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<110>  JANSSEN PHARMACEUTICA NV
 
<120>  EXPRESSION SYSTEMS FOR THE ALPHA6BETA4 NICOTINIC ACETYLCHOLINE 
       RECEPTOR AND METHODS OF USE THEREOF

<130>  PRD4127WOPCT1

<150>  US 63/178835
<151>  2021-04-23

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Thr Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Thr Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Thr Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Thr Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Thr Gln Leu Ala Asn Val Asp Glu Val Asn Gln Ile Met 
65                  70                  75                  80  


Glu Thr Asn Leu Trp Leu Arg His Ile Trp Asn Asp Tyr Lys Leu Arg 
                85                  90                  95      


Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Thr Leu Arg Val Pro Ala 
            100                 105                 110         


Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val Gly 
        115                 120                 125             


Asp Phe Gln Val Glu Gly Lys Thr Lys Ala Leu Leu Lys Tyr Asn Gly 
    130                 135                 140                 


Met Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro Met 
145                 150                 155                 160 


Asp Ile Thr Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys Phe 
                165                 170                 175     


Gly Ser Trp Thr Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile Gly 
            180                 185                 190         


Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu Ile 
        195                 200                 205             


Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys Glu 
    210                 215                 220                 


Glu Ile Tyr Thr Asp Ile Thr Tyr Ser Phe Tyr Ile Arg Arg Leu Pro 
225                 230                 235                 240 


Met Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser Phe 
                245                 250                 255     


Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys Val 
            260                 265                 270         


Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val 
        275                 280                 285             


Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Val Pro Leu Val Gly 
    290                 295                 300                 


Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val Val 
305                 310                 315                 320 


Thr Val Phe Val Leu Asn Ile His Tyr Arg Thr Pro Thr Thr His Thr 
                325                 330                 335     


Met Pro Arg Trp Val Lys Thr Val Phe Leu Lys Leu Leu Pro Gln Val 
            340                 345                 350         


Leu Leu Met Arg Trp Pro Leu Asp Lys Thr Arg Gly Thr Gly Ser Asp 
        355                 360                 365             


Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu Ala 
    370                 375                 380                 


Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His Lys 
385                 390                 395                 400 


Ser Asn Glu Leu Ala Thr Ser Lys Arg Arg Leu Ser His Gln Pro Leu 
                405                 410                 415     


Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp Val 
            420                 425                 430         


Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn Glu 
        435                 440                 445             


Thr Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val Asp 
    450                 455                 460                 


Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Thr Ala 
465                 470                 475                 480 


Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Thr Gly Lys Ser 
                485                 490                 


<210>  2
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
1               5                   10                  15      


Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
            20                  25                  30          


Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Arg Pro Ala Thr 
        35                  40                  45              


Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
    50                  55                  60                  


Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Thr Thr Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Thr Asp Tyr Arg Leu Thr Trp Asn Ser Ser Arg 
                85                  90                  95      


Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Thr Tyr Glu Val Ser 
        115                 120                 125             


Val Tyr Thr Asn Leu Ile Val Arg Ser Asn Gly Ser Val Leu Trp Leu 
    130                 135                 140                 


Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys Tyr Phe 
145                 150                 155                 160 


Pro Phe Asp Gln Gln Asn Cys Thr Leu Lys Phe Arg Ser Trp Thr Tyr 
                165                 170                 175     


Asp His Thr Glu Ile Asp Met Val Leu Met Thr Pro Thr Ala Ser Met 
            180                 185                 190         


Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly 
        195                 200                 205             


Arg Arg Thr Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Thr Tyr 
    210                 215                 220                 


Asp Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Thr Ile Asn Leu Ile 
225                 230                 235                 240 


Ile Pro Cys Val Leu Thr Thr Leu Leu Ala Ile Leu Val Phe Tyr Leu 
                245                 250                 255     


Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val Leu Leu 
            260                 265                 270         


Ala Leu Thr Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Thr 
        275                 280                 285             


Ser Leu Asp Val Pro Leu Ile Gly Lys Tyr Leu Met Phe Thr Met Val 
    290                 295                 300                 


Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn Val His 
305                 310                 315                 320 


His Arg Ser Pro Ser Thr His Thr Met Ala Pro Trp Val Lys Arg Cys 
                325                 330                 335     


Phe Leu His Lys Leu Pro Thr Phe Leu Phe Met Lys Arg Pro Gly Pro 
            340                 345                 350         


Asp Ser Ser Pro Ala Arg Ala Phe Pro Pro Ser Lys Ser Cys Val Thr 
        355                 360                 365             


Lys Pro Glu Ala Thr Ala Thr Ser Thr Ser Pro Ser Asn Phe Tyr Gly 
    370                 375                 380                 


Asn Ser Met Tyr Phe Val Asn Pro Ala Ser Ala Ala Ser Lys Ser Pro 
385                 390                 395                 400 


Ala Gly Ser Thr Pro Val Ala Ile Pro Arg Asp Phe Trp Leu Arg Ser 
                405                 410                 415     


Ser Gly Arg Phe Arg Gln Asp Val Gln Glu Ala Leu Glu Gly Val Ser 
            420                 425                 430         


Phe Ile Ala Gln His Met Lys Asn Asp Asp Glu Asp Gln Ser Val Val 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Val Phe Met Phe Val Cys Val Leu Gly Thr Val Gly Leu Phe Leu Pro 
465                 470                 475                 480 


Pro Leu Phe Gln Thr His Ala Ala Ser Glu Gly Pro Tyr Ala Ala Gln 
                485                 490                 495     


Arg Asp 
        


<210>  3
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Pro Thr Ala Thr Met Ala Thr Ala Ala Thr Thr Thr Thr Thr 
1               5                   10                  15      


Thr Thr Ala Thr Val Ala Leu Thr Thr Ser Trp Asp Asn Ala Thr Gly 
            20                  25                  30          


Arg Pro Thr Ala Glu Pro Asp Pro Ile Leu Asp Asn Tyr Val Leu Leu 
        35                  40                  45              


Val Val Val Met Ser Leu Phe Val Gly Gly Thr Leu Val Val Leu Ser 
    50                  55                  60                  


Gly Val Leu Leu Leu Cys Lys Arg Cys Trp Asp Val His Gln Arg Leu 
65                  70                  75                  80  


Asn Arg Ala Met Glu Glu Ala Glu Lys Thr Thr Thr Thr Tyr Leu Asp 
                85                  90                  95      


Asn Gly Thr His Pro Ala Gln Asp Pro Asp Phe Arg Gly Glu Asp Pro 
            100                 105                 110         


Glu Cys Gln Asp Ala Glu Thr Glu Arg Phe Leu Ser Thr Ser Ser Thr 
        115                 120                 125             


Gly Arg Arg Val Ser Phe Asn Glu Ala Ala Leu Phe Glu Gln Ser Arg 
    130                 135                 140                 


Lys Thr Gln Asp Lys Gly Arg Arg Tyr Thr Leu Thr Glu Gly Asp Phe 
145                 150                 155                 160 


His His Leu Lys Asn Ala Arg Leu Thr His Leu His Leu Pro Pro Leu 
                165                 170                 175     


Lys Ile Val Thr Ile His Glu Cys Asp Ser Gly Glu Ala Ser Ser Ala 
            180                 185                 190         


Thr Thr Pro His Pro Ala Thr Ser Pro Lys Ala Thr Leu Ala Ile Phe 
        195                 200                 205             


Gln Pro Pro Gly Lys Ala Leu Thr Gly Arg Ser Val Gly Pro Ser Ser 
    210                 215                 220                 


Ala Leu Pro Gly Asp Pro Tyr Asn Ser Ala Ala Gly Ala Thr Asp Phe 
225                 230                 235                 240 


Ala Glu Ile Ser Pro Ser Ala Ser Ser Asp Ser Gly Glu Gly Thr Ser 
                245                 250                 255     


Leu Asp Ala Gly Thr Arg Ser Thr Lys Ala Gly Gly Pro Gly Ala Ala 
            260                 265                 270         


Ala Gly Pro Gly Glu Ala Gly Pro Gly Ser Gly Ala Gly Thr Val Leu 
        275                 280                 285             


Gln Phe Leu Thr Arg Leu Arg Arg His Ala Ser Leu Asp Gly Ala Ser 
    290                 295                 300                 


Pro Tyr Phe Lys Val Lys Lys Trp Lys Leu Glu Pro Ser Gln Arg Ala 
305                 310                 315                 320 


Ala Ser Leu Asp Thr Arg Gly Ser Pro Lys Arg His His Phe Gln Arg 
                325                 330                 335     


Gln Arg Ala Ala Ser Glu Ser Thr Glu Gln Glu Glu Gly Asp Ala Pro 
            340                 345                 350         


Gln Glu Asp Phe Ile Gln Tyr Ile Ala Arg Ala Gly Asp Ala Val Ala 
        355                 360                 365             


Phe Pro His Pro Arg Pro Phe Leu Ala Ser Pro Pro Pro Ala Leu Gly 
    370                 375                 380                 


Arg Leu Glu Ala Ala Glu Ala Ala Gly Gly Ala Ser Pro Asp Ser Pro 
385                 390                 395                 400 


Pro Glu Arg Gly Ala Gly Ser Ala Gly Pro Glu Gln Gln Gln Pro Pro 
                405                 410                 415     


Leu Glu Pro Asp Ala Glu Arg Asp Ala Gly Pro Glu Gln Ala Gln Thr 
            420                 425                 430         


Ser Tyr Arg Asp Leu Trp Ser Leu Arg Ala Ser Leu Glu Leu His Ala 
        435                 440                 445             


Ala Ala Ser Asp His Ser Ser Ser Gly Asn Asp Arg Asp Ser Val Arg 
    450                 455                 460                 


Ser Gly Asp Ser Ser Gly Ser Gly Ser Gly Gly Ala Ala Pro Ala Phe 
465                 470                 475                 480 


Pro Pro Pro Ser Pro Pro Ala Pro Arg Pro Lys Asp Gly Glu Ala Arg 
                485                 490                 495     


Arg Leu Leu Gln Met Asp Ser Gly Tyr Ala Ser Ile Glu Gly Arg Gly 
            500                 505                 510         


Ala Gly Asp Asp Thr Glu Pro Pro Ala Ala Pro Ala Arg Pro Arg Ser 
        515                 520                 525             


Pro Arg Ala Trp Pro Arg Arg Pro Arg Arg Asp Tyr Ser Ile Asp Glu 
    530                 535                 540                 


Lys Thr Asp Ala Leu Phe His Glu Phe Leu Arg His Asp Pro His Phe 
545                 550                 555                 560 


Asp Asp Thr Pro Ala Ala Ala Arg His Arg Ala Arg Ala His Pro His 
                565                 570                 575     


Ala Arg Lys Gln Trp Gln Arg Gly Arg Gln His Ser Asp Pro Gly Ala 
            580                 585                 590         


Arg Ala Ala Pro Ala Leu Ala Gly Thr Pro Ala Pro Pro Ala Gly Ala 
        595                 600                 605             


Ala Arg Pro Ala Arg Ala Pro Leu Arg Arg Gly Asp Ser Val Asp Gly 
    610                 615                 620                 


Pro Pro Asp Gly Arg Thr Leu Gly Gly Ala Gly Asp Asp Pro Ala Ile 
625                 630                 635                 640 


Pro Val Ile Glu Glu Glu Pro Gly Gly Gly Gly Cys Pro Gly Ser Gly 
                645                 650                 655     


Leu Cys Val Leu Pro Ser Gly Ser Val Leu Asp Lys Leu Ala Ala Gly 
            660                 665                 670         


Leu Asp Glu Arg Leu Phe Pro Pro Arg Leu Ala Glu Pro Val Val Ala 
        675                 680                 685             


Thr Pro Ala Leu Val Ala Ala Ala Pro Thr Ser Pro Asp His Ser Pro 
    690                 695                 700                 


Ala 
705 


<210>  4
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Lys Thr Pro Ser Ser Glu Glu Ser Gly Leu Pro Lys Leu 
1               5                   10                  15      


Pro Val Pro Pro Leu Gln Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met 
            20                  25                  30          


Arg His Leu Val Ser Glu Glu Gln Phe Arg Lys Ser Gln Ala Ile Val 
        35                  40                  45              


Gln Gln Phe Gly Ala Pro Gly Gly Leu Gly Glu Thr Leu Gln Gln Lys 
    50                  55                  60                  


Leu Leu Glu Arg Gln Glu Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp 
65                  70                  75                  80  


Leu Asn Asp Met Tyr Leu Asn Asn Arg Leu Ala Leu Pro Val Asn Ser 
                85                  90                  95      


Ser Pro Ala Val Ile Phe Ala Arg Gln His Phe Pro Gly Thr Asp Asp 
            100                 105                 110         


Gln Leu Arg Phe Ala Ala Ser Leu Ile Ser Gly Val Leu Ser Tyr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ser His Ser Ile Pro Thr Asp Cys Ala Lys Gly Gln 
    130                 135                 140                 


Leu Ser Gly Gln Pro Leu Cys Met Lys Gln Tyr Tyr Gly Leu Phe Ser 
145                 150                 155                 160 


Ser Tyr Arg Leu Pro Gly His Thr Gln Asp Thr Leu Val Ala Gln Asn 
                165                 170                 175     


Ser Ser Ile Met Pro Glu Pro Glu His Val Ile Val Ala Cys Cys Asn 
            180                 185                 190         


Gln Phe Phe Val Leu Asp Val Val Ile Asn Phe Arg Arg Leu Ser Glu 
        195                 200                 205             


Gly Asp Leu Phe Thr Gln Leu Arg Lys Ile Val Lys Met Ala Ser Asn 
    210                 215                 220                 


Glu Asp Glu Arg Leu Pro Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg 
225                 230                 235                 240 


Ser Glu Trp Ala Glu Ala Arg Thr Val Leu Val Lys Asp Ser Thr Asn 
                245                 250                 255     


Arg Asp Ser Leu Asp Met Ile Glu Arg Cys Ile Cys Leu Val Cys Leu 
            260                 265                 270         


Asp Ala Pro Gly Gly Val Glu Leu Ser Asp Thr His Arg Ala Leu Gln 
        275                 280                 285             


Leu Leu His Gly Gly Gly Tyr Ser Lys Asn Gly Ala Asn Arg Trp Tyr 
    290                 295                 300                 


Asp Lys Ser Leu Gln Phe Val Val Gly Arg Asp Gly Thr Cys Gly Val 
305                 310                 315                 320 


Val Cys Glu His Ser Pro Phe Asp Gly Ile Val Leu Val Gln Cys Thr 
                325                 330                 335     


Glu His Leu Leu Lys His Met Thr Gln Ser Ser Arg Lys Leu Ile Arg 
            340                 345                 350         


Ala Asp Ser Val Ser Glu Leu Pro Ala Pro Arg Arg Leu Arg Trp Lys 
        355                 360                 365             


Cys Ser Pro Glu Ile Gln Gly His Leu Ala Ser Ser Ala Glu Lys Leu 
    370                 375                 380                 


Gln Arg Ile Val Lys Asn Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn 
385                 390                 395                 400 


Tyr Gly Lys Thr Phe Ile Lys Lys Gln Lys Cys Ser Pro Asp Ala Phe 
                405                 410                 415     


Ile Gln Val Ala Leu Gln Leu Ala Phe Tyr Arg Leu His Arg Arg Leu 
            420                 425                 430         


Val Pro Thr Tyr Glu Ser Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg 
        435                 440                 445             


Val Asp Asn Ile Arg Ser Ala Thr Pro Glu Ala Leu Ala Phe Val Arg 
    450                 455                 460                 


Ala Val Thr Asp His Lys Ala Ala Val Pro Ala Ser Glu Lys Leu Leu 
465                 470                 475                 480 


Leu Leu Lys Asp Ala Ile Arg Ala Gln Thr Ala Tyr Thr Val Met Ala 
                485                 490                 495     


Ile Thr Gly Met Ala Ile Asp Asn His Leu Leu Ala Leu Arg Glu Leu 
            500                 505                 510         


Ala Arg Ala Met Cys Lys Glu Leu Pro Glu Met Phe Met Asp Glu Thr 
        515                 520                 525             


Tyr Leu Met Ser Asn Arg Phe Val Leu Ser Thr Ser Gln Val Pro Thr 
    530                 535                 540                 


Thr Thr Glu Met Phe Cys Cys Tyr Gly Pro Val Val Pro Asn Gly Tyr 
545                 550                 555                 560 


Gly Ala Cys Tyr Asn Pro Gln Pro Glu Thr Ile Leu Phe Cys Ile Ser 
                565                 570                 575     


Ser Phe His Ser Cys Lys Glu Thr Ser Ser Ser Lys Phe Ala Lys Ala 
            580                 585                 590         


Val Glu Glu Ser Leu Ile Asp Met Arg Asp Leu Cys Ser Leu Leu Pro 
        595                 600                 605             


Pro Thr Glu Ser Lys Pro Leu Ala Thr Lys Glu Lys Ala Thr Arg Pro 
    610                 615                 620                 


Ser Gln Gly His Gln Pro 
625                 630 


<210>  5
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Gly Pro Ala Glu Pro Gln Ile Pro Gly Leu Trp Asp Thr Tyr 
1               5                   10                  15      


Glu Asp Asp Ile Ser Glu Ile Ser Gln Lys Leu Pro Gly Glu Tyr Phe 
            20                  25                  30          


Arg Tyr Lys Gly Val Pro Phe Pro Val Gly Leu Tyr Ser Leu Glu Ser 
        35                  40                  45              


Ile Ser Leu Ala Glu Asn Thr Gln Asp Val Arg Asp Asp Asp Ile Phe 
    50                  55                  60                  


Ile Ile Thr Tyr Pro Lys Ser Gly Thr Thr Trp Met Ile Glu Ile Ile 
65                  70                  75                  80  


Cys Leu Ile Leu Lys Glu Gly Asp Pro Ser Trp Ile Arg Ser Val Pro 
                85                  90                  95      


Ile Trp Glu Arg Ala Pro Trp Cys Glu Thr Ile Val Gly Ala Phe Ser 
            100                 105                 110         


Leu Pro Asp Gln Tyr Ser Pro Arg Leu Met Ser Ser His Leu Pro Ile 
        115                 120                 125             


Gln Ile Phe Thr Lys Ala Phe Phe Ser Ser Lys Ala Lys Val Ile Tyr 
    130                 135                 140                 


Met Gly Arg Asn Pro Arg Asp Val Val Val Ser Leu Tyr His Tyr Ser 
145                 150                 155                 160 


Lys Ile Ala Gly Gln Leu Lys Asp Pro Gly Thr Pro Asp Gln Phe Leu 
                165                 170                 175     


Arg Asp Phe Leu Lys Gly Glu Val Gln Phe Gly Ser Trp Phe Asp His 
            180                 185                 190         


Ile Lys Gly Trp Leu Arg Met Lys Gly Lys Asp Asn Phe Leu Phe Ile 
        195                 200                 205             


Thr Tyr Glu Glu Leu Gln Gln Asp Leu Gln Gly Ser Val Glu Arg Ile 
    210                 215                 220                 


Cys Gly Phe Leu Gly Arg Pro Leu Gly Lys Glu Ala Leu Gly Ser Val 
225                 230                 235                 240 


Val Ala His Ser Thr Phe Ser Ala Met Lys Ala Asn Thr Met Ser Asn 
                245                 250                 255     


Tyr Thr Leu Leu Pro Pro Ser Leu Leu Asp His Arg Arg Gly Ala Phe 
            260                 265                 270         


Leu Arg Lys Gly Val Cys Gly Asp Trp Lys Asn His Phe Thr Val Ala 
        275                 280                 285             


Gln Ser Glu Ala Phe Asp Arg Ala Tyr Arg Lys Gln Met Arg Gly Met 
    290                 295                 300                 


Pro Thr Phe Pro Trp Asp Glu Asp Pro Glu Glu Asp Gly Ser Pro Asp 
305                 310                 315                 320 


Pro Glu Pro Ser Pro Glu Pro Glu Pro Lys Pro Ser Leu Glu Pro Asn 
                325                 330                 335     


Thr Ser Leu Glu Arg Glu Pro Arg Pro Asn Ser Ser Pro Ser Pro Ser 
            340                 345                 350         


Pro Gly Gln Ala Ser Glu Thr Pro His Pro Arg Pro Ser 
        355                 360                 365 


