               SEQUENCE LISTING

<110> Tigen Pharma SA

<120> Single Vessel Expansion of Lymphocytes

<130> AE1570 PCT BS

<150> EP21 171 565.1
<151> 2021-04-30

<160> 102

<170> BiSSAP 1.3.6

<210> 1
<211> 133
<212> PRT
<213> Homo sapiens


<220> 
<223> OX40L

<400> 1
Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      
Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          
Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              
Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  
Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  
Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      
Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         
Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             
Glu Phe Cys Val Leu 
    130             

<210> 2
<211> 402
<212> DNA
<213> Homo sapiens


<220> 
<223> OX40L

<400> 2
atggtatcac atcggtatcc tcgaattcaa agtatcaaag tacaatttac cgaatataag      60

aaggagaaag gtttcatcct cacttcccaa aaggaggatg aaatcatgaa ggtgcagaac     120

aactcagtca tcatcaactg tgatgggttt tatctcatct ccctgaaggg ctacttctcc     180

caggaagtca acattagcct tcattaccag aaggatgagg agcccctctt ccaactgaag     240

aaggtcaggt ctgtcaactc cttgatggtg gcctctctga cttacaaaga caaagtctac     300

ttgaatgtga ccactgacaa tacctccctg gatgacttcc atgtgaatgg cggagaactg     360

attcttatcc atcaaaatcc tggtgaattc tgtgtccttt ga                        402


<210> 3
<211> 197
<212> PRT
<213> Mus musculus


<220> 
<223> OX40L

<400> 3
Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      
Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          
Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              
Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  
Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
65                  70                  75                  80  
Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
                85                  90                  95      
Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
            100                 105                 110         
Glu Val Lys Ile Asp His Phe Arg Glu Asp His Asn Pro Ile Ser Ile 
        115                 120                 125             
Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala Ser 
    130                 135                 140                 
Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp Thr 
145                 150                 155                 160 
Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val Gln 
                165                 170                 175     
Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr Val 
            180                 185                 190         
Asn Gln Val Pro Leu 
        195         

<210> 4
<211> 597
<212> DNA
<213> Mus musculus


<220> 
<223> OX40L

<400> 4
atggaagggg aaggggttca acccctggat gagaatctgg aaaacggatc aaggccaaga      60

ttcaagtgga agaagacgct aaggctggtg gtctctggga tcaagggagc agggatgctt     120

ctgtgcttca tctatgtctg cctgcaactc tcttcctctc cggcaaagga ccctccaatc     180

caaagactca gaggagcagt taccagatgt gaggatgggc aactattcat cagctcatac     240

aagaatgagt atcaaactat ggaggtgcag aacaattcgg ttgtcatcaa gtgcgatggg     300

ctttatatca tctacctgaa gggctccttt ttccaggagg tcaagattga ccttcatttc     360

cgggaggatc ataatcccat ctctattcca atgctgaacg atggtcgaag gattgtcttc     420

actgtggtgg cctctttggc tttcaaagat aaagtttacc tgactgtaaa tgctcctgat     480

actctctgcg aacacctcca gataaatgat ggggagctga ttgttgtcca gctaacgcct     540

ggatactgtg ctcctgaagg atcttaccac agcactgtga accaagtacc actgtga        597


<210> 5
<211> 254
<212> PRT
<213> Homo sapiens


<220> 
<223> 4-1BBL

<400> 5
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      
Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          
Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              
Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  
Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  
Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      
Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         
Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             
Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 
Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 
Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     
Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         
Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             
Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 
Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 
Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 

<210> 6
<211> 765
<212> DNA
<213> Homo sapiens


<220> 
<223> 4-1BBL

<400> 6
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc      60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg     120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc     180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat     240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt     300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg     360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc     420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc     480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct     540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag     600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc     660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg     720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                     765


<210> 7
<211> 309
<212> PRT
<213> Mus musculus


<220> 
<223> 4-1BBL

<400> 7
Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      
Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          
Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              
Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  
Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  
Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      
Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         
Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             
Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 
Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 
Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     
Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         
Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             
Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 
Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 
Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     
Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         
Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             
Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 
Asp Asn Pro Trp Glu 
305                 

<210> 8
<211> 930
<212> DNA
<213> Mus musculus


<220> 
<223> 4-1BBL

<400> 8
atggaccagc acacacttga tgtggaggat accgcggatg ccagacatcc agcaggtact      60

tcgtgcccct cggatgcggc gctcctcaga gataccgggc tcctcgcgga cgctgcgctc     120

ctctcagata ctgtgcgccc cacaaatgcc gcgctcccca cggatgctgc ctaccctgcg     180

gttaatgttc gggatcgcga ggccgcgtgg ccgcctgcac tgaacttctg ttcccgccac     240

ccaaagctct atggcctagt cgctttggtt ttgctgcttc tgatcgccgc ctgtgttcct     300

atcttcaccc gcaccgagcc tcggccagcg ctcacaatca ccacctcgcc caacctgggt     360

acccgagaga ataatgcaga ccaggtcacc cctgtttccc acattggctg ccccaacact     420

acacaacagg gctctcctgt gttcgccaag ctactggcta aaaaccaagc atcgttgtgc     480

aatacaactc tgaactggca cagccaagat ggagctggga gctcatacct atctcaaggt     540

ctgaggtacg aagaagacaa aaaggagttg gtggtagaca gtcccgggct ctactacgta     600

tttttggaac tgaagctcag tccaacattc acaaacacag gccacaaggt gcagggctgg     660

gtctctcttg ttttgcaagc aaagcctcag gtagatgact ttgacaactt ggccctgaca     720

gtggaactgt tcccttgctc catggagaac aagttagtgg accgttcctg gagtcaactg     780

ttgctcctga aggctggcca ccgcctcagt gtgggtctga gggcttatct gcatggagcc     840

caggatgcat acagagactg ggagctgtct tatcccaaca ccaccagctt tggactcttt     900

cttgtgaaac ccgacaaccc atgggaatga                                      930


<210> 9
<211> 285
<212> PRT
<213> Homo sapiens


<220> 
<223> CD80

<400> 9
Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala Leu 
1               5                   10                  15      
Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp Ser 
            20                  25                  30          
Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu Pro 
        35                  40                  45              
Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly Lys 
    50                  55                  60                  
Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys Thr 
65                  70                  75                  80  
Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro Ala 
                85                  90                  95      
Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu Ile 
            100                 105                 110         
Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala Thr 
        115                 120                 125             
Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala Val 
    130                 135                 140                 
Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr Arg 
145                 150                 155                 160 
Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr Gly 
                165                 170                 175     
Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly Gly 
            180                 185                 190         
Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met Ala 
        195                 200                 205             
Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys Asp 
    210                 215                 220                 
Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg Leu 
225                 230                 235                 240 
Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln Glu 
                245                 250                 255     
Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn Leu 
            260                 265                 270         
Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp 
        275                 280                 285 

<210> 10
<211> 858
<212> DNA
<213> Homo sapiens


<220> 
<223> CD80

<400> 10
atggaggtgc cgccaccggc accgcggagc tttctctgta gagcattgtg cctatttccc      60

cgagtctttg ctgccgaagc tgtgactgcc gattcggaag tccttgagga gcgtcagaag     120

cggcttccct acgtcccaga gccctattac ccggaatctg gatgggaccg cctccgggag     180

ctgtttggca aagatgaaca gcagagaatt tcaaaggacc ttgctaatat ctgtaagacg     240

gcagctacag caggcatcat tggctgggtg tatgggggaa taccagcttt tattcatgct     300

aaacaacaat acattgagca gagccaggca gaaatttatc ataaccggtt tgatgctgtg     360

caatctgcac atcgtgctgc cacacgaggc ttcattcgtt atggctggcg ctggggttgg     420

agaactgcag tgtttgtgac tatattcaac acagtgaaca ctagtctgaa tgtataccga     480

aataaagatg ccttaagcca ttttgtaatt gcaggagctg tcacgggaag tctttttagg     540

ataaacgtag gcctgcgtgg cctggtggct ggtggcataa ttggagcctt gctgggcact     600

cctgtaggag gcctgctgat ggcatttcag aagtactctg gtgagactgt tcaggaaaga     660

aaacagaagg atcgaaaggc actccatgag ctaaaactgg aagagtggaa aggcagacta     720

caagttactg agcacctccc tgagaaaatt gaaagtagtt tacaggaaga tgaacctgag     780

aatgatgcta agaaaattga agcactgcta aaccttccta gaaacccttc agtaatagat     840

aaacaagaca aggactga                                                   858


<210> 11
<211> 306
<212> PRT
<213> Mus musculus


<220> 
<223> CD80

<400> 11
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      
Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          
Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              
Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  
Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  
Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      
Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         
Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             
Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 
Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 
Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     
Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         
Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             
Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 
Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 
Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     
Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         
Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             
Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 
Phe Leu 
305     

<210> 12
<211> 918
<212> DNA
<213> Mus musculus


<220> 
<223> CD80

<400> 12
atggcttgca attgtcagtt gatgcaggat acaccactcc tcaagtttcc atgtccaagg      60

ctcattcttc tctttgtgct gctgattcgt ctttcacaag tgtcttcaga tgttgatgaa     120

caactgtcca agtcagtgaa agataaggta ttgctgcctt gccgttacaa ctctcctcat     180

gaagatgagt ctgaagaccg aatctactgg caaaaacatg acaaagtggt gctgtctgtc     240

attgctggga aactaaaagt gtggcccgag tataagaacc ggactttata tgacaacact     300

acctactctc ttatcatcct gggcctggtc ctttcagacc ggggcacata cagctgtgtc     360

gttcaaaaga aggaaagagg aacgtatgaa gttaaacact tggctttagt aaagttgtcc     420

atcaaagctg acttctctac ccccaacata actgagtctg gaaacccatc tgcagacact     480

aaaaggatta cctgctttgc ttccgggggt ttcccaaagc ctcgcttctc ttggttggaa     540

aatggaagag aattacctgg catcaatacg acaatttccc aggatcctga atctgaattg     600

tacaccatta gtagccaact agatttcaat acgactcgca accacaccat taagtgtctc     660

attaaatatg gagatgctca cgtgtcagag gacttcacct gggaaaaacc cccagaagac     720

cctcctgata gcaagaacac acttgtgctc tttggggcag gattcggcgc agtaataaca     780

gtcgtcgtca tcgttgtcat catcaaatgc ttctgtaagc acagaagctg tttcagaaga     840

aatgaggcaa gcagagaaac aaacaacagc cttaccttcg ggcctgaaga agcattagct     900

gaacagaccg tcttcctt                                                   918


<210> 13
<211> 247
<212> PRT
<213> Homo sapiens


<220> 
<223> CD86

<400> 13
Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His 
1               5                   10                  15      
Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
            20                  25                  30          
Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
        35                  40                  45              
Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
    50                  55                  60                  
Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly 
65                  70                  75                  80  
Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser 
                85                  90                  95      
Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr 
            100                 105                 110         
Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
        115                 120                 125             
Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg 
    130                 135                 140                 
Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro 
145                 150                 155                 160 
Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile 
                165                 170                 175     
Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys 
            180                 185                 190         
Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu 
        195                 200                 205             
Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg 
    210                 215                 220                 
Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys 
225                 230                 235                 240 
Asp Lys Ser Asp Thr Cys Phe 
                245         

<210> 14
<211> 744
<212> DNA
<213> Homo sapiens


<220> 
<223> CD86

<400> 14
atgggccgca caagttttga ttcggacagt tggaccctga gacttcacaa tcttcagatc      60

aaggacaagg gcttgtatca atgtatcatc catcacaaaa agcccacagg aatgattcgc     120

atccaccaga tgaattctga actgtcagtg cttgctaact tcagtcaacc tgaaatagta     180

ccaatttcta atataacaga aaatgtgtac ataaatttga cctgctcatc tatacacggt     240

tacccagaac ctaagaagat gagtgttttg ctaagaacca agaattcaac tatcgagtat     300

gatggtgtta tgcagaaatc tcaagataat gtcacagaac tgtacgacgt ttccatcagc     360

ttgtctgttt cattccctga tgttacgagc aatatgacca tcttctgtat tctggaaact     420

gacaagacgc ggcttttatc ttcacctttc tctatagagc ttgaggaccc tcagcctccc     480

ccagaccaca ttccttggat tacagctgta cttccaacag ttattatatg tgtgatggtt     540

ttctgtctaa ttctatggaa atggaagaag aagaagcggc ctcgcaactc ttataaatgt     600

ggaaccaaca caatggagag ggaagagagt gaacagacca agaaaagaga aaaaatccat     660

atacctgaaa gatctgatga agcccagcgt gtttttaaaa gttcgaagac atcttcatgc     720

gacaaaagtg atacatgttt ttaa                                            744


<210> 15
<211> 309
<212> PRT
<213> Mus musculus


<220> 
<223> CD86

<400> 15
Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      
Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          
Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  
Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  
Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      
Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         
Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             
Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 
Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 
Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     
Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         
Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             
Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 
Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 
Thr Tyr Trp Lys Glu Ile Thr Ala Ser Val Thr Val Ala Leu Leu Leu 
                245                 250                 255     
Val Met Leu Leu Ile Ile Val Cys His Lys Lys Pro Asn Gln Pro Ser 
            260                 265                 270         
Arg Pro Ser Asn Thr Ala Ser Lys Leu Glu Arg Asp Ser Asn Ala Asp 
        275                 280                 285             
Arg Glu Thr Ile Asn Leu Lys Glu Leu Glu Pro Gln Ile Ala Ser Ala 
    290                 295                 300                 
Lys Pro Asn Ala Glu 
305                 

<210> 16
<211> 930
<212> DNA
<213> Mus musculus


<220> 
<223> CD86

<400> 16
atggacccca gatgcaccat gggcttggca atccttatct ttgtgacagt cttgctgatc      60

tcagatgctg tttccgtgga gacgcaagct tatttcaatg ggactgcata tctgccgtgc     120

ccatttacaa aggctcaaaa cataagcctg agtgagctgg tagtattttg gcaggaccag     180

caaaagttgg ttctgtacga gcactatttg ggcacagaga aacttgatag tgtgaatgcc     240

aagtacctgg gccgcacgag ctttgacagg aacaactgga ctctacgact tcacaatgtt     300

cagatcaagg acatgggctc gtatgattgt tttatacaaa aaaagccacc cacaggatca     360

attatcctcc aacagacatt aacagaactg tcagtgatcg ccaacttcag tgaacctgaa     420

ataaaactgg ctcagaatgt aacaggaaat tctggcataa atttgacctg cacgtctaag     480

caaggtcacc cgaaacctaa gaagatgtat tttctgataa ctaattcaac taatgagtat     540

ggtgataaca tgcagatatc acaagataat gtcacagaac tgttcagtat ctccaacagc     600

ctctctcttt cattcccgga tggtgtgtgg catatgaccg ttgtgtgtgt tctggaaacg     660

gagtcaatga agatttcctc caaacctctc aatttcactc aagagtttcc atctcctcaa     720

acgtattgga aggagattac agcttcagtt actgtggccc tcctccttgt gatgctgctc     780

atcattgtat gtcacaagaa gccgaatcag cctagcaggc ccagcaacac agcctctaag     840

ttagagcggg atagtaacgc tgacagagag actatcaacc tgaaggaact tgaaccccaa     900

attgcttcag caaaaccaaa tgcagagtga                                      930


<210> 17
<211> 146
<212> PRT
<213> Homo sapiens


<220> 
<223> CD83

<400> 17
Met Glu Thr Pro Gln Glu Asp His Leu Arg Gly Gln His Tyr His Gln 
1               5                   10                  15      
Lys Gly Gln Asn Gly Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser 
            20                  25                  30          
Leu Lys Ile Arg Asn Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys 
        35                  40                  45              
Thr Leu Gln Asp Pro Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile 
    50                  55                  60                  
Leu Arg Val Thr Gly Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys 
65                  70                  75                  80  
Lys Tyr Arg Ala Glu Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr 
                85                  90                  95      
Leu Thr Leu Ile Ile Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile 
            100                 105                 110         
Phe Pro Asp Phe Ser Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val 
        115                 120                 125             
Thr Ser Pro Asn Lys His Leu Gly Leu Val Thr Pro His Lys Thr Glu 
    130                 135                 140                 
Leu Val 
145     

<210> 18
<211> 441
<212> DNA
<213> Homo sapiens


<220> 
<223> CD83

<400> 18
atggagacac cccaggaaga ccacctcagg ggacagcact atcatcagaa ggggcaaaat      60

ggttctttcg acgcccccaa tgaaaggccc tattccctga agatccgaaa cactaccagc     120

tgcaactcgg ggacatacag gtgcactctg caggacccgg atgggcagag aaacctaagt     180

ggcaaggtga tcttgagagt gacaggatgc cctgcacagc gtaaagaaga gacttttaag     240

aaatacagag cggagattgt cctgctgctg gctctggtta ttttctactt aacactcatc     300

attttcactt gtaagtttgc acggctacag agtatcttcc cagatttttc taaagctggc     360

atggaacgag cttttctccc agttacctcc ccaaataagc atttagggct agtgactcct     420

cacaagacag aactggtatg a                                               441


<210> 19
<211> 196
<212> PRT
<213> Mus musculus


<220> 
<223> CD83

<400> 19
Met Ser Gln Gly Leu Gln Leu Leu Phe Leu Gly Cys Ala Cys Ser Leu 
1               5                   10                  15      
Ala Pro Ala Met Ala Met Arg Glu Val Thr Val Ala Cys Ser Glu Thr 
            20                  25                  30          
Ala Asp Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Leu Ser Tyr Ala 
        35                  40                  45              
Val Ser Trp Ala Lys Val Ser Glu Ser Gly Thr Glu Ser Val Glu Leu 
    50                  55                  60                  
Pro Glu Ser Lys Gln Asn Ser Ser Phe Glu Ala Pro Arg Arg Arg Ala 
65                  70                  75                  80  
Tyr Ser Leu Thr Ile Gln Asn Thr Thr Ile Cys Ser Ser Gly Thr Tyr 
                85                  90                  95      
Arg Cys Ala Leu Gln Glu Leu Gly Gly Gln Arg Asn Leu Ser Gly Thr 
            100                 105                 110         
Val Val Leu Lys Val Thr Gly Cys Pro Lys Glu Ala Thr Glu Ser Thr 
        115                 120                 125             
Phe Arg Lys Tyr Arg Ala Glu Ala Val Leu Leu Phe Ser Leu Val Val 
    130                 135                 140                 
Phe Tyr Leu Thr Leu Ile Ile Phe Thr Cys Lys Phe Ala Arg Leu Gln 
145                 150                 155                 160 
Ser Ile Phe Pro Asp Ile Ser Lys Pro Gly Thr Glu Gln Ala Phe Leu 
                165                 170                 175     
Pro Val Thr Ser Pro Ser Lys His Leu Gly Pro Val Thr Leu Pro Lys 
            180                 185                 190         
Thr Glu Thr Val 
        195     

<210> 20
<211> 591
<212> DNA
<213> Mus musculus


<220> 
<223> CD83

<400> 20
atgtcgcaag gcctccagct cctgtttcta ggctgcgcct gcagcctggc acccgcgatg      60

gcgatgcggg aggtgacggt ggcttgctcc gagaccgccg acttgccttg cacagcgccc     120

tgggacccgc agctctccta tgcagtgtcc tgggccaagg tctccgagag tggcactgag     180

agtgtggagc tcccggagag caagcaaaac agctccttcg aggcccccag gagaagggcc     240

tattccctga cgatccaaaa cactaccatc tgcagctcgg gcacctacag gtgtgccctg     300

caggagctcg gagggcagcg caacttgagc ggcaccgtgg ttctgaaggt gacaggatgc     360

cccaaggaag ctacagagtc aactttcagg aagtacaggg cagaagctgt gttgctcttc     420

tctctggttg ttttctacct gacactcatc attttcacct gcaaatttgc acgactacaa     480

agcattttcc cagatatttc taaacctggt acggaacaag cttttcttcc agtcacctcc     540

ccaagcaaac atttggggcc agtgaccctt cctaagacag aaacggtatg a              591


<210> 21
<211> 208
<212> PRT
<213> Homo sapiens


<220> 
<223> CD70

<400> 21
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 
Leu Ser Phe His Gln Gly Leu Phe Gly Phe Trp Asn Trp Gly Leu Lys 
145                 150                 155                 160 
Val Lys Cys Phe Leu Arg His Leu Ile Trp Thr Ala His Cys Phe Ile 
                165                 170                 175     
Pro Leu Thr Gln Leu Val Phe Met Gln Ala Leu Gln Ser Trp Arg Asn 
            180                 185                 190         
His His Cys Ser His Phe Thr Asp Glu Glu Asn Arg Gly Val Asn Arg 
        195                 200                 205             



<210> 22
<211> 627
<212> DNA
<213> Homo sapiens


<220> 
<223> CD70

<400> 22
atgccggagg agggttcggg ctgctcggtg cggcgcaggc cctatgggtg cgtcctgcgg      60

gctgctttgg tcccattggt cgcgggcttg gtgatctgcc tcgtggtgtg catccagcgc     120

ttcgcacagg ctcagcagca gctgccgctc gagtcacttg ggtgggacgt agctgagctg     180

cagctgaatc acacaggacc tcagcaggac cccaggctat actggcaggg gggcccagca     240

ctgggccgct ccttcctgca tggaccagag ctggacaagg ggcagctacg tatccatcgt     300

gatggcatct acatggtaca catccaggtg acgctggcca tctgctcctc cacgacggcc     360

tccaggcacc accccaccac cctggccgtg ggaatctgct ctcccgcctc ccgtagcatc     420

agcctgctgc gtctcagctt ccaccaaggg ctttttggat tttggaactg gggactcaaa     480

gtcaagtgct tcttacggca tttaatatgg actgcacact gttttatccc attaactcag     540

ctcgtgttca tgcaagccct acaaagctgg aggaatcatc attgttccca tttcacagat     600

gaggaaaaca gaggcgtaaa ccgttga                                         627


<210> 23
<211> 195
<212> PRT
<213> Mus musculus


<220> 
<223> CD70

<400> 23
Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      
Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          
Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              
Gln Arg Leu Leu Glu His Pro Glu Pro His Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  
Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly 
65                  70                  75                  80  
Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly 
                85                  90                  95      
His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val 
            100                 105                 110         
Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala 
        115                 120                 125             
Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu 
    130                 135                 140                 
Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu 
145                 150                 155                 160 
Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro 
                165                 170                 175     
Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         
Ile Cys Pro 
        195 

<210> 24
<211> 588
<212> DNA
<213> Mus musculus


<220> 
<223> CD70

<400> 24
atgccggagg aaggtcgccc ttgcccctgg gttcgctgga gcgggaccgc gttccagcgc      60

caatggccat ggctgctgct ggtggtgttt attactgtgt tttgctgttg gtttcattgt     120

agcggactac tcagtaagca gcaacagagg ctgctggagc accctgagcc gcacacagct     180

gagttacagc tgaatctcac agttcctcgg aaggacccca cactgcgctg gggagcaggc     240

ccagccttgg gaaggtcctt cacacacgga ccagagctgg aggagggcca tctgcgtatc     300

catcaagatg gcctctacag gctgcatatc caggtgacac tggccaactg ctcttcccca     360

ggcagcaccc tgcagcacag ggccaccctg gctgtgggca tctgctcccc cgctgcgcac     420

ggcatcagct tgctgcgtgg gcgctttgga caggactgta cagtggcatt acagcgcctg     480

acatacctgg tccacggaga tgtcctctgt accaacctca ccctgcctct gctgccgtcc     540

cgcaacgctg atgagacctt ctttggagtt cagtggatat gcccttga                  588


<210> 25
<211> 261
<212> PRT
<213> Homo sapiens


<220> 
<223> IL7/CD127

<400> 25
Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      
Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          
Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              
Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  
Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      
Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         
Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             
Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 
Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 
Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     
Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         
Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 
Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 
Tyr Gly Pro Val Ser Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val 
                245                 250                 255     
Arg Asn Gln Glu Lys 
            260     

<210> 26
<211> 786
<212> DNA
<213> Homo sapiens


<220> 
<223> IL7/CD127

<400> 26
atgacaattc taggtacaac ttttggcatg gttttttctt tacttcaagt cgtttctgga      60

gaaagtggct atgctcaaaa tggagacttg gaagatgcag aactggatga ctactcattc     120

tcatgctata gccagttgga agtgaatgga tcgcagcact cactgacctg tgcttttgag     180

gacccagatg tcaacatcac caatctggaa tttgaaatat gtggggccct cgtggaggta     240

aagtgcctga atttcaggaa actacaagag atatatttca tcgagacaaa gaaattctta     300

ctgattggaa agagcaatat atgtgtgaag gttggagaaa agagtctaac ctgcaaaaaa     360

atagacctaa ccactatagt taaacctgag gctccttttg acctgagtgt cgtctatcgg     420

gaaggagcca atgactttgt ggtgacattt aatacatcac acttgcaaaa gaagtatgta     480

aaagttttaa tgcacgatgt agcttaccgc caggaaaagg atgaaaacaa atggacgcat     540

gtgaatttat ccagcacaaa gctgacactc ctgcagagaa agctccaacc ggcagcaatg     600

tatgagatta aagttcgatc catccctgat cactatttta aaggcttctg gagtgaatgg     660

agtccaagtt attacttcag aactccagag atcaataata gctcaggatt aagcctatcg     720

tatggcccag tctccccgat cataagaaga ctctggaaca tctttgtaag aaaccaagaa     780

aagtga                                                                786


<210> 27
<211> 286
<212> PRT
<213> Mus musculus


<220> 
<223> IL7/CD127

<400> 27
Met Met Ala Leu Gly Arg Ala Phe Ala Ile Val Phe Cys Leu Ile Gln 
1               5                   10                  15      
Ala Val Ser Gly Glu Ser Gly Asn Ala Gln Asp Gly Asp Leu Glu Asp 
            20                  25                  30          
Ala Asp Ala Asp Asp His Ser Phe Trp Cys His Ser Gln Leu Glu Val 
        35                  40                  45              
Asp Gly Ser Gln His Leu Leu Thr Cys Ala Phe Asn Asp Ser Asp Ile 
    50                  55                  60                  
Asn Thr Ala Asn Leu Glu Phe Gln Ile Cys Gly Ala Leu Leu Arg Val 
65                  70                  75                  80  
Lys Cys Leu Thr Leu Asn Lys Leu Gln Asp Ile Tyr Phe Ile Lys Thr 
                85                  90                  95      
Ser Glu Phe Leu Leu Ile Gly Ser Ser Asn Ile Cys Val Lys Leu Gly 
            100                 105                 110         
Gln Lys Asn Leu Thr Cys Lys Asn Met Ala Ile Asn Thr Ile Val Lys 
        115                 120                 125             
Ala Glu Ala Pro Ser Asp Leu Lys Val Val Tyr Arg Lys Glu Ala Asn 
    130                 135                 140                 
Asp Phe Leu Val Thr Phe Asn Ala Pro His Leu Lys Lys Lys Tyr Leu 
145                 150                 155                 160 
Lys Lys Val Lys His Asp Val Ala Tyr Arg Pro Ala Arg Gly Glu Ser 
                165                 170                 175     
Asn Trp Thr His Val Ser Leu Phe His Thr Arg Thr Thr Ile Pro Gln 
            180                 185                 190         
Arg Lys Leu Arg Pro Lys Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             
Pro His Asn Asp Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser 
    210                 215                 220                 
Ser Thr Phe Glu Thr Pro Glu Pro Lys Asn Gln Gly Gly Trp Asp Pro 
225                 230                 235                 240 
Val Leu Pro Ser Val Thr Ile Leu Ser Leu Phe Ser Val Phe Leu Leu 
                245                 250                 255     
Val Ile Leu Ala His Val Leu Trp Lys Lys Arg Ile Lys Pro Val Val 
            260                 265                 270         
Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu Gln Leu 
        275                 280                 285     

<210> 28
<211> 861
<212> DNA
<213> Mus musculus


<220> 
<223> IL7/CD127

<400> 28
atgatggctc tgggtagagc tttcgctata gttttctgct taattcaagc tgtttctgga      60

gaaagtggaa atgcccagga tggagaccta gaagatgcag acgcggacga tcactccttc     120

tggtgccaca gccagttgga agtggatgga agtcaacatt tattgacttg tgcttttaat     180

gactcagaca tcaacacagc taatctggaa tttcaaatat gtggggctct tttacgagtg     240

aaatgcctaa ctcttaacaa gctgcaagat atatatttta taaagacatc agaattctta     300

ctgattggta gcagcaatat atgtgtgaag cttggacaaa agaatttaac ttgcaaaaat     360

atggctataa acacaatagt taaagccgag gctccctctg acctgaaagt cgtttatcgc     420

aaagaagcaa atgatttttt ggtgacattt aatgcacctc acttgaaaaa gaaatattta     480

aaaaaagtaa agcatgatgt ggcctaccgc ccagcaaggg gtgaaagcaa ctggacgcat     540

gtatctttat tccacacaag aacaacaatc ccacagagaa aactacgacc aaaagcaatg     600

tatgaaatca aagtccgatc cattccccat aacgattact tcaaaggctt ctggagcgag     660

tggagtccaa gttctacctt cgaaactcca gaacccaaga atcaaggagg atgggatcct     720

gtcttgccaa gtgtcaccat tctgagtttg ttctctgtgt ttttgttggt catcttagcc     780

catgtgctat ggaaaaaaag gattaaacct gtcgtatggc ctagtctccc cgatcataag     840

aaaactctgg aacaactata g                                               861


<210> 29
<211> 164
<212> PRT
<213> Homo sapiens


<220> 
<223> CD30L

<400> 29
Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      
Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          
Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              
Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  
Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  
Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      
Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         
Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             
Gly Asn Leu Val Ile Gln Phe Pro Asp Tyr Cys Gly Met Ile Leu His 
    130                 135                 140                 
His Ser His Ser Thr Leu Asp Ser Gly Lys Gly His Cys Cys Leu Glu 
145                 150                 155                 160 
Thr Leu Gln Pro 
                

<210> 30
<211> 495
<212> DNA
<213> Homo sapiens


<220> 
<223> CD30L

<400> 30
atggacccag ggctgcagca agcactcaac ggaatggccc ctcctggaga cacagccatg      60

catgtgccgg cgggctccgt ggccagccac ctggggacca cgagccgcag ctatttctat     120

ttgaccacag ccactctggc tctgtgcctt gtcttcacgg tggccactat tatggtgttg     180

gtcgttcaga ggacggactc cattcccaac tcacctgaca acgtccccct caaaggagga     240

aattgctcag aagacctctt atgtatcctg aaaagggctc cattcaagaa gtcatgggcc     300

tacctccaag tggcaaagca tctaaacaaa accaagttgt cttggaacaa agatggcatt     360

ctccatggag tcagatatca ggatgggaat ctggtgatcc aattccctga ttactgtggc     420

atgatcctcc accattcaca ctctaccctg gactctggga agggacactg ctgccttgaa     480

actctacaac cctga                                                      495


<210> 31
<211> 220
<212> PRT
<213> Mus musculus


<220> 
<223> CD30L

<400> 31
Met Glu Pro Gly Leu Gln Gln Ala Gly Ser Cys Gly Ala Pro Ser Pro 
1               5                   10                  15      
Asp Pro Ala Met Gln Val Gln Pro Gly Ser Val Ala Ser Pro Trp Arg 
            20                  25                  30          
Ser Thr Arg Pro Trp Arg Ser Thr Ser Arg Ser Tyr Phe Tyr Leu Ser 
        35                  40                  45              
Thr Thr Ala Leu Val Cys Leu Val Val Ala Val Ala Ile Ile Leu Val 
    50                  55                  60                  
Leu Val Val Gln Lys Lys Asp Ser Thr Pro Asn Thr Thr Glu Lys Ala 
65                  70                  75                  80  
Pro Leu Lys Gly Gly Asn Cys Ser Glu Asp Leu Phe Cys Thr Leu Lys 
                85                  90                  95      
Ser Thr Pro Ser Lys Lys Ser Trp Ala Tyr Leu Gln Val Ser Lys His 
            100                 105                 110         
Leu Asn Asn Thr Lys Leu Ser Trp Asn Glu Asp Gly Thr Ile His Gly 
        115                 120                 125             
Leu Ile Tyr Gln Asp Gly Asn Leu Ile Val Gln Phe Pro Gly Leu Tyr 
    130                 135                 140                 
Phe Ile Val Cys Gln Leu Gln Phe Leu Val Gln Cys Ser Asn His Ser 
145                 150                 155                 160 
Val Asp Leu Thr Leu Gln Leu Leu Ile Asn Ser Lys Ile Lys Lys Gln 
                165                 170                 175     
Thr Leu Val Thr Val Cys Glu Ser Gly Val Gln Ser Lys Asn Ile Tyr 
            180                 185                 190         
Gln Asn Leu Ser Gln Phe Leu Leu His Tyr Leu Gln Val Asn Ser Thr 
        195                 200                 205             
Ile Ser Val Arg Val Asp Asn Phe Gln Tyr Val Asp 
    210                 215                 220 

<210> 32
<211> 720
<212> DNA
<213> Mus musculus


<220> 
<223> CD30L

<400> 32
atggagccag ggctgcaaca agcaggcagc tgtggggctc cttcccctga cccagccatg      60

caggtgcagc ccggctcggt agccagcccc tggagaagca cgaggccctg gagaagcaca     120

agtcgcagct acttctacct cagcaccacc gcactggtgt gccttgttgt ggcagtggcg     180

atcattctgg tactggtagt ccagaaaaag gactccactc caaatacaac tgagaaggcc     240

ccccttaaag gaggaaattg ctcagaggat ctcttctgta ccctgaaaag tactccatcc     300

aagaagtcat gggcctacct ccaagtgtca aagcatctca acaataccaa actgtcatgg     360

aacgaagatg gcaccatcca cggactcata taccaggacg ggaacctgat agtccaattc     420

cctggcttgt acttcatcgt ttgccaactg cagttcctcg tgcagtgctc aaatcattct     480

gtggacctga cattgcagct cctcatcaat tccaagatca aaaagcagac gttggtaaca     540

gtgtgtgagt ctggagttca gagtaagaac atctaccaga atctctctca gtttttgctg     600

cattacttac aggtcaactc taccatatca gtcagggtgg ataatttcca gtatgtggat     660

acaaacactt tccctcttga taatgtgcta tccgtcttct tatatagtag ctcagactga     720


<210> 33
<211> 231
<212> PRT
<213> Homo sapiens


<220> 
<223> LIGHT

<400> 33
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      
Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          
Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              
Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  
Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  
Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      
Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         
Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             
Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 
Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 
Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     
Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         
Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             
Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 
Val Lys Arg Arg Lys Pro Arg 
225                 230     

<210> 34
<211> 694
<212> DNA
<213> Homo sapiens


<220> 
<223> LIGHT

<400> 34
atggagcctc ctggagactg ggggcctcct ccctggagat ccacccccaa aaccgacgtc      60

ttgaggctgg tgctgtatct caccttcctg ggagccccct gctacgcccc agctctgccg     120

tcctgcaagg aggacgagta cccagtgggc tccgagtgct gccccaagtg cagtccaggt     180

tatcgtgtga aggaggcctg cggggagctg acgggcacag tgtgtgaacc ctgccctcca     240

ggcacctaca ttgcccacct caatggccta agcaagtgtc tgcagtgcca aatgtgtgac     300

ccagccatgg gcctgcgcgc gagccggaac tgctccagga cagagaacgc cgtgtgtggc     360

tgcagcccag gccacttctg catcgtccag gacggggacc actgcgccgc gtgccgcgct     420

tacgccacct ccagcccggg ccagagggtg cagaagggag gcaccgagag tcaggacacc     480

ctgtgtcaga actgcccccc ggggaccttc tctcccaatg ggaccctgga ggaatgtcag     540

caccagacca agtgcagctg gctggtgacg aaggccggag ctgggaccag cagctcccac     600

tgggtatggt ggtttctctc agggagcctc gtcatcgtca ttgtttgctc cacagttggc     660

ctaatcatat gtgtgaaaag aagaaagcca aggg                                 694


<210> 35
<211> 239
<212> PRT
<213> Mus musculus


<220> 
<223> LIGHT

<400> 35
Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      
Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          
Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              
Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  
Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  
Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      
Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         
Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             
Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 
Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 
Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     
Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         
Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             
Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 
Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 

<210> 36
<211> 720
<212> DNA
<213> Mus musculus


<220> 
<223> LIGHT

<400> 36
atggagagtg tggtacagcc ttcagtgttt gtggtggatg gacagacgga catcccattc      60

aggcggctgg aacagaacca ccggagacgg cgctgtggca ctgtccaggt cagcctggcc     120

ctggtgctgc tgctaggtgc tgggctggcc actcagggct ggtttctcct gagactgcat     180

caacgtcttg gagacatagt agctcatctg ccagatggag gcaaaggctc ctgggagaag     240

ctgatacaag atcaacgatc tcaccaggcc aacccagcag cacatcttac aggagccaac     300

gccagcttga taggtattgg tggacctctg ttatgggaga cacgacttgg cctggccttc     360

ttgaggggct tgacgtatca tgatggggcc ctggtgacca tggagcccgg ttactactat     420

gtgtactcca aagtgcagct gagcggcgtg ggctgccccc aggggctggc caatggcctc     480

cccatcaccc atggactata caagcgcaca tcccgctacc cgaaggagtt agaactgctg     540

gtcagtcggc ggtcaccctg tggccgggcc aacagctccc gagtctggtg ggacagcagc     600

ttcctgggcg gcgtggtaca tctggaggct ggggaagagg tggtggtccg cgtgcctgga     660

aaccgcctgg tcagaccacg tgacggcacc aggtcctatt tcggagcttt catggtctga     720


<210> 37
<211> 289
<212> PRT
<213> Homo sapiens


<220> 
<223> BTLA

<400> 37
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      
Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          
Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              
Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  
Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  
Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      
Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         
Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             
Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 
Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 
Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     
Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         
Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             
Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 
Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 
Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     
Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         
Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             
Ser 
    

<210> 38
<211> 870
<212> DNA
<213> Homo sapiens


<220> 
<223> BTLA

<400> 38
atgaagacat tgcctgccat gcttggaact gggaaattat tttgggtctt cttcttaatc      60

ccatatctgg acatctggaa catccatggg aaagaatcat gtgatgtaca gctttatata     120

aagagacaat ctgaacactc catcttagca ggagatccct ttgaactaga atgccctgtg     180

aaatactgtg ctaacaggcc tcatgtgact tggtgcaagc tcaatggaac aacatgtgta     240

aaacttgaag atagacaaac aagttggaag gaagagaaga acatttcatt tttcattcta     300

cattttgaac cagtgcttcc taatgacaat gggtcatacc gctgttctgc aaattttcag     360

tctaatctca ttgaaagcca ctcaacaact ctttatgtga cagatgtaaa aagtgcctca     420

gaacgaccct ccaaggacga aatggcaagc agaccctggc tcctgtatcg tttacttcct     480

ttggggggat tgcctctact catcactacc tgtttctgcc tgttctgctg cctgagaagg     540

caccaaggaa agcaaaatga actctctgac acagcaggaa gggaaattaa cctggttgat     600

gctcacctta agagtgagca aacagaagca agcaccaggc aaaattccca agtactgcta     660

tcagaaactg gaatttatga taatgaccct gacctttgtt tcaggatgca ggaagggtct     720

gaagtttatt ctaatccatg cctggaagaa aacaaaccag gcattgttta tgcttccctg     780

aaccattctg tcattggacc gaactcaaga ctggcaagaa atgtaaaaga agcaccaaca     840

gaatatgcat ccatatgtgt gaggagttaa                                      870


<210> 39
<211> 305
<212> PRT
<213> Mus musculus


<220> 
<223> BTLA

<400> 39
Met Lys Thr Val Pro Ala Met Leu Gly Thr Pro Arg Leu Phe Arg Glu 
1               5                   10                  15      
Phe Phe Ile Leu His Leu Gly Leu Trp Ser Ile Leu Cys Glu Lys Ala 
            20                  25                  30          
Thr Lys Arg Asn Asp Glu Glu Cys Pro Val Gln Leu Thr Ile Thr Arg 
        35                  40                  45              
Asn Ser Lys Gln Ser Ala Arg Thr Gly Glu Leu Phe Lys Ile Gln Cys 
    50                  55                  60                  
Pro Val Lys Tyr Cys Val His Arg Pro Asn Val Thr Trp Cys Lys His 
65                  70                  75                  80  
Asn Gly Thr Ile Cys Val Pro Leu Glu Val Ser Pro Gln Leu Tyr Thr 
                85                  90                  95      
Ser Trp Glu Glu Asn Gln Ser Val Pro Val Phe Val Leu His Phe Lys 
            100                 105                 110         
Pro Ile His Leu Ser Asp Asn Gly Ser Tyr Ser Cys Ser Thr Asn Phe 
        115                 120                 125             
Asn Ser Gln Val Ile Asn Ser His Ser Val Thr Ile His Val Thr Glu 
    130                 135                 140                 
Arg Thr Gln Asn Ser Ser Glu His Pro Leu Ile Ile Ser Asp Ile Pro 
145                 150                 155                 160 
Asp Ala Thr Asn Ala Ser Gly Pro Ser Thr Met Glu Glu Arg Pro Gly 
                165                 170                 175     
Arg Thr Trp Leu Leu Tyr Thr Leu Leu Pro Leu Gly Ala Leu Leu Leu 
            180                 185                 190         
Leu Leu Ala Cys Val Cys Leu Leu Cys Phe Leu Lys Arg Ile Gln Gly 
        195                 200                 205             
Lys Glu Lys Lys Pro Ser Asp Leu Ala Gly Arg Asp Thr Asn Leu Val 
    210                 215                 220                 
Asp Ile Pro Ala Ser Ser Arg Thr Asn His Gln Ala Leu Pro Ser Gly 
225                 230                 235                 240 
Thr Gly Ile Tyr Asp Asn Asp Pro Trp Ser Ser Met Gln Asp Glu Ser 
                245                 250                 255     
Glu Leu Thr Ile Ser Leu Gln Ser Glu Arg Asn Asn Gln Gly Ile Val 
            260                 265                 270         
Tyr Ala Ser Leu Asn His Cys Val Ile Gly Arg Asn Pro Arg Gln Glu 
        275                 280                 285             
Asn Asn Met Gln Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
    290                 295                 300                 
Ser 
305 

<210> 40
<211> 918
<212> DNA
<213> Mus musculus


<220> 
<223> BTLA

<400> 40
atgaagacag tgcctgccat gcttgggact cctcggttat ttagggaatt cttcatcctc      60

catctgggcc tctggagcat cctttgtgag aaagctacta agaggaatga tgaagagtgt     120

ccagtgcaac ttactattac gaggaattcc aaacagtctg ccaggacagg agagttattt     180

aaaattcaat gtcctgtgaa atactgtgtt catagaccta atgtgacttg gtgtaagcac     240

aatggaacaa tctgtgtacc ccttgaggtt agccctcagc tatacactag ttgggaagaa     300

aatcaatcag ttccggtttt tgttctccac tttaaaccaa tacatctcag tgataatggg     360

tcgtatagct gttctacaaa cttcaattct caagttatta atagccattc agtaaccatc     420

catgtgacag aaaggactca aaactcttca gaacacccac taataatatc tgacatccca     480

gatgccacca atgcctcagg accatccacc atggaagaga ggccaggcag gacttggctg     540

ctttacacct tgcttccttt gggggcattg cttctgctcc ttgcctgtgt ctgcctgctc     600

tgctttctga aaaggatcca agggaaagaa aagaagcctt ctgacttggc aggaagggac     660

actaacctgg ttgatattcc agccagttcc aggacaaatc accaagcact gccatcagga     720

actggaattt atgataatga tccctggtct agcatgcagg atgaatctga attgacaatt     780

agcttgcaat cagagagaaa caaccagggc attgtttatg cttctttgaa ccattgtgtt     840

attggaagga atccaagaca ggaaaacaac atgcaggagg cacccacaga atatgcatcc     900

atttgtgtga gaagttaa                                                   918


<210> 41
<211> 309
<212> PRT
<213> Homo sapiens


<220> 
<223> ICOS-L

<400> 41
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      
Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          
Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              
Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  
Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  
Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      
Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         
Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             
Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 
Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 
Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     
Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         
Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             
Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 
Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 
Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     
Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         
Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             
Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Glu Ser Trp Asn Leu 
    290                 295                 300                 
Leu Leu Leu Leu Ser 
305                 

<210> 42
<211> 930
<212> DNA
<213> Homo sapiens


<220> 
<223> ICOS-L

<400> 42
atgcggctgg gcagtcctgg actgctcttc ctgctcttca gcagccttcg agctgatact      60

caggagaagg aagtcagagc gatggtaggc agcgacgtgg agctcagctg cgcttgccct     120

gaaggaagcc gttttgattt aaatgatgtt tacgtatatt ggcaaaccag tgagtcgaaa     180

accgtggtga cctaccacat cccacagaac agctccttgg aaaacgtgga cagccgctac     240

cggaaccgag ccctgatgtc accggccggc atgctgcggg gcgacttctc cctgcgcttg     300

ttcaacgtca ccccccagga cgagcagaag tttcactgcc tggtgttgag ccaatccctg     360

ggattccagg aggttttgag cgttgaggtt acactgcatg tggcagcaaa cttcagcgtg     420

cccgtcgtca gcgcccccca cagcccctcc caggatgagc tcaccttcac gtgtacatcc     480

ataaacggct accccaggcc caacgtgtac tggatcaata agacggacaa cagcctgctg     540

gaccaggctc tgcagaatga caccgtcttc ttgaacatgc ggggcttgta tgacgtggtc     600

agcgtgctga ggatcgcacg gacccccagc gtgaacattg gctgctgcat agagaacgtg     660

cttctgcagc agaacctgac tgtcggcagc cagacaggaa atgacatcgg agagagagac     720

aagatcacag agaatccagt cagtaccggc gagaaaaacg cggccacgtg gagcatcctg     780

gctgtcctgt gcctgcttgt ggtcgtggcg gtggccatag gctgggtgtg cagggaccga     840

tgcctccaac acagctatgc aggtgcctgg gctgtgagtc cggagacaga gctcactgaa     900

tcctggaacc tgctccttct gctctcgtga                                      930


<210> 43
<211> 343
<212> PRT
<213> Mus musculus


<220> 
<223> ICOS-L

<400> 43
Cys Pro Cys Phe Val Ser Leu Gly Thr Arg Gln Pro Val Trp Lys Lys 
1               5                   10                  15      
Leu His Val Ser Ser Gly Phe Phe Ser Gly Leu Gly Leu Phe Leu Leu 
            20                  25                  30          
Leu Leu Ser Ser Leu Cys Ala Ala Ser Ala Glu Thr Glu Val Gly Ala 
        35                  40                  45              
Met Val Gly Ser Asn Val Val Leu Ser Cys Ile Asp Pro His Arg Arg 
    50                  55                  60                  
His Phe Asn Leu Ser Gly Leu Tyr Val Tyr Trp Gln Ile Glu Asn Pro 
65                  70                  75                  80  
Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr Lys Ser Pro Gly Ile Asn 
                85                  90                  95      
Val Asp Ser Ser Tyr Lys Asn Arg Gly His Leu Ser Leu Asp Ser Met 
            100                 105                 110         
Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys Asn Val Thr Pro Gln Asp 
        115                 120                 125             
Thr Gln Glu Phe Thr Cys Arg Val Phe Met Asn Thr Ala Thr Glu Leu 
    130                 135                 140                 
Val Lys Ile Leu Glu Glu Val Val Arg Leu Arg Val Ala Ala Asn Phe 
145                 150                 155                 160 
Ser Thr Pro Val Ile Ser Thr Ser Asp Ser Ser Asn Pro Gly Gln Glu 
                165                 170                 175     
Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly Tyr Pro Glu Pro Asn Leu 
            180                 185                 190         
Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu Ile Asp Thr Ala Leu Gln 
        195                 200                 205             
Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly Leu Tyr Asp Val Ile Ser 
    210                 215                 220                 
Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly Asp Val Leu Cys Cys Val 
225                 230                 235                 240 
Glu Asn Val Ala Leu His Gln Asn Ile Thr Ser Ile Ser Gln Ala Glu 
                245                 250                 255     
Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro Gln Glu Thr His Asn Asn 
            260                 265                 270         
Glu Leu Lys Val Leu Val Pro Val Leu Ala Val Leu Ala Ala Ala Ala 
        275                 280                 285             
Phe Val Ser Phe Ile Ile Tyr Arg Arg Thr Arg Pro His Arg Ser Tyr 
    290                 295                 300                 
Thr Gly Pro Lys Thr Val Gln Leu Glu Leu Thr Asp Thr Trp Ala Pro 
305                 310                 315                 320 
Val Pro Tyr Gln Asp Tyr Leu Ile Pro Arg Tyr Leu Met Ser Pro Cys 
                325                 330                 335     
Leu Lys Thr Arg Gly Leu Pro 
            340             

<210> 44
<211> 1033
<212> DNA
<213> Mus musculus


<220> 
<223> ICOS-L

<400> 44
gtgtccctgt tttgtgtcct tgggaaccag gcagcctgtt tggaagaagc tccatgtttc      60

tagcgggttc ttttctggtc ttggtctgtt cttgctgctg ttgagcagcc tctgtgctgc     120

ctctgcagag actgaagtcg gtgcaatggt gggcagcaat gtggtgctca gctgcattga     180

cccccacaga cgccatttca acttgagtgg tctgtatgtc tattggcaaa tcgaaaaccc     240

agaagtttcg gtgacttact acctgcctta caagtctcca gggatcaatg tggacagttc     300

ctacaagaac aggggccatc tgtccctgga ctccatgaag cagggtaact tctctctgta     360

cctgaagaat gtcacccctc aggataccca ggagttcaca tgccgggtat ttatgaatac     420

agccacagag ttagtcaaga tcttggaaga ggtggtcagg ctgcgtgtgg cagcaaactt     480

cagtacacct gtcatcagca cctctgatag ctccaacccg ggccaggaac gtacctacac     540

ctgcatgtcc aagaatggct acccagagcc caacctgtat tggatcaaca caacggacaa     600

tagcctaata gacacggctc tgcagaataa cactgtctac ttgaacaagt tgggcctgta     660

tgatgtaatc agcacattaa ggctcccttg gacatctcgt ggggatgttc tgtgctgcgt     720

agagaatgtg gctctccacc agaacatcac tagcattagc caggcagaaa gtttcactgg     780

aaataacaca aagaacccac aggaaaccca caataatgag ttaaaagtcc ttgtccccgt     840

ccttgctgta ctggcggcag cggcattcgt ttccttcatc atatacagac gcacgcgtcc     900

ccaccgaagc tatacaggac ccaagactgt acagcttgaa cttacagaca cttgggctcc     960

cgtcccctac caggactatt tgattccaag atatttgatg tctccatgcc tcaaaacacg    1020

tggtttacca taa                                                       1033


<210> 45
<211> 335
<212> PRT
<213> Homo sapiens


<220> 
<223> CD150

<400> 45
Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      
Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          
Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              
Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  
Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  
Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      
Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         
Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             
Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 
Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 
Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     
Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         
Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             
Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 
Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 
Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     
Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         
Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             
Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 
Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 
Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 

<210> 46
<211> 1008
<212> DNA
<213> Homo sapiens


<220> 
<223> CD150

<400> 46
atggatccca aggggctcct ctccttgacc ttcgtgctgt ttctctccct ggcttttggg      60

gcaagctacg gaacaggtgg gcgcatgatg aactgcccaa agattctccg gcagttggga     120

agcaaagtgc tgctgcccct gacatatgaa aggataaata agagcatgaa caaaagcatc     180

cacattgtcg tcacaatggc aaaatcactg gagaacagtg tcgagaacaa aatagtgtct     240

cttgatccat ccgaagcagg ccctccacgt tatctaggag atcgctacaa gttttatctg     300

gagaatctca ccctggggat acgggaaagc aggaaggagg atgagggatg gtaccttatg     360

accctggaga aaaatgtttc agttcagcgc ttttgcctgc agttgaggct ttatgagcag     420

gtctccactc cagaaattaa agttttaaac aagacccagg agaacgggac ctgcaccttg     480

atactgggct gcacagtgga gaagggggac catgtggctt acagctggag tgaaaaggcg     540

ggcacccacc cactgaaccc agccaacagc tcccacctcc tgtccctcac cctcggcccc     600

cagcatgctg acaatatcta catctgcacc gtgagcaacc ctatcagcaa caattcccag     660

accttcagcc cgtggcccgg atgcaggaca gacccctcag aaacaaaacc atgggcagtg     720

tatgctgggc tgttaggggg tgtcatcatg attctcatca tggtggtaat actacagttg     780

agaagaagag gtaaaacgaa ccattaccag acaacagtgg aaaaaaaaag ccttacgatc     840

tatgcccaag tccagaaacc aggtcctctt cagaagaaac ttgactcctt cccagctcag     900

gacccttgca ccaccatata tgttgctgcc acagagcctg tcccagagtc tgtccaggaa     960

acaaattcca tcacagtcta tgctagtgtg acacttccag agagctga                 1008


<210> 47
<211> 343
<212> PRT
<213> Mus musculus


<220> 
<223> CD150

<400> 47
Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      
Leu Ala Phe Glu Leu Ser Tyr Gly Thr Gly Gly Gly Val Met Asp Cys 
            20                  25                  30          
Pro Val Ile Leu Gln Lys Leu Gly Gln Asp Thr Trp Leu Pro Leu Thr 
        35                  40                  45              
Asn Glu His Gln Ile Asn Lys Ser Val Asn Lys Ser Val Arg Ile Leu 
    50                  55                  60                  
Val Thr Met Ala Thr Ser Pro Gly Ser Lys Ser Asn Lys Lys Ile Val 
65                  70                  75                  80  
Ser Phe Asp Leu Ser Lys Gly Ser Tyr Pro Asp His Leu Glu Asp Gly 
                85                  90                  95      
Tyr His Phe Gln Ser Lys Asn Leu Ser Leu Lys Ile Leu Gly Asn Arg 
            100                 105                 110         
Arg Glu Ser Glu Gly Trp Tyr Leu Val Ser Val Glu Glu Asn Val Ser 
        115                 120                 125             
Val Gln Gln Phe Cys Lys Gln Leu Lys Leu Tyr Glu Gln Val Ser Pro 
    130                 135                 140                 
Pro Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Glu Asn Gly Thr 
145                 150                 155                 160 
Cys Ser Leu Leu Leu Ala Cys Thr Val Lys Lys Gly Asp His Val Thr 
                165                 170                 175     
Tyr Ser Trp Ser Asp Glu Ala Gly Thr His Leu Leu Ser Arg Ala Asn 
            180                 185                 190         
Arg Ser His Leu Leu His Ile Thr Leu Ser Asn Gln His Gln Asp Ser 
        195                 200                 205             
Ile Tyr Asn Cys Thr Ala Ser Asn Pro Val Ser Ser Ile Ser Arg Thr 
    210                 215                 220                 
Phe Asn Leu Ser Ser Gln Ala Cys Lys Gln Glu Ser Ser Ser Glu Ser 
225                 230                 235                 240 
Ser Pro Trp Met Gln Tyr Thr Leu Val Pro Leu Gly Val Val Ile Ile 
                245                 250                 255     
Phe Ile Leu Val Phe Thr Ala Ile Ile Met Met Lys Arg Gln Gly Lys 
            260                 265                 270         
Ser Asn His Cys Gln Pro Pro Val Glu Glu Lys Ser Leu Thr Ile Tyr 
        275                 280                 285             
Ala Gln Val Gln Lys Ser Gly Pro Gln Glu Lys Lys Leu His Asp Ala 
    290                 295                 300                 
Leu Thr Asp Gln Asp Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu 
305                 310                 315                 320 
Pro Ala Pro Glu Ser Val Gln Glu Pro Asn Pro Thr Thr Val Tyr Ala 
                325                 330                 335     
Ser Val Thr Leu Pro Glu Ser 
            340             

<210> 48
<211> 1032
<212> DNA
<213> Mus musculus


<220> 
<223> CD150

<400> 48
atggatccca aaggatccct ttcctggaga atacttctgt ttctctccct ggcttttgag      60

ttgagctacg gaacaggtgg aggtgtgatg gattgcccag tgattctcca gaagctggga     120

caggacacgt ggctgcccct gacgaatgaa catcagataa ataagagcgt gaacaaaagt     180

gtccgcatcc tcgtcaccat ggcgacgtcc ccaggaagca aatccaacaa gaaaattgtg     240

tcttttgatc tctctaaagg gagctatcca gatcacctgg aggatggcta ccactttcaa     300

tcaaaaaacc tgagcctgaa gatcctcggg aacaggcggg agagtgaagg atggtacttg     360

gtgagcgtgg aggagaacgt ttctgttcag caattctgca agcagctgaa gctttatgaa     420

caggtctccc ctccagagat taaagtgcta aacaaaaccc aggagaacga gaatgggacc     480

tgcagcttgc tgttggcctg cacagtgaag aaaggggacc atgtgactta cagctggagt     540

gatgaggcag gcacccacct gctgagccga gccaaccgct cccacctcct gcacatcact     600

cttagcaacc agcatcaaga cagcatctac aactgcaccg caagcaaccc tgtcagcagt     660

atctctagga ccttcaacct atcatcgcaa gcatgcaagc aggaatcctc ctcagaatcg     720

agtccatgga tgcaatatac tcttgtacca ctgggggtcg ttataatctt catcctggtt     780

ttcacggcaa taataatgat gaaaagacaa ggtaaatcaa atcactgcca gccaccagtg     840

gaagaaaaaa gccttactat ttatgcccaa gtacagaaat cagggcctca agagaagaaa     900

cttcatgatg ccctaacaga tcaggacccc tgcacaacca tttatgtggc tgccacagag     960

cctgccccag agtctgtcca ggaaccaaac cccaccacag tttatgccag tgtgacactg    1020

ccagagagct ga                                                        1032


<210> 49
<211> 215
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-12

<400> 49
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      
Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          
Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              
Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  
Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  
Ala Val Ser Asn Met Leu Gln Lys Asn Glu Ser Cys Leu Asn Ser Arg 
                85                  90                  95      
Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
            100                 105                 110         
Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             
Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
    130                 135                 140                 
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
145                 150                 155                 160 
Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
                165                 170                 175     
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
            180                 185                 190         
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
        195                 200                 205             
Met Ser Tyr Leu Asn Ala Ser 
    210                 215 

<210> 50
<211> 648
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-12

<400> 50
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg      60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc     120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc     180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg     240

gccgtcagca acatgctcca gaagaatgag agttgcctaa attccagaga gacctctttc     300

ataactaatg ggagttgcct ggcctccaga aagacctctt ttatgatggc cctgtgcctt     360

agtagtattt atgaagactt gaagatgtac caggtggagt tcaagaccat gaatgcaaag     420

cttctgatgg atcctaagag gcagatcttt ctagatcaaa acatgctggc agttattgat     480

gagctgatgc aggccctgaa tttcaacagt gagactgtgc cacaaaaatc ctcccttgaa     540

gaaccggatt tttataaaac taaaatcaag ctctgcatac ttcttcatgc tttcagaatt     600

cgggcagtga ctattgatag agtgatgagc tatctgaatg cttcctaa                  648


<210> 51
<211> 335
<212> PRT
<213> Mus musculus


<220> 
<223> IL-12

<400> 51
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      
Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          
Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              
Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  
Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  
Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      
Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         
Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             
Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 
Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 
Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     
Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         
Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             
Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 
Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 
Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     
Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         
Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             
Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 
Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 
Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 

<210> 52
<211> 1008
<212> DNA
<213> Mus musculus


<220> 
<223> IL-12

<400> 52
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc      60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat     120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg     180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa     240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca     300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc     360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca     420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct     480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac     540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc     600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac     660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag     720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc     780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag     840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct     900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat     960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatcctag                 1008


<210> 53
<211> 133
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-7

<400> 53
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      
Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          
Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              
Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  
Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  
Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      
Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         
Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             
Gly Thr Lys Glu His 
    130             

<210> 54
<211> 401
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-7

<400> 54
atgttccatg tttcttttag gtatatcttt ggacttcctc ccctgatcct tgttctgttg      60

ccagtagcat catctgattg tgatattgaa ggtaaagatg gcaaacaata tgagagtgtt     120

ctaatggtca gcatcgatca attattggac agcatgaaag aaattggtag caattgcctg     180

aataatgaat ttaacttttt taaaagacat atctgtgatg ctaataaggt taaaggaaga     240

aaaccagctg ccctgggtga agcccaacca acaaagagtt tggaagaaaa taaatcttta     300

aaggaacaga aaaaactgaa tgacttgtgt ttcctaaaga gactattaca agagataaaa     360

acttgttgga ataaaatttt gatgggcact aaagaacact g                         401


<210> 55
<211> 154
<212> PRT
<213> Mus musculus


<220> 
<223> IL-7

<400> 55
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      
Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          
Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              
Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  
Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  
Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      
Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         
Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             
Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 
Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 

<210> 56
<211> 465
<212> DNA
<213> Mus musculus


<220> 
<223> IL-7

<400> 56
atgttccatg tttcttttag atatatcttt ggaattcctc cactgatcct tgttctgctg      60

cctgtcacat catctgagtg ccacattaaa gacaaagaag gtaaagcata tgagagtgta     120

ctgatgatca gcatcgatga attggacaaa atgacaggaa ctgatagtaa ttgcccgaat     180

aatgaaccaa acttttttag aaaacatgta tgtgatgata caaaggaagc tgcttttcta     240

aatcgtgctg ctcgcaagtt gaagcaattt cttaaaatga atatcagtga agaattcaat     300

gtccacttac taacagtatc acaaggcaca caaacactgg tgaactgcac aagtaaggaa     360

gaaaaaaacg taaaggaaca gaaaaagaat gatgcatgtt tcctaaagag actactgaga     420

gaaataaaaa cttgttggaa taaaattttg aagggcagta tataa                     465


<210> 57
<211> 162
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-15

<400> 57
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      
Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          
Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 
Thr Ser 
        

<210> 58
<211> 489
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-15

<400> 58
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt      60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt     120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt     180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac     240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt     300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac     360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag     420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac     480

acttcttga                                                             489


<210> 59
<211> 180
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-17

<400> 59
Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      
Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          
Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              
Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  
Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  
Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      
Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         
Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             
Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 
Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 
Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     
Thr Cys Ile Phe 
            180 

<210> 60
<211> 543
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-17

<400> 60
atggactggc ctcacaacct gctgtttctt cttaccattt ccatcttcct ggggctgggc      60

cagcccagga gccccaaaag caagaggaag gggcaagggc ggcctgggcc cctggcccct     120

ggccctcacc aggtgccact ggacctggtg tcacggatga aaccgtatgc ccgcatggag     180

gagtatgaga ggaacatcga ggagatggtg gcccagctga ggaacagctc agagctggcc     240

cagagaaagt gtgaggtcaa cttgcagctg tggatgtcca acaagaggag cctgtctccc     300

tggggctaca gcatcaacca cgaccccagc cgtatccccg tggacctgcc ggaggcacgg     360

tgcctgtgtc tgggctgtgt gaaccccttc accatgcagg aggaccgcag catggtgagc     420

gtgccggtgt tcagccaggt tcctgtgcgc cgccgcctct gcccgccacc gccccgcaca     480

gggccttgcc gccagcgcgc agtcatggag accatcgctg tgggctgcac ctgcatcttc     540

tga                                                                   543


<210> 61
<211> 158
<212> PRT
<213> Mus musculus


<220> 
<223> IL-17

<400> 61
Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
1               5                   10                  15      
Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser 
            20                  25                  30          
Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
        35                  40                  45              
Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
    50                  55                  60                  
Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
65                  70                  75                  80  
Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      
Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         
Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             
Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 
Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala 
145                 150                 155             

<210> 62
<211> 477
<212> DNA
<213> Mus musculus


<220> 
<223> IL-17

<400> 62
atgagtccag ggagagcttc atctgtgtct ctgatgctgt tgctgctgct gagcctggcg      60

gctacagtga aggcagcagc gatcatccct caaagctcag cgtgtccaaa cactgaggcc     120

aaggacttcc tccagaatgt gaaggtcaac ctcaaagtct ttaactccct tggcgcaaaa     180

gtgagctcca gaaggccctc agactacctc aaccgttcca cgtcaccctg gactctccac     240

cgcaatgaag accctgatag atatccctct gtgatctggg aagctcagtg ccgccaccag     300

cgctgtgtca atgcggaggg aaagctggac caccacatga attctgttct catccagcaa     360

gagatcctgg tcctgaagag ggagcctgag agctgcccct tcactttcag ggtcgagaag     420

atgctggtgg gtgtgggctg cacctgcgtg gcctcgattg tccgccaggc agcctaa        477


<210> 63
<211> 162
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-21

<400> 63
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      
Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          
Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              
Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  
Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  
Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      
Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         
Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             
Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 
Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 
Asp Ser 
        

<210> 64
<211> 489
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-21

<400> 64
atgagatcca gtcctggcaa catggagagg attgtcatct gtctgatggt catcttcttg      60

gggacactgg tccacaaatc aagctcccaa ggtcaagatc gccacatgat tagaatgcgt     120

caacttatag atattgttga tcagctgaaa aattatgtga atgacttggt ccctgaattt     180

ctgccagctc cagaagatgt agagacaaac tgtgagtggt cagctttttc ctgctttcag     240

aaggcccaac taaagtcagc aaatacagga aacaatgaaa ggataatcaa tgtatcaatt     300

aaaaagctga agaggaaacc accttccaca aatgcaggga gaagacagaa acacagacta     360

acatgccctt catgtgattc ttatgagaaa aaaccaccca aagaattcct agaaagattc     420

aaatcacttc tccaaaagat gattcatcag catctgtcct ctagaacaca cggaagtgaa     480

gattcctga                                                             489


<210> 65
<211> 146
<212> PRT
<213> Mus musculus


<220> 
<223> IL-21

<400> 65
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      
Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          
Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              
Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  
Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  
Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      
Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         
Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             
Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 
Leu Ser 
145     

<210> 66
<211> 441
<212> DNA
<213> Mus musculus


<220> 
<223> IL-21

<400> 66
atggagagga cccttgtctg tctggtagtc atcttcttgg ggacagtggc ccataaatca      60

agcccccaag ggccagatcg cctcctgatt agacttcgtc accttattga cattgttgaa     120

cagctgaaaa tctatgaaaa tgacttggat cctgaacttc tatcagctcc acaagatgta     180

aaggggcact gtgagcatgc agcttttgcc tgttttcaga aggccaaact caagccatca     240

aaccctggaa acaataagac attcatcatt gacctcgtgg cccagctcag gaggaggctg     300

cctgccagga ggggaggaaa gaaacagaag cacatagcta aatgcccttc ctgtgattcg     360

tatgagaaaa ggacacccaa agaattccta gaaagactaa aatggctcct tcaaaagatg     420

attcatcagc atctctccta g                                               441


<210> 67
<211> 447
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-1

<400> 67
Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      
Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          
Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              
Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  
Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  
Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      
Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         
Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             
Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 
Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 
Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     
Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         
Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             
Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 
Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 
Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     
Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         
Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             
Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 
Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 
Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     
His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         
Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             
Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 
Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 
Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     
Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         
Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         

<210> 68
<211> 1344
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-1

<400> 68
atgaaagtgt tactcagact tatttgtttc atagctctac tgatttcttc tctggaggct      60

gataaatgca aggaacgtga agaaaaaata attttagtgt catctgcaaa tgaaattgat     120

gttcgtccct gtcctcttaa cccaaatgaa cacaaaggca ctataacttg gtataaagat     180

gacagcaaga cacctgtatc tacagaacaa gcctccagga ttcatcaaca caaagagaaa     240

ctttggtttg ttcctgctaa ggtggaggat tcaggacatt actattgcgt ggtaagaaat     300

tcatcttact gcctcagaat taaaataagt gcaaaatttg tggagaatga gcctaactta     360

tgttataatg cacaagccat atttaagcag aaactacccg ttgcaggaga cggaggactt     420

gtgtgccctt atatggagtt ttttaaaaat gaaaataatg agttacctaa attacagtgg     480

tataaggatt gcaaacctct acttcttgac aatatacact ttagtggagt caaagatagg     540

ctcatcgtga tgaatgtggc tgaaaagcat agagggaact atacttgtca tgcatcctac     600

acatacttgg gcaagcaata tcctattacc cgggtaatag aatttattac tctagaggaa     660

aacaaaccca caaggcctgt gattgtgagc ccagctaatg agacaatgga agtagacttg     720

ggatcccaga tacaattgat ctgtaatgtc accggccagt tgagtgacat tgcttactgg     780

aagtggaatg ggtcagtaat tgatgaagat gacccagtgc taggggaaga ctattacagt     840

gtggaaaatc ctgcaaacaa aagaaggagt accctcatca cagtgcttaa tatatcggaa     900

attgaaagta gattttataa acatccattt acctgttttg ccaagaatac acatggtata     960

gatgcagcat atatccagtt aatatatcca gtcactaatt tccagaagca catgattggt    1020

atatgtgtca cgttgacagt cataattgtg tgttctgttt tcatctataa aatcttcaag    1080

attgacattg tgctttggta cagggattcc tgctatgatt ttctcccaat aaaagcttca    1140

gatggaaaga cctatgacgc atatatactg tatccaaaga ctgttgggga agggtctacc    1200

tctgactgtg atatttttgt gtttaaagtc ttgcctgagg tcttggaaaa acagtgtgga    1260

tataagctgt tcatttatgg aagggatgac tacgttgggg aaggtatgtg tgtaatggaa    1320

cagagtaaag gcttattgtt gtaa                                           1344


<210> 69
<211> 576
<212> PRT
<213> Mus musculus


<220> 
<223> IL-1

<400> 69
Met Glu Asn Met Lys Val Leu Leu Gly Leu Ile Cys Leu Met Val Pro 
1               5                   10                  15      
Leu Leu Ser Leu Glu Ile Asp Val Cys Thr Glu Tyr Pro Asn Gln Ile 
            20                  25                  30          
Val Leu Phe Leu Ser Val Asn Glu Ile Asp Ile Arg Lys Cys Pro Leu 
        35                  40                  45              
Thr Pro Asn Lys Met His Gly Asp Thr Ile Ile Trp Tyr Lys Asn Asp 
    50                  55                  60                  
Ser Lys Thr Pro Ile Ser Ala Asp Arg Asp Ser Arg Ile His Gln Gln 
65                  70                  75                  80  
Asn Glu His Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly Tyr 
                85                  90                  95      
Tyr Tyr Cys Ile Val Arg Asn Ser Thr Tyr Cys Leu Lys Thr Lys Val 
            100                 105                 110         
Thr Val Thr Val Leu Glu Asn Asp Pro Gly Leu Cys Tyr Ser Thr Gln 
        115                 120                 125             
Ala Thr Phe Pro Gln Arg Leu His Ile Ala Gly Asp Gly Ser Leu Val 
    130                 135                 140                 
Cys Pro Tyr Val Ser Tyr Phe Lys Asp Glu Asn Asn Glu Leu Pro Glu 
145                 150                 155                 160 
Val Gln Trp Tyr Lys Asn Cys Lys Pro Leu Leu Leu Asp Asn Val Ser 
                165                 170                 175     
Phe Phe Gly Val Lys Asp Lys Leu Leu Val Arg Asn Val Ala Glu Glu 
            180                 185                 190         
His Arg Gly Asp Tyr Ile Cys Arg Met Ser Tyr Thr Phe Arg Gly Lys 
        195                 200                 205             
Gln Tyr Pro Val Thr Arg Val Ile Gln Phe Ile Thr Ile Asp Glu Asn 
    210                 215                 220                 
Lys Arg Asp Arg Pro Val Ile Leu Ser Pro Arg Asn Glu Thr Ile Glu 
225                 230                 235                 240 
Ala Asp Pro Gly Ser Met Ile Gln Leu Ile Cys Asn Val Thr Gly Gln 
                245                 250                 255     
Phe Ser Asp Leu Val Tyr Trp Lys Trp Asn Gly Ser Glu Ile Glu Trp 
            260                 265                 270         
Asn Asp Pro Phe Leu Ala Glu Asp Tyr Gln Phe Val Glu His Pro Ser 
        275                 280                 285             
Thr Lys Arg Lys Tyr Thr Leu Ile Thr Thr Leu Asn Ile Ser Glu Val 
    290                 295                 300                 
Lys Ser Gln Phe Tyr Arg Tyr Pro Phe Ile Cys Val Val Lys Asn Thr 
305                 310                 315                 320 
Asn Ile Phe Glu Ser Ala His Val Gln Leu Ile Tyr Pro Val Pro Asp 
                325                 330                 335     
Phe Lys Asn Tyr Leu Ile Gly Gly Phe Ile Ile Leu Thr Ala Thr Ile 
            340                 345                 350         
Val Cys Cys Val Cys Ile Tyr Lys Val Phe Lys Val Asp Ile Val Leu 
        355                 360                 365             
Trp Tyr Arg Asp Ser Cys Ser Gly Phe Leu Pro Ser Lys Ala Ser Asp 
    370                 375                 380                 
Gly Lys Thr Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Leu Gly Glu 
385                 390                 395                 400 
Gly Ser Phe Ser Asp Leu Asp Thr Phe Val Phe Lys Leu Leu Pro Glu 
                405                 410                 415     
Val Leu Glu Gly Gln Phe Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp 
            420                 425                 430         
Asp Tyr Val Gly Glu Asp Thr Ile Glu Val Thr Asn Glu Asn Val Lys 
        435                 440                 445             
Lys Ser Arg Arg Leu Ile Ile Ile Leu Val Arg Asp Met Gly Gly Phe 
    450                 455                 460                 
Ser Trp Leu Gly Gln Ser Ser Glu Glu Gln Ile Ala Ile Tyr Asn Ala 
465                 470                 475                 480 
Leu Ile Gln Glu Gly Ile Lys Ile Val Leu Leu Glu Leu Glu Lys Ile 
                485                 490                 495     
Gln Asp Tyr Glu Lys Met Pro Asp Ser Ile Gln Phe Ile Lys Gln Lys 
            500                 505                 510         
His Gly Val Ile Cys Trp Ser Gly Asp Phe Gln Glu Arg Pro Gln Ser 
        515                 520                 525             
Ala Lys Thr Arg Phe Trp Lys Asn Leu Arg Tyr Gln Met Pro Ala Gln 
    530                 535                 540                 
Arg Arg Ser Pro Leu Ser Lys His Arg Leu Leu Thr Leu Asp Pro Val 
545                 550                 555                 560 
Arg Asp Thr Lys Glu Lys Leu Pro Ala Ala Thr His Leu Pro Leu Gly 
                565                 570                 575     



<210> 70
<211> 1731
<212> DNA
<213> Mus musculus


<220> 
<223> IL-1

<400> 70
atggagaata tgaaagtgct actggggctc atttgtctca tggtgcctct gctgtcgctg      60

gagattgacg tatgtacaga atatccaaat cagatcgttt tgtttttatc tgtaaatgaa     120

attgatattc gcaagtgtcc tcttactcca aataaaatgc acggcgacac cataatttgg     180

tacaagaatg acagcaagac ccccatatca gcggaccggg actccaggat tcatcagcag     240

aatgaacatc tttggtttgt acctgccaag gtggaggact caggatatta ctattgtata     300

gtaagaaact caacttactg cctcaaaact aaagtaaccg taactgtgtt agagaatgac     360

cctggcttgt gttacagcac acaggccacc ttcccacagc ggctccacat tgccggggat     420

ggaagtcttg tgtgccctta tgtgagttat tttaaagatg aaaataatga gttacccgag     480

gtccagtggt ataagaactg taaacctctg cttcttgaca acgtgagctt cttcggagta     540

aaagataaac tgttggtgag gaatgtggct gaagagcaca gaggggacta tatatgccgt     600

atgtcctata cgttccgggg gaagcaatat ccggtcacac gagtaataca atttatcaca     660

atagatgaaa acaagaggga cagacctgtt atcctgagcc ctcggaatga gacgatcgaa     720

gctgacccag gatcaatgat acaactgatc tgcaacgtca cgggccagtt ctcagacctt     780

gtctactgga agtggaatgg atcagaaatt gaatggaatg atccatttct agctgaagac     840

tatcaatttg tggaacatcc ttcaaccaaa agaaaataca cactcattac aacacttaac     900

atttcagaag ttaaaagcca gttttatcgc tatccgttta tctgtgttgt taagaacaca     960

aatatttttg agtcggcgca tgtgcagtta atatacccag tccctgactt caagaattac    1020

ctcatcgggg gctttatcat cctcacggct acaattgtat gctgtgtgtg catctataaa    1080

gtcttcaagg ttgacatagt gctttggtac agggactcct gctctggttt tcttccttca    1140

aaagcttcag atggaaagac atacgatgcc tatattcttt atcccaagac cctgggagag    1200

gggtccttct cagacttaga tacttttgtt tttaaactgt tgcctgaggt cttggaggga    1260

cagtttggat acaagctgtt catttatgga agggatgact atgttggaga agataccatc    1320

gaggttacta atgaaaatgt aaagaaaagc aggaggctga ttatcattct agtgagagat    1380

atgggaggct tcagctggct gggccagtca tctgaagagc aaatagccat atacaatgct    1440

ctcatccagg aaggaattaa aatcgtcctg cttgagttgg agaaaatcca agactatgag    1500

aaaatgccag attctattca gttcattaag cagaaacacg gagtcatttg ctggtcagga    1560

gactttcaag aaagaccaca gtctgcaaag accaggttct ggaaaaactt aagataccag    1620

atgccagccc aacggagatc accattgtct aaacaccgct tactaaccct ggatcctgtg    1680

cgggacacta aggagaaact gccggcagca acacacttac cactcggcta g             1731


<210> 71
<211> 479
<212> PRT
<213> Homo sapiens


<220> 
<223> BCL-6

<400> 71
Met Gly Ser Pro Ala Ala Pro Glu Gly Ala Leu Gly Tyr Val Arg Glu 
1               5                   10                  15      
Phe Thr Arg His Ser Ser Asp Val Leu Gly Asn Leu Asn Glu Leu Arg 
            20                  25                  30          
Leu Arg Gly Ile Leu Thr Asp Val Thr Leu Leu Val Gly Gly Gln Pro 
        35                  40                  45              
Leu Arg Ala His Lys Ala Val Leu Ile Ala Cys Ser Gly Phe Phe Tyr 
    50                  55                  60                  
Ser Ile Phe Arg Gly Arg Ala Gly Val Gly Val Asp Val Leu Ser Leu 
65                  70                  75                  80  
Pro Gly Gly Pro Glu Ala Arg Gly Phe Ala Pro Leu Leu Asp Phe Met 
                85                  90                  95      
Tyr Thr Ser Arg Leu Arg Leu Ser Pro Ala Thr Ala Pro Ala Val Leu 
            100                 105                 110         
Ala Ala Ala Thr Tyr Leu Gln Met Glu His Val Val Gln Ala Cys His 
        115                 120                 125             
Arg Phe Ile Gln Ala Ser Tyr Glu Pro Leu Gly Ile Ser Leu Arg Pro 
    130                 135                 140                 
Leu Glu Ala Glu Pro Pro Thr Pro Pro Thr Ala Pro Pro Pro Gly Ser 
145                 150                 155                 160 
Pro Arg Arg Ser Glu Gly His Pro Asp Pro Pro Thr Glu Ser Arg Ser 
                165                 170                 175     
Cys Ser Gln Gly Pro Pro Ser Pro Ala Ser Pro Asp Pro Lys Ala Cys 
            180                 185                 190         
Asn Trp Lys Lys Tyr Lys Tyr Ile Val Leu Asn Ser Gln Ala Ser Gln 
        195                 200                 205             
Ala Gly Ser Leu Val Gly Glu Arg Ser Ser Gly Gln Pro Cys Pro Gln 
    210                 215                 220                 
Ala Arg Leu Pro Ser Gly Asp Glu Ala Ser Ser Ser Ser Ser Ser Ser 
225                 230                 235                 240 
Ser Ser Ser Ser Glu Glu Gly Pro Ile Pro Gly Pro Gln Ser Arg Leu 
                245                 250                 255     
Ser Pro Thr Ala Ala Thr Val Gln Phe Lys Cys Gly Ala Pro Ala Ser 
            260                 265                 270         
Thr Pro Tyr Leu Leu Thr Ser Gln Ala Gln Asp Thr Ser Gly Ser Pro 
        275                 280                 285             
Ser Glu Arg Ala Arg Pro Leu Pro Gly Ser Glu Phe Phe Ser Cys Gln 
    290                 295                 300                 
Asn Cys Glu Ala Val Ala Gly Cys Ser Ser Gly Leu Asp Ser Leu Val 
305                 310                 315                 320 
Pro Gly Asp Glu Asp Lys Pro Tyr Lys Cys Gln Leu Cys Arg Ser Ser 
                325                 330                 335     
Phe Arg Tyr Lys Gly Asn Leu Ala Ser His Arg Thr Val His Thr Gly 
            340                 345                 350         
Glu Lys Pro Tyr His Cys Ser Ile Cys Gly Ala Arg Phe Asn Arg Pro 
        355                 360                 365             
Ala Asn Leu Lys Thr His Ser Arg Ile His Ser Gly Glu Lys Pro Tyr 
    370                 375                 380                 
Lys Cys Glu Thr Cys Gly Ser Arg Phe Val Gln Val Ala His Leu Arg 
385                 390                 395                 400 
Ala His Val Leu Ile His Thr Gly Glu Lys Pro Tyr Pro Cys Pro Thr 
                405                 410                 415     
Cys Gly Thr Arg Phe Arg His Leu Gln Thr Leu Lys Ser His Val Arg 
            420                 425                 430         
Ile His Thr Gly Glu Lys Pro Tyr His Cys Asp Pro Cys Gly Leu His 
        435                 440                 445             
Phe Arg His Lys Ser Gln Leu Arg Leu His Leu Arg Gln Lys His Gly 
    450                 455                 460                 
Ala Ala Thr Asn Thr Lys Val His Tyr His Ile Leu Gly Gly Pro 
465                 470                 475                 

<210> 72
<211> 1440
<212> DNA
<213> Homo sapiens


<220> 
<223> BCL-6

<400> 72
atgggttccc ccgccgcccc ggagggagcg ctgggctacg tccgcgagtt cactcgccac      60

tcctccgacg tgctgggcaa cctcaacgag ctgcgcctgc gcgggatcct cactgacgtc     120

acgctgctgg ttggcgggca acccctcaga gcacacaagg cagttctcat cgcctgcagt     180

ggcttcttct attcaatttt ccggggccgt gcgggagtcg gggtggacgt gctctctctg     240

cccgggggtc ccgaagcgag aggcttcgcc cctctattgg acttcatgta cacttcgcgc     300

ctgcgcctct ctccagccac tgcaccagca gtcctagcgg ccgccaccta tttgcagatg     360

gagcacgtgg tccaggcatg ccaccgcttc atccaggcca gctatgaacc tctgggcatc     420

tccctgcgcc ccctggaagc agaaccccca acacccccaa cggcccctcc accaggtagt     480

cccaggcgct ccgaaggaca cccagaccca cctactgaat ctcgaagctg cagtcaaggc     540

ccccccagtc cagccagccc tgaccccaag gcctgcaact ggaaaaagta caagtacatc     600

gtgctaaact ctcaggcctc ccaagcaggg agcctggtcg gggagagaag ttctggtcaa     660

ccttgccccc aagccaggct ccccagtgga gacgaggcct ccagcagcag cagcagcagc     720

agcagcagca gtgaagaagg acccattcct ggtccccaga gcaggctctc tccaactgct     780

gccactgtgc agttcaaatg tggggctcca gccagtaccc cctacctcct cacatcccag     840

gctcaagaca cctctggatc accctctgaa cgggctcgtc cactaccggg aagtgaattt     900

ttcagctgcc agaactgtga ggctgtggca gggtgctcat cggggctgga ctccttggtt     960

cctggggacg aagacaaacc ctataagtgt cagctgtgcc ggtcttcgtt ccgctacaag    1020

ggcaaccttg ccagtcatcg tacagtgcac acaggggaaa agccttacca ctgctcaatc    1080

tgcggagccc gttttaaccg gccagcaaac ctgaaaacgc acagccgcat ccattcggga    1140

gagaagccgt ataagtgtga gacgtgcggc tcgcgctttg tacaggtggc acatctgcgg    1200

gcgcacgtgc tgatccacac cggggagaag ccctaccctt gccctacctg cggaacccgc    1260

ttccgccacc tgcagaccct caagagccac gttcgcatcc acaccggaga gaagccttac    1320

cactgcgacc cctgtggcct gcatttccgg cacaagagtc aactgcggct gcatctgcgc    1380

cagaaacacg gagctgctac caacaccaaa gtgcactacc acattctcgg ggggccctag    1440


<210> 73
<211> 707
<212> PRT
<213> Mus musculus


<220> 
<223> BCL-6

<400> 73
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      
Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          
Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              
Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  
Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Ser Pro 
65                  70                  75                  80  
Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      
Leu Arg Glu Gly Asn Ile Met Ala Val Met Thr Thr Ala Met Tyr Leu 
            100                 105                 110         
Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             
Glu Ala Glu Met Ala Pro Ala Leu Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 
Asn Ser Arg Met Leu Met Pro His Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 
Glu Val Val Glu Asn Asn Met Pro Leu Arg Asn Thr Pro Gly Cys Glu 
                165                 170                 175     
Ser Arg Ala Phe Ala Pro Pro Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         
Ala Ser Tyr Pro Met Tyr Ser His Leu Pro Leu Ser Thr Phe Leu Phe 
        195                 200                 205             
Ser Asp Glu Glu Leu Arg Asp Ala Pro Arg Met Pro Val Ala Asn Pro 
    210                 215                 220                 
Phe Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Gln Val Pro 
225                 230                 235                 240 
Asn Glu Tyr Ser Arg Pro Ala Met Glu Val Ser Pro Ser Leu Cys His 
                245                 250                 255     
Ser Asn Ile Tyr Ser Pro Lys Glu Ala Val Pro Glu Glu Ala Arg Ser 
            260                 265                 270         
Asp Ile His Tyr Ser Val Pro Glu Gly Pro Lys Pro Ala Val Pro Ser 
        275                 280                 285             
Ala Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu 
    290                 295                 300                 
Glu Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro 
305                 310                 315                 320 
Asn Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln 
                325                 330                 335     
Lys Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys 
            340                 345                 350         
Asn Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro 
        355                 360                 365             
Thr Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu 
    370                 375                 380                 
Asn Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Ser Glu Gln Ala Glu 
385                 390                 395                 400 
Leu Gly Arg Leu Ser Pro Arg Ala Tyr Pro Ala Pro Pro Ala Cys Gln 
                405                 410                 415     
Pro Pro Met Glu Pro Ala Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu 
            420                 425                 430         
Ser Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn 
        435                 440                 445             
Asn Leu Val Asn Arg Ser Leu Ala Gly Ser Pro Arg Ser Ser Ser Glu 
    450                 455                 460                 
Ser His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly 
465                 470                 475                 480 
Ser Gln Ser Pro Gln His Thr Glu Met Cys Leu His Thr Ala Gly Pro 
                485                 490                 495     
Thr Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser 
            500                 505                 510         
Ser Cys Glu Asn Gly Thr Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe 
        515                 520                 525             
Ser Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp 
    530                 535                 540                 
Lys Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly 
545                 550                 555                 560 
Asn Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg 
                565                 570                 575     
Cys Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr 
            580                 585                 590         
His Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys 
        595                 600                 605             
Gly Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile 
    610                 615                 620                 
His Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe 
625                 630                 635                 640 
Arg His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu 
                645                 650                 655     
Lys Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser 
            660                 665                 670         
Gln Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr 
        675                 680                 685             
Lys Val Gln Tyr Arg Val Ser Ala Ala Asp Leu Pro Pro Glu Leu Pro 
    690                 695                 700                 
Lys Ala Cys 
705         

<210> 74
<211> 2124
<212> DNA
<213> Mus musculus


<220> 
<223> BCL-6

<400> 74
atggcctccc cggctgacag ctgtatccag tttacccggc acgctagtga tgttcttctc      60

aaccttaatc gcctccggag tcgggacatc ttgacggacg ttgtcatcgt ggtgagccgt     120

gagcagttta gagcccataa gacagtgctc atggcctgca gcggcctgtt ctacagtatc     180

ttcactgacc agttgaaatg caaccttagt gtaatcaatc tagatcctga aatcagccct     240

gaggggtttt gcatcctcct ggacttcatg tacacatcta ggctcaacct gagggaaggc     300

aatatcatgg cggtgatgac cacagccatg tacctgcaga tggagcatgt tgtcgacaca     360

tgcaggaagt tcatcaaggc cagtgaagca gaaatggccc ctgcacttaa acctccccgt     420

gaagagttcc tgaacagccg gatgctgatg ccccatgaca tcatggccta ccgaggtcgt     480

gaggtcgtgg agaacaatat gccactgaga aatactcccg ggtgtgagag cagagctttt     540

gctcctcctc tgtacagtgg cctgtcaaca ccaccagcct cttatcccat gtacagccat     600

ctcccgctca gcaccttcct cttctctgat gaggagctcc gagatgcccc ccgaatgcct     660

gtggccaacc cttttcccaa ggagcgtgcc ctcccctgcg acagtgccag gcaagtccct     720

aatgagtata gcaggccagc catggaggtg tcccccagtt tgtgtcacag caacatctac     780

tcgcccaagg aggcagtccc agaggaggct cggagtgaca tacactacag tgtgcctgag     840

ggccccaagc ctgctgtccc ttctgctcgg aatgctccat acttcccctg tgacaaagcc     900

agcaaagaag aagagagacc ttcttcggag gatgagattg ccctgcattt cgagcccccc     960

aatgcaccct tgaaccggaa gggtctggtt agtccccaga gtccccagaa atccgactgc    1020

cagcccaact cacccacaga gtcctgcagc agcaagaacg cctgcatcct tcaggcctct    1080

ggctctccgc cagccaagag ccccactgac ccgaaagcct gcaactggaa gaagtataag    1140

ttcatcgttc tcaacagcct caatcagaat gccaaacccg agggctctga gcaggcagag    1200

ctgggtcgcc tctcccctcg agcctaccct gcaccgcccg cttgccagcc gcctatggag    1260

cccgcgaacc ttgatctcca gtccccgacc aagctcagtg ccagtgggga ggactctacc    1320

atcccccaag ccagccggct caataatctc gtgaacaggt ccctggcagg ctccccccga    1380

agcagcagtg agagtcactc accactctac atgcaccccc caaagtgcac atcctgcggc    1440

tctcagtccc cacagcatac agagatgtgc ctccatactg ctgggcccac gttcccggag    1500

gagatggggg aaacccagtc agagtattcg gattctagct gtgagaatgg gaccttcttc    1560

tgcaacgaat gtgactgccg tttctctgag gaggcctcgc tcaagaggca cacgctgcag    1620

acgcacagtg acaaaccata caaatgtgat cgctgccagg cctccttccg ctacaagggc    1680

aacctcgcca gccacaagac tgtccacacg ggtgagaaac cctatcgctg taacatttgt    1740

ggagcgcagt tcaatcggcc agccaacctg aagacccaca ctcgaattca ctctggagaa    1800

aagccctaca aatgtgaaac ctgtggggcc aggtttgttc aggtggccca cctccgtgcc    1860

cacgtgctca tccacactgg agagaagccg tacccctgtg aaatctgtgg cactcgcttc    1920

cggcaccttc agactctgaa gagccatctg cgcatccaca caggagagaa accttaccat    1980

tgtgagaagt gtaacctgca ctttcgtcac aaaagccaac tgcgacttca tttgcgccag    2040

aagcacggcg ccatcaccaa caccaaggtg caataccgcg tgtcggccgc tgacctgcct    2100

ccggagctcc ccaaagcctg ctga                                           2124


<210> 75
<211> 233
<212> PRT
<213> Homo sapiens


<220> 
<223> BCLXL

<400> 75
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         
Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             

<210> 76
<211> 702
<212> DNA
<213> Homo sapiens


<220> 
<223> BCLXL

<400> 76
atgtctcaga gcaaccggga gctggtggtt gactttctct cctacaagct ttcccagaaa      60

ggatacagct ggagtcagtt tagtgatgtg gaagagaaca ggactgaggc cccagaaggg     120

actgaatcgg agatggagac ccccagtgcc atcaatggca acccatcctg gcacctggca     180

gacagccccg cggtgaatgg agccactggc cacagcagca gtttggatgc ccgggaggtg     240

atccccatgg cagcagtaaa gcaagcgctg agggaggcag gcgacgagtt tgaactgcgg     300

taccggcggg cattcagtga cctgacatcc cagctccaca tcaccccagg gacagcatat     360

cagagctttg aacaggtagt gaatgaactc ttccgggatg gggtaaactg gggtcgcatt     420

gtggcctttt tctccttcgg cggggcactg tgcgtggaaa gcgtagacaa ggagatgcag     480

gtattggtga gtcggatcgc agcttggatg gccacttacc tgaatgacca cctagagcct     540

tggatccagg agaacggcgg ctgggatact tttgtggaac tctatgggaa caatgcagca     600

gccgagagcc gaaagggcca ggaacgcttc aaccgctggt tcctgacggg catgactgtg     660

gccggcgtgg ttctgctggg ctcactcttc agtcggaaat ga                        702


<210> 77
<211> 233
<212> PRT
<213> Mus musculus


<220> 
<223> BCLXL

<400> 77
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      
Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          
Asn Arg Thr Glu Ala Pro Glu Glu Thr Glu Ala Glu Arg Glu Thr Pro 
        35                  40                  45              
Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  
Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  
Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      
Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         
His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             
Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 
Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 
Val Leu Val Ser Arg Ile Ala Ser Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     
His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         
Asp Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             
Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 
Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             

<210> 78
<211> 702
<212> DNA
<213> Mus musculus


<220> 
<223> BCLXL

<400> 78
atgtctcaga gcaaccggga gctggtggtc gactttctct cctacaagct ttcccagaaa      60

ggatacagct ggagtcagtt tagtgatgtc gaagagaata ggactgaggc cccagaagaa     120

actgaagcag agagggagac ccccagtgcc atcaatggca acccatcctg gcacctggcg     180

gatagcccgg ccgtgaatgg agccactggc cacagcagca gtttggatgc gcgggaggtg     240

attcccatgg cagcagtgaa gcaagcgctg agagaggcag gcgatgagtt tgaactgcgg     300

taccggagag cgttcagtga tctaacatcc cagcttcaca taaccccagg gaccgcgtat     360

cagagctttg agcaggtagt gaatgaactc tttcgggatg gagtaaactg gggtcgcatc     420

gtggcctttt tctcctttgg cggggcactg tgcgtggaaa gcgtagacaa ggagatgcag     480

gtattggtga gtcggattgc aagttggatg gccacctatc tgaatgacca cctagagcct     540

tggatccagg agaacggcgg ctgggacact tttgtggatc tctacgggaa caatgcagca     600

gccgagagcc ggaaaggcca ggagcgcttc aaccgctggt tcctgacggg catgactgtg     660

gctggtgtgg ttctgctggg ctcactcttc agtcggaagt ga                        702


<210> 79
<211> 224
<212> PRT
<213> Homo sapiens


<220> 
<223> BCL 2

<400> 79
Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          
Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              
Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  
Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  
Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      
Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         
Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             
Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 
Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 
Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     
Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         
Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             
Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 



<210> 80
<211> 720
<212> DNA
<213> Homo sapiens


<220> 
<223> BCL 2

<400> 80
atggcgcacg ctgggagaac agggtacgat aaccgggaga tagtgatgaa gtacatccat      60

tataagctgt cgcagagggg ctacgagtgg gatgcgggag atgtgggcgc cgcgcccccg     120

ggggccgccc ccgcaccggg catcttctcc tcccagcccg ggcacacgcc ccatccagcc     180

gcatcccggg acccggtcgc caggacctcg ccgctgcaga ccccggctgc ccccggcgcc     240

gccgcggggc ctgcgctcag cccggtgcca cctgtggtcc acctgaccct ccgccaggcc     300

ggcgacgact tctcccgccg ctaccgccgc gacttcgccg agatgtccag ccagctgcac     360

ctgacgccct tcaccgcgcg gggacgcttt gccacggtgg tggaggagct cttcagggac     420

ggggtgaact gggggaggat tgtggccttc tttgagttcg gtggggtcat gtgtgtggag     480

agcgtcaacc gggagatgtc gcccctggtg gacaacatcg ccctgtggat gactgagtac     540

ctgaaccggc acctgcacac ctggatccag gataacggag gctgggatgc ctttgtggaa     600

ctgtacggcc ccagcatgcg gcctctgttt gatttctcct ggctgtctct gaagactctg     660

ctcagtttgg ccctggtggg agcttgcatc accctgggtg cctatctggg ccacaagtga     720


<210> 81
<211> 218
<212> PRT
<213> Mus musculus


<220> 
<223> BCL 2

<400> 81
Met Ala Gln Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      
Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          
Gly Asp Ala Asp Ala Ala Pro Leu Gly Ala Ala Pro Thr Pro Gly Ile 
        35                  40                  45              
Phe Ser Phe Gln Pro Glu Ser Asn Pro Met Pro Ala Val His Arg Asp 
    50                  55                  60                  
Met Ala Ala Arg Thr Ser Pro Leu Arg Pro Leu Val Ala Thr Ala Gly 
65                  70                  75                  80  
Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr Leu Arg Arg 
                85                  90                  95      
Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe Ala Glu Met 
            100                 105                 110         
Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly Arg Phe Ala 
        115                 120                 125             
Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile 
    130                 135                 140                 
Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu Ser Val Asn 
145                 150                 155                 160 
Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp Met Thr Glu 
                165                 170                 175     
Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn Gly Gly Trp 
            180                 185                 190         
Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro Leu Phe Asp 
        195                 200                 205             
Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu 
    210                 215             

<210> 82
<211> 711
<212> DNA
<213> Mus musculus


<220> 
<223> BCL 2

<400> 82
atggcgcaag ccgggagaac agggtatgat aaccgggaga tcgtgatgaa gtacatacat      60

tataagctgt cacagagggg ctacgagtgg gatgctggag atgcggacgc ggcgcccctg     120

ggggctgccc ccacccctgg catcttctcc ttccagcctg agagcaaccc aatgcccgct     180

gtgcaccggg acatggctgc caggacgtct cctctcaggc ccctcgttgc caccgctggg     240

cctgcgctca gccctgtgcc acctgtggtc catctgaccc tccgccgggc tggggatgac     300

ttctctcgtc gctaccgtcg tgacttcgca gagatgtcca gtcagctgca cctgacgccc     360

ttcaccgcga ggggacgctt tgccacggtg gtggaggaac tcttcaggga tggggtgaac     420

tgggggagga ttgtggcctt ctttgagttc ggtggggtca tgtgtgtgga gagcgtcaac     480

agggagatgt cacccctggt ggacaacatc gccctgtgga tgactgagta cctgaaccgg     540

catctgcaca cctggatcca ggataacgga ggctgggatg cctttgtgga actatatggc     600

cccagcatgc gacctctgtt tgatttctcc tggctgtctc tgaagaccct gctcagcctg     660

gccctggtcg gggcctgcat cactctgggt gcatacctgg gccacaagtg a              711


<210> 83
<211> 350
<212> PRT
<213> Homo sapiens


<220> 
<223> MCL1

<400> 83
Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      
Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          
Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              
Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  
Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  
Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      
Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         
Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             
Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 
Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 
Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     
Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         
Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             
Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 
Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 
Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     
Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         
Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             
Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 
Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 
Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     
Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 

<210> 84
<211> 1053
<212> DNA
<213> Homo sapiens


<220> 
<223> MCL1

<400> 84
atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc tctactgtgg gggggccggc      60

ttgggggccg gcagcggcgg cgccacccgc ccgggagggc gacttttggc tacggagaag     120

gaggcctcgg cccggcgaga gataggggga ggggaggccg gcgcggtgat tggcggaagc     180

gccggcgcaa gccccccgtc caccctcacg ccagactccc ggagggtcgc gcggccgccg     240

cccattggcg ccgaggtccc cgacgtcacc gcgacccccg cgaggctgct tttcttcgcg     300

cccacccgcc gcgcggcgcc gcttgaggag atggaagccc cggccgctga cgccatcatg     360

tcgcccgaag aggagctgga cgggtacgag ccggagcctc tcgggaagcg gccggctgtc     420

ctgccgctgc tggagttggt cggggaatct ggtaataaca ccagtacgga cgggtcacta     480

ccctcgacgc cgccgccagc agaggaggag gaggacgagt tgtaccggca gtcgctggag     540

attatctctc ggtaccttcg ggagcaggcc accggcgcca aggacacaaa gccaatgggc     600

aggtctgggg ccaccagcag gaaggcgctg gagaccttac gacgggttgg ggatggcgtg     660

cagcgcaacc acgagacggc cttccaaggc atgcttcgga aactggacat caaaaacgaa     720

gacgatgtga aatcgttgtc tcgagtgatg atccatgttt tcagcgacgg cgtaacaaac     780

tggggcagga ttgtgactct catttctttt ggtgcctttg tggctaaaca cttgaagacc     840

ataaaccaag aaagctgcat cgaaccatta gcagaaagta tcacagacgt tctcgtaagg     900

acaaaacggg actggctagt taaacaaaga ggctgggatg ggtttgtgga gttcttccat     960

gtagaggacc tagaaggtgg catcaggaat gtgctgctgg cttttgcagg tgttgctgga    1020

gtaggagctg gtttggcata tctaataaga tag                                 1053


<210> 85
<211> 331
<212> PRT
<213> Mus musculus


<220> 
<223> MCL 1

<400> 85
Met Phe Gly Leu Arg Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      
Gly Gly Ala Ser Leu Gly Ala Gly Gly Gly Ser Pro Ala Gly Ala Arg 
            20                  25                  30          
Leu Val Ala Glu Glu Ala Lys Ala Arg Arg Glu Gly Gly Gly Glu Ala 
        35                  40                  45              
Ala Leu Leu Pro Gly Ala Arg Val Val Ala Arg Pro Pro Pro Val Gly 
    50                  55                  60                  
Ala Glu Asp Pro Asp Val Thr Ala Ser Ala Glu Arg Arg Leu His Lys 
65                  70                  75                  80  
Ser Pro Gly Leu Leu Ala Val Pro Pro Glu Glu Met Ala Ala Ser Ala 
                85                  90                  95      
Ala Ala Ala Ile Val Ser Pro Glu Glu Glu Leu Asp Gly Cys Glu Pro 
            100                 105                 110         
Glu Ala Ile Gly Lys Arg Pro Ala Val Leu Pro Leu Leu Glu Arg Val 
        115                 120                 125             
Ser Glu Ala Ala Lys Ser Ser Gly Ala Asp Gly Ser Leu Pro Ser Thr 
    130                 135                 140                 
Pro Pro Pro Pro Glu Glu Glu Glu Asp Asp Leu Tyr Arg Gln Ser Leu 
145                 150                 155                 160 
Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly Ser Lys Asp 
                165                 170                 175     
Ser Lys Pro Leu Gly Glu Ala Gly Ala Ala Gly Arg Arg Ala Leu Glu 
            180                 185                 190         
Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His Glu Thr Ala 
        195                 200                 205             
Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu Gly Asp Val 
    210                 215                 220                 
Lys Ser Phe Ser Arg Val Met Val His Val Phe Lys Asp Gly Val Thr 
225                 230                 235                 240 
Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala Phe Val Ala 
                245                 250                 255     
Lys His Leu Lys Ser Val Asn Gln Glu Ser Phe Ile Glu Pro Leu Ala 
            260                 265                 270         
Glu Thr Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp Trp Leu Val 
        275                 280                 285             
Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His Val Gln Asp 
    290                 295                 300                 
Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala Gly Val Ala 
305                 310                 315                 320 
Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
                325                 330     

<210> 86
<211> 996
<212> DNA
<213> Mus musculus


<220> 
<223> MCL1

<400> 86
atgtttggcc tgcggagaaa cgcggtcatc ggcttgaacc tgtactgcgg cggcgccagc      60

ctcggcgcgg gcggcggttc tccggcaggg gcgcgcctgg tggccgagga ggccaaggcg     120

cggcgcgagg ggggagggga ggccgccctg ctgcccggcg cgcgggtggt cgcccggccg     180

ccgcccgtgg gcgccgagga ccccgacgtc accgcgtcgg ccgaaaggcg gctgcataag     240

tcgcccggcc tcctcgccgt gccgcccgag gagatggccg cgtcggccgc cgccgccatc     300

gtgtctccgg aggaggaact ggacggctgc gagccggagg ccatcggcaa gcgcccggcc     360

gtgctgcccc tcctggagcg cgtgagcgag gcggccaaga gctccggggc cgacggctct     420

ctgccctcca cgccgccgcc gcccgaggag gaagaggacg acctataccg ccagtcgctg     480

gagatcatct cgcgctactt gcgggagcag gcgaccggct ccaaggactc gaagcctctg     540

ggcgaggcgg gcgcggcggg ccggagagcg ctggagaccc tgcggcgcgt gggcgacggc     600

gtgcagcgca accacgagac ggccttccag ggcatgctcc ggaaactgga cattaaaaac     660

gaaggcgatg ttaaatcttt ttctcgagta atggtccatg ttttcaaaga tggcgtaaca     720

aactggggca ggattgtgac tcttatttct ttcggtgcct ttgtggccaa acacttaaag     780

agcgtaaacc aagaaagctt catcgaacca ttagcagaaa ctatcacaga tgttcttgta     840

aggacgaaac gggactggct tgtcaaacaa agaggctggg atgggtttgt ggagttcttc     900

cacgtacagg acctagaagg cggcatcaga aatgtgctgc tggcttttgc gggtgttgct     960

ggagtagggg ctggtctggc atatctaata agatag                               996


<210> 87
<211> 153
<212> PRT
<213> Homo sapiens


<220> 
<223> IL-2

<400> 87
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             

<210> 88
<211> 462
<212> DNA
<213> Homo sapiens


<220> 
<223> IL-2

<400> 88
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt      60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat     120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc     180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa     240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta     300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa     360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga     420

tggattacct tttgtcaaag catcatctca acactgactt ga                        462


<210> 89
<211> 146
<212> PRT
<213> Mus musculus


<220> 
<223> IL-2

<400> 89
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 
Glu Ser 
145     

<210> 90
<211> 510
<212> DNA
<213> Mus musculus


<220> 
<223> IL-2

<400> 90
atgtacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc      60

gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag     120

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc     180

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg     240

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg     300

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc     360

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc     420

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt     480

caaagcatca tctcaacaag ccctcaataa                                      510


<210> 91
<211> 261
<212> PRT
<213> Homo sapiens


<220> 
<223> CD40L

<400> 91
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      
Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          
Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              
Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  
Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  
Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      
Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         
Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             
Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 
Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 
Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     
Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         
Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             
Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 
Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 
Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     
Gly Leu Leu Lys Leu 
            260     

<210> 92
<211> 786
<212> DNA
<213> Homo sapiens


<220> 
<223> CD40L

<400> 92
atgatcgaaa catacaacca aacttctccc cgatctgcgg ccactggact gcccatcagc      60

atgaaaattt ttatgtattt acttactgtt tttcttatca cccagatgat tgggtcagca     120

ctttttgctg tgtatcttca tagaaggttg gacaagatag aagatgaaag gaatcttcat     180

gaagattttg tattcatgaa aacgatacag agatgcaaca caggagaaag atccttatcc     240

ttactgaact gtgaggagat taaaagccag tttgaaggct ttgtgaagga tataatgtta     300

aacaaagagg agacgaagaa agaaaacagc tttgaaatgc aaaaaggtga tcagaatcct     360

caaattgcgg cacatgtcat aagtgaggcc agcagtaaaa caacatctgt gttacagtgg     420

gctgaaaaag gatactacac catgagcaac aacttggtaa ccctggaaaa tgggaaacag     480

ctgaccgtta aaagacaagg actctattat atctatgccc aagtcacctt ctgttccaat     540

cgggaagctt cgagtcaagc tccatttata gccagcctct gcctaaagtc ccccggtaga     600

ttcgagagaa tcttactcag agctgcaaat acccacagtt ccgccaaacc ttgcgggcaa     660

caatccattc acttgggagg agtatttgaa ttgcaaccag gtgcttcggt gtttgtcaat     720

gtgactgatc caagccaagt gagccatggc actggcttca cgtcctttgg cttactcaaa     780

ctctga                                                                786


<210> 93
<211> 260
<212> PRT
<213> Mus musculus


<220> 
<223> CD40L

<400> 93
Met Ile Glu Thr Tyr Ser Gln Pro Ser Pro Arg Ser Val Ala Thr Gly 
1               5                   10                  15      
Leu Pro Ala Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          
Ile Thr Gln Met Ile Gly Ser Val Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              
Arg Leu Asp Lys Val Glu Glu Glu Val Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  
Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys Gly Glu Gly Ser Leu Ser 
65                  70                  75                  80  
Leu Leu Asn Cys Glu Glu Met Arg Arg Gln Phe Glu Asp Leu Val Lys 
                85                  90                  95      
Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys Glu Asn Ser Phe Glu Met 
            100                 105                 110         
Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser Glu 
        115                 120                 125             
Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr 
    130                 135                 140                 
Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln Leu 
145                 150                 155                 160 
Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe 
                165                 170                 175     
Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly Leu 
            180                 185                 190         
Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala 
        195                 200                 205             
Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His Leu 
    210                 215                 220                 
Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn Val 
225                 230                 235                 240 
Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe Gly 
                245                 250                 255     
Leu Leu Lys Leu 
            260 

<210> 94
<211> 783
<212> DNA
<213> Mus musculus


<220> 
<223> CD40L

<400> 94
atgatagaaa catacagcca accttccccc agatccgtgg caactggact tccagcgagc      60

atgaagattt ttatgtattt acttactgtt ttccttatca cccaaatgat tggatctgtg     120

ctttttgctg tgtatcttca tagaagattg gataaggtcg aagaggaagt aaaccttcat     180

gaagattttg tattcataaa aaagctaaag agatgcaaca aaggagaagg atctttatcc     240

ttgctgaact gtgaggagat gagaaggcaa tttgaagacc ttgtcaagga tataacgtta     300

aacaaagaag agaaaaaaga aaacagcttt gaaatgcaaa gaggtgatga ggatcctcaa     360

attgcagcac acgttgtaag cgaagccaac agtaatgcag catccgttct acagtgggcc     420

aagaaaggat attataccat gaaaagcaac ttggtaatgc ttgaaaatgg gaaacagctg     480

acggttaaaa gagaaggact ctattatgtc tacactcaag tcaccttctg ctctaatcgg     540

gagccttcga gtcaacgccc attcatcgtc ggcctctggc tgaagcccag cagtggatct     600

gagagaatct tactcaaggc ggcaaatacc cacagttcct cccagctttg cgagcagcag     660

tctgttcact tgggcggagt gtttgaatta caagctggtg cttctgtgtt tgtcaacgtg     720

actgaagcaa gccaagtgat ccacagagtt ggcttctcat cttttggctt actcaaactc     780

tga                                                                   783


<210> 95
<211> 151
<212> PRT
<213> Homo sapiens


<220> 
<223> GITR-L

<400> 95
Met Cys Leu Ser His Leu Glu Asn Met Pro Leu Ser His Ser Arg Thr 
1               5                   10                  15      
Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu Trp Leu Phe Cys Ser Ile 
            20                  25                  30          
Val Met Leu Leu Phe Leu Cys Ser Phe Ser Trp Leu Ile Phe Ile Phe 
        35                  40                  45              
Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
    50                  55                  60                  
Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
65                  70                  75                  80  
Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
                85                  90                  95      
Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
            100                 105                 110         
Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
        115                 120                 125             
Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
    130                 135                 140                 
Gly Asp Thr Ile Asp Leu Ile 
145                 150     

<210> 96
<211> 534
<212> DNA
<213> Homo sapiens


<220> 
<223> GITR-L

<400> 96
atgtgtttga gccacttgga aaatatgcct ttaagccatt caagaactca aggagctcag      60

agatcatcct ggaagctgtg gctcttttgc tcaatagtta tgttgctatt tctttgctcc     120

ttcagttggc taatctttat ttttctccaa ttagagactg ctaaggagcc ctgtatggct     180

aagtttggac cattaccctc aaaatggcaa atggcatctt ctgaacctcc ttgcgtgaat     240

aaggtgtctg actggaagct ggagatactt cagaatggct tatatttaat ttatggccaa     300

gtggctccca atgcaaacta caatgatgta gctccttttg aggtgcggct gtataaaaac     360

aaagacatga tacaaactct aacaaacaaa tctaaaatcc aaaatgtagg agggacttat     420

gaattgcatg ttggggacac catagacttg atattcaact ctgagcatca ggttctaaaa     480

aataatacat actggggtat cattttacta gcaaatcccc aattcatctc ctag           534


<210> 97
<211> 164
<212> PRT
<213> Mus musculus


<220> 
<223> GITR-L

<400> 97
Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      
Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          
Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              
Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  
Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  
Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      
Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         
Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             
Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 
Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr 
145                 150                 155                 160 
Trp Gly Ile Ile 
                

<210> 98
<211> 522
<212> DNA
<213> Mus musculus


<220> 
<223> GITR-L

<400> 98
atggaggaaa tgcctttgag agaatcaagt cctcaaaggg cagagaggtg caagaagtca      60

tggctcttgt gcatagtggc tctgttactg atgttgctct gttctttggg tacactgatc     120

tatacttcac tcaagccaac tgccatcgag tcctgcatgg ttaagtttga actatcatcc     180

tcaaaatggc acatgacatc tcccaaacct cactgtgtga atacgacatc tgatgggaag     240

ctgaagatac tgcagagtgg cacatattta atctacggcc aagtgattcc tgtggataag     300

aaatacataa aagacaatgc ccccttcgta gtacagatat ataaaaagaa tgatgtccta     360

caaactctaa tgaatgattt tcaaatcttg cctataggag gggtttatga actgcatgct     420

ggagataaca tatatctgaa gttcaactct aaagaccata ttcagaaaac taacacatac     480

tgggggatca tcttaatgcc tgatctacca ttcatctctt ag                        522


<210> 99
<211> 464
<212> PRT
<213> Homo sapiens


<220> 
<223> CD66a

<400> 99
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          
Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  
Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     
Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             
Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 
Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     
Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 
Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 
Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     
Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         
Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             
Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 
Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 
Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     
Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         
Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             
Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 



<210> 100
<211> 1395
<212> DNA
<213> Homo sapiens


<220> 
<223> CD66a

<400> 100
atggggcacc tctcagcccc acttcacaga gtgcgtgtac cctggcaggg gcttctgctc      60

acagcctcac ttctaacctt ctggaacccg cccaccactg cccagctcac tactgaatcc     120

atgccattca atgttgcaga ggggaaggag gttcttctcc ttgtccacaa tctgccccag     180

caactttttg gctacagctg gtacaaaggg gaaagagtgg atggcaaccg tcaaattgta     240

ggatatgcaa taggaactca acaagctacc ccagggcccg caaacagcgg tcgagagaca     300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctac     360

accctacaag tcataaagtc agatcttgtg aatgaagaag caactggaca gttccatgta     420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccctgt ggaggacaag     480

gatgctgtgg ccttcacctg tgaacctgag actcaggaca caacctacct gtggtggata     540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc     600

actctactca gtgtcacaag gaatgacaca ggaccctatg agtgtgaaat acagaaccca     660

gtgagtgcga accgcagtga cccagtcacc ttgaatgtca cctatggccc ggacaccccc     720

accatttccc cttcagacac ctattaccgt ccaggggcaa acctcagcct ctcctgctat     780

gcagcctcta acccacctgc acagtactcc tggcttatca atggaacatt ccagcaaagc     840

acacaagagc tctttatccc taacatcact gtgaataata gtggatccta tacctgccac     900

gccaataact cagtcactgg ctgcaacagg accacagtca agacgatcat agtcactgag     960

ctaagtccag tagtagcaaa gccccaaatc aaagccagca agaccacagt cacaggagat    1020

aaggactctg tgaacctgac ctgctccaca aatgacactg gaatctccat ccgttggttc    1080

ttcaaaaacc agagtctccc gtcctcggag aggatgaagc tgtcccaggg caacaccacc    1140

ctcagcataa accctgtcaa gagggaggat gctgggacgt attggtgtga ggtcttcaac    1200

ccaatcagta agaaccaaag cgaccccatc atgctgaacg taaactataa tgctctacca    1260

caagaaaatg gcctctcacc tggggccatt gctggcattg tgattggagt agtggccctg    1320

gttgctctga tagcagtagc cctggcatgt tttctgcatt tcgggaagac cggcagctca    1380

ggaccactcc aatga                                                     1395


<210> 101
<211> 458
<212> PRT
<213> Mus musculus


<220> 
<223> CD66a

<400> 101
Met Glu Leu Ala Ser Ala His Leu His Lys Gly Gln Val Pro Trp Gly 
1               5                   10                  15      
Gly Leu Leu Leu Thr Ala Ser Leu Leu Ala Ser Trp Ser Pro Ala Thr 
            20                  25                  30          
Thr Ala Glu Val Thr Ile Glu Ala Val Pro Pro Gln Val Ala Glu Asp 
        35                  40                  45              
Asn Asn Val Leu Leu Leu Val His Asn Leu Pro Leu Ala Leu Gly Ala 
    50                  55                  60                  
Phe Ala Trp Tyr Lys Gly Asn Thr Thr Ala Ile Asp Lys Glu Ile Ala 
65                  70                  75                  80  
Arg Phe Val Pro Asn Ser Asn Met Asn Phe Thr Gly Gln Ala Tyr Ser 
                85                  90                  95      
Gly Arg Glu Ile Ile Tyr Ser Asn Gly Ser Leu Leu Phe Gln Met Ile 
            100                 105                 110         
Thr Met Lys Asp Met Gly Val Tyr Thr Leu Asp Met Thr Asp Glu Asn 
        115                 120                 125             
Tyr Arg Arg Thr Gln Ala Thr Val Arg Phe His Val His Pro Ile Leu 
    130                 135                 140                 
Leu Lys Pro Asn Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Gly Asp 
145                 150                 155                 160 
Asp Ser Val Ser Leu Thr Cys Asp Ser Tyr Thr Asp Pro Asp Asn Ile 
                165                 170                 175     
Asn Tyr Leu Trp Ser Arg Asn Gly Glu Ser Leu Ser Glu Gly Asp Arg 
            180                 185                 190         
Leu Lys Leu Ser Glu Gly Asn Arg Thr Leu Thr Leu Leu Asn Val Thr 
        195                 200                 205             
Arg Asn Asp Thr Gly Pro Tyr Val Cys Glu Thr Arg Asn Pro Val Ser 
    210                 215                 220                 
Val Asn Arg Ser Asp Pro Phe Ser Leu Asn Ile Ile Tyr Gly Pro Asp 
225                 230                 235                 240 
Thr Pro Ile Ile Ser Pro Ser Asp Ile Tyr Leu His Pro Gly Ser Asn 
                245                 250                 255     
Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Phe 
            260                 265                 270         
Trp Leu Ile Asn Glu Lys Pro His Ala Ser Ser Gln Glu Leu Phe Ile 
        275                 280                 285             
Pro Asn Ile Thr Thr Asn Asn Ser Gly Thr Tyr Thr Cys Phe Val Asn 
    290                 295                 300                 
Asn Ser Val Thr Gly Leu Ser Arg Thr Thr Val Lys Asn Ile Thr Val 
305                 310                 315                 320 
Leu Glu Pro Val Thr Gln Pro Phe Leu Gln Val Thr Asn Thr Thr Val 
                325                 330                 335     
Lys Glu Leu Asp Ser Val Thr Leu Thr Cys Leu Ser Asn Asp Ile Gly 
            340                 345                 350         
Ala Asn Ile Gln Trp Leu Phe Asn Ser Gln Ser Leu Gln Leu Thr Glu 
        355                 360                 365             
Arg Met Thr Leu Ser Gln Asn Asn Ser Ile Leu Arg Ile Asp Pro Ile 
    370                 375                 380                 
Lys Arg Glu Asp Ala Gly Glu Tyr Gln Cys Glu Ile Ser Asn Pro Val 
385                 390                 395                 400 
Ser Val Arg Arg Ser Asn Ser Ile Lys Leu Asp Ile Ile Phe Asp Pro 
                405                 410                 415     
Thr Gln Gly Gly Leu Ser Asp Gly Ala Ile Ala Gly Ile Val Ile Gly 
            420                 425                 430         
Val Val Ala Gly Val Ala Leu Ile Ala Gly Leu Ala Tyr Phe Leu Tyr 
        435                 440                 445             
Ser Arg Lys Ser Gly Gly Ser Gly Ser Phe 
    450                 455             

<210> 102
<211> 1377
<212> DNA
<213> Mus musculus


<220> 
<223> CD66a

<400> 102
atggagctgg cctcagcaca tctccacaaa gggcaggttc cctggggagg actactgctc      60

acagcctcac ttttagcctc ctggagccct gccaccactg ctgaagtcac cattgaggct     120

gtgccgcccc aggttgctga agacaacaat gttcttctac ttgttcacaa tctgcccctg     180

gcgcttggag cctttgcctg gtacaaggga aacactacgg ctatagacaa agaaattgca     240

cgatttgtac caaatagtaa tatgaatttc acggggcaag catacagcgg cagagagata     300

atatacagca atggatccct gctcttccaa atgatcacca tgaaggatat gggagtctac     360

acactagata tgacagatga aaactatcgt cgtactcagg cgactgtgcg atttcatgta     420

caccccatat tattaaagcc caacatcaca agcaacaact ccaatcccgt ggagggtgac     480

gactccgtat cattaacctg tgactcttac actgaccctg ataatataaa ctacctgtgg     540

agcagaaatg gtgaaagcct ttcagaaggt gacaggctga agctgtctga gggcaacagg     600

actctcactt tactcaatgt cacgaggaat gacacaggac cctatgtgtg tgaaacccgg     660

aatccagtga gtgtcaaccg aagtgaccca ttcagcctga acattatcta tggtccggac     720

accccgatta tatccccctc agatatttat ttgcatccag ggtcaaacct caacctctcc     780

tgccatgcag cctctaaccc acctgcacag tacttttggc ttatcaatga gaagccccat     840

gcatcctccc aagagctctt tatccccaac atcactacta ataatagcgg aacctatacc     900

tgcttcgtca ataactctgt cactggcctc agtaggacca cagtcaagaa cattacagtc     960

cttgagccag tgactcagcc cttcctccaa gtcaccaaca ccacagtcaa agaactagac    1020

tctgtgaccc tgacctgctt gtcgaatgac attggagcca acatccagtg gctcttcaat    1080

agccagagtc ttcagctcac agagagaatg acactctccc agaacaacag catcctcaga    1140

atagacccta ttaagaggga agatgccggc gagtatcagt gtgaaatctc gaatccagtc    1200

agcgtcagga ggagcaactc aatcaagctg gacataatat ttgacccaac acaaggaggc    1260

ctctcagatg gcgccattgc tggcatcgtg attggagttg tggctggggt ggctctaata    1320

gcagggctgg catatttcct ctattccagg aagtctggcg gatctggctc cttctga       1377


