                         SEQUENCE LISTING

<110>  Nykode Therapeutics AS
 
<120>  Tolerance-inducing constructs and compositions and their use for 
       the treatment of immune disorders

<130>  P6011PC00

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Amino acid sequence of hinge exon h1 from IgG3

<220>
<221>  MISC_FEATURE
<222>  (13)..(27)
<223>  Amino acid sequence of and hinge exon h4 from IgG3

<400>  1

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser 
1               5                   10                  15      


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25          


<210>  2
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(23)
<223>  Amino acid sequence of hinge regions of IgG1

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro 
            20              


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Amino acid sequence of the CH3 domain of human IgG3

<400>  3

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Amino acid sequence of the CH3 domain of human IgG1

<400>  4

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(29)
<223>  Amino acid sequence of the CREB bZIP motif

<400>  5

Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys 
1               5                   10                  15      


Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr 
            20                  25                  


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Mouse immunoglobulin heavy chain signal sequence (Ig VH signal 
       seq)

<400>  6

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  7
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(246)
<223>  Mouse single chain variable fragment (scFv) anti-DEC205

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Lys Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Leu Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile Arg Asn Lys 
                165                 170                 175     


Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly Gly 
    210                 215                 220                 


Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly Gln Gly Val 
225                 230                 235                 240 


Met Val Thr Val Ser Ser 
                245     


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Hinge region form human IgG1

<400>  8

Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  9
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(160)
<223>  Murine IL-10

<400>  9

Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro 
1               5                   10                  15      


Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu 
        35                  40                  45              


Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu 
                85                  90                  95      


Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe 
        115                 120                 125             


Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
145                 150                 155                 160 


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  Mature murine TGFbeta1

<400>  10

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  11
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(126)
<223>  Mature murine CTLA-4

<400>  11

Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala Ser Ser His 
1               5                   10                  15      


Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His Asn Thr Asp 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln Met Thr Glu 
        35                  40                  45              


Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly Phe Leu Asp 
    50                  55                  60                  


Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  12
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  MOG(27-63)

<400>  12

Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser 
1               5                   10                  15      


Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp 
            20                  25                  30          


Ala Glu Gln Ala Pro 
        35          


<210>  13
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(37)
<223>  MOG(27-63) sequence obtained from Krienke et al. 2021. Patent 
       US2020061166A1

<400>  13

Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser 
1               5                   10                  15      


Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp 
            20                  25                  30          


Ala Glu Ala Gln Pro 
        35          


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  MOG(35-55)

<400>  14

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  15
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  Murine MARCO ligand SCGB3A2 signal sequence

<400>  15

Met Lys Leu Val Ser Ile Phe Leu Leu Val Thr Ile Gly Ile Cys Gly 
1               5                   10                  15      


Tyr Ser Ala Thr Ala 
            20      


<210>  16
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(70)
<223>  Murine MARCO ligand SCGB3A2

<400>  16

Leu Leu Ile Asn Arg Leu Pro Val Val Asp Lys Leu Pro Val Pro Leu 
1               5                   10                  15      


Asp Asp Ile Ile Pro Ser Phe Asp Pro Leu Lys Met Leu Leu Lys Thr 
            20                  25                  30          


Leu Gly Ile Ser Val Glu His Leu Val Thr Gly Leu Lys Lys Cys Val 
        35                  40                  45              


Asp Glu Leu Gly Pro Glu Ala Ser Glu Ala Val Lys Lys Leu Leu Glu 
    50                  55                  60                  


Ala Leu Ser His Leu Val 
65                  70  


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  Murine VISTA ligand VSIG-3 signal sequence

<400>  17

Met Thr Arg Arg Arg Ser Ala Pro Ala Ser Trp Leu Leu Val Ser Leu 
1               5                   10                  15      


Leu Gly Val Ala Thr Ser 
            20          


<210>  18
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(218)
<223>  Murine VISTA ligand VSIG-3 extracellular domain

<400>  18

Leu Glu Val Ser Glu Ser Pro Gly Ser Val Gln Val Ala Arg Gly Gln 
1               5                   10                  15      


Thr Ala Val Leu Pro Cys Ala Phe Ser Thr Ser Ala Ala Leu Leu Asn 
            20                  25                  30          


Leu Asn Val Ile Trp Met Val Ile Pro Leu Ser Asn Ala Asn Gln Pro 
        35                  40                  45              


Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met Phe Asp Gly Ala Leu 
    50                  55                  60                  


Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr Met Pro Ala Thr Asn 
65                  70                  75                  80  


Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser Asp Thr Gly Thr Tyr 
                85                  90                  95      


Gln Cys Leu Val Asn Asn Leu Pro Asp Arg Gly Gly Arg Asn Ile Gly 
            100                 105                 110         


Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser Ala Pro Gln Cys Gln 
        115                 120                 125             


Ile Gln Gly Ser Gln Asp Leu Gly Ser Asp Val Ile Leu Leu Cys Ser 
    130                 135                 140                 


Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu Trp Glu Lys Leu Asp 
145                 150                 155                 160 


Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln Asp Gln Val Gln Gly 
                165                 170                 175     


Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser Ser Gly Leu Tyr Gln 
            180                 185                 190         


Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr Cys Leu Leu Asp Leu 
        195                 200                 205             


Gln Val Ile Ser Pro Gln Pro Arg Ser Val 
    210                 215             


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Hinge h1 hIgG3

<400>  19

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(23)
<223>  Human CCL3L1 signal sequence

<400>  20

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser 
            20              


<210>  21
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(70)
<223>  Human CCL3L1

<400>  21

Ala Pro Leu Ala Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr 
1               5                   10                  15      


Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala Asp Tyr Phe Glu Thr Ser 
            20                  25                  30          


Ser Gln Cys Ser Lys Pro Ser Val Ile Phe Leu Thr Lys Arg Gly Arg 
        35                  40                  45              


Gln Val Cys Ala Asp Pro Ser Glu Glu Trp Val Gln Lys Tyr Val Ser 
    50                  55                  60                  


Asp Leu Glu Leu Ser Ala 
65                  70  


<210>  22
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(171)
<223>  Met e 1 (241-260), (210-230), (136-155), (76-95), (46-65), 
       (16-35)

<400>  22

Lys Glu Val Asp Arg Leu Glu Asp Glu Leu Val Asn Glu Lys Glu Lys 
1               5                   10                  15      


Tyr Lys Ser Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr 
            20                  25                  30          


Lys Glu Gln Ile Lys Thr Leu Thr Asn Lys Leu Lys Ala Ala Glu Ala 
        35                  40                  45              


Arg Ala Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Gln Leu 
    50                  55                  60                  


Lys Glu Ala Arg Phe Leu Ala Glu Glu Ala Asp Arg Lys Tyr Asp Glu 
65                  70                  75                  80  


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Leu Asn Arg 
                85                  90                  95      


Arg Ile Gln Leu Leu Glu Glu Asp Leu Glu Arg Ser Glu Glu Arg Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Leu Asp Gln Val Gln Glu 
        115                 120                 125             


Ser Leu Leu Lys Ala Asn Asn Gln Leu Val Glu Lys Asp Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Gln Gln Asn Lys Glu Ala Asn Asn 
145                 150                 155                 160 


Arg Ala Glu Lys Ser Glu Glu Glu Val His Asn 
                165                 170     


<210>  23
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(514)
<223>  Amino acid sequence of VB5050.

<400>  23

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
        355                 360                 365             


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
    370                 375                 380                 


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
385                 390                 395                 400 


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
                405                 410                 415     


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
            420                 425                 430         


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
        435                 440                 445             


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
    450                 455                 460                 


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
465                 470                 475                 480 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
                485                 490                 495     


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
            500                 505                 510         


Lys Ser 
        


<210>  24
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(514)
<223>  Amino acid sequence of VB5038

<400>  24

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Ala Gln Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
        355                 360                 365             


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
    370                 375                 380                 


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
385                 390                 395                 400 


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
                405                 410                 415     


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
            420                 425                 430         


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
        435                 440                 445             


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
    450                 455                 460                 


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
465                 470                 475                 480 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
                485                 490                 495     


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
            500                 505                 510         


Lys Ser 
        


<210>  25
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(526)
<223>  Amino acid sequence of VB5042

<400>  25

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ser Arg 
        355                 360                 365             


Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro Val Gly 
    370                 375                 380                 


Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln Val Lys 
385                 390                 395                 400 


Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp 
                405                 410                 415     


Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
            420                 425                 430         


Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala Glu Lys 
        435                 440                 445             


His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu Lys Leu 
    450                 455                 460                 


Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
465                 470                 475                 480 


Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe Asn Lys 
                485                 490                 495     


Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe 
            500                 505                 510         


Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
        515                 520                 525     


<210>  26
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(466)
<223>  Amino acid sequence of VB5066

<400>  26

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn 
        355                 360                 365             


Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp 
    370                 375                 380                 


Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly 
385                 390                 395                 400 


Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu 
                405                 410                 415     


Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ser Pro Cys Cys 
            420                 425                 430         


Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg 
        435                 440                 445             


Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys 
    450                 455                 460                 


Cys Ser 
465     


<210>  27
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(478)
<223>  Amino acid sequence of VB5043

<400>  27

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Leu 
        355                 360                 365             


Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys Val Arg 
    370                 375                 380                 


Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His 
385                 390                 395                 400 


Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys Pro Tyr 
                405                 410                 415     


Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu Tyr Asn 
            420                 425                 430         


Gln His Asn Pro Gly Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Ala 
        435                 440                 445             


Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val 
    450                 455                 460                 


Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
465                 470                 475             


<210>  28
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(480)
<223>  Amino acid sequence of VB5067

<400>  28

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn Ala Thr 
    290                 295                 300                 


Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His 
305                 310                 315                 320 


Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Gly Leu 
                325                 330                 335     


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            340                 345                 350         


Cys Pro Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala Ser 
        355                 360                 365             


Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His Asn 
    370                 375                 380                 


Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln Met 
385                 390                 395                 400 


Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly Phe 
                405                 410                 415     


Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val Asn 
            420                 425                 430         


Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu Cys 
        435                 440                 445             


Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly Asn 
    450                 455                 460                 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
465                 470                 475                 480 


<210>  29
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(340)
<223>  Amino acid sequence of VB5072

<400>  29

Met Lys Leu Val Ser Ile Phe Leu Leu Val Thr Ile Gly Ile Cys Gly 
1               5                   10                  15      


Tyr Ser Ala Thr Ala Leu Leu Ile Asn Arg Leu Pro Val Val Asp Lys 
            20                  25                  30          


Leu Pro Val Pro Leu Asp Asp Ile Ile Pro Ser Phe Asp Pro Leu Lys 
        35                  40                  45              


Met Leu Leu Lys Thr Leu Gly Ile Ser Val Glu His Leu Val Thr Gly 
    50                  55                  60                  


Leu Lys Lys Cys Val Asp Glu Leu Gly Pro Glu Ala Ser Glu Ala Val 
65                  70                  75                  80  


Lys Lys Leu Leu Glu Ala Leu Ser His Leu Val Glu Leu Lys Thr Pro 
                85                  90                  95      


Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            100                 105                 110         


Pro Cys Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn 
        115                 120                 125             


Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val 
    130                 135                 140                 


Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro 
145                 150                 155                 160 


Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                165                 170                 175     


Pro Pro Cys Pro Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys 
            180                 185                 190         


Thr His Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr 
        195                 200                 205             


Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp 
    210                 215                 220                 


Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu 
225                 230                 235                 240 


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val 
                245                 250                 255     


Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn 
            260                 265                 270         


Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys 
        275                 280                 285             


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val 
    290                 295                 300                 


Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met 
305                 310                 315                 320 


Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile 
                325                 330                 335     


Lys Met Lys Ser 
            340 


<210>  30
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(352)
<223>  Amino acid sequence of VB5073

<400>  30

Met Lys Leu Val Ser Ile Phe Leu Leu Val Thr Ile Gly Ile Cys Gly 
1               5                   10                  15      


Tyr Ser Ala Thr Ala Leu Leu Ile Asn Arg Leu Pro Val Val Asp Lys 
            20                  25                  30          


Leu Pro Val Pro Leu Asp Asp Ile Ile Pro Ser Phe Asp Pro Leu Lys 
        35                  40                  45              


Met Leu Leu Lys Thr Leu Gly Ile Ser Val Glu His Leu Val Thr Gly 
    50                  55                  60                  


Leu Lys Lys Cys Val Asp Glu Leu Gly Pro Glu Ala Ser Glu Ala Val 
65                  70                  75                  80  


Lys Lys Leu Leu Glu Ala Leu Ser His Leu Val Glu Leu Lys Thr Pro 
                85                  90                  95      


Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro 
            100                 105                 110         


Pro Cys Pro Arg Cys Pro Gly Leu Gly Gly Leu Ser Pro Gly Lys Asn 
        115                 120                 125             


Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val 
    130                 135                 140                 


Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro 
145                 150                 155                 160 


Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                165                 170                 175     


Pro Pro Cys Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
            180                 185                 190         


Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro 
        195                 200                 205             


Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln 
    210                 215                 220                 


Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu 
225                 230                 235                 240 


Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
                245                 250                 255     


Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala 
            260                 265                 270         


Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu 
        275                 280                 285             


Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu 
    290                 295                 300                 


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe 
305                 310                 315                 320 


Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp 
                325                 330                 335     


Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
            340                 345                 350         


<210>  31
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(489)
<223>  Amino acid sequence of VB5074

<400>  31

Met Thr Arg Arg Arg Ser Ala Pro Ala Ser Trp Leu Leu Val Ser Leu 
1               5                   10                  15      


Leu Gly Val Ala Thr Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Val 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Thr Ala Val Leu Pro Cys Ala Phe Ser Thr 
        35                  40                  45              


Ser Ala Ala Leu Leu Asn Leu Asn Val Ile Trp Met Val Ile Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Leu Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Arg 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro Gln Cys Gln Ile Gln Gly Ser Gln Asp Leu Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Ser Val 
225                 230                 235                 240 


Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Leu Gly Gly Leu 
            260                 265                 270         


Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser 
        275                 280                 285             


Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp 
    290                 295                 300                 


Ala Glu Gln Ala Pro Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp 
305                 310                 315                 320 


Lys Thr His Thr Cys Pro Pro Cys Pro Ser Arg Gly Gln Tyr Ser Arg 
                325                 330                 335     


Glu Asp Asn Asn Cys Thr His Phe Pro Val Gly Gln Ser His Met Leu 
            340                 345                 350         


Leu Glu Leu Arg Thr Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr 
        355                 360                 365             


Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp 
    370                 375                 380                 


Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe 
385                 390                 395                 400 


Tyr Leu Val Glu Val Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile 
                405                 410                 415     


Lys Glu His Leu Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met 
            420                 425                 430         


Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys 
        435                 440                 445             


Ala Val Glu Gln Val Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly 
    450                 455                 460                 


Val Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu 
465                 470                 475                 480 


Ala Tyr Met Met Ile Lys Met Lys Ser 
                485                 


<210>  32
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(501)
<223>  Amino acid sequence of VB5075

<400>  32

Met Thr Arg Arg Arg Ser Ala Pro Ala Ser Trp Leu Leu Val Ser Leu 
1               5                   10                  15      


Leu Gly Val Ala Thr Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Val 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Thr Ala Val Leu Pro Cys Ala Phe Ser Thr 
        35                  40                  45              


Ser Ala Ala Leu Leu Asn Leu Asn Val Ile Trp Met Val Ile Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Leu Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Arg 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro Gln Cys Gln Ile Gln Gly Ser Gln Asp Leu Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Ser Val 
225                 230                 235                 240 


Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Gly Leu Gly Gly Leu 
            260                 265                 270         


Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser 
        275                 280                 285             


Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp 
    290                 295                 300                 


Ala Glu Gln Ala Pro Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp 
305                 310                 315                 320 


Lys Thr His Thr Cys Pro Pro Cys Pro Glu Leu Lys Thr Pro Leu Gly 
                325                 330                 335     


Asp Thr Thr His Thr Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn 
            340                 345                 350         


Cys Thr His Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg 
        355                 360                 365             


Thr Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu 
    370                 375                 380                 


Asp Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr 
385                 390                 395                 400 


Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu 
                405                 410                 415     


Val Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu 
            420                 425                 430         


Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg 
        435                 440                 445             


Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln 
    450                 455                 460                 


Val Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala 
465                 470                 475                 480 


Met Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met 
                485                 490                 495     


Ile Lys Met Lys Ser 
            500     


<210>  33
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(279)
<223>  Amino acid sequence of VB5052

<400>  33

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr 
            100                 105                 110         


Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu Gly 
225                 230                 235                 240 


Gly Leu Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr 
                245                 250                 255     


Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp 
            260                 265                 270         


Gln Asp Ala Glu Gln Ala Pro 
        275                 


<210>  34
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(279)
<223>  Amino acid sequence of VB5002b

<400>  34

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala Glu Leu Lys 
                85                  90                  95      


Thr Pro Leu Gly Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr 
            100                 105                 110         


Pro Pro Pro Cys Pro Arg Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu Gly 
225                 230                 235                 240 


Gly Leu Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr 
                245                 250                 255     


Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp 
            260                 265                 270         


Gln Asp Ala Glu Gln Ala Pro 
        275                 


<210>  35
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(56)
<223>  Amino acid sequence of VB5051

<400>  35

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp 
            20                  25                  30          


Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys 
        35                  40                  45              


Asp Gln Asp Ala Glu Gln Ala Pro 
    50                  55      


<210>  36
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(56)
<223>  Amino acid sequence of VB5001b

<400>  36

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp 
            20                  25                  30          


Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys 
        35                  40                  45              


Asp Gln Asp Ala Glu Ala Gln Pro 
    50                  55      


<210>  37
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(648)
<223>  Amino acid sequence of VB5077

<400>  37

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Lys Glu Val Asp Arg Leu Glu 
    290                 295                 300                 


Asp Glu Leu Val Asn Glu Lys Glu Lys Tyr Lys Ser Ile Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Ala Tyr Lys Glu Gln Ile Lys Thr Leu 
                325                 330                 335     


Thr Asn Lys Leu Lys Ala Ala Glu Ala Arg Ala Glu Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Asn Gln Leu Lys Glu Ala Arg Phe Leu Ala 
        355                 360                 365             


Glu Glu Ala Asp Arg Lys Tyr Asp Glu Val Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu Glu 
385                 390                 395                 400 


Asp Leu Glu Arg Ser Glu Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Leu Asp Gln Val Gln Glu Ser Leu Leu Lys Ala Asn Asn 
            420                 425                 430         


Gln Leu Val Glu Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Glu Gln Gln Asn Lys Glu Ala Asn Asn Arg Ala Glu Lys Ser Glu Glu 
    450                 455                 460                 


Glu Val His Asn Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ser Arg Gly Gln Tyr Ser Arg Glu 
                485                 490                 495     


Asp Asn Asn Cys Thr His Phe Pro Val Gly Gln Ser His Met Leu Leu 
            500                 505                 510         


Glu Leu Arg Thr Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr Lys 
        515                 520                 525             


Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp Phe 
    530                 535                 540                 


Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr 
545                 550                 555                 560 


Leu Val Glu Val Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys 
                565                 570                 575     


Glu His Leu Asn Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met Arg 
            580                 585                 590         


Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala 
        595                 600                 605             


Val Glu Gln Val Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly Val 
    610                 615                 620                 


Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala 
625                 630                 635                 640 


Tyr Met Met Ile Lys Met Lys Ser 
                645             


<210>  38
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(660)
<223>  Amino acid sequence of VB5078

<400>  38

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Lys Glu Val Asp Arg Leu Glu 
    290                 295                 300                 


Asp Glu Leu Val Asn Glu Lys Glu Lys Tyr Lys Ser Ile Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Gly Gly Ser Ala Tyr Lys Glu Gln Ile Lys Thr Leu 
                325                 330                 335     


Thr Asn Lys Leu Lys Ala Ala Glu Ala Arg Ala Glu Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Asn Gln Leu Lys Glu Ala Arg Phe Leu Ala 
        355                 360                 365             


Glu Glu Ala Asp Arg Lys Tyr Asp Glu Val Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu Glu 
385                 390                 395                 400 


Asp Leu Glu Arg Ser Glu Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Leu Asp Gln Val Gln Glu Ser Leu Leu Lys Ala Asn Asn 
            420                 425                 430         


Gln Leu Val Glu Lys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Glu Gln Gln Asn Lys Glu Ala Asn Asn Arg Ala Glu Lys Ser Glu Glu 
    450                 455                 460                 


Glu Val His Asn Gly Leu Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Glu Leu Lys Thr Pro Leu Gly Asp 
                485                 490                 495     


Thr Thr His Thr Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys 
            500                 505                 510         


Thr His Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr 
        515                 520                 525             


Ala Phe Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp 
    530                 535                 540                 


Asn Ile Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu 
545                 550                 555                 560 


Gly Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val 
                565                 570                 575     


Met Pro Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn 
            580                 585                 590         


Ser Leu Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys 
        595                 600                 605             


His Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val 
    610                 615                 620                 


Lys Ser Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met 
625                 630                 635                 640 


Asn Glu Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile 
                645                 650                 655     


Lys Met Lys Ser 
            660 


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  39

Glu Ala Ala Lys Gly Ser 
1               5       


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  40

Gly Leu Ser Gly Leu 
1               5   


<210>  41
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(510)
<223>  Amino acid sequence of VB5041

<400>  41

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Thr 
            20                  25                  30          


Ser Leu Gly Asn Ser Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile 
        35                  40                  45              


Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Asn Ala Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe Thr Ile Ser Asn 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser 
            100                 105                 110         


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn 
                165                 170                 175     


Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile 
            180                 185                 190         


Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly 
                245                 250                 255     


Gln Gly Val Met Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly 
            260                 265                 270         


Asp Thr Thr His Thr Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        275                 280                 285             


Pro Arg Cys Pro Gly Leu Gly Gly Leu Met Glu Val Gly Trp Tyr Arg 
    290                 295                 300                 


Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Gly Leu 
305                 310                 315                 320 


Gln Gly Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                325                 330                 335     


Cys Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ser Arg 
            340                 345                 350         


Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro Val Gly 
        355                 360                 365             


Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln Val Lys 
    370                 375                 380                 


Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp 
385                 390                 395                 400 


Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
                405                 410                 415     


Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala Glu Lys 
            420                 425                 430         


His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu Lys Leu 
        435                 440                 445             


Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
    450                 455                 460                 


Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe Asn Lys 
465                 470                 475                 480 


Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe 
                485                 490                 495     


Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
            500                 505                 510 


<210>  42
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(36)
<223>  linker

<400>  42

Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val 
1               5                   10                  15      


Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser 
            20                  25                  30          


Leu Ser Arg Phe 
        35      


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  Natural leader sequence murine IL-10

<400>  43

Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile 
        


<210>  44
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(35)
<223>  Natural leader sequence murine CTLA4

<400>  44

Met Ala Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser 
        35  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(29)
<223>  Natural leader sequence murine transforming growth factor beta-1

<400>  45

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Pro 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly 
            20                  25                  


<210>  46
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(361)
<223>  Murine transforming growth factor beta-1 proprotein

<400>  46

Leu Ser Thr Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg 
1               5                   10                  15      


Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser 
            20                  25                  30          


Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val 
        35                  40                  45              


Leu Ala Leu Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala 
    50                  55                  60                  


Asp Pro Glu Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr 
65                  70                  75                  80  


Arg Val Leu Met Val Asp Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys 
                85                  90                  95      


Asp Ile Ser His Ser Ile Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg 
            100                 105                 110         


Glu Ala Val Pro Glu Pro Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu 
        115                 120                 125             


Gln Arg Leu Lys Ser Ser Val Glu Gln His Val Glu Leu Tyr Gln Lys 
    130                 135                 140                 


Tyr Ser Asn Asn Ser Trp Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro 
145                 150                 155                 160 


Thr Asp Thr Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg 
                165                 170                 175     


Gln Trp Leu Asn Gln Gly Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala 
            180                 185                 190         


His Cys Ser Cys Asp Ser Lys Asp Asn Lys Leu His Val Glu Ile Asn 
        195                 200                 205             


Gly Ile Ser Pro Lys Arg Arg Gly Asp Leu Gly Thr Ile His Asp Met 
    210                 215                 220                 


Asn Arg Pro Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln 
225                 230                 235                 240 


His Leu His Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys 
                245                 250                 255     


Phe Ser Ser Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp 
            260                 265                 270         


Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr 
        275                 280                 285             


His Ala Asn Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp 
    290                 295                 300                 


Thr Gln Tyr Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly 
305                 310                 315                 320 


Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro 
                325                 330                 335     


Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn 
            340                 345                 350         


Met Ile Val Arg Ser Cys Lys Cys Ser 
        355                 360     


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(24)
<223>  Natural leader sequence murine PD-1

<400>  47

Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu 
            20                  


<210>  48
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(145)
<223>  Murine PD-1 Extracellular domain

<400>  48

Leu Glu Val Pro Asn Gly Pro Trp Arg Ser Leu Thr Phe Tyr Pro Ala 
1               5                   10                  15      


Trp Leu Thr Val Ser Glu Gly Ala Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ser Asn Trp Ser Glu Asp Leu Met Leu Asn Trp Asn Arg Leu Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Glu Lys Gln Ala Ala Phe Cys Asn Gly Leu Ser Gln 
    50                  55                  60                  


Pro Val Gln Asp Ala Arg Phe Gln Ile Ile Gln Leu Pro Asn Arg His 
65                  70                  75                  80  


Asp Phe His Met Asn Ile Leu Asp Thr Arg Arg Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu His Pro Lys Ala Lys Ile Glu Glu 
            100                 105                 110         


Ser Pro Gly Ala Glu Leu Val Val Thr Glu Arg Ile Leu Glu Thr Ser 
        115                 120                 125             


Thr Arg Tyr Pro Ser Pro Ser Pro Lys Pro Glu Gly Arg Phe Gln Gly 
    130                 135                 140                 


Met 
145 


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  GAD65 (202-221)

<400>  49

Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Glu 
1               5                   10                  15      


Tyr Val Thr Leu 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Mete1 (16-35)

<400>  50

Glu Gln Gln Asn Lys Glu Ala Asn Asn Arg Ala Glu Lys Ser Glu Glu 
1               5                   10                  15      


Glu Val His Asn 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Mete1(46-65)

<400>  51

Asp Leu Asp Gln Val Gln Glu Ser Leu Leu Lys Ala Asn Asn Gln Leu 
1               5                   10                  15      


Val Glu Lys Asp 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Met e 1(76-95)

<400>  52

Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu Glu Asp Leu Glu Arg 
1               5                   10                  15      


Ser Glu Glu Arg 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Met e 1(136-155)

<400>  53

Asn Gln Leu Lys Glu Ala Arg Phe Leu Ala Glu Glu Ala Asp Arg Lys 
1               5                   10                  15      


Tyr Asp Glu Val 
            20  


<210>  54
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  Met e 1(210-230)

<400>  54

Ala Tyr Lys Glu Gln Ile Lys Thr Leu Thr Asn Lys Leu Lys Ala Ala 
1               5                   10                  15      


Glu Ala Arg Ala Glu 
            20      


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Met e 1(241-260)

<400>  55

Lys Glu Val Asp Arg Leu Glu Asp Glu Leu Val Asn Glu Lys Glu Lys 
1               5                   10                  15      


Tyr Lys Ser Ile 
            20  


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  linker

<400>  56

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser 
1               5                   10                  15      


Gln Gly Lys Gly Arg 
            20      


<210>  57
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  linker

<400>  57

Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser 
1               5                   10                  15      


Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu 
            20                  25                  30  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  linker

<400>  58

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                  


<210>  59
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1173)
<223>  Human transforming growth factor beta-1

<400>  59
atgccgccct ccgggctgcg gctgctgccg ctgctgctac cgctgctgtg gctactggtg       60

ctgacgcctg gccggccggc cgcgggacta tccacctgca agactatcga catggagctg      120

gtgaagcgga agcgcatcga ggccatccgc ggccagatcc tgtccaagct gcggctcgcc      180

agccccccga gccaggggga ggtgccgccc ggcccgctgc ccgaggccgt gctcgccctg      240

tacaacagca cccgcgaccg ggtggccggg gagagtgcag aaccggagcc cgagcctgag      300

gccgactact acgccaagga ggtcacccgc gtgctaatgg tggaaaccca caacgaaatc      360

tatgacaagt tcaagcagag tacacacagc atatatatgt tcttcaacac atcagagctc      420

cgagaagcgg tacctgaacc cgtgttgctc tcccgggcag agctgcgtct gctgaggctc      480

aagttaaaag tggagcagca cgtggagctg taccagaaat acagcaacaa ttcctggcga      540

tacctcagca accggctgct ggcacccagc gactcgccag agtggttatc ttttgatgtc      600

accggagttg tgcggcagtg gttgagccgt ggaggggaaa ttgagggctt tcgccttagc      660

gcccactgct cctgtgacag cagggataac acactgcaag tggacatcaa cgggttcact      720

accggccgcc gaggtgacct ggccaccatt catggcatga accggccttt cctgcttctc      780

atggccaccc cgctggagag ggcccagcat ctgcaaagct cccggcaccg ccgagccctg      840

gacaccaact attgcttcag ctccacggag aagaactgct gcgtgcggca gctgtacatt      900

gacttccgca aggacctcgg ctggaagtgg atccacgagc ccaagggcta ccatgccaac      960

ttctgcctcg ggccctgccc ctacatttgg agcctggaca cgcagtacag caaggtcctg     1020

gccctgtaca accagcataa cccgggcgcc tcggcggcgc cgtgctgcgt gccgcaggcg     1080

ctggagccgc tgcccatcgt gtactacgtg ggccgcaagc ccaaggtgga gcagctgtcc     1140

aacatgatcg tgcgctcctg caagtgcagc tga                                  1173


<210>  60
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(390)
<223>  Human transforming growth factor beta-1

<400>  60

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  61
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1329)
<223>  Human transforming growth factor beta 2 (TGFB2)

<400>  61
atgcactact gtgtgctgag cgcttttctg atcctgcatc tggtcacggt cgcgctcagc       60

ctgtctacct gcagcacact cgatatggac cagttcatgc gcaagaggat cgaggcgatc      120

cgcgggcaga tcctgagcaa gctgaagctc accagtcccc cagaagacta tcctgagccc      180

gaggaagtcc ccccggaggt gatttccatc tacaacagca ccagggactt gctccaggag      240

aaggcgagcc ggagggcggc cgcctgcgag cgcgagagga gcgacgaaga gtactacgcc      300

aaggaggttt acaaaataga catgccgccc ttcttcccct ccgaaactgt ctgcccagtt      360

gttacaacac cctctggctc agtgggcagc ttgtgctcca gacagtccca ggtgctctgt      420

gggtaccttg atgccatccc gcccactttc tacagaccct acttcagaat tgttcgattt      480

gacgtctcag caatggagaa gaatgcttcc aatttggtga aagcagagtt cagagtcttt      540

cgtttgcaga acccaaaagc cagagtgcct gaacaacgga ttgagctata tcagattctc      600

aagtccaaag atttaacatc tccaacccag cgctacatcg acagcaaagt tgtgaaaaca      660

agagcagaag gcgaatggct ctccttcgat gtaactgatg ctgttcatga atggcttcac      720

cataaagaca ggaacctggg atttaaaata agcttacact gtccctgctg cacttttgta      780

ccatctaata attacatcat cccaaataaa agtgaagaac tagaagcaag atttgcaggt      840

attgatggca cctccacata taccagtggt gatcagaaaa ctataaagtc cactaggaaa      900

aaaaacagtg ggaagacccc acatctcctg ctaatgttat tgccctccta cagacttgag      960

tcacaacaga ccaaccggcg gaagaagcgt gctttggatg cggcctattg ctttagaaat     1020

gtgcaggata attgctgcct acgtccactt tacattgatt tcaagaggga tctagggtgg     1080

aaatggatac acgaacccaa agggtacaat gccaacttct gtgctggagc atgcccgtat     1140

ttatggagtt cagacactca gcacagcagg gtcctgagct tatataatac cataaatcca     1200

gaagcatctg cttctccttg ctgcgtgtcc caagatttag aacctctaac cattctctac     1260

tacattggca aaacacccaa gattgaacag ctttctaata tgattgtaaa gtcttgcaaa     1320

tgcagctaa                                                             1329


<210>  62
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(442)
<223>  Human Transforming growth factor beta-2

<400>  62

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  63
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(930)
<223>  Human transforming growth factor beta 3 (TGFB3)

<400>  63
atgaagatgc acttgcaaag ggctctggtg gtcctggccc tgctgaactt tgccacggtc       60

agcctctctc tgtccacttg caccaccttg gacttcggcc acatcaagaa gaagagggtg      120

gaagccatta ggggacagat cttgagcaag ctcaggctca ccagcccccc tgagccaacg      180

gtgatgaccc acgtccccta tcaggtcctg gccctttaca acagcacccg ggagctgctg      240

gaggagatgc atggggagag ggaggaaggc tgcacccagg aaaacaccga gtcggaatac      300

tatgccaaag aaatccataa attcgacatg atccaggggc tggcggagca caacgaactg      360

gctgtctgcc ctaaaggaat tacctccaag gttttccgct tcaatgtgtc ctcagtggag      420

aaaaatagaa ccaacctatt ccgagcagaa ttccgggtct tgcgggtgcc caaccccagc      480

tctaagcgga atgagcagag gatcgagctc ttccagatcc ttcggccaga tgagcacatt      540

gccaaacagc gctatatcgg tggcaagaat ctgcccacac ggggcactgc cgagtggctg      600

tcctttgatg tcactgacac tgtgcgtgag tggctgttga gaagagagtc caacttaggt      660

ctagaaatca gcattcactg tccatgtcac acctttcagc ccaatggaga tatcctggaa      720

aacattcacg aggtgatgga aatcaaattc aaaggcgtgg acaatgagga tgaccatggc      780

cgtggagatc tggggcgcct caagaagcag aaggatcacc acaaccctca tctaatcctc      840

atgatgattc ccccacaccg gctcgacaac ccgggccagg ggggtcagag gaagaagcgg      900

gctttggaca ccaattactg cttccggtga                                       930


<210>  64
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(309)
<223>  Human transforming growth factor beta-3

<400>  64

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg 
305                 


<210>  65
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(537)
<223>  Human interleukin 10 (IL10)

<400>  65
atgcacagct cagcactgct ctgttgcctg gtcctcctga ctggggtgag ggccagccca       60

ggccagggca cccagtctga gaacagctgc acccacttcc caggcaacct gcctaacatg      120

cttcgagatc tccgagatgc cttcagcaga gtgaagactt tctttcaaat gaaggatcag      180

ctggacaact tgttgttaaa ggagtccttg ctggaggact ttaagggtta cctgggttgc      240

caagccttgt ctgagatgat ccagttttac ctggaggagg tgatgcccca agctgagaac      300

caagacccag acatcaaggc gcatgtgaac tccctggggg agaacctgaa gaccctcagg      360

ctgaggctac ggcgctgtca tcgatttctt ccctgtgaaa acaagagcaa ggccgtggag      420

caggtgaaga atgcctttaa taagctccaa gagaaaggca tctacaaagc catgagtgag      480

tttgacatct tcatcaacta catagaagcc tacatgacaa tgaagatacg aaactga         537


<210>  66
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(178)
<223>  Human interleukin-10 isoform 1 precursor

<400>  66

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  67
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(282)
<223>  Human secretoglobin family 3A member 2 (SCGB3A2)

<400>  67
atgaagctgg taactatctt cctgctggtg accatcagcc tttgtagtta ctctgctact       60

gccttcctca tcaacaaagt gccccttcct gttgacaagt tggcaccttt acctctggac      120

aacattcttc cctttatgga tccattaaag cttcttctga aaactctggg catttctgtt      180

gagcaccttg tggaggggct aaggaagtgt gtaaatgagc tgggaccaga ggcttctgaa      240

gctgtgaaga aactgctgga ggcgctatca cacttggtgt ga                         282


<210>  68
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(93)
<223>  Human secretoglobin family 3A member 2 precursor

<400>  68

Met Lys Leu Val Thr Ile Phe Leu Leu Val Thr Ile Ser Leu Cys Ser 
1               5                   10                  15      


Tyr Ser Ala Thr Ala Phe Leu Ile Asn Lys Val Pro Leu Pro Val Asp 
            20                  25                  30          


Lys Leu Ala Pro Leu Pro Leu Asp Asn Ile Leu Pro Phe Met Asp Pro 
        35                  40                  45              


Leu Lys Leu Leu Leu Lys Thr Leu Gly Ile Ser Val Glu His Leu Val 
    50                  55                  60                  


Glu Gly Leu Arg Lys Cys Val Asn Glu Leu Gly Pro Glu Ala Ser Glu 
65                  70                  75                  80  


Ala Val Lys Lys Leu Leu Glu Ala Leu Ser His Leu Val 
                85                  90              


<210>  69
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(723)
<223>  Human immunoglobulin superfamily member 11 (IGSF11) Extracellular
       domain

<400>  69
atgacttctc agcgttcccc tctggcgcct ttgctgctcc tctctctgca cggtgttgca       60

gcatccctgg aagtgtcaga gagccctggg agtatccagg tggcccgggg tcagccagca      120

gtcctgccct gcactttcac taccagcgct gccctcatta acctcaatgt catttggatg      180

gtcactcctc tctccaatgc caaccaacct gaacaggtca tcctgtatca gggtggacag      240

atgtttgatg gtgccccccg gttccacggt agggtaggat ttacaggcac catgccagct      300

accaatgtct ctatcttcat taataacact cagttatcag acactggcac ctaccagtgc      360

ctggtcaaca accttccaga catagggggc aggaacattg gggtcaccgg tctcacagtg      420

ttagttcccc cttctgcccc acactgccaa atccaaggat cccaggatat tggcagcgat      480

gtcatcctgc tctgtagctc agaggaaggc attcctcgac caacttacct ttgggagaag      540

ttagacaata ccctcaaact acctccaaca gctactcagg accaggtcca gggaacagtc      600

accatccgga acatcagtgc cctgtcttca ggtttgtacc agtgcgtggc ttctaatgct      660

attggaacca gcacctgtct tctggatctc caggttattt caccccagcc caggaacatt      720

gga                                                                    723


<210>  70
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(431)
<223>  Human immunoglobulin superfamily member 11 i (IGSF11) 
       Extracellular domain

<400>  70

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly 
    


<210>  71
<211>  483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Human cytotoxic T-lymphocyte associated protein 4 (CTLA4) 
       Extracellular Domain

<400>  71
atggcttgcc ttggatttca gcggcacaag gctcagctga acctggctac caggacctgg       60

ccctgcactc tcctgttttt tcttctcttc atccctgtct tctgcaaagc aatgcacgtg      120

gcccagcctg ctgtggtact ggccagcagc cgaggcatcg ccagctttgt gtgtgagtat      180

gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc tgacagccag      240

gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt cctagatgat      300

tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg      360

gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc gccatactac      420

ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg cccagattct      480

gac                                                                    483


<210>  72
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(161)
<223>  CTLA4 HUMAN Cytotoxic T-lymphocyte protein 4 Extracellular Domain

<400>  72

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp 
    


<210>  73
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(510)
<223>  Human programmed cell death 1 (PDCD1) extracellular domain

<400>  73
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg                                       510


<210>  74
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(170)
<223>  Human programmed cell death protein 1

<400>  74

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 170 


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  75

Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  76

Gly Gly Gly Ser Gly 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  77

Gly Gly Ser Gly Gly 
1               5   


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  linker

<400>  78

Ser Gly Ser Ser Gly Ser 
1               5       


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  79

Gly Gly Gly Gly Ser 
1               5   


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  81

Gly Gly Gly Gly Ser 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  82

Gly Gly Gly Ser Ser 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  83

Gly Gly Gly Ser Gly 
1               5   


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  84

Ser Gly Ser Ser Gly Ser 
1               5       


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  85

Leu Gly Gly Gly Ser 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  86

Gly Leu Gly Gly Ser 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  87

Gly Gly Leu Gly Ser 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  88

Gly Gly Gly Leu Ser 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  89

Gly Gly Gly Gly Leu 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  90

Leu Gly Gly Ser Gly 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  91

Gly Leu Gly Ser Gly 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  92

Gly Gly Leu Ser Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  93

Gly Gly Gly Leu Gly 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  94

Gly Gly Gly Ser Leu 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  95

Leu Gly Gly Ser Ser 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  96

Gly Leu Gly Ser Ser 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  97

Gly Gly Leu Ser Ser 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  98

Leu Gly Leu Gly Ser 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  99

Gly Leu Gly Leu Ser 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  100

Gly Leu Leu Gly Ser 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  101

Leu Gly Gly Leu Ser 
1               5   


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  102

Gly Leu Gly Gly Leu 
1               5   


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  103

Leu Gly Leu Ser Gly 
1               5   


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  104

Gly Leu Leu Ser Gly 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  105

Gly Gly Leu Ser Leu 
1               5   


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  106

Gly Gly Leu Leu Gly 
1               5   


<210>  107
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  107

Gly Leu Gly Ser Leu 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  108

Leu Gly Leu Ser Ser 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  109

Gly Gly Leu Leu Ser 
1               5   


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  110

Leu Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  111

Gly Leu Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  112

Gly Gly Leu Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  113

Gly Gly Gly Leu Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  114

Gly Gly Gly Gly Leu Gly Gly Gly Gly Ser 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  115

Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  116

Gly Leu Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  117

Gly Gly Leu Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  118

Gly Gly Gly Leu Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  119

Gly Gly Gly Ser Leu Gly Gly Gly Ser Gly 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  120

Leu Gly Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  121

Gly Leu Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  122

Gly Gly Leu Ser Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  123

Gly Gly Gly Leu Ser Gly Gly Gly Ser Ser 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  124

Gly Gly Gly Ser Leu Gly Gly Gly Ser Ser 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  125

Leu Gly Gly Gly Ser Leu Gly Gly Gly Ser 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  126

Gly Leu Gly Gly Ser Gly Leu Gly Gly Ser 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  127

Gly Gly Leu Gly Ser Gly Gly Leu Gly Ser 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  128

Gly Gly Gly Leu Ser Gly Gly Gly Leu Ser 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  129

Gly Gly Gly Gly Leu Gly Gly Gly Gly Leu 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  130

Leu Gly Gly Ser Gly Leu Gly Gly Ser Gly 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  131

Gly Leu Gly Ser Gly Gly Leu Gly Ser Gly 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  132

Gly Gly Leu Ser Gly Gly Gly Leu Ser Gly 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  133

Gly Gly Gly Leu Gly Gly Gly Gly Leu Gly 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  134

Gly Gly Gly Ser Leu Gly Gly Gly Ser Leu 
1               5                   10  


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  135

Leu Gly Gly Ser Ser Leu Gly Gly Ser Ser 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  136

Gly Leu Gly Ser Ser Gly Leu Gly Ser Ser 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  137

Gly Gly Leu Ser Ser Gly Gly Leu Ser Ser 
1               5                   10  


<210>  138
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  linker

<400>  138

Gly Ser Gly Gly Gly Ala 
1               5       


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  linker

<400>  139

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala 
1               5                   10          


<210>  140
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  linker

<400>  140

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala 
        


<210>  141
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(24)
<223>  linker

<400>  141

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Gly Ser Gly Gly Gly Ala 
            20                  


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  142

Gly Glu Asn Leu Tyr Phe Gln Ser Gly Gly 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  143

Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  144

Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  145

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  146

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  linker

<400>  147

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  148
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  linker

<400>  148

Gly Gly Gly Ser Ser Ser 
1               5       


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  linker

<400>  149

Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser 
1               5                   10                  15  


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  linker

<400>  150

Gly Leu Gly Gly Leu Ala Ala Ala 
1               5               


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  linker

<400>  151

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu Gly Gly Leu 
1               5                   10                  15      


<210>  152
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  linker

<400>  152

Ser Leu Ser Leu Ser Pro Gly Lys Gly Leu Gly Gly Leu 
1               5                   10              


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  153

Gly Pro Gly Pro Gly 
1               5   


<210>  154
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(36)
<223>  linker

<400>  154

Gly Gly Ser Ala Gly Gly Ser Gly Ser Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Ala Ser Gly Thr Gly Thr Ala Gly Gly Thr Gly Ser Gly Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly 
        35      


<210>  155
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(36)
<223>  linker

<400>  155

Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
1               5                   10                  15      


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  linker

<400>  156

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  157
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(333)
<223>  hinge region derived from IgM

<400>  157
gccgaactcc cgcccaaggt gtccgtgttc gtccctcccc gcgatgggtt cttcggcaat       60

ccacgaaaat ccaaactgat ttgtcaggcc accggcttct ccccccgaca gatccaggtg      120

agttggctac gagagggtaa acaggtgggg agcggagtga ccactgacca ggtgcaggcc      180

gaggccaagg aaagcggacc cacaacatac aaagtgacaa gcactctgac gattaaggag      240

tcagactggc tcggccaatc catgtttaca tgccgggttg atcacagagg gttgaccttc      300

caacagaacg catccagtat gtgcgttcca gat                                   333


<210>  158
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(180)
<223>  trimerization unit

<400>  158
gctgggcagg tgaggatctg ggccacatac cagaccatgc tggacaagat ccgggaggtg       60

ccggagggct ggctcatctt tgtggccgag agggaagagc tctatgtacg cgttagaaat      120

ggcttccgga aggtgctgct ggaggcccgg acagccctcc cgagaggcac gggcaatgag      180


<210>  159
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(27)
<223>  trimerization unit

<400>  159

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  160
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(117)
<223>  tetramerization unit

<400>  160
aagcctctgg acggagagta tttcactctc cagatccggg gccccgaaag gttcgaaatg       60

ttccgggagc ttaacgaggc cttggagctg aaagacgcac aggccggaaa ggaaccg         117


<210>  161
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  161

Gly Gly Ser Gly Gly 
1               5   


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  162

Gly Leu Gly Gly Leu 
1               5   


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  linker

<400>  163

Lys Pro Glu Pro Lys Pro Ala Pro Ala Pro Lys Pro 
1               5                   10          


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  linker

<400>  164

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The sequence can be repeated m times, wherein m is an integer 
       from 1 to 5, e.g., 1, 2, 3, 4, or 5.

<400>  165

Glu Ala Ala Ala Lys Gly Ser 
1               5           


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  linker

<400>  166

Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
1               5                   10                  15  


<210>  167
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  linker

<400>  167

Ser Ala Cys Tyr Cys Glu Leu Ser 
1               5               


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  linker

<400>  168

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  169
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  linker

<400>  169

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(29)
<223>  linker

<400>  170

Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly 
1               5                   10                  15      


His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
            20                  25                  


<210>  171
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  linker

<400>  171

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                  


