                               SEQUENCE LISTING

<110> KALIVIR IMMUNOTHERAPEUTICS, INC.
 
<120> ONCOLYTIC VIRUSES FOR MODIFIED MHC EXPRESSION

<130> 199249-716601

<140>
<141>

<150> 63/182,243
<151> 2021-04-30

<160> 39    

<170> PatentIn version 3.5

<210> 1
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
tcactaattc caaacccacc cgctttttat agtaagtttt tcacccataa ataataaata       60

caataattaa tttctcgtaa aagtagaaaa tatattctaa tttattgcac ggtaaggaag      120

tagatcataa                                                             130


<210> 2
<211> 210
<212> DNA
<213> Cowpox virus

<400> 2
atgttcatca tgcgcgagag catttaccgc gtgatgattg tcattttgta tttgagcttg       60

atttcttcgt ttttggttat ctgctctatg gagcacggct acttccagga gggcatcagc      120

cgcttcaaga tttgtcccta tcattggtat aaacaacaca tgagtttatt gtttcgtcgt      180

tactatcaca agctggatag tatcatctag                                       210


<210> 3
<211> 69
<212> PRT
<213> Cowpox virus

<400> 3
Met Phe Ile Met Arg Glu Ser Ile Tyr Arg Val Met Ile Val Ile Leu 
1               5                   10                  15      


Tyr Leu Ser Leu Ile Ser Ser Phe Leu Val Ile Cys Ser Met Glu His 
            20                  25                  30          


Gly Tyr Phe Gln Glu Gly Ile Ser Arg Phe Lys Ile Cys Pro Tyr His 
        35                  40                  45              


Trp Tyr Lys Gln His Met Ser Leu Leu Phe Arg Arg Tyr Tyr His Lys 
    50                  55                  60                  


Leu Asp Ser Ile Ile 
65                  


<210> 4
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
ggcaaaggag atcctaagaa gccgagaggc aaaatgtcat catatgcatt cttcgtgcaa       60

acttgtcggg aggagcataa gaagaagcac ccagatgctg cagtcaactt cgctgagttt      120

gcaaagaagt gcgctgagag gtggaagacc atggcagcta aagagaaagg aaaatttgaa      180

gatatggcaa aagcggacaa ggcccgttat gaaagagaaa tgaaaaccta tatccctccc      240

aaaggggaga caaaaaagaa gttcaaggac cccaatgcac ccaagaggcc tccttcggcc      300

ttcttcctct tctgctctga gtatcgccca aaaatcaaag gagaacatcc tggcctgtcc      360

attggtgatg ttgcgaagaa actgggagag atgtggaata acactgctgc agatgacaag      420

cagccttatg aaaagaaggc tgcgaagctg aaggaaaaat atgaaaagga tattgctgca      480

tatcgagcta aaggaaagcc tgatgcagca aaaaagggag ttgtcaaggc tgaaaaagcg      540

aagaaaaaga aggaagagga ggaagatgag gaagatgaag aggatgagga ggaggaggaa      600

gatgaagaag atgaagatga agaagaagat gatgatgatg aataa                      645


<210> 5
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
1               5                   10                  15      


Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
            20                  25                  30          


Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala Glu Arg Trp 
        35                  40                  45              


Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
    50                  55                  60                  


Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
65                  70                  75                  80  


Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                85                  90                  95      


Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys Ile 
            100                 105                 110         


Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu 
        115                 120                 125             


Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu 
    130                 135                 140                 


Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
145                 150                 155                 160 


Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys 
                165                 170                 175     


Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu Asp 
            180                 185                 190         


Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
        195                 200                 205             


Glu Asp Asp Asp Asp Glu 
    210                 


<210> 6
<211> 54
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      IgE derived signal sequence

<400> 6
atggactgga catggattct ctttctagtg gccgcagcca caagggtcca ctcc             54


<210> 7
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      IgE derived signal sequence

<400> 7
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210> 8
<211> 699
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atggactgga catggattct ctttctagtg gccgcagcca caagggtcca ctccggcaaa       60

ggagatccta agaagccgag aggcaaaatg tcatcatatg cattcttcgt gcaaacttgt      120

cgggaggagc ataagaagaa gcacccagat gctgcagtca acttcgctga gtttgcaaag      180

aagtgcgctg agaggtggaa gaccatggca gctaaagaga aaggaaaatt tgaagatatg      240

gcaaaagcgg acaaggcccg ttatgaaaga gaaatgaaaa cctatatccc tcccaaaggg      300

gagacaaaaa agaagttcaa ggaccccaat gcacccaaga ggcctccttc ggccttcttc      360

ctcttctgct ctgagtatcg cccaaaaatc aaaggagaac atcctggcct gtccattggt      420

gatgttgcga agaaactggg agagatgtgg aataacactg ctgcagatga caagcagcct      480

tatgaaaaga aggctgcgaa gctgaaggaa aaatatgaaa aggatattgc tgcatatcga      540

gctaaaggaa agcctgatgc agcaaaaaag ggagttgtca aggctgaaaa agcgaagaaa      600

aagaaggaag aggaggaaga tgaggaagat gaagaggatg aggaggagga ggaagatgaa      660

gaagatgaag atgaagaaga agatgatgat gatgaataa                             699


<210> 9
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser 
            20                  25                  30          


Tyr Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His 
        35                  40                  45              


Pro Asp Ala Ala Val Asn Phe Ala Glu Phe Ala Lys Lys Cys Ala Glu 
    50                  55                  60                  


Arg Trp Lys Thr Met Ala Ala Lys Glu Lys Gly Lys Phe Glu Asp Met 
65                  70                  75                  80  


Ala Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile 
                85                  90                  95      


Pro Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro 
            100                 105                 110         


Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro 
        115                 120                 125             


Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys 
    130                 135                 140                 


Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro 
145                 150                 155                 160 


Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile 
                165                 170                 175     


Ala Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val 
            180                 185                 190         


Val Lys Ala Glu Lys Ala Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu 
        195                 200                 205             


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp 
    210                 215                 220                 


Glu Glu Glu Asp Asp Asp Asp Glu 
225                 230         


<210> 10
<211> 162
<212> PRT
<213> Homo sapiens

<400> 10
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 11
<211> 465
<212> DNA
<213> Mus sp.

<400> 11
atgttccatg tttcttttag atatatcttt ggaattcctc cactgatcct tgttctgctg       60

cctgtcacat catctgagtg ccacattaaa gacaaagaag gtaaagcata tgagagtgta      120

ctgatgatca gcatcgatga attggacaaa atgacaggaa ctgatagtaa ttgcccgaat      180

aatgaaccaa acttttttag aaaacatgta tgtgatgata caaaggaagc tgcttttcta      240

aatcgtgctg ctcgcaagtt gaagcaattt cttaaaatga atatcagtga agaattcaat      300

gtccacttac taacagtatc acaaggcaca caaacactgg tgaactgcac aagtaaggaa      360

gaaaaaaacg taaaggaaca gaaaaagaat gatgcatgtt tcctaaagag actactgaga      420

gaaataaaaa cttgttggaa taaaattttg aagggcagta tataa                      465


<210> 12
<211> 534
<212> DNA
<213> Homo sapiens

<400> 12
atgttccatg tttcttttag gtatatcttt ggacttcctc ccctgatcct tgttctgttg       60

ccagtagcat catctgattg tgatattgaa ggtaaagatg gcaaacaata tgagagtgtt      120

ctaatggtca gcatcgatca attattggac agcatgaaag aaattggtag caattgcctg      180

aataatgaat ttaacttttt taaaagacat atctgtgatg ctaataagga aggtatgttt      240

ttattccgtg ctgctcgcaa gttgaggcaa tttcttaaaa tgaatagcac tggtgatttt      300

gatctccact tattaaaagt ttcagaaggc acaacaatac tgttgaactg cactggccag      360

gttaaaggaa gaaaaccagc tgccctgggt gaagcccaac caacaaagag tttggaagaa      420

aataaatctt taaaggaaca gaaaaaactg aatgacttgt gtttcctaaa gagactatta      480

caagagataa aaacttgttg gaataaaatt ttgatgggca ctaaagaaca ctga            534


<210> 13
<211> 154
<212> PRT
<213> Mus sp.

<400> 13
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210> 14
<211> 177
<212> PRT
<213> Homo sapiens

<400> 14
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210> 15
<211> 1059
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atggagggga tcagtatata cacttcagat aactacaccg aggaaatggg ctcaggggac       60

tatgactcca tgaaggaacc ctgtttccgt gaagaaaatg ctaatttcaa taaaatcttc      120

ctgcccacca tctactccat catcttctta actggcattg tgggcaatgg attggtcatc      180

ctggtcatgg gttaccagaa gaaactgaga agcatgacgg acaagtacag gctgcacctg      240

tcagtggccg acctcctctt tgtcatcacg cttcccttct gggcagttga tgccgtggca      300

aactggtact ttgggaactt cctatgcaag gcagtccatg tcatctacac agtcaacctc      360

tacagcagtg tcctcatcct ggccttcatc agtctggacc gctacctggc catcgtccac      420

gccaccaaca gtcagaggcc aaggaagctg ttggctgaaa aggtggtcgc tgttggcgtc      480

tggatccctg ccctcctgct gactattccc gacttcatct ttgccaacgt cagtgaggca      540

gatgacagat atatctgtga ccgcttctac cccaatgact tgtgggtggt tgtgttccag      600

tttcagcaca tcatggttgg ccttatcctg cctggtattg tcatcctgtc ctgctattgc      660

attatcatct ccaagctgtc acactccaag ggccaccaga agcgcaaggc cctcaagacc      720

acagtcatcc tcatcctggc tttcttcgcc tgttggctgc cttactacat tgggatcagc      780

atcgactcct tcatcctcct ggaaatcatc aagcaagggt gtgagtttga gaacactgtg      840

cacaagtgga tttccatcac cgaggcccta gctttcttcc actgttgtct gaaccccatc      900

ctctatgctt tccttggagc caaatttaaa acctctgccc agcacgcact cacctctgtg      960

agcagagggt ccagcctcaa gatcctctcc aaaggaaagc gaggtggaca ttcatctgtt     1020

tccactgagt ctgagtcttc aagttttcac tccagctaa                            1059


<210> 16
<211> 1080
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atggaaccga tcagtgtgag tatatacact tctgataact actctgaaga agtgggttct       60

ggagactatg actccaacaa ggaaccctgc ttccgggatg aaaacgtcca tttcaatagg      120

atcttcctgc ccaccatcta cttcatcatc ttcttgactg gcatagtcgg caatggattg      180

gtgatcctgg tcatgggtta ccagaagaag ctaaggagca tgacggacaa gtaccggctg      240

cacctgtcag tggctgacct cctctttgtc atcacactcc ccttctgggc agttgatgcc      300

atggctgact ggtactttgg gaaatttttg tgtaaggctg tccatatcat ctacactgtc      360

aacctctaca gcagcgttct catcctggcc ttcatcagcc tggaccgata cctcgctatt      420

gtccacgcca ccaacagtca gaggccaagg aaactgctgg ctgaaaaggc agtcgctgtg      480

ggcgtctgga tcccagccct cctcctgact atacctgact tcatctttgc cgacgtcagc      540

cagggggaca tcagtcaggg ggatgacagg tacatctgtg accgccttta ccccgatagc      600

ctgtggatgg tggtgtttca attccagcat ataatggtgg gtctcgtcct gcccggcatc      660

gtcatcctct cctgttactg catcatcatc tctaagctgt cacactccaa gggccaccag      720

aagcgcaagg ccctcaagac gacagtcatc ctcatcctag ctttctttgc ctgctggctg      780

ccatattatg tggggatcag catcgactcc ttcatccttt tgggggtcat caagcaagga      840

tgtgacttcg agagcatcgt gcacaagtgg atctccatca cagaggccct cgccttcttc      900

cactgttgcc tgaaccccat cctctatgcc ttcctcgggg ccaagttcaa aagctctgcc      960

cagcatgcac tcaactccat gagcagaggc tccagcctca agatcctttc caaaggaaag     1020

cggggtggac actcttccgt ctccacggag tcagaatcct ccagttttca ctccagctaa     1080


<210> 17
<211> 1059
<212> DNA
<213> Homo sapiens

<400> 17
atggagggga tcagtatata cacttcagat aactacaccg aggaaatggg ctcaggggac       60

tatgactcca tgaaggaacc ctgtttccgt gaagaaaatg ctaatttcaa taaaatcttc      120

ctgcccacca tctactccat catcttctta actggcattg tgggcaatgg attggtcatc      180

ctggtcatgg gttaccagaa gaaactgaga agcatgacgg acaagtacag gctgcacctg      240

tcagtggccg acctcctctt tgtcatcacg cttcccttct gggcagttga tgccgtggca      300

aactggtact ttgggaactt cctatgcaag gcagtccatg tcatctacac agtcaacctc      360

tacagcagtg tcctcatcct ggccttcatc agtctggacc gctacctggc catcgtccac      420

gccaccaaca gtcagaggcc aaggaagctg ttggctgaaa aggtggtcta tgttggcgtc      480

tggatccctg ccctcctgct gactattccc gacttcatct ttgccaacgt cagtgaggca      540

gatgacagat atatctgtga ccgcttctac cccaatgact tgtgggtggt tgtgttccag      600

tttcagcaca tcatggttgg ccttatcctg cctggtattg tcatcctgtc ctgctattgc      660

attatcatct ccaagctgtc acactccaag ggccaccaga agcgcaaggc cctcaagacc      720

acagtcatcc tcatcctggc tttcttcgcc tgttggctgc cttactacat tgggatcagc      780

atcgactcct tcatcctcct ggaaatcatc aagcaagggt gtgagtttga gaacactgtg      840

cacaagtgga tttccatcac cgaggcccta gctttcttcc actgttgtct gaaccccatc      900

ctctatgctt tccttggagc caaatttaaa acctctgccc agcacgcact cacctctgtg      960

agcagagggt ccagcctcaa gatcctctcc aaaggaaagc gaggtggaca ttcatctgtt     1020

tccactgagt ctgagtcttc aagttttcac tccagctaa                            1059


<210> 18
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Ala Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 19
<211> 359
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Glu Pro Ile Ser Val Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu 
1               5                   10                  15      


Glu Val Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg 
            20                  25                  30          


Asp Glu Asn Val His Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe 
        35                  40                  45              


Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val 
    50                  55                  60                  


Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu 
65                  70                  75                  80  


His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp 
                85                  90                  95      


Ala Val Asp Ala Met Ala Asp Trp Tyr Phe Gly Lys Phe Leu Cys Lys 
            100                 105                 110         


Ala Val His Ile Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile 
        115                 120                 125             


Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr 
    130                 135                 140                 


Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Ala Val Ala Val 
145                 150                 155                 160 


Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe 
                165                 170                 175     


Ala Asp Val Ser Gln Gly Asp Ile Ser Gln Gly Asp Asp Arg Tyr Ile 
            180                 185                 190         


Cys Asp Arg Leu Tyr Pro Asp Ser Leu Trp Met Val Val Phe Gln Phe 
        195                 200                 205             


Gln His Ile Met Val Gly Leu Val Leu Pro Gly Ile Val Ile Leu Ser 
    210                 215                 220                 


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
225                 230                 235                 240 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
                245                 250                 255     


Ala Cys Trp Leu Pro Tyr Tyr Val Gly Ile Ser Ile Asp Ser Phe Ile 
            260                 265                 270         


Leu Leu Gly Val Ile Lys Gln Gly Cys Asp Phe Glu Ser Ile Val His 
        275                 280                 285             


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
    290                 295                 300                 


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Ser Ser Ala 
305                 310                 315                 320 


Gln His Ala Leu Asn Ser Met Ser Arg Gly Ser Ser Leu Lys Ile Leu 
                325                 330                 335     


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
            340                 345                 350         


Ser Ser Ser Phe His Ser Ser 
        355                 


<210> 20
<211> 352
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210> 21
<211> 1125
<212> DNA
<213> Homo sapiens

<400> 21
atgctgtcca catctcgttc tcggtttatc agaaatacca acgagagcgg tgaagaagtc       60

accacctttt ttgattatga ttacggtgct ccctgtcata aatttgacgt gaagcaaatt      120

ggggcccaac tcctgcctcc gctctactcg ctggtgttca tctttggttt tgtgggcaac      180

atgctggtcg tcctcatctt aataaactgc aaaaagctga agtgcttgac tgacatttac      240

ctgctcaacc tggccatctc tgatctgctt tttcttatta ctctcccatt gtgggctcac      300

tctgctgcaa atgagtgggt ctttgggaat gcaatgtgca aattattcac agggctgtat      360

cacatcggtt attttggcgg aatcttcttc atcatcctcc tgacaatcga tagatacctg      420

gctattgtcc atgctgtgtt tgctttaaaa gccaggacgg tcacctttgg ggtggtgaca      480

agtgtgatca cctggttggt ggctgtgttt gcttctgtcc caggaatcat ctttactaaa      540

tgccagaaag aagattctgt ttatgtctgt ggcccttatt ttccacgagg atggaataat      600

ttccacacaa taatgaggaa cattttgggg ctggtcctgc cgctgctcat catggtcatc      660

tgctactcgg gaatcctgaa aaccctgctt cggtgtcgaa acgagaagaa gaggcatagg      720

gcagtgagag tcatcttcac catcatgatt gtttactttc tcttctggac tccctataat      780

attgtcattc tcctgaacac cttccaggaa ttcttcggcc tgagtaactg tgaaagcacc      840

agtcaactgg accaagccac gcaggtgaca gagactcttg ggatgactca ctgctgcatc      900

aatcccatca tctatgcctt cgttggggag aagttcagaa gcctttttca catagctctt      960

ggctgtagga ttgccccact ccaaaaacca gtgtgtggag gtccaggagt gagaccagga     1020

aagaatgtga aagtgactac acaaggactc ctcgatggtc gtggaaaagg aaagtcaatt     1080

ggcagagccc ctgaagccag tcttcaggac aaagaaggag cctag                     1125


<210> 22
<211> 1122
<212> DNA
<213> Mus sp.

<400> 22
atggaagaca ataatatgtt acctcagttc atccacggca tactatcaac atctcattct       60

ctatttacac gaagtatcca agagcttgat gaaggggcca ccacaccgta tgactacgat      120

gatggtgagc cttgtcataa aaccagtgtg aagcaaattg gagcttggat cctgcctcca      180

ctctactccc tggtattcat ctttggtttt gtgggcaaca tgttggtcat tataattctg      240

ataggctgta aaaagctgaa gagcatgact gatatctatc tgctcaactt ggccatctct      300

gacctgctct tcctgctcac attaccattc tgggctcact atgctgcaaa tgagtgggtc      360

tttgggaata taatgtgtaa agtattcaca gggctctatc acattggtta ttttggtgga      420

atctttttca ttatcctcct gacaattgat aggtacttgg ctattgttca tgctgtgttt      480

gctttaaaag ccaggacagt tacctttggg gtgataacaa gtgtagtcac ttgggtggtg      540

gctgtgtttg cctctctacc aggaatcata tttactaaat ccaaacaaga tgatcaccat      600

tacacctgtg gcccttattt tacacaacta tggaagaatt tccaaacaat aatgagaaat      660

atcttgagcc tgatcctgcc tctacttgtc atggtcatct gctactcagg aattctccac      720

accctgtttc gctgtaggaa tgagaagaag aggcacaggg ctgtgaggct catctttgcc      780

atcatgattg tctactttct cttctggact ccatacaata ttgttctctt cttgaccacc      840

ttccaggaat ccttgggaat gagtaactgt gtgattgaca agcacttaga ccaggccatg      900

caggtgacag agactcttgg aatgacacac tgctgcatta atcctgtcat ttatgccttt      960

gttggagaga agttccgaag gtatctctcc atatttttca gaaagcacat tgctaaacgt     1020

ctctgcaaac agtgcccagt tttctatagg gagacagcag atcgagtaag ctctacattc     1080

actccttcca ctggggagca agaggtctcg gttgggttgt aa                        1122


<210> 23
<211> 374
<212> PRT
<213> Homo sapiens

<400> 23
Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210> 24
<211> 373
<212> PRT
<213> Mus sp.

<400> 24
Met Glu Asp Asn Asn Met Leu Pro Gln Phe Ile His Gly Ile Leu Ser 
1               5                   10                  15      


Thr Ser His Ser Leu Phe Thr Arg Ser Ile Gln Glu Leu Asp Glu Gly 
            20                  25                  30          


Ala Thr Thr Pro Tyr Asp Tyr Asp Asp Gly Glu Pro Cys His Lys Thr 
        35                  40                  45              


Ser Val Lys Gln Ile Gly Ala Trp Ile Leu Pro Pro Leu Tyr Ser Leu 
    50                  55                  60                  


Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Ile Ile Ile Leu 
65                  70                  75                  80  


Ile Gly Cys Lys Lys Leu Lys Ser Met Thr Asp Ile Tyr Leu Leu Asn 
                85                  90                  95      


Leu Ala Ile Ser Asp Leu Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala 
            100                 105                 110         


His Tyr Ala Ala Asn Glu Trp Val Phe Gly Asn Ile Met Cys Lys Val 
        115                 120                 125             


Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile Phe Phe Ile 
    130                 135                 140                 


Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
145                 150                 155                 160 


Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Val Val 
                165                 170                 175     


Thr Trp Val Val Ala Val Phe Ala Ser Leu Pro Gly Ile Ile Phe Thr 
            180                 185                 190         


Lys Ser Lys Gln Asp Asp His His Tyr Thr Cys Gly Pro Tyr Phe Thr 
        195                 200                 205             


Gln Leu Trp Lys Asn Phe Gln Thr Ile Met Arg Asn Ile Leu Ser Leu 
    210                 215                 220                 


Ile Leu Pro Leu Leu Val Met Val Ile Cys Tyr Ser Gly Ile Leu His 
225                 230                 235                 240 


Thr Leu Phe Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg 
                245                 250                 255     


Leu Ile Phe Ala Ile Met Ile Val Tyr Phe Leu Phe Trp Thr Pro Tyr 
            260                 265                 270         


Asn Ile Val Leu Phe Leu Thr Thr Phe Gln Glu Ser Leu Gly Met Ser 
        275                 280                 285             


Asn Cys Val Ile Asp Lys His Leu Asp Gln Ala Met Gln Val Thr Glu 
    290                 295                 300                 


Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Val Ile Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Ile Phe Phe Arg Lys His 
                325                 330                 335     


Ile Ala Lys Arg Leu Cys Lys Gln Cys Pro Val Phe Tyr Arg Glu Thr 
            340                 345                 350         


Ala Asp Arg Val Ser Ser Thr Phe Thr Pro Ser Thr Gly Glu Gln Glu 
        355                 360                 365             


Val Ser Val Gly Leu 
    370             


<210> 25
<211> 1530
<212> DNA
<213> Homo sapiens

<400> 25
atgggagtgc taaaattcaa gcacatcttt ttcagaagct ttgttaaatc aagtggagta       60

tcccagatag ttttcacctt ccttctgatt ccatgttgct tgactctgaa tttcagagca      120

cctcctgtta ttccaaatgt gcctttcctc tgggcctgga atgccccaag tgaattttgt      180

cttggaaaat ttgatgagcc actagatatg agcctcttct ctttcatagg aagcccccga      240

ataaacgcca ccgggcaagg tgttacaata ttttatgttg atagacttgg ctactatcct      300

tacatagatt caatcacagg agtaactgtg aatggaggaa tcccccagaa gatttcctta      360

caagaccatc tggacaaagc taagaaagac attacatttt atatgccagt agacaatttg      420

ggaatggctg ttattgactg ggaagaatgg agacccactt gggcaagaaa ctggaaacct      480

aaagatgttt acaagaatag gtctattgaa ttggttcagc aacaaaatgt acaacttagt      540

ctcacagagg ccactgagaa agcaaaacaa gaatttgaaa aggcagggaa ggatttcctg      600

gtagagacta taaaattggg aaaattactt cggccaaatc acttgtgggg ttattatctt      660

tttccggatt gttacaacca tcactataag aaacccggtt acaatggaag ttgcttcaat      720

gtagaaataa aaagaaatga tgatctcagc tggttgtgga atgaaagcac tgctctttac      780

ccatccattt atttgaacac tcagcagtct cctgtagctg ctacactcta tgtgcgcaat      840

cgagttcggg aagccatcag agtttccaaa atacctgatg caaaaagtcc acttccggtt      900

tttgcatata cccgcatagt ttttactgat caagttttga aattcctttc tcaagatgaa      960

cttgtgtata catttggcga aactgttgct ctgggtgctt ctggaattgt aatatgggga     1020

accctcagta taatgcgaag tatgaaatct tgcttgctcc tagacaatta catggagact     1080

atactgaatc cttacataat caacgtcaca ctagcagcca aaatgtgtag ccaagtgctt     1140

tgccaggagc aaggagtgtg tataaggaaa aactggaatt caagtgacta tcttcacctc     1200

aacccagata attttgctat tcaacttgag aaaggtggaa agttcacagt acgtggaaaa     1260

ccgacacttg aagacctgga gcaattttct gaaaaatttt attgcagctg ttatagcacc     1320

ttgagttgta aggagaaagc tgatgtaaaa gacactgatg ctgttgatgt gtgtattgct     1380

gatggtgtct gtatagatgc ttttctaaaa cctcccatgg agacagaaga acctcaaatt     1440

ttctacaatg cttcaccctc cacactatct gccacaatgt tcattgttag tattttgttt     1500

cttatcattt cttctgtagc gagtttgtaa                                      1530


<210> 26
<211> 509
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys 
1               5                   10                  15      


Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys 
            20                  25                  30          


Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro 
        35                  40                  45              


Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe 
    50                  55                  60                  


Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg 
65                  70                  75                  80  


Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu 
                85                  90                  95      


Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly 
            100                 105                 110         


Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys 
        115                 120                 125             


Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val 
    130                 135                 140                 


Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro 
145                 150                 155                 160 


Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn 
                165                 170                 175     


Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe 
            180                 185                 190         


Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys 
        195                 200                 205             


Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys 
    210                 215                 220                 


Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn 
225                 230                 235                 240 


Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser 
                245                 250                 255     


Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val 
            260                 265                 270         


Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val 
        275                 280                 285             


Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr 
    290                 295                 300                 


Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu 
305                 310                 315                 320 


Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile 
                325                 330                 335     


Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu 
            340                 345                 350         


Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn 
        355                 360                 365             


Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln 
    370                 375                 380                 


Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu 
385                 390                 395                 400 


Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr 
                405                 410                 415     


Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys 
            420                 425                 430         


Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp 
        435                 440                 445             


Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys 
    450                 455                 460                 


Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile 
465                 470                 475                 480 


Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val 
                485                 490                 495     


Ser Ile Leu Phe Leu Ile Ile Ser Ser Val Ala Ser Leu 
            500                 505                 


<210> 27
<211> 2398
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Hyaluronidase sequence

<400> 27
ccgcgatacg aatgttcaaa cgccagatta tgaaaagttg aggaacacat ggctgaacgt       60

taactacggt tatgatcagt atgatgagaa gaatgacgca atgaagaaga agtttgatgc      120

tacggagaaa gaggcagaga aattactcag tagcatgaaa actgaaagtg gaaggactta      180

cttgtgggat agtgcaaaag atttagataa caagtctgcg gatatgactc gtacctatcg      240

taatattgag aaaatcgcag aagcgatgaa gcataaagat actaagttaa atactccgga      300

taataaaaac aaagttaaag atgcccttga gtggctgcat aaaaatgcct atggaaaaga      360

accggtgaaa aaacttgaag aactaaaaac aaatttctca aaatcagcac ctcaaaagaa      420

tacaaactta aattggtggg attatgaaat tggaacacct agagcactaa caaataccct      480

tatactctta aaagaagatt ttactgatga agaaaagaaa aaatacactg cccctattaa      540

aactttcgcc ccaaaaagtg atgaaatatt atcttctgta ggaaaagctg aacctgctaa      600

aggcggaaat ttagtagaca tttctaaagt aaaactttta gaaagtatta tcgaagaaga      660

tgcaactatg atgaaagaat caatagaggc atttaataaa gtcttcactt acgttcaaag      720

taatgcaact ggtaaagaac gtaatggatt ctataaagac ggctcttata ttgatcatca      780

agacgtccca tacactggtg cttatggcgt tgtactctta gaggggattt ctcaaatgat      840

gccgatgata aaagaaacac cttttaaaga tagtaatcaa aatgatacaa cattaaagtc      900

gtggattgat gaaggattta tgccactcat ttataaaggt gaaatgatgg atttatcacg      960

tggtagagcc attagccgtg aaaatgaaac gagtcactca acatctgcaa ctgtaatgaa     1020

atcattgttg agattaagtg atgccatgga tgagtcaaca aaagctaaat ataagcaaat     1080

cgttaaaact tctgttaaat ctgattcaag ttataaacaa aacgattatt taagctctta     1140

ttcagatata agcaaaatga agtctttaat tgaagacagc actatttcta ctaacggttt     1200

aacacaacaa cttaaaatat ataatgacat gaatcgtgtc acctatcata acaaagactt     1260

agactttgca tttggcttaa gtatgacgtc gaaaaacgtc gcacattacg aaagtatcaa     1320

cggagagaac ttaaaaggtt ggcacactgg tgctggaatg tcttatttat acaatagcga     1380

tgtgaaacac taccgtgata acttctgggc gacagctgat atgaaacgtt tagcaggtac     1440

tacaacttta gataatgaag aacctaaaga aaataagaac tccgataaaa cttttgtagg     1500

cggaacaaaa ttcgatgacc aacatgctag tatcggaatg gattttgaaa atcaggacaa     1560

aactttaact gccaaaaaat catatttcat attaaacgat aaaattgtct tcttaggaac     1620

tggcattaaa agtactgatt catcaaagaa tccagtgaca acgattgaaa atcgcaaatc     1680

gaatgggtat acgttattta cagacgataa acaaacaacc gcttcaaata ttaatgatca     1740

ggaaaccaat tcagtctttt tagagtccac agatacaaaa aagaacatcg gttatcattt     1800

tttaaacgaa tcgaaaataa ctgtaaaaaa agaaagtcat actggtaagt ggagtgatat     1860

aaataaaagt caaaagtcag atgacaaaac tgatgagtat tatgaagtaa ctcaaaagca     1920

ttctaataca gatgataaat atgcatatgt cttgtatcca ggcttatcta aagataattt     1980

taaatccaaa gcaagccaag taactatcgt taaacaagat gatgacttcc acattgtgaa     2040

agataatgaa tcggtttggg ctggtgtcaa ttatagtaat agcactcaaa cttttgacat     2100

taacaacacc aaggttgagg ttaaagcgaa agggatgttc attttgaaaa acaaggacga     2160

taatacgtac gaatgctcat tctataatcc tgagtctacg aatacggctt cagacataga     2220

aagtaagatc agtatgacgg gatactcaat cacgaataaa aacacaagta cgtccaacga     2280

aagtggtgtg catttcgagt tgactaaata tgctgccgcg atgtctggag caggtccgtg     2340

ggcagcctgg ccattcctac tctcactggc gctcatgcta ctatggctgc tctcatga       2398


<210> 28
<211> 799
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Hyaluronidase sequence

<400> 28
Gly Arg Asp Thr Asn Val Gln Thr Pro Asp Tyr Glu Lys Leu Arg Asn 
1               5                   10                  15      


Thr Trp Leu Asn Val Asn Tyr Gly Tyr Asp Gln Tyr Asp Glu Lys Asn 
            20                  25                  30          


Asp Ala Met Lys Lys Lys Phe Asp Ala Thr Glu Lys Glu Ala Glu Lys 
        35                  40                  45              


Leu Leu Ser Ser Met Lys Thr Glu Ser Gly Arg Thr Tyr Leu Trp Asp 
    50                  55                  60                  


Ser Ala Lys Asp Leu Asp Asn Lys Ser Ala Asp Met Thr Arg Thr Tyr 
65                  70                  75                  80  


Arg Asn Ile Glu Lys Ile Ala Glu Ala Met Lys His Lys Asp Thr Lys 
                85                  90                  95      


Leu Asn Thr Pro Asp Asn Lys Asn Lys Val Lys Asp Ala Leu Glu Trp 
            100                 105                 110         


Leu His Lys Asn Ala Tyr Gly Lys Glu Pro Val Lys Lys Leu Glu Glu 
        115                 120                 125             


Leu Lys Thr Asn Phe Ser Lys Ser Ala Pro Gln Lys Asn Thr Asn Leu 
    130                 135                 140                 


Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Leu Thr Asn Thr 
145                 150                 155                 160 


Leu Ile Leu Leu Lys Glu Asp Phe Thr Asp Glu Glu Lys Lys Lys Tyr 
                165                 170                 175     


Thr Ala Pro Ile Lys Thr Phe Ala Pro Lys Ser Asp Glu Ile Leu Ser 
            180                 185                 190         


Ser Val Gly Lys Ala Glu Pro Ala Lys Gly Gly Asn Leu Val Asp Ile 
        195                 200                 205             


Ser Lys Val Lys Leu Leu Glu Ser Ile Ile Glu Glu Asp Ala Thr Met 
    210                 215                 220                 


Met Lys Glu Ser Ile Glu Ala Phe Asn Lys Val Phe Thr Tyr Val Gln 
225                 230                 235                 240 


Ser Asn Ala Thr Gly Lys Glu Arg Asn Gly Phe Tyr Lys Asp Gly Ser 
                245                 250                 255     


Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly Ala Tyr Gly Val Val 
            260                 265                 270         


Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met Ile Lys Glu Thr Pro 
        275                 280                 285             


Phe Lys Asp Ser Asn Gln Asn Asp Thr Thr Leu Lys Ser Trp Ile Asp 
    290                 295                 300                 


Glu Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu Met Met Asp Leu Ser 
305                 310                 315                 320 


Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr Ser His Ser Thr Ser 
                325                 330                 335     


Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser Asp Ala Met Asp Glu 
            340                 345                 350         


Ser Thr Lys Ala Lys Tyr Lys Gln Ile Val Lys Thr Ser Val Lys Ser 
        355                 360                 365             


Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Ser Ser Tyr Ser Asp Ile 
    370                 375                 380                 


Ser Lys Met Lys Ser Leu Ile Glu Asp Ser Thr Ile Ser Thr Asn Gly 
385                 390                 395                 400 


Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met Asn Arg Val Thr Tyr 
                405                 410                 415     


His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu Ser Met Thr Ser Lys 
            420                 425                 430         


Asn Val Ala His Tyr Glu Ser Ile Asn Gly Glu Asn Leu Lys Gly Trp 
        435                 440                 445             


His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn Ser Asp Val Lys His 
    450                 455                 460                 


Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp Met Lys Arg Leu Ala Gly 
465                 470                 475                 480 


Thr Thr Thr Leu Asp Asn Glu Glu Pro Lys Glu Asn Lys Asn Ser Asp 
                485                 490                 495     


Lys Thr Phe Val Gly Gly Thr Lys Phe Asp Asp Gln His Ala Ser Ile 
            500                 505                 510         


Gly Met Asp Phe Glu Asn Gln Asp Lys Thr Leu Thr Ala Lys Lys Ser 
        515                 520                 525             


Tyr Phe Ile Leu Asn Asp Lys Ile Val Phe Leu Gly Thr Gly Ile Lys 
    530                 535                 540                 


Ser Thr Asp Ser Ser Lys Asn Pro Val Thr Thr Ile Glu Asn Arg Lys 
545                 550                 555                 560 


Ser Asn Gly Tyr Thr Leu Phe Thr Asp Asp Lys Gln Thr Thr Ala Ser 
                565                 570                 575     


Asn Ile Asn Asp Gln Glu Thr Asn Ser Val Phe Leu Glu Ser Thr Asp 
            580                 585                 590         


Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn Glu Ser Lys Ile Thr 
        595                 600                 605             


Val Lys Lys Glu Ser His Thr Gly Lys Trp Ser Asp Ile Asn Lys Ser 
    610                 615                 620                 


Gln Lys Ser Asp Asp Lys Thr Asp Glu Tyr Tyr Glu Val Thr Gln Lys 
625                 630                 635                 640 


His Ser Asn Thr Asp Asp Lys Tyr Ala Tyr Val Leu Tyr Pro Gly Leu 
                645                 650                 655     


Ser Lys Asp Asn Phe Lys Ser Lys Ala Ser Gln Val Thr Ile Val Lys 
            660                 665                 670         


Gln Asp Asp Asp Phe His Ile Val Lys Asp Asn Glu Ser Val Trp Ala 
        675                 680                 685             


Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe Asp Ile Asn Asn Thr 
    690                 695                 700                 


Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile Leu Lys Asn Lys Asp 
705                 710                 715                 720 


Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro Glu Ser Thr Asn Thr 
                725                 730                 735     


Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr Gly Tyr Ser Ile Thr 
            740                 745                 750         


Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly Val His Phe Glu Leu 
        755                 760                 765             


Thr Lys Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala Ala Trp 
    770                 775                 780                 


Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser 
785                 790                 795                 


<210> 29
<211> 2454
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
atggactgga catggattct ctttctagtg gccgcagcca caagggtcca cagcggccgc       60

gatacgaatg ttcaaacgcc agattatgaa aagttgagga acacatggct gaacgttaac      120

tacggttatg atcagtatga tgagaagaat gacgcaatga agaagaagtt tgatgctacg      180

gagaaagagg cagagaaatt actcagtagc atgaaaactg aaagtggaag gacttacttg      240

tgggatagtg caaaagattt agataacaag tctgcggata tgactcgtac ctatcgtaat      300

attgagaaaa tcgcagaagc gatgaagcat aaagatacta agttaaatac tccggataat      360

aaaaacaaag ttaaagatgc ccttgagtgg ctgcataaaa atgcctatgg aaaagaaccg      420

gtgaaaaaac ttgaagaact aaaaacaaat ttctcaaaat cagcacctca aaagaataca      480

aacttaaatt ggtgggatta tgaaattgga acacctagag cactaacaaa tacccttata      540

ctcttaaaag aagattttac tgatgaagaa aagaaaaaat acactgcccc tattaaaact      600

ttcgccccaa aaagtgatga aatattatct tctgtaggaa aagctgaacc tgctaaaggc      660

ggaaatttag tagacatttc taaagtaaaa cttttagaaa gtattatcga agaagatgca      720

actatgatga aagaatcaat agaggcattt aataaagtct tcacttacgt tcaaagtaat      780

gcaactggta aagaacgtaa tggattctat aaagacggct cttatattga tcatcaagac      840

gtcccataca ctggtgctta tggcgttgta ctcttagagg ggatttctca aatgatgccg      900

atgataaaag aaacaccttt taaagatagt aatcaaaatg atacaacatt aaagtcgtgg      960

attgatgaag gatttatgcc actcatttat aaaggtgaaa tgatggattt atcacgtggt     1020

agagccatta gccgtgaaaa tgaaacgagt cactcaacat ctgcaactgt aatgaaatca     1080

ttgttgagat taagtgatgc catggatgag tcaacaaaag ctaaatataa gcaaatcgtt     1140

aaaacttctg ttaaatctga ttcaagttat aaacaaaacg attatttaag ctcttattca     1200

gatataagca aaatgaagtc tttaattgaa gacagcacta tttctactaa cggtttaaca     1260

caacaactta aaatatataa tgacatgaat cgtgtcacct atcataacaa agacttagac     1320

tttgcatttg gcttaagtat gacgtcgaaa aacgtcgcac attacgaaag tatcaacgga     1380

gagaacttaa aaggttggca cactggtgct ggaatgtctt atttatacaa tagcgatgtg     1440

aaacactacc gtgataactt ctgggcgaca gctgatatga aacgtttagc aggtactaca     1500

actttagata atgaagaacc taaagaaaat aagaactccg ataaaacttt tgtaggcgga     1560

acaaaattcg atgaccaaca tgctagtatc ggaatggatt ttgaaaatca ggacaaaact     1620

ttaactgcca aaaaatcata tttcatatta aacgataaaa ttgtcttctt aggaactggc     1680

attaaaagta ctgattcatc aaagaatcca gtgacaacga ttgaaaatcg caaatcgaat     1740

gggtatacgt tatttacaga cgataaacaa acaaccgctt caaatattaa tgatcaggaa     1800

accaattcag tctttttaga gtccacagat acaaaaaaga acatcggtta tcatttttta     1860

aacgaatcga aaataactgt aaaaaaagaa agtcatactg gtaagtggag tgatataaat     1920

aaaagtcaaa agtcagatga caaaactgat gagtattatg aagtaactca aaagcattct     1980

aatacagatg ataaatatgc atatgtcttg tatccaggct tatctaaaga taattttaaa     2040

tccaaagcaa gccaagtaac tatcgttaaa caagatgatg acttccacat tgtgaaagat     2100

aatgaatcgg tttgggctgg tgtcaattat agtaatagca ctcaaacttt tgacattaac     2160

aacaccaagg ttgaggttaa agcgaaaggg atgttcattt tgaaaaacaa ggacgataat     2220

acgtacgaat gctcattcta taatcctgag tctacgaata cggcttcaga catagaaagt     2280

aagatcagta tgacgggata ctcaatcacg aataaaaaca caagtacgtc caacgaaagt     2340

ggtgtgcatt tcgagttgac taaatatgct gccgcgatgt ctggagcagg tccgtgggca     2400

gcctggccat tcctactctc actggcgctc atgctactat ggctgctctc atga           2454


<210> 30
<211> 817
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Arg Asp Thr Asn Val Gln Thr Pro Asp Tyr Glu Lys Leu 
            20                  25                  30          


Arg Asn Thr Trp Leu Asn Val Asn Tyr Gly Tyr Asp Gln Tyr Asp Glu 
        35                  40                  45              


Lys Asn Asp Ala Met Lys Lys Lys Phe Asp Ala Thr Glu Lys Glu Ala 
    50                  55                  60                  


Glu Lys Leu Leu Ser Ser Met Lys Thr Glu Ser Gly Arg Thr Tyr Leu 
65                  70                  75                  80  


Trp Asp Ser Ala Lys Asp Leu Asp Asn Lys Ser Ala Asp Met Thr Arg 
                85                  90                  95      


Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met Lys His Lys Asp 
            100                 105                 110         


Thr Lys Leu Asn Thr Pro Asp Asn Lys Asn Lys Val Lys Asp Ala Leu 
        115                 120                 125             


Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro Val Lys Lys Leu 
    130                 135                 140                 


Glu Glu Leu Lys Thr Asn Phe Ser Lys Ser Ala Pro Gln Lys Asn Thr 
145                 150                 155                 160 


Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Leu Thr 
                165                 170                 175     


Asn Thr Leu Ile Leu Leu Lys Glu Asp Phe Thr Asp Glu Glu Lys Lys 
            180                 185                 190         


Lys Tyr Thr Ala Pro Ile Lys Thr Phe Ala Pro Lys Ser Asp Glu Ile 
        195                 200                 205             


Leu Ser Ser Val Gly Lys Ala Glu Pro Ala Lys Gly Gly Asn Leu Val 
    210                 215                 220                 


Asp Ile Ser Lys Val Lys Leu Leu Glu Ser Ile Ile Glu Glu Asp Ala 
225                 230                 235                 240 


Thr Met Met Lys Glu Ser Ile Glu Ala Phe Asn Lys Val Phe Thr Tyr 
                245                 250                 255     


Val Gln Ser Asn Ala Thr Gly Lys Glu Arg Asn Gly Phe Tyr Lys Asp 
            260                 265                 270         


Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly Ala Tyr Gly 
        275                 280                 285             


Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met Ile Lys Glu 
    290                 295                 300                 


Thr Pro Phe Lys Asp Ser Asn Gln Asn Asp Thr Thr Leu Lys Ser Trp 
305                 310                 315                 320 


Ile Asp Glu Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu Met Met Asp 
                325                 330                 335     


Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr Ser His Ser 
            340                 345                 350         


Thr Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser Asp Ala Met 
        355                 360                 365             


Asp Glu Ser Thr Lys Ala Lys Tyr Lys Gln Ile Val Lys Thr Ser Val 
    370                 375                 380                 


Lys Ser Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Ser Ser Tyr Ser 
385                 390                 395                 400 


Asp Ile Ser Lys Met Lys Ser Leu Ile Glu Asp Ser Thr Ile Ser Thr 
                405                 410                 415     


Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met Asn Arg Val 
            420                 425                 430         


Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu Ser Met Thr 
        435                 440                 445             


Ser Lys Asn Val Ala His Tyr Glu Ser Ile Asn Gly Glu Asn Leu Lys 
    450                 455                 460                 


Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn Ser Asp Val 
465                 470                 475                 480 


Lys His Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp Met Lys Arg Leu 
                485                 490                 495     


Ala Gly Thr Thr Thr Leu Asp Asn Glu Glu Pro Lys Glu Asn Lys Asn 
            500                 505                 510         


Ser Asp Lys Thr Phe Val Gly Gly Thr Lys Phe Asp Asp Gln His Ala 
        515                 520                 525             


Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys Thr Leu Thr Ala Lys 
    530                 535                 540                 


Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val Phe Leu Gly Thr Gly 
545                 550                 555                 560 


Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val Thr Thr Ile Glu Asn 
                565                 570                 575     


Arg Lys Ser Asn Gly Tyr Thr Leu Phe Thr Asp Asp Lys Gln Thr Thr 
            580                 585                 590         


Ala Ser Asn Ile Asn Asp Gln Glu Thr Asn Ser Val Phe Leu Glu Ser 
        595                 600                 605             


Thr Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn Glu Ser Lys 
    610                 615                 620                 


Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Ser Asp Ile Asn 
625                 630                 635                 640 


Lys Ser Gln Lys Ser Asp Asp Lys Thr Asp Glu Tyr Tyr Glu Val Thr 
                645                 650                 655     


Gln Lys His Ser Asn Thr Asp Asp Lys Tyr Ala Tyr Val Leu Tyr Pro 
            660                 665                 670         


Gly Leu Ser Lys Asp Asn Phe Lys Ser Lys Ala Ser Gln Val Thr Ile 
        675                 680                 685             


Val Lys Gln Asp Asp Asp Phe His Ile Val Lys Asp Asn Glu Ser Val 
    690                 695                 700                 


Trp Ala Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe Asp Ile Asn 
705                 710                 715                 720 


Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile Leu Lys Asn 
                725                 730                 735     


Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro Glu Ser Thr 
            740                 745                 750         


Asn Thr Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr Gly Tyr Ser 
        755                 760                 765             


Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly Val His Phe 
    770                 775                 780                 


Glu Leu Thr Lys Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
785                 790                 795                 800 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                805                 810                 815     


Ser 
    


<210> 31
<211> 418
<212> DNA
<213> Mus sp.

<400> 31
aattctatgg ctccgacttc aagttctacc aagaagaccc agcttcaatt agaacattta       60

cttctagatt tacaaatgat tctgaatggt atcaacaatt ataagaatcc aaagcttact      120

cgtatgttga cctttaaatt ctatatgcct aagaaggcta ctgaattaaa acacctgcag      180

tgtttagaag aagagctcaa accgttagaa gaagttctga atctggctca atctaaaaac      240

ttccatttac gtccacgaga tcttatctct aatattaacg taatcgtttt ggaacttaaa      300

ggatccgaaa ctaccttcat gtgtgaatat gctgacgaaa ccgctacgat cgtagaattt      360

cttaatcgat ggattacttt ctgtcaatct attatctcta ccttaacttg agtcgacg        418


<210> 32
<211> 462
<212> DNA
<213> Homo sapiens

<400> 32
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210> 33
<211> 169
<212> PRT
<213> Mus sp.

<400> 33
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210> 34
<211> 153
<212> PRT
<213> Homo sapiens

<400> 34
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 35
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210> 36
<211> 834
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
atgccagggc tccctgctgg ggagctgtac gggtgggcag tagagacgac ccccagcccc       60

gggccccagc ccgcggcact aacgacaggc gaggccgcgg ccccagagtc cccgcaccag      120

gcagagccgt acctgtcacc ctccccaagc gcctgcaccg cggtgcaaga gcccagccca      180

ggggcgctgg acgtgaccat catgtacaag ggccgcacgg tgctgcagaa ggtggtggga      240

cacccgagct gcacgttcct atacggcccc ccagacccag ctgtccgggc cacagacccc      300

cagcaggtag cattccccag ccctgccgag ctaccggacc agaagcagct gcgctacacg      360

gaggaactgc tgcggcacgt ggcccctggg ttgcacctgg agcttcgggg gccacagctg      420

tgggcccggc gcatgggcaa gtgcaaggtg tactgggagg tgggcggacc cccaggctcc      480

gccagcccct ccaccccagc ctgcctgctg cctcggaact gtgacacccc catcttcgac      540

ttcagagtct tcttccaaga gctggtggaa ttccgggcac ggcagcgccg tggctcccca      600

cgctatacca tctacctggg cttcgggcag gacctgtcag ctgggaggcc caaggagaag      660

agcctggtcc tggtgaagct ggaaccctgg ctgtgccgag tgcacctaga gggcacgcag      720

cgtgagggtg tgtcttccct ggatagcagc agcctcagcc tctgcctgtc cagcgccaac      780

agcctctatg acgacatcga gtgcttcctt atggagctgg agcagcccgc ctag            834


<210> 37
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val Glu Thr 
1               5                   10                  15      


Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly Glu Ala 
            20                  25                  30          


Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser Pro Ser 
        35                  40                  45              


Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala Leu Asp 
    50                  55                  60                  


Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val Val Gly 
65                  70                  75                  80  


His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala Val Arg 
                85                  90                  95      


Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu Leu Pro 
            100                 105                 110         


Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His Val Ala 
        115                 120                 125             


Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala Arg Arg 
    130                 135                 140                 


Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro Gly Ser 
145                 150                 155                 160 


Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys Asp Thr 
                165                 170                 175     


Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu Phe Arg 
            180                 185                 190         


Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu Gly Phe 
        195                 200                 205             


Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu Val Leu 
    210                 215                 220                 


Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly Thr Gln 
225                 230                 235                 240 


Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu Cys Leu 
                245                 250                 255     


Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu Met Glu 
            260                 265                 270         


Leu Glu Gln Pro Ala 
        275         


<210> 38
<211> 1701
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
atggcaggca gacggcttac atggatcagc gagtttatcg taggtgccct ggactctgat       60

aagtacccct tggtaaaatg gcttgatcgg tcaacgggaa cttttctggc tcccgctgcg      120

agaaatgacg taataccact ggattccctg cagtttttca tagattttaa gagggagtgt      180

ttgtcaaagg ggctccaccc ccgagatctt ttgggtagtc caataactgc gttcggtaag      240

atttgtacaa ctagccgacg gctgagacga ttgcccggtg aagagtacga agttgtccaa      300

ggaatcaact gccggcggtg gcggcttctc tgcgccgaag tgaaagaatg ctggtggtgt      360

gtacacgcgc gaacacatct gcactccgga agcagccttt gggaaattct ctaccagcat      420

tccgtaagac ttgaaaagca ccgacgaagg cccaggccct ttgtaggaga gaacagtgat      480

tcttctgagg aagaccaccc tgctttctgc gatgtgcccg taacacaaac gggcgcggag      540

agcgaggaca gcggcgatga aggtccttcc accagacaca gcgcctcagg tgtccaaccg      600

gtagacgatg ctaatgccga ctcccctggt tctggagacg aaggtcccag cacccgccat      660

agcgacagtc aacctcctcc cgccgatgaa accactgtcc acacagacaa tgtagaggac      720

gatttgacac tccttgataa agagtccgcg tgcgcattga tgtatcacgt ggggcaggag      780

atggacatgc ttatgcgagc gatgtgcgat gaagacttgt ttgatttgct tgggatccct      840

gaggatgtaa tagccacaag tcagcctggt ggtgatacgg acgcctctgg cgttgttacg      900

gagggtagta ttgctgctag cgccgtgggc gcaggggttg aagatgtcta cttggcagga      960

gccctcgaag cacagaatgt cgcaggggag tatgtgcttg agatctctga tgaggaagta     1020

gacgatggcg ctggactccc tcccgcctca aggcggagac ccgttgttgg agagttcttg     1080

tgggacgacg gtcctaggcg ccacgaaagg ccaacgaccc gcagaattag gcacaggaaa     1140

ctcaggtctg cgtactacag agtagcacgg cccccagtga tgatcacgga caggctgggc     1200

gttgaggttt tttacttcgg aaggccggct atgagccttg aagtggaacg aaaagtattc     1260

atcttgtgta gccagaatcc gctggcagac atcagtcact cctgcctcca ttcacgaaaa     1320

gggcttcgag tcctgctgcc aaaaccggac gacaataata ctggtccggg agatgttaac     1380

ctcctcgcag cggtgttgag atcttttgca tcaggcttgg tgatagtctc actccgaagc     1440

ggaatctacg tgaagaacct ctgcaagagc accgtcctgt atcacggaaa caacccccca     1500

aaaaagtttg gcgttatatg cggactttca tccagagcag ttcttgacgt gtttaatgtt     1560

gcccaatacc ggattcaggg ccatgaacac atcaaaaaga caaccgtctt catcggggga     1620

gacccgactt cagcggagca atttgatatg gtgccactcg ttatcaagct tcggttgaga     1680

tcagtgacgt gcgacgatta a                                               1701


<210> 39
<211> 566
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Ala Gly Arg Arg Leu Thr Trp Ile Ser Glu Phe Ile Val Gly Ala 
1               5                   10                  15      


Leu Asp Ser Asp Lys Tyr Pro Leu Val Lys Trp Leu Asp Arg Ser Thr 
            20                  25                  30          


Gly Thr Phe Leu Ala Pro Ala Ala Arg Asn Asp Val Ile Pro Leu Asp 
        35                  40                  45              


Ser Leu Gln Phe Phe Ile Asp Phe Lys Arg Glu Cys Leu Ser Lys Gly 
    50                  55                  60                  


Leu His Pro Arg Asp Leu Leu Gly Ser Pro Ile Thr Ala Phe Gly Lys 
65                  70                  75                  80  


Ile Cys Thr Thr Ser Arg Arg Leu Arg Arg Leu Pro Gly Glu Glu Tyr 
                85                  90                  95      


Glu Val Val Gln Gly Ile Asn Cys Arg Arg Trp Arg Leu Leu Cys Ala 
            100                 105                 110         


Glu Val Lys Glu Cys Trp Trp Cys Val His Ala Arg Thr His Leu His 
        115                 120                 125             


Ser Gly Ser Ser Leu Trp Glu Ile Leu Tyr Gln His Ser Val Arg Leu 
    130                 135                 140                 


Glu Lys His Arg Arg Arg Pro Arg Pro Phe Val Gly Glu Asn Ser Asp 
145                 150                 155                 160 


Ser Ser Glu Glu Asp His Pro Ala Phe Cys Asp Val Pro Val Thr Gln 
                165                 170                 175     


Thr Gly Ala Glu Ser Glu Asp Ser Gly Asp Glu Gly Pro Ser Thr Arg 
            180                 185                 190         


His Ser Ala Ser Gly Val Gln Pro Val Asp Asp Ala Asn Ala Asp Ser 
        195                 200                 205             


Pro Gly Ser Gly Asp Glu Gly Pro Ser Thr Arg His Ser Asp Ser Gln 
    210                 215                 220                 


Pro Pro Pro Ala Asp Glu Thr Thr Val His Thr Asp Asn Val Glu Asp 
225                 230                 235                 240 


Asp Leu Thr Leu Leu Asp Lys Glu Ser Ala Cys Ala Leu Met Tyr His 
                245                 250                 255     


Val Gly Gln Glu Met Asp Met Leu Met Arg Ala Met Cys Asp Glu Asp 
            260                 265                 270         


Leu Phe Asp Leu Leu Gly Ile Pro Glu Asp Val Ile Ala Thr Ser Gln 
        275                 280                 285             


Pro Gly Gly Asp Thr Asp Ala Ser Gly Val Val Thr Glu Gly Ser Ile 
    290                 295                 300                 


Ala Ala Ser Ala Val Gly Ala Gly Val Glu Asp Val Tyr Leu Ala Gly 
305                 310                 315                 320 


Ala Leu Glu Ala Gln Asn Val Ala Gly Glu Tyr Val Leu Glu Ile Ser 
                325                 330                 335     


Asp Glu Glu Val Asp Asp Gly Ala Gly Leu Pro Pro Ala Ser Arg Arg 
            340                 345                 350         


Arg Pro Val Val Gly Glu Phe Leu Trp Asp Asp Gly Pro Arg Arg His 
        355                 360                 365             


Glu Arg Pro Thr Thr Arg Arg Ile Arg His Arg Lys Leu Arg Ser Ala 
    370                 375                 380                 


Tyr Tyr Arg Val Ala Arg Pro Pro Val Met Ile Thr Asp Arg Leu Gly 
385                 390                 395                 400 


Val Glu Val Phe Tyr Phe Gly Arg Pro Ala Met Ser Leu Glu Val Glu 
                405                 410                 415     


Arg Lys Val Phe Ile Leu Cys Ser Gln Asn Pro Leu Ala Asp Ile Ser 
            420                 425                 430         


His Ser Cys Leu His Ser Arg Lys Gly Leu Arg Val Leu Leu Pro Lys 
        435                 440                 445             


Pro Asp Asp Asn Asn Thr Gly Pro Gly Asp Val Asn Leu Leu Ala Ala 
    450                 455                 460                 


Val Leu Arg Ser Phe Ala Ser Gly Leu Val Ile Val Ser Leu Arg Ser 
465                 470                 475                 480 


Gly Ile Tyr Val Lys Asn Leu Cys Lys Ser Thr Val Leu Tyr His Gly 
                485                 490                 495     


Asn Asn Pro Pro Lys Lys Phe Gly Val Ile Cys Gly Leu Ser Ser Arg 
            500                 505                 510         


Ala Val Leu Asp Val Phe Asn Val Ala Gln Tyr Arg Ile Gln Gly His 
        515                 520                 525             


Glu His Ile Lys Lys Thr Thr Val Phe Ile Gly Gly Asp Pro Thr Ser 
    530                 535                 540                 


Ala Glu Gln Phe Asp Met Val Pro Leu Val Ile Lys Leu Arg Leu Arg 
545                 550                 555                 560 


Ser Val Thr Cys Asp Asp 
                565     


