                         SEQUENCE LISTING

<110>  VisionTech Bio Pty Ltd
 
<120>  Biomarkers for colorectal cancer

<130>  532236PCT

<150>  AU 2021901164
<151>  2021-04-20

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  2
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  3
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  4
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  5
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg 
385                 390                 395                 400 


Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  6
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg 
385                 390                 395                 400 


Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser 
                405                 410                 415     


Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr 
            420                 425                 430         


Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  7
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  8
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  9
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  10
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  11
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  12
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  13
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  14
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  15
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  16
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
1               5                   10                  15      


Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala Ser 
            20                  25                  30          


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
        35                  40                  45              


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys 
    50                  55                  60                  


Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe 
65                  70                  75                  80  


Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln 
                85                  90                  95      


Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg 
            100                 105                 110         


Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys 
        115                 120                 125             


Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His Gly 
    130                 135                 140                 


Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
145                 150                 155 


<210>  17
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  18
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Phe Thr Thr Arg Ser Thr Phe Ser Thr Asn Tyr Arg Ser Leu Gly 
1               5                   10                  15      


Ser Val Gln Ala Pro Ser Tyr Gly Ala Arg Pro Val Ser Ser Ala Ala 
            20                  25                  30          


Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val Ser 
        35                  40                  45              


Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Gly Leu Ala Thr 
    50                  55                  60                  


Gly Ile Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Glu Lys 
65                  70                  75                  80  


Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Arg 
                85                  90                  95      


Val Arg Ser Leu Glu Thr Glu Asn Arg Arg Leu Glu Ser Lys Ile Arg 
            100                 105                 110         


Glu His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp Trp Ser His Tyr 
        115                 120                 125             


Phe Lys Ile Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr Val 
    130                 135                 140                 


Asp Asn Ala Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu Ala Ala 
145                 150                 155                 160 


Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Ala Met Arg Gln Ser 
                165                 170                 175     


Val Glu Asn Asp Ile His Gly Leu Arg Lys Val Ile Asp Asp Thr Asn 
            180                 185                 190         


Ile Thr Arg Leu Gln Leu Glu Thr Glu Ile Glu Ala Leu Lys Glu Glu 
        195                 200                 205             


Leu Leu Phe Met Lys Lys Asn His Glu Glu Glu Val Lys Gly Leu Gln 
    210                 215                 220                 


Ala Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala Pro Lys 
225                 230                 235                 240 


Ser Gln Asp Leu Ala Lys Ile Met Ala Asp Ile Arg Ala Gln Tyr Asp 
                245                 250                 255     


Glu Leu Ala Arg Lys Asn Arg Glu Glu Leu Asp Lys Tyr Trp Ser Gln 
            260                 265                 270         


Gln Ile Glu Glu Ser Thr Thr Val Val Thr Thr Gln Ser Ala Glu Val 
        275                 280                 285             


Gly Ala Ala Glu Thr Thr Leu Thr Glu Leu Arg Arg Thr Val Gln Ser 
    290                 295                 300                 


Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu Lys Ala Ser Leu Glu 
305                 310                 315                 320 


Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Ala Leu Gln Met Glu Gln 
                325                 330                 335     


Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu Leu Ala Gln Thr Arg 
            340                 345                 350         


Ala Glu Gly Gln Arg Gln Ala Gln Glu Tyr Glu Ala Leu Leu Asn Ile 
        355                 360                 365             


Lys Val Lys Leu Glu Ala Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu 
    370                 375                 380                 


Asp Gly Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp Ser Ser Asn Ser 
385                 390                 395                 400 


Met Gln Thr Ile Gln Lys Thr Thr Thr Arg Arg Ile Val Asp Gly Lys 
                405                 410                 415     


Val Val Ser Glu Thr Asn Asp Thr Lys Val Leu Arg His 
            420                 425                 


<210>  19
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr 
1               5                   10                  15      


Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys 
            20                  25                  30          


Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val 
        35                  40                  45              


Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu 
    50                  55                  60                  


Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser 
65                  70                  75                  80  


Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys 
                85                  90                  95      


Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser 
            100                 105                 110         


Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu 
        115                 120                 125             


Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly 
    130                 135                 140                 


Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys 
145                 150                 155                 160 


Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu 
                165                 170                 175     


Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr 
            180                 185                 190         


Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile 
        195                 200                 205             


Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr 
    210                 215                 220                 


Ile Lys Arg Gly Arg 
225                 


<210>  20
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln 
1               5                   10                  15      


Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val 
            20                  25                  30          


Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met 
        35                  40                  45              


Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr 
    50                  55                  60                  


Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln 
65                  70                  75                  80  


Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr 
                85                  90                  95      


Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp 
            100                 105                 110         


His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu 
        115                 120                 125             


Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe 
    130                 135                 140                 


Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly 
145                 150                 155                 160 


Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala 
                165                 170                 175     


His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn 
            180                 185                 190         


Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser 
        195                 200                 205             


His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser 
    210                 215                 220                 


Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile 
225                 230                 235                 240 


Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro 
                245                 250                 255     


Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg 
            260                 265                 270         


Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro 
        275                 280                 285             


Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln 
    290                 295                 300                 


Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu 
305                 310                 315                 320 


Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn 
                325                 330                 335     


Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro 
            340                 345                 350         


Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly 
        355                 360                 365             


Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr 
    370                 375                 380                 


Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe 
385                 390                 395                 400 


Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe 
                405                 410                 415     


Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr 
            420                 425                 430         


Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg 
        435                 440                 445             


Lys Asn 
    450 


<210>  21
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp Glu 
1               5                   10                  15      


Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu Thr 
            20                  25                  30          


Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys Phe 
        35                  40                  45              


Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu Ile 
    50                  55                  60                  


Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser Leu 
65                  70                  75                  80  


Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg Ile 
                85                  90                  95      


Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu Val 
            100                 105                 110         


Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe Arg 
        115                 120                 125             


Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg Gly 
    130                 135                 140                 


Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu Ala 
145                 150                 155                 160 


His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe Asp 
                165                 170                 175     


Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe Leu 
            180                 185                 190         


Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His Ser 
        195                 200                 205             


Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp Pro 
    210                 215                 220                 


Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys Leu 
225                 230                 235                 240 


Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
                245                 250 


