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<110>  ԭƼϺι˾ 

<120>  BCMAǶϿԭ弰Ӧ

<130>  0065-PA-047

<160>  107

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ser 
            20                  25                  30          


Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  3
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  3

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  4
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Ser Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Ser Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  10

Arg Ala Ser Glu Ser Val Ser Val Ile Gly Ala His Leu Ile His 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  11

Arg Ala Ser Glu Ser Val Ser Val Ser Gly Ile His Leu Leu His 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  12

Arg Ala Ser Glu Ser Val Ser Val Pro Gly Ile Ser Phe Ile His 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  13

Leu Gly Arg Asn Arg Ala Ala 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  14

Leu Gly Ser Asn Arg Pro Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  15

Leu Gln Ser Arg Ile Phe Pro Arg Thr 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  16

Leu Gln Ser Arg Arg Phe Pro Arg His 
1               5                   


<210>  17
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  18
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2

<400>  18

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  19
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3

<400>  19

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  20
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4

<400>  20

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  21
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  21

Asp Tyr Thr Ile Asn 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  22

Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  23

Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Ser 
    


<210>  24
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  24

Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Ser 
    


<210>  25
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  25

Asp Ile Arg Tyr Val Met Asp Tyr 
1               5               


<210>  26
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala 
            20                  25                  30  


<210>  30
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2

<400>  30

Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2

<400>  31

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2

<400>  32

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  33
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3

<400>  33

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  34
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3

<400>  34

Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  35
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3

<400>  35

Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  36
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3

<400>  36

Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala Tyr Leu Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  37
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4

<400>  37

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleProSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaIle

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = HisSer

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = IleLeu

<400>  38

Arg Ala Ser Glu Ser Val Ser Val Xaa Gly Xaa Xaa Xaa Xaa His 
1               5                   10                  15  


<210>  39
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AlaSer

<400>  39

Leu Gly Xaa Asn Arg Xaa Xaa 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = IleArg

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = HisThr

<400>  40

Leu Gln Ser Arg Xaa Phe Pro Arg Xaa 
1               5                   


<210>  41
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = GlySer

<400>  41

Trp Ile Asn Thr Glu Thr Arg Glu Pro Xaa Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Xaa 
    


<210>  42
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = SerThr

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Xaa Phe Ala 
            20                  25                  30  


<210>  43
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = IleMet

<400>  43

Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Xaa Gly 
1               5                   10                  


<210>  44
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AlaIleVal

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = AlaSer

<400>  44

Arg Phe Xaa Phe Xaa Leu Xaa Thr Ser Xaa Ser Thr Ala Tyr Leu Xaa 
1               5                   10                  15      


Xaa Ser Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  45
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = IleProSer

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = AlaIle

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = HisSer

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = AlaPro

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = IleArg

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = HisThr

<400>  45

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Xaa 
            20                  25                  30          


Gly Xaa Xaa Xaa Xaa His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Xaa Asn Arg Xaa Xaa Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Xaa Phe Pro Arg Xaa Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  46
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = IleMet

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = AlaIleVal

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaSer

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Xaa Phe Ala Asp Tyr 
            20                  25                  30          


Thr Ile Asn Trp Val Arg Gln Ala Xaa Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Xaa Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Xaa Arg Phe Xaa Phe Xaa Leu Xaa Thr Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Xaa Xaa Ser Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  47
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  48
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  49
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-01 scFv

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  50
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-02 scFv

<400>  50

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ser 
            20                  25                  30          


Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Ser Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  51
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-15 scFv

<400>  51

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ser 
            20                  25                  30          


Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Gln Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Ser Arg Phe Val Phe Ser Leu Asp Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  52
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-17 scFv

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ser 
            20                  25                  30          


Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  53
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-19 scFv

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  54
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-20 scFv

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala Ala Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  55
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-22 scFv

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  56
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-23 scFv

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Val Pro 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp 
145                 150                 155                 160 


Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Thr Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  57
<211>  231
<212>  PRT
<213>  ࣨHomo sapiens

<400>  57

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  58
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  58

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  59
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ź

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  60
<211>  45
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8

<400>  60

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  61
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8Ĥṹ

<400>  61

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  62
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD137̼ṹ

<400>  62

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  63
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ

<400>  63

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  64
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-01 CAR

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  65
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-02 CAR

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ser Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Ser Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Ser Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  66
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-15 CAR

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ser Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Val Lys Gln Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Ser Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Thr Tyr Ala Tyr Asp Phe Arg Ser Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  67
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-17 CAR

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ser Gly Ile His Leu Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Thr Tyr Ala Tyr Asp Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  68
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-19 CAR

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Pro Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  69
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-20 CAR

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Pro Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Thr Tyr Ala Tyr Asp Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  70
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-22 CAR

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Pro Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  71
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-23 CAR

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Pro Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Thr Tyr Ala Tyr Asp Phe Arg Ser Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  72
<211>  490
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-10 CAR

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  73
<211>  1098
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  huBCMA-10-L6-Li CAR

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu 
                485                 490                 495     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ala Val 
            500                 505                 510         


Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu Leu Arg Ala Glu 
        515                 520                 525             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Pro Pro Thr Cys Ser Pro 
    530                 535                 540                 


Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile Asp Cys Ile Pro Val Ala 
545                 550                 555                 560 


Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu Asp His Ser Asp Glu Leu 
                565                 570                 575     


Asn Cys Pro Val Cys Ser Glu Ser Gln Phe Gln Cys Ala Ser Gly Gln 
            580                 585                 590         


Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly Asp Ala Asn Cys Gln Asp 
        595                 600                 605             


Lys Ser Asp Glu Lys Asn Cys Glu Val Leu Cys Leu Ile Asp Gln Phe 
    610                 615                 620                 


Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys His Lys Lys Cys Asp His 
625                 630                 635                 640 


Asn Val Asp Cys Ser Asp Lys Ser Asp Glu Leu Asp Cys Tyr Pro Thr 
                645                 650                 655     


Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr Val Gly Ser Val Ile Gly 
            660                 665                 670         


Val Ile Val Thr Ile Phe Val Ser Gly Thr Val Tyr Phe Ile Cys Gln 
        675                 680                 685             


Arg Met Leu Cys Pro Arg Met Lys Gly Asp Gly Glu Thr Met Thr Asn 
    690                 695                 700                 


Asp Tyr Val Val His Gly Pro Ala Ser Val Pro Leu Gly Tyr Val Pro 
705                 710                 715                 720 


His Pro Ser Ser Leu Ser Gly Ser Leu Pro Gly Met Ser Arg Gly Lys 
                725                 730                 735     


Ser Met Ile Ser Ser Leu Ser Ile Met Gly Gly Ser Ser Gly Pro Pro 
            740                 745                 750         


Tyr Asp Arg Ala His Val Thr Gly Ala Ser Ser Ser Ser Ser Ser Ser 
        755                 760                 765             


Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu Asn Pro Pro Pro Ser Pro 
    770                 775                 780                 


Ala Thr Glu Arg Ser His Tyr Thr Met Glu Phe Gly Tyr Ser Ser Asn 
785                 790                 795                 800 


Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr Arg Pro Tyr Ser Tyr Arg 
                805                 810                 815     


His Phe Ala Pro Pro Thr Thr Pro Cys Ser Thr Asp Val Cys Asp Ser 
            820                 825                 830         


Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser Val Ala Thr Ala Lys Gly 
        835                 840                 845             


Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu Pro Val Pro Pro Pro Pro 
    850                 855                 860                 


Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu Glu Asn Tyr Glu Ser Cys 
865                 870                 875                 880 


Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr Ser His His Leu Tyr Pro 
                885                 890                 895     


Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser Ala Thr Asn Phe Ser Leu 
            900                 905                 910         


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Trp 
        915                 920                 925             


Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu Phe Tyr Val 
    930                 935                 940                 


Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu Ile 
945                 950                 955                 960 


Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser Val 
                965                 970                 975     


Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His 
            980                 985                 990         


Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala Val Tyr Gln 
        995                 1000                1005            


Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile Ser Asn 
    1010                1015                1020                


Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys 
1025                1030                1035                1040


Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu 
                1045                1050                1055    


Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu 
            1060                1065                1070        


Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln Leu Asp Leu 
        1075                1080                1085            


Ser Pro Gly Cys His His His His His His 
    1090                1095            


<210>  74
<211>  1098
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-22-L6-Li CAR

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Pro Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Arg Phe Pro Arg His Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Ala Asp Tyr Thr Ile Asn Trp Val Arg Gln Ala Thr Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Thr Phe Thr Leu Asn Thr 
    210                 215                 220                 


Ser Ile Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Arg Tyr Val Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu 
                485                 490                 495     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ala Val 
            500                 505                 510         


Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu Leu Arg Ala Glu 
        515                 520                 525             


Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Pro Pro Thr Cys Ser Pro 
    530                 535                 540                 


Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile Asp Cys Ile Pro Val Ala 
545                 550                 555                 560 


Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu Asp His Ser Asp Glu Leu 
                565                 570                 575     


Asn Cys Pro Val Cys Ser Glu Ser Gln Phe Gln Cys Ala Ser Gly Gln 
            580                 585                 590         


Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly Asp Ala Asn Cys Gln Asp 
        595                 600                 605             


Lys Ser Asp Glu Lys Asn Cys Glu Val Leu Cys Leu Ile Asp Gln Phe 
    610                 615                 620                 


Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys His Lys Lys Cys Asp His 
625                 630                 635                 640 


Asn Val Asp Cys Ser Asp Lys Ser Asp Glu Leu Asp Cys Tyr Pro Thr 
                645                 650                 655     


Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr Val Gly Ser Val Ile Gly 
            660                 665                 670         


Val Ile Val Thr Ile Phe Val Ser Gly Thr Val Tyr Phe Ile Cys Gln 
        675                 680                 685             


Arg Met Leu Cys Pro Arg Met Lys Gly Asp Gly Glu Thr Met Thr Asn 
    690                 695                 700                 


Asp Tyr Val Val His Gly Pro Ala Ser Val Pro Leu Gly Tyr Val Pro 
705                 710                 715                 720 


His Pro Ser Ser Leu Ser Gly Ser Leu Pro Gly Met Ser Arg Gly Lys 
                725                 730                 735     


Ser Met Ile Ser Ser Leu Ser Ile Met Gly Gly Ser Ser Gly Pro Pro 
            740                 745                 750         


Tyr Asp Arg Ala His Val Thr Gly Ala Ser Ser Ser Ser Ser Ser Ser 
        755                 760                 765             


Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu Asn Pro Pro Pro Ser Pro 
    770                 775                 780                 


Ala Thr Glu Arg Ser His Tyr Thr Met Glu Phe Gly Tyr Ser Ser Asn 
785                 790                 795                 800 


Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr Arg Pro Tyr Ser Tyr Arg 
                805                 810                 815     


His Phe Ala Pro Pro Thr Thr Pro Cys Ser Thr Asp Val Cys Asp Ser 
            820                 825                 830         


Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser Val Ala Thr Ala Lys Gly 
        835                 840                 845             


Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu Pro Val Pro Pro Pro Pro 
    850                 855                 860                 


Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu Glu Asn Tyr Glu Ser Cys 
865                 870                 875                 880 


Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr Ser His His Leu Tyr Pro 
                885                 890                 895     


Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser Ala Thr Asn Phe Ser Leu 
            900                 905                 910         


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Trp 
        915                 920                 925             


Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu Phe Tyr Val 
    930                 935                 940                 


Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu Ile 
945                 950                 955                 960 


Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser Val 
                965                 970                 975     


Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His 
            980                 985                 990         


Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala Val Tyr Gln 
        995                 1000                1005            


Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile Ser Asn 
    1010                1015                1020                


Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys 
1025                1030                1035                1040


Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu 
                1045                1050                1055    


Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu 
            1060                1065                1070        


Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln Leu Asp Leu 
        1075                1080                1085            


Ser Pro Gly Cys His His His His His His 
    1090                1095            


<210>  75
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  75
gaaatcgttc tgacccagag tccagcgacg ctgagtctga gtccgggtga acgcgcgacg       60

ctgagttgcc gtgccagcga aagcgttagc gtgattggcg cccatctgat ccactggtac      120

cagcagaaac cgggccaagc cccacgtctg ctgatctatc tgggacgcaa tcgggcggcc      180

ggcattccag cccgctttag cggcagcggt agcggtaccg attttacgct gaccatcagc      240

agtctggagc cagaagatgc cgccatctac tactgtctgc agagccgcat cttcccacgc      300

accttcggcc aaggcaccaa actggaaatc aag                                   333


<210>  76
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  76
gaaatcgttc tgacccagag tccagcgacg ctgagtctga gtccgggtga acgcgcgacg       60

ctgagttgcc gtgccagcga aagcgttagc gtgagtggca ttcacttact ccactggtac      120

cagcagaaac cgggccaagc cccacgtctg ctgatctatc tgggacgcaa tcgggcggcc      180

ggcattccag cccgctttag cggcagcggt agcggtaccg attttacgct gaccatcagc      240

agtctggagc cagaagatgc cgccatctac tactgtttac agagcagaag gtttcctcga      300

cacttcggcc aaggtaccaa actggaaatc aag                                   333


<210>  77
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  77
gaaatcgttc tgacccagag tccagcgacg ctgagtctga gtccgggtga acgcgcgacg       60

ctgagttgcc gtgccagcga aagcgttagc gtgcctggca tatctttcat ccactggtac      120

cagcagaaac cgggccaagc cccacgtctg ctgatctatc tgggacgcaa tcgggcggcc      180

ggcattccag cccgctttag cggcagcggt agcggtaccg attttacgct gaccatcagc      240

agtctggagc cagaagatgc cgccatctac tactgtttac agagcagaag gtttcctcga      300

cacttcggcc aaggtaccaa actggaaatc aag                                   333


<210>  78
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  78
gaaatcgttc tgacccagag tccagcgacg ctgagtctga gtccgggtga acgcgcgacg       60

ctgagttgcc gtgccagcga aagcgttagc gtgcctggca tatctttcat ccactggtac      120

cagcagaaac cgggccaagc cccacgtctg ctgatctatc tgggcagcaa tcgaccatcc      180

ggcattccag cccgctttag cggcagcggt agcggtaccg attttacgct gaccatcagc      240

agtctggagc cagaagatgc cgccatctac tactgtttac agagcagaag gtttcctcga      300

cacttcggcc aaggcaccaa actggaaatc aag                                   333


<210>  79
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  79
gacatcgtgc tgacccagag ccccgcttct ttagctgtgt ctttaggaga gagggccacc       60

atcaattgtc gtgcctccga gtccgtgtcc gtgattggcg cccatttaat ccactggtac      120

cagcagaaac ccggccagcc ccccaagctg ctgatctatt tagccagcaa tctggagacc      180

ggcgtgcccg ccagatttag cggaagcggc tccggcaccg attttacttt aaccatttcc      240

tctttacaag ctgaggacgc cgccatctac tactgtttac agagcagaat ctttcctcgt      300

accttcggcc aaggtaccaa gctggaaatc aag                                   333


<210>  80
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  80
caagttcagc tcgtgcagag cggctccgag ctgaagaagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata caccttcgcc gattacacca tcaactgggt tcgtcaagct      120

accggtcaag gtctggagtg gatgggctgg atcaacaccg aaaccagaga gcccgcctat      180

gcctacgact tcagaggtcg tttcgtgttc tctttagaca caagcgtgag caccgcctat      240

ttacagatca gctctttaaa ggccgaggat accgccgtgt actactgcgc tcgtgacatc      300

agatacgtga tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  81
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  81
caagttcagc tcgtgcagag cggctccgag ctgaagaagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata cagcttcgcc gattacacca tcaactgggt tcgtcaagct      120

cccggtcaag gtctggagtg gataggctgg atcaacaccg aaaccagaga gcccgcctat      180

gcctacgact tcagaagtcg tttcgtgttc tctttagaca caagcgcgag caccgcctat      240

ttacagatca gctctttaaa ggccgaggat accgccgtgt actactgcgc tcgtgacatc      300

agatacgtga tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  82
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  82
caagttcagc tcgtgcagag cggctccgag gtgaagcagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata cagcttcgcc gattacacca tcaactgggt tcgtcaagct      120

cccggtcaag gtctggagtg gatgggctgg atcaacaccg aaaccagaga gcccacctat      180

gcctacgact tcagaagtcg tttcgtgttc tctttagaca caagcgcgag caccgcctat      240

ttagagctca gctctttaag gtccgaggat accgccgtgt actactgcgc tcgtgacatc      300

agatacgtga tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  83
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  83
caagttcagc tcgtgcagag cggcgccgag gtgaagaagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata caccttcgcc gattacacca tcaactgggt tcgtcaagct      120

accggtcaag gtctggagtg gatgggctgg atcaacaccg aaaccagaga gcccacctat      180

gcctacgact tcagaagtcg tttcacgttc actttaaaca caagcatcag caccgcctat      240

ttagagctca gctctttaag gtccgaggat accgccgtgt actactgcgc tcgtgacatc      300

agatacgtga tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  84
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  84
caagttcagc tcgtgcagag cggcgccgag gtgaagaagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata caccttcgcc gattacacca tcaactgggt tcgtcaagct      120

accggtcaag gtctggagtg gatgggctgg atcaacaccg aaaccagaga gcccgcctat      180

gcctacgact tcagaggtcg tttcacgttc actttaaaca caagcatcag caccgcctat      240

ttagagctca gctctttaag gtccgaggat accgccgtgt actactgcgc tcgtgacatc      300

agatacgtga tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  85
<211>  351
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  85
caagttcagc tcgtgcagag cggctccgag ctgaagaagc ccggcgcttc cgtgaaggtg       60

agctgcaagg ccagcggata caccttcacc gactactcca tcaactgggt tcgtcaagct      120

cccggtcaag gtctggagtg gatgggctgg atcaacaccg aaaccagaga gcccgcctat      180

gcctacgact tcagaggtcg tttcgtgttc tctttagaca caagcgtgag caccgcctat      240

ttacagatca gctctttaaa ggccgaggat accgccgtgt actactgcgc tcgtgactac      300

agctacgcca tggactactg gggccaaggt acactggtga ccgtgtccag c               351


<210>  86
<211>  54
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ĺ

<400>  86
ggatccacca gcggctccgg aaagcccggt tccggagagg gcagcacaaa gggc             54


<210>  87
<211>  51
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  87
cctctggctc tgctgctgca cgccgcaaga cctgaaatcg ttctgaccca g                51


<210>  88
<211>  58
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  88
tgggcgccgg tgttggtggt cgcggcgctg gcgtcgtggt gctggacacg gtcaccag         58


<210>  89
<211>  735
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ź-CD8-CD8Ĥ-CD137̼ṹ-CD3ưźŴṹ

<400>  89
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      120

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      180

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt      240

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata      300

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc      360

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca      420

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga      480

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      540

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      600

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc      660

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc      720

ctgccccctc gctaa                                                       735


<210>  90
<211>  63
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ź

<400>  90
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cct                                                                     63


<210>  91
<211>  135
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8

<400>  91
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  92
<211>  72
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD8Ĥṹ

<400>  92
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  93
<211>  126
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD137̼ṹ

<400>  93
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  94
<211>  339
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD3ưźŴṹ

<400>  94
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  95
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-01 CAR

<400>  95
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgattg gcgcccatct gatccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtc tgcagagccg catcttccca      360

cgcaccttcg gccaaggcac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggctccgag      480

ctgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcgtgttc      660

tctttagaca caagcgtgag caccgcctat ttacagatca gctctttaaa ggccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  96
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-02 CAR

<400>  96
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgagtg gcattcactt actccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggtac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggctccgag      480

ctgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata cagcttcgcc      540

gattacacca tcaactgggt tcgtcaagct cccggtcaag gtctggagtg gataggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaagtcg tttcgtgttc      660

tctttagaca caagcgcgag caccgcctat ttacagatca gctctttaaa ggccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  97
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-15 CAR

<400>  97
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgagtg gcattcactt actccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggtac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggctccgag      480

gtgaagcagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata cagcttcgcc      540

gattacacca tcaactgggt tcgtcaagct cccggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccacctat gcctacgact tcagaagtcg tttcgtgttc      660

tctttagaca caagcgcgag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  98
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-17 CAR

<400>  98
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgagtg gcattcactt actccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggtac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccacctat gcctacgact tcagaagtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  99
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-19 CAR

<400>  99
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgcctg gcatatcttt catccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggtac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  100
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-20 CAR

<400>  100
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgcctg gcatatcttt catccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggacg caatcgggcg      240

gccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggtac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccacctat gcctacgact tcagaagtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  101
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-22 CAR

<400>  101
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgcctg gcatatcttt catccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggcag caatcgacca      240

tccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggcac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  102
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-23 CAR

<400>  102
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgcctg gcatatcttt catccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggcag caatcgacca      240

tccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggcac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccacctat gcctacgact tcagaagtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  103
<211>  1473
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-10 CAR

<400>  103
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgacatcg tgctgaccca gagccccgct tctttagctg tgtctttagg agagagggcc      120

accatcaatt gtcgtgcctc cgagtccgtg tccgtgattg gcgcccattt aatccactgg      180

taccagcaga aacccggcca gccccccaag ctgctgatct atttagccag caatctggag      240

accggcgtgc ccgccagatt tagcggaagc ggctccggca ccgattttac tttaaccatt      300

tcctctttac aagctgagga cgccgccatc tactactgtt tacagagcag aatctttcct      360

cgtaccttcg gccaaggtac caagctggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggctccgag      480

ctgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcacc      540

gactactcca tcaactgggt tcgtcaagct cccggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcgtgttc      660

tctttagaca caagcgtgag caccgcctat ttacagatca gctctttaaa ggccgaggat      720

accgccgtgt actactgcgc tcgtgactac agctacgcca tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc taa                                  1473


<210>  104
<211>  3294
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  huBCMA-10-L6-Li CAR

<400>  104
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgacatcg tgctgaccca gagccccgct tctttagctg tgtctttagg agagagggcc      120

accatcaatt gtcgtgcctc cgagtccgtg tccgtgattg gcgcccattt aatccactgg      180

taccagcaga aacccggcca gccccccaag ctgctgatct atttagccag caatctggag      240

accggcgtgc ccgccagatt tagcggaagc ggctccggca ccgattttac tttaaccatt      300

tcctctttac aagctgagga cgccgccatc tactactgtt tacagagcag aatctttcct      360

cgtaccttcg gccaaggtac caagctggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggctccgag      480

ctgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcacc      540

gactactcca tcaactgggt tcgtcaagct cccggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcgtgttc      660

tctttagaca caagcgtgag caccgcctat ttacagatca gctctttaaa ggccgaggat      720

accgccgtgt actactgcgc tcgtgactac agctacgcca tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc gagggcagag gaagtcttct aacatgcggt     1500

gacgtggagg agaatcccgg ccctatgggg gccgtcctga ggagcctcct ggcctgcagc     1560

ttctgtgtgc tcctgagagc ggagcagaaa ctcatctctg aagaggatct ggaacctcca     1620

acatgttctc ctcagcagtt tacttgtttc acgggggaaa ttgactgtat ccctgtggct     1680

tggcggtgcg atgggtttac tgaatgtgaa gaccacagtg atgaactcaa ttgtcctgta     1740

tgctcagagt cccagttcca gtgtgccagt gggcagtgta ttgatggtgc cctccgatgc     1800

aatggagatg caaactgcca ggacaaatca gatgagaaga actgtgaagt gctttgttta     1860

attgatcagt tccgctgtgc caatggtcag tgcattggaa agcacaagaa gtgtgatcat     1920

aatgtggatt gcagtgacaa gtcagatgaa ctggattgtt atccgactga agaaccagca     1980

ccacaggcca ccaatacagt tggttctgtt attggcgtaa ttgtcaccat ttttgtgtct     2040

ggaactgtat actttatctg ccagaggatg ttgtgtccac gtatgaaggg agatggggaa     2100

actatgacta atgactatgt agttcatgga ccagcttctg tgcctcttgg ttatgtgcca     2160

cacccaagtt ctttgtcagg atctcttcca ggaatgtctc gaggtaaatc aatgatcagc     2220

tccctcagta tcatgggggg aagcagtgga cccccctatg accgagccca tgttacagga     2280

gcatcatcaa gtagttcttc aagcaccaaa ggcacttact tccctgcaat tttgaaccct     2340

ccaccatccc cagccacaga gcgatcacat tacactatgg aatttggata ttcttcaaac     2400

agtccttcca ctcataggtc atacagctac aggccatata gctaccggca ctttgcaccc     2460

cccaccacac cctgcagcac agatgtttgt gacagtgact atgctcctag tcggagaatg     2520

acctcagtgg caacagccaa gggctatacc agtgacttga actatgattc agaacctgtg     2580

cccccacctc ccacaccccg aagccaatac ttgtcagcag aggagaacta tgaaagctgc     2640

ccaccttctc catacacaga gaggagctat tctcatcacc tctacccacc gccaccctct     2700

ccctgtacag actcctccgc caccaatttt agcctgctga aacaggccgg agacgtggag     2760

gaaaaccccg gccccatgca ttggggaacc ctgtgcggat tcttgtggct ttggccctat     2820

cttttctatg tccaagctgt gcccatccaa aaagtccaag atgacaccaa aaccctcatc     2880

aagacaattg tcaccaggat caatgacatt tcacacacgc agtcagtctc ctccaaacag     2940

aaagtcaccg gtttggactt cattcctggg ctccacccca tcctgacctt atccaagatg     3000

gaccagacac tggcagtcta ccaacagatc ctcaccagta tgccttccag aaacgtgatc     3060

caaatatcca acgacctgga gaacctccgg gatcttcttc acgtgctggc cttctctaag     3120

agctgccact tgccctgggc cagtggcctg gagaccttgg acagcctggg gggtgtcctg     3180

gaagcttcag gctactccac agaggtggtg gccctgagca ggctgcaggg gtctctgcag     3240

gacatgctgt ggcagctgga cctcagccct gggtgccacc atcaccacca tcac           3294


<210>  105
<211>  3294
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  hBCMA-22-L6-Li CAR

<400>  105
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cctgaaatcg ttctgaccca gagtccagcg acgctgagtc tgagtccggg tgaacgcgcg      120

acgctgagtt gccgtgccag cgaaagcgtt agcgtgcctg gcatatcttt catccactgg      180

taccagcaga aaccgggcca agccccacgt ctgctgatct atctgggcag caatcgacca      240

tccggcattc cagcccgctt tagcggcagc ggtagcggta ccgattttac gctgaccatc      300

agcagtctgg agccagaaga tgccgccatc tactactgtt tacagagcag aaggtttcct      360

cgacacttcg gccaaggcac caaactggaa atcaagggat ccaccagcgg ctccggaaag      420

cccggttccg gagagggcag cacaaagggc caagttcagc tcgtgcagag cggcgccgag      480

gtgaagaagc ccggcgcttc cgtgaaggtg agctgcaagg ccagcggata caccttcgcc      540

gattacacca tcaactgggt tcgtcaagct accggtcaag gtctggagtg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctat gcctacgact tcagaggtcg tttcacgttc      660

actttaaaca caagcatcag caccgcctat ttagagctca gctctttaag gtccgaggat      720

accgccgtgt actactgcgc tcgtgacatc agatacgtga tggactactg gggccaaggt      780

acactggtga ccgtgtccag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc gagggcagag gaagtcttct aacatgcggt     1500

gacgtggagg agaatcccgg ccctatgggg gccgtcctga ggagcctcct ggcctgcagc     1560

ttctgtgtgc tcctgagagc ggagcagaaa ctcatctctg aagaggatct ggaacctcca     1620

acatgttctc ctcagcagtt tacttgtttc acgggggaaa ttgactgtat ccctgtggct     1680

tggcggtgcg atgggtttac tgaatgtgaa gaccacagtg atgaactcaa ttgtcctgta     1740

tgctcagagt cccagttcca gtgtgccagt gggcagtgta ttgatggtgc cctccgatgc     1800

aatggagatg caaactgcca ggacaaatca gatgagaaga actgtgaagt gctttgttta     1860

attgatcagt tccgctgtgc caatggtcag tgcattggaa agcacaagaa gtgtgatcat     1920

aatgtggatt gcagtgacaa gtcagatgaa ctggattgtt atccgactga agaaccagca     1980

ccacaggcca ccaatacagt tggttctgtt attggcgtaa ttgtcaccat ttttgtgtct     2040

ggaactgtat actttatctg ccagaggatg ttgtgtccac gtatgaaggg agatggggaa     2100

actatgacta atgactatgt agttcatgga ccagcttctg tgcctcttgg ttatgtgcca     2160

cacccaagtt ctttgtcagg atctcttcca ggaatgtctc gaggtaaatc aatgatcagc     2220

tccctcagta tcatgggggg aagcagtgga cccccctatg accgagccca tgttacagga     2280

gcatcatcaa gtagttcttc aagcaccaaa ggcacttact tccctgcaat tttgaaccct     2340

ccaccatccc cagccacaga gcgatcacat tacactatgg aatttggata ttcttcaaac     2400

agtccttcca ctcataggtc atacagctac aggccatata gctaccggca ctttgcaccc     2460

cccaccacac cctgcagcac agatgtttgt gacagtgact atgctcctag tcggagaatg     2520

acctcagtgg caacagccaa gggctatacc agtgacttga actatgattc agaacctgtg     2580

cccccacctc ccacaccccg aagccaatac ttgtcagcag aggagaacta tgaaagctgc     2640

ccaccttctc catacacaga gaggagctat tctcatcacc tctacccacc gccaccctct     2700

ccctgtacag actcctccgc caccaatttt agcctgctga aacaggccgg agacgtggag     2760

gaaaaccccg gccccatgca ttggggaacc ctgtgcggat tcttgtggct ttggccctat     2820

cttttctatg tccaagctgt gcccatccaa aaagtccaag atgacaccaa aaccctcatc     2880

aagacaattg tcaccaggat caatgacatt tcacacacgc agtcagtctc ctccaaacag     2940

aaagtcaccg gtttggactt cattcctggg ctccacccca tcctgacctt atccaagatg     3000

gaccagacac tggcagtcta ccaacagatc ctcaccagta tgccttccag aaacgtgatc     3060

caaatatcca acgacctgga gaacctccgg gatcttcttc acgtgctggc cttctctaag     3120

agctgccact tgccctgggc cagtggcctg gagaccttgg acagcctggg gggtgtcctg     3180

gaagcttcag gctactccac agaggtggtg gccctgagca ggctgcaggg gtctctgcag     3240

gacatgctgt ggcagctgga cctcagccct gggtgccacc atcaccacca tcac           3294


<210>  106
<211>  1824
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  L6-Li 

<400>  106
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccctatgggg       60

gccgtcctga ggagcctcct ggcctgcagc ttctgtgtgc tcctgagagc ggagcagaaa      120

ctcatctctg aagaggatct ggaacctcca acatgttctc ctcagcagtt tacttgtttc      180

acgggggaaa ttgactgtat ccctgtggct tggcggtgcg atgggtttac tgaatgtgaa      240

gaccacagtg atgaactcaa ttgtcctgta tgctcagagt cccagttcca gtgtgccagt      300

gggcagtgta ttgatggtgc cctccgatgc aatggagatg caaactgcca ggacaaatca      360

gatgagaaga actgtgaagt gctttgttta attgatcagt tccgctgtgc caatggtcag      420

tgcattggaa agcacaagaa gtgtgatcat aatgtggatt gcagtgacaa gtcagatgaa      480

ctggattgtt atccgactga agaaccagca ccacaggcca ccaatacagt tggttctgtt      540

attggcgtaa ttgtcaccat ttttgtgtct ggaactgtat actttatctg ccagaggatg      600

ttgtgtccac gtatgaaggg agatggggaa actatgacta atgactatgt agttcatgga      660

ccagcttctg tgcctcttgg ttatgtgcca cacccaagtt ctttgtcagg atctcttcca      720

ggaatgtctc gaggtaaatc aatgatcagc tccctcagta tcatgggggg aagcagtgga      780

cccccctatg accgagccca tgttacagga gcatcatcaa gtagttcttc aagcaccaaa      840

ggcacttact tccctgcaat tttgaaccct ccaccatccc cagccacaga gcgatcacat      900

tacactatgg aatttggata ttcttcaaac agtccttcca ctcataggtc atacagctac      960

aggccatata gctaccggca ctttgcaccc cccaccacac cctgcagcac agatgtttgt     1020

gacagtgact atgctcctag tcggagaatg acctcagtgg caacagccaa gggctatacc     1080

agtgacttga actatgattc agaacctgtg cccccacctc ccacaccccg aagccaatac     1140

ttgtcagcag aggagaacta tgaaagctgc ccaccttctc catacacaga gaggagctat     1200

tctcatcacc tctacccacc gccaccctct ccctgtacag actcctccgc caccaatttt     1260

agcctgctga aacaggccgg agacgtggag gaaaaccccg gccccatgca ttggggaacc     1320

ctgtgcggat tcttgtggct ttggccctat cttttctatg tccaagctgt gcccatccaa     1380

aaagtccaag atgacaccaa aaccctcatc aagacaattg tcaccaggat caatgacatt     1440

tcacacacgc agtcagtctc ctccaaacag aaagtcaccg gtttggactt cattcctggg     1500

ctccacccca tcctgacctt atccaagatg gaccagacac tggcagtcta ccaacagatc     1560

ctcaccagta tgccttccag aaacgtgatc caaatatcca acgacctgga gaacctccgg     1620

gatcttcttc acgtgctggc cttctctaag agctgccact tgccctgggc cagtggcctg     1680

gagaccttgg acagcctggg gggtgtcctg gaagcttcag gctactccac agaggtggtg     1740

gccctgagca ggctgcaggg gtctctgcag gacatgctgt ggcagctgga cctcagccct     1800

gggtgccacc atcaccacca tcac                                            1824


<210>  107
<211>  608
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L6-Li 

<400>  107

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys 
            20                  25                  30          


Val Leu Leu Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
        35                  40                  45              


Pro Pro Thr Cys Ser Pro Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile 
    50                  55                  60                  


Asp Cys Ile Pro Val Ala Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu 
65                  70                  75                  80  


Asp His Ser Asp Glu Leu Asn Cys Pro Val Cys Ser Glu Ser Gln Phe 
                85                  90                  95      


Gln Cys Ala Ser Gly Gln Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly 
            100                 105                 110         


Asp Ala Asn Cys Gln Asp Lys Ser Asp Glu Lys Asn Cys Glu Val Leu 
        115                 120                 125             


Cys Leu Ile Asp Gln Phe Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys 
    130                 135                 140                 


His Lys Lys Cys Asp His Asn Val Asp Cys Ser Asp Lys Ser Asp Glu 
145                 150                 155                 160 


Leu Asp Cys Tyr Pro Thr Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr 
                165                 170                 175     


Val Gly Ser Val Ile Gly Val Ile Val Thr Ile Phe Val Ser Gly Thr 
            180                 185                 190         


Val Tyr Phe Ile Cys Gln Arg Met Leu Cys Pro Arg Met Lys Gly Asp 
        195                 200                 205             


Gly Glu Thr Met Thr Asn Asp Tyr Val Val His Gly Pro Ala Ser Val 
    210                 215                 220                 


Pro Leu Gly Tyr Val Pro His Pro Ser Ser Leu Ser Gly Ser Leu Pro 
225                 230                 235                 240 


Gly Met Ser Arg Gly Lys Ser Met Ile Ser Ser Leu Ser Ile Met Gly 
                245                 250                 255     


Gly Ser Ser Gly Pro Pro Tyr Asp Arg Ala His Val Thr Gly Ala Ser 
            260                 265                 270         


Ser Ser Ser Ser Ser Ser Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu 
        275                 280                 285             


Asn Pro Pro Pro Ser Pro Ala Thr Glu Arg Ser His Tyr Thr Met Glu 
    290                 295                 300                 


Phe Gly Tyr Ser Ser Asn Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr 
305                 310                 315                 320 


Arg Pro Tyr Ser Tyr Arg His Phe Ala Pro Pro Thr Thr Pro Cys Ser 
                325                 330                 335     


Thr Asp Val Cys Asp Ser Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser 
            340                 345                 350         


Val Ala Thr Ala Lys Gly Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu 
        355                 360                 365             


Pro Val Pro Pro Pro Pro Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu 
    370                 375                 380                 


Glu Asn Tyr Glu Ser Cys Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr 
385                 390                 395                 400 


Ser His His Leu Tyr Pro Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser 
                405                 410                 415     


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
            420                 425                 430         


Pro Gly Pro Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp 
        435                 440                 445             


Pro Tyr Leu Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp 
    450                 455                 460                 


Asp Thr Lys Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile 
465                 470                 475                 480 


Ser His Thr Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp 
                485                 490                 495     


Phe Ile Pro Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln 
            500                 505                 510         


Thr Leu Ala Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn 
        515                 520                 525             


Val Ile Gln Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His 
    530                 535                 540                 


Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu 
545                 550                 555                 560 


Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser 
                565                 570                 575     


Thr Glu Val Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met 
            580                 585                 590         


Leu Trp Gln Leu Asp Leu Ser Pro Gly Cys His His His His His His 
        595                 600                 605             

