                         SEQUENCE LISTING

<110>  Radius Health
 
<120>  Animal Model Having Homologous Recombination of Mouse PTH1 
       Receptor

<130>  265853-507889

<150>  63/184,688
<151>  2021-05-05

<150>  63/250,647
<151>  2021-09-30

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  568
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human PTH1R protein (exons 4-16)

<400>  1

Val Asp Ala Asp Asp Val Met Thr Lys Glu Glu Gln Ile Phe Leu Leu 
1               5                   10                  15      


His Arg Ala Gln Ala Gln Cys Glu Lys Arg Leu Lys Glu Val Leu Gln 
            20                  25                  30          


Arg Pro Ala Ser Ile Met Glu Ser Asp Lys Gly Trp Thr Ser Ala Ser 
        35                  40                  45              


Thr Ser Gly Lys Pro Arg Lys Asp Lys Ala Ser Gly Lys Leu Tyr Pro 
    50                  55                  60                  


Glu Ser Glu Glu Asp Lys Glu Ala Pro Thr Gly Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Arg Pro Cys Leu Pro Glu Trp Asp His Ile Leu Cys Trp Pro Leu Gly 
                85                  90                  95      


Ala Pro Gly Glu Val Val Ala Val Pro Cys Pro Asp Tyr Ile Tyr Asp 
            100                 105                 110         


Phe Asn His Lys Gly His Ala Tyr Arg Arg Cys Asp Arg Asn Gly Ser 
        115                 120                 125             


Trp Glu Leu Val Pro Gly His Asn Arg Thr Trp Ala Asn Tyr Ser Glu 
    130                 135                 140                 


Cys Val Lys Phe Leu Thr Asn Glu Thr Arg Glu Arg Glu Val Phe Asp 
145                 150                 155                 160 


Arg Leu Gly Met Ile Tyr Thr Val Gly Tyr Ser Val Ser Leu Ala Ser 
                165                 170                 175     


Leu Thr Val Ala Val Leu Ile Leu Ala Tyr Phe Arg Arg Leu His Cys 
            180                 185                 190         


Thr Arg Asn Tyr Ile His Met His Leu Phe Leu Ser Phe Met Leu Arg 
        195                 200                 205             


Ala Val Ser Ile Phe Val Lys Asp Ala Val Leu Tyr Ser Gly Ala Thr 
    210                 215                 220                 


Leu Asp Glu Ala Glu Arg Leu Thr Glu Glu Glu Leu Arg Ala Ile Ala 
225                 230                 235                 240 


Gln Ala Pro Pro Pro Pro Ala Thr Ala Ala Ala Gly Tyr Ala Gly Cys 
                245                 250                 255     


Arg Val Ala Val Thr Phe Phe Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr 
            260                 265                 270         


Trp Ile Leu Val Glu Gly Leu Tyr Leu His Ser Leu Ile Phe Met Ala 
        275                 280                 285             


Phe Phe Ser Glu Lys Lys Tyr Leu Trp Gly Phe Thr Val Phe Gly Trp 
    290                 295                 300                 


Gly Leu Pro Ala Val Phe Val Ala Val Trp Val Ser Val Arg Ala Thr 
305                 310                 315                 320 


Leu Ala Asn Thr Gly Cys Trp Asp Leu Ser Ser Gly Asn Lys Lys Trp 
                325                 330                 335     


Ile Ile Gln Val Pro Ile Leu Ala Ser Ile Val Leu Asn Phe Ile Leu 
            340                 345                 350         


Phe Ile Asn Ile Val Arg Val Leu Ala Thr Lys Leu Arg Glu Thr Asn 
        355                 360                 365             


Ala Gly Arg Cys Asp Thr Arg Gln Gln Tyr Arg Lys Leu Leu Lys Ser 
    370                 375                 380                 


Thr Leu Val Leu Met Pro Leu Phe Gly Val His Tyr Ile Val Phe Met 
385                 390                 395                 400 


Ala Thr Pro Tyr Thr Glu Val Ser Gly Thr Leu Trp Gln Val Gln Met 
                405                 410                 415     


His Tyr Glu Met Leu Phe Asn Ser Phe Gln Gly Phe Phe Val Ala Ile 
            420                 425                 430         


Ile Tyr Cys Phe Cys Asn Gly Glu Val Gln Ala Glu Ile Lys Lys Ser 
        435                 440                 445             


Trp Ser Arg Trp Thr Leu Ala Leu Asp Phe Lys Arg Lys Ala Arg Ser 
    450                 455                 460                 


Gly Ser Ser Ser Tyr Ser Tyr Gly Pro Met Val Ser His Thr Ser Val 
465                 470                 475                 480 


Thr Asn Val Gly Pro Arg Val Gly Leu Gly Leu Pro Leu Ser Pro Arg 
                485                 490                 495     


Leu Leu Pro Thr Ala Thr Thr Asn Gly His Pro Gln Leu Pro Gly His 
            500                 505                 510         


Ala Lys Pro Gly Thr Pro Ala Leu Glu Thr Leu Glu Thr Thr Pro Pro 
        515                 520                 525             


Ala Met Ala Ala Pro Lys Asp Asp Gly Phe Leu Asn Gly Ser Cys Ser 
    530                 535                 540                 


Gly Leu Asp Glu Glu Ala Ser Gly Pro Glu Arg Pro Pro Ala Leu Leu 
545                 550                 555                 560 


Gln Glu Glu Trp Glu Thr Val Met 
                565             


<210>  2
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human influenza hemagglutinin(HA)epitope tag

<400>  2

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human residues 88-96

<400>  3

Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
1               5                   


<210>  4
<211>  1707
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human PTH1R exons 4~16 coding sequence-HA

<400>  4
gtggatgcag atgacgtcat gactaaagag gaacagatct tcctgctgca ccgtgctcag       60

gcccagtgcg aaaaacggct caaggaggtc ctgcagaggc cagccagcat aatggaatca      120

gacaagggat ggacatctgc gtccacatca gggaagccca ggaaagataa ggcatctggg      180

aagctctacc cttacgatgt tccggactac gcggcaccca ctggcagcag gtaccgaggg      240

cgcccctgtc tgccggaatg ggaccacatc ctgtgctggc cgctgggggc accaggtgag      300

gtggtggctg tgccctgtcc ggactacatt tatgacttca atcacaaagg ccatgcctac      360

cgacgctgtg accgcaatgg cagctgggag ctggtgcctg ggcacaacag gacgtgggcc      420

aactacagcg agtgtgtcaa atttctcacc aatgagactc gtgaacggga ggtgtttgac      480

cgcctgggca tgatttacac cgtgggctac tccgtgtccc tggcgtccct caccgtagct      540

gtgctcatcc tggcctactt taggcggctg cactgcacgc gcaactacat ccacatgcac      600

ctgttcctgt ccttcatgct gcgcgccgtg agcatcttcg tcaaggacgc tgtgctctac      660

tctggcgcca cgcttgatga ggctgagcgc ctcaccgagg aggagctgcg cgccatcgcc      720

caggcgcccc cgccgcctgc caccgccgct gccggctacg cgggctgcag ggtggctgtg      780

accttcttcc tttacttcct ggccaccaac tactactgga ttctggtgga ggggctgtac      840

ctgcacagcc tcatcttcat ggccttcttc tcagagaaga agtacctgtg gggcttcaca      900

gtcttcggct ggggtctgcc cgctgtcttc gtggctgtgt gggtcagtgt cagagctacc      960

ctggccaaca ccgggtgctg ggacttgagc tccgggaaca aaaagtggat catccaggtg     1020

cccatcctgg cctccattgt gctcaacttc atcctcttca tcaatatcgt ccgggtgctc     1080

gccaccaagc tgcgggagac caacgccggc cggtgtgaca cacggcagca gtaccggaag     1140

ctgctcaaat ccacgctggt gctcatgccc ctctttggcg tccactacat tgtcttcatg     1200

gccacaccat acaccgaggt ctcagggacg ctctggcaag tccagatgca ctatgagatg     1260

ctcttcaact ccttccaggg attttttgtc gcaatcatat actgtttctg caatggcgag     1320

gtacaagctg agatcaagaa atcttggagc cgctggacac tggcactgga cttcaagcga     1380

aaggcacgca gcgggagcag cagctatagc tacggcccca tggtgtccca cacaagtgtg     1440

accaatgtcg gcccccgtgt gggactcggc ctgcccctca gcccccgcct actgcccact     1500

gccaccacca acggccaccc tcagctgcct ggccatgcca agccagggac cccagccctg     1560

gagaccctcg agaccacacc acctgccatg gctgctccca aggacgatgg gttcctcaac     1620

ggctcctgct caggcctgga cgaggaggcc tctgggcctg agcggccacc tgccctgcta     1680

caggaagagt gggagacagt catgtga                                         1707


<210>  5
<211>  2238
<212>  DNA
<213>  Mus musculus

<400>  5
attaattttt cttttcaagc ccgagctggg acttaggccg tttcctgtcc cccaccagct       60

gtgtccttgc tcaggcctga attggagaca cctctctgaa gttccatggc ctccccatgg      120

ccaacctgag tcagctcctc aacccgaggc cccgtttgaa aggcctgtgg attccagatg      180

agaagactga gaccaggata ccgggagagt cctagtgggc aggacacaca attgggccgg      240

cggcggctgc cccgagggac gcggccctag gcggtggcga tggggaccgc ccggatcgca      300

cccagcctgg cgctccttct ctgctgccca gtgctcagct ccgcatatgc gctggtggac      360

gcagacgatg tctttaccaa agaggaacag attttcctgc tgcaccgtgc ccaggcgcaa      420

tgtgacaagc tgctcaagga agttctgcac acagcagcca acataatgga gtcagacaaa      480

gggtggacgc cagcatctac gtcagggaag cccaggaaag agaaggcacc gggaaagttc      540

taccccgagt ctaaagagaa caaggatgtg cccaccggca gcaggcgccg agggcgtccc      600

tgtctgccag agtgggacaa catcgtttgc tggccattgg gggcaccagg tgaagtggtg      660

gcagtacctt gtcccgatta catttatgac ttcaaccaca aaggccatgc ctacagacgc      720

tgcgaccgca atggcagctg ggaggtggtt ccagggcaca accggacgtg ggccaactac      780

agcgagtgcc tcaagttcat gaccaatgag actcgggaac gggaggtatt tgaccgcctg      840

ggcatgatct acaccgtggg atattccatg tctcttgcct ccctcaccgt ggctgtgctc      900

atcctagcct attttaggcg gctgcactgc acgcgcaact acatccacat gcacatgttc      960

ctgtcgttta tgctgcgcgc cgcgagcatc ttcgtgaagg acgctgtgct ctactctggc     1020

ttcacgctgg atgaggccga gcgcctcacg gaggaagagt tgcatatcat cgcgcaggtg     1080

ccgcctccgc ccgccgctgc cgccgttggc tacgctggct gccgtgtggc cgtgaccttc     1140

ttcctctact tcctggctac caactactac tggattctgg tggagggact gtacttacac     1200

agcctcatct tcatggcctt tttctcagag aagaagtatc tgtggggctt caccatcttt     1260

ggctggggtc tgccggctgt cttcgtggct gtgtgggtcg gtgtcagagc aaccttggcc     1320

aacactgggt gctgggacct gagctctggg cacaagaagt ggatcatcca ggtgcccatc     1380

ctggcatctg ttgtgctcaa cttcatcctc tttatcaaca tcatccgggt gcttgccact     1440

aagcttcggg agaccaatgc gggccggtgt gacaccaggc agcagtaccg gaagctgctc     1500

aggtccacgt tggtgcttgt gccactcttc ggtgtccact acaccgtctt catggccttg     1560

ccgtacaccg aggtctcagg gacactgtgg cagatccaga tgcactatga gatgctcttc     1620

aactccttcc agggattttt tgttgccatc atatactgtt tctgcaatgg tgaggtgcag     1680

gcagagatta ggaagtcttg gagccgctgg acactggcat tggacttcaa gcgtaaagca     1740

cgaagtggga gtagcagcta cagctatggc ccaatggtgt cacacacgag tgtgaccaat     1800

gtgggccccc gtgcaggact cagccttccc cttagccccc gcctgcttcc tgccaccacc     1860

aatggccact cccagctgcc tggccacgcc aagccgggcg ctccagccat tgagaacgaa     1920

accataccag ttactatgac agttcccaag gacgacggct tccttaatgg ctcctgctcg     1980

ggtctggatg aggaggcctc tgggtctgcg cggccacctc cattgttgca ggaagaatgg     2040

gaaacagtca tgtgactggg catcaagggg ctggactgct ggcatgggca gatggacaga     2100

tggaccaaga agccagagtt tggctggctg tctattcagg actggaccag gaagacaaaa     2160

ggaaaagaga aaaaaaaaaa aaaaaagaag ggagctgtgt gtggcttcct gtgttgtgct     2220

caagaaaaaa aaaaaaaa                                                   2238


<210>  6
<211>  2153
<212>  DNA
<213>  Homo sapien

<400>  6
agcactatcc ttgcttaggc ctgagccaca gaagctgctc agggactatc catggcctcc       60

ccgtggccaa cttgagtctg ctctgcagct ttaggcccga cttggaaggc ccatgggctg      120

cagatgagga aactgaggtc cagacagccg aagagtggta gtgtccagga cacacaactg      180

ggccggcggc ggcggctgcc ccgagggacg cggccctagg cggtggcgat ggggaccgcc      240

cggatcgcac ccggcctggc gctcctgctc tgctgccccg tgctcagctc cgcgtacgcg      300

ctggtggatg cagatgacgt catgactaaa gaggaacaga tcttcctgct gcaccgtgct      360

caggcccagt gcgaaaaacg gctcaaggag gtcctgcaga ggccagccag cataatggaa      420

tcagacaagg gatggacatc tgcgtccaca tcagggaagc ccaggaaaga taaggcatct      480

gggaagctct accctgagtc tgaggaggac aaggaggcac ccactggcag caggtaccga      540

gggcgcccct gtctgccgga atgggaccac atcctgtgct ggccgctggg ggcaccaggt      600

gaggtggtgg ctgtgccctg tccggactac atttatgact tcaatcacaa aggccatgcc      660

taccgacgct gtgaccgcaa tggcagctgg gagctggtgc ctgggcacaa caggacgtgg      720

gccaactaca gcgagtgtgt caaatttctc accaatgaga ctcgtgaacg ggaggtgttt      780

gaccgcctgg gcatgattta caccgtgggc tactccgtgt ccctggcgtc cctcaccgta      840

gctgtgctca tcctggccta ctttaggcgg ctgcactgca cgcgcaacta catccacatg      900

cacctgttcc tgtccttcat gctgcgcgcc gtgagcatct tcgtcaagga cgctgtgctc      960

tactctggcg ccacgcttga tgaggctgag cgcctcaccg aggaggagct gcgcgccatc     1020

gcccaggcgc ccccgccgcc tgccaccgcc gctgccggct acgcgggctg cagggtggct     1080

gtgaccttct tcctttactt cctggccacc aactactact ggattctggt ggaggggctg     1140

tacctgcaca gcctcatctt catggccttc ttctcagaga agaagtacct gtggggcttc     1200

acagtcttcg gctggggtct gcccgctgtc ttcgtggctg tgtgggtcag tgtcagagct     1260

accctggcca acaccgggtg ctgggacttg agctccggga acaaaaagtg gatcatccag     1320

gtgcccatcc tggcctccat tgtgctcaac ttcatcctct tcatcaatat cgtccgggtg     1380

ctcgccacca agctgcggga gaccaacgcc ggccggtgtg acacacggca gcagtaccgg     1440

aagctgctca aatccacgct ggtgctcatg cccctctttg gcgtccacta cattgtcttc     1500

atggccacac catacaccga ggtctcaggg acgctctggc aagtccagat gcactatgag     1560

atgctcttca actccttcca gggatttttt gtcgcaatca tatactgttt ctgcaatggc     1620

gaggtacaag ctgagatcaa gaaatcttgg agccgctgga cactggcact ggacttcaag     1680

cgaaaggcac gcagcgggag cagcagctat agctacggcc ccatggtgtc ccacacaagt     1740

gtgaccaatg tcggcccccg tgtgggactc ggcctgcccc tcagcccccg cctactgccc     1800

actgccacca ccaacggcca ccctcagctg cctggccatg ccaagccagg gaccccagcc     1860

ctggagaccc tcgagaccac accacctgcc atggctgctc ccaaggacga tgggttcctc     1920

aacggctcct gctcaggcct ggacgaggag gcctctgggc ctgagcggcc acctgccctg     1980

ctacaggaag agtgggagac agtcatgtga ccaggcgctg ggggctggac ctgctgacat     2040

agtggatgga cagatggacc aaaagatggg tggttgaatg atttcccact cagggctggg     2100

gccaagagga aaaacaggga aaaaaagaaa aaaaaaagaa aaaggaaaag gaa            2153


<210>  7
<211>  27
<212>  DNA
<213>  Homo sapien

<400>  7
tacccttacg atgttccgga ctacgcg                                           27


<210>  8
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F4

<400>  8
gactccccac attctctctg aag                                               23


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R2

<400>  9
gcgtagtccg gaacatcgta a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F2

<400>  10
gatccttacc ttccgggact c                                                 21


<210>  11
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R3

<400>  11
agttctaggg atgctggttc tatg                                              24


<210>  12
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F3

<400>  12
catagaaaag ccttgacttg aggtt                                             25


<210>  13
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R1

<400>  13
tctctttaag gaagttggcc cag                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F4

<400>  14
gactccccac attctctctg aag                                               23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R2

<400>  15
gcgtagtccg gaacatcgta a                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F1

<400>  16
caggcgatcc ttaccttccg                                                   20


<210>  17
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R1

<400>  17
tctctttaag gaagttggcc cag                                               23


<210>  18
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F3

<400>  18
catagaaaag ccttgacttg aggtt                                             25


<210>  19
<211>  115
<212>  PRT
<213>  Homo sapien

<400>  19

Met Ile Pro Ala Lys Asp Met Ala Lys Val Met Ile Val Met Leu Ala 
1               5                   10                  15      


Ile Cys Phe Leu Thr Lys Ser Asp Gly Lys Ser Val Lys Lys Arg Ser 
            20                  25                  30          


Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
        35                  40                  45              


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
    50                  55                  60                  


Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser Gln 
65                  70                  75                  80  


Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu Lys 
                85                  90                  95      


Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys Ala 
            100                 105                 110         


Lys Ser Gln 
        115 


<210>  20
<211>  34
<212>  PRT
<213>  Homo sapien

<400>  20

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  21
<211>  36
<212>  PRT
<213>  Homo sapien

<400>  21

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His 
            20                  25                  30          


Thr Ala Glu Ile 
        35      


<210>  22
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Abaloparatide


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln 
1               5                   10                  15      


Asp Leu Arg Arg Arg Glu Leu Leu Glu Lys Leu Leu Xaa Lys Leu His 
            20                  25                  30          


Thr Ala 
        


<210>  23
<211>  346
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3 Junction consensus sequence

<400>  23
tgaggttaga ttttttttat attttgtttt gtgttatttt tttctttaac atccctaaaa       60

ttttccttac atgttttact agccagattt ttcctcctct cctgactact cccagtcata      120

gctgtccctc ttctcttatg gagatcctgg agggacctaa taacttcgta tagcatacat      180

tatacgaagt tatattaagg gttattgaat atgatcggaa ttgggctgca ggaattcgat      240

agcttggctg caggtcgacg tacgtagcaa gcttgatggg ccctggtacc ccggggtccc      300

agtggattta gatggggttg ggcaagccag ggactttgct gagggc                     346


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R-291 reverse primer

<400>  24
aggaagtaaa ggaagaaggt cacag                                             25


<210>  25
<211>  344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Consensus.F3_R-291 Sequence.vers 3

<400>  25
gccgctgggg gcaccaggtg aggtggtggc tgtgccctgt ccggactaca tttatgactt       60

caatcacaaa ggccatgcct accgacgctg tgaccgcaat ggcagctggg agctggtgcc      120

tgggcacaac aggacgtggg ccaactacag cgagtgtgtc aaatttctca ccaatgagac      180

tcgtgaacgg gaggtgtttg accgcctggg catgatttac accgtgggct actccgtgtc      240

cctggcgtcc ctcaccgtag ctgtgctcat cctggcctac tttagcggct gcactgcacg      300

cgcaactaca tccacatgca cctgttcctg tccttcatgc tgcg                       344


<210>  26
<211>  22
<212>  PRT
<213>  Homo sapien

<400>  26

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala 
            20          


<210>  27
<211>  2153
<212>  DNA
<213>  Homo sapien

<400>  27
agcactatcc ttgcttaggc ctgagccaca gaagctgctc agggactatc catggcctcc       60

ccgtggccaa cttgagtctg ctctgcagct ttaggcccga cttggaaggc ccatgggctg      120

cagatgagga aactgaggtc cagacagccg aagagtggta gtgtccagga cacacaactg      180

ggccggcggc ggcggctgcc ccgagggacg cggccctagg cggtggcgat ggggaccgcc      240

cggatcgcac ccggcctggc gctcctgctc tgctgccccg tgctcagctc cgcgtacgcg      300

ctggtggatg cagatgacgt catgactaaa gaggaacaga tcttcctgct gcaccgtgct      360

caggcccagt gcgaaaaacg gctcaaggag gtcctgcaga ggccagccag cataatggaa      420

tcagacaagg gatggacatc tgcgtccaca tcagggaagc ccaggaaaga taaggcatct      480

gggaagctct accctgagtc tgaggaggac aaggaggcac ccactggcag caggtaccga      540

gggcgcccct gtctgccgga atgggaccac atcctgtgct ggccgctggg ggcaccaggt      600

gaggtggtgg ctgtgccctg tccggactac atttatgact tcaatcacaa aggccatgcc      660

taccgacgct gtgaccgcaa tggcagctgg gagctggtgc ctgggcacaa caggacgtgg      720

gccaactaca gcgagtgtgt caaatttctc accaatgaga ctcgtgaacg ggaggtgttt      780

gaccgcctgg gcatgattta caccgtgggc tactccgtgt ccctggcgtc cctcaccgta      840

gctgtgctca tcctggccta ctttaggcgg ctgcactgca cgcgcaacta catccacatg      900

cacctgttcc tgtccttcat gctgcgcgcc gtgagcatct tcgtcaagga cgctgtgctc      960

tactctggcg ccacgcttga tgaggctgag cgcctcaccg aggaggagct gcgcgccatc     1020

gcccaggcgc ccccgccgcc tgccaccgcc gctgccggct acgcgggctg cagggtggct     1080

gtgaccttct tcctttactt cctggccacc aactactact ggattctggt ggaggggctg     1140

tacctgcaca gcctcatctt catggccttc ttctcagaga agaagtacct gtggggcttc     1200

acagtcttcg gctggggtct gcccgctgtc ttcgtggctg tgtgggtcag tgtcagagct     1260

accctggcca acaccgggtg ctgggacttg agctccggga acaaaaagtg gatcatccag     1320

gtgcccatcc tggcctccat tgtgctcaac ttcatcctct tcatcaatat cgtccgggtg     1380

ctcgccacca agctgcggga gaccaacgcc ggccggtgtg acacacggca gcagtaccgg     1440

aagctgctca aatccacgct ggtgctcatg cccctctttg gcgtccacta cattgtcttc     1500

atggccacac catacaccga ggtctcaggg acgctctggc aagtccagat gcactatgag     1560

atgctcttca actccttcca gggatttttt gtcgcaatca tatactgttt ctgcaatggc     1620

gaggtacaag ctgagatcaa gaaatcttgg agccgctgga cactggcact ggacttcaag     1680

cgaaaggcac gcagcgggag cagcagctat agctacggcc ccatggtgtc ccacacaagt     1740

gtgaccaatg tcggcccccg tgtgggactc ggcctgcccc tcagcccccg cctactgccc     1800

actgccacca ccaacggcca ccctcagctg cctggccatg ccaagccagg gaccccagcc     1860

ctggagaccc tcgagaccac accacctgcc atggctgctc ccaaggacga tgggttcctc     1920

aacggctcct gctcaggcct ggacgaggag gcctctgggc ctgagcggcc acctgccctg     1980

ctacaggaag agtgggagac agtcatgtga ccaggcgctg ggggctggac ctgctgacat     2040

agtggatgga cagatggacc aaaagatggg tggttgaatg atttcccact cagggctggg     2100

gccaagagga aaaacaggga aaaaaagaaa aaaaaaagaa aaaggaaaag gaa            2153


<210>  28
<211>  593
<212>  PRT
<213>  Homo sapien

<400>  28

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  29
<211>  568
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human PTH1R protein (exons 4-16)-HA

<400>  29

Val Asp Ala Asp Asp Val Met Thr Lys Glu Glu Gln Ile Phe Leu Leu 
1               5                   10                  15      


His Arg Ala Gln Ala Gln Cys Glu Lys Arg Leu Lys Glu Val Leu Gln 
            20                  25                  30          


Arg Pro Ala Ser Ile Met Glu Ser Asp Lys Gly Trp Thr Ser Ala Ser 
        35                  40                  45              


Thr Ser Gly Lys Pro Arg Lys Asp Lys Ala Ser Gly Lys Leu Tyr Pro 
    50                  55                  60                  


Tyr Asp Val Pro Asp Tyr Ala Ala Pro Thr Gly Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Arg Pro Cys Leu Pro Glu Trp Asp His Ile Leu Cys Trp Pro Leu Gly 
                85                  90                  95      


Ala Pro Gly Glu Val Val Ala Val Pro Cys Pro Asp Tyr Ile Tyr Asp 
            100                 105                 110         


Phe Asn His Lys Gly His Ala Tyr Arg Arg Cys Asp Arg Asn Gly Ser 
        115                 120                 125             


Trp Glu Leu Val Pro Gly His Asn Arg Thr Trp Ala Asn Tyr Ser Glu 
    130                 135                 140                 


Cys Val Lys Phe Leu Thr Asn Glu Thr Arg Glu Arg Glu Val Phe Asp 
145                 150                 155                 160 


Arg Leu Gly Met Ile Tyr Thr Val Gly Tyr Ser Val Ser Leu Ala Ser 
                165                 170                 175     


Leu Thr Val Ala Val Leu Ile Leu Ala Tyr Phe Arg Arg Leu His Cys 
            180                 185                 190         


Thr Arg Asn Tyr Ile His Met His Leu Phe Leu Ser Phe Met Leu Arg 
        195                 200                 205             


Ala Val Ser Ile Phe Val Lys Asp Ala Val Leu Tyr Ser Gly Ala Thr 
    210                 215                 220                 


Leu Asp Glu Ala Glu Arg Leu Thr Glu Glu Glu Leu Arg Ala Ile Ala 
225                 230                 235                 240 


Gln Ala Pro Pro Pro Pro Ala Thr Ala Ala Ala Gly Tyr Ala Gly Cys 
                245                 250                 255     


Arg Val Ala Val Thr Phe Phe Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr 
            260                 265                 270         


Trp Ile Leu Val Glu Gly Leu Tyr Leu His Ser Leu Ile Phe Met Ala 
        275                 280                 285             


Phe Phe Ser Glu Lys Lys Tyr Leu Trp Gly Phe Thr Val Phe Gly Trp 
    290                 295                 300                 


Gly Leu Pro Ala Val Phe Val Ala Val Trp Val Ser Val Arg Ala Thr 
305                 310                 315                 320 


Leu Ala Asn Thr Gly Cys Trp Asp Leu Ser Ser Gly Asn Lys Lys Trp 
                325                 330                 335     


Ile Ile Gln Val Pro Ile Leu Ala Ser Ile Val Leu Asn Phe Ile Leu 
            340                 345                 350         


Phe Ile Asn Ile Val Arg Val Leu Ala Thr Lys Leu Arg Glu Thr Asn 
        355                 360                 365             


Ala Gly Arg Cys Asp Thr Arg Gln Gln Tyr Arg Lys Leu Leu Lys Ser 
    370                 375                 380                 


Thr Leu Val Leu Met Pro Leu Phe Gly Val His Tyr Ile Val Phe Met 
385                 390                 395                 400 


Ala Thr Pro Tyr Thr Glu Val Ser Gly Thr Leu Trp Gln Val Gln Met 
                405                 410                 415     


His Tyr Glu Met Leu Phe Asn Ser Phe Gln Gly Phe Phe Val Ala Ile 
            420                 425                 430         


Ile Tyr Cys Phe Cys Asn Gly Glu Val Gln Ala Glu Ile Lys Lys Ser 
        435                 440                 445             


Trp Ser Arg Trp Thr Leu Ala Leu Asp Phe Lys Arg Lys Ala Arg Ser 
    450                 455                 460                 


Gly Ser Ser Ser Tyr Ser Tyr Gly Pro Met Val Ser His Thr Ser Val 
465                 470                 475                 480 


Thr Asn Val Gly Pro Arg Val Gly Leu Gly Leu Pro Leu Ser Pro Arg 
                485                 490                 495     


Leu Leu Pro Thr Ala Thr Thr Asn Gly His Pro Gln Leu Pro Gly His 
            500                 505                 510         


Ala Lys Pro Gly Thr Pro Ala Leu Glu Thr Leu Glu Thr Thr Pro Pro 
        515                 520                 525             


Ala Met Ala Ala Pro Lys Asp Asp Gly Phe Leu Asn Gly Ser Cys Ser 
    530                 535                 540                 


Gly Leu Asp Glu Glu Ala Ser Gly Pro Glu Arg Pro Pro Ala Leu Leu 
545                 550                 555                 560 


Gln Glu Glu Trp Glu Thr Val Met 
                565             


<210>  30
<211>  593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HA-Tag hPTH1R

<400>  30

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  31
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mouse PTH1R residues 1-25

<400>  31

Met Gly Thr Ala Arg Ile Ala Pro Ser Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human PTH1R residues 1-25

<400>  32

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu 
            20                  25  


<210>  33
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F3-Int3 (Fwd)

<400>  33
gactccccac attctctctg aag                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F-HA86 (Fwd)

<400>  34
ggaagctcta cccttacgat gtt                                               23


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R2-HA95 (Rev)

<400>  35
gcgtagtccg gaacatcgta a                                                 21


<210>  36
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F-I255 (Fwd)

<400>  36
catcttcgtc aaggacgctg tg                                                22


<210>  37
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R-291 (Rev)

<400>  37
aggaagtaaa ggaagaaggt cacag                                             25


<210>  38
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F-mid.ins (Fwd)

<400>  38
ggcgtccact acattgtctt catg                                              24


<210>  39
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R-mid.ins (Rev)

<400>  39
catgaagaca atgtagtgga cgcc                                              24


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F-M611 (Fwd)

<400>  40
gaagagtggg agacagtcat g                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R-M611 (Rev)

<400>  41
catgactgtc tcccactctt c                                                 21


<210>  42
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F2-rbg (Fwd)

<400>  42
catagaaaag ccttgacttg aggtt                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R-rbg (Rev)

<400>  43
aacctcaagt caaggctttt ctatg                                             25


<210>  44
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  R1.int4 (Rev)

<400>  44
tctctttaag gaagttggcc cag                                               23


<210>  45
<211>  2600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleotide Sequence of hP1R KI region

<400>  45
gactccccac attctctctg aagggatcac ttttcgaaag gggggaaatc cctggggagg       60

ttgcatgagt ttggaaccag ctgcctcacc tggaagtgct gcctacagtc tgacctttgg      120

tttggcaggt ggatgcagat gacgtcatga ctaaagagga acagatcttc ctgctgcacc      180

gtgctcaggc ccagtgcgaa aaacggctca aggaggtcct gcagaggcca gccagcataa      240

tggaatcaga caagggatgg acatctgcgt ccacatcagg gaagcccagg aaagataagg      300

catctgggaa gctctaccct tacgatgttc cggactacgc ggcacccact ggcagcaggt      360

accgagggcg cccctgtctg ccggaatggg accacatcct gtgctggccg ctgggggcac      420

caggtgaggt ggtggctgtg ccctgtccgg actacattta tgacttcaat cacaaaggcc      480

atgcctaccg acgctgtgac cgcaatggca gctgggagct ggtgcctggg cacaacagga      540

cgtgggccaa ctacagcgag tgtgtcaaat ttctcaccaa tgagactcgt gaacgggagg      600

tgtttgaccg cctgggcatg atttacaccg tgggctactc cgtgtccctg gcgtccctca      660

ccgtagctgt gctcatcctg gcctacttta ggcggctgca ctgcacgcgc aactacatcc      720

acatgcacct gttcctgtcc ttcatgctgc gcgccgtgag catcttcgtc aaggacgctg      780

tgctctactc tggcgccacg cttgatgagg ctgagcgcct caccgaggag gagctgcgcg      840

ccatcgccca ggcgcccccg ccgcctgcca ccgccgctgc cggctacgcg ggctgcaggg      900

tggctgtgac cttcttcctt tacttcctgg ccaccaacta ctactggatt ctggtggagg      960

ggctgtacct gcacagcctc atcttcatgg ccttcttctc agagaagaag tacctgtggg     1020

gcttcacagt cttcggctgg ggtctgcccg ctgtcttcgt ggctgtgtgg gtcagtgtca     1080

gagctaccct ggccaacacc gggtgctggg acttgagctc cgggaacaaa aagtggatca     1140

tccaggtgcc catcctggcc tccattgtgc tcaacttcat cctcttcatc aatatcgtcc     1200

gggtgctcgc caccaagctg cgggagacca acgccggccg gtgtgacaca cggcagcagt     1260

accggaagct gctcaaatcc acgctggtgc tcatgcccct ctttggcgtc cactacattg     1320

tcttcatggc cacaccatac accgaggtct cagggacgct ctggcaagtc cagatgcact     1380

atgagatgct cttcaactcc ttccagggat tttttgtcgc aatcatatac tgtttctgca     1440

atggcgaggt acaagctgag atcaagaaat cttggagccg ctggacactg gcactggact     1500

tcaagcgaaa ggcacgcagc gggagcagca gctatagcta cggccccatg gtgtcccaca     1560

caagtgtgac caatgtcggc ccccgtgtgg gactcggcct gcccctcagc ccccgcctac     1620

tgcccactgc caccaccaac ggccaccctc agctgcctgg ccatgccaag ccagggaccc     1680

cagccctgga gaccctcgag accacaccac ctgccatggc tgctcccaag gacgatgggt     1740

tcctcaacgg ctcctgctca ggcctggacg aggaggcctc tgggcctgag cggccacctg     1800

ccctgctaca ggaagagtgg gagacagtca tgtgatcctc aggtgcaggc tgcctatcag     1860

aaggtggtgg ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc     1920

tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa     1980

aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg     2040

acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca     2100

acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat     2160

atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag     2220

atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta     2280

catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct     2340

cttctcttat ggagatcctc gagggaccta ataacttcgt atagcataca ttatacgaag     2400

ttatattaag ggttattgaa tatgatcgga attgggctgc aggaattcga tagcttggct     2460

gcaggtcgac gtacgtagca agcttgatgg gccctggtac cacggggtcc cagtggattt     2520

agatggggtt gggcaagcca gggactttgc tgagggcgct ggtccaaaca gggtgggctg     2580

ggccaacttc cttaaagaga                                                 2600


<210>  46
<211>  1707
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hPTHR1 cDNA encoding hPTH1R V26-M593

<400>  46
gtggatgcag atgacgtcat gactaaagag gaacagatct tcctgctgca ccgtgctcag       60

gcccagtgcg aaaaacggct caaggaggtc ctgcagaggc cagccagcat aatggaatca      120

gacaagggat ggacatctgc gtccacatca gggaagccca ggaaagataa ggcatctggg      180

aagctctacc cttacgatgt tccggactac gcggcaccca ctggcagcag gtaccgaggg      240

cgcccctgtc tgccggaatg ggaccacatc ctgtgctggc cgctgggggc accaggtgag      300

gtggtggctg tgccctgtcc ggactacatt tatgacttca atcacaaagg ccatgcctac      360

cgacgctgtg accgcaatgg cagctgggag ctggtgcctg ggcacaacag gacgtgggcc      420

aactacagcg agtgtgtcaa atttctcacc aatgagactc gtgaacggga ggtgtttgac      480

cgcctgggca tgatttacac cgtgggctac tccgtgtccc tggcgtccct caccgtagct      540

gtgctcatcc tggcctactt taggcggctg cactgcacgc gcaactacat ccacatgcac      600

ctgttcctgt ccttcatgct gcgcgccgtg agcatcttcg tcaaggacgc tgtgctctac      660

tctggcgcca cgcttgatga ggctgagcgc ctcaccgagg aggagctgcg cgccatcgcc      720

caggcgcccc cgccgcctgc caccgccgct gccggctacg cgggctgcag ggtggctgtg      780

accttcttcc tttacttcct ggccaccaac tactactgga ttctggtgga ggggctgtac      840

ctgcacagcc tcatcttcat ggccttcttc tcagagaaga agtacctgtg gggcttcaca      900

gtcttcggct ggggtctgcc cgctgtcttc gtggctgtgt gggtcagtgt cagagctacc      960

ctggccaaca ccgggtgctg ggacttgagc tccgggaaca aaaagtggat catccaggtg     1020

cccatcctgg cctccattgt gctcaacttc atcctcttca tcaatatcgt ccgggtgctc     1080

gccaccaagc tgcgggagac caacgccggc cggtgtgaca cacggcagca gtaccggaag     1140

ctgctcaaat ccacgctggt gctcatgccc ctctttggcg tccactacat tgtcttcatg     1200

gccacaccat acaccgaggt ctcagggacg ctctggcaag tccagatgca ctatgagatg     1260

ctcttcaact ccttccaggg attttttgtc gcaatcatat actgtttctg caatggcgag     1320

gtacaagctg agatcaagaa atcttggagc cgctggacac tggcactgga cttcaagcga     1380

aaggcacgca gcgggagcag cagctatagc tacggcccca tggtgtccca cacaagtgtg     1440

accaatgtcg gcccccgtgt gggactcggc ctgcccctca gcccccgcct actgcccact     1500

gccaccacca acggccaccc tcagctgcct ggccatgcca agccagggac cccagccctg     1560

gagaccctcg agaccacacc acctgccatg gctgctccca aggacgatgg gttcctcaac     1620

ggctcctgct caggcctgga cgaggaggcc tctgggcctg agcggccacc tgccctgcta     1680

caggaagagt gggagacagt catgtga                                         1707


