
                                SEQUENCE LISTING

<110> Adverum Biotechnologies, Inc.

<120> METHODS OF TREATING OCULAR DISEASES USING AAV2 VARIANTS
      ENCODING AFLIBERCEPT
  
<130> 62700-20013.40

<140> Not Yet Assigned
<141> Concurrently Herewith 

<150> US 63/180,646
<151> 2021-04-27

<160> 41

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Leu Ala Leu Gly Glu Thr Thr Arg Pro Ala
 1               5                  10  


<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Leu Ala Asn Glu Thr Ile Thr Arg Pro Ala
 1               5                  10  


<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Leu Ala Lys Ala Gly Gln Ala Asn Asn Ala
 1               5                  10  


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Leu Ala Lys Asp Pro Lys Thr Thr Asn Ala
 1               5                  10  


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Lys Asp Thr Asp Thr Thr Arg
 1               5          


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Arg Ala Gly Gly Ser Val Gly
 1               5          


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Ala Val Asp Thr Thr Lys Phe
 1               5          


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Ser Thr Gly Lys Val Pro Asn
 1               5          


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Leu Ala Lys Asp Thr Asp Thr Thr Arg Ala
 1               5                  10  


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Leu Ala Arg Ala Gly Gly Ser Val Gly Ala
 1               5                  10  


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Leu Ala Ala Val Asp Thr Thr Lys Phe Ala
 1               5                  10  


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Leu Ala Ser Thr Gly Lys Val Pro Asn Ala
 1               5                  10  


<210> 13
<211> 735
<212> PRT
<213> Adeno-associated virus VP1 capsid

<400> 13
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr
            580                 585                 590         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp
        595                 600                 605             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr
    610                 615                 620                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys
625                 630                 635                 640 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn
                645                 650                 655     
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln
            660                 665                 670         
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys
        675                 680                 685             
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr
    690                 695                 700                 
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr
705                 710                 715                 720 
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu
                725                 730                 735 


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Leu Gly Glu Thr Thr Arg Pro
 1               5          


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Asn Glu Thr Ile Thr Arg Pro
 1               5          


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Lys Ala Gly Gln Ala Asn Asn
 1               5          


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Lys Asp Pro Lys Thr Thr Asn
 1               5          


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Lys Asp Thr Asp Thr Thr Arg
 1               5          


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Arg Ala Gly Gly Ser Val Gly
 1               5          


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Ala Val Asp Thr Thr Lys Phe
 1               5          


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Ser Thr Gly Lys Val Pro Asn
 1               5          


<210> 22
<211> 293
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60
aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120
gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180
ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240
acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca        293

<210> 23
<211> 220
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
tgctgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60
ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120
actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg                       220

<210> 24
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca 60
aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac 120
tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa 180
ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg 240
gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt 300
gagacggcgg atggtcga                                               318

<210> 25
<211> 102
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
ccagctgttg gggtgagtac tccctctcaa aagcgggcat tacttctgcg ctaagattgt 60
cagtttccaa aaacgaggag gatttgatat tcacctggcc cg                    102

<210> 26
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
ctgttctcat cacatcatat caaggttata taccatcaat attgccacag atgttactta 60
gccttttaat atttctctaa tttagtgtat atgcaatgat agttctctga tttctgagat 120
tgagtttctc atgtgtaatg attatttaga gtttctcttt catctgttca aatttttgtc 180
tagttttatt ttttactgat ttgtaagact tctttttata atctgcatat tacaattctc 240
tttactgggg tgttgcaaat attttctgtc attctatggc ctgacttttc ttaatggttt 300
tttaatttta aaaataagtc ttaatattca tgcaatctaa ttaacaatct tttctttgtg 360
gttaggactt tgagtcataa gaaatttttc tctacactga agtcatgatg gcatgcttct 420
atattatttt ctaaaagatt taaagttttg ccttctccat ttagacttat aattcactgg 480
aatttttttg tgtgtatggt atgacatatg ggttcccttt tattttttac atataaatat 540
atttccctgt ttttctaaaa aagaaaaaga tcatcatttt cccattgtaa aatgccatat 600
ttttttcata ggtcacttac atatatcaat gggtctgttt ctgagctcta ctctatttta 660
tcagcctcac tgtctatccc cacacatctc atgctttgct ctaaatcttg atatttagtg 720
gaacattctt tcccattttg ttctacaaga atatttttgt tattgtcttt gggctttcta 780
tatacatttt gaaatgaggt tgacaagtta                                  810

<210> 27
<211> 202
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
ctgcccgggt ggcatccctg tgacccctcc ccagtgcctc tcctggccct ggaagttgcc 60
actccagtgc ccaccagcct tgtcctaata aaattaagtt gcatcatttt gtctgactag 120
gtgtccttct ataatattat ggggtggagg ggggtggtat ggagcaaggg gcccaagttg 180
ggaagaaacc tgtagggcct gc                                          202

<210> 28
<211> 68
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
aggcggtctt gagacggcgg atggtcgagg tgaggtgtgg caggcttgag atccagctgt 60
tggggtga                                                          68

<210> 29
<211> 129
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
cgctgttttg acctccatag tggacaccgg gaccgatcca gcctccgcgt ctcaggggag 60
atctcgttta gtgaaccgtc agatcctcac tctcttccgc atcgctgtct gcgagggcca 120
gctgttggg                                                         129

<210> 30
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
ttgatattca cctggcccga tctggccata cacttg                           36

<210> 31
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
cccaggtcca agtttaaacg cc                                          22

<210> 32
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
tctttgggct ttctatatac attttgaaat gaggttgaca agttacctag gaaaactgtc 60
ttcctgcccg ggtggca                                                77

<210> 33
<211> 1172
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
ctctggagac gacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca 60
ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt 120
caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg 180
ccaagtccgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag 240
tacatgacct tacgggactt tcctacttgg cagtacatct acgtattagt catcgctatt 300
accatgctga tgcggttttg gcagtacacc aatgggcgtg gatagcggtt tgactcacgg 360
ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa 420
cgggactttc caaaatgtcg taataacccc gccccgttga cgcaaatggg cggtaggcgt 480
gtacggtggg aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga 540
ggccatccac gctgttttga cctccatagt ggacaccggg accgatccag cctccgcgtc 600
tcaggggaga tctcgtttag tgaaccgtca gatcctcact ctcttccgca tcgctgtctg 660
cgagggccag ctgttgggct cgcggttgag gacaaactct tcgcggtctt tccagtactc 720
ttggatcgga aacccgtcgg cctccgaacg gtactccgcc accgagggac ctgagcgagt 780
ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 840
gtaggctgag caccgtggcg ggcggcagcg ggtggcggtc ggggttgttt ctggcggagg 900
tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gaggtgaggt 960
gtggcaggct tgagatccag ctgttggggt gagtactccc tctcaaaagc gggcattact 1020
tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt tgatattcac ctggcccgat 1080
ctggccatac acttgagtga caatgacatc cactttgcct ttctctccac aggtgtccac 1140
tcccaggtcc aagtttaaac gccgccacca tg                               1172

<210> 34
<211> 1043
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
actgttctca tcacatcata tcaaggttat ataccatcaa tattgccaca gatgttactt 60
agccttttaa tatttctcta atttagtgta tatgcaatga tagttctctg atttctgaga 120
ttgagtttct catgtgtaat gattatttag agtttctctt tcatctgttc aaatttttgt 180
ctagttttat tttttactga tttgtaagac ttctttttat aatctgcata ttacaattct 240
ctttactggg gtgttgcaaa tattttctgt cattctatgg cctgactttt cttaatggtt 300
ttttaatttt aaaaataagt cttaatattc atgcaatcta attaacaatc ttttctttgt 360
ggttaggact ttgagtcata agaaattttt ctctacactg aagtcatgat ggcatgcttc 420
tatattattt tctaaaagat ttaaagtttt gccttctcca tttagactta taattcactg 480
gaattttttt gtgtgtatgg tatgacatat gggttccctt ttatttttta catataaata 540
tatttccctg tttttctaaa aaagaaaaag atcatcattt tcccattgta aaatgccata 600
tttttttcat aggtcactta catatatcaa tgggtctgtt tctgagctct actctatttt 660
atcagcctca ctgtctatcc ccacacatct catgctttgc tctaaatctt gatatttagt 720
ggaacattct ttcccatttt gttctacaag aatatttttg ttattgtctt tgggctttct 780
atatacattt tgaaatgagg ttgacaagtt acctaggaaa actgtcttcc tgcccgggtg 840
gcatccctgt gacccctccc cagtgcctct cctggccctg gaagttgcca ctccagtgcc 900
caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg tgtccttcta 960
taatattatg gggtggaggg gggtggtatg gagcaagggg cccaagttgg gaagaaacct 1020
gtagggcctg cgaagacagt cag                                         1043

<210> 35
<211> 431
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
 1               5                  10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
                85                  90                  95      
Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr
        195                 200                 205             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
    210                 215                 220                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
225                 230                 235                 240 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                245                 250                 255     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
            260                 265                 270         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
        275                 280                 285             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
    290                 295                 300                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
305                 310                 315                 320 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
                325                 330                 335     
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
            340                 345                 350         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
        355                 360                 365             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
    370                 375                 380                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
385                 390                 395                 400 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
                405                 410                 415     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
            420                 425                 430     


<210> 36
<211> 1377
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc 60
acaggatcta gttccggaag tgataccggt agacctttcg tagagatgta cagtgaaatc 120
cccgaaatta tacacatgac tgaaggaagg gagctcgtca ttccctgccg ggttacgtca 180
cctaacatca ctgttacttt aaaaaagttt ccacttgaca ctttgatccc tgatggaaaa 240
cgcataatct gggacagtag aaagggcttc atcatatcaa atgcaacgta caaagaaata 300
gggcttctga cctgtgaagc aacagtcaat gggcatttgt ataagacaaa ctatctcaca 360
catcgacaaa ccaatacaat catagatgtg gttctgagtc cgtctcatgg aattgaacta 420
tctgttggag aaaagcttgt cttaaattgt acagcaagaa ctgaactaaa tgtggggatt 480
gacttcaact gggaataccc ttcttcgaag catcagcata agaaacttgt aaaccgagac 540
ctaaaaaccc agtctgggag tgagatgaag aaatttttga gcaccttaac tatagatggt 600
gtaacccgga gtgaccaagg attgtacacc tgtgcagcat ccagtgggct gatgaccaag 660
aagaacagca catttgtcag ggtccatgaa aaggacaaaa ctcacacatg cccaccgtgc 720
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 780
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 840
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 900
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 960
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1020
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1080
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc 1140
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1200
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag 1260
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1320
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga    1377

<210> 37
<211> 745
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser
 1               5                  10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Leu Ala Leu Gly Glu
            580                 585                 590         
Thr Thr Arg Pro Ala Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln
        595                 600                 605             
Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln
    610                 615                 620                 
Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro
625                 630                 635                 640 
Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile
                645                 650                 655     
Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser
            660                 665                 670         
Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val
        675                 680                 685             
Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp
    690                 695                 700                 
Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val
705                 710                 715                 720 
Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile
                725                 730                 735     
Gly Thr Arg Tyr Leu Thr Arg Asn Leu
            740                 745 


<210> 38
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His
 1               5                  10                  15      
Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu
            20                  25                  30          
Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser
        35                  40                  45              
Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser
    50                  55                  60                  
Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys
65                  70                  75                  80  
Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr
                85                  90                  95      
Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala
            100                 105                 110         
Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly
        115                 120                 125             
Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile
    130                 135                 140                 
Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro
145                 150                 155                 160 
Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly
                165                 170                 175     
Asn Leu Ala Leu Gly Glu Thr Thr Arg Pro Ala Arg Gln Ala Ala Thr
            180                 185                 190         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp
        195                 200                 205             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr
    210                 215                 220                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys
225                 230                 235                 240 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn
                245                 250 


<210> 39
<211> 3916
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg 60
tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag 120
gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtact ctggagacga 180
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 240
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 300
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 360
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 420
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catgctgatg 480
cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt 540
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 600
aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag 660
gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagagg ccatccacgc 720
tgttttgacc tccatagtgg acaccgggac cgatccagcc tccgcgtctc aggggagatc 780
tcgtttagtg aaccgtcaga tcctcactct cttccgcatc gctgtctgcg agggccagct 840
gttgggctcg cggttgagga caaactcttc gcggtctttc cagtactctt ggatcggaaa 900
cccgtcggcc tccgaacggt actccgccac cgagggacct gagcgagtcc gcatcgaccg 960
gatcggaaaa cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca 1020
ccgtggcggg cggcagcggg tggcggtcgg ggttgtttct ggcggaggtg ctgctgatga 1080
tgtaattaaa gtaggcggtc ttgagacggc ggatggtcga ggtgaggtgt ggcaggcttg 1140
agatccagct gttggggtga gtactccctc tcaaaagcgg gcattacttc tgcgctaaga 1200
ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgatct ggccatacac 1260
ttgagtgaca atgacatcca ctttgccttt ctctccacag gtgtccactc ccaggtccaa 1320
gtttaaacgc cgccaccatg gtgtcatact gggatactgg agtcttgctt tgtgccctgc 1380
tgtcctgcct cctcctgact ggctccagct cgggctcaga taccggtcgc cccttcgtgg 1440
agatgtactc cgagatcccg gaaattatcc acatgactga ggggcgcgaa cttgtgatcc 1500
cctgccgggt caccagcccg aacattactg tgactttgaa gaagttcccc ctggacaccc 1560
tgattccgga tgggaagaga attatctggg attcacggaa gggattcatc atcagcaacg 1620
cgacctacaa ggaaattggc ctcctcactt gcgaagccac tgtgaacgga cacttgtaca 1680
agaccaacta cctgacccac cgccagacca acaccatcat cgacgtcgtc ctgtcccctt 1740
cgcacgggat cgagctctcg gtgggagaga agttggtgct taactgcacc gcccggacgg 1800
aactgaatgt gggaatcgac ttcaactggg aatacccgtc cagcaagcat cagcataaga 1860
agctggtgaa ccgggacctc aagactcagt ccggcagcga aatgaagaag ttcctgtcga 1920
ccctcactat tgacggagtg accagatccg accagggcct ctacacttgc gccgcttcca 1980
gcggactcat gaccaagaag aacagcactt tcgtgagggt gcatgagaag gacaagaccc 2040
acacgtgtcc gccgtgccca gccccagagc tgctgggagg cccttccgtg ttcctgtttc 2100
cgcccaagcc aaaggatacc ctgatgatct caaggacccc tgaggtcaca tgcgtcgtgg 2160
tggatgtgtc gcacgaggac cctgaagtca aattcaattg gtatgtggac ggagtggaag 2220
tccacaacgc gaaaaccaag ccgagagaag aacagtacaa ttccacctac cgggtggtgt 2280
cggtgctgac tgtgctgcac caggactggc tcaacggaaa ggagtacaag tgcaaggtgt 2340
ccaacaaggc tctgcccgca cctattgaaa agaccatctc caaggccaag ggtcaacctc 2400
gcgagcctca ggtgtacact ctgcctccaa gccgggacga actgactaag aaccaagtct 2460
ctctgacctg tttggtgaag ggcttctacc cgtcagacat cgcagtggag tgggagtcaa 2520
acggtcagcc ggagaacaac tacaaaacaa ccccccccgt gctggactcc gacggctcct 2580
tcttcctgta ctccaagctt accgtggata agagccgctg gcaacagggc aacgtgtttt 2640
cctgctccgt catgcacgaa gccctgcaca accattatac ccagaagtcc ctgtcgctgt 2700
cccccgggaa atagtgactg ttctcatcac atcatatcaa ggttatatac catcaatatt 2760
gccacagatg ttacttagcc ttttaatatt tctctaattt agtgtatatg caatgatagt 2820
tctctgattt ctgagattga gtttctcatg tgtaatgatt atttagagtt tctctttcat 2880
ctgttcaaat ttttgtctag ttttattttt tactgatttg taagacttct ttttataatc 2940
tgcatattac aattctcttt actggggtgt tgcaaatatt ttctgtcatt ctatggcctg 3000
acttttctta atggtttttt aattttaaaa ataagtctta atattcatgc aatctaatta 3060
acaatctttt ctttgtggtt aggactttga gtcataagaa atttttctct acactgaagt 3120
catgatggca tgcttctata ttattttcta aaagatttaa agttttgcct tctccattta 3180
gacttataat tcactggaat ttttttgtgt gtatggtatg acatatgggt tcccttttat 3240
tttttacata taaatatatt tccctgtttt tctaaaaaag aaaaagatca tcattttccc 3300
attgtaaaat gccatatttt tttcataggt cacttacata tatcaatggg tctgtttctg 3360
agctctactc tattttatca gcctcactgt ctatccccac acatctcatg ctttgctcta 3420
aatcttgata tttagtggaa cattctttcc cattttgttc tacaagaata tttttgttat 3480
tgtctttggg ctttctatat acattttgaa atgaggttga caagttacct aggaaaactg 3540
tcttcctgcc cgggtggcat ccctgtgacc cctccccagt gcctctcctg gccctggaag 3600
ttgccactcc agtgcccacc agccttgtcc taataaaatt aagttgcatc attttgtctg 3660
actaggtgtc cttctataat attatggggt ggaggggggt ggtatggagc aaggggccca 3720
agttgggaag aaacctgtag ggcctgcgta cgtagataag tagcatggcg ggttaatcat 3780
taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct 3840
cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt 3900
gagcgagcga gcgcgc                                                 3916

<210> 40
<211> 1377
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
atggtgtcat actgggatac tggagtcttg ctttgtgccc tgctgtcctg cctcctcctg 60
actggctcca gctcgggctc agataccggt cgccccttcg tggagatgta ctccgagatc 120
ccggaaatta tccacatgac tgaggggcgc gaacttgtga tcccctgccg ggtcaccagc 180
ccgaacatta ctgtgacttt gaagaagttc cccctggaca ccctgattcc ggatgggaag 240
agaattatct gggattcacg gaagggattc atcatcagca acgcgaccta caaggaaatt 300
ggcctcctca cttgcgaagc cactgtgaac ggacacttgt acaagaccaa ctacctgacc 360
caccgccaga ccaacaccat catcgacgtc gtcctgtccc cttcgcacgg gatcgagctc 420
tcggtgggag agaagttggt gcttaactgc accgcccgga cggaactgaa tgtgggaatc 480
gacttcaact gggaataccc gtccagcaag catcagcata agaagctggt gaaccgggac 540
ctcaagactc agtccggcag cgaaatgaag aagttcctgt cgaccctcac tattgacgga 600
gtgaccagat ccgaccaggg cctctacact tgcgccgctt ccagcggact catgaccaag 660
aagaacagca ctttcgtgag ggtgcatgag aaggacaaga cccacacgtg tccgccgtgc 720
ccagccccag agctgctggg aggcccttcc gtgttcctgt ttccgcccaa gccaaaggat 780
accctgatga tctcaaggac ccctgaggtc acatgcgtcg tggtggatgt gtcgcacgag 840
gaccctgaag tcaaattcaa ttggtatgtg gacggagtgg aagtccacaa cgcgaaaacc 900
aagccgagag aagaacagta caattccacc taccgggtgg tgtcggtgct gactgtgctg 960
caccaggact ggctcaacgg aaaggagtac aagtgcaagg tgtccaacaa ggctctgccc 1020
gcacctattg aaaagaccat ctccaaggcc aagggtcaac ctcgcgagcc tcaggtgtac 1080
actctgcctc caagccggga cgaactgact aagaaccaag tctctctgac ctgtttggtg 1140
aagggcttct acccgtcaga catcgcagtg gagtgggagt caaacggtca gccggagaac 1200
aactacaaaa caaccccccc cgtgctggac tccgacggct ccttcttcct gtactccaag 1260
cttaccgtgg ataagagccg ctggcaacag ggcaacgtgt tttcctgctc cgtcatgcac 1320
gaagccctgc acaaccatta tacccagaag tccctgtcgc tgtcccccgg gaaatag    1377

<210> 41
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser
 1               5                  10                  15      
Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Asp Thr Gly Arg Pro
            20                  25                  30          
Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu
        35                  40                  45              
Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr
    50                  55                  60                  
Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys
65                  70                  75                  80  
Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr
                85                  90                  95      
Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His
            100                 105                 110         
Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile
        115                 120                 125             
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
    130                 135                 140                 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
145                 150                 155                 160 
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
                165                 170                 175     
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
            180                 185                 190         
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu
        195                 200                 205             
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
    210                 215                 220                 
Phe Val Arg Val His Glu Lys Asp Lys Thr His Thr Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                245                 250                 255     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            260                 265                 270         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        275                 280                 285             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    290                 295                 300                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
305                 310                 315                 320 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                325                 330                 335     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            340                 345                 350         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        355                 360                 365             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    370                 375                 380                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
385                 390                 395                 400 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                405                 410                 415     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            420                 425                 430         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        435                 440                 445             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455             

