                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  COMPOSITIONS AND METHODS FOR TREATING ALLERGIES AND INFLAMMATORY 
       CONDITIONS

<130>  10504-081WO1

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  2

His Lys Thr Asp Ser Phe Val Gly Leu Met 
1               5                   10  


<210>  3
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala 
1               5                   10                  15      


Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu 
            20                  25                  30          


Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg 
        35                  40                  45              


Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val 
    50                  55                  60                  


Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr 
65                  70                  75                  80  


Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln 
                85                  90                  95      


Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu 
            100                 105                 110         


Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp 
        115                 120                 125             


Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly 
    130                 135                 140                 


Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val 
145                 150                 155                 160 


Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val 
                165                 170                 175     


Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu 
            180                 185                 190         


Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly 
        195                 200                 205             


Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp 
    210                 215                 220                 


Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys 
225                 230                 235                 240 


Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser 
                245                 250                 255     


Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His 
            260                 265                 270         


Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val 
        275                 280                 285             


Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr 
    290                 295                 300                 


Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr 
305                 310                 315                 320 


Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met 
                325                 330                 335     


Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn 
            340                 345                 350         


Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr 
        355                 360                 365             


Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys 
    370                 375                 380                 


Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly 
                405                 410                 415     


Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg 
            420                 425                 430         


Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val 
        435                 440                 445             


Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe 
    450                 455                 460                 


Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu 
465                 470                 475                 480 


Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val 
                485                 490                 495     


Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg 
            500                 505                 510         


Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile 
        515                 520                 525             


Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp 
    530                 535                 540                 


Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu 
545                 550                 555                 560 


Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys 
                565                 570                 575     


His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser 
            580                 585                 590         


Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val 
        595                 600                 605             


Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe 
    610                 615                 620                 


Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met 
625                 630                 635                 640 


Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr 
                645                 650                 655     


Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe 
            660                 665                 670         


Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe 
        675                 680                 685             


Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu 
    690                 695                 700                 


Phe Lys Trp Leu Gln Leu Thr Met Phe Ala 
705                 710                 


<210>  4
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
ccgatgggtt gtaccttgtc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6
cggactccgc aaagtctaag                                                   20


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
cctggctctt gcttgcctt                                                    19


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8
ggtcttgtgt gatgttgctc a                                                 21


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9
gctggacaac atactgctaa cc                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10
atttccgata agcttggcaa                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11
ggctgtattc ccctccatcg                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12
ccagttggta acaatgccat gt                                                22


