                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
 
<120>  SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT

<130>  145021.561352 (001100.PC)

<150>  US 63/180,426
<151>  2021-04-27

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Protein

<400>  1

Gly Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly 
1               5                   10                  15      


Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu 
            20                  25                  30          


Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp 
        35                  40                  45              


Gly Glu Thr Ser Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu 
    50                  55                  60                  


Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu 
65                  70                  75                  80  


Leu Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His 
                85                  90                  95      


Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met 
            100                 105                 110         


Val Leu Val Gly Asn Lys Ser Asp Leu Pro Ser Arg Thr Val Asp Thr 
        115                 120                 125             


Lys Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu 
    130                 135                 140                 


Thr Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu 
145                 150                 155                 160 


Val Arg Glu Ile Arg Lys His Lys Glu Lys 
                165                 170 


<210>  2
<211>  188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Protein

<400>  2

Met Ala Ser Ser His His His His His His Ser Ser Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly 
            20                  25                  30          


Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val 
        35                  40                  45              


Asp Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val 
    50                  55                  60                  


Ile Asp Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln 
65                  70                  75                  80  


Glu Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly 
                85                  90                  95      


Phe Leu Cys Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile 
            100                 105                 110         


His His Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val 
        115                 120                 125             


Pro Met Val Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val 
    130                 135                 140                 


Asp Thr Lys Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe 
145                 150                 155                 160 


Ile Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr 
                165                 170                 175     


Thr Leu Val Arg Glu Ile Arg Lys His Lys Glu Lys 
            180                 185             


<210>  3
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Protein

<400>  3

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Thr 
1               5                   10                  15      


Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys Ser Ala 
            20                  25                  30          


Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro 
        35                  40                  45              


Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr 
    50                  55                  60                  


Ser Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr Ser Ala 
65                  70                  75                  80  


Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Leu Val Phe 
                85                  90                  95      


Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr Arg Glu 
            100                 105                 110         


Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val Leu Val 
        115                 120                 125             


Gly Asn Lys Ser Asp Leu Pro Ser Arg Thr Val Asp Thr Lys Gln Ala 
    130                 135                 140                 


Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val Arg Glu 
                165                 170                 175     


Ile Arg Lys His Lys Glu Lys 
            180             


