                         SEQUENCE LISTING

<110>   CNRS
       INSERM (Institut National de la Sant et de la Recherche
       UNIVERSITE COTE D'AZUR
 
<120>  New humanized anti-VEGFC antibodies and uses thereof

<130>  381398D41423

<140>  FR21305606.2
<141>  2021-05-11

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  artificial

<220>
<223>  mature peptide of the amino acid sequence of the human VEGFC

<400>  1

Ala His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg 
1               5                   10                  15      


Lys Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu 
            20                  25                  30          


Phe Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr 
        35                  40                  45              


Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr 
    50                  55                  60                  


Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu 
65                  70                  75                  80  


Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser 
                85                  90                  95      


Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile 
            100                 105                 110         


Ile Arg Arg 
        115 


<210>  2
<211>  358
<212>  DNA
<213>  artificial

<220>
<223>  nucleic sequence of the variable region heavy chain of the 1E9 
       antibodies

<400>  2
ccaggcccaa ctgcggcagc ctggggctga actggtgaag cctggggctt cagtgaagct       60

gtcctgcaag gcttctggct acaccttcat cagctactgg atgcactggg tgaaacagag      120

gcctggacaa ggccttgagt ggattggaga gattaatcct agcaacggtc gtactaacta      180

caatgagaag ttcaagagca aggccacact gactgtagac agatcctcca gcacagccta      240

catgcaactc agcagcctga catctgagga ctctgcggtc tattactgtg caagcacctc      300

tctcttttac tatgctatga attactgggg tcaaggaacc tcagtcaccg tctcctca        358


<210>  3
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  nucleic sequence of the variable region light chain  of the 1E9 
       antibodies

<400>  3
gatgttgtga tgacccaaac tccactctcc ctgactgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccgaag ctcctgatct acaaagtttt caaccgattg      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tatttctgct ctcaaaatac gcatgttccg      300

tggacgttcg gtggaggcac caagttggaa atcaaa                                336


<210>  4
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of the heavy chain variable region (VH)  of 
       the 1E9 antibodies

<400>  4

Gln Ala Gln Leu Arg Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of the light chain variable region (VL)  of 
       the 1E9 antibodies

<400>  5

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  6
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR1-H  of the heavy chain of the 1E9 
       antibodies based on Kabat

<400>  6

Ser Tyr Trp Met His 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR2-H   of the heavy chain of the 1E9 
       antibodies  based on Kabat

<400>  7

Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  8
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR3-H   of the heavy chain of the 1E9 
       antibodies  based on Kabat

<400>  8

Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr 
1               5                   10  


<210>  9
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR1-L  of the light chain of the 1E9 
       antibodies  based on Kabat

<400>  9

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR2-L  of the light chain of the 1E9 
       antibodies  based on Kabat

<400>  10

Lys Val Phe Asn Arg Leu Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  highly variable region CDR3-L of the light chain of the 1E9 
       antibodies  based on Kabat

<400>  11

Ser Gln Asn Thr His Val Pro Trp Thr 
1               5                   


<210>  12
<211>  419
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  amino-acid sequence of the human VEGFC

<400>  12

Met His Leu Leu Gly Phe Phe Ser Val Ala Cys Ser Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Leu Pro Gly Pro Arg Glu Ala Pro Ala Ala Ala Ala Ala Phe 
            20                  25                  30          


Glu Ser Gly Leu Asp Leu Ser Asp Ala Glu Pro Asp Ala Gly Glu Ala 
        35                  40                  45              


Thr Ala Tyr Ala Ser Lys Asp Leu Glu Glu Gln Leu Arg Ser Val Ser 
    50                  55                  60                  


Ser Val Asp Glu Leu Met Thr Val Leu Tyr Pro Glu Tyr Trp Lys Met 
65                  70                  75                  80  


Tyr Lys Cys Gln Leu Arg Lys Gly Gly Trp Gln His Asn Arg Glu Gln 
                85                  90                  95      


Ala Asn Leu Asn Ser Arg Thr Glu Glu Thr Ile Lys Phe Ala Ala Ala 
            100                 105                 110         


His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg Lys 
        115                 120                 125             


Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu Phe 
    130                 135                 140                 


Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val Tyr Arg 
145                 150                 155                 160 


Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn Thr Ser 
                165                 170                 175     


Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro Leu Ser 
            180                 185                 190         


Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr Ser Cys 
        195                 200                 205             


Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser Ile Ile 
    210                 215                 220                 


Arg Arg Ser Leu Pro Ala Thr Leu Pro Gln Cys Gln Ala Ala Asn Lys 
225                 230                 235                 240 


Thr Cys Pro Thr Asn Tyr Met Trp Asn Asn His Ile Cys Arg Cys Leu 
                245                 250                 255     


Ala Gln Glu Asp Phe Met Phe Ser Ser Asp Ala Gly Asp Asp Ser Thr 
            260                 265                 270         


Asp Gly Phe His Asp Ile Cys Gly Pro Asn Lys Glu Leu Asp Glu Glu 
        275                 280                 285             


Thr Cys Gln Cys Val Cys Arg Ala Gly Leu Arg Pro Ala Ser Cys Gly 
    290                 295                 300                 


Pro His Lys Glu Leu Asp Arg Asn Ser Cys Gln Cys Val Cys Lys Asn 
305                 310                 315                 320 


Lys Leu Phe Pro Ser Gln Cys Gly Ala Asn Arg Glu Phe Asp Glu Asn 
                325                 330                 335     


Thr Cys Gln Cys Val Cys Lys Arg Thr Cys Pro Arg Asn Gln Pro Leu 
            340                 345                 350         


Asn Pro Gly Lys Cys Ala Cys Glu Cys Thr Glu Ser Pro Gln Lys Cys 
        355                 360                 365             


Leu Leu Lys Gly Lys Lys Phe His His Gln Thr Cys Ser Cys Tyr Arg 
    370                 375                 380                 


Arg Pro Cys Thr Asn Arg Gln Lys Ala Cys Glu Pro Gly Phe Ser Tyr 
385                 390                 395                 400 


Ser Glu Glu Val Cys Arg Cys Val Pro Ser Tyr Trp Lys Arg Pro Gln 
                405                 410                 415     


Met Ser Leu 
            


<210>  13
<211>  119
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  full length amino acid sequence of heavy chain human germline 
       IGHV1-46*01

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus amino acid sequence of humanized heavy chain 
       1E9-1-46-VHA based on human germline IGHV1-46*01


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  I or M

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  L or M

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  A or V

<400>  14

Gln Xaa Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Xaa Thr Val Asp Arg Ser Thr Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA1

<400>  15

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA2

<400>  16

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>   humanized heavy chain 1E9-1-46-VHA3

<400>  17

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA4

<400>  18

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA5

<400>  19

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA6

<400>  20

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA7

<400>  21

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA8

<400>  22

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA9

<400>  23

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA10

<400>  24

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA11

<400>  25

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA12

<400>  26

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA13

<400>  27

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA14

<400>  28

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  29
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA15

<400>  29

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA16

<400>  30

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>   humanized heavy chain 1E9-1-46-VHA17

<400>  31

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA18

<400>  32

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  33
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA19

<400>  33

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  34
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA20

<400>  34

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA21

<400>  35

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA22

<400>  36

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA23

<400>  37

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA24

<400>  38

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  39
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA25

<400>  39

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA26

<400>  40

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA27

<400>  41

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA28

<400>  42

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA29

<400>  43

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA30

<400>  44

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA31

<400>  45

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHA32

<400>  46

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  47
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus amino acid sequence of humanized heavy chain 
       1E9-1-46-VHB based on human germline IGHV1-46*01


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  I or M

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  L or M

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  A or V

<400>  47

Gln Xaa Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Thr Val Asp Arg Ser Thr Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  48
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB1

<400>  48

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB2

<400>  49

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB3

<400>  50

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB4

<400>  51

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB5

<400>  52

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB6

<400>  53

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB7

<400>  54

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB8

<400>  55

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB9

<400>  56

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB10

<400>  57

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB11

<400>  58

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB12

<400>  59

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB13

<400>  60

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB14

<400>  61

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB15

<400>  62

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB16

<400>  63

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  64
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB17

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB18

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB19

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB20

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  68
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB21

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB22

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB23

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  71
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB24

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB25

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  73
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB26

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  74
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB27

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB28

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB29

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  77
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB30

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  78
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB31

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  79
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB32

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  80
<211>  120
<212>  PRT
<213>  artificial

<220>
<223>  Full length heavy chain VH human germline IGHV1-2*06

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus amino acid sequence of humanized heavy chain 
       1E9-1-2-VHA based on human germline IGHV1-2*06


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  I or M

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  L or M

<400>  81

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Xaa Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  82
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA1

<400>  82

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA2

<400>  83

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  84
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA3

<400>  84

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  85
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA4

<400>  85

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  86
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA5

<400>  86

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  87
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA6

<400>  87

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA7

<400>  88

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  89
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA8

<400>  89

Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  90
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus amino acid sequence of humanized heavy chain 
       1E9-1-2-VHB based on human germline IGHV1-2*06


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  I or M

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  L or M

<400>  90

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  91
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB1

<400>  91

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  92
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB2

<400>  92

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  93
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB3

<400>  93

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  94
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB4

<400>  94

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  95
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB5

<400>  95

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  96
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB6

<400>  96

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  97
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB7

<400>  97

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  98
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHB8

<400>  98

Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  99
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  full length heavy chain VH human germline IGHV4-34*08

<400>  99

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  100
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence amino acid sequence of humanized heavy chain 
       1E9-4-34*08 VHA based on human germline IGHV4-34*08


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  S or I

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  I or L

<400>  100

Gln Xaa Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  101
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA1

<400>  101

Gln Ala Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  102
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA2

<400>  102

Gln Ala Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  103
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA3

<400>  103

Gln Ala Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  104
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA4

<400>  104

Gln Ala Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  105
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA5

<400>  105

Gln Val Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  106
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA6

<400>  106

Gln Val Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  107
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA7

<400>  107

Gln Val Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  108
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*08-VHA8

<400>  108

Gln Val Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  109
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  full Length heavy chain VH human germline IGHV4-34*09

<400>  109

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  110
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence amino acid sequence of humanized heavy chain 
       1E9-4-34*09 VHA based on human germline IGHV4-34*09


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  S or I

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  I or L

<400>  110

Gln Xaa Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  111
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA1

<400>  111

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  112
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA2

<400>  112

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  113
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA3

<400>  113

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  114
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA4

<400>  114

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA5

<400>  115

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  116
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA6

<400>  116

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  117
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA7

<400>  117

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  118
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHA8

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  119
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence amino acid sequence of humanized heavy chain 
       1E9-4-34*09 VHB based on human germline IGHV4-34*09


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  S or I

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  I or L

<400>  119

Gln Xaa Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  120
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB1

<400>  120

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  121
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB2

<400>  121

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB3

<400>  122

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  123
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB4

<400>  123

Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  124
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB5

<400>  124

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  125
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB6

<400>  125

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  126
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB7

<400>  126

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  127
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-4-34*09-VHB8

<400>  127

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  128
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Full length light chain VL human germline IGKV2-30*02

<400>  128

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  129
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence amino acid sequence of humanized light chain 
       1E9-2-30-VL


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Y or F

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  F or Y

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring amino acid

<400>  129

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Xaa Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Xaa Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  130
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30-VLA1

<400>  130

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  131
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30-VLA2

<400>  131

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  132
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30-VLA3

<400>  132

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  133
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30-VLA4

<400>  133

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  134
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Full Length  light chain VL human germline IGKV2-18*01

<400>  134

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn His Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  135
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Consensus sequence amino acid sequence of humanized light chain 
       1E9-2-18-VL VHB based on human germline IGKV2-18*01


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  T or S

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Y or F

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Asp Xaa Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Xaa Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Xaa Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  136
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA1

<400>  136

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  137
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA2

<400>  137

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  138
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA3

<400>  138

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  139
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA4

<400>  139

Asp Val Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  140
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA5

<400>  140

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  141
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA6

<400>  141

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  142
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA7

<400>  142

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  143
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-18-VLA8

<400>  143

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Pro Val Asn Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Trp Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  144
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Global consensus amino acid sequence of humanized heavy chain VH 
       based on human germlines IGHV1-46*01 and IGHV1-2*06


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S or P

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  I or M

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  L or M

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  I or T

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  A or V

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  R or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  D or E

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Gln Xaa Gln Leu Val Gln Xaa Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Xaa Thr Xaa Thr Val Asp Xaa Ser Xaa Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  145
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  Global consensus amino acid sequence of humanized heavy chain VH 
       based on human germlines IGHV4-34*08 and IGHV4-34*09


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  E or Q

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  P or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  I or P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  V or L

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  E or Q

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  S or I

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  F or L

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  I or L

<400>  145

Gln Xaa Gln Leu Gln Xaa Xaa Gly Xaa Gly Leu Xaa Lys Pro Ser Xaa 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe Xaa Ser Tyr 
            20                  25                  30          


Trp Met His Trp Xaa Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Xaa 
    50                  55                  60                  


Lys Ser Arg Val Thr Xaa Ser Val Asp Arg Ser Lys Asn Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  146
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  Global consensus amino acid sequence of humanized light chain VL 
       based on human germlines IGKV2-30*02 and IGKV2-18*01


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  P or L

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  N or T

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  P or L

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  E or Q

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  L or Q

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Q or R

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  R or W

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Y or F

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring amino acid

<400>  146

Asp Xaa Val Met Thr Gln Xaa Pro Xaa Ser Leu Pro Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Xaa Xaa Gln Xaa Pro Gly Gln Ser 
        35                  40                  45              


Pro Xaa Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Xaa Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Xaa Val Glu Ala Glu Asp Val Gly Val Tyr Xaa Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  147
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Global consensus amino acid sequence of humanized heavy chain VH


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  R or V or Q

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  P or S


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  A or P

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  E or G

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  V or K

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  G or S

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  A or Q

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  V or L

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  K or S

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  K or A

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  S or Y

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  R or A or P

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  F or L

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  A or V

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  S or T or K

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  T or Q

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Y or S

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  T or R

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  E or A

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  S or T

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  S or L

<400>  147

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Xaa Gln Xaa Gly Xaa Xaa Xaa Xaa Lys 
            20                  25                  30          


Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Ala Xaa Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Xaa Gln Xaa Pro Gly Xaa Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Xaa Lys Ser Lys Xaa Thr Leu Xaa Val Asp Arg Ser Xaa Xaa 
                85                  90                  95      


Xaa Ala Xaa Met Xaa Leu Ser Ser Xaa Xaa Xaa Xaa Asp Xaa Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Xaa Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  148
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  mouse amino acid sequence of the VH chain of 1E9  with secretion 
       signal and VH hIgG1 backbone

<400>  148

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Arg Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  149
<211>  239
<212>  PRT
<213>  artificial

<220>
<223>  mouse amino acid sequence of the VL chain of 1E9 with secretion 
       signal and VL kappa backbone

<400>  149

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Thr 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
            100                 105                 110         


Cys Ser Gln Asn Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  150
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46 VHA1 with secretion signal and VH 
       hIgG1 backbone

<400>  150

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Leu Thr Val Asp Arg Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  151
<211>  239
<212>  PRT
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30 VLA1 with secretion signal and VL 
       kappa backbone

<400>  151

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Ser Gln Asn Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  152
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB1 with secretion signal and VH 
       hIgG1 backbone

<400>  152

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Val Thr Leu Thr Val Asp Arg Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  153
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46-VHB2 with secretion signal and VH 
       hIgG1 backbone

<400>  153

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Val Thr Met Thr Val Asp Arg Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  154
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-2-VHA1 with secretion signal and VH 
       hIgG1 backbone

<400>  154

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  155
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-1-2-VHB1 with secretion signal and VH 
       hIgG1 backbone

<400>  155

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  156
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*08-VHA1 with secretion signal and 
       VH hIgG1 backbone

<400>  156

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Gln Gln Pro Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Gln Ala Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  157
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHA1 with secretion signal and 
       VH hIgG1 backbone

<400>  157

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Leu Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Gln Ala Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  158
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHB1 with secretion signal and 
       VH hIgG1 backbone

<400>  158

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe 
        35                  40                  45              


Ile Ser Tyr Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Leu Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Gln Ala Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  159
<211>  468
<212>  PRT
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHB2 with secretion signal and 
       VH hIgG1 backbone

<400>  159

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ala Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Tyr Trp Met His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Leu Lys Ser Arg Val Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Gln Ala Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Thr Ser Leu Phe Tyr Tyr Ala Met Asn Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  160
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  mouse nucleic sequence of the VH chain of 1E9 with secretion 
       signal and VH hIgG1 backbone

<400>  160
atgaagcacc tgtggttctt cctgctgctg gtggccgctc cccggtgggt tctgtcccag       60

gctcagctga ggcagcccgg cgctgagctg gtgaagcccg gagcttccgt gaagctgtcc      120

tgcaaggcca gcggctacac cttcatcagc tattggatgc actgggtgaa gcagaggcct      180

ggccagggcc tggagtggat cggcgagatc aatccttcca acggccggac caattataac      240

gagaagttta agagcaaggc taccctgacc gtggatcggt ccagcagcac cgcctacatg      300

cagctgtcca gcctgacctc cgaggacagc gccgtgtact actgtgcttc taccagcctg      360

ttttattacg ccatgaacta ctggggccag ggcacctccg tgaccgtgag cagcgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  161
<211>  731
<212>  DNA
<213>  artificial

<220>
<223>  mouse nucleic sequence of the VL chain of 1E9 with secretion 
       signal and VL kappa backbone

<400>  161
atggtgctgc agacccaggt gtttatctcc ctgctgctgt ggatcagcgg cgcctacggc       60

gacgtggtca tgacccagac ccctctgagc ctgaccgtga gcctgggcga ccaggcttcc      120

atcagctgcc ggtccagcca gagcctggtg cactccaatg gcaataccta tctgcactgg      180

tacctgcaga agcctggcca gagccccaag ctgctgatct ataaggtgtt taataggctg      240

agcggcgtgc ctgaccggtt tagcggctcc ggcagcggca ccgactttac cctgaagatc      300

agcagggtgg aggctgagga cctgggcgtg tacttctgca gccagaacac ccacgtgccc      360

tggacctttg gcggcggcac caagctggag atcaagcgta cggtggctgc accttctgtg      420

ttcatcttcc ctccatctga tgagcagctg aagtctggaa ccgcatctgt cgtctgtctg      480

ctgaacaact tttaccccag ggaggctaag gtccaatgga aggtggacaa cgccctgcag      540

tctggtaata gccaggaaag cgtgaccgaa caggattcca aggactccac ctactccctg      600

tcctccacac tgacactgag caaagccgac tatgaaaagc acaaagtgta tgcctgcgag      660

gtcactcatc agggcctgtc cagccccgtg actaaaagct ttaatagggg ggagtgctga      720

gcggccgcta a                                                           731


<210>  162
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  humanized heavy chain 1E9-1-46 VHA1 with secretion signal and VH 
       hIgG1 backbone

<400>  162
atgaagcacc tgtggttttt cctgctgctg gtggctgccc cccggtgggt tctgagccag       60

gctcagctgg tgcagcctgg cgccgaggtg aagaagcccg gcgcttccgt gaaggtgagc      120

tgtaaggctt ccggctacac ctttatctcc tattggatgc actgggtgag gcaggccccc      180

ggccagggat tggagtggat cggcgagatc aatccttcca atggccggac caattacaac      240

gagaagttta agtcccgggc taccctgacc gtggaccggt ccacctccac cgcctacatg      300

gagctgtcct ccctgcggag cgaggatacc gccgtgtact actgtgccag caccagcctg      360

ttctattatg ccatgaacta ttggggccag ggcaccctgg tgaccgtgtc ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  163
<211>  731
<212>  DNA
<213>  artificial

<220>
<223>  humanized light chain 1E9-2-30 VLA1 with secretion signal and VL 
       kappa backbone

<400>  163
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctccgg cgcttatggc       60

gatgtggtca tgacccagtc ccctctgagc ctgcctgtga ccctgggcca gcccgcttcc      120

atctcctgtc ggagctccca gagcctggtg cactccaacg gcaataccta tctgcactgg      180

taccagcaga ggcctggcca gagccccagg ctgctgatct acaaggtgtt taatcggctg      240

tccggcgtgc ctgataggtt ctccggcagc ggcagcggca ccgatttcac cctgaagatc      300

tcccgggtgg aggctgagga cgtgggcgtg tacttctgct cccagaacac ccacgtgcct      360

tggaccttcg gccagggcac caagctggag atcaagcgta cggtggctgc accttctgtg      420

ttcatcttcc ctccatctga tgagcagctg aagtctggaa ccgcatctgt cgtctgtctg      480

ctgaacaact tttaccccag ggaggctaag gtccaatgga aggtggacaa cgccctgcag      540

tctggtaata gccaggaaag cgtgaccgaa caggattcca aggactccac ctactccctg      600

tcctccacac tgacactgag caaagccgac tatgaaaagc acaaagtgta tgcctgcgag      660

gtcactcatc agggcctgtc cagccccgtg actaaaagct ttaatagggg ggagtgctga      720

gcggccgcta a                                                           731


<210>  164
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-1-46-VHB1 with secretion signal and VH 
       hIgG1 backbone

<400>  164
atgaagcacc tgtggttttt cctgctgctg gtggctgccc cccggtgggt tctgagccag       60

gctcagctgg tgcagcctgg cgccgaggtg aagaagcccg gcgcttccgt gaaggtgagc      120

tgtaaggctt ccggctacac ctttatctcc tattggatgc actgggtgag gcaggccccc      180

ggccagggat tggagtggat cggcgagatc aatccttcca atggccggac caattacaac      240

gagaagttta agtcccgggc taccctgacc gtggaccggt ccacctccac cgcctacatg      300

gagctgtcct ccctgcggag cgaggatacc gccgtgtact actgtgccag caccagcctg      360

ttctattatg ccatgaacta ttggggccag ggcaccctgg tgaccgtgtc ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  165
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-1-46-VHB2 with secretion signal and VH 
       hIgG1 backbone

<400>  165
atgaagcacc tgtggttttt cctgctgctg gtggccgctc cccggtgggt tctgtcccag       60

gctcagctgg tgcagtccgg cgctgaggtg aagaagcctg gcgcttccgt gaaggtgtcc      120

tgtaaggcct ccggctatac ctttatcagc tactggatgc actgggtgag gcaggcccct      180

ggccagggac tggagtggat gggcgagatc aatcccagca acggccggac caattacaat      240

gagaagttta agtcccgggt gaccatgacc gtggaccgga gcacctccac cgcctatatg      300

gagctgtcca gcctgaggag cgaggatacc gccgtgtact actgcgcttc taccagcctg      360

ttctattacg ccatgaacta ctggggccag ggcaccctgg tgaccgtgtc ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  166
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-1-2-VHA1 with secretion signal and VH 
       hIgG1 backbone

<400>  166
atgaagcacc tgtggttttt cctgctgctg gtggctgccc ctaggtgggt gctgtctcag       60

gcccagctgg tgcagcccgg cgctgaagtg aagaagcccg gcgcttccgt gaaggtgtcc      120

tgcaaggcct ccggctacac cttcatctcc tattggatgc actgggtgag gcaggcccct      180

ggccagggac tggagtggat cggcgagatc aaccccagca atggcaggac caattataat      240

gagaagttta agtccagggc taccctgacc gtggataagt ccatcagcac cgcctatatg      300

gagctgtccc ggctgaggtc cgacgacacc gccgtgtact attgcgcttc taccagcctg      360

ttctattatg ctatgaatta ctggggccag ggcaccctgg tgaccgtgtc ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  167
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-1-2-VHB1 with secretion signal and VH 
       hIgG1 backbone

<400>  167
atgaagcacc tgtggttctt tctgctgctg gtggctgccc ccaggtgggt gctgtctcag       60

gcccagctgg tgcagagcgg cgctgaggtg aagaagcccg gcgcctccgt gaaggtgtcc      120

tgcaaggcct ccggctatac cttcatcagc tattggatgc actgggtgag gcaggctccc      180

ggccagggac tggagtggat cggcgagatc aatccctcca acggcaggac caattataac      240

gagaagttca agagcagggt gaccctgacc gtggacaaga gcatctccac cgcctatatg      300

gagctgagcc ggctgaggag cgacgatacc gctgtgtatt attgcgcttc cacctccctg      360

ttttattacg ccatgaatta ttggggccag ggcaccctgg tgaccgtgag ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  168
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*08-VHA1 with secretion signal and 
       VH hIgG1 backbone

<400>  168
atgaagcacc tgtggttttt cctgctgctg gtggctgctc ctaggtgggt gctgtcccag       60

gcccagctgc agcagcccgg agctggactg ctgaagccta gcgagaccct gagcctgacc      120

tgcgccgcct acggctatac ctttatctcc tactggatgc actgggtgag gcagcccccc      180

ggcaagggac tggagtggat cggcgagatc aaccctagca atggccggac caactataac      240

gagaagttta agagccgggt gaccctgtcc gtggacaggt ccaagaatca ggcttccctg      300

aagctgagct ccgtgaccgc tgctgacacc gccgtgtact actgtgcctc cacctccctg      360

ttctattacg ccatgaatta ctggggccag ggcaccctgg tgaccgtgtc cagcgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  169
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHA1 with secretion signal and 
       VH hIgG1 backbone

<400>  169
atgaagcacc tgtggttttt tctgctgctg gtggctgctc ctaggtgggt gctgagccag       60

gctcagctgc aggagagcgg ccctggcctg gtgaagccca gccagaccct gtccctgacc      120

tgtgctgcct atggctacac ctttatctcc tactggatgc actgggtgcg gcagcctcct      180

ggcaagggcc tggagtggat cggcgagatc aatccttcca acggcaggac caactataac      240

gagaagctga agtccagggt gaccctgtcc gtggatcggt ccaagaacca ggcctccctg      300

aagctgtcct ccgtgaccgc cgctgacacc gctgtgtatt attgcgcctc caccagcctg      360

ttttactatg ccatgaacta ctggggccag ggcaccctgg tgaccgtgag ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  170
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHB1 with secretion signal and 
       VH hIgG1 backbone

<400>  170
atgaagcacc tgtggttctt tctgctgctg gtggctgctc ctcggtgggt gctgagccag       60

gctcagctgc aggagtccgg ccccggactg gtgaagccct cccagaccct gagcctgacc      120

tgcgctgcct atggctatac cttcatcagc tactggatgc actggatcag gcagcctcct      180

ggcaagggcc tggagtggat cggcgagatc aaccccagca acggccggac caattataac      240

gagaagctga agtccagggt gaccctgtcc gtggaccggt ccaagaatca ggcttccctg      300

aagctgagca gcgtgaccgc cgccgacacc gctgtgtatt attgcgcttc tacctccctg      360

ttctattacg ctatgaatta ttggggccag ggcaccctgg tgaccgtgtc ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


<210>  171
<211>  1418
<212>  DNA
<213>  artificial

<220>
<223>  Humanized heavy chain 1E9-4-34*09-VHB2 with secretion signal and 
       VH hIgG1 backbone

<400>  171
atgaagcacc tgtggttctt cctgctgctg gtggctgccc ccaggtgggt gctgagccag       60

gctcagctgc aggagagcgg ccccggactg gtgaagccta gccagaccct gagcctgacc      120

tgcgccgcct atggctatac cttctccagc tactggatgc actggatcag gcagcctcct      180

ggcaagggcc tggagtggat cggcgagatc aatccttcca acggccggac caattacaat      240

gagaagctga agagcagggt gaccctgtcc gtggacaggt ccaagaacca ggcttctctg      300

aagctgtcca gcgtgaccgc cgccgatacc gccgtgtact actgtgcttc taccagcctg      360

ttctactacg ccatgaatta ctggggccag ggcaccctgg tgaccgtgag ctccgctagc      420

accaagggac cttctgtgtt ccctctggct ccttcttcta agtccacttc cggtggtaca      480

gcagctctgg gttgtctggt gaaggattac ttcccagaac cagtgactgt gtcctggaac      540

tccggagctc tgacttctgg agtgcatact ttcccagcag tgctgcaatc tagcggactg      600

tactctctgt cttccgtggt gactgtgcct tcttcttccc tggggactca aacttacatc      660

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga gccaaagagc      720

tgcgataaga cccacacctg tccaccttgt ccagctccag aactgctggg tgggccttct      780

gtgtttctgt tcccacctaa gccaaaggat accctgatga tctctaggac cccagaagtg      840

acctgtgtgg tcgtcgatgt gtctcatgaa gaccctgaag tgaagttcaa ctggtacgtg      900

gacggggtgg aagtgcataa cgcaaagacc aagcccaggg aagagcaata caactccacc      960

tacagggtgg tctccgtcct gacagtcctg catcaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaataa agccctgcct gcccctatcg agaaaaccat tagcaaagcc     1080

aaaggccagc ccagggagcc ccaggtctat acactgcccc ccagcaggga ggagatgaca     1140

aaaaatcagg tcagcctgac atgcctggtc aaaggctttt atcccagcga cattgccgtc     1200

gagtgggagt ccaatggcca gcccgagaat aattataaaa caacaccccc cgtcctggac     1260

agcgacggca gcttttttct gtatagcaaa ctgacagtcg ataaaagcag gtggcagcag     1320

ggcaatgtct tttcctgcag cgtcatgcac gaggccctgc acaatcacta tactcagaaa     1380

agcctgagcc tgtcccccgg gaaatgagcg gccgctaa                             1418


