                         SEQUENCE LISTING

<110>  LOGICBIO THERAPEUTICS, INC.
 
<120>  VIRAL VECTOR COMPOSITIONS AND METHODS OF USE THEREOF

<130>  2012538-0219

<140>  PCT/US2022/026988
<141>  2022-04-29

<150>  US 63/182,738
<151>  2021-04-30

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  7393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV-DJ-mha-mFAH (PM-0550)

<400>  1
cagatcctct acgccggacg catcgtggcc ggcatcaccg gcgccacagg tgcggttgct       60

ggcgcctata tcgccgacat caccgatggg gaagatcggg ctcgccactt cgggctcatg      120

agcgcttgtt tcggcgtggg tatggtggca ggccccgtgg ccgggggact gttgggcgcc      180

atctccttgc atgcaccatt ccttgcggcg gcggtgctca acggcctcaa cctactactg      240

ggctgcttcc taatgcagga gtcgcataag ggagagcgtc gaatggtgca ctctcagtac      300

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc      360

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg      420

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct      480

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg      540

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc      600

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag      660

gaagagtatg agccatattc aacgggaaac gtcgaggccg cgattaaatt ccaacatgga      720

tgctgattta tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat      780

ctatcgcttg tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag      840

cgttgccaat gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc      900

tcttccgacc atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc      960

gatccccgga aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat     1020

tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc     1080

ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt     1140

ggttgatgcg agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa     1200

agaaatgcat aaacttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc     1260

acttgataac cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt     1320

cggaatcgca gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc     1380

tccttcatta cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa     1440

attgcagttt catttgatgc tcgatgagtt tttctaactg tcagaccaag tttactcata     1500

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     1560

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     1620

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     1680

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     1740

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct     1800

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     1860

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     1920

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     1980

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     2040

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     2100

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     2160

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     2220

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     2280

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     2340

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     2400

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     2460

tcattaatgc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     2520

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     2580

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     2640

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     2700

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     2760

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagttggcc     2820

actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg     2880

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac     2940

tccatcacta ggggttcctt acgtaatgca tggatcccct agggcggccg cctgaaacta     3000

gacaaaaccc gtgtgactgg catcgattat tctatttgat ctagctagtc ctagcaaagt     3060

gacaactgct actcccctcc tacacagcca agattcctaa gttggcagtg gcatgcttaa     3120

tcctcaaagc caaagttact tggctccaag atttatagcc ttaaactgtg gcctcacatt     3180

ccttcctatc ttactttcct gcactggggt aaatgtctcc ttgctcttct tgctttctgt     3240

cctactgcag ggctcttgct gagctggtga agcacaagcc caaggctaca gcggagcaac     3300

tgaagactgt catggatgac tttgcacagt tcctggatac atgttgcaag gctgctgaca     3360

aggacacctg cttctcgact gaggtcagaa acgtttttgc attttgacga tgttcagttt     3420

ccattttctg tgcacgtggt caggtgtagc tctctggaac tcacacactg aataactcca     3480

ccaatctaga tgttgttctc tacgtaactg taatagaaac tgacttacgt agcttttaat     3540

ttttattttc tgccacactg ctgcctatta aatacctatt atcactattt ggtttcaaat     3600

ttgtgacaca gaagagcata gttagaaata cttgcaaagc ctagaatcat gaactcattt     3660

aaaccttgcc ctgaaatgtt tctttttgaa ttgagttatt ttacacatga atggacagtt     3720

accattatat atctgaatca tttcacattc cctcccatgg cctaacaaca gtttatcttc     3780

ttattttggg cacaacagat gtcagagagc ctgctttagg aattctaagt agaactgtaa     3840

ttaagcaatg caaggcacgt acgtttacta tgtcattgcc tatggctatg aagtgcaaat     3900

cctaacagtc ctgctaatac ttttctaaca tccatcattt ctttgttttc agggtccaaa     3960

ccttgtcact agatgcaaag acgccttagc cggaagcggc gccaccaatt tcagcctgct     4020

gaaacaggcc ggcgacgtgg aagagaaccc tggcccttcc tttattccag tggccgagga     4080

ctccgacttt cccatccaaa acctgcccta tggtgttttc tccactcaaa gcaacccaaa     4140

gccacggatt ggtgtagcca tcggtgacca gatcttggac ctgagtgtca ttaaacacct     4200

ctttaccgga cctgcccttt ccaaacatca acatgtcttc gatgagacaa ctctcaataa     4260

cttcatgggt ctgggtcaag ctgcatggaa ggaggcaaga gcatccttac agaacttact     4320

gtctgccagc caagcccggc tcagagatga caaggagctt cggcagcgtg cattcacctc     4380

ccaggcttct gcgacaatgc accttcctgc taccatagga gactacacgg acttctactc     4440

ttctcggcag catgccacca atgttggcat tatgttcaga ggcaaggaga atgcgctgtt     4500

gccaaattgg ctccacttac ctgtgggata ccatggccga gcttcctcca ttgtggtatc     4560

tggaaccccg attcgaagac ccatggggca gatgagacct gataactcaa agcctcctgt     4620

gtatggtgcc tgcagactct tagacatgga gttggaaatg gctttcttcg taggccctgg     4680

gaacagattc ggagagccaa tccccatttc caaagcccat gaacacattt tcgggatggt     4740

cctcatgaac gactggagcg cacgagacat ccagcaatgg gagtacgtcc cacttgggcc     4800

attcctgggg aaaagctttg gaaccacaat ctccccgtgg gtggtgccta tggatgccct     4860

catgcccttt gtggtgccaa acccaaagca ggaccccaag cccttgccat atctctgcca     4920

cagccagccc tacacatttg atatcaacct gtctgtctct ttgaaaggag aaggaatgag     4980

ccaggcggct accatctgca ggtctaactt taagcacatg tactggacca tgctgcagca     5040

actcacacac cactctgtta atggatgcaa cctgagacct ggggacctct tggcttctgg     5100

aaccatcagt ggatcagacc ctgaaagctt tggctccatg ctggaactgt cctggaaggg     5160

aacaaaggcc atcgatgtgg ggcaggggca gaccaggacc ttcctgctgg acggcgatga     5220

agtcatcata acaggtcact gccaggggga cggctaccgt gttggctttg gccagtgtgc     5280

tgggaaagtg ctgcctgccc tttcaccagc ctaaacacat cacaaccaca accttctcag     5340

gtaactatac ttgggactta aaaaacataa tcataatcat ttttcctaaa acgatcaaga     5400

ctgataacca tttgacaaga gccatacaga caagcaccag ctggcactct taggtcttca     5460

cgtatggtca tcagtttggg ttccatttgt agataagaaa ctgaacatat aaaggtctag     5520

gttaatgcaa tttacacaaa aggagaccaa accagggaga gaaggaacca aaattaaaaa     5580

ttcaaaccag agcaaaggag ttagccctgg ttttgctctg acttacatga accactatgt     5640

ggagtcctcc atgttagcct agtcaagctt atcctctgga tgaagttgaa accatatgaa     5700

ggaatatttg gggggtgggt caaaacagtt gtgtatcaat gattccatgt ggtttgaccc     5760

aatcattctg tgaatccatt tcaacagaag atacaacggg ttctgtttca taataagtga     5820

tccacttcca aatttctgat gtgccccatg ctaagcttta acagaattta tcttcttatg     5880

acaaagcagc ctcctttgaa aatatagcca actgcacaca gctatgttga tcaattttgt     5940

ttataatctt gcagaagaga attttttaaa atagggcaat aatggaaggc tttggcaaaa     6000

aaattgtttc tccatatgaa aacaaaaaac ttattttttt attcaagcaa agaacctata     6060

gacataaggc tatttcaaaa ttatttcagt tttagaaaga attgaaagtt ttgtagcatt     6120

ctgagaagac agctttcatt tgtaatcata ggtaatatgt aggtcctcag aaatggtgag     6180

acccctgact ttgacacttg gggactctga gggaccagtg atgaagaggg cacaacttat     6240

atcacacatg cacgagttgg ggtgagaggg tgtcacaaca tctatcagtg tgtcatctgc     6300

ccaccaagta acagatgtca gctaagacta ggtcatgtgt aggctgtcta caccagtgaa     6360

aatcgcaaaa agaatctaag aaattccaca tttctagaaa ataggtttgg aaaccgtatt     6420

ccattttaca aaggacactt acatttctct ttttgttttc caggctaccc tgagaaaaaa     6480

agacatgaag actcaggact catcttttct gttggtgtaa aatcaacacc ctaaggaaca     6540

caaatttctt taaacatttg acttcttgtc tctgtgctgc aattaataaa aaatggaaag     6600

aatctactct gtggttcaga actctatctt ccaaaggcgc gcttcaccct agcagcctct     6660

ttggctcaga ggaatccctg cctttcctcc cttcatctca gcagagaatg tagttccaca     6720

tgggcaacac aatgaaaata aacgttaata ctctcccatc ttatgggtgg tgaccctaga     6780

aaccaatact tcaacattac gagaattctg aatgagagac taaaagctta tgaactgtgg     6840

ctttcctttg tcagtgggac tctaagaatg agttggggac aaaagagata ggaatggctt     6900

taaaggtgac tagttgaact gataaagtaa atgaactgag gaaaaaaaat atcactcaac     6960

ctgcagggga cgtcctacgt aatgcatagg aacccctagt gatggagttg gccactccct     7020

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     7080

ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aagaattaat     7140

tccgtgtatt ctatagtgtc acctaaatcg tatgtgtatg atacataagg ttatgtatta     7200

attgtagccg cgttctaacg acaatatgta caagcctaat tgtgtagcat ctggcttact     7260

gaagcagacc ctatcatctc tctcgtaaac tgccgtcaga gtcggtttgg ttggacgaac     7320

cttctgagtt tctggtaacg ccgtcccgca cccggaaatg gtcagcgaac caatcagcag     7380

ggtcatcgct agc                                                        7393


<210>  2
<211>  7393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV-DJ-mha-hFAH (PM-0549)

<400>  2
cagatcctct acgccggacg catcgtggcc ggcatcaccg gcgccacagg tgcggttgct       60

ggcgcctata tcgccgacat caccgatggg gaagatcggg ctcgccactt cgggctcatg      120

agcgcttgtt tcggcgtggg tatggtggca ggccccgtgg ccgggggact gttgggcgcc      180

atctccttgc atgcaccatt ccttgcggcg gcggtgctca acggcctcaa cctactactg      240

ggctgcttcc taatgcagga gtcgcataag ggagagcgtc gaatggtgca ctctcagtac      300

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc      360

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg      420

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct      480

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg      540

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc      600

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag      660

gaagagtatg agccatattc aacgggaaac gtcgaggccg cgattaaatt ccaacatgga      720

tgctgattta tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat      780

ctatcgcttg tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag      840

cgttgccaat gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc      900

tcttccgacc atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc      960

gatccccgga aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat     1020

tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc     1080

ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt     1140

ggttgatgcg agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa     1200

agaaatgcat aaacttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc     1260

acttgataac cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt     1320

cggaatcgca gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc     1380

tccttcatta cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa     1440

attgcagttt catttgatgc tcgatgagtt tttctaactg tcagaccaag tttactcata     1500

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct     1560

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga     1620

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg     1680

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc     1740

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct     1800

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc     1860

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt     1920

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg     1980

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct     2040

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag     2100

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag     2160

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg     2220

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg     2280

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac     2340

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt     2400

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     2460

tcattaatgc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     2520

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     2580

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     2640

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     2700

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     2760

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagttggcc     2820

actccctctc tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg     2880

gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac     2940

tccatcacta ggggttcctt acgtaatgca tggatcccct agggcggccg cctgaaacta     3000

gacaaaaccc gtgtgactgg catcgattat tctatttgat ctagctagtc ctagcaaagt     3060

gacaactgct actcccctcc tacacagcca agattcctaa gttggcagtg gcatgcttaa     3120

tcctcaaagc caaagttact tggctccaag atttatagcc ttaaactgtg gcctcacatt     3180

ccttcctatc ttactttcct gcactggggt aaatgtctcc ttgctcttct tgctttctgt     3240

cctactgcag ggctcttgct gagctggtga agcacaagcc caaggctaca gcggagcaac     3300

tgaagactgt catggatgac tttgcacagt tcctggatac atgttgcaag gctgctgaca     3360

aggacacctg cttctcgact gaggtcagaa acgtttttgc attttgacga tgttcagttt     3420

ccattttctg tgcacgtggt caggtgtagc tctctggaac tcacacactg aataactcca     3480

ccaatctaga tgttgttctc tacgtaactg taatagaaac tgacttacgt agcttttaat     3540

ttttattttc tgccacactg ctgcctatta aatacctatt atcactattt ggtttcaaat     3600

ttgtgacaca gaagagcata gttagaaata cttgcaaagc ctagaatcat gaactcattt     3660

aaaccttgcc ctgaaatgtt tctttttgaa ttgagttatt ttacacatga atggacagtt     3720

accattatat atctgaatca tttcacattc cctcccatgg cctaacaaca gtttatcttc     3780

ttattttggg cacaacagat gtcagagagc ctgctttagg aattctaagt agaactgtaa     3840

ttaagcaatg caaggcacgt acgtttacta tgtcattgcc tatggctatg aagtgcaaat     3900

cctaacagtc ctgctaatac ttttctaaca tccatcattt ctttgttttc agggtccaaa     3960

ccttgtcact agatgcaaag acgccttagc cggaagcggc gccaccaatt tcagcctgct     4020

gaaacaggcc ggcgacgtgg aagagaaccc tggcccttcc ttcatcccgg tggccgagga     4080

ttccgacttc cccatccaca acctgcccta cggcgtcttc tcgaccagag gcgacccaag     4140

accgaggata ggtgtggcca ttggcgacca gatcctggac ctcagcatca tcaagcacct     4200

ctttactggt cctgtcctct ccaaacacca ggatgtcttc aatcagccta cactcaacag     4260

cttcatgggc ctgggtcagg ctgcctggaa ggaggcgaga gtgttcttgc agaacttgct     4320

gtctgtgagc caagccaggc tcagagatga caccgaactt cggaagtgtg cattcatctc     4380

ccaggcttct gccacgatgc accttccagc caccatagga gactacacag acttctattc     4440

ctctcggcag catgctacca acgtcggaat catgttcagg gacaaggaga atgcgttgat     4500

gccaaattgg ctgcacttac cagtgggcta ccatggccgt gcctcctctg tcgtggtgtc     4560

tggcacccca atccgaaggc ccatgggaca gatgaaacct gatgactcta agcctcccgt     4620

atatggtgcc tgcaagctct tggacatgga gctggaaatg gctttttttg taggccctgg     4680

aaacagattg ggagagccga tccccatttc caaggcccat gagcacattt ttggaatggt     4740

ccttatgaac gactggagtg cacgagacat tcagaagtgg gagtatgtcc ctctcgggcc     4800

attccttggg aagagttttg ggaccactgt ctctccgtgg gtggtgccca tggatgctct     4860

catgcccttt gctgtgccca acccgaagca ggaccccagg cccctgccgt atctgtgcca     4920

tgacgagccc tacacatttg acatcaacct ctctgttaac ctgaaaggag aaggaatgag     4980

ccaggcggct accatatgca agtccaattt taagtacatg tactggacga tgctgcagca     5040

gctcactcac cactctgtca acggctgcaa cctgcggccg ggggacctcc tggcttctgg     5100

gaccatcagc gggccggagc cagaaaactt cggctccatg ttggaactgt cgtggaaggg     5160

aacgaagccc atagacctgg ggaatggtca gaccaggaag tttctgctgg acggggatga     5220

agtcatcata acagggtact gccaggggga tggttaccgc atcggctttg gccagtgtgc     5280

tggaaaagtg ctgcctgctc tcctgccatc ataaacacat cacaaccaca accttctcag     5340

gtaactatac ttgggactta aaaaacataa tcataatcat ttttcctaaa acgatcaaga     5400

ctgataacca tttgacaaga gccatacaga caagcaccag ctggcactct taggtcttca     5460

cgtatggtca tcagtttggg ttccatttgt agataagaaa ctgaacatat aaaggtctag     5520

gttaatgcaa tttacacaaa aggagaccaa accagggaga gaaggaacca aaattaaaaa     5580

ttcaaaccag agcaaaggag ttagccctgg ttttgctctg acttacatga accactatgt     5640

ggagtcctcc atgttagcct agtcaagctt atcctctgga tgaagttgaa accatatgaa     5700

ggaatatttg gggggtgggt caaaacagtt gtgtatcaat gattccatgt ggtttgaccc     5760

aatcattctg tgaatccatt tcaacagaag atacaacggg ttctgtttca taataagtga     5820

tccacttcca aatttctgat gtgccccatg ctaagcttta acagaattta tcttcttatg     5880

acaaagcagc ctcctttgaa aatatagcca actgcacaca gctatgttga tcaattttgt     5940

ttataatctt gcagaagaga attttttaaa atagggcaat aatggaaggc tttggcaaaa     6000

aaattgtttc tccatatgaa aacaaaaaac ttattttttt attcaagcaa agaacctata     6060

gacataaggc tatttcaaaa ttatttcagt tttagaaaga attgaaagtt ttgtagcatt     6120

ctgagaagac agctttcatt tgtaatcata ggtaatatgt aggtcctcag aaatggtgag     6180

acccctgact ttgacacttg gggactctga gggaccagtg atgaagaggg cacaacttat     6240

atcacacatg cacgagttgg ggtgagaggg tgtcacaaca tctatcagtg tgtcatctgc     6300

ccaccaagta acagatgtca gctaagacta ggtcatgtgt aggctgtcta caccagtgaa     6360

aatcgcaaaa agaatctaag aaattccaca tttctagaaa ataggtttgg aaaccgtatt     6420

ccattttaca aaggacactt acatttctct ttttgttttc caggctaccc tgagaaaaaa     6480

agacatgaag actcaggact catcttttct gttggtgtaa aatcaacacc ctaaggaaca     6540

caaatttctt taaacatttg acttcttgtc tctgtgctgc aattaataaa aaatggaaag     6600

aatctactct gtggttcaga actctatctt ccaaaggcgc gcttcaccct agcagcctct     6660

ttggctcaga ggaatccctg cctttcctcc cttcatctca gcagagaatg tagttccaca     6720

tgggcaacac aatgaaaata aacgttaata ctctcccatc ttatgggtgg tgaccctaga     6780

aaccaatact tcaacattac gagaattctg aatgagagac taaaagctta tgaactgtgg     6840

ctttcctttg tcagtgggac tctaagaatg agttggggac aaaagagata ggaatggctt     6900

taaaggtgac tagttgaact gataaagtaa atgaactgag gaaaaaaaat atcactcaac     6960

ctgcagggga cgtcctacgt aatgcatagg aacccctagt gatggagttg gccactccct     7020

ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct     7080

ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aagaattaat     7140

tccgtgtatt ctatagtgtc acctaaatcg tatgtgtatg atacataagg ttatgtatta     7200

attgtagccg cgttctaacg acaatatgta caagcctaat tgtgtagcat ctggcttact     7260

gaagcagacc ctatcatctc tctcgtaaac tgccgtcaga gtcggtttgg ttggacgaac     7320

cttctgagtt tctggtaacg ccgtcccgca cccggaaatg gtcagcgaac caatcagcag     7380

ggtcatcgct agc                                                        7393


<210>  3
<211>  10221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV-DJ-mha-mFAH (PM-0549)

<400>  3
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct       60

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta      120

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct      180

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg      240

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa      300

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt      360

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta      420

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca      480

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta      540

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct      600

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg      660

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac      720

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact      780

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa      840

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt      900

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat      960

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     1020

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     1080

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     1140

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     1200

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     1260

tgagagtgca ccattcgacg ctctccctta tgcgactcct gcattaggaa gcagcccagt     1320

agtaggttga ggccgttgag caccgccgcc gcaaggaatg gtgcatgcaa ggagatggcg     1380

cccaacagtc ccccggccac ggggcctgcc accataccca cgccgaaaca agcgctcatg     1440

agcccgaagt ggcgagcccg atcttcccca tcggtgatgt cggcgatata ggcgccagca     1500

accgcacctg tggcgccggt gggtcaccaa gcaggaagtc aaagactttt tccggtgggc     1560

aaaggatcac gtggttgagg tggagcatga attctacgtc aaaaagggtg gagccaagaa     1620

aagacccgcc cccagtgacg cagatataag tgagcccaaa cgggtgcgcg agtcagttgc     1680

gcagccatcg acgtcagacg cggaagcttc gatcaactac gcagacaggt accaaaacaa     1740

atgttctcgt cacgtgggca tgaatctgat gctgtttccc tgcagacaat gcgagagaat     1800

gaatcagaat tcaaatatct gcttcactca cggacagaaa gactgtttag agtgctttcc     1860

cgtgtcagaa tctcaacccg tttctgtcgt caaaaaggcg tatcagaaac tgtgctacat     1920

tcatcatatc atgggaaagg tgccagacgc ttgcactgcc tgcgatctgg tcaatgtgga     1980

tttggatgac tgcatctttg aacaataaat gatttaaatc aggtatggct gccgatggtt     2040

atcttccaga ttggctcgag gacactctct ctgaaggaat aagacagtgg tggaagctca     2100

aacctggccc accaccacca aagcccgcag agcggcataa ggacgacagc aggggtcttg     2160

tgcttcctgg gtacaagtac ctcggaccct tcaacggact cgacaaggga gagccggtca     2220

acgaggcaga cgccgcggcc ctcgagcacg acaaagccta cgaccggcag ctcgacagcg     2280

gagacaaccc gtacctcaag tacaaccacg ccgacgccga gttccaggag cggctcaaag     2340

aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaaa aagaggcttc     2400

ttgaacctct tggtctggtt gaggaagcgg ctaagacggc tcctggaaag aagaggcctg     2460

tagagcactc tcctgtggag ccagactcct cctcgggaac cggaaaggcg ggccagcagc     2520

ctgcaagaaa aagattgaat tttggtcaga ctggagacgc agactcagtc ccagaccctc     2580

aaccaatcgg agaacctccc gcagccccct caggtgtggg atctcttaca atggctgcag     2640

gcggtggcgc accaatggca gacaataacg agggcgccga cggagtgggt aattcctcgg     2700

gaaattggca ttgcgattcc acatggatgg gcgacagagt catcaccacc agcacccgaa     2760

cctgggccct gcccacctac aacaaccacc tctacaagca aatctccaac agcacatctg     2820

gaggatcttc aaatgacaac gcctacttcg gctacagcac cccctggggg tattttgact     2880

ttaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc aacaacaact     2940

ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc aaggaggtca     3000

cgcagaatga aggcaccaag accatcgcca ataacctcac cagcaccatc caggtgttta     3060

cggactcgga gtaccagctg ccgtacgttc tcggctctgc ccaccagggc tgcctgcctc     3120

cgttcccggc ggacgtgttc atgattcccc agtacggcta cctaacactc aacaacggta     3180

gtcaggccgt gggacgctcc tccttctact gcctggaata ctttccttcg cagatgctga     3240

gaaccggcaa caacttccag tttacttaca ccttcgagga cgtgcctttc cacagcagct     3300

acgcccacag ccagagcttg gaccggctga tgaatcctct gattgaccag tacctgtact     3360

acttgtctcg gactcaaaca acaggaggca cgacaaatac gcagactctg ggcttcagcc     3420

aaggtgggcc taatacaatg gccaatcagg caaagaactg gctgccagga ccctgttacc     3480

gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac tcgtggactg     3540

gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc ccggccatgg     3600

caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc atctttggga     3660

agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca gacgaagagg     3720

aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct accaacctcc     3780

agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt cttccaggca     3840

tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag attccacaca     3900

cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa caccctccgc     3960

ctcagatcct gatcaagaac acgcctgtac ctgcggatcc tccgaccacc ttcaaccagt     4020

caaagctgaa ctctttcatc acccagtatt ctactggcca agtcagcgtg gagatcgagt     4080

gggagctgca gaaggaaaac agcaagcgct ggaaccccga gatccagtac acctccaact     4140

actacaaatc tacaagtgtg gactttgctg ttaatacaga aggcgtgtac tctgaacccc     4200

gccccattgg cacccgttac ctcacccgta atctgtaatt gcttgttaat caataaaccg     4260

tttaattcgt ttcagttgaa ctttggtctc tgcgtatttc tttcttatct agtttccata     4320

tgcatgtaga taagtagcat ggcgggttaa tcattaacta accggtacct ctagaactat     4380

agctagcgat gaccctgctg attggttcgc tgaccatttc cgggtgcggg acggcgttac     4440

cagaaactca gaaggttcgt ccaaccaaac cgactctgac ggcagtttac gagagagatg     4500

atagggtctg cttcagtaag ccagatgcta cacaattagg cttgtacata ttgtcgttag     4560

aacgcggcta caattaatac ataaccttat gtatcataca catacgattt aggtgacact     4620

atagaataca cggaattaat tcttggccac tccctctctg cgcgctcgct cgctcactga     4680

ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga     4740

gcgagcgcgc agagagggag tggccaactc catcactagg ggttccttac cgactgaaac     4800

tagacaaaac ccgtgtgact ggcatcgatt attctatttg atctagctag tcctagcaaa     4860

gtgacaactg ctactcccct cctacacagc caagattcct aagttggcag tggcatgctt     4920

aatcctcaaa gccaaagtta cttggctcca agatttatag ccttaaactg tggcctcaca     4980

ttccttccta tcttactttc ctgcactggg gtaaatgtct ccttgctctt cttgctttct     5040

gtcctactgc agggctcttg ctgagctggt gaagcacaag cccaaggcta cagcggagca     5100

actgaagact gtcatggatg actttgcaca gttcctggat acatgttgca aggctgctga     5160

caaggacacc tgcttctcga ctgaggtcag aaacgttttt gcattttgac gatgttcagt     5220

ttccattttc tgtgcacgtg gtcaggtgta gctctctgga actcacacac tgaataactc     5280

caccaatcta gatgttgttc tctacgtaac tgtaatagaa actgacttac gtagctttta     5340

atttttattt tctgccacac tgctgcctat taaataccta ttatcactat ttggtttcaa     5400

atttgtgaca cagaagagca tagttagaaa tacttgcaaa gcctagaatc atgaactcat     5460

ttaaaccttg ccctgaaatg tttctttttg aattgagtta ttttacacat gaatggacag     5520

ttaccattat atatctgaat catttcacat tccctcccat ggcctaacaa cagtttatct     5580

tcttattttg ggcacaacag atgtcagaga gcctgcttta ggaattctaa gtagaactgt     5640

aattaagcaa tgcaaggcac gtacgtttac tatgtcattg cctatggcta tgaagtgcaa     5700

atcctaacag tcctgctaat acttttctaa catccatcat ttctttgttt tcagggtcca     5760

aaccttgtca ctagatgcaa agacgcctta gccggaagcg gcgccaccaa tttcagcctg     5820

ctgaaacagg ccggcgacgt ggaagagaac cctggccctt cctttattcc agtggccgag     5880

gactccgact ttcccatcca aaacctgccc tatggtgttt tctccactca aagcaaccca     5940

aagccacgga ttggtgtagc catcggtgac cagatcttgg acctgagtgt cattaaacac     6000

ctctttaccg gacctgccct ttccaaacat caacatgtct tcgatgagac aactctcaat     6060

aacttcatgg gtctgggtca agctgcatgg aaggaggcaa gagcatcctt acagaactta     6120

ctgtctgcca gccaagcccg gctcagagat gacaaggagc ttcggcagcg tgcattcacc     6180

tcccaggctt ctgcgacaat gcaccttcct gctaccatag gagactacac ggacttctac     6240

tcttctcggc agcatgccac caatgttggc attatgttca gaggcaagga gaatgcgctg     6300

ttgccaaatt ggctccactt acctgtggga taccatggcc gagcttcctc cattgtggta     6360

tctggaaccc cgattcgaag acccatgggg cagatgagac ctgataactc aaagcctcct     6420

gtgtatggtg cctgcagact cttagacatg gagttggaaa tggctttctt cgtaggccct     6480

gggaacagat tcggagagcc aatccccatt tccaaagccc atgaacacat tttcgggatg     6540

gtcctcatga acgactggag cgcacgagac atccagcaat gggagtacgt cccacttggg     6600

ccattcctgg ggaaaagctt tggaaccaca atctccccgt gggtggtgcc tatggatgcc     6660

ctcatgccct ttgtggtgcc aaacccaaag caggacccca agcccttgcc atatctctgc     6720

cacagccagc cctacacatt tgatatcaac ctgtctgtct ctttgaaagg agaaggaatg     6780

agccaggcgg ctaccatctg caggtctaac tttaagcaca tgtactggac catgctgcag     6840

caactcacac accactctgt taatggatgc aacctgagac ctggggacct cttggcttct     6900

ggaaccatca gtggatcaga ccctgaaagc tttggctcca tgctggaact gtcctggaag     6960

ggaacaaagg ccatcgatgt ggggcagggg cagaccagga ccttcctgct ggacggcgat     7020

gaagtcatca taacaggtca ctgccagggg gacggctacc gtgttggctt tggccagtgt     7080

gctgggaaag tgctgcctgc cctttcacca gcctaaacac atcacaacca caaccttctc     7140

aggtaactat acttgggact taaaaaacat aatcataatc atttttccta aaacgatcaa     7200

gactgataac catttgacaa gagccataca gacaagcacc agctggcact cttaggtctt     7260

cacgtatggt catcagtttg ggttccattt gtagataaga aactgaacat ataaaggtct     7320

aggttaatgc aatttacaca aaaggagacc aaaccaggga gagaaggaac caaaattaaa     7380

aattcaaacc agagcaaagg agttagccct ggttttgctc tgacttacat gaaccactat     7440

gtggagtcct ccatgttagc ctagtcaagc ttatcctctg gatgaagttg aaaccatatg     7500

aaggaatatt tggggggtgg gtcaaaacag ttgtgtatca atgattccat gtggtttgac     7560

ccaatcattc tgtgaatcca tttcaacaga agatacaacg ggttctgttt cataataagt     7620

gatccacttc caaatttctg atgtgcccca tgctaagctt taacagaatt tatcttctta     7680

tgacaaagca gcctcctttg aaaatatagc caactgcaca cagctatgtt gatcaatttt     7740

gtttataatc ttgcagaaga gaatttttta aaatagggca ataatggaag gctttggcaa     7800

aaaaattgtt tctccatatg aaaacaaaaa acttattttt ttattcaagc aaagaaccta     7860

tagacataag gctatttcaa aattatttca gttttagaaa gaattgaaag ttttgtagca     7920

ttctgagaag acagctttca tttgtaatca taggtaatat gtaggtcctc agaaatggtg     7980

agacccctga ctttgacact tggggactct gagggaccag tgatgaagag ggcacaactt     8040

atatcacaca tgcacgagtt ggggtgagag ggtgtcacaa catctatcag tgtgtcatct     8100

gcccaccaag taacagatgt cagctaagac taggtcatgt gtaggctgtc tacaccagtg     8160

aaaatcgcaa aaagaatcta agaaattcca catttctaga aaataggttt ggaaaccgta     8220

ttccatttta caaaggacac ttacatttct ctttttgttt tccaggctac cctgagaaaa     8280

aaagacatga agactcagga ctcatctttt ctgttggtgt aaaatcaaca ccctaaggaa     8340

cacaaatttc tttaaacatt tgacttcttg tctctgtgct gcaattaata aaaaatggaa     8400

agaatctact ctgtggttca gaactctatc ttccaaaggc gcgcttcacc ctagcagcct     8460

ctttggctca gaggaatccc tgcctttcct cccttcatct cagcagagaa tgtagttcca     8520

catgggcaac acaatgaaaa taaacgttaa tactctccca tcttatgggt ggtgacccta     8580

gaaaccaata cttcaacatt acgagaattc tgaatgagag actaaaagct tatgaactgt     8640

ggctttcctt tgtcagtggg actctaagaa tgagttgggg acaaaagaga taggaatggc     8700

tttaaaggtg actagttgaa ctgataaagt aaatgaactg aggaaaaaaa atatcactca     8760

atcggtaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     8820

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     8880

agcgagcgag cgcgcagaga gggagtggcc aactttttgc aaaagcctag gcctccaaaa     8940

aagcctcctc actacttctg gaatagctca gaggccgagg cggcctcggc ctctgcataa     9000

ataaaaaaaa ttagtcagcc atggggcgga gaatgggcgg aactgggcgg agttaggggc     9060

gggatgggcg gagttagggg cgggactatg gttgctgact aattgagatg catgctttgc     9120

atacttctgc ctgctgggga gcctggggac tttccacacc tggttgctga ctaattgaga     9180

tgcatgcttt gcatacttct gcctgctggg gagcctgggg actttccaca ccctaactga     9240

cacacattcc acagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     9300

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     9360

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     9420

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     9480

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     9540

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     9600

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     9660

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     9720

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     9780

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     9840

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     9900

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     9960

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg    10020

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag    10080

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag    10140

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat    10200

gaagttttaa atcaatctaa a                                              10221


<210>  4
<211>  1254
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human FAH

<400>  4
tccttcatcc cggtggccga ggattccgac ttccccatcc acaacctgcc ctacggcgtc       60

ttctcgacca gaggcgaccc aagaccgagg ataggtgtgg ccattggcga ccagatcctg      120

gacctcagca tcatcaagca cctctttact ggtcctgtcc tctccaaaca ccaggatgtc      180

ttcaatcagc ctacactcaa cagcttcatg ggcctgggtc aggctgcctg gaaggaggcg      240

agagtgttct tgcagaactt gctgtctgtg agccaagcca ggctcagaga tgacaccgaa      300

cttcggaagt gtgcattcat ctcccaggct tctgccacga tgcaccttcc agccaccata      360

ggagactaca cagacttcta ttcctctcgg cagcatgcta ccaacgtcgg aatcatgttc      420

agggacaagg agaatgcgtt gatgccaaat tggctgcact taccagtggg ctaccatggc      480

cgtgcctcct ctgtcgtggt gtctggcacc ccaatccgaa ggcccatggg acagatgaaa      540

cctgatgact ctaagcctcc cgtatatggt gcctgcaagc tcttggacat ggagctggaa      600

atggcttttt ttgtaggccc tggaaacaga ttgggagagc cgatccccat ttccaaggcc      660

catgagcaca tttttggaat ggtccttatg aacgactgga gtgcacgaga cattcagaag      720

tgggagtatg tccctctcgg gccattcctt gggaagagtt ttgggaccac tgtctctccg      780

tgggtggtgc ccatggatgc tctcatgccc tttgctgtgc ccaacccgaa gcaggacccc      840

aggcccctgc cgtatctgtg ccatgacgag ccctacacat ttgacatcaa cctctctgtt      900

aacctgaaag gagaaggaat gagccaggcg gctaccatat gcaagtccaa ttttaagtac      960

atgtactgga cgatgctgca gcagctcact caccactctg tcaacggctg caacctgcgg     1020

ccgggggacc tcctggcttc tgggaccatc agcgggccgg agccagaaaa cttcggctcc     1080

atgttggaac tgtcgtggaa gggaacgaag cccatagacc tggggaatgg tcagaccagg     1140

aagtttctgc tggacgggga tgaagtcatc ataacagggt actgccaggg ggatggttac     1200

cgcatcggct ttggccagtg tgctggaaaa gtgctgcctg ctctcctgcc atca           1254


<210>  5
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human FAH Codon optimized variant 3

<400>  5
tccttcattc ctgtggccga ggattctgac tttcccattc acaacctgcc ctatggcgtc       60

ttttcaacca ggggagatcc caggcccaga atcggggtgg ccattggaga tcagatcctg      120

gacctgtcaa tcatcaagca cctgtttaca ggccctgtgc tgagcaagca ccaggatgtg      180

ttcaaccagc caactctgaa cagcttcatg gggctggggc aggctgcctg gaaggaggca      240

agggtgtttc tgcagaatct gctgagcgtg tcacaggcta ggctgaggga tgataccgag      300

ctgaggaagt gtgcatttat ctcacaggca tcagccacaa tgcatctgcc agctacaatc      360

ggcgactata ccgactttta ctcaagcagg cagcatgcca ccaatgtggg catcatgttc      420

agggacaaag agaatgccct gatgccaaat tggctgcacc tgcctgtggg ctatcatggc      480

agagccagct cagtggtggt gtcagggaca ccaattagga ggcctatggg ccagatgaag      540

cctgatgaca gcaaaccacc tgtctacggc gcctgcaagc tcctggatat ggaactggag      600

atggcttttt ttgtgggccc aggcaataga ctgggagagc ccattccaat ctcaaaggcc      660

catgaacata tctttggcat ggtcctgatg aatgactggt cagccagaga cattcagaag      720

tgggagtacg tgccactggg accatttctg ggaaagagct ttggcaccac agtgtcacca      780

tgggtggtgc ccatggatgc cctgatgccc tttgctgtgc caaatccaaa acaagacccc      840

aggcccctcc cctatctctg tcatgatgaa ccatatactt ttgacattaa cctgagcgtg      900

aacctgaaag gagaaggcat gagccaagcc gccactatct gtaagagcaa cttcaaatat      960

atgtactgga caatgctgca gcagctcacc caccatagcg tgaatgggtg taacctgagg     1020

ccaggcgacc tgctggcatc aggcactatt tcagggcctg agcctgaaaa ttttggatca     1080

atgctggagc tgtcatggaa gggaactaaa cccatcgacc tggggaatgg ccagaccaga     1140

aagtttctcc tggatggcga tgaggtgatc attacaggct actgtcaggg ggatggctat     1200

agaattggat ttggccaatg cgccggcaaa gtcctccctg ccctgctgcc cagc           1254


<210>  6
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human FAH Codon optimized variant 2

<400>  6
tccttcatcc cagtggctga agattctgac ttccccattc acaacctccc ttatggagtc       60

tttagcacaa gaggagaccc aagacctaga attggcgtgg ctattgggga tcagatcctg      120

gacctgagca ttatcaaaca tctctttaca ggcccagtcc tcagcaagca ccaagatgtg      180

ttcaatcaac ccacactgaa ctcatttatg gggctgggcc aagctgcctg gaaggaggca      240

agagtgtttc tccagaacct cctgtcagtg agccaggcca ggctgagaga tgacacagag      300

ctgaggaagt gtgcctttat ctcacaagcc agcgccacaa tgcacctgcc agcaaccatc      360

ggggactaca cagactttta cagcagcagg cagcacgcca ctaatgtggg catcatgttt      420

agagacaaag agaatgccct catgcctaac tggctgcatc tgccagtggg ctaccatggc      480

agagccagca gcgtggtggt gtctggcacc cctatcagga ggcccatggg ccagatgaag      540

cctgatgaca gcaagccacc tgtgtatggg gcatgtaagc tgctggacat ggagctggaa      600

atggctttct ttgtggggcc tgggaacagg ctgggcgaac caattcccat cagcaaagct      660

catgaacaca tttttgggat ggtgctcatg aatgactggt ctgccagaga catccagaag      720

tgggagtatg tccccctggg accattcctg ggcaagagct ttgggaccac tgtgtcacca      780

tgggtggtgc ccatggatgc cctgatgcca tttgctgtgc ctaatcccaa acaagatcca      840

aggccactgc cctacctctg ccacgatgag ccctacacat ttgatatcaa cctctctgtg      900

aatctgaagg gagaaggaat gagccaagct gctaccattt gcaaaagcaa ctttaagtat      960

atgtattgga ccatgctgca gcaactcacc caccacagcg tgaatggctg taacctgagg     1020

cctggcgacc tgctggcctc tggcaccatc agcggccctg aacctgagaa ctttggcagc     1080

atgctggagc tgagctggaa gggaaccaag cccattgacc tgggcaatgg acagaccagg     1140

aaattcctcc tggacgggga cgaggtgatc atcacaggct attgccaggg ggatgggtat     1200

aggattggct ttggccaatg tgccggcaaa gtgctgcctg ccctgctccc tagc           1254


<210>  7
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human FAH Codon optimized variant 1

<400>  7
tcctttattc ctgtggccga agatagcgac ttccctatcc ataacctccc atatggcgtc       60

ttctcaacca ggggcgaccc caggcccagg attggggtgg caattggaga ccagatcctg      120

gacctcagca tcattaagca cctctttaca ggacctgtgc tgagcaagca ccaggatgtg      180

ttcaaccagc ctaccctgaa tagctttatg ggactgggcc aggcagcatg gaaagaagcc      240

agagtgttcc tccagaatct gctgagcgtg agccaggcca ggctcaggga tgacacagaa      300

ctgaggaaat gtgccttcat ctcacaggca tcagccacaa tgcacctccc tgccacaatt      360

ggggactaca ctgacttcta cagcagcaga cagcatgcca ctaatgtggg gattatgttt      420

agagacaagg aaaatgccct catgccaaat tggctgcacc tgcctgtggg ctaccacggc      480

agagcctcat cagtggtggt gtcaggcaca ccaattagga ggccaatggg acagatgaag      540

cctgacgact caaagccacc agtctatggc gcctgcaaac tgctggacat ggagctggag      600

atggctttct ttgtggggcc tggcaacagg ctgggagaac caatccctat ttcaaaggcc      660

cacgagcaca tttttggcat ggtgctcatg aatgactggt ctgccagaga tatccagaag      720

tgggaatacg tgcccctggg cccttttctg ggcaagagct ttggcaccac agtgtcacct      780

tgggtggtcc caatggatgc cctgatgccc tttgccgtgc ccaaccccaa gcaggatccc      840

agaccactgc cctacctgtg ccacgatgag ccctatacct ttgacatcaa cctgtcagtc      900

aacctgaagg gggagggcat gagccaggcc gccactattt gcaagagcaa ctttaaatat      960

atgtactgga ctatgctcca acagctcact caccactcag tgaatggctg caatctgagg     1020

cctggcgacc tcctggctag cggcactatc tctggccctg aacctgagaa ctttgggagc     1080

atgctggagc tgtcatggaa agggacaaag cctattgacc tggggaatgg ccagacaagg     1140

aagtttctcc tggatggcga tgaggtcatc atcactgggt actgccaggg cgatggctac     1200

aggattggat ttggacagtg tgctggcaaa gtgctcccag ctctgctgcc ctca           1254


<210>  8
<211>  3102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Human truncated ATP7B

<400>  8
cctgagcagg agagacagat cacagccaga gaaggggcca gtcggaaaat cttatctaag       60

ctttctttgc ctacccgtgc ctgggaacca gcaatgaaga agagttttgc ttttgacaat      120

gttggctatg aaggtggtct ggatggcctg ggcccttctt ctcagccgca gaagtgcttc      180

ttacagatca aaggcatgac ctgtgcatcc tgtgtgtcta acatagaaag gaatctgcag      240

aaagaagctg gtgttctctc cgtgttggtt gccttgatgg caggaaaggc agagatcaag      300

tatgacccag aggtcatcca gcccctcgag atagctcagt tcatccagga cctgggtttt      360

gaggcagcag tcatggagga ctacgcaggc tccgatggca acattgagct gacaatcaca      420

gggatgacct gcgcgtcctg tgtccacaac atagagtcca aactcacgag gacaaatggc      480

atcacttatg cctccgttgc ccttgccacc agcaaagccc ttgttaagtt tgacccggaa      540

attatcggtc cacgggatat tatcaaaatt attgaggaaa ttggctttca tgcttccctg      600

gcccagagaa accccaacgc tcatcacttg gaccacaaga tggaaataaa gcagtggaag      660

aagtctttcc tgtgcagcct ggtgtttggc atccctgtca tggccttaat gatctatatg      720

ctgataccca gcaacgagcc ccaccagtcc atggtcctgg accacaacat cattccagga      780

ctgtccattc taaatctcat cttctttatc ttgtgtacct ttgtccagct cctcggtggg      840

tggtacttct acgttcaggc ctacaaatct ctgagacaca ggtcagccaa catggacgtg      900

ctcatcgtcc tggccacaag cattgcttat gtttattctc tggtcatcct ggtggttgct      960

gtggctgaga aggcggagag gagccctgtg acattcttcg acacgccccc catgctcttt     1020

gtgttcattg ccctgggccg gtggctggaa cacttggcaa agagcaaaac ctcagaagcc     1080

ctggctaaac tcatgtctct ccaagccaca gaagccaccg ttgtgaccct tggtgaggac     1140

aatttaatca tcagggagga gcaagtcccc atggagctgg tgcagcgggg cgatatcgtc     1200

aaggtggtcc ctgggggaaa gtttccagtg gatgggaaag tcctggaagg caataccatg     1260

gctgatgagt ccctcatcac aggagaagcc atgccagtca ctaagaaacc cggaagcact     1320

gtaattgcgg ggtctataaa tgcacatggc tctgtgctca ttaaagctac ccacgtgggc     1380

aatgacacca ctttggctca gattgtgaaa ctggtggaag aggctcagat gtcaaaggca     1440

cccattcagc agctggctga ccggtttagt ggatattttg tcccatttat catcatcatg     1500

tcaactttga cgttggtggt atggattgta atcggtttta tcgattttgg tgttgttcag     1560

agatactttc ctaaccccaa caagcacatc tcccagacag aggtgatcat ccggtttgct     1620

ttccagacgt ccatcacggt gctgtgcatt gcctgcccct gctccctggg gctggccacg     1680

cccacggctg tcatggtggg caccggggtg gccgcgcaga acggcatcct catcaaggga     1740

ggcaagcccc tggagatggc gcacaagata aagactgtga tgtttgacaa gactggcacc     1800

attacccatg gcgtccccag ggtcatgcgg gtgctcctgc tgggggatgt ggccacactg     1860

cccctcagga aggttctggc tgtggtgggg actgcggagg ccagcagtga acaccccttg     1920

ggcgtggcag tcaccaaata ctgtaaagag gaacttggaa cagagacctt gggatactgc     1980

acggacttcc aggcagtgcc aggctgtgga attgggtgca aagtcagcaa cgtggaaggc     2040

atcctggccc acagtgagcg ccctttgagt gcaccggcca gtcacctgaa tgaggctggc     2100

agccttcccg cagaaaaaga tgcagtcccc cagaccttct ctgtgctgat tggaaaccgt     2160

gagtggctga ggcgcaacgg tttaaccatt tctagcgatg tcagtgacgc tatgacagac     2220

cacgagatga aaggacagac agccatcctg gtggctattg acggtgtgct ctgtgggatg     2280

atcgcaatcg cagacgctgt caagcaggag gctgccctgg ctgtgcacac gctgcagagc     2340

atgggtgtgg acgtggttct gatcacgggg gacaaccgga agacagccag agctattgcc     2400

acccaggttg gcatcaacaa agtctttgca gaggtgctgc cttcgcacaa ggtggccaag     2460

gtccaggagc tccagaataa agggaagaaa gtcgccatgg tgggggatgg ggtcaatgac     2520

tccccggcct tggcccaggc agacatgggt gtggccattg gcaccggcac ggatgtggcc     2580

atcgaggcag ccgacgtcgt ccttatcaga aatgatttgc tggatgtggt ggctagcatt     2640

cacctttcca agaggactgt ccgaaggata cgcatcaacc tggtcctggc actgatttat     2700

aacctggttg ggatacccat tgcagcaggt gtcttcatgc ccatcggcat tgtgctgcag     2760

ccctggatgg gctcagcggc catggcagcc tcctctgtgt ctgtggtgct ctcatccctg     2820

cagctcaagt gctataagaa gcctgacctg gagaggtatg aggcacaggc gcatggccac     2880

atgaagcccc tgacggcatc ccaggtcagt gtgcacatag gcatggatga caggtggcgg     2940

gactccccca gggccacacc atgggaccag gtcagctatg tcagccaggt gtcgctgtcc     3000

tccctgacgt ccgacaagcc atctcggcac agcgctgcag cagacgatga tggggacaag     3060

tggtctctgc tcctgaatgg cagggatgag gagcagtaca tc                        3102


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  9
atgttccacg aagaagcca                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  10
tcagcaggct gaaattggt                                                    19


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  11
agctgtttct tactccattc tca                                               23


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: probe

<400>  12
aggcaacgtc atgggtgtga cttt                                              24


