                         SEQUENCE LISTING

<110>  King's College London
 
<120>  COMPOSITION

<130>  P6150GBWO

<150>  GB2109550.0
<151>  2021-07-01

<150>  PCT/EP2021/060749
<151>  2021-04-23

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOv18 IgE Light (L) Chain

<400>  1

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ile Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Ile Tyr Phe Cys Gln Gln Ser Ser Thr Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOv18 IgE Heavy (H) Chain

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Arg Ser Gly Lys Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ser Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Met Tyr Tyr Tyr Gly Ser Ser Pro Pro Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr 
    130                 135                 140                 


Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu 
                165                 170                 175     


Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu 
            180                 185                 190         


Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val 
        195                 200                 205             


Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser 
    210                 215                 220                 


Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
225                 230                 235                 240 


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
                245                 250                 255     


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
            260                 265                 270         


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
        275                 280                 285             


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
    290                 295                 300                 


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
305                 310                 315                 320 


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg 
                325                 330                 335     


Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile 
            340                 345                 350         


Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser 
        355                 360                 365             


Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val 
    370                 375                 380                 


Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr 
385                 390                 395                 400 


Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu 
                405                 410                 415     


Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met 
            420                 425                 430         


Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr 
        435                 440                 445             


Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu 
    450                 455                 460                 


Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp 
465                 470                 475                 480 


Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln 
                485                 490                 495     


Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu 
            500                 505                 510         


Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala 
        515                 520                 525             


Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser 
    530                 535                 540                 


Val Asn Pro Gly Lys 
545                 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOv18 IgE Light Chain Variable Domain

<400>  3

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ile Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Ile Tyr Phe Cys Gln Gln Ser Ser Thr Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOv18 IgE Heavy Chain Variable Domain

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Arg Ser Gly Lys Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ser Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Met Tyr Tyr Tyr Gly Ser Ser Pro Pro Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  6
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  6
atggctcagc ggatgacaac acagctgctg ctccttctag tgtgggtggc tgtagtaggg       60

gaggctcaga caaggattgc atgggccagg actgagcttc tcaatgtctg catgaacgcc      120

aagcaccaca aggaaaagcc aggccccgag gacaagttgc atgagcagtg tcgaccctgg      180

aggaagaatg cctgctgttc taccaacacc agccaggaag cccataagga tgtttcctac      240

ctatatagat tcaactggaa ccactgtgga gagatggcac ctgcctgcaa acggcatttc      300

atccaggaca cctgcctcta cgagtgctcc cccaacttgg ggccctggat ccagcaggtg      360

gatcagagct ggcgcaaaga gcgggtactg aacgtgcccc tgtgcaaaga ggactgtgag      420

caatggtggg aagattgtcg cacctcctac acctgcaaga gcaactggca caagggctgg      480

aactggactt cagggtttaa caagtgcgca gtgggagctg cctgccaacc tttccatttc      540

tacttcccca cacccactgt tctgtgcaat gaaatctgga ctcactccta caaggtcagc      600

aactacagcc gagggagtgg ccgctgcatc cagatgtggt tcgacccagc ccagggcaac      660

cccaatgagg aggtggcgag gttctatgct gcagccatga gtggggctgg gccctgggca      720

gcctggcctt tcctgcttag cctggcccta atgctgctgt ggctgctcag c               771


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Farletuzumab VH domain

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Met Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Asp Asp Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Farletuzumab VL domain

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VH domain

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOV19 VL domain

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VH-CDR1

<400>  11

Gly Tyr Phe Met Asn 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VH-CDR2

<400>  12

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VH-CDR3

<400>  13

Tyr Asp Gly Ser Arg Ala Met Asp Tyr 
1               5                   


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VL-CDR1

<400>  14

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Ser Leu Met His 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VL-CDR2

<400>  15

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMOv19 VL-CDR3

<400>  16

Gln Gln Ser Arg Glu Tyr Pro Tyr Thr 
1               5                   


