﻿                         序列表

<110>  江苏创健医疗科技有限公司

<120>  一种重组人XVII型胶原蛋白、制备方法和应用

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1497
<212>  PRT
<213>  人(Homo sapiens)

<400>  1
Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu 
1               5                   10                  15      
Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro 
            20                  25                  30          
Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly 
        35                  40                  45              
Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr 
    50                  55                  60                  
Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr 
65                  70                  75                  80  
Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser 
                85                  90                  95      
Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser 
            100                 105                 110         
Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser 
        115                 120                 125             
Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val 
    130                 135                 140                 
Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp 
145                 150                 155                 160 
Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr 
                165                 170                 175     
Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu 
            180                 185                 190         
Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp 
        195                 200                 205             
Ala Thr Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr 
    210                 215                 220                 
Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr 
225                 230                 235                 240 
Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val 
                245                 250                 255     
Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro 
            260                 265                 270         
Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala 
        275                 280                 285             
Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala 
    290                 295                 300                 
Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr 
305                 310                 315                 320 
Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp 
                325                 330                 335     
Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr 
            340                 345                 350         
Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly 
        355                 360                 365             
Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser 
    370                 375                 380                 
Glu Asp Thr Leu Lys Lys Glu Lys Gln Ala Ala Tyr Asn Ala Asp Ser 
385                 390                 395                 400 
Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys 
                405                 410                 415     
Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Gly Ser Ser Gly Gly 
            420                 425                 430         
Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro 
        435                 440                 445             
Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp 
    450                 455                 460                 
Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly 
465                 470                 475                 480 
Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys 
                485                 490                 495     
Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr 
            500                 505                 510         
Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala 
        515                 520                 525             
Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser 
    530                 535                 540                 
Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln 
545                 550                 555                 560 
Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly 
                565                 570                 575     
Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile 
            580                 585                 590         
Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys 
        595                 600                 605             
Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly 
    610                 615                 620                 
Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser 
625                 630                 635                 640 
Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly 
                645                 650                 655     
Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser 
            660                 665                 670         
Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg 
        675                 680                 685             
Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly 
    690                 695                 700                 
Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu 
705                 710                 715                 720 
Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro 
                725                 730                 735     
Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly 
            740                 745                 750         
Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro 
        755                 760                 765             
Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln 
    770                 775                 780                 
Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly 
785                 790                 795                 800 
Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met 
                805                 810                 815     
Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro 
            820                 825                 830         
Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly 
        835                 840                 845             
His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 
Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly 
865                 870                 875                 880 
Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe 
                885                 890                 895     
Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         
Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
        915                 920                 925             
Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser 
    930                 935                 940                 
Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly 
945                 950                 955                 960 
Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile 
                965                 970                 975     
Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser 
            980                 985                 990         
Gly Pro Pro Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Ser Ile Ser 
        995                 1000                 1005             
Ser Ser  Gly Gln Glu Ile Gln  Gln Tyr Ile Ser Glu  Tyr Met Gln Ser 
    1010                 1015                 1020                 
Asp  Ser Ile Arg Ser Tyr  Leu Ser Gly Val Gln  Gly Pro Pro Gly Pro  
1025                 1030                 1035                 1040 
Pro Gly Pro Pro Gly  Pro Val Thr Thr Ile  Thr Gly Glu Thr Phe  Asp 
                1045                 1050                 1055     
Tyr Ser Glu Leu  Ala Ser His Val Val  Ser Tyr Leu Arg Thr  Ser Gly 
            1060                 1065                 1070         
Tyr Gly Val  Ser Leu Phe Ser Ser  Ser Ile Ser Ser Glu  Asp Ile Leu 
        1075                 1080                 1085             
Ala Val  Leu Gln Arg Asp Asp  Val Arg Gln Tyr Leu  Arg Gln Tyr Leu 
    1090                 1095                 1100                 
Met  Gly Pro Arg Gly Pro  Pro Gly Pro Pro Gly  Ala Ser Gly Asp Gly  
1105                 1110                 1115                 1120 
Ser Leu Leu Ser Leu  Asp Tyr Ala Glu Leu  Ser Ser Arg Ile Leu  Ser 
                1125                 1130                 1135     
Tyr Met Ser Ser  Ser Gly Ile Ser Ile  Gly Leu Pro Gly Pro  Pro Gly 
            1140                 1145                 1150         
Pro Pro Gly  Leu Pro Gly Thr Ser  Tyr Glu Glu Leu Leu  Ser Leu Leu 
        1155                 1160                 1165             
Arg Gly  Ser Glu Phe Arg Gly  Ile Val Gly Pro Pro  Gly Pro Pro Gly 
    1170                 1175                 1180                 
Pro  Pro Gly Ile Pro Gly  Asn Val Trp Ser Ser  Ile Ser Val Glu Asp  
1185                 1190                 1195                 1200 
Leu Ser Ser Tyr Leu  His Thr Ala Gly Leu  Ser Phe Ile Pro Gly  Pro 
                1205                 1210                 1215     
Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro Pro Gly  Val Ser 
            1220                 1225                 1230         
Gly Ala Leu  Ala Thr Tyr Ala Ala  Glu Asn Ser Asp Ser  Phe Arg Ser 
        1235                 1240                 1245             
Glu Leu  Ile Ser Tyr Leu Thr  Ser Pro Asp Val Arg  Ser Phe Ile Val 
    1250                 1255                 1260                 
Gly  Pro Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Asp Ser Arg  
1265                 1270                 1275                 1280 
Leu Leu Ser Thr Asp  Ala Ser His Ser Arg  Gly Ser Ser Ser Ser  Ser 
                1285                 1290                 1295     
His Ser Ser Ser  Val Arg Arg Gly Ser  Ser Tyr Ser Ser Ser  Met Ser 
            1300                 1305                 1310         
Thr Gly Gly  Gly Gly Ala Gly Ser  Leu Gly Ala Gly Gly  Ala Phe Gly 
        1315                 1320                 1325             
Glu Ala  Ala Gly Asp Arg Gly  Pro Tyr Gly Thr Asp  Ile Gly Pro Gly 
    1330                 1335                 1340                 
Gly  Gly Tyr Gly Ala Ala  Ala Glu Gly Gly Met  Tyr Ala Gly Asn Gly  
1345                 1350                 1355                 1360 
Gly Leu Leu Gly Ala  Asp Phe Ala Gly Asp  Leu Asp Tyr Asn Glu  Leu 
                1365                 1370                 1375     
Ala Val Arg Val  Ser Glu Ser Met Gln  Arg Gln Gly Leu Leu  Gln Gly 
            1380                 1385                 1390         
Met Ala Tyr  Thr Val Gln Gly Pro  Pro Gly Gln Pro Gly  Pro Gln Gly 
        1395                 1400                 1405             
Pro Pro  Gly Ile Ser Lys Val  Phe Ser Ala Tyr Ser  Asn Val Thr Ala 
    1410                 1415                 1420                 
Asp  Leu Met Asp Phe Phe  Gln Thr Tyr Gly Ala  Ile Gln Gly Pro Pro  
1425                 1430                 1435                 1440 
Gly Gln Lys Gly Glu  Met Gly Thr Pro Gly  Pro Lys Gly Asp Arg  Gly 
                1445                 1450                 1455     
Pro Ala Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Pro Arg  Gly His 
            1460                 1465                 1470         
Lys Gly Glu  Lys Gly Asp Lys Gly  Asp Gln Val Tyr Ala  Gly Arg Arg 
        1475                 1480                 1485             
Arg Arg  Arg Ser Ile Ala Val  Lys Pro 
    1490                 1495         

<210>  2
<211>  233
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gly Ser Pro Gly Pro Lys Gly Asp Met Gly Ser Pro Gly Pro Lys Gly 
1               5                   10                  15      
Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile Pro Gly Pro Leu Gly His 
            20                  25                  30          
Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys Gly Ser Val Gly Asp Pro 
        35                  40                  45              
Gly Met Glu Gly Pro Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu 
    50                  55                  60                  
Pro Gly Pro His Gly Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys 
65                  70                  75                  80  
Gly Ser Ser Gly Ser Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly 
                85                  90                  95      
Leu Gln Gly Leu Arg Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp 
            100                 105                 110         
Lys Gly Pro Met Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys 
        115                 120                 125             
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly 
    130                 135                 140                 
Pro Pro Gly Pro Arg Gly His Gln Gly Glu Gln Gly Leu Pro Gly Phe 
145                 150                 155                 160 
Ser Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Lys Gly Asp Lys 
                165                 170                 175     
Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile Pro Gly Pro Pro Gly 
            180                 185                 190         
Gln Lys Gly Glu Met Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Pro 
        195                 200                 205             
Ala Gly Pro Pro Gly His Pro Gly Pro Pro Gly Pro Arg Gly His Lys 
    210                 215                 220                 
Gly Glu Lys Gly Asp Lys Gly Asp Gln 
225                 230             

<210>  3
<211>  466
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Gly Ser Pro Gly Pro Lys Gly Asp Met Gly Ser Pro Gly Pro Lys Gly 
1               5                   10                  15      
Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile Pro Gly Pro Leu Gly His 
            20                  25                  30          
Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys Gly Ser Val Gly Asp Pro 
        35                  40                  45              
Gly Met Glu Gly Pro Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu 
    50                  55                  60                  
Pro Gly Pro His Gly Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys 
65                  70                  75                  80  
Gly Ser Ser Gly Ser Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly 
                85                  90                  95      
Leu Gln Gly Leu Arg Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp 
            100                 105                 110         
Lys Gly Pro Met Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys 
        115                 120                 125             
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly 
    130                 135                 140                 
Pro Pro Gly Pro Arg Gly His Gln Gly Glu Gln Gly Leu Pro Gly Phe 
145                 150                 155                 160 
Ser Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Lys Gly Asp Lys 
                165                 170                 175     
Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile Pro Gly Pro Pro Gly 
            180                 185                 190         
Gln Lys Gly Glu Met Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Pro 
        195                 200                 205             
Ala Gly Pro Pro Gly His Pro Gly Pro Pro Gly Pro Arg Gly His Lys 
    210                 215                 220                 
Gly Glu Lys Gly Asp Lys Gly Asp Gln Gly Ser Pro Gly Pro Lys Gly 
225                 230                 235                 240 
Asp Met Gly Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr 
                245                 250                 255     
Pro Gly Ile Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys 
            260                 265                 270         
Gly Gln Lys Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Gly Glu 
        275                 280                 285             
Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly Pro Pro 
    290                 295                 300                 
Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser Pro Gly 
305                 310                 315                 320 
Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg Gly Glu 
                325                 330                 335     
Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly Pro Pro 
            340                 345                 350         
Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Pro Gly Pro Pro Gly 
        355                 360                 365             
Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
    370                 375                 380                 
Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Pro Pro 
385                 390                 395                 400 
Gly Pro Gln Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly 
                405                 410                 415     
Ala Leu Gly Ile Pro Gly Pro Pro Gly Gln Lys Gly Glu Met Gly Thr 
            420                 425                 430         
Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Pro Pro Gly His Pro 
        435                 440                 445             
Gly Pro Pro Gly Pro Arg Gly His Lys Gly Glu Lys Gly Asp Lys Gly 
    450                 455                 460                 
Asp Gln 
465     

<210>  4
<211>  249
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Tyr Val Trp Ser His Pro Gln Phe Glu Lys Gly Ser Pro Gly Pro Lys 
1               5                   10                  15      
Gly Asp Met Gly Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly 
            20                  25                  30          
Thr Pro Gly Ile Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro 
        35                  40                  45              
Lys Gly Gln Lys Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Gly 
    50                  55                  60                  
Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly Pro 
65                  70                  75                  80  
Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser Pro 
                85                  90                  95      
Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg Gly 
            100                 105                 110         
Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly Pro 
        115                 120                 125             
Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 
Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly 
145                 150                 155                 160 
His Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Pro 
                165                 170                 175     
Pro Gly Pro Gln Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro 
            180                 185                 190         
Gly Ala Leu Gly Ile Pro Gly Pro Pro Gly Gln Lys Gly Glu Met Gly 
        195                 200                 205             
Thr Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Pro Pro Gly His 
    210                 215                 220                 
Pro Gly Pro Pro Gly Pro Arg Gly His Lys Gly Glu Lys Gly Asp Lys 
225                 230                 235                 240 
Gly Asp Gln His His His His His His 
                245                 

<210>  5
<211>  482
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Tyr Val Trp Ser His Pro Gln Phe Glu Lys Gly Ser Pro Gly Pro Lys 
1               5                   10                  15      
Gly Asp Met Gly Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly 
            20                  25                  30          
Thr Pro Gly Ile Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro 
        35                  40                  45              
Lys Gly Gln Lys Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Gly 
    50                  55                  60                  
Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly Pro 
65                  70                  75                  80  
Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser Pro 
                85                  90                  95      
Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg Gly 
            100                 105                 110         
Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly Pro 
        115                 120                 125             
Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 
Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly 
145                 150                 155                 160 
His Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Pro 
                165                 170                 175     
Pro Gly Pro Gln Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro 
            180                 185                 190         
Gly Ala Leu Gly Ile Pro Gly Pro Pro Gly Gln Lys Gly Glu Met Gly 
        195                 200                 205             
Thr Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Pro Pro Gly His 
    210                 215                 220                 
Pro Gly Pro Pro Gly Pro Arg Gly His Lys Gly Glu Lys Gly Asp Lys 
225                 230                 235                 240 
Gly Asp Gln Gly Ser Pro Gly Pro Lys Gly Asp Met Gly Ser Pro Gly 
                245                 250                 255     
Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile Pro Gly Pro 
            260                 265                 270         
Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys Gly Ser Val 
        275                 280                 285             
Gly Asp Pro Gly Met Glu Gly Pro Gly Glu Lys Gly Glu Arg Gly Ala 
    290                 295                 300                 
Ala Gly Glu Pro Gly Pro His Gly Pro Pro Gly Val Pro Gly Ser Val 
305                 310                 315                 320 
Gly Pro Lys Gly Ser Ser Gly Ser Pro Gly Pro Gln Gly Pro Pro Gly 
                325                 330                 335     
Pro Val Gly Leu Gln Gly Leu Arg Gly Glu Val Gly Leu Pro Gly Val 
            340                 345                 350         
Lys Gly Asp Lys Gly Pro Met Gly Pro Pro Gly Pro Lys Gly Asp Gln 
        355                 360                 365             
Gly Glu Lys Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Lys Gly 
    370                 375                 380                 
Asp Gln Gly Pro Pro Gly Pro Arg Gly His Gln Gly Glu Gln Gly Leu 
385                 390                 395                 400 
Pro Gly Phe Ser Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Lys 
                405                 410                 415     
Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile Pro Gly 
            420                 425                 430         
Pro Pro Gly Gln Lys Gly Glu Met Gly Thr Pro Gly Pro Lys Gly Asp 
        435                 440                 445             
Arg Gly Pro Ala Gly Pro Pro Gly His Pro Gly Pro Pro Gly Pro Arg 
    450                 455                 460                 
Gly His Lys Gly Glu Lys Gly Asp Lys Gly Asp Gln His His His His 
465                 470                 475                 480 
His His 
        

<210>  6
<211>  699
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  6
ggttctcctg gtccaaaagg tgacatgggt tctccaggtc ctaaaggtga cagaggtttt        60
cctggtactc caggtattcc tggtccattg ggtcatccag gtcctcaagg tccaaaaggt       120
caaaagggtt ctgttggtga ccctggtatg gaaggtccag gtgaaaaggg tgaaagaggt       180
gctgctggtg aacctggtcc acacggtcca cctggtgttc caggttctgt tggtcctaag       240
ggttcttctg gttctcctgg tccacaaggt cctcctggtc cagttggttt gcaaggtttg       300
agaggtgaag ttggtttgcc aggtgttaag ggtgacaagg gtccaatggg tcctccaggt       360
ccaaaaggtg accaaggtga aaagggtcca cctggtcctc ctggtccacc tggtccaaag       420
ggtgaccaag gtcctccagg tcctagaggt catcaaggtg aacaaggttt gcctggtttt       480
tctggtccac caggtcctcc aggtccacaa ggtcctaaag gtgacaaagg tgacccaggt       540
gttcctggtg ctttgggtat tccaggtcca cctggtcaaa aaggtgaaat gggtactcca       600
ggtcctaagg gtgacagagg tccagctggt ccacctggtc atcctggtcc accaggtcca       660
agaggtcata agggtgaaaa aggtgacaag ggtgaccaa                              699

<210>  7
<211>  1398
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
ggttctccag gtcctaaagg tgacatgggt tctccaggtc ctaagggtga cagaggtttt        60
ccaggtactc caggtattcc aggtcctttg ggtcatccag gtcctcaagg tcctaaaggt       120
caaaaaggtt ctgttggtga ccctggtatg gaaggtcctg gtgaaaaagg tgaaagaggt       180
gctgctggtg aacctggtcc acacggtcct ccaggtgttc ctggttctgt tggtccaaaa       240
ggttcttctg gttctcctgg tccacaaggt cctccaggtc ctgttggttt gcaaggtttg       300
agaggtgaag ttggtttgcc aggtgttaaa ggtgacaaag gtccaatggg tcctccaggt       360
ccaaagggtg accaaggtga aaaaggtcca cctggtcctc ctggtccacc aggtccaaaa       420
ggtgaccaag gtccacctgg tccaagaggt caccaaggtg aacaaggttt gcctggtttt       480
tctggtcctc caggtcctcc tggtcctcaa ggtccaaagg gtgacaaggg tgaccctggt       540
gttccaggtg ctttgggtat tcctggtcct ccaggtcaaa agggtgagat gggtactcct       600
ggtcctaagg gtgacagagg tccagctggt cctcctggtc acccaggtcc tcctggtcct       660
agaggtcata aaggtgaaaa aggtgacaag ggtgaccaag gttctccagg tccaaagggt       720
gacatgggtt ctcctggtcc aaaaggtgac agaggtttcc ctggtactcc aggtattcct       780
ggtccattgg gtcacccagg tccacaaggt ccaaaaggtc aaaaaggttc tgttggtgac       840
ccaggtatgg aaggtccagg tgaaaagggt gaaagaggtg ctgctggtga accaggtcct       900
catggtccac caggtgttcc aggttctgtt ggtccaaagg gttcttctgg ttctccaggt       960
ccacaaggtc ctccaggtcc agttggtttg caaggtttga gaggtgaagt tggtttgcct      1020
ggtgttaagg gtgacaaagg tcctatgggt cctcctggtc ctaaaggtga ccaaggtgaa      1080
aagggtccac caggtcctcc aggtccacct ggtccaaaag gtgaccaagg tccaccaggt      1140
cctagaggtc atcaaggtga acaaggtttg ccaggttttt ctggtccacc aggtccacca      1200
ggtcctcaag gtcctaaggg tgacaaaggt gacccaggtg ttcctggtgc tttgggtatt      1260
cctggtccac ctggtcaaaa gggtgaaatg ggtactcctg gtcctaaagg tgacagaggt      1320
cctgctggtc cacctggtca tccaggtcca cctggtccaa gaggtcacaa aggtgaaaag      1380
ggtgacaagg gtgaccaa                                                    1398

<210>  8
<211>  758
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
tacgtatggt ctcatccaca attcgagaag ggttctcctg gtccaaaagg tgacatgggt        60
tctccaggtc ctaaaggtga cagaggtttt cctggtactc caggtattcc tggtccattg       120
ggtcatccag gtcctcaagg tccaaaaggt caaaagggtt ctgttggtga ccctggtatg       180
gaaggtccag gtgaaaaggg tgaaagaggt gctgctggtg aacctggtcc acacggtcca       240
cctggtgttc caggttctgt tggtcctaag ggttcttctg gttctcctgg tccacaaggt       300
cctcctggtc cagttggttt gcaaggtttg agaggtgaag ttggtttgcc aggtgttaag       360
ggtgacaagg gtccaatggg tcctccaggt ccaaaaggtg accaaggtga aaagggtcca       420
cctggtcctc ctggtccacc tggtccaaag ggtgaccaag gtcctccagg tcctagaggt       480
catcaaggtg aacaaggttt gcctggtttt tctggtccac caggtcctcc aggtccacaa       540
ggtcctaaag gtgacaaagg tgacccaggt gttcctggtg ctttgggtat tccaggtcca       600
cctggtcaaa aaggtgaaat gggtactcca ggtcctaagg gtgacagagg tccagctggt       660
ccacctggtc atcctggtcc accaggtcca agaggtcata agggtgaaaa aggtgacaag       720
ggtgaccaac accatcatca ccatcattaa gcggccgc                               758

<210>  9
<211>  1457
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
tacgtatggt ctcatcctca atttgaaaag ggttctccag gtcctaaagg tgacatgggt        60
tctccaggtc ctaagggtga cagaggtttt ccaggtactc caggtattcc aggtcctttg       120
ggtcatccag gtcctcaagg tcctaaaggt caaaaaggtt ctgttggtga ccctggtatg       180
gaaggtcctg gtgaaaaagg tgaaagaggt gctgctggtg aacctggtcc acacggtcct       240
ccaggtgttc ctggttctgt tggtccaaaa ggttcttctg gttctcctgg tccacaaggt       300
cctccaggtc ctgttggttt gcaaggtttg agaggtgaag ttggtttgcc aggtgttaaa       360
ggtgacaaag gtccaatggg tcctccaggt ccaaagggtg accaaggtga aaaaggtcca       420
cctggtcctc ctggtccacc aggtccaaaa ggtgaccaag gtccacctgg tccaagaggt       480
caccaaggtg aacaaggttt gcctggtttt tctggtcctc caggtcctcc tggtcctcaa       540
ggtccaaagg gtgacaaggg tgaccctggt gttccaggtg ctttgggtat tcctggtcct       600
ccaggtcaaa agggtgagat gggtactcct ggtcctaagg gtgacagagg tccagctggt       660
cctcctggtc acccaggtcc tcctggtcct agaggtcata aaggtgaaaa aggtgacaag       720
ggtgaccaag gttctccagg tccaaagggt gacatgggtt ctcctggtcc aaaaggtgac       780
agaggtttcc ctggtactcc aggtattcct ggtccattgg gtcacccagg tccacaaggt       840
ccaaaaggtc aaaaaggttc tgttggtgac ccaggtatgg aaggtccagg tgaaaagggt       900
gaaagaggtg ctgctggtga accaggtcct catggtccac caggtgttcc aggttctgtt       960
ggtccaaagg gttcttctgg ttctccaggt ccacaaggtc ctccaggtcc agttggtttg      1020
caaggtttga gaggtgaagt tggtttgcct ggtgttaagg gtgacaaagg tcctatgggt      1080
cctcctggtc ctaaaggtga ccaaggtgaa aagggtccac caggtcctcc aggtccacct      1140
ggtccaaaag gtgaccaagg tccaccaggt cctagaggtc atcaaggtga acaaggtttg      1200
ccaggttttt ctggtccacc aggtccacca ggtcctcaag gtcctaaggg tgacaaaggt      1260
gacccaggtg ttcctggtgc tttgggtatt cctggtccac ctggtcaaaa gggtgaaatg      1320
ggtactcctg gtcctaaagg tgacagaggt cctgctggtc cacctggtca tccaggtcca      1380
cctggtccaa gaggtcacaa aggtgaaaag ggtgacaagg gtgaccaaca ccatcaccat      1440
catcattaag cggccgc                                                     1457

<210>  10
<211>  4550
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
gaattctgga gtcatcctca attcgaaaaa atggatgtca ctaaaaagaa caagagagac        60
ggaactgagg tcactgagag aatcgttacc gaaactgtca ccacaagact tacttcatta       120
cctccaaagg gtggaacttc taatggttac gcaaagacag catcattagg aggtggttca       180
agacttgaga aacaatccct tactcatggt tcaagtggat acataaattc aactggttca       240
acaagaggac atgcaagtac ttcttcttat agaagagcac atagtccagc atcaactttg       300
cccaactctc ctggttcaac atttgagaga aaaactcatg taaccagaca tgcctatgag       360
ggttctagtt ctggtaattc atctccagaa taccctagaa aagagtttgc atcatcctca       420
actagaggta gatcacagac tagagaatct gaaatcagag tcagattaca atcagcatct       480
ccttcaacta gatggactga gttagacgac gtgaaaagat tattaaaggg atcaagaagt       540
gcaagtgttt cccctacaag aaattcttcc aacacccttc ccattcctaa gaaaggaacc       600
gttgaaacta aaatcgttac agcatcatct cagtctgtat ccggaaccta cgacgctacc       660
attctggacg ccaacttacc ttctcatgtc tggtcttcaa ctttacccgc aggttcctca       720
atgggaactt accacaataa catgactact caatcaagtt ctcttctgaa taccaatgca       780
tactcagccg gttccgtttt tggagtccct aacaatatgg cctcttgctc cccaactctt       840
catccaggtc tttcaacctc atcaagtgta tttggtatgc agaacaactt agccccttcc       900
ttgacaaccc tgtctcatgg tactactacc actagtacag catatggagt caagaagaac       960
atgccacagt cacctgctgc cgttaacact ggagtttcaa catctgctgc ctgcactaca      1020
tctgttcaat cagatgatct tctgcataag gactgcaagt ttttaatttt agagaaagac      1080
aatacccctg ccaaaaagga aatggagtta cttataatga ccaaagattc tggtaaagta      1140
ttcactgctt ctcccgctag tatcgccgca acttcattct ctgaagatac tttaaagaag      1200
gaaaaacaag ccgcatacaa cgcagactca ggtttaaaag cagaagcaaa cggtgacctt      1260
aaaacagtgt caactaaggg aaagactaca accgcagaca tccattcata tggttcttca      1320
ggtggaggag gatctggagg aggtggtgga gtgggaggtg ctggaggagg tccatggggt      1380
cctgcacctg catggtgccc ttgcggttct tgctgcagtt ggtggaagtg gcttctgggt      1440
ttattattaa cttggctgct tttactgggt cttttattcg gtcttatcgc attagcagaa      1500
gaggtcagaa aacttaaggc cagagttgat gagttagaga gaatcagaag atcaatcctt      1560
ccctatggag actccatgga cagaatcgaa aaggatagac ttcagggtat ggcccctgca      1620
gcaggagctg atctggataa aatcggactt cattcagatt ctcaagagga attatggatg      1680
tttgttagaa agaaacttat gatggagcag gagaacggta acctgagagg ttctcctggt      1740
ccaaaaggag atatgggttc acccggtccc aaaggagata gaggattccc tggtactcca      1800
ggtatccccg gtcccctggg tcaccctgga cctcaaggtc ctaaaggtca aaagggttct      1860
gtaggagatc caggtatgga gggtcccatg ggtcagagag gtagagaagg tcccatggga      1920
ccaagaggtg aagctggacc tcccggaagt ggtgaaaaag gagaaagagg agcagcagga      1980
gaacctggac cccatggacc tccaggagtt cctggatcag tcggacccaa aggttcatcc      2040
ggttctcctg gacctcaagg tccaccagga cccgtcggat tgcaaggatt gagaggagaa      2100
gttggacttc ccggagttaa gggtgacaag ggtcctatgg gtcctcctgg tccaaaggga      2160
gatcagggtg aaaagggtcc tagaggtctg actggtgaac caggaatgag aggacttccc      2220
ggtgccgtgg gtgaacccgg tgcaaaagga gcaatgggtc ctgccggtcc tgatggacac      2280
cagggaccca gaggagagca gggattaaca ggaatgcctg gtatcagagg tcccccaggt      2340
ccctcaggag acccaggaaa gccaggactt actggtcccc agggtcctca aggtctgcct      2400
ggaactcccg gaagacccgg aatcaaaggt gaaccaggag ccccaggaaa aatcgttact      2460
agtgaaggat cttcaatgct gactgtgcca ggtccacctg gtcctcctgg agctatgggt      2520
cctcccggtc cccctggagc acccggtcct gcaggtcctg ccggattacc tggacatcag      2580
gaagtcttaa acctgcaagg tccaccaggt cctcctggtc caagaggacc ccctggtcct      2640
tcaatccctg gtccacctgg acctagaggt ccacccggag agggacttcc cggaccacca      2700
ggacctcctg gatcatttct gtctaattct gagacatttc tttcaggacc tcctggtcct      2760
cccggaccac ctggaccaaa aggagatcag ggaccacctg gtcccagagg acatcaagga      2820
gagcagggtc ttccaggttt ctctacttct ggatcatcat catttggtct taatcttcaa      2880
ggtcctcctg gacccccagg accacaggga cccaagggtg acaagggaga ccctggagtc      2940
ccaggtgcac tgggaatccc ttcaggtcct tcagaaggtg gttcatcttc aaccatgtat      3000
gtgtctggac ccccaggacc tcccggacct ccaggtcctc ctggttcaat ctcttcttct      3060
ggtcaagaaa ttcagcagta tatttctgag tacatgcaat ctgactctat tagaagttat      3120
ttgtctggtg tgcagggtcc accaggtcct ccaggtcccc ctggaccagt cactactatc      3180
actggagaga catttgatta tagtgaatta gcatcacacg tcgtttctta tctgagaact      3240
tcaggttatg gtgtttcatt attttcctcc tcaatctctt cagaagacat cttagccgta      3300
ctgcagagag atgatgtaag acagtacctt agacaatact tgatgggtcc aagaggacca      3360
ccaggtccac ccggtgcatc aggagacgga tcattattat ctttggatta cgctgaatta      3420
tcatcaagaa tccttagtta catgtcctct tctggtatct ccataggtct gcccggtcct      3480
cctggtcctc ccggacttcc tggtacttct tacgaagagc ttctgtcact tttaagagga      3540
tctgagttta gaggtatagt tggtccccca ggacctccag gtcctccagg tatcccaggt      3600
aacgtgtggt catctatctc agttgaggat ctttcatctt atcttcacac cgccggattg      3660
tcctttatac ctggtcctcc aggaccccct ggacctcctg gacccagagg tcctccagga      3720
gtatccggtg ctttagcaac ttatgcagca gaaaactccg attcttttag atcagaattg      3780
atctcctacc ttacttctcc tgatgttaga tcattcatcg tcggacctcc aggaccacct      3840
ggacctcaag gacctcctgg agattcaaga ttactgagta cagatgcatc acattcaaga      3900
ggttcaagtt cttcttctca ctcctcttct gttagaagag gatcatcata ttcatcaagt      3960
atgtcaactg gtggaggagg agctggttca ttgggtgccg gaggtgcatt tggtgaggcc      4020
gctggtgaca gaggacctta tggtactgac attggacctg gtggaggtta tggtgcagca      4080
gcagaaggtg gaatgtatgc tggtaatgga ggtttactgg gagccgactt tgccggagac      4140
ctggactaca acgagttagc tgttagagtg tcagagtcaa tgcagagaca aggattatta      4200
cagggtatgg cttatacagt tcagggaccc ccaggtcagc caggtcctca aggaccccct      4260
ggtatttcaa aagtcttctc cgcttattct aacgttactg cagacctgat ggatttcttc      4320
cagacttacg gtgccatcca aggtcctcca ggacagaagg gtgaaatggg aactcccggt      4380
cccaagggtg acagaggtcc tgcaggacct cctggtcacc ctggaccacc tggacctaga      4440
ggacacaaag gtgagaaggg tgacaaggga gaccaggttt acgcaggaag aagaagaaga      4500
agaagtattg ccgtcaagcc tcaccatcac catcatcact aagcggccgc                 4550

