       60

gtgctggtgc cttgcagctt tagctaccct tggcggagct ggtacagcag ccctcctctg      120

tacgtgtact ggttcagaga tggcgagatc ccctactacg ccgaggtggt ggccacaaac      180

aaccccgaca gaagagtgaa gcccgagaca cagggcagat tcagactgct gggcgacgtg      240

cagaagaaga actgcagcct gagcatcggc gacgcccgga tggaagatac cggcagctac      300

ttcttcagag tggaacgcgg cagggacgtg aagtacagct accagcagaa caagctgaac      360

ctggaagtga cagccctgat cgagaagcct gacatccact ttctggaacc cctggaaagc      420

ggcagaccca ccagactgtc ttgtagcctg cctggcagct gtgaagctgg ccctccactg      480

acctttagct ggaccggcaa tgccctgtct cctctggacc ctgagacaac cagaagcagc      540

gagctgaccc tgacacctag acctgaggac cacggcacca atctgacctg ccagatgaag      600

aggcagggcg cccaagtgac caccgagaga acagtgcagc tgaacgtgtc ctacgctccc      660

cagaccatca ccatcttccg gaacggaatc gccctggaaa tcctgcagaa caccagctac      720

ctgcctgtgc tggaaggcca ggctctgaga ctgctgtgtg acgcccctag caatcctcct      780

gctcacctga gctggtttca gggcagccca gctctgaacg ccacacctat cagcaacacc      840

ggcatcctgg aactgagaag agtgcggagc gctgaggaag gcggcttcac ttgtagagcc      900

cagcatcctc tgggctttct gcagatcttc ctgaacctga gcgtgtacag cctgccacag      960

ctgctgggac ctagctgttc ttgggaagcc gagggcctgc actgccggtg tagctttaga     1020

gctagacccg ctcctagcct gtgttggcgg ctggaagaga aacctctgga aggcaatagc     1080

agccagggca gcttcaaagt gaacagcagc tctgccggac cttgggccaa tagctctctg     1140

attctgcacg gcggcctgag cagcgatctg aaggtgtcat gcaaggcctg gaacatctac     1200

ggcagccagt ctggctctgt gctgctgctt cagggaagaa gcaatctcgg cacaggcgtg     1260

gtgcctgctg ctctggctag cgacaaaact cacacatgcc caccgtgccc agcacctgaa     1320

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1380

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1440

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1500

gagcagtacg gtagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1560

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1620

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtctacac cctgccccca     1680

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1740

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1800

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1860

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1920

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1962


<210>  143
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) SAX / AS / hIgG1 Fc N297G

<400>  143

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Ala Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
    210                 215                 220                 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
225                 230                 235                 240 


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
                245                 250                 255     


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
            260                 265                 270         


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
        275                 280                 285             


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
    290                 295                 300                 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
305                 310                 315                 320 


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
                325                 330                 335     


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
            340                 345                 350         


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
        355                 360                 365             


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
    370                 375                 380                 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
385                 390                 395                 400 


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
                405                 410                 415     


Gly Thr Gly Val Val Pro Ala Ala Leu Ala Ser Asp Lys Thr His Thr 
            420                 425                 430         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        435                 440                 445             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    450                 455                 460                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
465                 470                 475                 480 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                485                 490                 495     


Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val 
            500                 505                 510         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        515                 520                 525             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    530                 535                 540                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                565                 570                 575     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            580                 585                 590         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        595                 600                 605             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    610                 615                 620                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
625                 630                 635                 640 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 


<210>  144
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) SAX / AS / hIgG1 Fc N297G

<400>  144
gagaagcccg tgtatgagct gcaggtccag aaaagcgtga ccgtgcaaga gggcctgtgt       60

gtgctggtgc cttgcagctt tagctaccct tggcggagct ggtacagcag ccctcctctg      120

tacgtgtact ggttcagaga tggcgagatc ccctactacg ccgaggtggt ggccacaaac      180

aaccccgaca gaagagtgaa gcccgagaca cagggcagat tcagactgct gggcgacgtg      240

cagaagaaga actgcagcct gagcatcggc gacgcccgga tggaagatac cggcagctac      300

ttcttcgccg tggaacgcgg cagggacgtg aagtacagct accagcagaa caagctgaac      360

ctggaagtga cagccctgat cgagaagcct gacatccact ttctggaacc cctggaaagc      420

ggcagaccca ccagactgtc ttgtagcctg cctggcagct gtgaagctgg ccctccactg      480

acctttagct ggaccggcaa tgccctgtct cctctggacc ctgagacaac cagaagcagc      540

gagctgaccc tgacacctag acctgaggac cacggcacca atctgacctg ccagatgaag      600

aggcagggcg cccaagtgac caccgagaga acagtgcagc tgaacgtgtc ctacgctccc      660

cagaccatca ccatcttccg gaacggaatc gccctggaaa tcctgcagaa caccagctac      720

ctgcctgtgc tggaaggcca ggctctgaga ctgctgtgtg acgcccctag caatcctcct      780

gctcacctga gctggtttca gggcagccca gctctgaacg ccacacctat cagcaacacc      840

ggcatcctgg aactgagaag agtgcggagc gctgaggaag gcggcttcac ttgtagagcc      900

cagcatcctc tgggctttct gcagatcttc ctgaacctga gcgtgtacag cctgccacag      960

ctgctgggac ctagctgttc ttgggaagcc gagggcctgc actgccggtg tagctttaga     1020

gctagacccg ctcctagcct gtgttggcgg ctggaagaga aacctctgga aggcaatagc     1080

agccagggca gcttcaaagt gaacagcagc tctgccggac cttgggccaa tagctctctg     1140

attctgcacg gcggcctgag cagcgatctg aaggtgtcat gcaaggcctg gaacatctac     1200

ggcagccagt ctggctctgt gctgctgctt cagggaagaa gcaatctcgg cacaggcgtg     1260

gtgcctgctg ctctggctag cgacaaaact cacacatgcc caccgtgccc agcacctgaa     1320

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1380

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1440

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1500

gagcagtacg gtagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1560

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1620

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtctacac cctgccccca     1680

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1740

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1800

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1860

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1920

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1962


<210>  145
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) / AS / hIgG1 Fc N297G

<400>  145

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
    210                 215                 220                 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
225                 230                 235                 240 


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
                245                 250                 255     


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
            260                 265                 270         


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
        275                 280                 285             


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
    290                 295                 300                 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
305                 310                 315                 320 


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
                325                 330                 335     


Ser Trp Pro Leu Val Leu Ala Ser Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        355                 360                 365             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    370                 375                 380                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
385                 390                 395                 400 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                405                 410                 415     


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            420                 425                 430         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        435                 440                 445             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    450                 455                 460                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
465                 470                 475                 480 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                485                 490                 495     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            500                 505                 510         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        515                 520                 525             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    530                 535                 540                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
545                 550                 555                 560 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570     


<210>  146
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) / AS / hIgG1 Fc N297G

<400>  146
gagaagcccg tgtatgagct gcaggtccag aaaagcgtga ccgtgcaaga gggcctgtgt       60

gtgctggtgc cttgcagctt tagctaccct tggcggagct ggtacagcag ccctcctctg      120

tacgtgtact ggttcagaga tggcgagatc ccctactacg ccgaggtggt ggccacaaac      180

aaccccgaca gaagagtgaa gcccgagaca cagggcagat tcagactgct gggcgacgtg      240

cagaagaaga actgcagcct gagcatcggc gacgcccgga tggaagatac cggcagctac      300

ttcttcagag tggaacgcgg cagggacgtg aagtacagct accagcagaa caagctgaac      360

ctggaagtga cagccctgat cgagaagcct gacatccact ttctggaacc cctggaaagc      420

ggcagaccca ccagactgtc ttgtagcctg cctggcagct gtgaagctgg ccctccactg      480

acctttagct ggaccggcaa tgccctgtct cctctggacc ctgagacaac cagaagcagc      540

gagctgaccc tgacacctag acctgaggac cacggcacca acctgacctg ccaagtgaaa      600

agacagggcg cccaagtgac caccgagaga acagtgcagc tgaacgtgtc ctacgctccc      660

cagaacctgg ccatcagcat ctttttcaga aacggcaccg gcacagccct gcggatcctg      720

tctaatggca tgagcgtgcc catccaagag ggacagtctc tgttcctggc ctgcaccgtg      780

gactctaatc ctccagctag cctgagctgg tttagagagg gcaaagccct gaatcctagc      840

cagaccagca tgagcggcac cctggaactg cctaatatcg gcgctagaga aggcggcgag      900

ttcacctgta gagtgcagca ccctctgggc agccagcacc tgagctttat cctgagcgtg      960

cagagaagca gcagcagctg catctgcgtg accgagaaac agcaaggcag ctggcctctg     1020

gttctggcta gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1080

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1140

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1200

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1260

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1320

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1380

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     1440

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1500

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1560

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1620

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1680

acgcagaaga gcctctccct gtctccgggt aaa                                  1713


<210>  147
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) SAX / AS / hIgG1 Fc N297G

<400>  147

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Ala Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
    210                 215                 220                 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
225                 230                 235                 240 


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
                245                 250                 255     


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
            260                 265                 270         


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
        275                 280                 285             


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
    290                 295                 300                 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
305                 310                 315                 320 


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
                325                 330                 335     


Ser Trp Pro Leu Val Leu Ala Ser Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        355                 360                 365             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    370                 375                 380                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
385                 390                 395                 400 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                405                 410                 415     


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            420                 425                 430         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        435                 440                 445             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    450                 455                 460                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
465                 470                 475                 480 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                485                 490                 495     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            500                 505                 510         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        515                 520                 525             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    530                 535                 540                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
545                 550                 555                 560 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570     


<210>  148
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) SAX / AS / hIgG1 Fc N297G

<400>  148
gagaagcccg tgtatgagct gcaggtccag aaaagcgtga ccgtgcaaga gggcctgtgt       60

gtgctggtgc cttgcagctt tagctaccct tggcggagct ggtacagcag ccctcctctg      120

tacgtgtact ggttcagaga tggcgagatc ccctactacg ccgaggtggt ggccacaaac      180

aaccccgaca gaagagtgaa gcccgagaca cagggcagat tcagactgct gggcgacgtg      240

cagaagaaga actgcagcct gagcatcggc gacgcccgga tggaagatac cggcagctac      300

ttcttcgccg tggaacgcgg cagggacgtg aagtacagct accagcagaa caagctgaac      360

ctggaagtga cagccctgat cgagaagcct gacatccact ttctggaacc cctggaaagc      420

ggcagaccca ccagactgtc ttgtagcctg cctggcagct gtgaagctgg ccctccactg      480

acctttagct ggaccggcaa tgccctgtct cctctggacc ctgagacaac cagaagcagc      540

gagctgaccc tgacacctag acctgaggac cacggcacca acctgacctg ccaagtgaaa      600

agacagggcg cccaagtgac caccgagaga acagtgcagc tgaacgtgtc ctacgctccc      660

cagaacctgg ccatcagcat ctttttcaga aacggcaccg gcacagccct gcggatcctg      720

tctaatggca tgagcgtgcc catccaagag ggacagtctc tgttcctggc ctgcaccgtg      780

gactctaatc ctccagctag cctgagctgg tttagagagg gcaaagccct gaatcctagc      840

cagaccagca tgagcggcac cctggaactg cctaatatcg gcgctagaga aggcggcgag      900

ttcacctgta gagtgcagca ccctctgggc agccagcacc tgagctttat cctgagcgtg      960

cagagaagca gcagcagctg catctgcgtg accgagaaac agcaaggcag ctggcctctg     1020

gttctggcta gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1080

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1140

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1200

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1260

ggtagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1320

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1380

tccaaagcca aagggcagcc ccgagaacca caggtctaca ccctgccccc atcccgggag     1440

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1500

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1560

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     1620

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1680

acgcagaaga gcctctccct gtctccgggt aaa                                  1713


<210>  149
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) / hIgG1 Fc N297G

<400>  149

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
    210                 215                 220                 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
225                 230                 235                 240 


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
                245                 250                 255     


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
            260                 265                 270         


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
        275                 280                 285             


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
    290                 295                 300                 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
305                 310                 315                 320 


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
                325                 330                 335     


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
            340                 345                 350         


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
        355                 360                 365             


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
    370                 375                 380                 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
385                 390                 395                 400 


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
                405                 410                 415     


Gly Thr Gly Val Val Pro Ala Ala Leu Asp Lys Thr His Thr Cys Pro 
            420                 425                 430         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        435                 440                 445             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    450                 455                 460                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
465                 470                 475                 480 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                485                 490                 495     


Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            500                 505                 510         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        515                 520                 525             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    530                 535                 540                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
545                 550                 555                 560 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                565                 570                 575     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            580                 585                 590         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        595                 600                 605             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    610                 615                 620                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
625                 630                 635                 640 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650         


<210>  150
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 5 Fragment (17-441) SAX / hIgG1 Fc N297G

<400>  150

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Ala Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
    210                 215                 220                 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
225                 230                 235                 240 


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
                245                 250                 255     


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
            260                 265                 270         


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
        275                 280                 285             


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
    290                 295                 300                 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
305                 310                 315                 320 


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
                325                 330                 335     


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
            340                 345                 350         


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
        355                 360                 365             


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
    370                 375                 380                 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
385                 390                 395                 400 


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
                405                 410                 415     


Gly Thr Gly Val Val Pro Ala Ala Leu Asp Lys Thr His Thr Cys Pro 
            420                 425                 430         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        435                 440                 445             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    450                 455                 460                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
465                 470                 475                 480 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                485                 490                 495     


Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            500                 505                 510         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        515                 520                 525             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    530                 535                 540                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
545                 550                 555                 560 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                565                 570                 575     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            580                 585                 590         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        595                 600                 605             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    610                 615                 620                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
625                 630                 635                 640 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650         


<210>  151
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) SAX / hIgG1 Fc N297G

<400>  151

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Ala Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
    210                 215                 220                 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
225                 230                 235                 240 


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
                245                 250                 255     


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
            260                 265                 270         


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
        275                 280                 285             


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
    290                 295                 300                 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
305                 310                 315                 320 


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
                325                 330                 335     


Ser Trp Pro Leu Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            340                 345                 350         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        355                 360                 365             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    370                 375                 380                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
385                 390                 395                 400 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                405                 410                 415     


Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            420                 425                 430         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        435                 440                 445             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    450                 455                 460                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
465                 470                 475                 480 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                485                 490                 495     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            500                 505                 510         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        515                 520                 525             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    530                 535                 540                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
545                 550                 555                 560 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 


<210>  152
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  N-terminal signal sequence

<400>  152

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  153
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  N-terminal signal sequence

<400>  153

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  154
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 3 Fragment (18-259) / hIgG1 Fc N297G

<400>  154

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  155
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 14 Fragment (17-358) / hIgG1 Fc N297G

<400>  155

Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
            20                  25                  30          


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
        35                  40                  45              


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
    50                  55                  60                  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
65                  70                  75                  80  


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
                85                  90                  95      


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
            100                 105                 110         


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
        115                 120                 125             


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
    130                 135                 140                 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
145                 150                 155                 160 


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
                165                 170                 175     


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
            180                 185                 190         


Thr Asn Leu Thr Cys Gln Val Lys Arg Gln Gly Ala Gln Val Thr Thr 
        195                 200                 205             


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Asn Leu Ala 
    210                 215                 220                 


Ile Ser Ile Phe Phe Arg Asn Gly Thr Gly Thr Ala Leu Arg Ile Leu 
225                 230                 235                 240 


Ser Asn Gly Met Ser Val Pro Ile Gln Glu Gly Gln Ser Leu Phe Leu 
                245                 250                 255     


Ala Cys Thr Val Asp Ser Asn Pro Pro Ala Ser Leu Ser Trp Phe Arg 
            260                 265                 270         


Glu Gly Lys Ala Leu Asn Pro Ser Gln Thr Ser Met Ser Gly Thr Leu 
        275                 280                 285             


Glu Leu Pro Asn Ile Gly Ala Arg Glu Gly Gly Glu Phe Thr Cys Arg 
    290                 295                 300                 


Val Gln His Pro Leu Gly Ser Gln His Leu Ser Phe Ile Leu Ser Val 
305                 310                 315                 320 


Gln Arg Ser Ser Ser Ser Cys Ile Cys Val Thr Glu Lys Gln Gln Gly 
                325                 330                 335     


Ser Trp Pro Leu Val Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            340                 345                 350         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        355                 360                 365             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    370                 375                 380                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
385                 390                 395                 400 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                405                 410                 415     


Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            420                 425                 430         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        435                 440                 445             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    450                 455                 460                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
465                 470                 475                 480 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                485                 490                 495     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            500                 505                 510         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        515                 520                 525             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    530                 535                 540                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
545                 550                 555                 560 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 


<210>  156
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX

<400>  156

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Lys 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val 
    


<210>  157
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX

<400>  157
caagagcggc ggtttcagct ggaaggacct gagagcctga cagtgcaaga gggcctgtgt       60

gtgctggtgc cttgtagact gcctaccaca ctgcccgcca gctactacgg ctacggctat      120

tggtttctgg aaggcgccga tgtgcccgtg gccaccaatg atcctgacga ggaagtgcaa      180

gaagagacac ggggcagatt ccatctgctg tgggacccca gacggaagaa ctgcagcctg      240

agcatcagag atgccagaag gcgggataac gccgcctact tcttcaagct gaagtccaag      300

tggatgaagt acggctacac cagcagcaag ctgagcgtca gagtgatggc cctgacacac      360

agacccaaca tcagcatccc cggcacactg gaaagcggac accctagcaa tctgacctgc      420

agcgtgccat gggtttgcga gcagggaacc cctcctatct tctcctggat gtctgccgct      480

cctacctctc tgggccctag aacaacacag agcagcgtgc tgaccatcac acccagacct      540

caggaccaca gcaccaacct gacctgccaa gtgacctttc ctggcgctgg cgtgaccatg      600

gaaagaacca tccagctcaa cgtgtcctac gctccccaga aggtggccat cagcattttc      660

cagggcaaca gcgccgcctt caagatcctg cagaatacca gcagcctgcc tgtgctggaa      720

ggccaggctc tgagactgct gtgtgacgcc gatggcaatc ctcctgctca cctgagctgg      780

ttccagggct tcccagctct gaacgccaca cctatcagca acaccggcgt gctggaactg      840

cctcaagtgg gatctgccga ggaaggcgac ttcacctgta gagcccaaca tcctctgggc      900

agcctgcaga tctccctgag cctgtttgtg cactggaagc ccgaaggcag agctggcgga      960

gtg                                                                    963


<210>  158
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX / EPKSS / hIgG1 Fc 
       N297G

<400>  158

Gln Glu Arg Arg Phe Gln Leu Glu Gly Pro Glu Ser Leu Thr Val Gln 
1               5                   10                  15      


Glu Gly Leu Cys Val Leu Val Pro Cys Arg Leu Pro Thr Thr Leu Pro 
            20                  25                  30          


Ala Ser Tyr Tyr Gly Tyr Gly Tyr Trp Phe Leu Glu Gly Ala Asp Val 
        35                  40                  45              


Pro Val Ala Thr Asn Asp Pro Asp Glu Glu Val Gln Glu Glu Thr Arg 
    50                  55                  60                  


Gly Arg Phe His Leu Leu Trp Asp Pro Arg Arg Lys Asn Cys Ser Leu 
65                  70                  75                  80  


Ser Ile Arg Asp Ala Arg Arg Arg Asp Asn Ala Ala Tyr Phe Phe Lys 
                85                  90                  95      


Leu Lys Ser Lys Trp Met Lys Tyr Gly Tyr Thr Ser Ser Lys Leu Ser 
            100                 105                 110         


Val Arg Val Met Ala Leu Thr His Arg Pro Asn Ile Ser Ile Pro Gly 
        115                 120                 125             


Thr Leu Glu Ser Gly His Pro Ser Asn Leu Thr Cys Ser Val Pro Trp 
    130                 135                 140                 


Val Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Met Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Ser Leu Gly Pro Arg Thr Thr Gln Ser Ser Val Leu Thr Ile 
                165                 170                 175     


Thr Pro Arg Pro Gln Asp His Ser Thr Asn Leu Thr Cys Gln Val Thr 
            180                 185                 190         


Phe Pro Gly Ala Gly Val Thr Met Glu Arg Thr Ile Gln Leu Asn Val 
        195                 200                 205             


Ser Tyr Ala Pro Gln Lys Val Ala Ile Ser Ile Phe Gln Gly Asn Ser 
    210                 215                 220                 


Ala Ala Phe Lys Ile Leu Gln Asn Thr Ser Ser Leu Pro Val Leu Glu 
225                 230                 235                 240 


Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Asp Gly Asn Pro Pro Ala 
                245                 250                 255     


His Leu Ser Trp Phe Gln Gly Phe Pro Ala Leu Asn Ala Thr Pro Ile 
            260                 265                 270         


Ser Asn Thr Gly Val Leu Glu Leu Pro Gln Val Gly Ser Ala Glu Glu 
        275                 280                 285             


Gly Asp Phe Thr Cys Arg Ala Gln His Pro Leu Gly Ser Leu Gln Ile 
    290                 295                 300                 


Ser Leu Ser Leu Phe Val His Trp Lys Pro Glu Gly Arg Ala Gly Gly 
305                 310                 315                 320 


Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                325                 330                 335     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            340                 345                 350         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        355                 360                 365             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    370                 375                 380                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
385                 390                 395                 400 


Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                405                 410                 415     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            420                 425                 430         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        435                 440                 445             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    450                 455                 460                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
465                 470                 475                 480 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                485                 490                 495     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            500                 505                 510         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        515                 520                 525             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    530                 535                 540                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550             


<210>  159
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Siglec 6 Fragment (27-347) SAX / EPKSS / hIgG1 Fc 
       N297G

<400>  159
caagagcggc ggtttcagct ggaaggacct gagagcctga cagtgcaaga gggcctgtgt       60

gtgctggtgc cttgtagact gcctaccaca ctgcccgcca gctactacgg ctacggctat      120

tggtttctgg aaggcgccga tgtgcccgtg gccaccaatg atcctgacga ggaagtgcaa      180

gaagagacac ggggcagatt ccatctgctg tgggacccca gacggaagaa ctgcagcctg      240

agcatcagag atgccagaag gcgggataac gccgcctact tcttcaagct gaagtccaag      300

tggatgaagt acggctacac cagcagcaag ctgagcgtca gagtgatggc cctgacacac      360

agacccaaca tcagcatccc cggcacactg gaaagcggac accctagcaa tctgacctgc      420

agcgtgccat gggtttgcga gcagggaacc cctcctatct tctcctggat gtctgccgct      480

cctacctctc tgggccctag aacaacacag agcagcgtgc tgaccatcac acccagacct      540

caggaccaca gcaccaacct gacctgccaa gtgacctttc ctggcgctgg cgtgaccatg      600

gaaagaacca tccagctcaa cgtgtcctac gctccccaga aggtggccat cagcattttc      660

cagggcaaca gcgccgcctt caagatcctg cagaatacca gcagcctgcc tgtgctggaa      720

ggccaggctc tgagactgct gtgtgacgcc gatggcaatc ctcctgctca cctgagctgg      780

ttccagggct tcccagctct gaacgccaca cctatcagca acaccggcgt gctggaactg      840

cctcaagtgg gatctgccga ggaaggcgac ttcacctgta gagcccaaca tcctctgggc      900

agcctgcaga tctccctgag cctgtttgtg cactggaagc ccgaaggcag agctggcgga      960

gtggagccca aatcttctga caaaactcac acatgcccac cgtgcccagc acctgaactc     1020

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1080

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1140

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1200

cagtacggta gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1260

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1320

accatctcca aagccaaagg gcagccccga gaaccacagg tctacaccct gcccccatcc     1380

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1440

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1500

cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag     1560

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1620

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1659


<210>  160
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc N297G with N-terminal EPKSS included.

<400>  160

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  161
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hIgG1 Fc N297G with N-terminal EPKSS included.

<400>  161
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacggtagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtct acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


