                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF CHICAGO
 
<120>  COMPOSITIONS AND METHODS COMPRISING PROTEASE-ACTIVATED 
       THERAPEUTIC AGENTS

<130>  ARCD.P0731WO

<150>  63/185,941
<151>  2021-05-07

<150>  63/313,087
<151>  2022-02-23

<160>  249   

<170>  PatentIn version 3.5

<210>  1
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Cys Thr Gly His His His His His His 
        195                 200         


<210>  2
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Leu Val Pro Arg Gly Ser 
                245             


<210>  3
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  3

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  4
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  4

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  5
<211>  193
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
1               5                   10                  15      


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
            20                  25                  30          


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
        35                  40                  45              


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
    50                  55                  60                  


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
65                  70                  75                  80  


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
                85                  90                  95      


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
            100                 105                 110         


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
        115                 120                 125             


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
    130                 135                 140                 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
145                 150                 155                 160 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
                165                 170                 175     


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
            180                 185                 190         


Ala 
    


<210>  6
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  6

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  7
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Leu Val Pro Arg Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     


Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
            260                 265                 270         


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
        275                 280                 285             


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
    290                 295                 300                 


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
305                 310                 315                 320 


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
                325                 330                 335     


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
            340                 345                 350         


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
        355                 360                 365             


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
    370                 375                 380                 


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
385                 390                 395                 400 


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
                405                 410                 415     


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
            420                 425                 430         


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
        435                 440                 445             


Ala 
    


<210>  8
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Leu Val Pro Arg Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
        275                 280                 285             


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
    290                 295                 300                 


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
305                 310                 315                 320 


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
                325                 330                 335     


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
            340                 345                 350         


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
        355                 360                 365             


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
    370                 375                 380                 


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
385                 390                 395                 400 


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
                405                 410                 415     


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
            420                 425                 430         


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
        435                 440                 445             


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
    450                 455                 460                 


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
465                 470                 475                 480 


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
                485                 490                 495     


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
            500                 505                 510         


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
        515                 520                 525             


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
    530                 535                 540                 


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
545                 550                 555                 560 


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
                565                 570                 575     


Ala Cys Val Pro Cys Arg Val Arg Ser 
            580                 585 


<210>  9
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
            260                 265                 270         


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
        275                 280                 285             


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
    290                 295                 300                 


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
305                 310                 315                 320 


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
                325                 330                 335     


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
            340                 345                 350         


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
        355                 360                 365             


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
    370                 375                 380                 


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
385                 390                 395                 400 


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
                405                 410                 415     


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
            420                 425                 430         


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
        435                 440                 445             


Tyr Leu Ser Ser Ala His His His His His His 
    450                 455                 


<210>  10
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro 
1               5                   10                  15      


Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr 
            20                  25                  30          


Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val Ser His Val 
        35                  40                  45              


Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr Gly Gln Glu 
    50                  55                  60                  


Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val Gln Phe Trp 
65                  70                  75                  80  


Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe Trp Val Glu 
                85                  90                  95      


Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr 
            100                 105                 110         


Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His Ile Lys Val 
        115                 120                 125             


Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val Ser Glu Glu 
    130                 135                 140                 


Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr Thr Asn Trp 
145                 150                 155                 160 


Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser Gly Val Leu 
                165                 170                 175     


Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys Pro Ser Glu 
            180                 185                 190         


Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser 
        195                 200                 205             


Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro Val Cys Val 
    210                 215                 220                 


Pro Pro Glu Val Leu Pro Gln Ala Gly Leu Leu Ser Gly Arg Ser Asp 
225                 230                 235                 240 


Asn His Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Trp Glu Leu Glu Lys 
            260                 265                 270         


Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu 
        275                 280                 285             


Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp 
    290                 295                 300                 


Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr 
305                 310                 315                 320 


Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys 
                325                 330                 335     


Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu 
            340                 345                 350         


Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr 
        355                 360                 365             


Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser 
    370                 375                 380                 


Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu 
                405                 410                 415     


Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser 
            420                 425                 430         


Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu 
        435                 440                 445             


Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn 
    450                 455                 460                 


Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
465                 470                 475                 480 


Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser 
                485                 490                 495     


Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
            500                 505                 510         


Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr 
        515                 520                 525             


Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser 
    530                 535                 540                 


Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp 
545                 550                 555                 560 


Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg 
                565                 570                 575     


Val Arg Ser 
            


<210>  11
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Gly Ala Ser Gly Pro 
        195                 200                 205             


Gly Asp Gly Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser 
    210                 215                 220                 


Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys 
225                 230                 235                 240 


Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val 
                245                 250                 255     


Ser His Val Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr 
            260                 265                 270         


Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val 
        275                 280                 285             


Gln Phe Trp Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe 
    290                 295                 300                 


Trp Val Glu Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile 
305                 310                 315                 320 


Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His 
                325                 330                 335     


Ile Lys Val Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val 
            340                 345                 350         


Ser Glu Glu Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr 
        355                 360                 365             


Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser 
    370                 375                 380                 


Gly Val Leu Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys 
385                 390                 395                 400 


Pro Ser Glu Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg 
                405                 410                 415     


Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro 
            420                 425                 430         


Val Cys Val Pro Pro Glu Val Leu Pro Gln Ala Leu Val Pro Arg Gly 
        435                 440                 445             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Trp Glu Leu Glu Lys Asp 
465                 470                 475                 480 


Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr 
                485                 490                 495     


Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr 
            500                 505                 510         


Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile 
        515                 520                 525             


Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly 
    530                 535                 540                 


Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn 
545                 550                 555                 560 


Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe 
                565                 570                 575     


Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp 
            580                 585                 590         


Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser 
        595                 600                 605             


Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser 
    610                 615                 620                 


Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val 
625                 630                 635                 640 


Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro 
                645                 650                 655     


Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr 
            660                 665                 670         


Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
        675                 680                 685             


Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp 
    690                 695                 700                 


Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys 
705                 710                 715                 720 


Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu 
                725                 730                 735     


Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr 
            740                 745                 750         


Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg 
        755                 760                 765             


Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val 
    770                 775                 780                 


Arg Ser 
785     


<210>  12
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Gly Ala Ser Gly Pro 
        195                 200                 205             


Gly Asp Gly Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser 
    210                 215                 220                 


Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys 
225                 230                 235                 240 


Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val 
                245                 250                 255     


Ser His Val Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr 
            260                 265                 270         


Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val 
        275                 280                 285             


Gln Phe Trp Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe 
    290                 295                 300                 


Trp Val Glu Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile 
305                 310                 315                 320 


Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His 
                325                 330                 335     


Ile Lys Val Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val 
            340                 345                 350         


Ser Glu Glu Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr 
        355                 360                 365             


Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser 
    370                 375                 380                 


Gly Val Leu Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys 
385                 390                 395                 400 


Pro Ser Glu Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg 
                405                 410                 415     


Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro 
            420                 425                 430         


Val Cys Val Pro Pro Glu Val Leu Pro Gln Ala Gly Leu Leu Ser Gly 
        435                 440                 445             


Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Trp Glu 
465                 470                 475                 480 


Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala 
                485                 490                 495     


Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp 
            500                 505                 510         


Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys 
        515                 520                 525             


Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr 
    530                 535                 540                 


Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His 
545                 550                 555                 560 


Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys 
                565                 570                 575     


Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe 
            580                 585                 590         


Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile 
        595                 600                 605             


Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met 
    610                 615                 620                 


Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu 
625                 630                 635                 640 


Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu 
                645                 650                 655     


Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys 
            660                 665                 670         


Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro 
        675                 680                 685             


Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val 
    690                 695                 700                 


Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr 
705                 710                 715                 720 


Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met 
                725                 730                 735     


Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu 
            740                 745                 750         


Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln 
        755                 760                 765             


Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val 
    770                 775                 780                 


Pro Cys Arg Val Arg Ser 
785                 790 


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
1               5                   10  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Leu Val Pro Arg Gly Ser 
1               5       


<210>  15
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Leu Val Pro Arg Gly Ser Gly Leu Leu Ser Gly Arg Ser Asp 
                245                 250                 255     


Asn His Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu 
        275                 280                 285             


Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr 
    290                 295                 300                 


Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp 
305                 310                 315                 320 


His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 
                325                 330                 335     


Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr 
            340                 345                 350         


Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu 
        355                 360                 365             


Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
    370                 375                 380                 


Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His 
385                 390                 395                 400 


Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 
                405                 410                 415     


Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 
            420                 425                 430         


Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu 
        435                 440                 445             


Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly 
    450                 455                 460                 


Tyr Leu Ser Ser Ala 
465                 


<210>  16
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro 
1               5                   10                  15      


Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr 
            20                  25                  30          


Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val Ser His Val 
        35                  40                  45              


Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr Gly Gln Glu 
    50                  55                  60                  


Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val Gln Phe Trp 
65                  70                  75                  80  


Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe Trp Val Glu 
                85                  90                  95      


Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr 
            100                 105                 110         


Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His Ile Lys Val 
        115                 120                 125             


Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val Ser Glu Glu 
    130                 135                 140                 


Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr Thr Asn Trp 
145                 150                 155                 160 


Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser Gly Val Leu 
                165                 170                 175     


Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys Pro Ser Glu 
            180                 185                 190         


Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser 
        195                 200                 205             


Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro Val Cys Val 
    210                 215                 220                 


Pro Pro Glu Val Leu Pro Gln Ala Gly Leu Leu Ser Gly Arg Ser Asp 
225                 230                 235                 240 


Asn His Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Leu Leu Ser 
                245                 250                 255     


Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser Arg Val 
            260                 265                 270         


Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu 
        275                 280                 285             


Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys 
    290                 295                 300                 


His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg 
305                 310                 315                 320 


Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys 
                325                 330                 335     


Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly 
            340                 345                 350         


Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu 
        355                 360                 365             


Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala 
    370                 375                 380                 


Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp 
385                 390                 395                 400 


Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His 
                405                 410                 415     


Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro 
            420                 425                 430         


Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr 
        435                 440                 445             


Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    450                 455                 460             


<210>  17
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro 
1               5                   10                  15      


Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr 
            20                  25                  30          


Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val Ser His Val 
        35                  40                  45              


Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr Gly Gln Glu 
    50                  55                  60                  


Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val Gln Phe Trp 
65                  70                  75                  80  


Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe Trp Val Glu 
                85                  90                  95      


Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr 
            100                 105                 110         


Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His Ile Lys Val 
        115                 120                 125             


Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val Ser Glu Glu 
    130                 135                 140                 


Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr Thr Asn Trp 
145                 150                 155                 160 


Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser Gly Val Leu 
                165                 170                 175     


Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys Pro Ser Glu 
            180                 185                 190         


Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser 
        195                 200                 205             


Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro Val Cys Val 
    210                 215                 220                 


Pro Pro Glu Val Leu Pro Gln Ala Leu Val Pro Arg Gly Ser Leu Val 
225                 230                 235                 240 


Pro Arg Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln 
            260                 265                 270         


Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg 
        275                 280                 285             


Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu 
    290                 295                 300                 


Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu 
305                 310                 315                 320 


Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser 
                325                 330                 335     


Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met 
            340                 345                 350         


Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr 
        355                 360                 365             


Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln 
    370                 375                 380                 


Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln 
385                 390                 395                 400 


Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly 
                405                 410                 415     


Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His 
            420                 425                 430         


Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu 
        435                 440                 445             


Ser Ser Ala 
    450     


<210>  18
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Cys Cys Val Glu Lys Thr Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro 
1               5                   10                  15      


Leu Gly Pro Arg Asn Leu Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr 
            20                  25                  30          


Glu Cys Ser Trp Gln Tyr Asp Gly Pro Glu Asp Asn Val Ser His Val 
        35                  40                  45              


Leu Trp Cys Cys Phe Val Pro Pro Asn His Thr His Thr Gly Gln Glu 
    50                  55                  60                  


Arg Cys Arg Tyr Phe Ser Ser Gly Pro Asp Arg Thr Val Gln Phe Trp 
65                  70                  75                  80  


Glu Gln Asp Gly Ile Pro Val Leu Ser Lys Val Asn Phe Trp Val Glu 
                85                  90                  95      


Ser Arg Leu Gly Asn Arg Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr 
            100                 105                 110         


Leu Tyr Asn Trp Thr Lys Thr Thr Pro Pro Leu Gly His Ile Lys Val 
        115                 120                 125             


Ser Gln Ser His Arg Gln Leu Arg Met Asp Trp Asn Val Ser Glu Glu 
    130                 135                 140                 


Ala Gly Ala Glu Val Gln Phe Arg Arg Arg Met Pro Thr Thr Asn Trp 
145                 150                 155                 160 


Thr Leu Gly Asp Cys Gly Pro Gln Val Asn Ser Gly Ser Gly Val Leu 
                165                 170                 175     


Gly Asp Ile Arg Gly Ser Met Ser Glu Ser Cys Leu Cys Pro Ser Glu 
            180                 185                 190         


Asn Met Ala Gln Glu Ile Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser 
        195                 200                 205             


Gly Ala Pro Gly Gly Pro Trp Ser Asp Trp Ser Met Pro Val Cys Val 
    210                 215                 220                 


Pro Pro Glu Val Leu Pro Gln Ala Leu Val Pro Arg Gly Ser Leu Val 
225                 230                 235                 240 


Pro Arg Gly Ser Leu Val Pro Arg Gly Ser Gly Leu Leu Ser Gly Arg 
                245                 250                 255     


Ser Asp Asn His Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Leu 
            260                 265                 270         


Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
    290                 295                 300                 


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
305                 310                 315                 320 


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
                325                 330                 335     


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
            340                 345                 350         


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
        355                 360                 365             


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
    370                 375                 380                 


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
385                 390                 395                 400 


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
                405                 410                 415     


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
            420                 425                 430         


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
        435                 440                 445             


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
    450                 455                 460                 


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
465                 470                 475                 480 


Ala 
    


<210>  19
<211>  639
<212>  PRT
<213>  Homo Sapiens

<400>  19

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Asn Pro Pro Gln Pro Gln Val Arg Phe Ser Val Glu Gln 
    210                 215                 220                 


Leu Gly Gln Asp Gly Arg Arg Arg Leu Thr Leu Lys Glu Gln Pro Thr 
225                 230                 235                 240 


Gln Leu Glu Leu Pro Glu Gly Cys Gln Gly Leu Ala Pro Gly Thr Glu 
                245                 250                 255     


Val Thr Tyr Arg Leu Gln Leu His Met Leu Ser Cys Pro Cys Lys Ala 
            260                 265                 270         


Lys Ala Thr Arg Thr Leu His Leu Gly Lys Met Pro Tyr Leu Ser Gly 
        275                 280                 285             


Ala Ala Tyr Asn Val Ala Val Ile Ser Ser Asn Gln Phe Gly Pro Gly 
    290                 295                 300                 


Leu Asn Gln Thr Trp His Ile Pro Ala Asp Thr His Thr Glu Pro Val 
305                 310                 315                 320 


Ala Leu Asn Ile Ser Val Gly Thr Asn Gly Thr Thr Met Tyr Trp Pro 
                325                 330                 335     


Ala Arg Ala Gln Ser Met Thr Tyr Cys Ile Glu Trp Gln Pro Val Gly 
            340                 345                 350         


Gln Asp Gly Gly Leu Ala Thr Cys Ser Leu Thr Ala Pro Gln Asp Pro 
        355                 360                 365             


Asp Pro Ala Gly Met Ala Thr Tyr Ser Trp Ser Arg Glu Ser Gly Ala 
    370                 375                 380                 


Met Gly Gln Glu Lys Cys Tyr Tyr Ile Thr Ile Phe Ala Ser Ala His 
385                 390                 395                 400 


Pro Glu Lys Leu Thr Leu Trp Ser Thr Val Leu Ser Thr Tyr His Phe 
                405                 410                 415     


Gly Gly Asn Ala Ser Ala Ala Gly Thr Pro His His Val Ser Val Lys 
            420                 425                 430         


Asn His Ser Leu Asp Ser Val Ser Val Asp Trp Ala Pro Ser Leu Leu 
        435                 440                 445             


Ser Thr Cys Pro Gly Val Leu Lys Glu Tyr Val Val Arg Cys Arg Asp 
    450                 455                 460                 


Glu Asp Ser Lys Gln Val Ser Glu His Pro Val Gln Pro Thr Glu Thr 
465                 470                 475                 480 


Gln Val Thr Leu Ser Gly Leu Arg Ala Gly Val Ala Tyr Thr Val Gln 
                485                 490                 495     


Val Arg Ala Asp Thr Ala Trp Leu Arg Gly Val Trp Ser Gln Pro Gln 
            500                 505                 510         


Arg Phe Ser Ile Glu Val Gln Val Ser Asp Trp Leu Ile Phe Phe Ala 
        515                 520                 525             


Ser Leu Gly Ser Phe Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr 
    530                 535                 540                 


Leu Gly Leu Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr 
545                 550                 555                 560 


Pro Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp 
                565                 570                 575     


Gln Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu 
            580                 585                 590         


Ala Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro 
        595                 600                 605             


Leu Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp 
    610                 615                 620                 


Thr Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
625                 630                 635                 


<210>  20
<211>  719
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Phe Leu Val Glu Pro Leu Asn Gln Gly Gly Arg 
                245                 250                 255     


Arg Arg Leu Thr Met Gln Gly Gln Ser Pro Gln Leu Ala Val Pro Glu 
            260                 265                 270         


Gly Cys Arg Gly Arg Pro Gly Ala Gln Val Lys Lys His Leu Val Leu 
        275                 280                 285             


Val Arg Met Leu Ser Cys Arg Cys Gln Ala Gln Thr Ser Lys Thr Val 
    290                 295                 300                 


Pro Leu Gly Lys Lys Leu Asn Leu Ser Gly Ala Thr Tyr Asp Leu Asn 
305                 310                 315                 320 


Val Leu Ala Lys Thr Arg Phe Gly Arg Ser Thr Ile Gln Lys Trp His 
                325                 330                 335     


Leu Pro Ala Gln Glu Leu Thr Glu Thr Arg Ala Leu Asn Val Ser Val 
            340                 345                 350         


Gly Gly Asn Met Thr Ser Met Gln Trp Ala Ala Gln Ala Pro Gly Thr 
        355                 360                 365             


Thr Tyr Cys Leu Glu Trp Gln Pro Trp Phe Gln His Arg Asn His Thr 
    370                 375                 380                 


His Cys Thr Leu Ile Val Pro Glu Glu Glu Asp Pro Ala Lys Met Val 
385                 390                 395                 400 


Thr His Ser Trp Ser Ser Lys Pro Thr Leu Glu Gln Glu Glu Cys Tyr 
                405                 410                 415     


Arg Ile Thr Val Phe Ala Ser Lys Asn Pro Lys Asn Pro Met Leu Trp 
            420                 425                 430         


Ala Thr Val Leu Ser Ser Tyr Tyr Phe Gly Gly Asn Ala Ser Arg Ala 
        435                 440                 445             


Gly Thr Pro Arg His Val Ser Val Arg Asn Gln Thr Gly Asp Ser Val 
    450                 455                 460                 


Ser Val Glu Trp Thr Ala Ser Gln Leu Ser Thr Cys Pro Gly Val Leu 
465                 470                 475                 480 


Thr Gln Tyr Val Val Arg Cys Glu Ala Glu Asp Gly Ala Trp Glu Ser 
                485                 490                 495     


Glu Trp Leu Val Pro Pro Thr Lys Thr Gln Val Thr Leu Asp Gly Leu 
            500                 505                 510         


Arg Ser Arg Val Met Tyr Lys Val Gln Val Arg Ala Asp Thr Ala Arg 
        515                 520                 525             


Leu Pro Gly Ala Trp Ser His Pro Gln Arg Phe Ser Phe Glu Val Gln 
    530                 535                 540                 


Ile Ser Arg Leu Ser Ile Ile Phe Ala Ser Leu Gly Ser Phe Ala Ser 
545                 550                 555                 560 


Val Leu Leu Val Gly Ser Leu Gly Tyr Ile Gly Leu Asn Arg Ala Ala 
                565                 570                 575     


Trp His Leu Cys Pro Pro Leu Pro Thr Pro Cys Gly Ser Thr Ala Val 
            580                 585                 590         


Glu Phe Pro Gly Ser Gln Gly Lys Gln Ala Trp Gln Trp Cys Asn Pro 
        595                 600                 605             


Glu Asp Phe Pro Glu Val Leu Tyr Pro Arg Asp Ala Leu Val Val Glu 
    610                 615                 620                 


Met Pro Gly Asp Arg Gly Asp Gly Thr Glu Ser Pro Gln Ala Ala Pro 
625                 630                 635                 640 


Glu Cys Ala Leu Asp Thr Arg Arg Pro Leu Glu Thr Gln Arg Gln Arg 
                645                 650                 655     


Gln Val Gln Ala Leu Ser Glu Ala Arg Arg Leu Gly Leu Ala Arg Glu 
            660                 665                 670         


Asp Cys Pro Arg Gly Asp Leu Ala His Val Thr Leu Pro Leu Leu Leu 
        675                 680                 685             


Gly Gly Val Thr Gln Gly Ala Ser Val Leu Asp Asp Leu Trp Arg Thr 
    690                 695                 700                 


His Lys Thr Ala Glu Pro Gly Pro Pro Thr Leu Gly Gln Glu Ala 
705                 710                 715                 


<210>  21
<211>  839
<212>  PRT
<213>  Homo Sapiens

<400>  21

Lys Ile Asp Ala Cys Lys Arg Gly Asp Val Thr Val Lys Pro Ser His 
1               5                   10                  15      


Val Ile Leu Leu Gly Ser Thr Val Asn Ile Thr Cys Ser Leu Lys Pro 
            20                  25                  30          


Arg Gln Gly Cys Phe His Tyr Ser Arg Arg Asn Lys Leu Ile Leu Tyr 
        35                  40                  45              


Lys Phe Asp Arg Arg Ile Asn Phe His His Gly His Ser Leu Asn Ser 
    50                  55                  60                  


Gln Val Thr Gly Leu Pro Leu Gly Thr Thr Leu Phe Val Cys Lys Leu 
65                  70                  75                  80  


Ala Cys Ile Asn Ser Asp Glu Ile Gln Ile Cys Gly Ala Glu Ile Phe 
                85                  90                  95      


Val Gly Val Ala Pro Glu Gln Pro Gln Asn Leu Ser Cys Ile Gln Lys 
            100                 105                 110         


Gly Glu Gln Gly Thr Val Ala Cys Thr Trp Glu Arg Gly Arg Asp Thr 
        115                 120                 125             


His Leu Tyr Thr Glu Tyr Thr Leu Gln Leu Ser Gly Pro Lys Asn Leu 
    130                 135                 140                 


Thr Trp Gln Lys Gln Cys Lys Asp Ile Tyr Cys Asp Tyr Leu Asp Phe 
145                 150                 155                 160 


Gly Ile Asn Leu Thr Pro Glu Ser Pro Glu Ser Asn Phe Thr Ala Lys 
                165                 170                 175     


Val Thr Ala Val Asn Ser Leu Gly Ser Ser Ser Ser Leu Pro Ser Thr 
            180                 185                 190         


Phe Thr Phe Leu Asp Ile Val Arg Pro Leu Pro Pro Trp Asp Ile Arg 
        195                 200                 205             


Ile Lys Phe Gln Lys Ala Ser Val Ser Arg Cys Thr Leu Tyr Trp Arg 
    210                 215                 220                 


Asp Glu Gly Leu Val Leu Leu Asn Arg Leu Arg Tyr Arg Pro Ser Asn 
225                 230                 235                 240 


Ser Arg Leu Trp Asn Met Val Asn Val Thr Lys Ala Lys Gly Arg His 
                245                 250                 255     


Asp Leu Leu Asp Leu Lys Pro Phe Thr Glu Tyr Glu Phe Gln Ile Ser 
            260                 265                 270         


Ser Lys Leu His Leu Tyr Lys Gly Ser Trp Ser Asp Trp Ser Glu Ser 
        275                 280                 285             


Leu Arg Ala Gln Thr Pro Glu Glu Glu Pro Thr Gly Met Leu Asp Val 
    290                 295                 300                 


Trp Tyr Met Lys Arg His Ile Asp Tyr Ser Arg Gln Gln Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Lys Asn Leu Ser Val Ser Glu Ala Arg Gly Lys Ile Leu His 
                325                 330                 335     


Tyr Gln Val Thr Leu Gln Glu Leu Thr Gly Gly Lys Ala Met Thr Gln 
            340                 345                 350         


Asn Ile Thr Gly His Thr Ser Trp Thr Thr Val Ile Pro Arg Thr Gly 
        355                 360                 365             


Asn Trp Ala Val Ala Val Ser Ala Ala Asn Ser Lys Gly Ser Ser Leu 
    370                 375                 380                 


Pro Thr Arg Ile Asn Ile Met Asn Leu Cys Glu Ala Gly Leu Leu Ala 
385                 390                 395                 400 


Pro Arg Gln Val Ser Ala Asn Ser Glu Gly Met Asp Asn Ile Leu Val 
                405                 410                 415     


Thr Trp Gln Pro Pro Arg Lys Asp Pro Ser Ala Val Gln Glu Tyr Val 
            420                 425                 430         


Val Glu Trp Arg Glu Leu His Pro Gly Gly Asp Thr Gln Val Pro Leu 
        435                 440                 445             


Asn Trp Leu Arg Ser Arg Pro Tyr Asn Val Ser Ala Leu Ile Ser Glu 
    450                 455                 460                 


Asn Ile Lys Ser Tyr Ile Cys Tyr Glu Ile Arg Val Tyr Ala Leu Ser 
465                 470                 475                 480 


Gly Asp Gln Gly Gly Cys Ser Ser Ile Leu Gly Asn Ser Lys His Lys 
                485                 490                 495     


Ala Pro Leu Ser Gly Pro His Ile Asn Ala Ile Thr Glu Glu Lys Gly 
            500                 505                 510         


Ser Ile Leu Ile Ser Trp Asn Ser Ile Pro Val Gln Glu Gln Met Gly 
        515                 520                 525             


Cys Leu Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser Asn Ser 
    530                 535                 540                 


Gln Pro Gln Leu Cys Glu Ile Pro Tyr Arg Val Ser Gln Asn Ser His 
545                 550                 555                 560 


Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met Thr 
                565                 570                 575     


Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg Glu Phe 
            580                 585                 590         


Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro Ser Ile 
        595                 600                 605             


Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe Gln 
    610                 615                 620                 


Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser 
625                 630                 635                 640 


Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro 
                645                 650                 655     


Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp 
            660                 665                 670         


Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu 
        675                 680                 685             


His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro 
    690                 695                 700                 


Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met 
705                 710                 715                 720 


Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu 
                725                 730                 735     


Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser 
            740                 745                 750         


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
        755                 760                 765             


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
    770                 775                 780                 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
785                 790                 795                 800 


Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro 
                805                 810                 815     


Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met 
            820                 825                 830         


Arg Cys Asp Ser Leu Met Leu 
        835                 


<210>  22
<211>  851
<212>  PRT
<213>  Mus musculus

<400>  22

Asn Ile Asp Val Cys Lys Leu Gly Thr Val Thr Val Gln Pro Ala Pro 
1               5                   10                  15      


Val Ile Pro Leu Gly Ser Ala Ala Asn Ile Ser Cys Ser Leu Asn Pro 
            20                  25                  30          


Lys Gln Gly Cys Ser His Tyr Pro Ser Ser Asn Glu Leu Ile Leu Leu 
        35                  40                  45              


Lys Phe Val Asn Asp Val Leu Val Glu Asn Leu His Gly Lys Lys Val 
    50                  55                  60                  


His Asp His Thr Gly His Ser Ser Thr Phe Gln Val Thr Asn Leu Ser 
65                  70                  75                  80  


Leu Gly Met Thr Leu Phe Val Cys Lys Leu Asn Cys Ser Asn Ser Gln 
                85                  90                  95      


Lys Lys Pro Pro Val Pro Val Cys Gly Val Glu Ile Ser Val Gly Val 
            100                 105                 110         


Ala Pro Glu Pro Pro Gln Asn Ile Ser Cys Val Gln Glu Gly Glu Asn 
        115                 120                 125             


Gly Thr Val Ala Cys Ser Trp Asn Ser Gly Lys Val Thr Tyr Leu Lys 
    130                 135                 140                 


Thr Asn Tyr Thr Leu Gln Leu Ser Gly Pro Asn Asn Leu Thr Cys Gln 
145                 150                 155                 160 


Lys Gln Cys Phe Ser Asp Asn Arg Gln Asn Cys Asn Arg Leu Asp Leu 
                165                 170                 175     


Gly Ile Asn Leu Ser Pro Asp Leu Ala Glu Ser Arg Phe Ile Val Arg 
            180                 185                 190         


Val Thr Ala Ile Asn Asp Leu Gly Asn Ser Ser Ser Leu Pro His Thr 
        195                 200                 205             


Phe Thr Phe Leu Asp Ile Val Ile Pro Leu Pro Pro Trp Asp Ile Arg 
    210                 215                 220                 


Ile Asn Phe Leu Asn Ala Ser Gly Ser Arg Gly Thr Leu Gln Trp Glu 
225                 230                 235                 240 


Asp Glu Gly Gln Val Val Leu Asn Gln Leu Arg Tyr Gln Pro Leu Asn 
                245                 250                 255     


Ser Thr Ser Trp Asn Met Val Asn Ala Thr Asn Ala Lys Gly Lys Tyr 
            260                 265                 270         


Asp Leu Arg Asp Leu Arg Pro Phe Thr Glu Tyr Glu Phe Gln Ile Ser 
        275                 280                 285             


Ser Lys Leu His Leu Ser Gly Gly Ser Trp Ser Asn Trp Ser Glu Ser 
    290                 295                 300                 


Leu Arg Thr Arg Thr Pro Glu Glu Glu Pro Val Gly Ile Leu Asp Ile 
305                 310                 315                 320 


Trp Tyr Met Lys Gln Asp Ile Asp Tyr Asp Arg Gln Gln Ile Ser Leu 
                325                 330                 335     


Phe Trp Lys Ser Leu Asn Pro Ser Glu Ala Arg Gly Lys Ile Leu His 
            340                 345                 350         


Tyr Gln Val Thr Leu Gln Glu Val Thr Lys Lys Thr Thr Leu Gln Asn 
        355                 360                 365             


Thr Thr Arg His Thr Ser Trp Thr Arg Val Ile Pro Arg Thr Gly Ala 
    370                 375                 380                 


Trp Thr Ala Ser Val Ser Ala Ala Asn Ser Lys Gly Ala Ser Ala Pro 
385                 390                 395                 400 


Thr His Ile Asn Ile Val Asp Leu Cys Gly Thr Gly Leu Leu Ala Pro 
                405                 410                 415     


His Gln Val Ser Ala Lys Ser Glu Asn Met Asp Asn Ile Leu Val Thr 
            420                 425                 430         


Trp Gln Pro Pro Lys Lys Ala Asp Ser Ala Val Arg Glu Tyr Ile Val 
        435                 440                 445             


Glu Trp Arg Ala Leu Gln Pro Gly Ser Ile Thr Lys Phe Pro Pro His 
    450                 455                 460                 


Trp Leu Arg Ile Pro Pro Asp Asn Met Ser Ala Leu Ile Ser Glu Asn 
465                 470                 475                 480 


Ile Lys Pro Tyr Ile Cys Tyr Glu Ile Arg Val His Ala Leu Ser Glu 
                485                 490                 495     


Ser Gln Gly Gly Cys Ser Ser Ile Arg Gly Asp Ser Lys His Lys Ala 
            500                 505                 510         


Pro Val Ser Gly Pro His Ile Thr Ala Ile Thr Glu Lys Lys Glu Arg 
        515                 520                 525             


Leu Phe Ile Ser Trp Thr His Ile Pro Phe Pro Glu Gln Arg Gly Cys 
    530                 535                 540                 


Ile Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser Thr Ala Gln 
545                 550                 555                 560 


Pro Glu Leu Cys Glu Ile Gln Tyr Arg Arg Ser Gln Asn Ser His Pro 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met Thr Ala 
            580                 585                 590         


Val Thr Ala Ala Gly Glu Ser Pro Gln Gly Asn Glu Arg Glu Phe Cys 
        595                 600                 605             


Pro Gln Gly Lys Ala Asn Trp Lys Ala Phe Val Ile Ser Ser Ile Cys 
    610                 615                 620                 


Ile Ala Ile Ile Thr Val Gly Thr Phe Ser Ile Arg Tyr Phe Arg Gln 
625                 630                 635                 640 


Lys Ala Phe Thr Leu Leu Ser Thr Leu Lys Pro Gln Trp Tyr Ser Arg 
                645                 650                 655     


Thr Ile Pro Asp Pro Ala Asn Ser Thr Trp Val Lys Lys Tyr Pro Ile 
            660                 665                 670         


Leu Glu Glu Lys Ile Gln Leu Pro Thr Asp Asn Leu Leu Met Ala Trp 
        675                 680                 685             


Pro Thr Pro Glu Glu Pro Glu Pro Leu Ile Ile His Glu Val Leu Tyr 
    690                 695                 700                 


His Met Ile Pro Val Val Arg Gln Pro Tyr Tyr Phe Lys Arg Gly Gln 
705                 710                 715                 720 


Gly Phe Gln Gly Tyr Ser Thr Ser Lys Gln Asp Ala Met Tyr Ile Ala 
                725                 730                 735     


Asn Pro Gln Ala Thr Gly Thr Leu Thr Ala Glu Thr Arg Gln Leu Val 
            740                 745                 750         


Asn Leu Tyr Lys Val Leu Glu Ser Arg Asp Pro Asp Ser Lys Leu Ala 
        755                 760                 765             


Asn Leu Thr Ser Pro Leu Thr Val Thr Pro Val Asn Tyr Leu Pro Ser 
    770                 775                 780                 


His Glu Gly Tyr Leu Pro Ser Asn Ile Glu Asp Leu Ser Pro His Glu 
785                 790                 795                 800 


Ala Asp Pro Thr Asp Ser Phe Asp Leu Glu His Gln His Ile Ser Leu 
                805                 810                 815     


Ser Ile Phe Ala Ser Ser Ser Leu Arg Pro Leu Ile Phe Gly Gly Glu 
            820                 825                 830         


Arg Leu Thr Leu Asp Arg Leu Lys Met Gly Tyr Asp Ser Leu Met Ser 
        835                 840                 845             


Asn Glu Ala 
    850     


<210>  23
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ala Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  24
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  24

Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu Met 
            20                  25                  30          


Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu Lys 
        35                  40                  45              


Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala Thr 
    50                  55                  60                  


Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu Arg 
65                  70                  75                  80  


His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp Ala 
                85                  90                  95      


Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys Gly 
            100                 105                 110         


Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr Val 
        115                 120                 125             


Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile Ser 
    130                 135                 140                 


Thr Ser Pro Gln 
145             


<210>  25
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  25

His Gly Thr Val Ile Glu Ser Leu Glu Ser Leu Asn Asn Tyr Phe Asn 
1               5                   10                  15      


Ser Ser Gly Ile Asp Val Glu Glu Lys Ser Leu Phe Leu Asp Ile Trp 
            20                  25                  30          


Arg Asn Trp Gln Lys Asp Gly Asp Met Lys Ile Leu Gln Ser Gln Ile 
        35                  40                  45              


Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val Leu Lys Asp Asn Gln Ala 
    50                  55                  60                  


Ile Ser Asn Asn Ile Ser Val Ile Glu Ser His Leu Ile Thr Thr Phe 
65                  70                  75                  80  


Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala Phe Met Ser Ile Ala Lys 
                85                  90                  95      


Phe Glu Val Asn Asn Pro Gln Val Gln Arg Gln Ala Phe Asn Glu Leu 
            100                 105                 110         


Ile Arg Val Val His Gln Leu Leu Pro Glu Ser Ser Leu Arg Lys Arg 
        115                 120                 125             


Lys Arg Ser Arg Cys 
    130             


<210>  26
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  26

Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Gln Gly Arg Arg Ala Ser Gln 
    130                 135                 140             


<210>  27
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  27

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  28
<211>  214
<212>  PRT
<213>  Mus musculus

<400>  28

Ala Val Lys Asn Cys Ser His Leu Glu Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Val Ser Cys Met Trp Ser His Glu Glu Ala Leu Asn Val Thr Thr 
            20                  25                  30          


Cys His Val His Ala Lys Ser Asn Leu Arg His Trp Asn Lys Thr Cys 
        35                  40                  45              


Glu Leu Thr Leu Val Arg Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ser Phe Pro Glu Ser Gln Ser Leu Thr Ser Val Asp Leu Leu Asp 
65                  70                  75                  80  


Ile Asn Val Val Cys Trp Glu Glu Lys Gly Trp Arg Arg Val Lys Thr 
                85                  90                  95      


Cys Asp Phe His Pro Phe Asp Asn Leu Arg Leu Val Ala Pro His Ser 
            100                 105                 110         


Leu Gln Val Leu His Ile Asp Thr Gln Arg Cys Asn Ile Ser Trp Lys 
        115                 120                 125             


Val Ser Gln Val Ser His Tyr Ile Glu Pro Tyr Leu Glu Phe Glu Ala 
    130                 135                 140                 


Arg Arg Arg Leu Leu Gly His Ser Trp Glu Asp Ala Ser Val Leu Ser 
145                 150                 155                 160 


Leu Lys Gln Arg Gln Gln Trp Leu Phe Leu Glu Met Leu Ile Pro Ser 
                165                 170                 175     


Thr Ser Tyr Glu Val Gln Val Arg Val Lys Ala Gln Arg Asn Asn Thr 
            180                 185                 190         


Gly Thr Trp Ser Pro Trp Ser Gln Pro Leu Thr Phe Arg Thr Arg Pro 
        195                 200                 205             


Ala Asp Pro Met Lys Glu 
    210                 


<210>  29
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  29

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  30
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  30

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser 
    50                  55                  60                  


Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr 
65                  70                  75                  80  


Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu 
                85                  90                  95      


Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys 
            100                 105                 110         


Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile 
        115                 120                 125             


Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys 
    130                 135                 140                 


Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val 
145                 150                 155                 160 


Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly 
                165                 170                 175     


Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr 
            180                 185                 190         


Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe 
        195                 200                 205             


Val Leu Thr Met Glu Tyr Lys 
    210                 215 


<210>  31
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  31

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


<210>  32
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  32

Trp Ser Ser Lys Val Leu Met Ser Ser Ala Asn Glu Asp Ile Lys Ala 
1               5                   10                  15      


Asp Leu Ile Leu Thr Ser Thr Ala Pro Glu His Leu Ser Ala Pro Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Ile Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Ala Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Arg Tyr Lys Val Ser Asp Asn Asn Thr Phe Gln Glu Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Lys Glu Ile Thr Ser Gly Cys Gln Ile Gln 
                85                  90                  95      


Lys Glu Asp Ile Gln Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Gln Lys Pro Gln Arg Arg Ala Val Gln Lys Leu Asn Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Arg Ala Pro Glu Asn Leu Thr Leu Ser Asn Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Arg Trp Lys Ser Arg His Ile Lys Glu Arg 
145                 150                 155                 160 


Cys Leu Gln Tyr Leu Val Gln Tyr Arg Ser Asn Arg Asp Arg Ser Trp 
                165                 170                 175     


Thr Glu Leu Ile Val Asn His Glu Pro Arg Phe Ser Leu Pro Ser Val 
            180                 185                 190         


Asp Glu Leu Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Tyr Asn Pro 
        195                 200                 205             


Ile Cys Gly Ser Ser Gln Gln Trp Ser Lys Trp Ser Gln Pro Val His 
    210                 215                 220                 


Trp Gly Ser His Thr Val Glu Glu Asn Pro Ser Leu Phe Ala Leu Glu 
225                 230                 235                 240 


Ala 
    


<210>  33
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  33

Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro Thr 
1               5                   10                  15      


Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp Glu 
            20                  25                  30          


Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys Asn 
        35                  40                  45              


Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile Ser 
    50                  55                  60                  


His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn Ser 
65                  70                  75                  80  


Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala Tyr 
                85                  90                  95      


Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly Pro 
            100                 105                 110         


Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp Ile 
        115                 120                 125             


Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp Tyr 
    130                 135                 140                 


Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val Arg 
145                 150                 155                 160 


Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu Asp 
                165                 170                 175     


Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser Leu 
            180                 185                 190         


Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp Gly 
        195                 200                 205             


Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser 
    210                 215                 220                 


Ser Ile Lys Gly 
225             


<210>  34
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  34

Ala Leu Thr Ser Thr Glu Asp Pro Glu Pro Pro Ser Val Pro Val Pro 
1               5                   10                  15      


Thr Asn Val Leu Ile Lys Ser Tyr Asn Leu Asn Pro Val Val Cys Trp 
            20                  25                  30          


Glu Tyr Gln Asn Met Ser Gln Thr Pro Ile Phe Thr Val Gln Val Lys 
        35                  40                  45              


Val Tyr Ser Gly Ser Trp Thr Asp Ser Cys Thr Asn Ile Ser Asp His 
    50                  55                  60                  


Cys Cys Asn Ile Tyr Glu Gln Ile Met Tyr Pro Asp Val Ser Ala Trp 
65                  70                  75                  80  


Ala Arg Val Lys Ala Lys Val Gly Gln Lys Glu Ser Asp Tyr Ala Arg 
                85                  90                  95      


Ser Lys Glu Phe Leu Met Cys Leu Lys Gly Lys Val Gly Pro Pro Gly 
            100                 105                 110         


Leu Glu Ile Arg Arg Lys Lys Glu Glu Gln Leu Ser Val Leu Val Phe 
        115                 120                 125             


His Pro Glu Val Val Val Asn Gly Glu Ser Gln Gly Thr Met Phe Gly 
    130                 135                 140                 


Asp Gly Ser Thr Cys Tyr Thr Phe Asp Tyr Thr Val Tyr Val Glu His 
145                 150                 155                 160 


Asn Arg Ser Gly Glu Ile Leu His Thr Lys His Thr Val Glu Lys Glu 
                165                 170                 175     


Glu Cys Asn Glu Thr Leu Cys Glu Leu Asn Ile Ser Val Ser Thr Leu 
            180                 185                 190         


Asp Ser Arg Tyr Cys Ile Ser Val Asp Gly Ile Ser Ser Phe Trp Gln 
        195                 200                 205             


Val Arg Thr Glu Lys Ser Lys Asp Val Cys Ile Pro Pro Phe His Asp 
    210                 215                 220                 


Asp Arg Lys Asp Ser 
225                 


<210>  35
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  35

Ser Gln Leu Pro Ala Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala 
1               5                   10                  15      


Glu Gln Val Leu Ser Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg 
            20                  25                  30          


Pro Val Val Tyr Gln Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe 
        35                  40                  45              


Thr Ala Asp Ile Met Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala 
    50                  55                  60                  


Thr Glu Cys Asp Phe Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met 
65                  70                  75                  80  


Asp Phe Asn Val Thr Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His 
                85                  90                  95      


Ser Ala Trp Val Thr Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr 
            100                 105                 110         


Val Gly Pro Pro Glu Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu 
        115                 120                 125             


Ile Ile Arg Phe Ser Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala 
    130                 135                 140                 


Phe Phe Cys Tyr Tyr Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln 
145                 150                 155                 160 


Val Lys Gly Pro Phe Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys 
                165                 170                 175     


Pro Ser Arg Val Tyr Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn 
            180                 185                 190         


Lys Ser Asn Ile Phe Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr 
        195                 200                 205             


Glu Thr Met Ala Asp Ala Ser Thr Glu Leu Gln Gln 
    210                 215                 220 


<210>  36
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  36

Ala Ser Ser Pro Asp Ser Phe Ser Gln Leu Ala Ala Pro Leu Asn Pro 
1               5                   10                  15      


Arg Leu His Leu Tyr Asn Asp Glu Gln Ile Leu Thr Trp Glu Pro Ser 
            20                  25                  30          


Pro Ser Ser Asn Asp Pro Arg Pro Val Val Tyr Gln Val Glu Tyr Ser 
        35                  40                  45              


Phe Ile Asp Gly Ser Trp His Arg Leu Leu Glu Pro Asn Cys Thr Asp 
    50                  55                  60                  


Ile Thr Glu Thr Lys Cys Asp Leu Thr Gly Gly Gly Arg Leu Lys Leu 
65                  70                  75                  80  


Phe Pro His Pro Phe Thr Val Phe Leu Arg Val Arg Ala Lys Arg Gly 
                85                  90                  95      


Asn Leu Thr Ser Lys Trp Val Gly Leu Glu Pro Phe Gln His Tyr Glu 
            100                 105                 110         


Asn Val Thr Val Gly Pro Pro Lys Asn Ile Ser Val Thr Pro Gly Lys 
        115                 120                 125             


Gly Ser Leu Val Ile His Phe Ser Pro Pro Phe Asp Val Phe His Gly 
    130                 135                 140                 


Ala Thr Phe Gln Tyr Leu Val His Tyr Trp Glu Lys Ser Glu Thr Gln 
145                 150                 155                 160 


Gln Glu Gln Val Glu Gly Pro Phe Lys Ser Asn Ser Ile Val Leu Gly 
                165                 170                 175     


Asn Leu Lys Pro Tyr Arg Val Tyr Cys Leu Gln Thr Glu Ala Gln Leu 
            180                 185                 190         


Ile Leu Lys Asn Lys Lys Ile Arg Pro His Gly Leu Leu Ser Asn Val 
        195                 200                 205             


Ser Cys His Glu Thr Thr Ala Asn Ala Ser Ala Arg Leu Gln Gln Val 
    210                 215                 220                 


Ile Leu Ile Pro Leu Gly Ile Phe Ala Leu Leu Leu Gly Leu Thr Gly 
225                 230                 235                 240 


Ala Cys Phe Thr Leu Phe Leu Lys Tyr Gln Ser Arg Val Lys Tyr Trp 
                245                 250                 255     


Phe Gln Ala Pro Pro Asn Ile Pro Glu Gln Ile Glu Glu Tyr Leu Lys 
            260                 265                 270         


Asp Pro Asp Gln Phe Ile Leu Glu Val Leu Asp Lys Asp Gly Ser Pro 
        275                 280                 285             


Lys Glu Asp Ser Trp Asp Ser Val Ser Ile Ile Ser Ser Pro Glu Lys 
    290                 295                 300                 


Glu Arg Asp Asp Val Leu Gln Thr Pro 
305                 310             


<210>  37
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Cys Thr Gly 
        195     


<210>  38
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  39
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Cys Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 
1               5                   10                  15      


Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu His 
            20                  25                  30          


Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu Asp Gly 
        35                  40                  45              


Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys Ala Phe Val 
    50                  55                  60                  


Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys Trp Val Arg Val 
65                  70                  75                  80  


Ala Val Val Glu Tyr His Asp Gly Ser His Ala Tyr Ile Gly Leu Lys 
                85                  90                  95      


Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg Ile Ala Ser Gln Val Lys 
            100                 105                 110         


Tyr Ala Gly Ser Gln Val Ala Ser Thr Ser Glu Val Leu Lys Tyr Thr 
        115                 120                 125             


Leu Phe Gln Ile Phe Ser Lys Ile Asp Arg Pro Glu Ala Ser Arg Ile 
    130                 135                 140                 


Thr Leu Leu Leu Met Ala Ser Gln Glu Pro Gln Arg Met Ser Arg Asn 
145                 150                 155                 160 


Phe Val Arg Tyr Val Gln Gly Leu Lys Lys Lys Lys Val Ile Val Ile 
                165                 170                 175     


Pro Val Gly Ile Gly Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile 
            180                 185                 190         


Glu Lys Gln Ala Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp 
        195                 200                 205             


Glu Leu Glu Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys 
    210                 215                 220         


<210>  40
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Cys Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp 
1               5                   10                  15      


Glu Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu 
            20                  25                  30          


Pro Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg 
        35                  40                  45              


Val Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu 
    50                  55                  60                  


Pro Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu 
65                  70                  75                  80  


Ile Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile 
                85                  90                  95      


Leu Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro 
            100                 105                 110         


Leu Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu 
        115                 120                 125             


Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu 
    130                 135                 140                 


Asn Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln 
145                 150                 155                 160 


Met Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile 
                165                 170                 175     


Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile 
            180                 185                 190         


Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu 
        195                 200                 205             


Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala 
    210                 215                 220                 


Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn 
225                 230                 235                 240 


Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu 
                245                 250                 255     


Arg Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly 
            260                 265                 270         


Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn 
        275                 280                 285             


Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr 
    290                 295                 300                 


Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln 
305                 310                 315                 320 


Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser 
                325                 330                 335     


Ala Ile Gln Leu Gly Asn Tyr Lys 
            340                 


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Leu Arg Glu Leu His Leu Asp Asn Asn Cys 
1               5                   10  


<210>  42
<211>  584
<212>  PRT
<213>  Mus musculus

<400>  42

Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
1               5                   10                  15      


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
65                  70                  75                  80  


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            100                 105                 110         


Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe Lys 
        115                 120                 125             


Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu Gln 
145                 150                 155                 160 


Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu Ser 
                165                 170                 175     


Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val Ser 
            180                 185                 190         


Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe Pro 
    210                 215                 220                 


Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile Ser 
            260                 265                 270         


Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala His 
        275                 280                 285             


Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro Ala 
    290                 295                 300                 


Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys Lys 
            340                 345                 350         


Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro Ala 
        355                 360                 365             


Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly Glu 
385                 390                 395                 400 


Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly Arg 
            420                 425                 430         


Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro Cys 
        435                 440                 445             


Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly Ser 
465                 470                 475                 480 


Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser Asp 
            500                 505                 510         


Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln Leu 
    530                 535                 540                 


Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys Lys 
545                 550                 555                 560 


Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu Val 
                565                 570                 575     


Thr Arg Cys Lys Asp Ala Leu Ala 
            580                 


<210>  43
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  43

Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr 
1               5                   10                  15      


Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His 
            20                  25                  30          


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
        35                  40                  45              


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
    50                  55                  60                  


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
65                  70                  75                  80  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
                85                  90                  95      


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
            100                 105                 110         


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
        115                 120                 125             


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
    130                 135                 140                 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
                165                 170                 175     


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
            180                 185                 190         


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
        195                 200                 205             


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
    210                 215                 220                 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
                245                 250                 255     


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
        275                 280                 285             


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
305                 310                 315                 320 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
                325                 330                 335     


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
            340                 345                 350         


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
        355                 360                 365             


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
    370                 375                 380                 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
385                 390                 395                 400 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
                405                 410                 415     


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
            420                 425                 430         


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
    450                 455                 460                 


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
465                 470                 475                 480 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 
        515                 520                 525             


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
545                 550                 555                 560 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
                565                 570                 575     


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
            580                 585                 590         


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        595                 600                 605             


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Leu Arg Glu Leu His Leu Asn Asn Asn Cys 
1               5                   10  


<210>  45
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile 
    


<210>  46
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Cys Ser Gly Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp 
1               5                   10                  15      


Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
            20                  25                  30          


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
        35                  40                  45              


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
    50                  55                  60                  


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
65                  70                  75                  80  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
                85                  90                  95      


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
            100                 105                 110         


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
        115                 120                 125             


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
    130                 135                 140                 


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
145                 150                 155                 160 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
                165                 170                 175     


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
            180                 185                 190         


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly 
        195                 200                 205 


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  48
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Leu Ser Gly Arg Ser Asp Asn His 
1               5               


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Val Pro Leu Ser Leu Tyr Ser 
1               5           


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Val Leu Val Pro Met Ala Met Met Ala Ser 
1               5                   10  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<400>  53

Xaa Xaa Gln Ala Arg Ala Xaa 
1               5           


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Ala Gly Pro Arg 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Ala Ala Asn Leu 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Pro Thr Asn Leu 
1               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  57

Thr Ser Gly Arg Ser Ala Asn Pro 
1               5               


<210>  58
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln Leu 
1               5                   10                  15      


Gln Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg Lys 
            20                  25                  30          


Lys Val Glu Lys Leu Ser Glu 
        35                  


<210>  59
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  59

Gly Ala Ser Thr Thr Val Ala Gln Leu Arg Glu Arg Val Lys Thr Leu 
1               5                   10                  15      


Arg Ala Gln Asn Tyr Glu Leu Glu Ser Glu Val Gln Arg Leu Arg Glu 
            20                  25                  30          


Gln Val Ala Gln Leu Ala 
        35              


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Glu Ala Cys Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val 
1               5                   10                  15      


Asp Gln Leu Gln Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln 
            20                  25                  30          


Leu Arg Lys Lys Val Glu Lys Leu Ser Glu 
        35                  40          


<210>  61
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  61

Glu Ala Cys Gly Ala Ser Thr Thr Val Ala Gln Leu Arg Glu Arg Val 
1               5                   10                  15      


Lys Thr Leu Arg Ala Gln Asn Tyr Glu Leu Glu Ser Glu Val Gln Arg 
            20                  25                  30          


Leu Arg Glu Gln Val Ala Gln Leu Ala 
        35                  40      


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Ala Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr 
        35                  40  


<210>  63
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40  


<210>  64
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Glu Ala Cys Gly Ala Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu 
1               5                   10                  15      


Asn Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln 
            20                  25                  30          


Arg Ala Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr 
        35                  40                  45  


<210>  65
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Glu Ala Cys Gly Ala Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg 
1               5                   10                  15      


Asn Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln 
            20                  25                  30          


Arg Leu Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40                  45  


<210>  66
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Leu Glu Ile Arg Ala Ala Phe Leu Arg Arg Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Ile 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40  


<210>  67
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Leu Glu Ile Glu Ala Ala Phe Leu Glu Gln Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Ile 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40  


<210>  68
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Glu Ala Cys Gly Ala Leu Glu Ile Arg Ala Ala Phe Leu Arg Arg Arg 
1               5                   10                  15      


Asn Thr Ala Leu Arg Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln 
            20                  25                  30          


Arg Leu Arg Asn Ile Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40                  45  


<210>  69
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  69

Glu Ala Cys Gly Ala Leu Glu Ile Glu Ala Ala Phe Leu Glu Gln Glu 
1               5                   10                  15      


Asn Thr Ala Leu Glu Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln 
            20                  25                  30          


Arg Leu Glu Asn Ile Val Ser Gln Tyr Glu Thr Arg Tyr 
        35                  40                  45  


<210>  70
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  70

Gln Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln 
1               5                   10                  15      


Leu Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg 
            20                  25                  30          


Lys Lys Val Glu Lys Leu 
        35              


<210>  71
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  71

Gln Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val Lys Thr 
1               5                   10                  15      


Leu Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg Leu Glu 
            20                  25                  30          


Glu Gln Val Ala Gln Leu 
        35              


<210>  72
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  72

Glu Ala Cys Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val 
1               5                   10                  15      


Asp Gln Leu Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln 
            20                  25                  30          


Leu Arg Lys Lys Val Glu Lys Leu 
        35                  40  


<210>  73
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  73

Glu Ala Cys Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val 
1               5                   10                  15      


Lys Thr Leu Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg 
            20                  25                  30          


Leu Glu Glu Gln Val Ala Gln Leu 
        35                  40  


<210>  74
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  74

Ala Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp 
1               5                   10                  15      


Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys 
            20                  25                  30          


Glu Lys Leu Glu Phe Ile Leu Ala Ala His 
        35                  40          


<210>  75
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  75

Ala Gly Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala 
1               5                   10                  15      


Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val 
            20                  25                  30          


Ala Gln Leu Lys Gln Lys Val Met Asn Tyr 
        35                  40          


<210>  76
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  76

Glu Ala Cys Gly Ala Gly Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp 
1               5                   10                  15      


Gln Leu Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu 
            20                  25                  30          


Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His 
        35                  40                  45      


<210>  77
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  77

Glu Ala Cys Gly Ala Gly Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
1               5                   10                  15      


Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
            20                  25                  30          


Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn Tyr 
        35                  40                  45      


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  78

Gly Lys Ile Ala Ala Leu Lys Gln Lys Ile Ala Ala Leu Lys Tyr Lys 
1               5                   10                  15      


Asn Ala Ala Leu Lys Lys Lys Ile Ala Ala Leu Lys Gln 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  79

Gly Glu Ile Ala Ala Leu Glu Gln Glu Ile Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Asn Ala Ala Leu Glu Trp Glu Ile Ala Ala Leu Glu Gln 
            20                  25                  


<210>  80
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  80

Glu Ala Cys Gly Ala Gly Lys Ile Ala Ala Leu Lys Gln Lys Ile Ala 
1               5                   10                  15      


Ala Leu Lys Tyr Lys Asn Ala Ala Leu Lys Lys Lys Ile Ala Ala Leu 
            20                  25                  30          


Lys Gln 
        


<210>  81
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  81

Glu Ala Cys Gly Ala Gly Glu Ile Ala Ala Leu Glu Gln Glu Ile Ala 
1               5                   10                  15      


Ala Leu Glu Lys Glu Asn Ala Ala Leu Glu Trp Glu Ile Ala Ala Leu 
            20                  25                  30          


Glu Gln 
        


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  82

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  83
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  83

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  84

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  85

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  86

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  87

His His His His His His 
1               5       


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  88

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  89
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  89

Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  90

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  91
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  91

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  92
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  92

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  93

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  94

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  95

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  96
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  96

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  97

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  98

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  99

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  100

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  101

Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  102
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  102

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  103
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  103

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His 
        35                  40      


<210>  104
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  104

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro Leu 
1               5                   10                  15      


Gly Val Arg Gly Lys 
            20      


<210>  105
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  105

Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro 
1               5                   10                  15      


Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala 
            20                  25                  30          


Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu 
        35                  40          


<210>  106
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  106

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro Leu 
1               5                   10                  15      


Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala 
            20                  25                  30          


Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro 
        35                  40                  45              


Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu 
    50                  55                  60              


<210>  107
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  107

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys 
1               5                   10                  


<210>  108
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  108

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly Lys 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln 
    50                  55                  60                  


Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly 
65                  70                  75                  80  


Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly 
                85                  90                  95      


Leu 
    


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  109

Tyr Leu Gly Arg Ser Tyr Lys Val 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  110

Thr Ser Gln Val Asn Gly Leu Asn 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  111

Ala Pro Pro Pro Val Val Leu Leu 
1               5               


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  112

Gly Gly Gly Gly Phe 
1               5   


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  113

Thr Pro Glu His Val Val Pro Tyr 
1               5               


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  114

Pro Arg Ser Phe Phe Arg Leu Gly Lys 
1               5                   


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  115

Pro Gln Gly Arg Ile Val Gly Gly 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  116

Glu Val Leu Leu Ser Trp Ala Val 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  117

Pro Val Ser Leu Ser Tyr Arg Cys 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  118

Leu Arg Glu Leu His Leu Asp Asn 
1               5               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  119

Ala Ala Pro Val 
1               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  120

Ile Pro Glu Asn Phe Phe Gly Val 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  121

Pro Arg Phe Lys Ile Ile Gly Gly 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  122

Met Leu Glu Asp Glu Ala Ser Gly 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  123

Lys Gln Ser Arg Lys Phe Val Pro 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  124

Arg Gln Ala Arg Val Val Gly Gly 
1               5               


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  125

Gly Lys Ala Phe Arg Arg Leu 
1               5           


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  126

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  127

Ser Leu Gly Arg Lys Ile Gln Ile 
1               5               


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  128

Pro Val Ser Leu Arg 
1               5   


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  129

Ala Ala Ala Thr Ser Ile Ala Met 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  130

Ala Ala Gly Ala Met Phe Leu Glu 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  131

Glu Ala Ala Ala Ala Thr Ser Ile 
1               5               


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  132

Pro Arg His Leu Arg 
1               5   


<210>  133
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  133

Pro Arg Gly Leu Arg Lys 
1               5       


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  134

Val Pro Leu Ser Leu Tyr Ser Gly 
1               5               


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  135

Pro Arg Gly Leu Arg Pro 
1               5       


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  136

Pro Arg His Leu Arg Asn 
1               5       


<210>  137
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  137

Pro Arg Trp Leu Arg Ser 
1               5       


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  138

His Pro Val Gly Leu Leu Ala Arg 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  139

Lys Gly Pro Leu Gly Val Arg Gly 
1               5               


<210>  140
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  140

Cys Gly Leu Asp Asp 
1               5   


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  141

Ser Thr Ala Val Ile Val Ser Ala 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  142

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  143
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  143

Pro Leu Gly Leu Trp Ala 
1               5       


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  144

Gly Pro Leu Gly Met Leu Ser Gln 
1               5               


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  145

Pro Leu Gly Val Arg Gly Lys 
1               5           


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  146

Gly Pro Gln Gly Ile Trp Gly Gln 
1               5               


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  147

Ala Ile Pro Val Ser Leu Arg 
1               5           


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  148

Gly Pro Leu Gly Leu Ala Arg Lys 
1               5               


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  149

Pro Gln Gly Ile Ala Met Gly 
1               5           


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  150

Val Ala Ser Ser Ser Thr Ala Val 
1               5               


<210>  151
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  151

Pro Leu Gly Leu 
1               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  152

Arg Pro Leu Ala Leu Trp Arg Ser 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  153

Asn Lys Ser Arg Leu Gly Leu Gly 
1               5               


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  154

Gly Pro Gln Gly Ile Ala Gly Gln Arg 
1               5                   


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  155

Pro Val Gly Leu Ile Gly 
1               5       


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  156

Lys Pro Val Ser Leu Ser Tyr Arg 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  157

Gln Pro Val Gly Ile Asn Thr Ser 
1               5               


<210>  158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  158

Pro Leu Gly Met Thr Ser 
1               5       


<210>  159
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  159

Pro Arg Ala Leu Met 
1               5   


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  160

Gly Pro Leu Pro Leu Arg 
1               5       


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  161

Lys Gln Leu Arg Val Val Asn Gly 
1               5               


<210>  162
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  162

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  163

His Ser Ser Lys Leu Gln Leu 
1               5           


<210>  164
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  164

Ser Ser Lys Tyr Gln 
1               5   


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  165

Gly Pro Leu Gly Val Arg Gly Lys 
1               5               


<210>  166
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  166

Pro Arg Gly Met Ala Ser 
1               5       


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  167

Ala Ala Ala Leu Gly Asn Val Ala Pro 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  168

Gly Gly Ser Gly Arg Ser Ala Asn Ala 
1               5                   


<210>  169
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  169

Pro Leu Gly Val Arg Gly 
1               5       


<210>  170
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  170

Ser Gly Arg Ser Ala Asn Ala Lys 
1               5               


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  171

Gly Pro Leu Gly Leu Trp Ala Gly Gly 
1               5                   


<210>  172
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  172

Ser Gly Arg Ser Ala 
1               5   


<210>  173
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  173

Pro Leu Gly Leu Tyr Leu 
1               5       


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  174

Ser Arg Arg Arg Val Asn Ser Leu 
1               5               


<210>  175
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  175

Gly Ser Thr Phe Phe 
1               5   


<210>  176
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  176

Cys Pro Gly Arg Val Val Gly Gly 
1               5               


<210>  177
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  177

Gly Thr Gln Phe Phe 
1               5   


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  178

Pro Gln Gly Leu Ala Gly 
1               5       


<210>  179
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  179

Gln Val Val Ala Gly 
1               5   


<210>  180
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  180

Thr Tyr Ser Arg Ser Arg Tyr Leu 
1               5               


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  181

Asn Ser Gly Arg Ala Val Thr Tyr 
1               5               


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  182

Gly Pro Gln Gly Ala Arg Gly Gln 
1               5               


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  183

Pro Ser Ser Arg Arg Arg Val Asn 
1               5               


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  184

Pro Leu Gly Leu Tyr Ala Leu 
1               5           


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  185

Pro Met Lys Arg Leu Thr Leu Gly 
1               5               


<210>  186
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  186

Asp Asp Asp Lys Ile Val Gly Gly 
1               5               


<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  187

His Leu Val Glu Ala Leu Tyr Leu 
1               5               


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  188

Glu Val Asp Leu Leu Ile Gly Ser 
1               5               


<210>  189
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  189

Ala Val Arg Trp Leu Leu Thr Ala 
1               5               


<210>  190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  190

Gly Gly Gly Arg Arg 
1               5   


<210>  191
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  191

Gly Gly Gly Ser 
1               


<210>  192
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  192

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala 
    


<210>  193
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  193

His His His His His 
1               5   


<210>  194
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  194

Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro 
1               5                   10                  15      


Gly Thr Pro Gly Leu 
            20      


<210>  195
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  195

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu 
    210     


<210>  196
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  196

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                245                 250                 255     


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
            260                 265                 270         


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
        275                 280                 285             


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
    290                 295                 300                 


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
305                 310                 315                 320 


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
                325                 330                 335     


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
            340                 345                 350         


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
        355                 360                 365             


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
    370                 375                 380                 


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
385                 390                 395                 400 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
                405                 410                 415     


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
            420                 425                 430         


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
        435                 440                 445             


Tyr Leu Asn Ala Ser 
    450             


<210>  197
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  197

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu 
    210                 215                 220                 


Tyr Ser Gly His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu 
225                 230                 235                 240 


Tyr Ser Gly Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            260                 265                 270         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        275                 280                 285             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    290                 295                 300                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
305                 310                 315                 320 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                325                 330                 335     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            340                 345                 350         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        355                 360                 365             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    370                 375                 380                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
385                 390                 395                 400 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                405                 410                 415     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            420                 425                 430         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        435                 440                 445             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    450                 455                 


<210>  198
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  198

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
                245                 250                 255     


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
            260                 265                 270         


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln 
    290                 295                 300                 


Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg 
305                 310                 315                 320 


Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu 
                325                 330                 335     


Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu 
            340                 345                 350         


Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser 
        355                 360                 365             


Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met 
    370                 375                 380                 


Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr 
385                 390                 395                 400 


Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln 
                405                 410                 415     


Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln 
            420                 425                 430         


Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly 
        435                 440                 445             


Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His 
    450                 455                 460                 


Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu 
465                 470                 475                 480 


Ser Ser Ala 
            


<210>  199
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  199

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro 
                245                 250                 255     


Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly Ser Arg Val 
            260                 265                 270         


Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu 
        275                 280                 285             


Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys 
    290                 295                 300                 


His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg 
305                 310                 315                 320 


Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys 
                325                 330                 335     


Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly 
            340                 345                 350         


Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu 
        355                 360                 365             


Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala 
    370                 375                 380                 


Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp 
385                 390                 395                 400 


Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His 
                405                 410                 415     


Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro 
            420                 425                 430         


Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr 
        435                 440                 445             


Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    450                 455                 460             


<210>  200
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  200

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe 
                245                 250                 255     


Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly 
            260                 265                 270         


Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser 
    290                 295                 300                 


Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala 
305                 310                 315                 320 


Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His 
                325                 330                 335     


Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro 
            340                 345                 350         


Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser 
        355                 360                 365             


Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met 
    370                 375                 380                 


Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
385                 390                 395                 400 


Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln 
                405                 410                 415     


Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met 
            420                 425                 430         


Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val 
        435                 440                 445             


Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu 
    450                 455                 460                 


His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr 
465                 470                 475                 480 


Leu Ser Ser Ala 
                


<210>  201
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  201

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro 
                245                 250                 255     


Leu Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly 
            260                 265                 270         


Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro 
        275                 280                 285             


Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
305                 310                 315                 320 


Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
                325                 330                 335     


Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
            340                 345                 350         


Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
        355                 360                 365             


Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
    370                 375                 380                 


Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
385                 390                 395                 400 


Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
                405                 410                 415     


Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
            420                 425                 430         


Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
        435                 440                 445             


Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
    450                 455                 460                 


Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
465                 470                 475                 480 


Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
                485                 490                 495     


Arg Val Met Gly Tyr Leu Ser Ser Ala 
            500                 505 


<210>  202
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  202

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
                245                 250                 255     


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
            260                 265                 270         


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly 
        275                 280                 285             


Lys Pro Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    290                 295                 300                 


Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 
305                 310                 315                 320 


Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 
                325                 330                 335     


Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 
            340                 345                 350         


Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 
        355                 360                 365             


His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 
    370                 375                 380                 


Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 
385                 390                 395                 400 


Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 
                405                 410                 415     


Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 
            420                 425                 430         


Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 
        435                 440                 445             


Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 
    450                 455                 460                 


Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 
465                 470                 475                 480 


Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 
                485                 490                 495     


Ala 
    


<210>  203
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  203

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
                245                 250                 255     


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
            260                 265                 270         


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly 
        275                 280                 285             


Lys Pro Leu Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro 
    290                 295                 300                 


Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg 
305                 310                 315                 320 


Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro 
                325                 330                 335     


Gly Leu Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser 
            340                 345                 350         


Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 
        355                 360                 365             


Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 
    370                 375                 380                 


Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 
385                 390                 395                 400 


Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 
            420                 425                 430         


Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 
    450                 455                 460                 


Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 
465                 470                 475                 480 


Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 
                485                 490                 495     


Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 
            500                 505                 510         


Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 
        515                 520                 525             


Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    530                 535                 


<210>  204
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  204

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Cys Cys Val Glu Lys Thr Ser 
        195                 200                 205             


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
    210                 215                 220                 


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
225                 230                 235                 240 


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
                245                 250                 255     


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
        275                 280                 285             


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
    290                 295                 300                 


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
                325                 330                 335     


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
            340                 345                 350         


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
        355                 360                 365             


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
    370                 375                 380                 


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
385                 390                 395                 400 


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
                405                 410                 415     


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
            420                 425                 430         


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
        435                 440                 445             


Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser 
465                 470                 475                 480 


Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala 
                485                 490                 495     


Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His 
            500                 505                 510         


Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro 
        515                 520                 525             


Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser 
    530                 535                 540                 


Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met 
545                 550                 555                 560 


Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
                565                 570                 575     


Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln 
            580                 585                 590         


Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met 
        595                 600                 605             


Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val 
    610                 615                 620                 


Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu 
625                 630                 635                 640 


His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr 
                645                 650                 655     


Leu Ser Ser Ala 
            660 


<210>  205
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  205

Cys Ser Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser 
1               5                   10                  15      


Phe Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 
            20                  25                  30          


Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu 
        35                  40                  45              


Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro 
    50                  55                  60                  


Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly 
65                  70                  75                  80  


Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu 
                85                  90                  95      


Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val 
            100                 105                 110         


Ile Leu Val Thr Asp Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp 
        115                 120                 125             


Ala Ala Arg Ser Asn Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp 
    130                 135                 140                 


Arg Tyr Asp Ala Ala Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp 
145                 150                 155                 160 


Ser Asn Val Val Lys Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val 
                165                 170                 175     


Thr Leu Gly Asn Ser Phe Leu His Lys Leu Cys Ser Gly Phe Val Arg 
            180                 185                 190         


Ile Gly Gly Gly Ser Gly Gly Gly Ser Cys Cys Val Glu Lys Thr Ser 
        195                 200                 205             


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
    210                 215                 220                 


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
225                 230                 235                 240 


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
                245                 250                 255     


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
        275                 280                 285             


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
    290                 295                 300                 


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
                325                 330                 335     


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
            340                 345                 350         


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
        355                 360                 365             


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
    370                 375                 380                 


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
385                 390                 395                 400 


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
                405                 410                 415     


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
            420                 425                 430         


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
        435                 440                 445             


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
    450                 455                 460                 


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln 
                485                 490                 495     


Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg 
            500                 505                 510         


Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu 
        515                 520                 525             


Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu 
    530                 535                 540                 


Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser 
545                 550                 555                 560 


Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met 
                565                 570                 575     


Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr 
            580                 585                 590         


Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln 
        595                 600                 605             


Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln 
    610                 615                 620                 


Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly 
625                 630                 635                 640 


Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His 
                645                 650                 655     


Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu 
            660                 665                 670         


Ser Ser Ala 
        675 


<210>  206
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  206

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly 
                245                 250                 255     


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
            260                 265                 270         


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu 
        275                 280                 285             


Ser Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu Ser Gly Arg 
    290                 295                 300                 


Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro 
305                 310                 315                 320 


Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys 
                325                 330                 335     


Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr 
            340                 345                 350         


Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln 
        355                 360                 365             


Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu 
    370                 375                 380                 


Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys 
385                 390                 395                 400 


Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser 
                405                 410                 415     


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn 
            420                 425                 430         


Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly 
        435                 440                 445             


Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly 
    450                 455                 460                 


Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg 
465                 470                 475                 480 


Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val 
                485                 490                 495     


Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
            500                 505                 


<210>  207
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  207

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Pro Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser 
    290                 295                 300                 


Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu 
305                 310                 315                 320 


Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp 
                325                 330                 335     


Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu 
            340                 345                 350         


Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr 
        355                 360                 365             


Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr 
    370                 375                 380                 


Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu 
385                 390                 395                 400 


Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile 
                405                 410                 415     


Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser 
            420                 425                 430         


Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu 
        435                 440                 445             


Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala 
    450                 455                 460                 


Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser 
465                 470                 475                 480 


Ser Ala 
        


<210>  208
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  208

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser His Pro Val Gly Leu Leu 
                245                 250                 255     


Ala Arg His Pro Val Gly Leu Leu Ala Arg His Pro Val Gly Leu Leu 
            260                 265                 270         


Ala Arg Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser 
        275                 280                 285             


Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 
    290                 295                 300                 


Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 
305                 310                 315                 320 


Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 
                325                 330                 335     


Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 
            340                 345                 350         


Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 
        355                 360                 365             


Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 
    370                 375                 380                 


Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 
385                 390                 395                 400 


Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 
                405                 410                 415     


Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 
            420                 425                 430         


Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 
        435                 440                 445             


Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 
    450                 455                 460                 


Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
465                 470                 475 


<210>  209
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  209

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Leu Leu Ser Gly 
                245                 250                 255     


Arg Ser Asp Asn His Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
            260                 265                 270         


Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser 
    290                 295                 300                 


Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala 
305                 310                 315                 320 


Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His 
                325                 330                 335     


Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro 
            340                 345                 350         


Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser 
        355                 360                 365             


Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met 
    370                 375                 380                 


Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
385                 390                 395                 400 


Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln 
                405                 410                 415     


Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met 
            420                 425                 430         


Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val 
        435                 440                 445             


Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu 
    450                 455                 460                 


His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr 
465                 470                 475                 480 


Leu Ser Ser Ala 
                


<210>  210
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  210

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser His Pro Val Gly Leu Leu 
                245                 250                 255     


Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly Ser Gly Leu Leu Ser Gly 
            260                 265                 270         


Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
        275                 280                 285             


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
    290                 295                 300                 


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
305                 310                 315                 320 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
                325                 330                 335     


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
            340                 345                 350         


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
        355                 360                 365             


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
    370                 375                 380                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
385                 390                 395                 400 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
                405                 410                 415     


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
            420                 425                 430         


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
        435                 440                 445             


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
    450                 455                 460                 


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
465                 470                 475             


<210>  211
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  211

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr 
                245                 250                 255     


Ser Gly His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr 
            260                 265                 270         


Ser Gly Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys 
    290                 295                 300                 


Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys 
305                 310                 315                 320 


Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile 
                325                 330                 335     


Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys 
            340                 345                 350         


Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu 
        355                 360                 365             


Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser 
    370                 375                 380                 


Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met 
385                 390                 395                 400 


Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn 
                405                 410                 415     


His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu 
            420                 425                 430         


Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro 
        435                 440                 445             


Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile 
    450                 455                 460                 


Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met 
465                 470                 475                 480 


Gly Tyr Leu Ser Ser Ala 
                485     


<210>  212
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  212

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr 
                245                 250                 255     


Ser Gly Val Pro Leu Ser Leu Tyr Ser Gly Val Pro Leu Ser Leu Tyr 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val 
        275                 280                 285             


Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu 
    290                 295                 300                 


Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys 
305                 310                 315                 320 


His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg 
                325                 330                 335     


Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys 
            340                 345                 350         


Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly 
        355                 360                 365             


Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu 
    370                 375                 380                 


Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala 
385                 390                 395                 400 


Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp 
                405                 410                 415     


Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His 
            420                 425                 430         


Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro 
        435                 440                 445             


Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr 
    450                 455                 460                 


Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
465                 470                 475                 


<210>  213
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  213

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp 
            260                 265                 270         


Asn His Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln 
    290                 295                 300                 


Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg 
305                 310                 315                 320 


Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu 
                325                 330                 335     


Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu 
            340                 345                 350         


Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser 
        355                 360                 365             


Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met 
    370                 375                 380                 


Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr 
385                 390                 395                 400 


Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln 
                405                 410                 415     


Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln 
            420                 425                 430         


Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly 
        435                 440                 445             


Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His 
    450                 455                 460                 


Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu 
465                 470                 475                 480 


Ser Ser Ala 
            


<210>  214
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  214

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu 
    210                 215                 220                 


Tyr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser 
225                 230                 235                 240 


Asp Asn His Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Gly Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
            260                 265                 270         


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
        275                 280                 285             


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
    290                 295                 300                 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
305                 310                 315                 320 


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
                325                 330                 335     


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
            340                 345                 350         


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
        355                 360                 365             


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
    370                 375                 380                 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
385                 390                 395                 400 


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
                405                 410                 415     


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
            420                 425                 430         


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
        435                 440                 445             


Arg Val Met Ser Tyr Leu Asn Ala Ser 
    450                 455         


<210>  215
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  215

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu 
    210                 215                 220                 


Tyr Ser Gly Val Pro Leu Ser Leu Tyr Ser Gly Val Pro Leu Ser Leu 
225                 230                 235                 240 


Tyr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg 
                245                 250                 255     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            260                 265                 270         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        275                 280                 285             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    290                 295                 300                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
305                 310                 315                 320 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                325                 330                 335     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            340                 345                 350         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        355                 360                 365             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    370                 375                 380                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
385                 390                 395                 400 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                405                 410                 415     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            420                 425                 430         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        435                 440                 445             


Leu Asn Ala Ser 
    450         


<210>  216
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  216

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Gly Gly Gly Ser Gly Gly Gly Ser His Pro Val Gly Leu 
    210                 215                 220                 


Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly Ser Gly Leu Leu Ser 
225                 230                 235                 240 


Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser Arg Asn 
                245                 250                 255     


Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His 
            260                 265                 270         


Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg 
        275                 280                 285             


Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu 
    290                 295                 300                 


Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu 
305                 310                 315                 320 


Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe 
                325                 330                 335     


Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met 
            340                 345                 350         


Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val 
        355                 360                 365             


Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln 
    370                 375                 380                 


Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln 
385                 390                 395                 400 


Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu 
                405                 410                 415     


Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His 
            420                 425                 430         


Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu 
        435                 440                 445             


Asn Ala Ser 
    450     


<210>  217
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  217

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly 
    210                 215                 220                 


Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe 
225                 230                 235                 240 


Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly 
                245                 250                 255     


Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
        275                 280                 285             


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
    290                 295                 300                 


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
305                 310                 315                 320 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
                325                 330                 335     


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
            340                 345                 350         


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
        355                 360                 365             


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
    370                 375                 380                 


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
385                 390                 395                 400 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
                405                 410                 415     


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
            420                 425                 430         


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
        435                 440                 445             


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
    450                 455                 460                 


Val Met Ser Tyr Leu Asn Ala Ser 
465                 470         


<210>  218
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  218

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr 
    210                 215                 220                 


Ser Gly His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser 
225                 230                 235                 240 


Gly Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val 
                245                 250                 255     


Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
        275                 280                 285             


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
    290                 295                 300                 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
305                 310                 315                 320 


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
                325                 330                 335     


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
            340                 345                 350         


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
        355                 360                 365             


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
    370                 375                 380                 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
385                 390                 395                 400 


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
                405                 410                 415     


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
            420                 425                 430         


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
        435                 440                 445             


Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
    450                 455                 460                 


Met Ser Tyr Leu Asn Ala Ser 
465                 470     


<210>  219
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  219

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly 
            20                  25                  30          


Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
        35                  40              


<210>  220
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  220

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly 
            20                  25                  30          


Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


<210>  221
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  221

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
1               5                   10                  15      


Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
            20                  25      


<210>  222
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  222

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu Ser 
        35                  40                  45              


Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser 
    50                  55                  60                  


Asp Asn His 
65          


<210>  223
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  223

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Pro Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45          


<210>  224
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  224

His Pro Val Gly Leu Leu Ala Arg His Pro Val Gly Leu Leu Ala Arg 
1               5                   10                  15      


His Pro Val Gly Leu Leu Ala Arg 
            20                  


<210>  225
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  225

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser 
    


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  226

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro Leu 
1               5                   10                  15      


Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  


<210>  227
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  227

Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro 
1               5                   10                  15      


Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala 
            20                  25                  30          


Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  228
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  228

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Pro Leu 
1               5                   10                  15      


Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala 
            20                  25                  30          


Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly Pro Pro 
        35                  40                  45              


Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Ser 
65                  70      


<210>  229
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  229

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser 
            20          


<210>  230
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  230

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly Lys 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Lys Gly Glu Arg Gly Pro Pro Gly Pro Gln 
    50                  55                  60                  


Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Gly Glu Arg Gly 
65                  70                  75                  80  


Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr Pro Gly 
                85                  90                  95      


Leu Gly Gly Gly Ser Gly Gly Gly Ser 
            100                 105 


<210>  231
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  231

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser 
1               5                   10                  15      


Gly Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser 
        


<210>  232
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  232

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu Ser 
        35                  40                  45              


Gly Arg Ser Asp Asn His Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser 
    50                  55                  60                  


Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser 
65                  70                  75  


<210>  233
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  233

Gly Gly Gly Ser Gly Gly Gly Ser His Pro Val Gly Leu Leu Ala Arg 
1               5                   10                  15      


His Pro Val Gly Leu Leu Ala Arg His Pro Val Gly Leu Leu Ala Arg 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


<210>  234
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  234

Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Ser Gly Leu Leu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Asn His Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn 
            20                  25                  30          


His 
    


<210>  235
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  235

Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Leu Leu Ser Gly Arg Ser 
1               5                   10                  15      


Asp Asn His Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser 
    


<210>  236
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  236

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
            20                  25          


<210>  237
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  237

Gly Gly Gly Ser Gly Gly Gly Ser His Pro Val Gly Leu Leu Ala Arg 
1               5                   10                  15      


Val Pro Leu Ser Leu Tyr Ser Gly Ser Gly Leu Leu Ser Gly Arg Ser 
            20                  25                  30          


Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40              


<210>  238
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  238

Val Pro Leu Ser Leu Tyr Ser Gly Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


Val Pro Leu Ser Leu Tyr Ser 
            20              


<210>  239
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  239

Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


Val Pro Leu Ser Leu Tyr Ser Gly Val Pro Leu Ser Leu Tyr Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  


<210>  240
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  240

Val Pro Leu Ser Leu Tyr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Leu Ser Gly Arg Ser Asp Asn His Leu Ser Gly Arg Ser Asp Asn His 
            20                  25                  30          


<210>  241
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  241

Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His 
            20                  25                  30          


Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


<210>  242
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  242

Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Leu Ser Leu Tyr Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His 
            20                  25                  30          


Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly 
    


<210>  243
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  243

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Gly Glu 
1               5                   10                  15      


Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr 
            20                  25                  30          


Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg 
        35                  40                  45              


Gly Phe Pro Gly Thr Pro Gly Leu 
    50                  55      


<210>  244
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  244

Pro Leu Gly Val Arg Gly Lys Pro Leu Gly Val Arg Gly Lys Gly Glu 
1               5                   10                  15      


Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg Gly Phe Pro Gly Thr 
            20                  25                  30          


Pro Gly Leu Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Ala Arg 
        35                  40                  45              


Gly Phe Pro Gly Thr Pro Gly Leu Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


<210>  245
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  245

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly Lys 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Lys 
    50                  55  


<210>  246
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  246

His Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly His 
1               5                   10                  15      


Pro Val Gly Leu Leu Ala Arg Val Pro Leu Ser Tyr Ser Gly Ser Gly 
            20                  25                  30          


Leu Leu Ser Gly Arg Ser Asp Asn His Pro Leu Gly Val Arg Gly Lys 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60              


<210>  247
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  247

Gln Leu Gly Ala Ser Gly Pro Gly Asp Cys Cys Val Glu Lys Thr Ser 
1               5                   10                  15      


Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu Ser 
            20                  25                  30          


Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr Asp 
        35                  40                  45              


Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val Pro 
    50                  55                  60                  


Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser Ser 
65                  70                  75                  80  


Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro Val 
                85                  90                  95      


Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg Thr 
            100                 105                 110         


Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys Thr 
        115                 120                 125             


Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln Leu 
    130                 135                 140                 


Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln Phe 
145                 150                 155                 160 


Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly Pro 
                165                 170                 175     


Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser Met 
            180                 185                 190         


Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile Gln 
        195                 200                 205             


Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro Trp 
    210                 215                 220                 


Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro Gln 
225                 230                 235                 240 


Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Arg Val Ile 
        275                 280                 285             


Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu 
    290                 295                 300                 


Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 
305                 310                 315                 320 


Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 
                325                 330                 335     


Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn 
            340                 345                 350         


Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser 
        355                 360                 365             


Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly 
    370                 375                 380                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile 
385                 390                 395                 400 


Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys 
                405                 410                 415     


Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn 
            420                 425                 430         


Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr 
        435                 440                 445             


Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg 
    450                 455                 460                 


Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala His His 
465                 470                 475                 480 


His His His His 
                


<210>  248
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  248

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                245                 250                 255     


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
            260                 265                 270         


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
        275                 280                 285             


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
    290                 295                 300                 


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
305                 310                 315                 320 


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
                325                 330                 335     


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
            340                 345                 350         


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
        355                 360                 365             


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
    370                 375                 380                 


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
385                 390                 395                 400 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
                405                 410                 415     


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
            420                 425                 430         


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
        435                 440                 445             


Tyr Leu Asn Ala Ser His His His His His His 
    450                 455                 


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X is alanine, arginine, asparagine, aspartic acid, cysteine, 
       glutamine, glutamic acid, glycine, histidine, isoleucine, 
       leucine, lysine, methionine, phenylalanine, proline, serine, 
       threonine, tryptophan, tyrosine, or valine

<400>  249

Xaa Xaa Gln Ala Arg Val Xaa 
1               5           


