                         SEQUENCE LISTING

<110>  Avilar Therapeutics, Inc.
       Wiles, Jason Allan
 
<120>  POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF 
       IMMUNOGLOBULINS AND OTHER PROTEINS

<130>  19121-007WO1

<150>  US 63183450
<151>  2021-05-03

<150>  US 63228067
<151>  2021-07-31

<150>  US 63293447
<151>  2021-12-23

<150>  US 63331592
<151>  2022-04-15

<160>  360   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  synthetic construct

<400>  1

Met Leu Lys Lys Ile Glu 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  2

His Met Val Cys Leu Ala Tyr Arg Gly Arg Pro Val Cys Phe Ala Leu 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  3

His Met Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe Ser Leu 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  4

His Gln Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe Ser Thr 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  5

Gln Met Arg Cys Leu Ser Tyr Lys Gly Arg Arg Val Cys Leu Trp Leu 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  6

Lys Arg Leu Cys Leu Gln Tyr Lys Gly Ser Lys Val Cys Phe Arg Leu 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  7

Arg Met Arg Cys Leu Thr Tyr Arg Gly Arg Arg Val Cys Leu Glu Leu 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  8

Ser Met Arg Cys Leu Gln Tyr Arg Gly Ser Arg Val Cys Leu Thr Leu 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  9

His Leu Arg Cys Leu Arg Tyr Lys Gly Thr Arg Val Cys Phe Ser Leu 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  10

His Val Arg Cys Leu Ser Tyr Lys Gly Arg Glu Val Cys Val Gln Leu 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  11

Pro Arg Met Cys Leu Phe Ile Tyr Lys Gly Arg Arg Val Cys Ile Pro 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  12

His Met Arg Cys Leu His Tyr Lys Gly Arg Arg Val Cys Phe Leu Leu 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  13

His Lys Arg Cys Leu His Tyr Arg Gly Arg Met Val Cys Phe Leu Ile 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  14

Gln Lys Arg Cys Leu Lys Tyr Lys Gly Ser Arg Val Cys Phe Phe Leu 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  15

His Val Arg Cys Leu Arg Tyr Arg Gly Lys Asn Val Cys Phe Leu Leu 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  16

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  17

Arg Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  18

His Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  19

Ser Met Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  20

Ser Ala Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  21

Ser Asp Val Cys Leu Asn Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  22

Ser Asp Val Cys Leu His Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  23

Ser Asp Val Cys Leu Ala Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  24

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Ala Val 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  25

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Leu 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  26

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Ala 
1               5                   10                  15      


<210>  27
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  27

His Met Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe 
1               5                   10                  


<210>  28
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  28

His Met Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe Ser 
1               5                   10                  15  


<210>  29
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  29

His Gln Val Cys Leu Ser Tyr Arg Gly Gln Pro Val Cys Phe Ser Leu 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  30

His Gln Val Cys Leu Ser Tyr Arg Gly Arg Pro Thr Cys Phe Ser Leu 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  31

His Gln Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Tyr Ser Leu 
1               5                   10                  15      


<210>  32
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  32

His Gln Val Cys Leu Ser Tyr Arg Gly Gln Pro Val Cys Phe Ser Thr 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  33

His Gln Val Cys Leu Ser Tyr Arg Gly Arg Pro Thr Cys Phe Ser Thr 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  34

His Gln Val Cys Leu Ser Tyr Arg Gly Gln Pro Thr Cys Phe Ser Thr 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (3)..(7)

<220>
<221>  BINDING
<222>  (7)..(12)

<220>
<221>  BINDING
<222>  (11)..(16)

<400>  35

Arg Thr Tyr Arg Thr Tyr Lys Arg Thr Tyr Lys Lys Gly Arg Thr Tyr 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(16)
<223>  D-Amino Acids

<220>
<221>  BINDING
<222>  (3)..(7)

<220>
<221>  BINDING
<222>  (7)..(12)

<220>
<221>  BINDING
<222>  (11)..(16)

<400>  36

Arg Thr Tyr Arg Thr Tyr Lys Arg Thr Tyr Lys Lys Gly Arg Thr Tyr 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(16)
<223>  D-Amino Acids

<220>
<221>  SITE
<222>  (1)..(1)
<223>  Phenylacetic acid

<220>
<221>  BINDING
<222>  (3)..(7)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Phenylacetic acid

<220>
<221>  BINDING
<222>  (7)..(12)

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Phenylacetic acid

<220>
<221>  BINDING
<222>  (11)..(16)

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Phenylacetic acid

<400>  37

Arg Thr Tyr Arg Thr Tyr Lys Arg Thr Tyr Lys Lys Gly Arg Thr Tyr 
1               5                   10                  15      


<210>  38
<211>  10
<212>  PRT
<213>  synthetic construct

<400>  38

Thr Trp Lys Thr Ser Arg Ile Ser Ile Phe 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  synthetic construct

<400>  39

Phe Gly Arg Leu Val Ser Ser Ile Arg Tyr 
1               5                   10  


<210>  40
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  40

Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  41
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  41

Asp Ser Ala Trp His Leu Gly Glu Leu Trp Ser Thr 
1               5                   10          


<210>  42
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  42

Asp Cys His Lys Arg Ser Phe Trp Ala Asp Asn Cys Thr 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  43

Asp Cys Arg Thr Gln Phe Arg Pro Asn Gln Thr Cys Thr 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  44

Asp Cys Gln Leu Cys Asp Phe Trp Arg Thr Arg Cys Thr 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  45

Asp Cys Phe Glu Asp Phe Asn Glu Gln Arg Thr Cys Thr 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  46

Asp Cys Leu Ala Lys Phe Leu Lys Gly Lys Asp Cys Thr 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  47

Asp Cys Trp His Arg Arg Thr His Lys Thr Phe Cys Thr 
1               5                   10              


<210>  48
<211>  11
<212>  PRT
<213>  synthetic construct

<400>  48

Asp Cys Arg Thr Ile Gln Thr Arg Ser Cys Thr 
1               5                   10      


<210>  49
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  49

Asp Cys Ile Lys Leu Ala Gln Leu His Ser Val Cys Thr 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  50

Asp Cys Trp Arg His Arg Asn Ala Thr Glu Trp Cys Thr 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  51

Asp Cys Gln Asn Trp Ile Lys Asp Val His Lys Cys Thr 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  52

Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  53

Asp Cys Ala Phe His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  54

Asp Cys Ala Tyr His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  55
<211>  11
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (1)..(11)

<220>
<221>  SITE
<222>  (11)..(11)
<223>  D-Phenylalanine

<400>  55

Pro Ala Trp His Leu Gly Glu Leu Val Trp Pro 
1               5                   10      


<210>  56
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (1)..(15)

<220>
<221>  BINDING
<222>  (3)..(13)

<220>
<221>  SITE
<222>  (15)..(15)
<223>  D-Amino Acid

<400>  56

Pro Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Pro 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (1)..(15)

<220>
<221>  BINDING
<222>  (3)..(13)

<400>  57

Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15  


<210>  58
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  58

Glu Pro Ile His Arg Ser Thr Leu Thr Ala Leu Leu 
1               5                   10          


<210>  59
<211>  4
<212>  PRT
<213>  synthetic construct

<400>  59

Ala Pro Ala Arg 
1               


<210>  60
<211>  6
<212>  PRT
<213>  synthetic construct


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeated twice

<220>
<221>  BINDING
<222>  (1)..(1)

<220>
<221>  BINDING
<222>  (4)..(5)

<400>  60

Cys Phe His His Lys Gly 
1               5       


<210>  61
<211>  6
<212>  PRT
<213>  synthetic construct

<400>  61

His Trp Arg Gly Trp Val 
1               5       


<210>  62
<211>  6
<212>  PRT
<213>  synthetic construct

<400>  62

His Tyr Phe Lys Phe Asp 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  synthetic construct

<400>  63

His Phe Arg Arg His Leu 
1               5       


<210>  64
<211>  6
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (3)..(3)
<223>  Citrulline

<400>  64

His Trp Xaa Gly Trp Val 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (2)..(2)
<223>  Citrulline

<220>
<221>  SITE
<222>  (3)..(3)
<223>  Citrulline

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<400>  65

His Trp Xaa Gly Trp Val 
1               5       


<210>  66
<211>  4
<212>  PRT
<213>  synthetic construct


<220>
<221>  REPEAT
<222>  (1)..(1)
<223>  repeated twice

<220>
<221>  BINDING
<222>  (1)..(2)

<400>  66

Asp Ala Ala Gly 
1               


<210>  67
<211>  4
<212>  PRT
<213>  synthetic construct

<400>  67

Asp Ala Ala Gly 
1               


<210>  68
<211>  8
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  (Nalpha-Ac)-S(A)

<220>
<221>  BINDING
<222>  (1)..(8)

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Lact-E

<400>  68

Xaa Arg Trp His Tyr Phe Lys Xaa 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (1)..(8)

<220>
<221>  SITE
<222>  (1)..(1)
<223>  (Nalpha-Ac)-Dap(A)

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Lact-E

<400>  69

Xaa Arg Trp His Tyr Phe Lys Xaa 
1               5               


<210>  70
<211>  7
<212>  PRT
<213>  synthetic construct


<220>
<221>  BINDING
<222>  (1)..(7)

<220>
<221>  SITE
<222>  (1)..(1)
<223>  Link M

<400>  70

Xaa Trp Phe Arg His Tyr Lys 
1               5           


<210>  71
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  71

Asn Lys Phe Arg Gly Lys Tyr Lys 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  72

Asn Ala Arg Lys Phe Tyr Lys Gly 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  73

Phe Tyr Trp His Cys Leu Asp Glu 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  74

Phe Tyr Cys His Trp Ala Leu Glu 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  75

Phe Tyr Cys His Thr Ile Asp Glu 
1               5               


<210>  76
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  76

Phe Tyr Trp His Cys Leu Asp Glu Phe Tyr Cys His Thr Ile Asp Glu 
1               5                   10                  15      


<210>  77
<211>  4
<212>  PRT
<213>  synthetic construct

<400>  77

Arg Arg Gly Trp 
1               


<210>  78
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  78

Lys His Arg Phe Asn Lys Asp 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  79

Cys Pro Ser Thr His Trp Lys 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  80

Asn Val Gln Tyr Phe Ala Val 
1               5           


<210>  81
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  81

Ala Ser His Thr Gln Lys Ser 
1               5           


<210>  82
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  82

Gln Pro Gln Met Ser His Met 
1               5           


<210>  83
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  83

Thr Asn Ile Glu Ser Leu Lys 
1               5           


<210>  84
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  84

Asn Cys His Lys Cys Trp Asn 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  85

Ser His Leu Ser Lys Asn Phe 
1               5           


<210>  86
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  86

Phe Asp Leu Leu Glu His Phe Tyr 
1               5               


<210>  87
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  87

Asp Leu Leu His His Phe Asp Tyr Phe 
1               5                   


<210>  88
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  88

Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys 
1               5                   10              


<210>  89
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  89

Ser Val Leu Thr Leu Glu Asn Cys Lys 
1               5                   


<210>  90
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  90

Ser Val Leu Thr Leu Glu Asn Cys 
1               5               


<210>  91
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  91

Ser Val Leu Thr Leu Asp Asn Cys Lys 
1               5                   


<210>  92
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  92

Ser Val Leu Thr Glu Glu Asn Cys 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  93

Ser Val Leu Thr Glu Glu Asn Ser 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  94

Ser Val Leu Thr Asp Glu Asn Cys 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  95

Ser Val Leu Thr Asp Glu Asn Ser 
1               5               


<210>  96
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  96

Pro Ile Gln Ser Glu Ser Leu Lys Lys 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  97

Val Ile Asp Ser Glu Ser Leu Lys Lys 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  98

Pro Ile Asp Ser Glu Ser Leu Lys Lys 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  99

Val Ile Gln Ser Glu Ser Leu Lys Lys 
1               5                   


<210>  100
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  100

Pro Ile Glu Ser Glu Ser Pro Glu Gly Lys Pro Glu Gly Ser Val Leu 
1               5                   10                  15      


Thr Glu Glu Asn Cys 
            20      


<210>  101
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  101

Val Ile Gln Ser Glu Ser Pro Glu Gly Lys Pro Glu Gly Ser Val Leu 
1               5                   10                  15      


Thr Leu Glu Asn Cys 
            20      


<210>  102
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  102

Val Ile Gln Ser Glu Ser Pro Glu Gly Lys Pro Glu Gly Ser Val Leu 
1               5                   10                  15      


Thr Glu Glu Asn Cys 
            20      


<210>  103
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  103

Pro Ile Asp Asp Glu Ser Pro Glu Gly Lys Pro Glu Gly Ser Val Leu 
1               5                   10                  15      


Thr Leu Glu Asn Cys 
            20      


<210>  104
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  104

Pro Ile Asp Asp Glu Ser Pro Glu Gly Lys Pro Glu Gly Ser Val Leu 
1               5                   10                  15      


Thr Glu Glu Asn Cys 
            20      


<210>  105
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  105

Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  106
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  106

Pro Ile Gln Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  107
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  107

Val Ile Glu Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  108
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  108

Val Ile Asp Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  109
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  109

Pro Ile Glu Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  110
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  110

Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  111
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  111

Pro Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  112
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  112

Val Ile Glu Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  113
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  113

Val Ile Asp Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  114
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  114

Pro Ile Glu Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Cys 
            


<210>  115
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  115

Pro Ile Gln Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  116
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  116

Val Ile Glu Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  117
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  117

Val Ile Asp Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  118
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  118

Pro Ile Glu Ser Glu Ser Leu Lys Lys Cys Lys Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  119
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  119

Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  120
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  120

Pro Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  121
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  121

Val Ile Glu Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  122
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  122

Val Ile Asp Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  123
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  123

Pro Ile Glu Ser Glu Ser Leu Lys Lys Cys Ile Gln Ala Gly Lys Leu 
1               5                   10                  15      


Glu Asn Lys 
            


<210>  124
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  124

Pro Ile Glu Ser Glu Ser Gly Ser Val Leu Thr Leu Glu Asn Cys Lys 
1               5                   10                  15      


<210>  125
<211>  17
<212>  PRT
<213>  synthetic construct

<400>  125

Pro Ile Glu Ser Glu Ser Gly Gly Ser Val Leu Thr Leu Glu Asn Cys 
1               5                   10                  15      


Lys 
    


<210>  126
<211>  18
<212>  PRT
<213>  synthetic construct

<400>  126

Pro Ile Glu Ser Glu Ser Gly Gly Gly Ser Val Leu Thr Leu Glu Asn 
1               5                   10                  15      


Cys Lys 
        


<210>  127
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  127

Pro Ile Glu Ser Glu Ser Gly Gly Gly Gly Ser Val Leu Thr Leu Glu 
1               5                   10                  15      


Asn Cys Lys 
            


<210>  128
<211>  20
<212>  PRT
<213>  synthetic construct

<400>  128

Pro Ile Glu Ser Glu Ser Gly Gly Gly Gly Gly Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys Lys 
            20  


<210>  129
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  129

Val Ile Gln Ser Glu Ser Gly Ser Val Leu Thr Leu Glu Asn Cys Lys 
1               5                   10                  15      


<210>  130
<211>  17
<212>  PRT
<213>  synthetic construct

<400>  130

Val Ile Gln Ser Glu Ser Gly Gly Ser Val Leu Thr Leu Glu Asn Cys 
1               5                   10                  15      


Lys 
    


<210>  131
<211>  18
<212>  PRT
<213>  synthetic construct

<400>  131

Val Ile Gln Ser Glu Ser Gly Gly Gly Ser Val Leu Thr Leu Glu Asn 
1               5                   10                  15      


Cys Lys 
        


<210>  132
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  132

Val Ile Gln Ser Glu Ser Gly Gly Gly Gly Ser Val Leu Thr Leu Glu 
1               5                   10                  15      


Asn Cys Lys 
            


<210>  133
<211>  20
<212>  PRT
<213>  synthetic construct

<400>  133

Val Ile Gln Ser Glu Ser Gly Gly Gly Gly Gly Ser Val Leu Thr Leu 
1               5                   10                  15      


Glu Asn Cys Lys 
            20  


<210>  134
<211>  28
<212>  PRT
<213>  synthetic construct

<400>  134

Lys Gly Cys Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Ser Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys 
            20                  25              


<210>  135
<211>  21
<212>  PRT
<213>  synthetic construct

<400>  135

Leu Lys Lys Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn 
1               5                   10                  15      


Cys Lys Gln Ala Asn 
            20      


<210>  136
<211>  22
<212>  PRT
<213>  synthetic construct

<400>  136

Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys 
1               5                   10                  15      


Cys Ile Gln Ala Gly Lys 
            20          


<210>  137
<211>  28
<212>  PRT
<213>  synthetic construct

<400>  137

Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys Ile Gln 
1               5                   10                  15      


Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys 
            20                  25              


<210>  138
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  138

Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys Cys 
1               5                   10              


<210>  139
<211>  10
<212>  PRT
<213>  synthetic construct

<400>  139

Trp Ser Val Leu Thr Leu Glu Asn Cys Lys 
1               5                   10  


<210>  140
<211>  31
<212>  PRT
<213>  synthetic construct

<400>  140

Trp Gln Asp Lys Gly Ile Phe Val Ile Gln Ser Glu Ser Leu Lys Lys 
1               5                   10                  15      


Cys Ile Gln Ala Gly Lys Ser Val Leu Thr Leu Glu Asn Cys Lys 
            20                  25                  30      


<210>  141
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  141

Tyr Asp Trp Ile Pro Ser Ser Ala Trp 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  142

Ala Gly Ala Ile Trp Gln Arg Asp Trp 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  143

Ala Gly Ala Ile Trp Gln Lys Asp Trp 
1               5                   


<210>  144
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  144

Val Ile Gln Ser Glu Ser Leu Lys 
1               5               


<210>  145
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  145

Pro Ile Gln Ser Glu Ser Leu Lys 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  synthetic construct

<400>  146

Pro Ile Glu Ser Glu Ser Leu Lys 
1               5               


<210>  147
<211>  9
<212>  PRT
<213>  synthetic construct

<400>  147

Ser Val Leu Thr Glu Glu Asn Cys Lys 
1               5                   


<210>  148
<211>  8
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (5)..(5)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Any Naturally-Occurring Amino Acid

<400>  148

Ser Val Leu Thr Xaa Glu Asn Xaa 
1               5               


<210>  149
<211>  6
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (3)..(3)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (6)..(6)
<223>  Any Naturally-Occurring Amino Acid

<400>  149

Xaa Ile Xaa Xaa Glu Xaa 
1               5       


<210>  150
<211>  5
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Any Naturally-Occurring Amino Acid

<400>  150

Xaa Glu Asn Xaa Lys 
1               5   


<210>  151
<211>  9
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (5)..(5)
<223>  Any Naturally-Occurring Amino Acid

<400>  151

Ser Val Leu Thr Xaa Glu Asn Cys Lys 
1               5                   


<210>  152
<211>  8
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (3)..(3)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Any Naturally-Occurring Amino Acid

<220>
<221>  SITE
<222>  (6)..(6)
<223>  Any Naturally-Occurring Amino Acid

<400>  152

Xaa Ile Xaa Xaa Glu Xaa Leu Lys 
1               5               


<210>  153
<211>  14
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  D-Amino Acid

<220>
<221>  DISULFID
<222>  (3)..(13)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  METHYLATION

<400>  153

Tyr Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10                  


<210>  154
<211>  26
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  154

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr Ala Gly Met 
1               5                   10                  15      


Ala Asn Leu Thr Ser His Ala Ser Ala Ile 
            20                  25      


<210>  155
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISUFLID
<222>  (2)..(12)

<400>  155

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  156
<211>  11
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(11)

<400>  156

Cys Val Val Gln Asp Trp Gly His His Ala Cys 
1               5                   10      


<210>  157
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  157

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  158
<211>  12
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISFULFID
<222>  (1)..(11)

<400>  158

Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10          


<210>  159
<211>  11
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISFULFID
<222>  (1)..(11)

<400>  159

Cys Val Val Gln Asp Trp Gly His His Arg Cys 
1               5                   10      


<210>  160
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  160

Ile Cys Val Val Gly Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  161
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  161

Ile Cys Val Val Gln Pro Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  162
<211>  17
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (6)..(16)

<400>  162

Lys Tyr Ser Ser Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys 
1               5                   10                  15      


Thr 
    


<210>  163
<211>  27
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  163

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr Ala Gly His 
1               5                   10                  15      


Met Ala Asn Leu Thr Ser His Ala Ser Ala Lys 
            20                  25          


<210>  164
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<400>  164

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  165
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  vIle

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Methylation

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Methylation

<400>  165

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  166
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  vIle

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  METHYLATION

<400>  166

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  167
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  167

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  168
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  METHYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  METHYLATION

<400>  168

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  169
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  METHYLATION

<400>  169

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  170
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<400>  170

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  171
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  171

Xaa Cys Val Xaa Gln Asp Trp Gly Xaa Xaa Xaa Cys Thr 
1               5                   10              


<210>  172
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  172

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  173
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  173

Ile Cys Val Val Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  174
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  174

Ile Cys Val Thr Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  175
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  175

Ile Cys Val Ser Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  176
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  176

Ile Cys Val His Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  177
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  177

Ile Cys Val Phe Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  178
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  178

Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  179
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  179

Ile Cys Val Trp Gln Asp Trp Gly Trp His Arg Cys Thr 
1               5                   10              


<210>  180
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  180

Ile Cys Val Trp Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  181
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  181

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  182
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  182

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  183
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  SITE
<222>  (10)..(10)
<223>  D-Amino Acid

<400>  183

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  184
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  SITE
<222>  (9)..(9)
<223>  D-Amino Acid

<400>  184

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  185
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  D-Amino Acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  185

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  186
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  SITE
<222>  (13)..(13)
<223>  D-Amino Acid

<400>  186

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  187
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  187

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  188
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  188

Trp Cys Val Trp Gln Asp Trp Gly Thr Asn Arg Cys Trp 
1               5                   10              


<210>  189
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  189

Asp Cys Val Trp Gln Asp Trp Gly Thr Asn Lys Cys Trp 
1               5                   10              


<210>  190
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  190

Gln Cys Val Trp Gln Asp Trp Gly Gln Asn Gln Cys Trp 
1               5                   10              


<210>  191
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  191

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Trp 
1               5                   10              


<210>  192
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  192

Trp Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  193
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<400>  193

Trp Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Trp 
1               5                   10              


<210>  194
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (2)..(12)

<220>
<221>  SITE
<222>  (12)..(12)
<223>  Homocysteine

<400>  194

Ile Ala Val Trp Gln Asp Trp Gly Ala His Arg Xaa Thr 
1               5                   10              


<210>  195
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  METHYLATION

<400>  195

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile 
1               5                   10              


<210>  196
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (2)..(12)

<220>
<221>  SITE
<222>  (12)..(12)
<223>  HOMOCYSTEINE

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  METHYLATION

<400>  196

Ile Ala Val Trp Gln Asp Trp Gly Ala His Arg Xaa Ile 
1               5                   10              


<210>  197
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5fTrp

<400>  197

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  198
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  m5Trp

<400>  198

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  199
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Naphthylalanine

<400>  199

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  200
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5fTrp

<400>  200

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  201
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  m5Trp

<400>  201

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  202
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  METHYLATION

<400>  202

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  203
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  203

Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  204
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  204

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  205
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  205

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  206
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (13)..(13)
<223>  D-Amino Acid

<400>  206

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  207
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Naphthylalanine

<400>  207

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  208
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Naphthylalanine

<400>  208

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  209
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Naphthylalanine

<400>  209

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  210
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Lysoalanine

<400>  210

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  211
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  MOD_RES

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Lysoalanine

<400>  211

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  212
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  htQ

<400>  212

Ile Cys Val Asp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  213
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Boa

<400>  213

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  214
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  4-Benzoylphenylalanine

<400>  214

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  215
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  L-3-Benzothienylalanine

<400>  215

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  216
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  SITE
<222>  (4)..(4)
<223>  L-3-Benzothienylalanine

<400>  216

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  217
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Abu

<400>  217

Ile Cys Val Trp Gln Asp Trp Gly Xaa His Arg Cys Thr 
1               5                   10              


<210>  218
<211>  16
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  H-Gly

<400>  218

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Ala Asn 
1               5                   10                  15      


<210>  219
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5fTrp

<400>  219

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  220
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  m5Trp

<400>  220

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  221
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<400>  221

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  222
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5fTrp

<400>  222

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  223
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5fTrp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5fTrp

<400>  223

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  224
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  m5Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  m5Trp

<400>  224

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  225
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5fTrp

<400>  225

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  226
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  H-Gly

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  6fTrp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  6fTrp

<400>  226

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  227
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-formylTrp

<400>  227

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  228
<211>  13
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methyoxyTrp

<400>  228

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  229
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  H-Gly

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  5fTrp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5fTrp

<400>  229

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  230
<211>  7
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  230

Ala Glu Ala Lys Ala Lys Ala 
1               5           


<210>  231
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  231

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  232
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  232

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  233
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  233

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  234
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  234

Arg Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  235
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  235

Ile Arg Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  236
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  236

Ile Ala Arg Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  237
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  237

Ile Ala Leu Ile Arg Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  238
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  238

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Arg Glu Arg Ala Ala 
1               5                   10                  15  


<210>  239
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  239

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Arg Arg Ala Ala 
1               5                   10                  15  


<210>  240
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  240

Ile Glu Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  241
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  241

Ile Ala Glu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  242
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  242

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Glu Ala Ala 
1               5                   10                  15  


<210>  243
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  243

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Glu Ala 
1               5                   10                  15  


<210>  244
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  244

Ile Ala Leu Ile Leu Glu Glu Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  245
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  245

Ile Ala Leu Ile Leu Glu Pro Glu Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  246
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  246

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Ala Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  247
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(12)

<400>  247

Cys Glu Gly Pro Phe Gly Pro Arg His Asp Leu Thr Phe Cys Trp 
1               5                   10                  15  


<210>  248
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xb

<220>
<221>  DISULFID
<222>  (1)..(12)

<400>  248

Xaa Glu Gly Pro Phe Gly Pro Arg His Asp Leu Thr Phe Cys Trp 
1               5                   10                  15  


<210>  249
<211>  7
<212>  PRT
<213>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  249

Gln Tyr Tyr Pro Phe Ser Xaa 
1               5           


<210>  250
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  250

Asn Pro Phe Asn Leu Ala Arg 
1               5           


<210>  251
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  251

Gln Leu Gln Asp Met Thr Ser Ser Pro Phe Trp Leu 
1               5                   10          


<210>  252
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  252

Asn Pro Phe Val Ile Gly Arg Trp His Pro Pro His 
1               5                   10          


<210>  253
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  253

Ser Leu Ala Lys Phe Leu Asn Pro Phe Leu Tyr Arg 
1               5                   10          


<210>  254
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  254

Ala Ser Thr Pro Arg Phe Glu Pro Phe Gln Leu Asp 
1               5                   10          


<210>  255
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  255

Ser Leu His Ser Gln Pro Tyr Ser Pro Phe Met Leu 
1               5                   10          


<210>  256
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  256

Asn Ile Leu Ser Ser Trp Ser Ser Pro Phe Val Phe 
1               5                   10          


<210>  257
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  257

Asn Leu Pro Ser Ser Trp Thr Asn Pro Phe Tyr Leu 
1               5                   10          


<210>  258
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  258

Ser Pro Phe Met Leu His Pro 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  259

Pro Ser Pro Phe Met Leu Thr 
1               5           


<210>  260
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  260

Ile Gly Pro Phe His Leu His 
1               5           


<210>  261
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  261

Thr Asn Pro Phe Met Leu Asn 
1               5           


<210>  262
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  262

Asn Thr Thr Phe Leu Tyr Pro 
1               5           


<210>  263
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  263

Ser His Tyr Thr Gln Tyr Leu 
1               5           


<210>  264
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  264

Asn His His Pro Asn Tyr Trp 
1               5           


<210>  265
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  265

Val His Tyr Pro Leu Ser Trp 
1               5           


<210>  266
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  266

His His Leu Lys Tyr Ser Asp Thr Ser Pro Pro Ile 
1               5                   10          


<210>  267
<211>  13
<212>  PRT
<213>  synthetic construct

<400>  267

Ser His Met His Glu Arg Trp Asp Thr Ser Pro Pro Ile 
1               5                   10              


<210>  268
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  268

Ser His Met His Glu Arg Trp Asp Thr Ser Tyr Gln 
1               5                   10          


<210>  269
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  269

Ser His Ile His Ser Asn Ala Ala Trp Arg Ile Thr 
1               5                   10          


<210>  270
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  270

Trp His Tyr Pro His Trp Gln 
1               5           


<210>  271
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  271

Ser His Tyr Leu Tyr Thr Gln 
1               5           


<210>  272
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  272

Ala His Tyr Ser Phe Thr Gln 
1               5           


<210>  273
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  273

Thr His Tyr Pro Thr Phe Tyr 
1               5           


<210>  274
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  274

Glu His Asn Thr Ser Phe Trp 
1               5           


<210>  275
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  275

Asn His Tyr Lys Leu Thr Trp 
1               5           


<210>  276
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  276

Asn His Ser Pro Tyr Phe Gln 
1               5           


<210>  277
<211>  7
<212>  PRT
<213>  synthetic construct

<400>  277

Ser His Tyr Gln His Tyr Gln 
1               5           


<210>  278
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  278

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  279
<211>  10
<212>  PRT
<213>  synthetic construct

<400>  279

Trp Leu Gly Leu Gly Gly Gly Tyr Gly Trp 
1               5                   10  


<210>  280
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  280

Phe Tyr Gly Pro Phe Phe Leu Asn Asp Ser Leu Arg Gly Ile Trp 
1               5                   10                  15  


<210>  281
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  281

Leu Arg Phe Leu Asn Pro Phe Ser Leu Asp Gly Ser Gly Phe Trp 
1               5                   10                  15  


<210>  282
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  282

His Ser Pro Phe Cys Leu Gly Val Leu Glu Cys Phe Gly Leu Val 
1               5                   10                  15  


<210>  283
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  283

Thr Cys Gly Ala Phe Tyr Leu Tyr His Asp Pro Phe Ile Cys Gly 
1               5                   10                  15  


<210>  284
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  284

Met Gln His Cys Leu Ala Ser His Glu Leu Tyr Leu Pro Trp Cys 
1               5                   10                  15  


<210>  285
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  285

Phe Phe Val Phe Gly Ser Gly Asp Ala Phe Ala Phe Ser Asp Met 
1               5                   10                  15  


<210>  286
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  286

Pro Cys Val Ile Ile Asp Thr Gly Ser Ser Arg Trp Cys Tyr Leu 
1               5                   10                  15  


<210>  287
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  287

His Ser Pro Phe Cys Leu Gly Val Leu Glu Cys Phe Gly Leu Val 
1               5                   10                  15  


<210>  288
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  288

His Ala Ala Phe Glu Pro Arg Gly Asp Val Arg His Thr Leu Leu 
1               5                   10                  15  


<210>  289
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  289

Cys Arg Trp Asp Gly Ser Trp Gly Glu Val Arg Cys 
1               5                   10          


<210>  290
<211>  12
<212>  PRT
<213>  synthetic construct

<400>  290

Cys Tyr Trp Val Gly Thr Trp Gly Glu Ala Val Cys 
1               5                   10          


<210>  291
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  291

Arg Trp Phe Pro Cys Pro Asn Lys Glu Gly Cys Cys Ser Ile Ser Val 
1               5                   10                  15      


<210>  292
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  292

Arg Ser Thr Tyr Cys Asn Lys Asn Lys Asp Ser Cys His Ile Pro Glu 
1               5                   10                  15      


<210>  293
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  293

Gln Pro Pro Gln Cys Ile Lys Asp Gly Gly Phe Val Ile Cys Arg Val 
1               5                   10                  15      


<210>  294
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  294

Lys Gly Lys Lys Cys Lys Pro Glu Glu His Pro Cys Asn Glu Pro Met 
1               5                   10                  15      


<210>  295
<211>  16
<212>  PRT
<213>  synthetic construct

<400>  295

Asn Lys Met Thr Cys Ser Asp Asp Gly Lys Leu Cys Trp Glu His Leu 
1               5                   10                  15      


<210>  296
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  296

Pro Leu Gly Arg Pro Cys Pro Thr Cys Pro Leu Ala Pro Ser 
1               5                   10                  


<210>  297
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  297

Gln Arg Met Arg Pro Cys Pro Ser Cys Pro Leu Ala Pro Trp 
1               5                   10                  


<210>  298
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  298

Trp Pro Ser Arg Pro Cys Pro Ser Cys Pro Glu Val Pro Pro 
1               5                   10                  


<210>  299
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  299

Ser Cys Thr Lys Asp Cys Pro Thr Cys Pro Leu Val Pro Val 
1               5                   10                  


<210>  300
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  300

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  301
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  301

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  302
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  302

Pro Ala Ile Ala Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  303
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  303

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Ala Ile Leu Leu 
            20                  25                  30  


<210>  304
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  304

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Ala Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  305
<211>  30
<212>  PRT
<213>  synthetic construct

<400>  305

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Ala Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  306
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  306

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  307
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  307

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  308
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  308

Pro Ala Ile Ala Gln Arg Ala Glu Ile Glu Ala Ala Ile Leu Leu 
1               5                   10                  15  


<210>  309
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  309

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  310
<211>  27
<212>  PRT
<213>  synthetic construct

<400>  310

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Asn Thr Ser 
1               5                   10                  15      


Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25          


<210>  311
<211>  23
<212>  PRT
<213>  synthetic construct

<400>  311

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Ser Gly Thr Thr Glu 
1               5                   10                  15      


Ile Glu Ala Cys Ile Leu Leu 
            20              


<210>  312
<211>  19
<212>  PRT
<213>  synthetic construct

<400>  312

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Thr Glu Ile Glu Ala Cys 
1               5                   10                  15      


Ile Leu Leu 
            


<210>  313
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  313

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  314
<211>  29
<212>  PRT
<213>  synthetic construct

<400>  314

Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn 
1               5                   10                  15      


Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  


<210>  315
<211>  28
<212>  PRT
<213>  synthetic construct

<400>  315

Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn Thr 
1               5                   10                  15      


Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25              


<210>  316
<211>  27
<212>  PRT
<213>  synthetic construct

<400>  316

Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn Thr Ser 
1               5                   10                  15      


Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25          


<210>  317
<211>  29
<212>  PRT
<213>  synthetic construct

<400>  317

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu 
            20                  25                  


<210>  318
<211>  28
<212>  PRT
<213>  synthetic construct

<400>  318

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile 
            20                  25              


<210>  319
<211>  27
<212>  PRT
<213>  synthetic construct

<400>  319

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys 
            20                  25          


<210>  320
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  320

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  321
<211>  30
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  321

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  322
<211>  30
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  322

Pro Ala Ile Ala Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  323
<211>  30
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  323

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Ala Ile Leu Leu 
            20                  25                  30  


<210>  324
<211>  30
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  324

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Ala Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  325
<211>  30
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  325

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Ala Ala Cys Ile Leu Leu 
            20                  25                  30  


<210>  326
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  326

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  327
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  327

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  328
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  328

Pro Ala Ile Ala Gln Arg Ala Glu Ile Glu Ala Ala Ile Leu Leu 
1               5                   10                  15  


<210>  329
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  329

Ile Ala Leu Ile Leu Glu Pro Ile Cys Cys Gln Glu Arg Ala Ala 
1               5                   10                  15  


<210>  330
<211>  27
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  330

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Asn Thr Ser 
1               5                   10                  15      


Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25          


<210>  331
<211>  23
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  331

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Ser Gly Thr Thr Glu 
1               5                   10                  15      


Ile Glu Ala Cys Ile Leu Leu 
            20              


<210>  332
<211>  19
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  332

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Thr Glu Ile Glu Ala Cys 
1               5                   10                  15      


Ile Leu Leu 
            


<210>  333
<211>  15
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  333

Pro Ala Ile Cys Gln Arg Ala Glu Ile Glu Ala Cys Ile Leu Leu 
1               5                   10                  15  


<210>  334
<211>  29
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  334

Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn 
1               5                   10                  15      


Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25                  


<210>  335
<211>  28
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  335

Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn Thr 
1               5                   10                  15      


Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25              


<210>  336
<211>  27
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  336

Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser Asn Thr Ser 
1               5                   10                  15      


Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu Leu 
            20                  25          


<210>  337
<211>  29
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  337

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile Leu 
            20                  25                  


<210>  338
<211>  28
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  338

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys Ile 
            20                  25              


<210>  339
<211>  27
<212>  PRT
<213>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  339

Pro Ala Ile Cys Gln Arg Ala Thr Ala Thr Leu Gly Thr Val Gly Ser 
1               5                   10                  15      


Asn Thr Ser Gly Thr Thr Glu Ile Glu Ala Cys 
            20                  25          


<210>  340
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  340

Ile Val Val Thr Ala Pro Ala Asp Leu Trp Asp Trp Ile Arg Ala 
1               5                   10                  15  


<210>  341
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  341

Ile Thr Val Thr Met Pro Ala Asp Leu Trp Asp Trp Ile Arg Ala 
1               5                   10                  15  


<210>  342
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  342

Ile Val Val Thr Ile Pro Ala Asp Leu Trp Asp Trp Ile Arg Ala 
1               5                   10                  15  


<210>  343
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  343

Ile Val Val Thr Leu Pro Ala Asp Leu Trp Asp Trp Ile Arg Ala 
1               5                   10                  15  


<210>  344
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  344

Ile Val Val Thr Val Pro Ala Asp Leu Trp Asp Trp Ile Arg Ala 
1               5                   10                  15  


<210>  345
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  345

Ile Val Val Thr Met Pro Ala Asp Leu Trp Asp Trp Ile Met Ala 
1               5                   10                  15  


<210>  346
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  346

Ile Val Val Thr Met Pro Ala Asp Leu Trp Asp Trp Ile Asn Ala 
1               5                   10                  15  


<210>  347
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  347

Ile Val Val Thr Met Pro Ala Asp Leu Trp Asp Trp Ile Gln Ala 
1               5                   10                  15  


<210>  348
<211>  15
<212>  PRT
<213>  synthetic construct

<400>  348

Ile His Val Thr Ile Pro Ala Asp Leu Trp Asp Trp Ile Asn Lys 
1               5                   10                  15  


<210>  349
<211>  14
<212>  PRT
<213>  synthetic construct

<400>  349

Ile His Val Thr Ile Pro Ala Asp Leu Trp Asp Trp Ile Asn 
1               5                   10                  


<210>  350
<211>  36
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (4)..(4)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  4-fluoro-L-phenylalanine

<220>
<221>  SITE
<222>  (29)..(29)
<223>  gamma-carboxyglutamic acid

<400>  350

Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Xaa Leu Asp 
1               5                   10                  15      


Pro Asn Leu Thr Glu Glu Gln Arg Trp Glu Lys Ile Xaa Lys Ile Asn 
            20                  25                  30          


Asp Glu Cys Glu 
        35      


<210>  351
<211>  37
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (4)..(4)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  4-fluoro-L-phenylalanine

<220>
<221>  SITE
<222>  (29)..(29)
<223>  gamma-carboxyglutamic acid

<220>
<221>  SITE
<222>  (31)..(31)
<223>  PEG30L

<400>  351

Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Xaa Leu Asp 
1               5                   10                  15      


Pro Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Xaa Lys Xaa Ile 
            20                  25                  30          


Asn Asp Glu Cys Glu 
        35          


<210>  352
<211>  37
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (4)..(4)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  4-fluoro-L-phenylalanine

<220>
<221>  SITE
<222>  (29)..(29)
<223>  gamma-carboxyglutamic acid

<220>
<221>  SITE
<222>  (31)..(31)
<223>  PEG20Br

<400>  352

Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Xaa Leu Asp 
1               5                   10                  15      


Pro Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Xaa Lys Xaa Ile 
            20                  25                  30          


Asn Asp Glu Cys Glu 
        35          


<210>  353
<211>  37
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (4)..(4)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  4-fluoro-L-phenylalanine

<220>
<221>  SITE
<222>  (29)..(29)
<223>  gamma-carboxyglutamic acid

<220>
<221>  SITE
<222>  (31)..(31)
<223>  PEG40Br

<400>  353

Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Xaa Leu Asp 
1               5                   10                  15      


Pro Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Xaa Lys Xaa Ile 
            20                  25                  30          


Asn Asp Glu Cys Glu 
        35          


<210>  354
<211>  35
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (3)..(3)
<223>  Homoleucine

<400>  354

Phe Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Phe Leu Asp Pro 
1               5                   10                  15      


Asn Leu Thr Glu Gln Gln Arg Trp Glu Lys Ile Asp Lys Ile Asn Asp 
            20                  25                  30          


Glu Cys Glu 
        35  


<210>  355
<211>  36
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (4)..(4)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (14)..(14)
<223>  4-fluoro-L-phenylalanine

<220>
<221>  SITE
<222>  (29)..(29)
<223>  gamma-carboxyglutamic acid

<400>  355

Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Xaa Leu Asp 
1               5                   10                  15      


Pro Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Xaa Lys Ile Asn 
            20                  25                  30          


Asp Glu Cys Glu 
        35      


<210>  356
<211>  38
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (6)..(6)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (19)..(19)
<223>  N-epsilon-acetyl-L-Lys

<400>  356

Ser Trp Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Phe 
1               5                   10                  15      


Leu Asp Xaa Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Asp Lys 
            20                  25                  30          


Ile Asn Asp Glu Cys Glu 
        35              


<210>  357
<211>  38
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (6)..(6)
<223>  cyclohexyl-L-alanine

<220>
<221>  SITE
<222>  (19)..(19)
<223>  40 kDa branched PEG-Lys

<400>  357

Ser Trp Gln Ser Asp Xaa Asp Cys Ile His Arg Leu Leu Glu Ala Phe 
1               5                   10                  15      


Leu Asp Lys Asn Leu Thr Glu Glu Gln Arg Trp Glu Arg Ile Asp Lys 
            20                  25                  30          


Ile Asn Asp Glu Cys Glu 
        35              


<210>  358
<211>  29
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (3)..(3)
<223>  selected from A, F, H, K, Q, R, S, W and Y

<220>
<221>  SITE
<222>  (4)..(4)
<223>  selected from A, D, E, F, H, I, K, L, M, N, Q, R, S, T, V and Y

<220>
<221>  SITE
<222>  (7)..(7)
<223>  selected from F, H, I, K, L, M, N, R, S, T, V, W and Y

<220>
<221>  SITE
<222>  (11)..(11)
<223>  selected from A, I, K, L, M, N, R, S, T and V

<220>
<221>  SITE
<222>  (16)..(16)
<223>  selected from N and T

<220>
<221>  SITE
<222>  (17)..(17)
<223>  selected from A, I, T and V

<220>
<221>  SITE
<222>  (18)..(18)
<223>  selected from D, E, G, H, K, N, Q, R, S and T

<220>
<221>  SITE
<222>  (20)..(20)
<223>  selected from I, L, M, R, T and V

<220>
<221>  SITE
<222>  (21)..(21)
<223>  selected from A, S, T and V

<220>
<221>  SITE
<222>  (25)..(25)
<223>  selected from I, M, Q, S, T, V and W

<220>
<221>  SITE
<222>  (26)..(26)
<223>  selected from K and S

<220>
<221>  SITE
<222>  (28)..(28)
<223>  selected from F, L, M and Y

<220>
<221>  SITE
<222>  (29)..(29)
<223>  selected from D and R

<400>  358

Glu Glu Xaa Xaa Ala Trp Xaa Glu Ile His Xaa Leu Pro Asn Leu Xaa 
1               5                   10                  15      


Xaa Xaa Gln Xaa Xaa Ala Phe Ile Xaa Xaa Leu Xaa Xaa 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  synthetic construct


<220>
<221>  SITE
<222>  (3)..(3)
<223>  selected from A, F, H, K, Q, R, S, W and Y

<220>
<221>  SITE
<222>  (4)..(4)
<223>  selected from A, D, E, F, H, I, K, L, M, N, Q, R, S, T, V and Y

<220>
<221>  SITE
<222>  (7)..(7)
<223>  selected from F, H, I, K, L, M, N, R, S, T, V, W and Y

<220>
<221>  SITE
<222>  (11)..(11)
<223>  selected from A, I, K, L, M, N, R, S, T and V

<220>
<221>  SITE
<222>  (16)..(16)
<223>  selected from N and T

<220>
<221>  SITE
<222>  (17)..(17)
<223>  selected from A, I, T and V

<220>
<221>  SITE
<222>  (18)..(18)
<223>  selected from D, E, G, H, K, N, Q, R, S and T

<220>
<221>  SITE
<222>  (20)..(20)
<223>  selected from I, L, M, R, T and V

<220>
<221>  SITE
<222>  (21)..(21)
<223>  selected from A, S, T and V

<220>
<221>  SITE
<222>  (25)..(25)
<223>  selected from I, M, Q, S, T, V and W

<220>
<221>  SITE
<222>  (26)..(26)
<223>  selected from K and S

<220>
<221>  SITE
<222>  (28)..(28)
<223>  selected from F, L, M and Y

<220>
<221>  SITE
<222>  (29)..(29)
<223>  selected from D and R

<400>  359

Glu Glu Xaa Xaa Ala Trp Xaa Glu Ile His Xaa Leu Pro Asn Leu Xaa 
1               5                   10                  15      


Xaa Xaa Gln Xaa Xaa Ala Phe Ile Xaa Xaa Leu Xaa Xaa 
            20                  25                  


<210>  360
<211>  49
<212>  PRT
<213>  synthetic construct

<400>  360

Tyr Tyr Ala Leu Ser Asp Ala Lys Glu Glu Glu Pro Arg Tyr Lys Ala 
1               5                   10                  15      


Leu Arg Gly Glu Asn Gln Asp Leu Arg Glu Lys Glu Arg Lys Tyr Gln 
            20                  25                  30          


Asp Lys Ile Lys Lys Leu Glu Glu Lys Glu Lys Asn Leu Glu Lys Lys 
        35                  40                  45              


Ser 
    


