                         SEQUENCE LISTING

<110>  MIAMI UNIVERSITY
       Jones, John Andrew
       O'Dell, Philip John
 
<120>  OPTIMIZED METHODS FOR THE PRODUCTION OF PSILOCYBIN AND 
       INTERMEDIATES OR SIDE PRODUCTS

<130>  315691-00020

<150>  63/176,590
<151>  2021-04-19

<150>  63/263,611
<151>  2021-11-05

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  1320
<212>  DNA
<213>  Psilocybe cubensis

<400>  1
atgcaggtga tacccgcgtg caactcggca gcaataagat cactatgtcc tactcccgag       60

tcttttagaa acatgggatg gctctctgtc agcgatgcgg tctacagcga gttcatagga      120

gagttggcta cccgcgcttc caatcgaaat tactccaacg agttcggcct catgcaacct      180

atccaggaat tcaaggcttt cattgaaagc gacccggtgg tgcaccaaga atttattgac      240

atgttcgagg gcattcagga ctctccaagg aattatcagg aactatgtaa tatgttcaac      300

gatatctttc gcaaagctcc cgtctacgga gaccttggcc ctcccgttta tatgattatg      360

gccaaattaa tgaacacccg agcgggcttc tctgcattca cgagacaaag gttgaacctt      420

cacttcaaaa aacttttcga tacctgggga ttgttcctgt cttcgaaaga ttctcgaaat      480

gttcttgtgg ccgaccagtt cgacgacaga cattgcggct ggttgaacga gcgggccttg      540

tctgctatgg ttaaacatta caatggacgc gcatttgatg aagtcttcct ctgcgataaa      600

aatgccccat actacggctt caactcttac gacgacttct ttaatcgcag atttcgaaac      660

cgagatatcg accgacctgt agtcggtgga gttaacaaca ccaccctcat ttctgctgct      720

tgcgaatcac tttcctacaa cgtctcttat gacgtccagt ctctcgacac tttagttttc      780

aaaggagaga cttattcgct taagcatttg ctgaataatg accctttcac cccacaattc      840

gagcatggga gtattctaca aggattcttg aacgtcaccg cttaccaccg atggcacgca      900

cccgtcaatg ggacaatcgt caaaatcatc aacgttccag gtacctactt tgcgcaagcc      960

ccgagcacga ttggcgaccc tatcccggat aacgattacg acccacctcc ttaccttaag     1020

tctcttgtct acttctctaa tattgccgca aggcaaatta tgtttattga agccgacaac     1080

aaggaaattg gcctcatttt ccttgtgttc atcggcatga ccgaaatctc gacatgtgaa     1140

gccacggtgt ccgaaggtca acacgtcaat cgtggcgatg acttgggaat gttccatttc     1200

ggtggttctt cgttcgcgct tggtctgagg aaggattgca gggcagagat cgttgaaaag     1260

ttcaccgaac ccggaacagt gatcagaatc aacgaagtcg tcgctgctct aaaggcttag     1320


<210>  2
<211>  1089
<212>  DNA
<213>  Psilocybe cubensis

<400>  2
atggcgttcg atctcaagac tgaagacggc ctcatcacat atctcactaa acatctttct       60

ttggacgtcg acacgagcgg agtgaagcgc cttagcggag gctttgtcaa tgtaacctgg      120

cgcattaagc tcaatgctcc ttatcaaggt catacgagca tcatcctgaa gcatgctcag      180

ccgcacatgt ctacggatga ggattttaag ataggtgtag aacgttcggt ttacgaatac      240

caggctatca agctcatgat ggccaatcgg gaggttctgg gaggcgtgga tggcatagtt      300

tctgtgccag aaggcctgaa ctacgactta gagaataatg cattgatcat gcaagatgtc      360

gggaagatga agaccctttt agattatgtc accgccaaac cgccacttgc gacggatata      420

gcccgccttg ttgggacaga aattgggggg ttcgttgcca gactccataa cataggccgc      480

gagaggcgag acgatcctga gttcaaattc ttctctggaa atattgtcgg aaggacgact      540

tcagaccagc tgtatcaaac catcataccc aacgcagcga aatatggcgt cgatgacccc      600

ttgctgccta ctgtggttaa ggaccttgtg gacgatgtca tgcacagcga agagaccctt      660

gtcatggcgg acctgtggag tggaaatatt cttctccagt tggaggaggg aaacccatcg      720

aagctgcaga agatatatat cctggattgg gaactttgca agtacggccc agcgtcgttg      780

gacctgggct atttcttggg tgactgctat ttgatatccc gctttcaaga cgagcaggtc      840

ggtacgacga tgcggcaagc ctacttgcaa agctatgcgc gtacgagcaa gcattcgatc      900

aactacgcca aagtcactgc aggtattgct gctcatattg tgatgtggac cgactttatg      960

cagtggggga gcgaggaaga aaggataaat tttgtgaaaa agggggtagc tgcctttcac     1020

gacgccaggg gcaacaacga caatggggaa attacgtcta ccttactgaa ggaatcatcc     1080

actgcgtaa                                                             1089


<210>  3
<211>  930
<212>  DNA
<213>  Psilocybe cubensis

<400>  3
atgcatatca gaaatcctta ccgtacacca attgactatc aagcactttc agaggccttc       60

cctcccctca agccatttgt gtctgtcaat gcagatggta ccagttctgt tgacctcact      120

atcccagaag cccagagggc gttcacggcc gctcttcttc atcgtgactt cgggctcacc      180

atgaccatac cagaagaccg tctgtgccca acagtcccca ataggttgaa ctacgttctg      240

tggattgaag atattttcaa ctacacgaac aaaaccctcg gcctgtcgga tgaccgtcct      300

attaaaggcg ttgatattgg tacaggagcc tccgcaattt atcctatgct tgcctgtgct      360

cggttcaagg catggtctat ggttggaaca gaggtcgaga ggaagtgcat tgacacggcc      420

cgcctcaatg tcgtcgcgaa caatctccaa gaccgtctct cgatattaga gacatccatt      480

gatggtccta ttctcgtccc cattttcgag gcgactgaag aatacgaata cgagtttact      540

atgtgtaacc ctccattcta cgacggtgct gccgatatgc agacttcgga tgctgccaaa      600

ggatttggat ttggcgtggg cgctccccat tctggaacag tcatcgaaat gtcgactgag      660

ggaggtgaat cggctttcgt cgctcagatg gtccgtgaga gcttgaagct tcgaacacga      720

tgcagatggt acacgagtaa cttgggaaag ctgaaatcct tgaaagaaat agtggggctg      780

ctgaaagaac ttgagataag caactatgcc attaacgaat acgttcaggg gtccacacgt      840

cgttatgccg ttgcgtggtc tttcactgat attcaactgc ctgaggagct ttctcgtccc      900

tctaaccccg agctcagctc tcttttctag                                       930


<210>  4
<211>  439
<212>  PRT
<213>  Psilocybe cubensis

<400>  4

Met Gln Val Ile Pro Ala Cys Asn Ser Ala Ala Ile Arg Ser Leu Cys 
1               5                   10                  15      


Pro Thr Pro Glu Ser Phe Arg Asn Met Gly Trp Leu Ser Val Ser Asp 
            20                  25                  30          


Ala Val Tyr Ser Glu Phe Ile Gly Glu Leu Ala Thr Arg Ala Ser Asn 
        35                  40                  45              


Arg Asn Tyr Ser Asn Glu Phe Gly Leu Met Gln Pro Ile Gln Glu Phe 
    50                  55                  60                  


Lys Ala Phe Ile Glu Ser Asp Pro Val Val His Gln Glu Phe Ile Asp 
65                  70                  75                  80  


Met Phe Glu Gly Ile Gln Asp Ser Pro Arg Asn Tyr Gln Glu Leu Cys 
                85                  90                  95      


Asn Met Phe Asn Asp Ile Phe Arg Lys Ala Pro Val Tyr Gly Asp Leu 
            100                 105                 110         


Gly Pro Pro Val Tyr Met Ile Met Ala Lys Leu Met Asn Thr Arg Ala 
        115                 120                 125             


Gly Phe Ser Ala Phe Thr Arg Gln Arg Leu Asn Leu His Phe Lys Lys 
    130                 135                 140                 


Leu Phe Asp Thr Trp Gly Leu Phe Leu Ser Ser Lys Asp Ser Arg Asn 
145                 150                 155                 160 


Val Leu Val Ala Asp Gln Phe Asp Asp Arg His Cys Gly Trp Leu Asn 
                165                 170                 175     


Glu Arg Ala Leu Ser Ala Met Val Lys His Tyr Asn Gly Arg Ala Phe 
            180                 185                 190         


Asp Glu Val Phe Leu Cys Asp Lys Asn Ala Pro Tyr Tyr Gly Phe Asn 
        195                 200                 205             


Ser Tyr Asp Asp Phe Phe Asn Arg Arg Phe Arg Asn Arg Asp Ile Asp 
    210                 215                 220                 


Arg Pro Val Val Gly Gly Val Asn Asn Thr Thr Leu Ile Ser Ala Ala 
225                 230                 235                 240 


Cys Glu Ser Leu Ser Tyr Asn Val Ser Tyr Asp Val Gln Ser Leu Asp 
                245                 250                 255     


Thr Leu Val Phe Lys Gly Glu Thr Tyr Ser Leu Lys His Leu Leu Asn 
            260                 265                 270         


Asn Asp Pro Phe Thr Pro Gln Phe Glu His Gly Ser Ile Leu Gln Gly 
        275                 280                 285             


Phe Leu Asn Val Thr Ala Tyr His Arg Trp His Ala Pro Val Asn Gly 
    290                 295                 300                 


Thr Ile Val Lys Ile Ile Asn Val Pro Gly Thr Tyr Phe Ala Gln Ala 
305                 310                 315                 320 


Pro Ser Thr Ile Gly Asp Pro Ile Pro Asp Asn Asp Tyr Asp Pro Pro 
                325                 330                 335     


Pro Tyr Leu Lys Ser Leu Val Tyr Phe Ser Asn Ile Ala Ala Arg Gln 
            340                 345                 350         


Ile Met Phe Ile Glu Ala Asp Asn Lys Glu Ile Gly Leu Ile Phe Leu 
        355                 360                 365             


Val Phe Ile Gly Met Thr Glu Ile Ser Thr Cys Glu Ala Thr Val Ser 
    370                 375                 380                 


Glu Gly Gln His Val Asn Arg Gly Asp Asp Leu Gly Met Phe His Phe 
385                 390                 395                 400 


Gly Gly Ser Ser Phe Ala Leu Gly Leu Arg Lys Asp Cys Arg Ala Glu 
                405                 410                 415     


Ile Val Glu Lys Phe Thr Glu Pro Gly Thr Val Ile Arg Ile Asn Glu 
            420                 425                 430         


Val Val Ala Ala Leu Lys Ala 
        435                 


<210>  5
<211>  362
<212>  PRT
<213>  Psilocybe cubensis

<400>  5

Met Ala Phe Asp Leu Lys Thr Glu Asp Gly Leu Ile Thr Tyr Leu Thr 
1               5                   10                  15      


Lys His Leu Ser Leu Asp Val Asp Thr Ser Gly Val Lys Arg Leu Ser 
            20                  25                  30          


Gly Gly Phe Val Asn Val Thr Trp Arg Ile Lys Leu Asn Ala Pro Tyr 
        35                  40                  45              


Gln Gly His Thr Ser Ile Ile Leu Lys His Ala Gln Pro His Met Ser 
    50                  55                  60                  


Thr Asp Glu Asp Phe Lys Ile Gly Val Glu Arg Ser Val Tyr Glu Tyr 
65                  70                  75                  80  


Gln Ala Ile Lys Leu Met Met Ala Asn Arg Glu Val Leu Gly Gly Val 
                85                  90                  95      


Asp Gly Ile Val Ser Val Pro Glu Gly Leu Asn Tyr Asp Leu Glu Asn 
            100                 105                 110         


Asn Ala Leu Ile Met Gln Asp Val Gly Lys Met Lys Thr Leu Leu Asp 
        115                 120                 125             


Tyr Val Thr Ala Lys Pro Pro Leu Ala Thr Asp Ile Ala Arg Leu Val 
    130                 135                 140                 


Gly Thr Glu Ile Gly Gly Phe Val Ala Arg Leu His Asn Ile Gly Arg 
145                 150                 155                 160 


Glu Arg Arg Asp Asp Pro Glu Phe Lys Phe Phe Ser Gly Asn Ile Val 
                165                 170                 175     


Gly Arg Thr Thr Ser Asp Gln Leu Tyr Gln Thr Ile Ile Pro Asn Ala 
            180                 185                 190         


Ala Lys Tyr Gly Val Asp Asp Pro Leu Leu Pro Thr Val Val Lys Asp 
        195                 200                 205             


Leu Val Asp Asp Val Met His Ser Glu Glu Thr Leu Val Met Ala Asp 
    210                 215                 220                 


Leu Trp Ser Gly Asn Ile Leu Leu Gln Leu Glu Glu Gly Asn Pro Ser 
225                 230                 235                 240 


Lys Leu Gln Lys Ile Tyr Ile Leu Asp Trp Glu Leu Cys Lys Tyr Gly 
                245                 250                 255     


Pro Ala Ser Leu Asp Leu Gly Tyr Phe Leu Gly Asp Cys Tyr Leu Ile 
            260                 265                 270         


Ser Arg Phe Gln Asp Glu Gln Val Gly Thr Thr Met Arg Gln Ala Tyr 
        275                 280                 285             


Leu Gln Ser Tyr Ala Arg Thr Ser Lys His Ser Ile Asn Tyr Ala Lys 
    290                 295                 300                 


Val Thr Ala Gly Ile Ala Ala His Ile Val Met Trp Thr Asp Phe Met 
305                 310                 315                 320 


Gln Trp Gly Ser Glu Glu Glu Arg Ile Asn Phe Val Lys Lys Gly Val 
                325                 330                 335     


Ala Ala Phe His Asp Ala Arg Gly Asn Asn Asp Asn Gly Glu Ile Thr 
            340                 345                 350         


Ser Thr Leu Leu Lys Glu Ser Ser Thr Ala 
        355                 360         


<210>  6
<211>  309
<212>  PRT
<213>  Psilocybe cubensis

<400>  6

Met His Ile Arg Asn Pro Tyr Arg Thr Pro Ile Asp Tyr Gln Ala Leu 
1               5                   10                  15      


Ser Glu Ala Phe Pro Pro Leu Lys Pro Phe Val Ser Val Asn Ala Asp 
            20                  25                  30          


Gly Thr Ser Ser Val Asp Leu Thr Ile Pro Glu Ala Gln Arg Ala Phe 
        35                  40                  45              


Thr Ala Ala Leu Leu His Arg Asp Phe Gly Leu Thr Met Thr Ile Pro 
    50                  55                  60                  


Glu Asp Arg Leu Cys Pro Thr Val Pro Asn Arg Leu Asn Tyr Val Leu 
65                  70                  75                  80  


Trp Ile Glu Asp Ile Phe Asn Tyr Thr Asn Lys Thr Leu Gly Leu Ser 
                85                  90                  95      


Asp Asp Arg Pro Ile Lys Gly Val Asp Ile Gly Thr Gly Ala Ser Ala 
            100                 105                 110         


Ile Tyr Pro Met Leu Ala Cys Ala Arg Phe Lys Ala Trp Ser Met Val 
        115                 120                 125             


Gly Thr Glu Val Glu Arg Lys Cys Ile Asp Thr Ala Arg Leu Asn Val 
    130                 135                 140                 


Val Ala Asn Asn Leu Gln Asp Arg Leu Ser Ile Leu Glu Thr Ser Ile 
145                 150                 155                 160 


Asp Gly Pro Ile Leu Val Pro Ile Phe Glu Ala Thr Glu Glu Tyr Glu 
                165                 170                 175     


Tyr Glu Phe Thr Met Cys Asn Pro Pro Phe Tyr Asp Gly Ala Ala Asp 
            180                 185                 190         


Met Gln Thr Ser Asp Ala Ala Lys Gly Phe Gly Phe Gly Val Gly Ala 
        195                 200                 205             


Pro His Ser Gly Thr Val Ile Glu Met Ser Thr Glu Gly Gly Glu Ser 
    210                 215                 220                 


Ala Phe Val Ala Gln Met Val Arg Glu Ser Leu Lys Leu Arg Thr Arg 
225                 230                 235                 240 


Cys Arg Trp Tyr Thr Ser Asn Leu Gly Lys Leu Lys Ser Leu Lys Glu 
                245                 250                 255     


Ile Val Gly Leu Leu Lys Glu Leu Glu Ile Ser Asn Tyr Ala Ile Asn 
            260                 265                 270         


Glu Tyr Val Gln Gly Ser Thr Arg Arg Tyr Ala Val Ala Trp Ser Phe 
        275                 280                 285             


Thr Asp Ile Gln Leu Pro Glu Glu Leu Ser Arg Pro Ser Asn Pro Glu 
    290                 295                 300                 


Leu Ser Ser Leu Phe 
305                 


<210>  7
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  H10 mutant T7 promoter

<400>  7
taatacgact cactacggaa gaa                                               23


<210>  8
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  G6 mutant T7 promoter

<400>  8
taatacgact cactatttcg gaa                                               23


<210>  9
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  H9 mutant T7 promoter

<400>  9
taatacgact cactaatact gaa                                               23


<210>  10
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  C4 mutant T7 promoter

<400>  10
taatacgact cactatcaag gaa                                               23


<210>  11
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  consensus T7 promoter

<400>  11
taatacgact cactataggg gaa                                               23


<210>  12
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Kan_FRT_fwd_nheI (nheI cut site)

<400>  12
gcgcgggcta gcacacgtct tgagcgattg tg                                     32


<210>  13
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Kan_FRT_rev_SalI (SalI cut site)

<400>  13
gcgcgggtcg acaacggctg acatgggaat tag                                    33


<210>  14
<211>  41
<212>  DNA
<213>  artificial sequence

<220>
<223>  transposon_DNA_fwd (ME seq, 5' P)

<400>  14
ctgtctctta tacacatctt cggtgatgtc ggcgatatag g                           41


<210>  15
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  transposon_DNA_rev (ME seq, 5'P)

<400>  15
ctgtctctta tacacatctc atgggaatta gccatggtcc atatg                       45


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Seq_REV_pETM6

<400>  16
gtaaccacca cacccgccgc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  chk_REV-KanR2

<400>  17
tatgtcctga tagcggtccg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  chk_REV_KanR

<400>  18
tgacaacgtc gagcacagct                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  genome_seq_rev

<400>  19
ctatatcgcc gacatcaccg                                                   20


<210>  20
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  CvAII_linker_fwd


<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  n is a, c, g, or t

<400>  20
actacgcacg cgacgannnn gacgtagcgt g                                      31


<210>  21
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  CvAII_linker_rev (inosine,5' P)


<220>
<221>  inosine
<222>  (14)..(17)
<223>  n is inosine (I)

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  n is a, c, g, or t

<400>  21
atcacgctac gtcnnnncgt gttgtcggtc ctg                                    33


<210>  22
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  Genome_seq_fwd

<400>  22
actacgcacg cgacga                                                       16


<210>  23
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  pKD-T7 fwd (sgRNA for T7)

<400>  23
attaatacga ctcactatag gttttagagc tagaaatagc aag                         43


<210>  24
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  pKD-T7 rev (sgRNA for T7)

<400>  24
ctatagtgag tcgtattaat gtgctcagta tctctatcac tga                         43


<210>  25
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  C4 fwd

<400>  25
gcgtagtcta gaatcgagat cgatctcgat cccgcgaaat taatacgact cactatcaag       60

gaattgtgag                                                              70


<210>  26
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  C4 rev

<400>  26
cggataacaa ttccccccta ggaataattt tgtttaactt taagaaggag ctcacaattc       60

cttgatagtg                                                              70


<210>  27
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  H10 fwd

<400>  27
gcgtagtcta gaatcgagat cgatctcgat cccgcgaaat taatacgact cactacggaa       60

gaattgtgag                                                              70


<210>  28
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  H10 rev

<400>  28
cggataacaa ttccccccta ggaataattt tgtttaactt taagaaggag ctcacaattc       60

ttccgtagtg                                                              70


<210>  29
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  H9 fwd

<400>  29
gcgtagtcta gaatcgagat cgatctcgat cccgcgaaat taatacgact cactaatact       60

gaattgtgag                                                              70


<210>  30
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  H9 rev

<400>  30
cggataacaa ttccccccta ggaataattt tgtttaactt taagaaggag ctcacaattc       60

agtattagtg                                                              70


<210>  31
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  G6 fwd

<400>  31
gcgtagtcta gaatcgagat cgatctcgat cccgcgaaat taatacgact cactatttcg       60

gaattgtgag                                                              70


<210>  32
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  G6 rev

<400>  32
cggataacaa ttccccccta ggaataattt tgtttaactt taagaaggag ctcacaattc       60

cgaaatagtg                                                              70


<210>  33
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  BetaR (sgRNA for T7)

<400>  33
tttataacct ccttagagct cga                                               23


<210>  34
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  pKD_Seq1 (sgRNA for T7)

<400>  34
ccaattgtcc atattgcatc a                                                 21


<210>  35
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  T7 Term REV

<400>  35
gctagttatt gctcagcggt gg                                                22


<210>  36
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  T7 cPCR fwd

<400>  36
taatacgact cactataggg                                                   20


<210>  37
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  C4 cPCR fwd

<400>  37
taatacgact cactatcaag g                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  H9 cPCR fwd

<400>  38
taatacgact cactacggaa g                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  H10 cPCR fwd

<400>  39
taatacgact cactaatact g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  G6 cPCR fwd

<400>  40
taatacgact cactatttcg g                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IPCR Gen_Seq_FWD

<400>  41
tatgaaaggt tgggcttcgg                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  ME

<400>  42
ctgtctctta tacacatct                                                    19


